Peptide A
Residue A
Peptide B
Residue B
Thiol Separation (Å)
HSE
Redox Score
Known Redox Activity
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Acidic amino acid decarboxylase GADL1
34
Acidic amino acid decarboxylase GADL1
34
3.9
83
0.31
E9QP13E9QP13['carboxylic acid metabolic process']['carboxylic acid metabolic process']
Insulin
93
Insulin
31
9.1
54
0.2
P01315P01315['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'glycoprotein biosynthetic process', 'insulin receptor signaling pathway', 'lactate biosynthetic process', 'lipid biosynthetic process', 'lipoprotein biosynthetic process', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of DNA replication', 'positive regulation of fatty acid biosynthetic process', 'positive regulation of glucose import', 'positive regulation of glucose metabolic process', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipoprotein lipase activity', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization to plasma membrane', 'regulation of transmembrane transporter activity', 'response to L-arginine', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'glycoprotein biosynthetic process', 'insulin receptor signaling pathway', 'lactate biosynthetic process', 'lipid biosynthetic process', 'lipoprotein biosynthetic process', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of DNA replication', 'positive regulation of fatty acid biosynthetic process', 'positive regulation of glucose import', 'positive regulation of glucose metabolic process', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipoprotein lipase activity', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization to plasma membrane', 'regulation of transmembrane transporter activity', 'response to L-arginine', 'vasodilation', 'wound healing']
Insulin
94
Insulin
31
2.0
48
1.05
P01315P01315['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'glycoprotein biosynthetic process', 'insulin receptor signaling pathway', 'lactate biosynthetic process', 'lipid biosynthetic process', 'lipoprotein biosynthetic process', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of DNA replication', 'positive regulation of fatty acid biosynthetic process', 'positive regulation of glucose import', 'positive regulation of glucose metabolic process', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipoprotein lipase activity', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization to plasma membrane', 'regulation of transmembrane transporter activity', 'response to L-arginine', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'glycoprotein biosynthetic process', 'insulin receptor signaling pathway', 'lactate biosynthetic process', 'lipid biosynthetic process', 'lipoprotein biosynthetic process', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of DNA replication', 'positive regulation of fatty acid biosynthetic process', 'positive regulation of glucose import', 'positive regulation of glucose metabolic process', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipoprotein lipase activity', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization to plasma membrane', 'regulation of transmembrane transporter activity', 'response to L-arginine', 'vasodilation', 'wound healing']
Insulin
98
Insulin
31
9.2
50
0.22
P01315P01315['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'glycoprotein biosynthetic process', 'insulin receptor signaling pathway', 'lactate biosynthetic process', 'lipid biosynthetic process', 'lipoprotein biosynthetic process', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of DNA replication', 'positive regulation of fatty acid biosynthetic process', 'positive regulation of glucose import', 'positive regulation of glucose metabolic process', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipoprotein lipase activity', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization to plasma membrane', 'regulation of transmembrane transporter activity', 'response to L-arginine', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'glycoprotein biosynthetic process', 'insulin receptor signaling pathway', 'lactate biosynthetic process', 'lipid biosynthetic process', 'lipoprotein biosynthetic process', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of DNA replication', 'positive regulation of fatty acid biosynthetic process', 'positive regulation of glucose import', 'positive regulation of glucose metabolic process', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipoprotein lipase activity', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization to plasma membrane', 'regulation of transmembrane transporter activity', 'response to L-arginine', 'vasodilation', 'wound healing']
Insulin
107
Insulin
43
2.0
54
0.9
P01315P01315['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'glycoprotein biosynthetic process', 'insulin receptor signaling pathway', 'lactate biosynthetic process', 'lipid biosynthetic process', 'lipoprotein biosynthetic process', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of DNA replication', 'positive regulation of fatty acid biosynthetic process', 'positive regulation of glucose import', 'positive regulation of glucose metabolic process', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipoprotein lipase activity', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization to plasma membrane', 'regulation of transmembrane transporter activity', 'response to L-arginine', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'glycoprotein biosynthetic process', 'insulin receptor signaling pathway', 'lactate biosynthetic process', 'lipid biosynthetic process', 'lipoprotein biosynthetic process', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of DNA replication', 'positive regulation of fatty acid biosynthetic process', 'positive regulation of glucose import', 'positive regulation of glucose metabolic process', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipoprotein lipase activity', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization to plasma membrane', 'regulation of transmembrane transporter activity', 'response to L-arginine', 'vasodilation', 'wound healing']
Prothrombin
336
Prothrombin
482
2.0
70
0.71
P00734P00734['acute-phase response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'blood coagulation', 'blood coagulation, common pathway', 'cell surface receptor signaling pathway', 'cytolysis by host of symbiont cells', 'fibrinolysis', 'negative regulation of astrocyte differentiation', 'negative regulation of blood coagulation', 'negative regulation of cytokine production involved in inflammatory response', 'negative regulation of fibrinolysis', 'negative regulation of platelet activation', 'negative regulation of proteolysis', 'neutrophil-mediated killing of gram-negative bacterium', 'platelet activation', 'positive regulation of blood coagulation', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of lipid kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to nucleus', 'positive regulation of protein phosphorylation', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of release of sequestered calcium ion into cytosol', 'proteolysis', 'regulation of blood coagulation', 'regulation of cell shape', 'regulation of cytosolic calcium ion concentration', 'response to wounding', 'zymogen activation']['acute-phase response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'blood coagulation', 'blood coagulation, common pathway', 'cell surface receptor signaling pathway', 'cytolysis by host of symbiont cells', 'fibrinolysis', 'negative regulation of astrocyte differentiation', 'negative regulation of blood coagulation', 'negative regulation of cytokine production involved in inflammatory response', 'negative regulation of fibrinolysis', 'negative regulation of platelet activation', 'negative regulation of proteolysis', 'neutrophil-mediated killing of gram-negative bacterium', 'platelet activation', 'positive regulation of blood coagulation', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of lipid kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to nucleus', 'positive regulation of protein phosphorylation', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of release of sequestered calcium ion into cytosol', 'proteolysis', 'regulation of blood coagulation', 'regulation of cell shape', 'regulation of cytosolic calcium ion concentration', 'response to wounding', 'zymogen activation']
Vascular endothelial growth factor A
52
Vascular endothelial growth factor A
77
9.6
71
0.15
P15692P15692['activation of protein kinase activity', 'angiogenesis', 'artery morphogenesis', 'basophil chemotaxis', 'branching involved in blood vessel morphogenesis', 'camera-type eye morphogenesis', 'cardiac muscle cell development', 'cardiac vascular smooth muscle cell development', 'cell maturation', 'cell migration involved in sprouting angiogenesis', 'cellular response to hypoxia', 'cellular response to vascular endothelial growth factor stimulus', 'cellular stress response to acid chemical', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'coronary vein morphogenesis', 'dopaminergic neuron differentiation', 'endothelial cell chemotaxis', 'epithelial cell differentiation', 'eye photoreceptor cell development', 'heart morphogenesis', 'in utero embryonic development', 'induction of positive chemotaxis', 'kidney development', 'lactation', 'lung development', 'lymph vessel morphogenesis', 'macrophage differentiation', 'mammary gland alveolus development', 'mesoderm development', 'monocyte differentiation', 'motor neuron migration', 'negative regulation of adherens junction organization', 'negative regulation of apoptotic process', 'negative regulation of blood-brain barrier permeability', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of establishment of endothelial barrier', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'outflow tract morphogenesis', 'ovarian follicle development', 'positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell migration by vascular endothelial growth factor signaling pathway', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway', 'positive regulation of cold-induced thermogenesis', 'positive regulation of CREB transcription factor activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of histone deacetylase activity', 'positive regulation of leukocyte migration', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of neuroblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of positive chemotaxis', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C signaling', 'positive regulation of protein kinase D signaling', 'positive regulation of protein localization to early endosome', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor internalization', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of trophoblast cell migration', 'positive regulation of vascular permeability', 'post-embryonic camera-type eye development', 'primitive erythrocyte differentiation', 'regulation of cell shape', 'regulation of nitric oxide mediated signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of transcription by RNA polymerase II', 'response to hypoxia', 'sprouting angiogenesis', 'surfactant homeostasis', 'tube formation', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway']['activation of protein kinase activity', 'angiogenesis', 'artery morphogenesis', 'basophil chemotaxis', 'branching involved in blood vessel morphogenesis', 'camera-type eye morphogenesis', 'cardiac muscle cell development', 'cardiac vascular smooth muscle cell development', 'cell maturation', 'cell migration involved in sprouting angiogenesis', 'cellular response to hypoxia', 'cellular response to vascular endothelial growth factor stimulus', 'cellular stress response to acid chemical', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'coronary vein morphogenesis', 'dopaminergic neuron differentiation', 'endothelial cell chemotaxis', 'epithelial cell differentiation', 'eye photoreceptor cell development', 'heart morphogenesis', 'in utero embryonic development', 'induction of positive chemotaxis', 'kidney development', 'lactation', 'lung development', 'lymph vessel morphogenesis', 'macrophage differentiation', 'mammary gland alveolus development', 'mesoderm development', 'monocyte differentiation', 'motor neuron migration', 'negative regulation of adherens junction organization', 'negative regulation of apoptotic process', 'negative regulation of blood-brain barrier permeability', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of establishment of endothelial barrier', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'outflow tract morphogenesis', 'ovarian follicle development', 'positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell migration by vascular endothelial growth factor signaling pathway', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway', 'positive regulation of cold-induced thermogenesis', 'positive regulation of CREB transcription factor activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of histone deacetylase activity', 'positive regulation of leukocyte migration', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of neuroblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of positive chemotaxis', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C signaling', 'positive regulation of protein kinase D signaling', 'positive regulation of protein localization to early endosome', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor internalization', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of trophoblast cell migration', 'positive regulation of vascular permeability', 'post-embryonic camera-type eye development', 'primitive erythrocyte differentiation', 'regulation of cell shape', 'regulation of nitric oxide mediated signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of transcription by RNA polymerase II', 'response to hypoxia', 'sprouting angiogenesis', 'surfactant homeostasis', 'tube formation', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway']
Mothers against decapentaplegic homolog 7
278
Mothers against decapentaplegic homolog 7
262
9.6
83
0.13
O35253O35253['adherens junction assembly', 'anatomical structure morphogenesis', 'artery morphogenesis', 'BMP signaling pathway', 'cell differentiation', 'cellular response to leukemia inhibitory factor', 'cellular response to transforming growth factor beta stimulus', 'intracellular signal transduction', 'negative regulation of BMP signaling pathway', 'negative regulation of chondrocyte proliferation', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of ossification', 'negative regulation of pathway-restricted SMAD protein phosphorylation', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of peptidyl-threonine phosphorylation', 'negative regulation of protein ubiquitination', 'negative regulation of T cell cytokine production', 'negative regulation of T-helper 17 cell differentiation', 'negative regulation of T-helper 17 type immune response', 'negative regulation of transcription by competitive promoter binding', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of ubiquitin-protein transferase activity', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of cell-cell adhesion', 'positive regulation of chondrocyte hypertrophy', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of protein ubiquitination', 'protein stabilization', 'protein-containing complex localization', 'regulation of activin receptor signaling pathway', 'regulation of cardiac muscle contraction', 'regulation of epithelial to mesenchymal transition', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulation of ventricular cardiac muscle cell membrane depolarization', 'response to laminar fluid shear stress', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'ureteric bud development', 'ventricular cardiac muscle tissue morphogenesis', 'ventricular septum morphogenesis']['adherens junction assembly', 'anatomical structure morphogenesis', 'artery morphogenesis', 'BMP signaling pathway', 'cell differentiation', 'cellular response to leukemia inhibitory factor', 'cellular response to transforming growth factor beta stimulus', 'intracellular signal transduction', 'negative regulation of BMP signaling pathway', 'negative regulation of chondrocyte proliferation', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of ossification', 'negative regulation of pathway-restricted SMAD protein phosphorylation', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of peptidyl-threonine phosphorylation', 'negative regulation of protein ubiquitination', 'negative regulation of T cell cytokine production', 'negative regulation of T-helper 17 cell differentiation', 'negative regulation of T-helper 17 type immune response', 'negative regulation of transcription by competitive promoter binding', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of ubiquitin-protein transferase activity', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of cell-cell adhesion', 'positive regulation of chondrocyte hypertrophy', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of protein ubiquitination', 'protein stabilization', 'protein-containing complex localization', 'regulation of activin receptor signaling pathway', 'regulation of cardiac muscle contraction', 'regulation of epithelial to mesenchymal transition', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulation of ventricular cardiac muscle cell membrane depolarization', 'response to laminar fluid shear stress', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'ureteric bud development', 'ventricular cardiac muscle tissue morphogenesis', 'ventricular septum morphogenesis']
Proprotein convertase subtilisin/kexin type 9
378
Low-density lipoprotein receptor
325
9.5
74
0.14
Q8NBP7P01130['apoptotic process', 'cellular response to insulin stimulus', 'cellular response to starvation', 'cholesterol homeostasis', 'cholesterol metabolic process', 'kidney development', 'lipoprotein metabolic process', 'liver development', 'low-density lipoprotein particle receptor catabolic process', 'lysosomal transport', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of low-density lipoprotein particle receptor binding', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of receptor internalization', 'negative regulation of receptor recycling', 'negative regulation of receptor-mediated endocytosis involved in cholesterol transport', 'negative regulation of sodium ion transmembrane transporter activity', 'neurogenesis', 'neuron differentiation', 'phospholipid metabolic process', 'positive regulation of low-density lipoprotein particle receptor catabolic process', 'positive regulation of neuron apoptotic process', 'positive regulation of receptor internalization', 'protein autoprocessing', 'regulation of neuron apoptotic process', 'regulation of signaling receptor activity', 'triglyceride metabolic process']['amyloid-beta clearance', 'amyloid-beta clearance by cellular catabolic process', 'artery morphogenesis', 'cellular response to fatty acid', 'cellular response to low-density lipoprotein particle stimulus', 'cholesterol homeostasis', 'cholesterol import', 'cholesterol metabolic process', 'cholesterol transport', 'endocytosis', 'high-density lipoprotein particle clearance', 'intestinal cholesterol absorption', 'lipid metabolic process', 'lipoprotein catabolic process', 'long-term memory', 'low-density lipoprotein particle clearance', 'negative regulation of amyloid fibril formation', 'negative regulation of astrocyte activation', 'negative regulation of gene expression', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of microglial cell activation', 'negative regulation of protein metabolic process', 'negative regulation of receptor recycling', 'phagocytosis', 'phospholipid transport', 'plasma lipoprotein particle clearance', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of lysosomal protein catabolic process', 'positive regulation of triglyceride biosynthetic process', 'receptor-mediated endocytosis', 'receptor-mediated endocytosis involved in cholesterol transport', 'regulation of cholesterol metabolic process', 'regulation of phosphatidylcholine catabolic process', 'regulation of protein metabolic process', 'response to caloric restriction']
3-hydroxy-3-methylglutaryl-coenzyme A reductase
600
3-hydroxy-3-methylglutaryl-coenzyme A reductase
708
9.6
80
0.13
P04035P04035['cholesterol biosynthetic process', 'coenzyme A metabolic process', 'isoprenoid biosynthetic process', 'negative regulation of amyloid-beta clearance', 'negative regulation of MAP kinase activity', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'sterol biosynthetic process', 'visual learning']['cholesterol biosynthetic process', 'coenzyme A metabolic process', 'isoprenoid biosynthetic process', 'negative regulation of amyloid-beta clearance', 'negative regulation of MAP kinase activity', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'sterol biosynthetic process', 'visual learning']
3-hydroxybutyrate dehydrogenase type 2
172
3-hydroxybutyrate dehydrogenase type 2
145
9.6
96
0.11
Q9BUT1Q9BUT1['epithelial cell differentiation', 'fatty acid beta-oxidation', 'heme metabolic process', 'iron ion homeostasis', 'siderophore biosynthetic process']['epithelial cell differentiation', 'fatty acid beta-oxidation', 'heme metabolic process', 'iron ion homeostasis', 'siderophore biosynthetic process']
Thialysine N-epsilon-acetyltransferase
158
Thialysine N-epsilon-acetyltransferase
122
9.6
65
0.16
Q96F10Q96F10['nor-spermidine metabolic process', 'putrescine acetylation', 'spermidine acetylation', 'spermine acetylation']['nor-spermidine metabolic process', 'putrescine acetylation', 'spermidine acetylation', 'spermine acetylation']
Hypoxanthine-guanine phosphoribosyltransferase
66
Hypoxanthine-guanine phosphoribosyltransferase
66
9.6
72
0.15
P00492P00492['adenine metabolic process', 'AMP salvage', 'central nervous system neuron development', 'cerebral cortex neuron differentiation', 'dendrite morphogenesis', 'dopamine metabolic process', 'dopaminergic neuron differentiation', 'GMP catabolic process', 'GMP salvage', 'grooming behavior', 'guanine salvage', 'hypoxanthine metabolic process', 'hypoxanthine salvage', 'IMP metabolic process', 'IMP salvage', 'locomotory behavior', 'lymphocyte proliferation', 'positive regulation of dopamine metabolic process', 'protein homotetramerization', 'purine nucleotide biosynthetic process', 'purine ribonucleoside salvage', 'response to amphetamine', 'striatum development', 'T cell mediated cytotoxicity']['adenine metabolic process', 'AMP salvage', 'central nervous system neuron development', 'cerebral cortex neuron differentiation', 'dendrite morphogenesis', 'dopamine metabolic process', 'dopaminergic neuron differentiation', 'GMP catabolic process', 'GMP salvage', 'grooming behavior', 'guanine salvage', 'hypoxanthine metabolic process', 'hypoxanthine salvage', 'IMP metabolic process', 'IMP salvage', 'locomotory behavior', 'lymphocyte proliferation', 'positive regulation of dopamine metabolic process', 'protein homotetramerization', 'purine nucleotide biosynthetic process', 'purine ribonucleoside salvage', 'response to amphetamine', 'striatum development', 'T cell mediated cytotoxicity']
Interleukin-12 subunit beta
199
Interleukin-23 subunit alpha
77
9.6
67
0.16
P29460Q9NPF7['cell migration', 'cellular response to interferon-gamma', 'cellular response to lipopolysaccharide', 'cytokine-mediated signaling pathway', 'defense response to Gram-negative bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'natural killer cell activation', 'natural killer cell activation involved in immune response', 'negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'negative regulation of inflammatory response to antigenic stimulus', 'negative regulation of interleukin-10 production', 'negative regulation of interleukin-17 production', 'negative regulation of protein secretion', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of vascular endothelial growth factor signaling pathway', 'positive regulation of activated T cell proliferation', 'positive regulation of activation of Janus kinase activity', 'positive regulation of cell adhesion', 'positive regulation of defense response to virus by host', 'positive regulation of granulocyte macrophage colony-stimulating factor production', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-10 production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-17 production', 'positive regulation of lymphocyte proliferation', 'positive regulation of memory T cell differentiation', 'positive regulation of mononuclear cell proliferation', 'positive regulation of natural killer cell activation', 'positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target', 'positive regulation of natural killer cell proliferation', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of NK T cell activation', 'positive regulation of NK T cell proliferation', 'positive regulation of osteoclast differentiation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell apoptotic process', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of T cell proliferation', 'positive regulation of T-helper 1 type immune response', 'positive regulation of T-helper 17 cell lineage commitment', 'positive regulation of T-helper 17 type immune response', 'positive regulation of tissue remodeling', 'positive regulation of tumor necrosis factor production', 'positive regulation of tyrosine phosphorylation of STAT protein', 'regulation of cytokine production', 'regulation of tyrosine phosphorylation of STAT protein', 'response to UV-B', 'sensory perception of pain', 'sexual reproduction', 'T cell proliferation', 'T-helper 1 type immune response', 'T-helper cell differentiation']['defense response to Gram-negative bacterium', 'defense response to virus', 'immune response', 'inflammatory response', 'innate immune response', 'negative regulation of interleukin-10 production', 'positive regulation of activated T cell proliferation', 'positive regulation of activation of Janus kinase activity', 'positive regulation of defense response to virus by host', 'positive regulation of granulocyte macrophage colony-stimulating factor production', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-10 production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-17 production', 'positive regulation of memory T cell differentiation', 'positive regulation of natural killer cell activation', 'positive regulation of natural killer cell proliferation', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of NK T cell activation', 'positive regulation of NK T cell proliferation', 'positive regulation of osteoclast differentiation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of T cell proliferation', 'positive regulation of T-helper 1 type immune response', 'positive regulation of T-helper 17 cell lineage commitment', 'positive regulation of T-helper 17 type immune response', 'positive regulation of tissue remodeling', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'positive regulation of tyrosine phosphorylation of STAT protein', 'regulation of tyrosine phosphorylation of STAT protein', 'T cell proliferation', 'tissue remodeling']
C-C motif chemokine 5
34
C-C motif chemokine 5
33
9.6
79
0.13
P13501P13501['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'chemokine-mediated signaling pathway', 'chemotaxis', 'dendritic cell chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of innate immune response', 'positive regulation of macrophage chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of translational initiation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of viral genome replication', 'protein kinase B signaling', 'regulation of chronic inflammatory response', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to toxic substance', 'response to virus']['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'chemokine-mediated signaling pathway', 'chemotaxis', 'dendritic cell chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of innate immune response', 'positive regulation of macrophage chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of translational initiation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of viral genome replication', 'protein kinase B signaling', 'regulation of chronic inflammatory response', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to toxic substance', 'response to virus']
Fibrinogen beta chain
227
Fibrinogen gamma chain
161
9.6
69
0.15
P02675P02679['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Norrin
69
Norrin
95
9.6
81
0.13
Q00604Q00604['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']
C-C motif chemokine 17
57
C-C motif chemokine 17
73
9.6
64
0.16
Q92583Q92583['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation of myoblast differentiation', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation of myoblast differentiation', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']
Complement C4-A
876
Complement C4-A
1588
9.6
71
0.15
P0C0L4P0C0L4['complement activation', 'complement activation, classical pathway', 'inflammatory response', 'innate immune response', 'positive regulation of apoptotic cell clearance', 'positive regulation of immune response', 'positive regulation of opsonization']['complement activation', 'complement activation, classical pathway', 'inflammatory response', 'innate immune response', 'positive regulation of apoptotic cell clearance', 'positive regulation of immune response', 'positive regulation of opsonization']
Inhibin beta A chain
390
Inhibin beta A chain
391
9.6
70
0.15
P08476P08476['activin receptor signaling pathway', 'cell differentiation', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular response to cholesterol', 'cellular response to follicle-stimulating hormone stimulus', 'defense response', 'endodermal cell differentiation', 'erythrocyte differentiation', 'extrinsic apoptotic signaling pathway', 'eyelid development in camera-type eye', 'GABAergic neuron differentiation', 'hair follicle development', 'hematopoietic progenitor cell differentiation', 'hemoglobin biosynthetic process', 'male gonad development', 'mesodermal cell differentiation', 'multicellular organism aging', 'negative regulation of B cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of follicle-stimulating hormone secretion', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of interferon-gamma production', 'negative regulation of macrophage differentiation', 'negative regulation of phosphorylation', 'nervous system development', 'odontogenesis', 'ovarian follicle development', 'positive regulation of erythrocyte differentiation', 'positive regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'positive regulation of follicle-stimulating hormone secretion', 'positive regulation of gene expression', 'positive regulation of ovulation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein metabolic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'progesterone secretion', 'regulation of follicle-stimulating hormone secretion', 'regulation of transcription by RNA polymerase II', 'response to xenobiotic stimulus', 'roof of mouth development', 'SMAD protein signal transduction', 'striatal medium spiny neuron differentiation', 'transcription by RNA polymerase II']['activin receptor signaling pathway', 'cell differentiation', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular response to cholesterol', 'cellular response to follicle-stimulating hormone stimulus', 'defense response', 'endodermal cell differentiation', 'erythrocyte differentiation', 'extrinsic apoptotic signaling pathway', 'eyelid development in camera-type eye', 'GABAergic neuron differentiation', 'hair follicle development', 'hematopoietic progenitor cell differentiation', 'hemoglobin biosynthetic process', 'male gonad development', 'mesodermal cell differentiation', 'multicellular organism aging', 'negative regulation of B cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of follicle-stimulating hormone secretion', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of interferon-gamma production', 'negative regulation of macrophage differentiation', 'negative regulation of phosphorylation', 'nervous system development', 'odontogenesis', 'ovarian follicle development', 'positive regulation of erythrocyte differentiation', 'positive regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'positive regulation of follicle-stimulating hormone secretion', 'positive regulation of gene expression', 'positive regulation of ovulation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein metabolic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'progesterone secretion', 'regulation of follicle-stimulating hormone secretion', 'regulation of transcription by RNA polymerase II', 'response to xenobiotic stimulus', 'roof of mouth development', 'SMAD protein signal transduction', 'striatal medium spiny neuron differentiation', 'transcription by RNA polymerase II']
Transforming growth factor beta-1 proprotein
355
Transforming growth factor beta-1 proprotein
356
9.6
85
0.12
P01137P01137['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']
Retinoblastoma-like protein 1
846
EP300-interacting inhibitor of differentiation 1
180
9.6
73
0.14
P28749Q9Y6B2['cell cycle', 'cell differentiation', 'chromatin organization', 'negative regulation of cellular senescence', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'regulation of cell division', 'regulation of lipid kinase activity']['cell cycle', 'cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'regulation of cell differentiation']
All-trans-retinol dehydrogenase [NAD(+)] ADH1B
101
All-trans-retinol dehydrogenase [NAD(+)] ADH1B
287
9.6
66
0.16
P00325P00325['ethanol oxidation', 'retinoic acid metabolic process', 'retinoid metabolic process', 'retinol metabolic process']['ethanol oxidation', 'retinoic acid metabolic process', 'retinoid metabolic process', 'retinol metabolic process']
Ectodysplasin-A
346
Ectodysplasin-A
332
9.6
93
0.11
Q92838Q92838['animal organ development', 'canonical Wnt signaling pathway', 'cell differentiation', 'cell-matrix adhesion', 'cytokine-mediated signaling pathway', 'gene expression', 'hair follicle placode formation', 'immune response', 'odontogenesis of dentin-containing tooth', 'pigmentation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of gene expression', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'regulation of NIK/NF-kappaB signaling', 'salivary gland cavitation', 'trachea gland development']['animal organ development', 'canonical Wnt signaling pathway', 'cell differentiation', 'cell-matrix adhesion', 'cytokine-mediated signaling pathway', 'gene expression', 'hair follicle placode formation', 'immune response', 'odontogenesis of dentin-containing tooth', 'pigmentation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of gene expression', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'regulation of NIK/NF-kappaB signaling', 'salivary gland cavitation', 'trachea gland development']
Vitamin K-dependent protein C
319
Vitamin K-dependent protein C
175
9.6
75
0.14
P04070P04070['blood coagulation', 'negative regulation of apoptotic process', 'negative regulation of blood coagulation', 'negative regulation of coagulation', 'negative regulation of inflammatory response', 'positive regulation of establishment of endothelial barrier', 'proteolysis']['blood coagulation', 'negative regulation of apoptotic process', 'negative regulation of blood coagulation', 'negative regulation of coagulation', 'negative regulation of inflammatory response', 'positive regulation of establishment of endothelial barrier', 'proteolysis']
Protein S100-A4
81
Protein S100-A4
76
9.6
56
0.19
P26447P26447['epithelial to mesenchymal transition', 'positive regulation of I-kappaB kinase/NF-kappaB signaling']['epithelial to mesenchymal transition', 'positive regulation of I-kappaB kinase/NF-kappaB signaling']
Glucocorticoid receptor
457
Glucocorticoid receptor
457
9.6
73
0.14
P04150P04150['adrenal gland development', 'apoptotic process', 'cell cycle', 'cell division', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin organization', 'chromosome segregation', 'glucocorticoid metabolic process', 'intracellular steroid hormone receptor signaling pathway', 'mammary gland duct morphogenesis', 'maternal behavior', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'signal transduction']['adrenal gland development', 'apoptotic process', 'cell cycle', 'cell division', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin organization', 'chromosome segregation', 'glucocorticoid metabolic process', 'intracellular steroid hormone receptor signaling pathway', 'mammary gland duct morphogenesis', 'maternal behavior', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'signal transduction']
Fibrinogen beta chain
316
Fibrinogen gamma chain
165
9.6
70
0.15
P02675P02679['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Insulin
100
Insulin
31
9.6
53
0.2
P01308P01308['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']
Insulin
95
Insulin
31
9.6
52
0.2
P01317P01317['estradiol secretion', 'feeding behavior', 'glucose import in response to insulin stimulus', 'glucose metabolic process', 'negative regulation of apoptotic process', 'negative regulation of appetite', 'negative regulation of lactation', 'negative regulation of lipid catabolic process', 'positive regulation of blood circulation', 'positive regulation of cell maturation', 'positive regulation of gene expression', 'positive regulation of insulin secretion', 'positive regulation of lactation', 'positive regulation of mammary gland epithelial cell proliferation', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Rho protein signal transduction', 'protein secretion', 'response to butyrate', 'response to food', 'response to glucose', 'response to growth hormone', 'response to heat', 'response to L-arginine', 'response to nutrient levels']['estradiol secretion', 'feeding behavior', 'glucose import in response to insulin stimulus', 'glucose metabolic process', 'negative regulation of apoptotic process', 'negative regulation of appetite', 'negative regulation of lactation', 'negative regulation of lipid catabolic process', 'positive regulation of blood circulation', 'positive regulation of cell maturation', 'positive regulation of gene expression', 'positive regulation of insulin secretion', 'positive regulation of lactation', 'positive regulation of mammary gland epithelial cell proliferation', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Rho protein signal transduction', 'protein secretion', 'response to butyrate', 'response to food', 'response to glucose', 'response to growth hormone', 'response to heat', 'response to L-arginine', 'response to nutrient levels']
Ribonuclease inhibitor
409
Non-secretory ribonuclease
98
9.6
77
0.14
P13489P10153['mRNA catabolic process', 'regulation of angiogenesis']['chemotaxis', 'defense response to virus', 'innate immune response in mucosa', 'RNA catabolic process', 'RNA phosphodiester bond hydrolysis']
Caspase-3
47
Caspase-3
220
9.6
72
0.15
P42574P42574['anterior neural tube closure', 'apoptotic process', 'apoptotic signaling pathway', 'axonal fasciculation', 'B cell homeostasis', 'cell fate commitment', 'cellular response to DNA damage stimulus', 'cellular response to staurosporine', 'epithelial cell apoptotic process', 'erythrocyte differentiation', 'execution phase of apoptosis', 'fibroblast apoptotic process', 'glial cell apoptotic process', 'heart development', 'hippocampus development', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway in response to osmotic stress', 'keratinocyte differentiation', 'learning or memory', 'leukocyte apoptotic process', 'luteolysis', 'negative regulation of activated T cell proliferation', 'negative regulation of apoptotic process', 'negative regulation of B cell proliferation', 'neuron apoptotic process', 'neuron differentiation', 'neurotrophin TRK receptor signaling pathway', 'platelet formation', 'positive regulation of amyloid-beta formation', 'positive regulation of apoptotic DNA fragmentation', 'positive regulation of apoptotic process', 'positive regulation of neuron apoptotic process', 'protein catabolic process', 'protein processing', 'proteolysis', 'regulation of macroautophagy', 'regulation of protein stability', 'response to amino acid', 'response to antibiotic', 'response to cobalt ion', 'response to estradiol', 'response to glucocorticoid', 'response to glucose', 'response to hydrogen peroxide', 'response to hypoxia', 'response to lipopolysaccharide', 'response to nicotine', 'response to tumor necrosis factor', 'response to UV', 'response to X-ray', 'response to xenobiotic stimulus', 'sensory perception of sound', 'striated muscle cell differentiation', 'T cell homeostasis', 'wound healing']['anterior neural tube closure', 'apoptotic process', 'apoptotic signaling pathway', 'axonal fasciculation', 'B cell homeostasis', 'cell fate commitment', 'cellular response to DNA damage stimulus', 'cellular response to staurosporine', 'epithelial cell apoptotic process', 'erythrocyte differentiation', 'execution phase of apoptosis', 'fibroblast apoptotic process', 'glial cell apoptotic process', 'heart development', 'hippocampus development', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway in response to osmotic stress', 'keratinocyte differentiation', 'learning or memory', 'leukocyte apoptotic process', 'luteolysis', 'negative regulation of activated T cell proliferation', 'negative regulation of apoptotic process', 'negative regulation of B cell proliferation', 'neuron apoptotic process', 'neuron differentiation', 'neurotrophin TRK receptor signaling pathway', 'platelet formation', 'positive regulation of amyloid-beta formation', 'positive regulation of apoptotic DNA fragmentation', 'positive regulation of apoptotic process', 'positive regulation of neuron apoptotic process', 'protein catabolic process', 'protein processing', 'proteolysis', 'regulation of macroautophagy', 'regulation of protein stability', 'response to amino acid', 'response to antibiotic', 'response to cobalt ion', 'response to estradiol', 'response to glucocorticoid', 'response to glucose', 'response to hydrogen peroxide', 'response to hypoxia', 'response to lipopolysaccharide', 'response to nicotine', 'response to tumor necrosis factor', 'response to UV', 'response to X-ray', 'response to xenobiotic stimulus', 'sensory perception of sound', 'striated muscle cell differentiation', 'T cell homeostasis', 'wound healing']
Cellular tumor antigen p53
176
Cellular tumor antigen p53
176
9.6
69
0.15
P04637P04637['autophagy', 'B cell lineage commitment', 'bone marrow development', 'cardiac muscle cell apoptotic process', 'cardiac septum morphogenesis', 'cellular response to actinomycin D', 'cellular response to DNA damage stimulus', 'cellular response to gamma radiation', 'cellular response to glucose starvation', 'cellular response to hypoxia', 'cellular response to ionizing radiation', 'cellular response to UV', 'cellular response to UV-C', 'cellular response to xenobiotic stimulus', 'cellular senescence', 'cerebellum development', 'chromatin assembly', 'circadian behavior', 'determination of adult lifespan', 'DNA damage response, signal transduction by p53 class mediator', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator', 'double-strand break repair', 'embryonic organ development', 'entrainment of circadian clock by photoperiod', 'ER overload response', 'fibroblast proliferation', 'gastrulation', 'glial cell proliferation', 'glucose catabolic process to lactate via pyruvate', 'hematopoietic progenitor cell differentiation', 'hematopoietic stem cell differentiation', 'in utero embryonic development', 'interferon-gamma-mediated signaling pathway', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'intrinsic apoptotic signaling pathway in response to hypoxia', 'mitochondrial DNA repair', 'mitophagy', 'mitotic G1 DNA damage checkpoint signaling', 'mRNA transcription', 'multicellular organism growth', 'necroptotic process', 'negative regulation of apoptotic process', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of DNA replication', 'negative regulation of fibroblast proliferation', 'negative regulation of G1 to G0 transition', 'negative regulation of glial cell proliferation', 'negative regulation of glucose catabolic process to lactate via pyruvate', 'negative regulation of helicase activity', 'negative regulation of miRNA maturation', 'negative regulation of mitophagy', 'negative regulation of neuroblast proliferation', 'negative regulation of pentose-phosphate shunt', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of stem cell proliferation', 'negative regulation of telomerase activity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'neuroblast proliferation', 'neuron apoptotic process', 'nucleotide-excision repair', 'oligodendrocyte apoptotic process', 'oxidative stress-induced premature senescence', 'positive regulation of apoptotic process', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of cellular senescence', 'positive regulation of execution phase of apoptosis', 'positive regulation of gene expression', 'positive regulation of histone deacetylation', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of mitochondrial membrane permeability', 'positive regulation of neuron apoptotic process', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of programmed necrotic cell death', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of release of cytochrome c from mitochondria', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of thymocyte apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription from RNA polymerase II promoter in response to stress', 'positive regulation of transcription, DNA-templated', 'protein import into nucleus', 'protein localization', 'protein stabilization', 'protein tetramerization', 'protein-containing complex assembly', 'Ras protein signal transduction', 'reactive oxygen species metabolic process', 'regulation of apoptotic process', 'regulation of cell cycle', 'regulation of cell cycle G2/M phase transition', 'regulation of DNA damage response, signal transduction by p53 class mediator', 'regulation of fibroblast apoptotic process', 'regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'regulation of mitochondrial membrane permeability involved in apoptotic process', 'regulation of tissue remodeling', 'regulation of transcription by RNA polymerase II', 'regulation of transcription from RNA polymerase II promoter in response to DNA damage', 'regulation of transcription, DNA-templated', 'release of cytochrome c from mitochondria', 'replicative senescence', 'response to antibiotic', 'response to gamma radiation', 'response to ischemia', 'response to salt stress', 'response to X-ray', 'rRNA transcription', 'signal transduction by p53 class mediator', 'somitogenesis', 'stem cell proliferation', 'T cell differentiation in thymus', 'T cell lineage commitment', 'T cell proliferation involved in immune response', 'thymocyte apoptotic process', 'transforming growth factor beta receptor signaling pathway', 'tumor necrosis factor-mediated signaling pathway', 'viral process']['autophagy', 'B cell lineage commitment', 'bone marrow development', 'cardiac muscle cell apoptotic process', 'cardiac septum morphogenesis', 'cellular response to actinomycin D', 'cellular response to DNA damage stimulus', 'cellular response to gamma radiation', 'cellular response to glucose starvation', 'cellular response to hypoxia', 'cellular response to ionizing radiation', 'cellular response to UV', 'cellular response to UV-C', 'cellular response to xenobiotic stimulus', 'cellular senescence', 'cerebellum development', 'chromatin assembly', 'circadian behavior', 'determination of adult lifespan', 'DNA damage response, signal transduction by p53 class mediator', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator', 'double-strand break repair', 'embryonic organ development', 'entrainment of circadian clock by photoperiod', 'ER overload response', 'fibroblast proliferation', 'gastrulation', 'glial cell proliferation', 'glucose catabolic process to lactate via pyruvate', 'hematopoietic progenitor cell differentiation', 'hematopoietic stem cell differentiation', 'in utero embryonic development', 'interferon-gamma-mediated signaling pathway', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'intrinsic apoptotic signaling pathway in response to hypoxia', 'mitochondrial DNA repair', 'mitophagy', 'mitotic G1 DNA damage checkpoint signaling', 'mRNA transcription', 'multicellular organism growth', 'necroptotic process', 'negative regulation of apoptotic process', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of DNA replication', 'negative regulation of fibroblast proliferation', 'negative regulation of G1 to G0 transition', 'negative regulation of glial cell proliferation', 'negative regulation of glucose catabolic process to lactate via pyruvate', 'negative regulation of helicase activity', 'negative regulation of miRNA maturation', 'negative regulation of mitophagy', 'negative regulation of neuroblast proliferation', 'negative regulation of pentose-phosphate shunt', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of stem cell proliferation', 'negative regulation of telomerase activity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'neuroblast proliferation', 'neuron apoptotic process', 'nucleotide-excision repair', 'oligodendrocyte apoptotic process', 'oxidative stress-induced premature senescence', 'positive regulation of apoptotic process', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of cellular senescence', 'positive regulation of execution phase of apoptosis', 'positive regulation of gene expression', 'positive regulation of histone deacetylation', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of mitochondrial membrane permeability', 'positive regulation of neuron apoptotic process', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of programmed necrotic cell death', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of release of cytochrome c from mitochondria', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of thymocyte apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription from RNA polymerase II promoter in response to stress', 'positive regulation of transcription, DNA-templated', 'protein import into nucleus', 'protein localization', 'protein stabilization', 'protein tetramerization', 'protein-containing complex assembly', 'Ras protein signal transduction', 'reactive oxygen species metabolic process', 'regulation of apoptotic process', 'regulation of cell cycle', 'regulation of cell cycle G2/M phase transition', 'regulation of DNA damage response, signal transduction by p53 class mediator', 'regulation of fibroblast apoptotic process', 'regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'regulation of mitochondrial membrane permeability involved in apoptotic process', 'regulation of tissue remodeling', 'regulation of transcription by RNA polymerase II', 'regulation of transcription from RNA polymerase II promoter in response to DNA damage', 'regulation of transcription, DNA-templated', 'release of cytochrome c from mitochondria', 'replicative senescence', 'response to antibiotic', 'response to gamma radiation', 'response to ischemia', 'response to salt stress', 'response to X-ray', 'rRNA transcription', 'signal transduction by p53 class mediator', 'somitogenesis', 'stem cell proliferation', 'T cell differentiation in thymus', 'T cell lineage commitment', 'T cell proliferation involved in immune response', 'thymocyte apoptotic process', 'transforming growth factor beta receptor signaling pathway', 'tumor necrosis factor-mediated signaling pathway', 'viral process']
Coagulation factor IX
335
Coagulation factor IX
170
9.6
75
0.14
P00740P00740['blood coagulation', 'blood coagulation, intrinsic pathway', 'proteolysis', 'zymogen activation']['blood coagulation', 'blood coagulation, intrinsic pathway', 'proteolysis', 'zymogen activation']
Beta-nerve growth factor
231
Beta-nerve growth factor
189
9.5
91
0.12
P01139P01139['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'adult locomotory behavior', 'axon extension', 'circadian rhythm', 'extrinsic apoptotic signaling pathway in absence of ligand', 'extrinsic apoptotic signaling pathway via death domain receptors', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of type B pancreatic cell apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron projection development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of axon extension', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of collateral sprouting', 'positive regulation of DNA binding', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of neuron differentiation', 'positive regulation of neuron maturation', 'positive regulation of neuron projection development', 'positive regulation of neurotrophin TRK receptor signaling pathway', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein autophosphorylation', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of protein ubiquitination', 'positive regulation of Ras protein signal transduction', 'positive regulation of stem cell proliferation', 'protein phosphorylation', 'regulation of neuron differentiation', 'regulation of neurotransmitter secretion', 'regulation of release of sequestered calcium ion into cytosol', 'sensory perception of pain', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'adult locomotory behavior', 'axon extension', 'circadian rhythm', 'extrinsic apoptotic signaling pathway in absence of ligand', 'extrinsic apoptotic signaling pathway via death domain receptors', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of type B pancreatic cell apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron projection development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of axon extension', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of collateral sprouting', 'positive regulation of DNA binding', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of neuron differentiation', 'positive regulation of neuron maturation', 'positive regulation of neuron projection development', 'positive regulation of neurotrophin TRK receptor signaling pathway', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein autophosphorylation', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of protein ubiquitination', 'positive regulation of Ras protein signal transduction', 'positive regulation of stem cell proliferation', 'protein phosphorylation', 'regulation of neuron differentiation', 'regulation of neurotransmitter secretion', 'regulation of release of sequestered calcium ion into cytosol', 'sensory perception of pain', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Protein S100-A4
76
Protein S100-A4
86
9.6
74
0.14
P26447P26447['epithelial to mesenchymal transition', 'positive regulation of I-kappaB kinase/NF-kappaB signaling']['epithelial to mesenchymal transition', 'positive regulation of I-kappaB kinase/NF-kappaB signaling']
Glucocorticoid receptor
482
Glucocorticoid receptor
495
9.6
68
0.15
P06536P06536['adrenal gland development', 'aging', 'androgen metabolic process', 'brain development', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to magnesium ion', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin remodeling', 'circadian rhythm', 'epigenetic maintenance of chromatin in transcription-competent conformation', 'female pregnancy', 'glucocorticoid metabolic process', 'glucocorticoid receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lung development', 'mammary gland duct morphogenesis', 'maternal behavior', 'muscle atrophy', 'negative regulation of apoptotic process', 'negative regulation of synaptic plasticity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular permeability', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of dendritic spine development', 'positive regulation of glucocorticoid receptor signaling pathway', 'positive regulation of glutamate secretion', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'protein-containing complex assembly', 'regulation of cell population proliferation', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of glucose metabolic process', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to activity', 'response to arsenic-containing substance', 'response to calcium ion', 'response to corticosterone', 'response to dexamethasone', 'response to electrical stimulus', 'response to inactivity', 'response to insulin', 'response to mercury ion', 'response to radiation']['adrenal gland development', 'aging', 'androgen metabolic process', 'brain development', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to magnesium ion', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin remodeling', 'circadian rhythm', 'epigenetic maintenance of chromatin in transcription-competent conformation', 'female pregnancy', 'glucocorticoid metabolic process', 'glucocorticoid receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lung development', 'mammary gland duct morphogenesis', 'maternal behavior', 'muscle atrophy', 'negative regulation of apoptotic process', 'negative regulation of synaptic plasticity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular permeability', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of dendritic spine development', 'positive regulation of glucocorticoid receptor signaling pathway', 'positive regulation of glutamate secretion', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'protein-containing complex assembly', 'regulation of cell population proliferation', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of glucose metabolic process', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to activity', 'response to arsenic-containing substance', 'response to calcium ion', 'response to corticosterone', 'response to dexamethasone', 'response to electrical stimulus', 'response to inactivity', 'response to insulin', 'response to mercury ion', 'response to radiation']
Superoxide dismutase [Cu-Zn]
112
Superoxide dismutase [Cu-Zn]
112
9.6
78
0.13
P00441P00441['aging', 'anterograde axonal transport', 'apoptotic process', 'auditory receptor cell stereocilium organization', 'cellular iron ion homeostasis', 'cellular response to ATP', 'cellular response to cadmium ion', 'cellular response to potassium ion', 'ectopic germ cell programmed cell death', 'embryo implantation', 'glutathione metabolic process', 'heart contraction', 'hydrogen peroxide biosynthetic process', 'locomotory behavior', 'muscle cell cellular homeostasis', 'myeloid cell homeostasis', 'negative regulation of cholesterol biosynthetic process', 'negative regulation of developmental process', 'negative regulation of inflammatory response', 'negative regulation of neuron apoptotic process', 'negative regulation of reproductive process', 'neurofilament cytoskeleton organization', 'ovarian follicle development', 'peripheral nervous system myelin maintenance', 'placenta development', 'positive regulation of apoptotic process', 'positive regulation of catalytic activity', 'positive regulation of cytokine production', 'positive regulation of MAPK cascade', 'positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'positive regulation of phagocytosis', 'positive regulation of superoxide anion generation', 'reactive oxygen species metabolic process', 'regulation of blood pressure', 'regulation of GTPase activity', 'regulation of mitochondrial membrane potential', 'regulation of multicellular organism growth', 'regulation of organ growth', 'regulation of protein kinase activity', 'regulation of T cell differentiation in thymus', 'relaxation of vascular associated smooth muscle', 'removal of superoxide radicals', 'response to amphetamine', 'response to antibiotic', 'response to antipsychotic drug', 'response to axon injury', 'response to carbon monoxide', 'response to copper ion', 'response to ethanol', 'response to heat', 'response to hydrogen peroxide', 'response to nutrient levels', 'response to organic substance', 'response to superoxide', 'response to xenobiotic stimulus', 'retina homeostasis', 'retrograde axonal transport', 'sensory perception of sound', 'spermatogenesis', 'superoxide anion generation', 'superoxide metabolic process', 'thymus development', 'transmission of nerve impulse']['aging', 'anterograde axonal transport', 'apoptotic process', 'auditory receptor cell stereocilium organization', 'cellular iron ion homeostasis', 'cellular response to ATP', 'cellular response to cadmium ion', 'cellular response to potassium ion', 'ectopic germ cell programmed cell death', 'embryo implantation', 'glutathione metabolic process', 'heart contraction', 'hydrogen peroxide biosynthetic process', 'locomotory behavior', 'muscle cell cellular homeostasis', 'myeloid cell homeostasis', 'negative regulation of cholesterol biosynthetic process', 'negative regulation of developmental process', 'negative regulation of inflammatory response', 'negative regulation of neuron apoptotic process', 'negative regulation of reproductive process', 'neurofilament cytoskeleton organization', 'ovarian follicle development', 'peripheral nervous system myelin maintenance', 'placenta development', 'positive regulation of apoptotic process', 'positive regulation of catalytic activity', 'positive regulation of cytokine production', 'positive regulation of MAPK cascade', 'positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'positive regulation of phagocytosis', 'positive regulation of superoxide anion generation', 'reactive oxygen species metabolic process', 'regulation of blood pressure', 'regulation of GTPase activity', 'regulation of mitochondrial membrane potential', 'regulation of multicellular organism growth', 'regulation of organ growth', 'regulation of protein kinase activity', 'regulation of T cell differentiation in thymus', 'relaxation of vascular associated smooth muscle', 'removal of superoxide radicals', 'response to amphetamine', 'response to antibiotic', 'response to antipsychotic drug', 'response to axon injury', 'response to carbon monoxide', 'response to copper ion', 'response to ethanol', 'response to heat', 'response to hydrogen peroxide', 'response to nutrient levels', 'response to organic substance', 'response to superoxide', 'response to xenobiotic stimulus', 'retina homeostasis', 'retrograde axonal transport', 'sensory perception of sound', 'spermatogenesis', 'superoxide anion generation', 'superoxide metabolic process', 'thymus development', 'transmission of nerve impulse']
Glucocorticoid receptor
476
Glucocorticoid receptor
463
9.6
69
0.15
P04150P04150['adrenal gland development', 'apoptotic process', 'cell cycle', 'cell division', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin organization', 'chromosome segregation', 'glucocorticoid metabolic process', 'intracellular steroid hormone receptor signaling pathway', 'mammary gland duct morphogenesis', 'maternal behavior', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'signal transduction']['adrenal gland development', 'apoptotic process', 'cell cycle', 'cell division', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin organization', 'chromosome segregation', 'glucocorticoid metabolic process', 'intracellular steroid hormone receptor signaling pathway', 'mammary gland duct morphogenesis', 'maternal behavior', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'signal transduction']
Serine/threonine-protein kinase MRCK beta
41
Serine/threonine-protein kinase MRCK beta
41
9.6
68
0.15
Q9Y5S2Q9Y5S2['actin cytoskeleton reorganization', 'actomyosin structure organization', 'cell migration', 'cytoskeleton organization', 'establishment or maintenance of cell polarity', 'peptidyl-threonine phosphorylation', 'protein phosphorylation', 'signal transduction']['actin cytoskeleton reorganization', 'actomyosin structure organization', 'cell migration', 'cytoskeleton organization', 'establishment or maintenance of cell polarity', 'peptidyl-threonine phosphorylation', 'protein phosphorylation', 'signal transduction']
Insulin
95
Insulin
31
9.6
71
0.15
P01308P01308['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']
Glutamate receptor ionotropic, kainate 5
83
Glutamate receptor ionotropic, kainate 2
96
9.6
66
0.16
Q63273P42260['cellular response to glucose stimulus', 'chemical synaptic transmission', 'establishment of localization in cell', 'excitatory postsynaptic potential', 'modulation of chemical synaptic transmission', 'positive regulation of neuron apoptotic process', 'protein retention in ER lumen', 'receptor clustering', 'regulation of membrane potential', 'regulation of synaptic vesicle fusion to presynaptic active zone membrane', 'synaptic transmission, glutamatergic']['behavioral fear response', 'cellular calcium ion homeostasis', 'chemical synaptic transmission', 'detection of cold stimulus involved in thermoception', 'excitatory postsynaptic potential', 'inhibitory postsynaptic potential', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of synaptic transmission, glutamatergic', 'neuron apoptotic process', 'neuronal action potential', 'positive regulation of neuron apoptotic process', 'positive regulation of synaptic transmission', 'presynaptic modulation of chemical synaptic transmission', 'receptor clustering', 'regulation of JNK cascade', 'regulation of long-term neuronal synaptic plasticity', 'regulation of membrane potential', 'regulation of short-term neuronal synaptic plasticity', 'synaptic transmission, glutamatergic']
Pulmonary surfactant-associated protein B
298
Pulmonary surfactant-associated protein B
331
9.6
78
0.13
P50405P50405['respiratory gaseous exchange by respiratory system', 'sphingolipid metabolic process']['respiratory gaseous exchange by respiratory system', 'sphingolipid metabolic process']
Collagen alpha-1(II) chain
69
Collagen alpha-1(II) chain
86
9.6
54
0.19
P02458P02458['anterior head development', 'cartilage condensation', 'cartilage development', 'cartilage development involved in endochondral bone morphogenesis', 'cellular response to BMP stimulus', 'central nervous system development', 'chondrocyte differentiation', 'collagen fibril organization', 'embryonic skeletal joint morphogenesis', 'endochondral ossification', 'extracellular matrix organization', 'extrinsic apoptotic signaling pathway in absence of ligand', 'heart morphogenesis', 'inner ear morphogenesis', 'limb bud formation', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'notochord development', 'otic vesicle development', 'proteoglycan metabolic process', 'regulation of gene expression', 'roof of mouth development', 'sensory perception of sound', 'skeletal system development', 'tissue homeostasis', 'visual perception']['anterior head development', 'cartilage condensation', 'cartilage development', 'cartilage development involved in endochondral bone morphogenesis', 'cellular response to BMP stimulus', 'central nervous system development', 'chondrocyte differentiation', 'collagen fibril organization', 'embryonic skeletal joint morphogenesis', 'endochondral ossification', 'extracellular matrix organization', 'extrinsic apoptotic signaling pathway in absence of ligand', 'heart morphogenesis', 'inner ear morphogenesis', 'limb bud formation', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'notochord development', 'otic vesicle development', 'proteoglycan metabolic process', 'regulation of gene expression', 'roof of mouth development', 'sensory perception of sound', 'skeletal system development', 'tissue homeostasis', 'visual perception']
Coagulation factor X
342
Coagulation factor X
151
9.6
75
0.14
P00742P00742['blood coagulation', 'blood coagulation, common pathway', 'positive regulation of cell migration', 'positive regulation of protein kinase B signaling', 'proteolysis', 'zymogen activation']['blood coagulation', 'blood coagulation, common pathway', 'positive regulation of cell migration', 'positive regulation of protein kinase B signaling', 'proteolysis', 'zymogen activation']
Tumor protein p73
194
Tumor protein p73
194
9.6
65
0.16
O15350O15350['cell cycle', 'cellular response to DNA damage stimulus', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'kidney development', 'mismatch repair', 'negative regulation of cardiac muscle cell proliferation', 'negative regulation of cell population proliferation', 'negative regulation of neuron differentiation', 'positive regulation of apoptotic process', 'positive regulation of lung ciliated cell differentiation', 'positive regulation of MAPK cascade', 'positive regulation of oligodendrocyte differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein tetramerization', 'regulation of cell cycle', 'regulation of gene expression', 'regulation of mitotic cell cycle', 'regulation of transcription by RNA polymerase II', 'response to organonitrogen compound', 'response to xenobiotic stimulus']['cell cycle', 'cellular response to DNA damage stimulus', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'kidney development', 'mismatch repair', 'negative regulation of cardiac muscle cell proliferation', 'negative regulation of cell population proliferation', 'negative regulation of neuron differentiation', 'positive regulation of apoptotic process', 'positive regulation of lung ciliated cell differentiation', 'positive regulation of MAPK cascade', 'positive regulation of oligodendrocyte differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein tetramerization', 'regulation of cell cycle', 'regulation of gene expression', 'regulation of mitotic cell cycle', 'regulation of transcription by RNA polymerase II', 'response to organonitrogen compound', 'response to xenobiotic stimulus']
Zinc finger MYND domain-containing protein 11
535
Zinc finger MYND domain-containing protein 11
528
9.6
47
0.22
Q15326Q15326['cell cycle', 'chromatin organization', 'defense response to virus', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of JNK cascade', 'negative regulation of transcription, DNA-templated', 'regulation of signal transduction', 'regulation of transcription elongation from RNA polymerase II promoter']['cell cycle', 'chromatin organization', 'defense response to virus', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of JNK cascade', 'negative regulation of transcription, DNA-templated', 'regulation of signal transduction', 'regulation of transcription elongation from RNA polymerase II promoter']
Cyclin-dependent kinase 8
64
Cyclin-C
148
9.6
75
0.14
P49336P24863['protein phosphorylation']['G0 to G1 transition', 'negative regulation of Notch signaling pathway', 'positive regulation of transcription by RNA polymerase II', 'regulation of transcription by RNA polymerase II']
Alcohol dehydrogenase 1C
287
Alcohol dehydrogenase 1C
101
9.6
67
0.16
P00326P00326['ethanol oxidation', 'retinoic acid metabolic process', 'retinol metabolic process']['ethanol oxidation', 'retinoic acid metabolic process', 'retinol metabolic process']
Norrin
39
Norrin
93
9.6
75
0.14
Q00604Q00604['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']
Albumin
537
Albumin
582
9.6
73
0.14
P02769P02769['cellular response to starvation', 'maintenance of mitochondrion location', 'negative regulation of apoptotic process']['cellular response to starvation', 'maintenance of mitochondrion location', 'negative regulation of apoptotic process']
Peptidoglycan recognition protein 1
152
Peptidoglycan recognition protein 1
152
9.6
65
0.16
Q9GK12Q9GK12['defense response to bacterium', 'innate immune response', 'negative regulation of cytokine production', 'peptidoglycan catabolic process']['defense response to bacterium', 'innate immune response', 'negative regulation of cytokine production', 'peptidoglycan catabolic process']
Growth/differentiation factor 8
339
Growth/differentiation factor 8
309
9.6
89
0.12
O14793O14793['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'muscle organ development', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'muscle organ development', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
Glucocorticoid receptor
476
Glucocorticoid receptor
476
9.6
61
0.17
P06536P06536['adrenal gland development', 'aging', 'androgen metabolic process', 'brain development', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to magnesium ion', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin remodeling', 'circadian rhythm', 'epigenetic maintenance of chromatin in transcription-competent conformation', 'female pregnancy', 'glucocorticoid metabolic process', 'glucocorticoid receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lung development', 'mammary gland duct morphogenesis', 'maternal behavior', 'muscle atrophy', 'negative regulation of apoptotic process', 'negative regulation of synaptic plasticity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular permeability', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of dendritic spine development', 'positive regulation of glucocorticoid receptor signaling pathway', 'positive regulation of glutamate secretion', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'protein-containing complex assembly', 'regulation of cell population proliferation', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of glucose metabolic process', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to activity', 'response to arsenic-containing substance', 'response to calcium ion', 'response to corticosterone', 'response to dexamethasone', 'response to electrical stimulus', 'response to inactivity', 'response to insulin', 'response to mercury ion', 'response to radiation']['adrenal gland development', 'aging', 'androgen metabolic process', 'brain development', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to magnesium ion', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin remodeling', 'circadian rhythm', 'epigenetic maintenance of chromatin in transcription-competent conformation', 'female pregnancy', 'glucocorticoid metabolic process', 'glucocorticoid receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lung development', 'mammary gland duct morphogenesis', 'maternal behavior', 'muscle atrophy', 'negative regulation of apoptotic process', 'negative regulation of synaptic plasticity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular permeability', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of dendritic spine development', 'positive regulation of glucocorticoid receptor signaling pathway', 'positive regulation of glutamate secretion', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'protein-containing complex assembly', 'regulation of cell population proliferation', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of glucose metabolic process', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to activity', 'response to arsenic-containing substance', 'response to calcium ion', 'response to corticosterone', 'response to dexamethasone', 'response to electrical stimulus', 'response to inactivity', 'response to insulin', 'response to mercury ion', 'response to radiation']
Glycoprotein hormones alpha chain
111
Follitropin subunit beta
50
9.6
74
0.14
P01215P01225['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Neurturin
164
Neurturin
165
9.6
75
0.14
Q99748Q99748['MAPK cascade', 'nerve development', 'nervous system development', 'neural crest cell migration', 'neuron projection development', 'transmembrane receptor protein tyrosine kinase signaling pathway']['MAPK cascade', 'nerve development', 'nervous system development', 'neural crest cell migration', 'neuron projection development', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Glucocorticoid receptor
492
Glucocorticoid receptor
492
9.6
77
0.14
P06536P06536['adrenal gland development', 'aging', 'androgen metabolic process', 'brain development', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to magnesium ion', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin remodeling', 'circadian rhythm', 'epigenetic maintenance of chromatin in transcription-competent conformation', 'female pregnancy', 'glucocorticoid metabolic process', 'glucocorticoid receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lung development', 'mammary gland duct morphogenesis', 'maternal behavior', 'muscle atrophy', 'negative regulation of apoptotic process', 'negative regulation of synaptic plasticity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular permeability', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of dendritic spine development', 'positive regulation of glucocorticoid receptor signaling pathway', 'positive regulation of glutamate secretion', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'protein-containing complex assembly', 'regulation of cell population proliferation', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of glucose metabolic process', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to activity', 'response to arsenic-containing substance', 'response to calcium ion', 'response to corticosterone', 'response to dexamethasone', 'response to electrical stimulus', 'response to inactivity', 'response to insulin', 'response to mercury ion', 'response to radiation']['adrenal gland development', 'aging', 'androgen metabolic process', 'brain development', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to magnesium ion', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin remodeling', 'circadian rhythm', 'epigenetic maintenance of chromatin in transcription-competent conformation', 'female pregnancy', 'glucocorticoid metabolic process', 'glucocorticoid receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lung development', 'mammary gland duct morphogenesis', 'maternal behavior', 'muscle atrophy', 'negative regulation of apoptotic process', 'negative regulation of synaptic plasticity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular permeability', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of dendritic spine development', 'positive regulation of glucocorticoid receptor signaling pathway', 'positive regulation of glutamate secretion', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'protein-containing complex assembly', 'regulation of cell population proliferation', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of glucose metabolic process', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to activity', 'response to arsenic-containing substance', 'response to calcium ion', 'response to corticosterone', 'response to dexamethasone', 'response to electrical stimulus', 'response to inactivity', 'response to insulin', 'response to mercury ion', 'response to radiation']
Ketohexokinase
98
Ketohexokinase
99
9.5
90
0.12
P50053P50053['fructose metabolic process', 'regulation of glycogen metabolic process', 'response to fructose', 'response to glucose', 'response to insulin', 'response to sucrose', 'response to zinc ion']['fructose metabolic process', 'regulation of glycogen metabolic process', 'response to fructose', 'response to glucose', 'response to insulin', 'response to sucrose', 'response to zinc ion']
COP9 signalosome complex subunit 4
378
COP9 signalosome complex subunit 7a
181
9.6
74
0.14
Q9BT78Q9UBW8['protein deneddylation', 'protein neddylation', 'regulation of protein neddylation']['COP9 signalosome assembly', 'protein deneddylation', 'protein neddylation', 'regulation of protein neddylation']
Gamma-crystallin S
25
Gamma-crystallin S
23
9.6
78
0.13
O35486O35486['lens development in camera-type eye', 'morphogenesis of an epithelium', 'visual perception']['lens development in camera-type eye', 'morphogenesis of an epithelium', 'visual perception']
Ferritin heavy chain
131
Ferritin heavy chain
131
9.6
75
0.14
P02794P02794['cellular iron ion homeostasis', 'immune response', 'intracellular sequestering of iron ion', 'iron ion transport', 'negative regulation of cell population proliferation', 'negative regulation of fibroblast proliferation']['cellular iron ion homeostasis', 'immune response', 'intracellular sequestering of iron ion', 'iron ion transport', 'negative regulation of cell population proliferation', 'negative regulation of fibroblast proliferation']
Vascular endothelial growth factor A
77
Vascular endothelial growth factor A
130
9.6
64
0.16
P15692P15692['activation of protein kinase activity', 'angiogenesis', 'artery morphogenesis', 'basophil chemotaxis', 'branching involved in blood vessel morphogenesis', 'camera-type eye morphogenesis', 'cardiac muscle cell development', 'cardiac vascular smooth muscle cell development', 'cell maturation', 'cell migration involved in sprouting angiogenesis', 'cellular response to hypoxia', 'cellular response to vascular endothelial growth factor stimulus', 'cellular stress response to acid chemical', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'coronary vein morphogenesis', 'dopaminergic neuron differentiation', 'endothelial cell chemotaxis', 'epithelial cell differentiation', 'eye photoreceptor cell development', 'heart morphogenesis', 'in utero embryonic development', 'induction of positive chemotaxis', 'kidney development', 'lactation', 'lung development', 'lymph vessel morphogenesis', 'macrophage differentiation', 'mammary gland alveolus development', 'mesoderm development', 'monocyte differentiation', 'motor neuron migration', 'negative regulation of adherens junction organization', 'negative regulation of apoptotic process', 'negative regulation of blood-brain barrier permeability', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of establishment of endothelial barrier', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'outflow tract morphogenesis', 'ovarian follicle development', 'positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell migration by vascular endothelial growth factor signaling pathway', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway', 'positive regulation of cold-induced thermogenesis', 'positive regulation of CREB transcription factor activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of histone deacetylase activity', 'positive regulation of leukocyte migration', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of neuroblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of positive chemotaxis', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C signaling', 'positive regulation of protein kinase D signaling', 'positive regulation of protein localization to early endosome', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor internalization', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of trophoblast cell migration', 'positive regulation of vascular permeability', 'post-embryonic camera-type eye development', 'primitive erythrocyte differentiation', 'regulation of cell shape', 'regulation of nitric oxide mediated signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of transcription by RNA polymerase II', 'response to hypoxia', 'sprouting angiogenesis', 'surfactant homeostasis', 'tube formation', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway']['activation of protein kinase activity', 'angiogenesis', 'artery morphogenesis', 'basophil chemotaxis', 'branching involved in blood vessel morphogenesis', 'camera-type eye morphogenesis', 'cardiac muscle cell development', 'cardiac vascular smooth muscle cell development', 'cell maturation', 'cell migration involved in sprouting angiogenesis', 'cellular response to hypoxia', 'cellular response to vascular endothelial growth factor stimulus', 'cellular stress response to acid chemical', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'coronary vein morphogenesis', 'dopaminergic neuron differentiation', 'endothelial cell chemotaxis', 'epithelial cell differentiation', 'eye photoreceptor cell development', 'heart morphogenesis', 'in utero embryonic development', 'induction of positive chemotaxis', 'kidney development', 'lactation', 'lung development', 'lymph vessel morphogenesis', 'macrophage differentiation', 'mammary gland alveolus development', 'mesoderm development', 'monocyte differentiation', 'motor neuron migration', 'negative regulation of adherens junction organization', 'negative regulation of apoptotic process', 'negative regulation of blood-brain barrier permeability', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of establishment of endothelial barrier', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'outflow tract morphogenesis', 'ovarian follicle development', 'positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell migration by vascular endothelial growth factor signaling pathway', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway', 'positive regulation of cold-induced thermogenesis', 'positive regulation of CREB transcription factor activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of histone deacetylase activity', 'positive regulation of leukocyte migration', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of neuroblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of positive chemotaxis', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C signaling', 'positive regulation of protein kinase D signaling', 'positive regulation of protein localization to early endosome', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor internalization', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of trophoblast cell migration', 'positive regulation of vascular permeability', 'post-embryonic camera-type eye development', 'primitive erythrocyte differentiation', 'regulation of cell shape', 'regulation of nitric oxide mediated signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of transcription by RNA polymerase II', 'response to hypoxia', 'sprouting angiogenesis', 'surfactant homeostasis', 'tube formation', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway']
Pyruvate kinase PKM
317
Pyruvate kinase PKM
31
9.6
80
0.13
P11974P11974['positive regulation of cytoplasmic translation', 'positive regulation of sprouting angiogenesis']['positive regulation of cytoplasmic translation', 'positive regulation of sprouting angiogenesis']
Transforming growth factor beta-2 proprotein
379
Transforming growth factor beta-2 proprotein
413
9.6
77
0.14
P61812P61812['activation of protein kinase activity', 'ascending aorta morphogenesis', 'atrial septum morphogenesis', 'atrial septum primum morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'cardiac epithelial to mesenchymal transition', 'cardiac muscle cell proliferation', 'cardiac right ventricle morphogenesis', 'cardioblast differentiation', 'cell death', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'collagen fibril organization', 'cranial skeletal system development', 'dopamine biosynthetic process', 'embryo development ending in birth or egg hatching', 'embryonic digestive tract development', 'embryonic limb morphogenesis', 'endocardial cushion fusion', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'extrinsic apoptotic signaling pathway', 'eye development', 'generation of neurons', 'glial cell migration', 'hair follicle development', 'hair follicle morphogenesis', 'heart development', 'heart morphogenesis', 'heart valve morphogenesis', 'hemopoiesis', 'inner ear development', 'kidney development', 'male gonad development', 'membranous septum morphogenesis', 'negative regulation of alkaline phosphatase activity', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'negative regulation of gene expression', 'negative regulation of macrophage cytokine production', 'negative regulation of Ras protein signal transduction', 'neural retina development', 'neural tube closure', 'neuron development', 'neutrophil chemotaxis', 'odontogenesis', 'outflow tract septum morphogenesis', 'pathway-restricted SMAD protein phosphorylation', 'pharyngeal arch artery morphogenesis', 'positive regulation of cardioblast differentiation', 'positive regulation of cell adhesion mediated by integrin', 'positive regulation of cell cycle', 'positive regulation of cell division', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'positive regulation of heart contraction', 'positive regulation of immune response', 'positive regulation of integrin biosynthetic process', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of Notch signaling pathway', 'positive regulation of ossification', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of stress-activated MAPK cascade', 'positive regulation of timing of catagen', 'protein phosphorylation', 'pulmonary valve morphogenesis', 'regulation of apoptotic process involved in outflow tract morphogenesis', 'regulation of cell population proliferation', 'regulation of timing of catagen', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to progesterone', 'response to wounding', 'response to xenobiotic stimulus', 'salivary gland morphogenesis', 'secondary palate development', 'skeletal system development', 'SMAD protein signal transduction', 'somatic stem cell division', 'substantia propria of cornea development', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'uterus development', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis', 'wound healing']['activation of protein kinase activity', 'ascending aorta morphogenesis', 'atrial septum morphogenesis', 'atrial septum primum morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'cardiac epithelial to mesenchymal transition', 'cardiac muscle cell proliferation', 'cardiac right ventricle morphogenesis', 'cardioblast differentiation', 'cell death', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'collagen fibril organization', 'cranial skeletal system development', 'dopamine biosynthetic process', 'embryo development ending in birth or egg hatching', 'embryonic digestive tract development', 'embryonic limb morphogenesis', 'endocardial cushion fusion', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'extrinsic apoptotic signaling pathway', 'eye development', 'generation of neurons', 'glial cell migration', 'hair follicle development', 'hair follicle morphogenesis', 'heart development', 'heart morphogenesis', 'heart valve morphogenesis', 'hemopoiesis', 'inner ear development', 'kidney development', 'male gonad development', 'membranous septum morphogenesis', 'negative regulation of alkaline phosphatase activity', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'negative regulation of gene expression', 'negative regulation of macrophage cytokine production', 'negative regulation of Ras protein signal transduction', 'neural retina development', 'neural tube closure', 'neuron development', 'neutrophil chemotaxis', 'odontogenesis', 'outflow tract septum morphogenesis', 'pathway-restricted SMAD protein phosphorylation', 'pharyngeal arch artery morphogenesis', 'positive regulation of cardioblast differentiation', 'positive regulation of cell adhesion mediated by integrin', 'positive regulation of cell cycle', 'positive regulation of cell division', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'positive regulation of heart contraction', 'positive regulation of immune response', 'positive regulation of integrin biosynthetic process', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of Notch signaling pathway', 'positive regulation of ossification', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of stress-activated MAPK cascade', 'positive regulation of timing of catagen', 'protein phosphorylation', 'pulmonary valve morphogenesis', 'regulation of apoptotic process involved in outflow tract morphogenesis', 'regulation of cell population proliferation', 'regulation of timing of catagen', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to progesterone', 'response to wounding', 'response to xenobiotic stimulus', 'salivary gland morphogenesis', 'secondary palate development', 'skeletal system development', 'SMAD protein signal transduction', 'somatic stem cell division', 'substantia propria of cornea development', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'uterus development', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis', 'wound healing']
Complement C5
704
Complement C5
732
9.6
75
0.14
P01031P01031['cell surface receptor signaling pathway', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'G protein-coupled receptor signaling pathway', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']['cell surface receptor signaling pathway', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'G protein-coupled receptor signaling pathway', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']
Albumin
125
Albumin
538
9.6
70
0.15
P02768P02768['cellular response to starvation', 'maintenance of mitochondrion location', 'negative regulation of apoptotic process', 'negative regulation of programmed cell death', 'retina homeostasis']['cellular response to starvation', 'maintenance of mitochondrion location', 'negative regulation of apoptotic process', 'negative regulation of programmed cell death', 'retina homeostasis']
Prosaposin
484
Prosaposin
445
9.6
72
0.15
Q61207Q61207['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'antigen processing and presentation', 'cellular response to organic substance', 'ceramide metabolic process', 'cerebellar Purkinje cell differentiation', 'cochlea development', 'corneocyte development', 'cornified envelope assembly', 'developmental growth', 'epithelial cell differentiation involved in prostate gland development', 'galactosylceramide catabolic process', 'ganglioside GM1 transport to membrane', 'gene expression', 'glucosylceramide metabolic process', 'glycolipid metabolic process', 'inclusion body assembly', 'intracellular protein transport', 'lysosomal protein catabolic process', 'lysosomal transport', 'membrane lipid metabolic process', 'micturition', 'myelination', 'negative regulation of hydrogen peroxide-induced cell death', 'nervous system process', 'neuromuscular process controlling balance', 'NK T cell differentiation', 'positive regulation of beta-galactosidase activity', 'positive regulation of hydrolase activity', 'positive regulation of MAPK cascade', 'prostate gland growth', 'protein secretion', 'regulation of lipid metabolic process', 'regulation of MAPK cascade', 'sensory perception of sound', 'sphingolipid metabolic process', 'walking behavior']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'antigen processing and presentation', 'cellular response to organic substance', 'ceramide metabolic process', 'cerebellar Purkinje cell differentiation', 'cochlea development', 'corneocyte development', 'cornified envelope assembly', 'developmental growth', 'epithelial cell differentiation involved in prostate gland development', 'galactosylceramide catabolic process', 'ganglioside GM1 transport to membrane', 'gene expression', 'glucosylceramide metabolic process', 'glycolipid metabolic process', 'inclusion body assembly', 'intracellular protein transport', 'lysosomal protein catabolic process', 'lysosomal transport', 'membrane lipid metabolic process', 'micturition', 'myelination', 'negative regulation of hydrogen peroxide-induced cell death', 'nervous system process', 'neuromuscular process controlling balance', 'NK T cell differentiation', 'positive regulation of beta-galactosidase activity', 'positive regulation of hydrolase activity', 'positive regulation of MAPK cascade', 'prostate gland growth', 'protein secretion', 'regulation of lipid metabolic process', 'regulation of MAPK cascade', 'sensory perception of sound', 'sphingolipid metabolic process', 'walking behavior']
Fibrinogen beta chain
95
Fibrinogen gamma chain
49
9.6
73
0.14
P02675P02679['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Aldehyde dehydrogenase family 1 member A3
164
Aldehyde dehydrogenase family 1 member A3
467
9.6
81
0.13
P47895P47895['apoptotic process', 'embryonic camera-type eye development', 'embryonic eye morphogenesis', 'face development', 'Harderian gland development', 'inner ear morphogenesis', 'locomotory behavior', 'neuromuscular process controlling balance', 'nucleus accumbens development', 'olfactory pit development', 'optic cup morphogenesis involved in camera-type eye development', 'positive regulation of apoptotic process', 'protein homotetramerization', 'retinal metabolic process', 'retinoic acid biosynthetic process', 'retinoic acid metabolic process', 'retinol metabolic process', 'righting reflex']['apoptotic process', 'embryonic camera-type eye development', 'embryonic eye morphogenesis', 'face development', 'Harderian gland development', 'inner ear morphogenesis', 'locomotory behavior', 'neuromuscular process controlling balance', 'nucleus accumbens development', 'olfactory pit development', 'optic cup morphogenesis involved in camera-type eye development', 'positive regulation of apoptotic process', 'protein homotetramerization', 'retinal metabolic process', 'retinoic acid biosynthetic process', 'retinoic acid metabolic process', 'retinol metabolic process', 'righting reflex']
Fibrinogen alpha chain
64
Fibrinogen beta chain
95
9.6
82
0.13
P02671P02675['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']
Properdin
455
Properdin
127
9.6
58
0.18
P27918P27918['complement activation', 'complement activation, alternative pathway', 'defense response to bacterium', 'immune response', 'positive regulation of immune response', 'positive regulation of opsonization']['complement activation', 'complement activation, alternative pathway', 'defense response to bacterium', 'immune response', 'positive regulation of immune response', 'positive regulation of opsonization']
TNF receptor-associated factor 5
98
TNF receptor-associated factor 6
85
9.6
62
0.17
O00463Q9Y4K3['apoptotic process', 'interleukin-17-mediated signaling pathway', 'mRNA stabilization', 'positive regulation of cell population proliferation', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of JNK cascade', 'positive regulation of NF-kappaB transcription factor activity', 'protein K63-linked ubiquitination', 'regulation of apoptotic process', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'signal transduction', 'signal transduction involved in regulation of gene expression', 'tumor necrosis factor-mediated signaling pathway']['activation of NF-kappaB-inducing kinase activity', 'activation of protein kinase activity', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'bone resorption', 'cell development', 'cellular response to cytokine stimulus', 'cellular response to DNA damage stimulus', 'cellular response to lipopolysaccharide', 'cytoplasmic pattern recognition receptor signaling pathway', 'Fc-epsilon receptor signaling pathway', 'I-kappaB kinase/NF-kappaB signaling', 'in utero embryonic development', 'interleukin-1-mediated signaling pathway', 'interleukin-17-mediated signaling pathway', 'MyD88-dependent toll-like receptor signaling pathway', 'myeloid dendritic cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'odontogenesis of dentin-containing tooth', 'ossification', 'osteoclast differentiation', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-2 production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of JUN kinase activity', 'positive regulation of leukocyte adhesion to vascular endothelial cell', 'positive regulation of lipopolysaccharide-mediated signaling pathway', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of osteoclast differentiation', 'positive regulation of protein ubiquitination', 'positive regulation of T cell cytokine production', 'positive regulation of T cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'protein autoubiquitination', 'protein K63-linked ubiquitination', 'protein polyubiquitination', 'regulation of apoptotic process', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of immunoglobulin production', 'response to interleukin-1', 'stimulatory C-type lectin receptor signaling pathway', 'T cell receptor signaling pathway', 'T-helper 1 type immune response', 'tumor necrosis factor-mediated signaling pathway']
Nuclear receptor ROR-gamma
320
Nuclear receptor ROR-gamma
393
9.6
59
0.18
P51449P51449['adipose tissue development', 'cellular response to sterol', 'circadian regulation of gene expression', 'lymph node development', 'negative regulation of thymocyte apoptotic process', 'negative regulation of transcription by RNA polymerase II', "Peyer's patch development", 'positive regulation of circadian rhythm', 'positive regulation of transcription, DNA-templated', 'regulation of fat cell differentiation', 'regulation of glucose metabolic process', 'regulation of steroid metabolic process', 'regulation of transcription by RNA polymerase II', 'T-helper 17 cell differentiation', 'T-helper cell differentiation', 'xenobiotic metabolic process']['adipose tissue development', 'cellular response to sterol', 'circadian regulation of gene expression', 'lymph node development', 'negative regulation of thymocyte apoptotic process', 'negative regulation of transcription by RNA polymerase II', "Peyer's patch development", 'positive regulation of circadian rhythm', 'positive regulation of transcription, DNA-templated', 'regulation of fat cell differentiation', 'regulation of glucose metabolic process', 'regulation of steroid metabolic process', 'regulation of transcription by RNA polymerase II', 'T-helper 17 cell differentiation', 'T-helper cell differentiation', 'xenobiotic metabolic process']
Prothrombin
391
Pancreatic trypsin inhibitor
49
9.6
99
0.11
P00734P00974['acute-phase response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'blood coagulation', 'blood coagulation, common pathway', 'cell surface receptor signaling pathway', 'cytolysis by host of symbiont cells', 'fibrinolysis', 'negative regulation of astrocyte differentiation', 'negative regulation of blood coagulation', 'negative regulation of cytokine production involved in inflammatory response', 'negative regulation of fibrinolysis', 'negative regulation of platelet activation', 'negative regulation of proteolysis', 'neutrophil-mediated killing of gram-negative bacterium', 'platelet activation', 'positive regulation of blood coagulation', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of lipid kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to nucleus', 'positive regulation of protein phosphorylation', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of release of sequestered calcium ion into cytosol', 'proteolysis', 'regulation of blood coagulation', 'regulation of cell shape', 'regulation of cytosolic calcium ion concentration', 'response to wounding', 'zymogen activation']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Fibrinogen beta chain
316
Fibrinogen gamma chain
165
9.6
71
0.15
P02675Q53Y18['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Non-homologous end-joining factor 1
148
Non-homologous end-joining factor 1
202
9.5
63
0.17
Q9H9Q4Q9H9Q4['B cell differentiation', 'central nervous system development', 'DNA ligation involved in DNA repair', 'double-strand break repair via nonhomologous end joining', 'immunoglobulin V(D)J recombination', 'positive regulation of ligase activity', 'response to ionizing radiation', 'T cell differentiation']['B cell differentiation', 'central nervous system development', 'DNA ligation involved in DNA repair', 'double-strand break repair via nonhomologous end joining', 'immunoglobulin V(D)J recombination', 'positive regulation of ligase activity', 'response to ionizing radiation', 'T cell differentiation']
D-3-phosphoglycerate dehydrogenase
116
D-3-phosphoglycerate dehydrogenase
281
9.5
97
0.11
O43175O43175['brain development', 'G1 to G0 transition', 'gamma-aminobutyric acid metabolic process', 'glial cell development', 'glutamine metabolic process', 'glycine metabolic process', 'L-serine biosynthetic process', 'neural tube development', 'neuron projection development', 'regulation of gene expression', 'spinal cord development', 'taurine metabolic process', 'threonine metabolic process']['brain development', 'G1 to G0 transition', 'gamma-aminobutyric acid metabolic process', 'glial cell development', 'glutamine metabolic process', 'glycine metabolic process', 'L-serine biosynthetic process', 'neural tube development', 'neuron projection development', 'regulation of gene expression', 'spinal cord development', 'taurine metabolic process', 'threonine metabolic process']
Glucocorticoid receptor
473
Glucocorticoid receptor
473
9.6
78
0.13
P04150P04150['adrenal gland development', 'apoptotic process', 'cell cycle', 'cell division', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin organization', 'chromosome segregation', 'glucocorticoid metabolic process', 'intracellular steroid hormone receptor signaling pathway', 'mammary gland duct morphogenesis', 'maternal behavior', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'signal transduction']['adrenal gland development', 'apoptotic process', 'cell cycle', 'cell division', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin organization', 'chromosome segregation', 'glucocorticoid metabolic process', 'intracellular steroid hormone receptor signaling pathway', 'mammary gland duct morphogenesis', 'maternal behavior', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'signal transduction']
Mineralocorticoid receptor
645
Mineralocorticoid receptor
658
9.5
67
0.16
P08235P08235['intracellular steroid hormone receptor signaling pathway', 'positive regulation of NIK/NF-kappaB signaling', 'regulation of transcription by RNA polymerase II', 'signal transduction']['intracellular steroid hormone receptor signaling pathway', 'positive regulation of NIK/NF-kappaB signaling', 'regulation of transcription by RNA polymerase II', 'signal transduction']
DNA polymerase subunit gamma-1
548
DNA polymerase subunit gamma-2, mitochondrial
399
9.5
61
0.17
P54098Q9UHN1['base-excision repair, gap-filling', 'DNA metabolic process', 'DNA-templated DNA replication', 'mitochondrial DNA replication']['DNA repair', 'DNA-templated DNA replication', 'in utero embryonic development', 'mitochondrial DNA replication', 'mitochondrion morphogenesis', 'positive regulation of DNA-directed DNA polymerase activity', 'respiratory electron transport chain']
Placenta growth factor
52
Placenta growth factor
77
9.6
68
0.15
P49763P49763['animal organ regeneration', 'cell differentiation', 'cell-cell signaling', 'cellular response to hormone stimulus', 'female pregnancy', 'induction of positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell proliferation', 'positive regulation of mast cell chemotaxis', 'positive regulation of protein phosphorylation', 'response to hypoxia', 'response to xenobiotic stimulus', 'signal transduction', 'sprouting angiogenesis', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor signaling pathway']['animal organ regeneration', 'cell differentiation', 'cell-cell signaling', 'cellular response to hormone stimulus', 'female pregnancy', 'induction of positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell proliferation', 'positive regulation of mast cell chemotaxis', 'positive regulation of protein phosphorylation', 'response to hypoxia', 'response to xenobiotic stimulus', 'signal transduction', 'sprouting angiogenesis', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor signaling pathway']
Glucocorticoid receptor
473
Glucocorticoid receptor
473
9.5
78
0.13
P79269P79269['cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'chromatin organization', 'positive regulation of transcription by RNA polymerase II']['cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'chromatin organization', 'positive regulation of transcription by RNA polymerase II']
Tumor necrosis factor ligand superfamily member 13B
245
Tumor necrosis factor ligand superfamily member 13B
232
9.5
96
0.11
Q9Y275Q9Y275['B cell costimulation', 'B cell differentiation', 'B cell homeostasis', 'B cell proliferation', 'germinal center formation', 'positive regulation of B cell proliferation', 'positive regulation of germinal center formation', 'positive regulation of T cell proliferation', 'signal transduction', 'T cell costimulation', 'T cell proliferation', 'tumor necrosis factor-mediated signaling pathway']['B cell costimulation', 'B cell differentiation', 'B cell homeostasis', 'B cell proliferation', 'germinal center formation', 'positive regulation of B cell proliferation', 'positive regulation of germinal center formation', 'positive regulation of T cell proliferation', 'signal transduction', 'T cell costimulation', 'T cell proliferation', 'tumor necrosis factor-mediated signaling pathway']
Estrogen receptor
221
Estrogen receptor
221
9.6
66
0.16
P03372P03372['androgen metabolic process', 'antral ovarian follicle growth', 'cellular response to estradiol stimulus', 'cellular response to estrogen stimulus', 'chromatin remodeling', 'epithelial cell development', 'epithelial cell proliferation involved in mammary gland duct elongation', 'fibroblast proliferation', 'intracellular estrogen receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'male gonad development', 'mammary gland alveolus development', 'mammary gland branching involved in pregnancy', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of gene expression', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of miRNA maturation', 'negative regulation of transcription by RNA polymerase II', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of fibroblast proliferation', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of phospholipase C activity', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis', 'prostate epithelial cord elongation', 'protein localization to chromatin', 'regulation of branching involved in prostate gland morphogenesis', 'regulation of epithelial cell apoptotic process', 'regulation of inflammatory response', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to estradiol', 'response to estrogen', 'signal transduction', 'stem cell differentiation', 'transcription by RNA polymerase II', 'uterus development', 'vagina development']['androgen metabolic process', 'antral ovarian follicle growth', 'cellular response to estradiol stimulus', 'cellular response to estrogen stimulus', 'chromatin remodeling', 'epithelial cell development', 'epithelial cell proliferation involved in mammary gland duct elongation', 'fibroblast proliferation', 'intracellular estrogen receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'male gonad development', 'mammary gland alveolus development', 'mammary gland branching involved in pregnancy', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of gene expression', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of miRNA maturation', 'negative regulation of transcription by RNA polymerase II', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of fibroblast proliferation', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of phospholipase C activity', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis', 'prostate epithelial cord elongation', 'protein localization to chromatin', 'regulation of branching involved in prostate gland morphogenesis', 'regulation of epithelial cell apoptotic process', 'regulation of inflammatory response', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to estradiol', 'response to estrogen', 'signal transduction', 'stem cell differentiation', 'transcription by RNA polymerase II', 'uterus development', 'vagina development']
Peptidoglycan recognition protein 1
152
Peptidoglycan recognition protein 1
28
9.6
70
0.15
Q9GK12Q9GK12['defense response to bacterium', 'innate immune response', 'negative regulation of cytokine production', 'peptidoglycan catabolic process']['defense response to bacterium', 'innate immune response', 'negative regulation of cytokine production', 'peptidoglycan catabolic process']
Microtubule-associated protein RP/EB family member 1
228
Microtubule-associated protein RP/EB family member 1
228
9.5
62
0.17
Q15691Q15691['attachment of mitotic spindle microtubules to kinetochore', 'cell division', 'cell migration', 'establishment of mitotic spindle orientation', 'microtubule bundle formation', 'microtubule polymerization', 'negative regulation of microtubule polymerization', 'non-motile cilium assembly', 'positive regulation of microtubule plus-end binding', 'positive regulation of microtubule polymerization', 'protein localization', 'protein localization to astral microtubule', 'protein localization to centrosome', 'protein localization to microtubule', 'protein localization to microtubule plus-end', 'regulation of microtubule polymerization or depolymerization', 'spindle assembly']['attachment of mitotic spindle microtubules to kinetochore', 'cell division', 'cell migration', 'establishment of mitotic spindle orientation', 'microtubule bundle formation', 'microtubule polymerization', 'negative regulation of microtubule polymerization', 'non-motile cilium assembly', 'positive regulation of microtubule plus-end binding', 'positive regulation of microtubule polymerization', 'protein localization', 'protein localization to astral microtubule', 'protein localization to centrosome', 'protein localization to microtubule', 'protein localization to microtubule plus-end', 'regulation of microtubule polymerization or depolymerization', 'spindle assembly']
Coagulation factor IX
291
Coagulation factor IX
125
9.5
69
0.15
P16293P16293['blood coagulation', 'proteolysis', 'zymogen activation']['blood coagulation', 'proteolysis', 'zymogen activation']
Cytochrome c oxidase subunit 6B1
40
Cytochrome c oxidase subunit 6B1
40
9.5
58
0.18
P00429P00429['oxidative phosphorylation']['oxidative phosphorylation']
Kinetochore-associated protein DSN1 homolog
191
Kinetochore-associated protein NSL1 homolog
53
9.5
69
0.15
Q9H410Q96IY1['cell division', 'mitotic sister chromatid segregation']['cell division', 'mitotic sister chromatid segregation']
ATP-citrate synthase
913
ATP-citrate synthase
913
9.5
103
0.1
P53396P53396['acetyl-CoA biosynthetic process', 'cholesterol biosynthetic process', 'citrate metabolic process', 'coenzyme A metabolic process', 'fatty acid biosynthetic process', 'lipid biosynthetic process', 'oxaloacetate metabolic process']['acetyl-CoA biosynthetic process', 'cholesterol biosynthetic process', 'citrate metabolic process', 'coenzyme A metabolic process', 'fatty acid biosynthetic process', 'lipid biosynthetic process', 'oxaloacetate metabolic process']
Vasopressin-neurophysin 2-copeptin
110
Vasopressin-neurophysin 2-copeptin
105
9.5
100
0.1
P01180P01180['vasoconstriction']['vasoconstriction']
Mineralocorticoid receptor
639
Mineralocorticoid receptor
639
9.6
63
0.17
P08235P08235['intracellular steroid hormone receptor signaling pathway', 'positive regulation of NIK/NF-kappaB signaling', 'regulation of transcription by RNA polymerase II', 'signal transduction']['intracellular steroid hormone receptor signaling pathway', 'positive regulation of NIK/NF-kappaB signaling', 'regulation of transcription by RNA polymerase II', 'signal transduction']
Fragile X messenger ribonucleoprotein 1
78
Fragile X messenger ribonucleoprotein 1
99
9.5
70
0.15
Q06787Q06787['cellular response to virus', 'DNA repair', 'gene silencing by RNA', 'glutamate receptor signaling pathway', 'modulation by host of viral RNA genome replication', 'mRNA processing', 'mRNA transport', 'negative regulation of cytoplasmic translation', 'negative regulation of long-term synaptic depression', 'negative regulation of mRNA catabolic process', 'negative regulation of synaptic vesicle exocytosis', 'negative regulation of translation', 'negative regulation of translational initiation', 'negative regulation of voltage-gated calcium channel activity', 'nervous system development', 'positive regulation of dendritic spine development', 'positive regulation of filopodium assembly', 'positive regulation of intracellular transport of viral material', 'positive regulation of miRNA-mediated gene silencing', 'positive regulation of mRNA binding', 'positive regulation of proteasomal protein catabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of receptor internalization', 'positive regulation of response to DNA damage stimulus', 'positive regulation of translation', 'regulation of alternative mRNA splicing, via spliceosome', 'regulation of dendritic spine development', 'regulation of filopodium assembly', 'regulation of miRNA-mediated gene silencing', 'regulation of mRNA stability', 'regulation of neuronal action potential', 'regulation of neurotransmitter secretion', 'RNA splicing']['cellular response to virus', 'DNA repair', 'gene silencing by RNA', 'glutamate receptor signaling pathway', 'modulation by host of viral RNA genome replication', 'mRNA processing', 'mRNA transport', 'negative regulation of cytoplasmic translation', 'negative regulation of long-term synaptic depression', 'negative regulation of mRNA catabolic process', 'negative regulation of synaptic vesicle exocytosis', 'negative regulation of translation', 'negative regulation of translational initiation', 'negative regulation of voltage-gated calcium channel activity', 'nervous system development', 'positive regulation of dendritic spine development', 'positive regulation of filopodium assembly', 'positive regulation of intracellular transport of viral material', 'positive regulation of miRNA-mediated gene silencing', 'positive regulation of mRNA binding', 'positive regulation of proteasomal protein catabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of receptor internalization', 'positive regulation of response to DNA damage stimulus', 'positive regulation of translation', 'regulation of alternative mRNA splicing, via spliceosome', 'regulation of dendritic spine development', 'regulation of filopodium assembly', 'regulation of miRNA-mediated gene silencing', 'regulation of mRNA stability', 'regulation of neuronal action potential', 'regulation of neurotransmitter secretion', 'RNA splicing']
Fibrinogen alpha chain
180
Fibrinogen beta chain
227
9.6
73
0.14
P02671P02675['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']
Chymotrypsinogen A
42
Pancreatic trypsin inhibitor
49
9.5
99
0.11
P00766P00974['digestion', 'proteolysis']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Lysine-specific demethylase 2A
333
Lysine-specific demethylase 2A
477
9.5
66
0.16
F6YRW4F6YRW4['chromatin organization', 'circadian regulation of gene expression', 'double-strand break repair via nonhomologous end joining', 'histone H3-K36 demethylation', 'negative regulation of transcription by competitive promoter binding', 'regulation of circadian rhythm']['chromatin organization', 'circadian regulation of gene expression', 'double-strand break repair via nonhomologous end joining', 'histone H3-K36 demethylation', 'negative regulation of transcription by competitive promoter binding', 'regulation of circadian rhythm']
Lactotransferrin
390
Lactotransferrin
500
9.5
85
0.12
P24627P24627['antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'bone morphogenesis', 'defense response to Gram-negative bacterium', 'innate immune response in mucosa', 'iron ion homeostasis', 'iron ion transport', 'killing of cells of another organism', 'membrane disruption in another organism', 'negative regulation by host of viral process', 'negative regulation of apoptotic process', 'negative regulation of ATP-dependent activity', 'negative regulation of cysteine-type endopeptidase activity', 'negative regulation of lipopolysaccharide-mediated signaling pathway', 'negative regulation of osteoclast development', 'negative regulation of single-species biofilm formation in or on host organism', 'negative regulation of tumor necrosis factor (ligand) superfamily member 11 production', 'negative regulation of viral genome replication', 'ossification', 'positive regulation of bone mineralization involved in bone maturation', 'positive regulation of chondrocyte proliferation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of osteoblast differentiation', 'positive regulation of osteoblast proliferation', 'positive regulation of toll-like receptor 4 signaling pathway', 'proteolysis', 'regulation of cytokine production', 'regulation of tumor necrosis factor production']['antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'bone morphogenesis', 'defense response to Gram-negative bacterium', 'innate immune response in mucosa', 'iron ion homeostasis', 'iron ion transport', 'killing of cells of another organism', 'membrane disruption in another organism', 'negative regulation by host of viral process', 'negative regulation of apoptotic process', 'negative regulation of ATP-dependent activity', 'negative regulation of cysteine-type endopeptidase activity', 'negative regulation of lipopolysaccharide-mediated signaling pathway', 'negative regulation of osteoclast development', 'negative regulation of single-species biofilm formation in or on host organism', 'negative regulation of tumor necrosis factor (ligand) superfamily member 11 production', 'negative regulation of viral genome replication', 'ossification', 'positive regulation of bone mineralization involved in bone maturation', 'positive regulation of chondrocyte proliferation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of osteoblast differentiation', 'positive regulation of osteoblast proliferation', 'positive regulation of toll-like receptor 4 signaling pathway', 'proteolysis', 'regulation of cytokine production', 'regulation of tumor necrosis factor production']
Proprotein convertase subtilisin/kexin type 9
375
Low-density lipoprotein receptor
329
9.5
71
0.15
Q8NBP7P01130['apoptotic process', 'cellular response to insulin stimulus', 'cellular response to starvation', 'cholesterol homeostasis', 'cholesterol metabolic process', 'kidney development', 'lipoprotein metabolic process', 'liver development', 'low-density lipoprotein particle receptor catabolic process', 'lysosomal transport', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of low-density lipoprotein particle receptor binding', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of receptor internalization', 'negative regulation of receptor recycling', 'negative regulation of receptor-mediated endocytosis involved in cholesterol transport', 'negative regulation of sodium ion transmembrane transporter activity', 'neurogenesis', 'neuron differentiation', 'phospholipid metabolic process', 'positive regulation of low-density lipoprotein particle receptor catabolic process', 'positive regulation of neuron apoptotic process', 'positive regulation of receptor internalization', 'protein autoprocessing', 'regulation of neuron apoptotic process', 'regulation of signaling receptor activity', 'triglyceride metabolic process']['amyloid-beta clearance', 'amyloid-beta clearance by cellular catabolic process', 'artery morphogenesis', 'cellular response to fatty acid', 'cellular response to low-density lipoprotein particle stimulus', 'cholesterol homeostasis', 'cholesterol import', 'cholesterol metabolic process', 'cholesterol transport', 'endocytosis', 'high-density lipoprotein particle clearance', 'intestinal cholesterol absorption', 'lipid metabolic process', 'lipoprotein catabolic process', 'long-term memory', 'low-density lipoprotein particle clearance', 'negative regulation of amyloid fibril formation', 'negative regulation of astrocyte activation', 'negative regulation of gene expression', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of microglial cell activation', 'negative regulation of protein metabolic process', 'negative regulation of receptor recycling', 'phagocytosis', 'phospholipid transport', 'plasma lipoprotein particle clearance', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of lysosomal protein catabolic process', 'positive regulation of triglyceride biosynthetic process', 'receptor-mediated endocytosis', 'receptor-mediated endocytosis involved in cholesterol transport', 'regulation of cholesterol metabolic process', 'regulation of phosphatidylcholine catabolic process', 'regulation of protein metabolic process', 'response to caloric restriction']
Protein SEC13 homolog
299
Protein SEC13 homolog
299
9.6
56
0.19
P55735P55735['COPII-coated vesicle budding', 'COPII-coated vesicle cargo loading', 'intracellular protein transport', 'mRNA transport', 'negative regulation of TORC1 signaling', 'nucleocytoplasmic transport', 'positive regulation of TOR signaling', 'positive regulation of TORC1 signaling', 'protein exit from endoplasmic reticulum', 'protein import into nucleus']['COPII-coated vesicle budding', 'COPII-coated vesicle cargo loading', 'intracellular protein transport', 'mRNA transport', 'negative regulation of TORC1 signaling', 'nucleocytoplasmic transport', 'positive regulation of TOR signaling', 'positive regulation of TORC1 signaling', 'protein exit from endoplasmic reticulum', 'protein import into nucleus']
Hematopoietic prostaglandin D synthase
101
Hematopoietic prostaglandin D synthase
101
9.6
51
0.2
O60760O60760['glutathione metabolic process', 'locomotory behavior', 'negative regulation of male germ cell proliferation', 'prostaglandin biosynthetic process', 'prostaglandin metabolic process', 'signal transduction']['glutathione metabolic process', 'locomotory behavior', 'negative regulation of male germ cell proliferation', 'prostaglandin biosynthetic process', 'prostaglandin metabolic process', 'signal transduction']
Tumor protein 63
244
Tumor protein 63
244
9.5
63
0.17
Q9H3D4Q9H3D4['apoptotic process', 'cellular response to DNA damage stimulus', 'cellular senescence', 'chromatin remodeling', 'cloacal septation', 'cranial skeletal system development', 'ectoderm and mesoderm interaction', 'embryonic forelimb morphogenesis', 'embryonic hindlimb morphogenesis', 'epidermal cell division', 'epithelial cell development', 'establishment of planar polarity', 'establishment of skin barrier', 'female genitalia morphogenesis', 'hair follicle morphogenesis', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'keratinocyte differentiation', 'keratinocyte proliferation', 'multicellular organism aging', 'negative regulation of cellular senescence', 'negative regulation of intracellular estrogen receptor signaling pathway', 'negative regulation of keratinocyte differentiation', 'negative regulation of mesoderm development', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron apoptotic process', 'Notch signaling pathway', 'odontogenesis of dentin-containing tooth', 'polarized epithelial cell differentiation', 'positive regulation of apoptotic signaling pathway', 'positive regulation of cell cycle G1/S phase transition', 'positive regulation of fibroblast apoptotic process', 'positive regulation of keratinocyte proliferation', 'positive regulation of Notch signaling pathway', 'positive regulation of osteoblast differentiation', 'positive regulation of somatic stem cell population maintenance', 'positive regulation of stem cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'post-anal tail morphogenesis', 'prostatic bud formation', 'protein tetramerization', 'proximal/distal pattern formation', 'regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'regulation of epidermal cell division', 'regulation of transcription by RNA polymerase II', 'skeletal system development', 'skin morphogenesis', 'spermatogenesis', 'squamous basal epithelial stem cell differentiation involved in prostate gland acinus development', 'stem cell proliferation', 'sympathetic nervous system development', 'transcription by RNA polymerase II']['apoptotic process', 'cellular response to DNA damage stimulus', 'cellular senescence', 'chromatin remodeling', 'cloacal septation', 'cranial skeletal system development', 'ectoderm and mesoderm interaction', 'embryonic forelimb morphogenesis', 'embryonic hindlimb morphogenesis', 'epidermal cell division', 'epithelial cell development', 'establishment of planar polarity', 'establishment of skin barrier', 'female genitalia morphogenesis', 'hair follicle morphogenesis', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'keratinocyte differentiation', 'keratinocyte proliferation', 'multicellular organism aging', 'negative regulation of cellular senescence', 'negative regulation of intracellular estrogen receptor signaling pathway', 'negative regulation of keratinocyte differentiation', 'negative regulation of mesoderm development', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron apoptotic process', 'Notch signaling pathway', 'odontogenesis of dentin-containing tooth', 'polarized epithelial cell differentiation', 'positive regulation of apoptotic signaling pathway', 'positive regulation of cell cycle G1/S phase transition', 'positive regulation of fibroblast apoptotic process', 'positive regulation of keratinocyte proliferation', 'positive regulation of Notch signaling pathway', 'positive regulation of osteoblast differentiation', 'positive regulation of somatic stem cell population maintenance', 'positive regulation of stem cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'post-anal tail morphogenesis', 'prostatic bud formation', 'protein tetramerization', 'proximal/distal pattern formation', 'regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'regulation of epidermal cell division', 'regulation of transcription by RNA polymerase II', 'skeletal system development', 'skin morphogenesis', 'spermatogenesis', 'squamous basal epithelial stem cell differentiation involved in prostate gland acinus development', 'stem cell proliferation', 'sympathetic nervous system development', 'transcription by RNA polymerase II']
Guanine nucleotide-binding protein G(i) subunit alpha-3
305
Guanine nucleotide-binding protein G(i) subunit alpha-3
305
9.6
50
0.21
P08754P08754['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'brain development', 'cell cycle', 'cell division', 'dopamine receptor signaling pathway', 'GTP metabolic process', 'negative regulation of adenylate cyclase activity', 'negative regulation of apoptotic signaling pathway', 'positive regulation of macroautophagy', 'positive regulation of NAD(P)H oxidase activity', 'positive regulation of superoxide anion generation', 'positive regulation of vascular associated smooth muscle cell proliferation', 'vesicle fusion']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'brain development', 'cell cycle', 'cell division', 'dopamine receptor signaling pathway', 'GTP metabolic process', 'negative regulation of adenylate cyclase activity', 'negative regulation of apoptotic signaling pathway', 'positive regulation of macroautophagy', 'positive regulation of NAD(P)H oxidase activity', 'positive regulation of superoxide anion generation', 'positive regulation of vascular associated smooth muscle cell proliferation', 'vesicle fusion']
Transcription regulator protein BACH2
20
Transcription regulator protein BACH2
58
9.5
77
0.14
Q9BYV9Q9BYV9['import into nucleus', 'negative regulation of transcription by RNA polymerase II', 'primary adaptive immune response involving T cells and B cells', 'regulation of transcription by RNA polymerase II']['import into nucleus', 'negative regulation of transcription by RNA polymerase II', 'primary adaptive immune response involving T cells and B cells', 'regulation of transcription by RNA polymerase II']
Spindle and kinetochore-associated protein 1
10
Spindle and kinetochore-associated protein 1
10
9.5
66
0.16
Q96BD8Q96BD8['cell division', 'chromosome segregation', 'mitotic cell cycle', 'regulation of microtubule polymerization or depolymerization']['cell division', 'chromosome segregation', 'mitotic cell cycle', 'regulation of microtubule polymerization or depolymerization']
Fibrinogen beta chain
227
Fibrinogen gamma chain
161
9.6
70
0.15
P02675Q53Y18['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
4-trimethylaminobutyraldehyde dehydrogenase
443
4-trimethylaminobutyraldehyde dehydrogenase
484
9.5
90
0.12
P49189P49189['carnitine biosynthetic process', 'cellular aldehyde metabolic process', 'hormone metabolic process', 'neurotransmitter biosynthetic process', 'protein homotetramerization']['carnitine biosynthetic process', 'cellular aldehyde metabolic process', 'hormone metabolic process', 'neurotransmitter biosynthetic process', 'protein homotetramerization']
Insulin
95
Insulin
43
9.5
55
0.19
P01308P01308['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']
Eukaryotic translation initiation factor 3 subunit J
188
Eukaryotic translation initiation factor 3 subunit J
188
9.5
81
0.13
O75822O75822['formation of cytoplasmic translation initiation complex', 'translational initiation']['formation of cytoplasmic translation initiation complex', 'translational initiation']
Fibrinogen alpha chain
180
Fibrinogen gamma chain
165
9.5
81
0.13
P02671Q53Y18['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Cyclin-dependent kinase 5
53
Cyclin-dependent kinase 5 activator 1
261
9.5
79
0.13
Q00535Q15078['axon extension', 'axonogenesis', 'behavioral response to cocaine', 'calcium ion import', 'cell division', 'cell-matrix adhesion', 'cellular response to amyloid-beta', 'central nervous system neuron development', 'cerebellar cortex formation', 'chemical synaptic transmission', 'corpus callosum development', 'cortical actin cytoskeleton organization', 'dendrite morphogenesis', 'excitatory postsynaptic potential', 'hippocampus development', 'histone phosphorylation', 'intracellular protein transport', 'layer formation in cerebral cortex', 'microtubule cytoskeleton organization', 'mitochondrion organization', 'motor neuron axon guidance', 'negative regulation of axon extension', 'negative regulation of cell cycle', 'negative regulation of neuron death', 'negative regulation of protein export from nucleus', 'negative regulation of protein ubiquitination', 'negative regulation of proteolysis', 'negative regulation of synaptic plasticity', 'negative regulation of transcription, DNA-templated', 'neuron apoptotic process', 'neuron differentiation', 'neuron migration', 'neuron projection development', 'nucleocytoplasmic transport', 'oligodendrocyte differentiation', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'phosphorylation', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of calcium ion-dependent exocytosis', 'positive regulation of glial cell apoptotic process', 'positive regulation of neuron apoptotic process', 'positive regulation of protein binding', 'positive regulation of protein kinase activity', 'positive regulation of protein targeting to membrane', 'positive regulation of voltage-gated calcium channel activity', 'protein autophosphorylation', 'protein localization to synapse', 'protein phosphorylation', 'receptor catabolic process', 'receptor clustering', 'regulation of apoptotic process', 'regulation of cell cycle', 'regulation of cell migration', 'regulation of dendritic spine morphogenesis', 'regulation of macroautophagy', 'regulation of protein localization to plasma membrane', 'regulation of synaptic plasticity', 'regulation of synaptic transmission, glutamatergic', 'regulation of synaptic vesicle recycling', 'regulation of transcription involved in G1/S transition of mitotic cell cycle', 'response to wounding', 'rhythmic process', 'Schwann cell development', 'sensory perception of pain', 'serine phosphorylation of STAT protein', 'skeletal muscle tissue development', 'synapse assembly', 'synapse pruning', 'synaptic transmission, dopaminergic', 'synaptic transmission, glutamatergic', 'synaptic vesicle endocytosis', 'synaptic vesicle exocytosis', 'synaptic vesicle transport', 'visual learning']['axon guidance', 'axonal fasciculation', 'brain development', 'cerebellum development', 'embryo development ending in birth or egg hatching', 'ephrin receptor signaling pathway', 'G protein-coupled acetylcholine receptor signaling pathway', 'G1 to G0 transition involved in cell differentiation', 'hippocampus development', 'ionotropic glutamate receptor signaling pathway', 'layer formation in cerebral cortex', 'microtubule cytoskeleton organization', 'negative regulation of transcription, DNA-templated', 'neuron cell-cell adhesion', 'neuron differentiation', 'neuron migration', 'neuron projection development', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of MHC class II biosynthetic process', 'positive regulation of microtubule polymerization', 'positive regulation of neuron apoptotic process', 'positive regulation of protein targeting to membrane', 'positive regulation of signaling receptor activity', 'regulation of actin cytoskeleton organization', 'regulation of cyclin-dependent protein serine/threonine kinase activity', 'regulation of dendritic spine morphogenesis', 'regulation of macroautophagy', 'regulation of neuron differentiation', 'regulation of synaptic vesicle cycle', 'rhythmic process', 'serine phosphorylation of STAT protein', 'superior olivary nucleus maturation']
Glycoprotein hormones alpha chain
56
Follitropin subunit beta
50
9.5
82
0.13
Q96QJ4P01225[]['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Hemoglobin subunit alpha
105
Hemoglobin subunit beta
113
9.5
84
0.13
P69905P68871['carbon dioxide transport', 'cellular oxidant detoxification', 'hydrogen peroxide catabolic process', 'nitric oxide transport', 'oxygen transport', 'positive regulation of cell death', 'response to hydrogen peroxide']['carbon dioxide transport', 'cellular oxidant detoxification', 'hydrogen peroxide catabolic process', 'nitric oxide transport', 'oxygen transport', 'platelet aggregation', 'positive regulation of cell death', 'positive regulation of nitric oxide biosynthetic process', 'regulation of blood pressure', 'renal absorption', 'response to hydrogen peroxide']
Importin-4
708
Importin-4
735
9.5
40
0.26
Q8TEX9Q8TEX9['DNA replication-dependent chromatin assembly', 'DNA replication-independent chromatin assembly', 'protein import into nucleus']['DNA replication-dependent chromatin assembly', 'DNA replication-independent chromatin assembly', 'protein import into nucleus']
Ornithine decarboxylase
70
Ornithine decarboxylase
360
9.5
89
0.12
P11926P11926['cell population proliferation', 'kidney development', 'polyamine metabolic process', 'positive regulation of cell population proliferation', 'putrescine biosynthetic process from ornithine', 'regulation of protein catabolic process', 'response to virus']['cell population proliferation', 'kidney development', 'polyamine metabolic process', 'positive regulation of cell population proliferation', 'putrescine biosynthetic process from ornithine', 'regulation of protein catabolic process', 'response to virus']
Bone morphogenetic protein 6
477
Bone morphogenetic protein 6
510
9.5
79
0.13
P22004P22004['BMP signaling pathway', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'cellular response to iron ion', 'cellular response to mechanical stimulus', 'endochondral ossification', 'eye development', 'immune response', 'inflammatory response', 'kidney development', 'male genitalia development', 'multicellular organismal iron ion homeostasis', 'negative regulation of adherens junction organization', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of transcription by RNA polymerase II', 'neuron differentiation', 'osteoblast differentiation', 'positive regulation of aldosterone biosynthetic process', 'positive regulation of aldosterone secretion', 'positive regulation of bone mineralization', 'positive regulation of cell population proliferation', 'positive regulation of chondrocyte differentiation', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of gene expression', 'positive regulation of lipopolysaccharide-mediated signaling pathway', 'positive regulation of neuron differentiation', 'positive regulation of osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vascular permeability', 'response to activity', 'response to glucocorticoid', 'response to magnesium ion', 'response to retinoic acid', 'skeletal system development', 'SMAD protein signal transduction', 'type B pancreatic cell development']['BMP signaling pathway', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'cellular response to iron ion', 'cellular response to mechanical stimulus', 'endochondral ossification', 'eye development', 'immune response', 'inflammatory response', 'kidney development', 'male genitalia development', 'multicellular organismal iron ion homeostasis', 'negative regulation of adherens junction organization', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of transcription by RNA polymerase II', 'neuron differentiation', 'osteoblast differentiation', 'positive regulation of aldosterone biosynthetic process', 'positive regulation of aldosterone secretion', 'positive regulation of bone mineralization', 'positive regulation of cell population proliferation', 'positive regulation of chondrocyte differentiation', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of gene expression', 'positive regulation of lipopolysaccharide-mediated signaling pathway', 'positive regulation of neuron differentiation', 'positive regulation of osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vascular permeability', 'response to activity', 'response to glucocorticoid', 'response to magnesium ion', 'response to retinoic acid', 'skeletal system development', 'SMAD protein signal transduction', 'type B pancreatic cell development']
Serotransferrin
58
Serotransferrin
198
9.5
89
0.12
P02787P02787['actin filament organization', 'antibacterial humoral response', 'cellular iron ion homeostasis', 'cellular response to iron ion', 'ERK1 and ERK2 cascade', 'iron ion homeostasis', 'iron ion transport', 'osteoclast differentiation', 'positive regulation of bone resorption', 'positive regulation of cell motility', 'positive regulation of phosphorylation', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of transcription, DNA-templated', 'regulation of iron ion transport', 'regulation of protein stability', 'retina homeostasis', 'SMAD protein signal transduction']['actin filament organization', 'antibacterial humoral response', 'cellular iron ion homeostasis', 'cellular response to iron ion', 'ERK1 and ERK2 cascade', 'iron ion homeostasis', 'iron ion transport', 'osteoclast differentiation', 'positive regulation of bone resorption', 'positive regulation of cell motility', 'positive regulation of phosphorylation', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of transcription, DNA-templated', 'regulation of iron ion transport', 'regulation of protein stability', 'retina homeostasis', 'SMAD protein signal transduction']
Transforming growth factor beta-1 proprotein
326
Transforming growth factor beta-1 proprotein
355
9.6
79
0.13
P01137P01137['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']
C-C motif chemokine 4
34
C-C motif chemokine 4
35
10.0
75
0.13
P13236P13236['cell adhesion', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'eosinophil chemotaxis', 'establishment or maintenance of cell polarity', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'neutrophil chemotaxis', 'positive regulation of calcium ion transport', 'positive regulation of calcium-mediated signaling', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of natural killer cell chemotaxis', 'response to toxic substance', 'response to virus', 'signal transduction']['cell adhesion', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'eosinophil chemotaxis', 'establishment or maintenance of cell polarity', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'neutrophil chemotaxis', 'positive regulation of calcium ion transport', 'positive regulation of calcium-mediated signaling', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of natural killer cell chemotaxis', 'response to toxic substance', 'response to virus', 'signal transduction']
Actin-related protein 2/3 complex subunit 1B
265
Actin-related protein 2/3 complex subunit 4
21
9.4
85
0.12
Q58CQ2Q148J6['Arp2/3 complex-mediated actin nucleation', 'regulation of actin filament polymerization']['actin filament polymerization', 'Arp2/3 complex-mediated actin nucleation', 'regulation of actin filament polymerization']
Protection of telomeres protein 1
385
Adrenocortical dysplasia protein homolog
228
9.6
56
0.19
Q9NUX5Q96AP0['DNA duplex unwinding', 'establishment of protein localization to telomere', 'negative regulation of telomerase activity', 'negative regulation of telomere maintenance via telomerase', 'positive regulation of DNA helicase activity', 'positive regulation of DNA strand elongation', 'positive regulation of helicase activity', 'positive regulation of telomerase activity', 'positive regulation of telomere maintenance', 'positive regulation of telomere maintenance via telomerase', 'regulation of DNA helicase activity', 'regulation of double-strand break repair via nonhomologous end joining', 'regulation of telomere maintenance via telomerase', 'telomere assembly', 'telomere capping', 'telomere maintenance via telomerase', 'telomeric D-loop disassembly']['embryonic limb morphogenesis', 'establishment of protein localization to telomere', 'intracellular protein transport', 'negative regulation of telomere maintenance via telomerase', 'positive regulation of single-stranded telomeric DNA binding', 'positive regulation of telomerase activity', 'positive regulation of telomere maintenance', 'positive regulation of telomere maintenance via telomerase', 'protection from non-homologous end joining at telomere', 'protein localization to chromosome, telomeric region', 'segmentation', 'skeletal system development', 'telomere assembly', 'telomere capping', 'telomere maintenance', 'telomere maintenance via telomerase', 'urogenital system development']
Dihydropyrimidinase-related protein 2
323
Dihydropyrimidinase-related protein 2
323
9.4
76
0.14
Q16555Q16555['axon guidance', 'brain development', 'cytoskeleton organization', 'endocytosis', 'nervous system development', 'nucleobase-containing compound metabolic process', 'regulation of axon extension', 'regulation of neuron differentiation', 'signal transduction']['axon guidance', 'brain development', 'cytoskeleton organization', 'endocytosis', 'nervous system development', 'nucleobase-containing compound metabolic process', 'regulation of axon extension', 'regulation of neuron differentiation', 'signal transduction']
Gem-associated protein 5
867
Gem-associated protein 5
1045
9.4
90
0.12
Q8TEQ6Q8TEQ6['mRNA splicing, via spliceosome', 'protein-containing complex assembly', 'regulation of translation', 'spliceosomal snRNP assembly', 'translation']['mRNA splicing, via spliceosome', 'protein-containing complex assembly', 'regulation of translation', 'spliceosomal snRNP assembly', 'translation']
Cystatin-8
105
Cystatin-8
139
9.4
69
0.15
P32766P32766[][]
Beta-nerve growth factor
136
Beta-nerve growth factor
231
9.4
100
0.11
P01138P01138['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'extrinsic apoptotic signaling pathway via death domain receptors', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of cell population proliferation', 'negative regulation of neuron apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of collateral sprouting', 'positive regulation of DNA binding', 'positive regulation of gene expression', 'positive regulation of neuron differentiation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of Ras protein signal transduction', 'regulation of neuron differentiation', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'extrinsic apoptotic signaling pathway via death domain receptors', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of cell population proliferation', 'negative regulation of neuron apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of collateral sprouting', 'positive regulation of DNA binding', 'positive regulation of gene expression', 'positive regulation of neuron differentiation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of Ras protein signal transduction', 'regulation of neuron differentiation', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Serine protease 1
220
Serine protease inhibitor Kazal-type 1
39
9.4
82
0.13
P07477P00995['digestion', 'extracellular matrix disassembly', 'proteolysis']['cellular response to peptide hormone stimulus', 'negative regulation of calcium ion import', 'negative regulation of nitric oxide mediated signal transduction', 'negative regulation of peptidyl-tyrosine phosphorylation', 'negative regulation of serine-type endopeptidase activity', 'nitric oxide mediated signal transduction', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of epithelial cell proliferation', 'positive regulation of pancreatic juice secretion', 'positive regulation of peptide hormone secretion', 'regulation of acrosome reaction', 'regulation of store-operated calcium entry', 'response to ethanol', 'response to nutrient levels', 'sperm capacitation']
Fibrinogen beta chain
231
Fibrinogen gamma chain
165
9.4
77
0.14
P02675Q53Y18['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Estrogen receptor
240
Estrogen receptor
227
9.4
61
0.17
P03372P03372['androgen metabolic process', 'antral ovarian follicle growth', 'cellular response to estradiol stimulus', 'cellular response to estrogen stimulus', 'chromatin remodeling', 'epithelial cell development', 'epithelial cell proliferation involved in mammary gland duct elongation', 'fibroblast proliferation', 'intracellular estrogen receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'male gonad development', 'mammary gland alveolus development', 'mammary gland branching involved in pregnancy', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of gene expression', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of miRNA maturation', 'negative regulation of transcription by RNA polymerase II', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of fibroblast proliferation', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of phospholipase C activity', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis', 'prostate epithelial cord elongation', 'protein localization to chromatin', 'regulation of branching involved in prostate gland morphogenesis', 'regulation of epithelial cell apoptotic process', 'regulation of inflammatory response', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to estradiol', 'response to estrogen', 'signal transduction', 'stem cell differentiation', 'transcription by RNA polymerase II', 'uterus development', 'vagina development']['androgen metabolic process', 'antral ovarian follicle growth', 'cellular response to estradiol stimulus', 'cellular response to estrogen stimulus', 'chromatin remodeling', 'epithelial cell development', 'epithelial cell proliferation involved in mammary gland duct elongation', 'fibroblast proliferation', 'intracellular estrogen receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'male gonad development', 'mammary gland alveolus development', 'mammary gland branching involved in pregnancy', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of gene expression', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of miRNA maturation', 'negative regulation of transcription by RNA polymerase II', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of fibroblast proliferation', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of phospholipase C activity', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis', 'prostate epithelial cord elongation', 'protein localization to chromatin', 'regulation of branching involved in prostate gland morphogenesis', 'regulation of epithelial cell apoptotic process', 'regulation of inflammatory response', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to estradiol', 'response to estrogen', 'signal transduction', 'stem cell differentiation', 'transcription by RNA polymerase II', 'uterus development', 'vagina development']
DNA (cytosine-5)-methyltransferase 3A
559
DNA (cytosine-5)-methyltransferase 3A
517
9.4
81
0.13
Q9Y6K1Q9Y6K1['aging', 'C-5 methylation of cytosine', 'cellular response to amino acid stimulus', 'cellular response to bisphenol A', 'cellular response to ethanol', 'cellular response to hypoxia', 'DNA methylation', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'DNA methylation on cytosine', 'DNA methylation-dependent heterochromatin assembly', 'hepatocyte apoptotic process', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron differentiation', 'positive regulation of cell death', 'regulation of gene expression by genomic imprinting', 'response to cocaine', 'response to estradiol', 'response to ionizing radiation', 'response to lead ion', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'spermatogenesis']['aging', 'C-5 methylation of cytosine', 'cellular response to amino acid stimulus', 'cellular response to bisphenol A', 'cellular response to ethanol', 'cellular response to hypoxia', 'DNA methylation', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'DNA methylation on cytosine', 'DNA methylation-dependent heterochromatin assembly', 'hepatocyte apoptotic process', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron differentiation', 'positive regulation of cell death', 'regulation of gene expression by genomic imprinting', 'response to cocaine', 'response to estradiol', 'response to ionizing radiation', 'response to lead ion', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'spermatogenesis']
Beta-secretase 2
344
Beta-secretase 2
393
9.4
77
0.14
Q9Y5Z0Q9Y5Z0['amyloid-beta metabolic process', 'glucose homeostasis', 'membrane protein ectodomain proteolysis', 'negative regulation of amyloid precursor protein biosynthetic process', 'peptide hormone processing', 'proteolysis']['amyloid-beta metabolic process', 'glucose homeostasis', 'membrane protein ectodomain proteolysis', 'negative regulation of amyloid precursor protein biosynthetic process', 'peptide hormone processing', 'proteolysis']
C-C motif chemokine 17
33
C-C motif chemokine 17
34
9.4
78
0.14
Q92583Q92583['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation of myoblast differentiation', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation of myoblast differentiation', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']
Dihydropyrimidinase-related protein 1
323
Dihydropyrimidinase-related protein 1
323
9.6
68
0.15
P97427P97427['axon guidance', 'microtubule cytoskeleton organization', 'negative regulation of actin filament binding', 'negative regulation of neuron projection development', 'semaphorin-plexin signaling pathway']['axon guidance', 'microtubule cytoskeleton organization', 'negative regulation of actin filament binding', 'negative regulation of neuron projection development', 'semaphorin-plexin signaling pathway']
Coagulation factor X
342
Coagulation factor X
164
9.5
71
0.15
P00742P00742['blood coagulation', 'blood coagulation, common pathway', 'positive regulation of cell migration', 'positive regulation of protein kinase B signaling', 'proteolysis', 'zymogen activation']['blood coagulation', 'blood coagulation, common pathway', 'positive regulation of cell migration', 'positive regulation of protein kinase B signaling', 'proteolysis', 'zymogen activation']
Pyruvate kinase PKLR
360
Pyruvate kinase PKLR
74
9.5
74
0.14
P30613P30613['ATP biosynthetic process', 'cellular response to epinephrine stimulus', 'cellular response to insulin stimulus', 'glycolytic process', 'pyruvate biosynthetic process', 'response to ATP', 'response to cAMP', 'response to glucose', 'response to heat', 'response to hypoxia', 'response to lithium ion', 'response to nutrient']['ATP biosynthetic process', 'cellular response to epinephrine stimulus', 'cellular response to insulin stimulus', 'glycolytic process', 'pyruvate biosynthetic process', 'response to ATP', 'response to cAMP', 'response to glucose', 'response to heat', 'response to hypoxia', 'response to lithium ion', 'response to nutrient']
Fibrinogen alpha chain
68
Fibrinogen alpha chain
55
9.4
67
0.16
P02671P02671['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']
Caspase-8
360
Caspase-8
409
9.4
76
0.14
Q14790Q14790['activation of cysteine-type endopeptidase activity', 'activation of cysteine-type endopeptidase activity involved in apoptotic process', 'angiogenesis', 'apoptotic process', 'apoptotic signaling pathway', 'B cell activation', 'cellular response to mechanical stimulus', 'cellular response to organic cyclic compound', 'execution phase of apoptosis', 'extrinsic apoptotic signaling pathway', 'extrinsic apoptotic signaling pathway via death domain receptors', 'heart development', 'macrophage differentiation', 'natural killer cell activation', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of necroptotic process', 'positive regulation of apoptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interleukin-1 beta production', 'positive regulation of macrophage differentiation', 'positive regulation of neuron death', 'positive regulation of proteolysis', 'proteolysis', 'proteolysis involved in protein catabolic process', 'pyroptosis', 'regulation of cytokine production', 'regulation of innate immune response', 'regulation of tumor necrosis factor-mediated signaling pathway', 'response to antibiotic', 'response to cobalt ion', 'response to cold', 'response to estradiol', 'response to ethanol', 'response to lipopolysaccharide', 'response to tumor necrosis factor', 'self proteolysis', 'syncytiotrophoblast cell differentiation involved in labyrinthine layer development', 'T cell activation', 'TRAIL-activated apoptotic signaling pathway']['activation of cysteine-type endopeptidase activity', 'activation of cysteine-type endopeptidase activity involved in apoptotic process', 'angiogenesis', 'apoptotic process', 'apoptotic signaling pathway', 'B cell activation', 'cellular response to mechanical stimulus', 'cellular response to organic cyclic compound', 'execution phase of apoptosis', 'extrinsic apoptotic signaling pathway', 'extrinsic apoptotic signaling pathway via death domain receptors', 'heart development', 'macrophage differentiation', 'natural killer cell activation', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of necroptotic process', 'positive regulation of apoptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interleukin-1 beta production', 'positive regulation of macrophage differentiation', 'positive regulation of neuron death', 'positive regulation of proteolysis', 'proteolysis', 'proteolysis involved in protein catabolic process', 'pyroptosis', 'regulation of cytokine production', 'regulation of innate immune response', 'regulation of tumor necrosis factor-mediated signaling pathway', 'response to antibiotic', 'response to cobalt ion', 'response to cold', 'response to estradiol', 'response to ethanol', 'response to lipopolysaccharide', 'response to tumor necrosis factor', 'self proteolysis', 'syncytiotrophoblast cell differentiation involved in labyrinthine layer development', 'T cell activation', 'TRAIL-activated apoptotic signaling pathway']
Properdin
391
Properdin
127
9.6
65
0.16
P27918P27918['complement activation', 'complement activation, alternative pathway', 'defense response to bacterium', 'immune response', 'positive regulation of immune response', 'positive regulation of opsonization']['complement activation', 'complement activation, alternative pathway', 'defense response to bacterium', 'immune response', 'positive regulation of immune response', 'positive regulation of opsonization']
Proprotein convertase subtilisin/kexin type 9
375
Low-density lipoprotein receptor
329
9.4
67
0.16
Q8NBP7Q59FQ1['apoptotic process', 'cellular response to insulin stimulus', 'cellular response to starvation', 'cholesterol homeostasis', 'cholesterol metabolic process', 'kidney development', 'lipoprotein metabolic process', 'liver development', 'low-density lipoprotein particle receptor catabolic process', 'lysosomal transport', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of low-density lipoprotein particle receptor binding', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of receptor internalization', 'negative regulation of receptor recycling', 'negative regulation of receptor-mediated endocytosis involved in cholesterol transport', 'negative regulation of sodium ion transmembrane transporter activity', 'neurogenesis', 'neuron differentiation', 'phospholipid metabolic process', 'positive regulation of low-density lipoprotein particle receptor catabolic process', 'positive regulation of neuron apoptotic process', 'positive regulation of receptor internalization', 'protein autoprocessing', 'regulation of neuron apoptotic process', 'regulation of signaling receptor activity', 'triglyceride metabolic process']['amyloid-beta clearance', 'amyloid-beta clearance by cellular catabolic process', 'artery morphogenesis', 'cellular response to fatty acid', 'cellular response to low-density lipoprotein particle stimulus', 'cholesterol homeostasis', 'cholesterol import', 'cholesterol metabolic process', 'cholesterol transport', 'endocytosis', 'high-density lipoprotein particle clearance', 'intestinal cholesterol absorption', 'lipid metabolic process', 'lipoprotein catabolic process', 'long-term memory', 'low-density lipoprotein particle clearance', 'negative regulation of amyloid fibril formation', 'negative regulation of astrocyte activation', 'negative regulation of gene expression', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of microglial cell activation', 'negative regulation of protein metabolic process', 'negative regulation of receptor recycling', 'phagocytosis', 'phospholipid transport', 'plasma lipoprotein particle clearance', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of lysosomal protein catabolic process', 'positive regulation of triglyceride biosynthetic process', 'receptor-mediated endocytosis', 'receptor-mediated endocytosis involved in cholesterol transport', 'regulation of cholesterol metabolic process', 'regulation of phosphatidylcholine catabolic process', 'regulation of protein metabolic process', 'response to caloric restriction']
Cobalamin binding intrinsic factor
103
Cobalamin binding intrinsic factor
182
9.6
89
0.12
P27352P27352['cobalamin metabolic process', 'cobalamin transport', 'cobalt ion transport']['cobalamin metabolic process', 'cobalamin transport', 'cobalt ion transport']
Fibrinogen gamma-B chain
43
Fibrinogen gamma-B chain
43
9.4
91
0.12
P12799P12799['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'platelet aggregation', 'protein polymerization']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'platelet aggregation', 'protein polymerization']
Glucocorticoid receptor
473
Glucocorticoid receptor
457
9.6
71
0.15
P04150P04150['adrenal gland development', 'apoptotic process', 'cell cycle', 'cell division', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin organization', 'chromosome segregation', 'glucocorticoid metabolic process', 'intracellular steroid hormone receptor signaling pathway', 'mammary gland duct morphogenesis', 'maternal behavior', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'signal transduction']['adrenal gland development', 'apoptotic process', 'cell cycle', 'cell division', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin organization', 'chromosome segregation', 'glucocorticoid metabolic process', 'intracellular steroid hormone receptor signaling pathway', 'mammary gland duct morphogenesis', 'maternal behavior', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'signal transduction']
DNA dC->dU-editing enzyme APOBEC-3A
64
DNA dC->dU-editing enzyme APOBEC-3A
171
9.5
27
0.39
P31941P31941['cellular response to xenobiotic stimulus', 'clearance of foreign intracellular DNA', 'cytidine to uridine editing', 'defense response to virus', 'DNA cytosine deamination', 'DNA demethylation', 'innate immune response', 'negative regulation of single stranded viral RNA replication via double stranded DNA intermediate', 'negative regulation of transposition', 'negative regulation of viral genome replication']['cellular response to xenobiotic stimulus', 'clearance of foreign intracellular DNA', 'cytidine to uridine editing', 'defense response to virus', 'DNA cytosine deamination', 'DNA demethylation', 'innate immune response', 'negative regulation of single stranded viral RNA replication via double stranded DNA intermediate', 'negative regulation of transposition', 'negative regulation of viral genome replication']
Fibrinogen beta chain
106
Fibrinogen alpha chain
64
9.5
84
0.13
P02675P02671['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']
Hepatocyte growth factor activator
448
Kunitz-type protease inhibitor 1
283
9.5
89
0.12
Q04756O43278['blood coagulation', 'proteolysis', 'zymogen activation']['branching involved in labyrinthine layer morphogenesis', 'cellular response to BMP stimulus', 'epidermis development', 'epithelium development', 'extracellular matrix organization', 'negative regulation of neural precursor cell proliferation', 'neural tube closure', 'placenta blood vessel development', 'positive regulation of glial cell differentiation']
G-protein-signaling modulator 2
161
Nuclear mitotic apparatus protein 1
1907
9.5
52
0.2
P81274Q14980['cell division', 'establishment of mitotic spindle orientation', 'G protein-coupled receptor signaling pathway', 'maintenance of centrosome location', 'mitotic spindle organization', 'positive regulation of protein localization to cell cortex', 'positive regulation of spindle assembly', 'Ran protein signal transduction', 'regulation of mitotic spindle organization']['anastral spindle assembly', 'astral microtubule organization', 'cell division', 'chromosome segregation', 'establishment of mitotic spindle orientation', 'meiotic cell cycle', 'microtubule bundle formation', 'nucleus organization', 'positive regulation of BMP signaling pathway', 'positive regulation of chromosome segregation', 'positive regulation of chromosome separation', 'positive regulation of hair follicle development', 'positive regulation of intracellular transport', 'positive regulation of keratinocyte differentiation', 'positive regulation of microtubule polymerization', 'positive regulation of mitotic spindle elongation', 'positive regulation of protein localization to cell cortex', 'positive regulation of protein localization to spindle pole body', 'positive regulation of spindle assembly', 'regulation of metaphase plate congression', 'regulation of mitotic spindle organization']
Poly [ADP-ribose] polymerase 1
24
Poly [ADP-ribose] polymerase 1
24
9.5
52
0.2
P09874P09874['apoptotic process', 'ATP generation from poly-ADP-D-ribose', 'cellular response to amyloid-beta', 'cellular response to DNA damage stimulus', 'cellular response to insulin stimulus', 'cellular response to oxidative stress', 'cellular response to UV', 'cellular response to zinc ion', 'DNA ADP-ribosylation', 'DNA repair', 'double-strand break repair', 'macrophage differentiation', 'mitochondrial DNA metabolic process', 'mitochondrial DNA repair', 'mitochondrion organization', 'negative regulation of ATP biosynthetic process', 'negative regulation of telomere maintenance via telomere lengthening', 'negative regulation of transcription by RNA polymerase II', 'peptidyl-glutamic acid poly-ADP-ribosylation', 'peptidyl-serine ADP-ribosylation', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of double-strand break repair via homologous recombination', 'positive regulation of intracellular estrogen receptor signaling pathway', 'positive regulation of mitochondrial depolarization', 'positive regulation of myofibroblast differentiation', 'positive regulation of neuron death', 'positive regulation of protein localization to nucleus', 'positive regulation of single strand break repair', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'protein ADP-ribosylation', 'protein auto-ADP-ribosylation', 'protein autoprocessing', 'protein modification process', 'protein poly-ADP-ribosylation', 'regulation of catalytic activity', 'regulation of DNA methylation', 'regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'regulation of protein localization', 'regulation of SMAD protein complex assembly', 'response to aldosterone', 'response to gamma radiation', 'signal transduction involved in regulation of gene expression', 'telomere maintenance', 'transcription by RNA polymerase II', 'transforming growth factor beta receptor signaling pathway']['apoptotic process', 'ATP generation from poly-ADP-D-ribose', 'cellular response to amyloid-beta', 'cellular response to DNA damage stimulus', 'cellular response to insulin stimulus', 'cellular response to oxidative stress', 'cellular response to UV', 'cellular response to zinc ion', 'DNA ADP-ribosylation', 'DNA repair', 'double-strand break repair', 'macrophage differentiation', 'mitochondrial DNA metabolic process', 'mitochondrial DNA repair', 'mitochondrion organization', 'negative regulation of ATP biosynthetic process', 'negative regulation of telomere maintenance via telomere lengthening', 'negative regulation of transcription by RNA polymerase II', 'peptidyl-glutamic acid poly-ADP-ribosylation', 'peptidyl-serine ADP-ribosylation', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of double-strand break repair via homologous recombination', 'positive regulation of intracellular estrogen receptor signaling pathway', 'positive regulation of mitochondrial depolarization', 'positive regulation of myofibroblast differentiation', 'positive regulation of neuron death', 'positive regulation of protein localization to nucleus', 'positive regulation of single strand break repair', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'protein ADP-ribosylation', 'protein auto-ADP-ribosylation', 'protein autoprocessing', 'protein modification process', 'protein poly-ADP-ribosylation', 'regulation of catalytic activity', 'regulation of DNA methylation', 'regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'regulation of protein localization', 'regulation of SMAD protein complex assembly', 'response to aldosterone', 'response to gamma radiation', 'signal transduction involved in regulation of gene expression', 'telomere maintenance', 'transcription by RNA polymerase II', 'transforming growth factor beta receptor signaling pathway']
Placenta growth factor
77
Placenta growth factor
94
9.6
66
0.16
P49763P49763['animal organ regeneration', 'cell differentiation', 'cell-cell signaling', 'cellular response to hormone stimulus', 'female pregnancy', 'induction of positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell proliferation', 'positive regulation of mast cell chemotaxis', 'positive regulation of protein phosphorylation', 'response to hypoxia', 'response to xenobiotic stimulus', 'signal transduction', 'sprouting angiogenesis', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor signaling pathway']['animal organ regeneration', 'cell differentiation', 'cell-cell signaling', 'cellular response to hormone stimulus', 'female pregnancy', 'induction of positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell proliferation', 'positive regulation of mast cell chemotaxis', 'positive regulation of protein phosphorylation', 'response to hypoxia', 'response to xenobiotic stimulus', 'signal transduction', 'sprouting angiogenesis', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor signaling pathway']
Isoaspartyl peptidase/L-asparaginase
115
Isoaspartyl peptidase/L-asparaginase
202
9.6
106
0.1
Q7L266Q7L266['asparagine catabolic process via L-aspartate', 'proteolysis']['asparagine catabolic process via L-aspartate', 'proteolysis']
Asparagine synthetase [glutamine-hydrolyzing]
18
Asparagine synthetase [glutamine-hydrolyzing]
44
9.5
91
0.12
P08243P08243['asparagine biosynthetic process', 'cellular response to glucose starvation', 'glutamine metabolic process', 'L-asparagine biosynthetic process', 'negative regulation of apoptotic process', 'positive regulation of mitotic cell cycle']['asparagine biosynthetic process', 'cellular response to glucose starvation', 'glutamine metabolic process', 'L-asparagine biosynthetic process', 'negative regulation of apoptotic process', 'positive regulation of mitotic cell cycle']
Glial cell line-derived neurotrophic factor
179
Glial cell line-derived neurotrophic factor
178
9.6
67
0.15
Q07731Q07731['branching involved in ureteric bud morphogenesis', 'cell population proliferation', 'cellular response to dexamethasone stimulus', 'commissural neuron axon guidance', 'dorsal spinal cord development', 'embryonic organ development', 'enteric nervous system development', 'male gonad development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'metanephros development', 'midbrain development', 'mRNA stabilization', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of neuron apoptotic process', 'nervous system development', 'neural crest cell migration', 'neuron differentiation', 'neuron projection development', 'organ induction', 'peripheral nervous system development', 'peristalsis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis', 'positive regulation of monooxygenase activity', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of ureteric bud formation', 'postganglionic parasympathetic fiber development', 'postsynaptic membrane organization', 'regulation of dopamine uptake involved in synaptic transmission', 'regulation of gene expression', 'regulation of morphogenesis of a branching structure', 'regulation of semaphorin-plexin signaling pathway', 'regulation of ureteric bud formation', 'response to wounding', 'retina development in camera-type eye', 'sympathetic nervous system development', 'ureteric bud development', 'ureteric bud formation']['branching involved in ureteric bud morphogenesis', 'cell population proliferation', 'cellular response to dexamethasone stimulus', 'commissural neuron axon guidance', 'dorsal spinal cord development', 'embryonic organ development', 'enteric nervous system development', 'male gonad development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'metanephros development', 'midbrain development', 'mRNA stabilization', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of neuron apoptotic process', 'nervous system development', 'neural crest cell migration', 'neuron differentiation', 'neuron projection development', 'organ induction', 'peripheral nervous system development', 'peristalsis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis', 'positive regulation of monooxygenase activity', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of ureteric bud formation', 'postganglionic parasympathetic fiber development', 'postsynaptic membrane organization', 'regulation of dopamine uptake involved in synaptic transmission', 'regulation of gene expression', 'regulation of morphogenesis of a branching structure', 'regulation of semaphorin-plexin signaling pathway', 'regulation of ureteric bud formation', 'response to wounding', 'retina development in camera-type eye', 'sympathetic nervous system development', 'ureteric bud development', 'ureteric bud formation']
Glutamate receptor ionotropic, kainate 2
96
Glutamate receptor ionotropic, kainate 2
96
9.4
78
0.14
P42260P42260['behavioral fear response', 'cellular calcium ion homeostasis', 'chemical synaptic transmission', 'detection of cold stimulus involved in thermoception', 'excitatory postsynaptic potential', 'inhibitory postsynaptic potential', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of synaptic transmission, glutamatergic', 'neuron apoptotic process', 'neuronal action potential', 'positive regulation of neuron apoptotic process', 'positive regulation of synaptic transmission', 'presynaptic modulation of chemical synaptic transmission', 'receptor clustering', 'regulation of JNK cascade', 'regulation of long-term neuronal synaptic plasticity', 'regulation of membrane potential', 'regulation of short-term neuronal synaptic plasticity', 'synaptic transmission, glutamatergic']['behavioral fear response', 'cellular calcium ion homeostasis', 'chemical synaptic transmission', 'detection of cold stimulus involved in thermoception', 'excitatory postsynaptic potential', 'inhibitory postsynaptic potential', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of synaptic transmission, glutamatergic', 'neuron apoptotic process', 'neuronal action potential', 'positive regulation of neuron apoptotic process', 'positive regulation of synaptic transmission', 'presynaptic modulation of chemical synaptic transmission', 'receptor clustering', 'regulation of JNK cascade', 'regulation of long-term neuronal synaptic plasticity', 'regulation of membrane potential', 'regulation of short-term neuronal synaptic plasticity', 'synaptic transmission, glutamatergic']
Complement C4-A
876
Complement C4-A
1583
9.4
70
0.15
P0C0L4P0C0L4['complement activation', 'complement activation, classical pathway', 'inflammatory response', 'innate immune response', 'positive regulation of apoptotic cell clearance', 'positive regulation of immune response', 'positive regulation of opsonization']['complement activation', 'complement activation, classical pathway', 'inflammatory response', 'innate immune response', 'positive regulation of apoptotic cell clearance', 'positive regulation of immune response', 'positive regulation of opsonization']
Androgen receptor
584
Androgen receptor
597
9.4
69
0.15
P15207P15207['activation of prostate induction by androgen receptor signaling pathway', 'androgen receptor signaling pathway', 'animal organ formation', 'cellular response to estrogen stimulus', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to testosterone stimulus', 'copulation', 'epithelial cell differentiation involved in prostate gland development', 'epithelial cell morphogenesis', 'fertilization', 'in utero embryonic development', 'intracellular estrogen receptor signaling pathway', 'intracellular receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lateral sprouting involved in mammary gland duct morphogenesis', 'Leydig cell differentiation', 'male courtship behavior', 'male genitalia morphogenesis', 'male gonad development', 'male sex differentiation', 'male somatic sex determination', 'mammary gland alveolus development', 'morphogenesis of an epithelial fold', 'multicellular organism growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of integrin biosynthetic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell proliferation involved in prostate gland development', 'positive regulation of gene expression', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of integrin biosynthetic process', 'positive regulation of intracellular estrogen receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of penile erection', 'positive regulation of phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase III', 'positive regulation of transcription, DNA-templated', 'prostate gland epithelium morphogenesis', 'prostate gland growth', 'regulation of developmental growth', 'regulation of gene expression', 'regulation of prostatic bud formation', 'regulation of protein localization to plasma membrane', 'regulation of systemic arterial blood pressure', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'reproductive behavior', 'reproductive structure development', 'reproductive system development', 'response to estradiol', 'response to insulin', 'response to testosterone', 'seminiferous tubule development', 'single fertilization', 'skeletal muscle hypertrophy', 'spermatogenesis', 'tertiary branching involved in mammary gland duct morphogenesis']['activation of prostate induction by androgen receptor signaling pathway', 'androgen receptor signaling pathway', 'animal organ formation', 'cellular response to estrogen stimulus', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to testosterone stimulus', 'copulation', 'epithelial cell differentiation involved in prostate gland development', 'epithelial cell morphogenesis', 'fertilization', 'in utero embryonic development', 'intracellular estrogen receptor signaling pathway', 'intracellular receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lateral sprouting involved in mammary gland duct morphogenesis', 'Leydig cell differentiation', 'male courtship behavior', 'male genitalia morphogenesis', 'male gonad development', 'male sex differentiation', 'male somatic sex determination', 'mammary gland alveolus development', 'morphogenesis of an epithelial fold', 'multicellular organism growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of integrin biosynthetic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell proliferation involved in prostate gland development', 'positive regulation of gene expression', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of integrin biosynthetic process', 'positive regulation of intracellular estrogen receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of penile erection', 'positive regulation of phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase III', 'positive regulation of transcription, DNA-templated', 'prostate gland epithelium morphogenesis', 'prostate gland growth', 'regulation of developmental growth', 'regulation of gene expression', 'regulation of prostatic bud formation', 'regulation of protein localization to plasma membrane', 'regulation of systemic arterial blood pressure', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'reproductive behavior', 'reproductive structure development', 'reproductive system development', 'response to estradiol', 'response to insulin', 'response to testosterone', 'seminiferous tubule development', 'single fertilization', 'skeletal muscle hypertrophy', 'spermatogenesis', 'tertiary branching involved in mammary gland duct morphogenesis']
Transforming growth factor beta-1 proprotein
355
Transforming growth factor beta-1 proprotein
293
9.6
78
0.13
P01137P01137['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']
Caspase-9
403
Caspase-9
403
9.5
84
0.12
P55211P55211['activation of cysteine-type endopeptidase activity', 'activation of cysteine-type endopeptidase activity involved in apoptotic process', 'activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c', 'aging', 'apoptotic process', 'cellular response to dexamethasone stimulus', 'cellular response to DNA damage stimulus', 'cellular response to UV', 'epithelial cell apoptotic process', 'fibroblast apoptotic process', 'glial cell apoptotic process', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'kidney development', 'leukocyte apoptotic process', 'neuron apoptotic process', 'platelet formation', 'positive regulation of apoptotic process', 'positive regulation of neuron apoptotic process', 'regulation of response to DNA damage stimulus', 'response to antibiotic', 'response to cobalt ion', 'response to estradiol', 'response to ischemia', 'response to lipopolysaccharide', 'signal transduction in response to DNA damage']['activation of cysteine-type endopeptidase activity', 'activation of cysteine-type endopeptidase activity involved in apoptotic process', 'activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c', 'aging', 'apoptotic process', 'cellular response to dexamethasone stimulus', 'cellular response to DNA damage stimulus', 'cellular response to UV', 'epithelial cell apoptotic process', 'fibroblast apoptotic process', 'glial cell apoptotic process', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'kidney development', 'leukocyte apoptotic process', 'neuron apoptotic process', 'platelet formation', 'positive regulation of apoptotic process', 'positive regulation of neuron apoptotic process', 'regulation of response to DNA damage stimulus', 'response to antibiotic', 'response to cobalt ion', 'response to estradiol', 'response to ischemia', 'response to lipopolysaccharide', 'signal transduction in response to DNA damage']
Platelet-derived growth factor subunit A
123
Platelet-derived growth factor subunit A
140
9.5
67
0.16
P04085P04085['actin cytoskeleton organization', 'angiogenesis', 'animal organ morphogenesis', 'cell activation', 'cell projection assembly', 'cell-cell signaling', 'cellular response to transforming growth factor beta stimulus', 'embryonic lung development', 'hair follicle development', 'inner ear development', 'lung alveolus development', 'male gonad development', 'negative chemotaxis', 'negative regulation of phosphatidylinositol biosynthetic process', 'negative regulation of platelet activation', 'platelet-derived growth factor receptor signaling pathway', 'platelet-derived growth factor receptor-alpha signaling pathway', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mesenchymal cell proliferation', 'positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'regulation of actin cytoskeleton organization', 'regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of smooth muscle cell migration', 'response to estradiol', 'response to hypoxia', 'response to inorganic substance', 'response to retinoic acid', 'response to wounding', 'response to xenobiotic stimulus', 'skin development', 'wound healing']['actin cytoskeleton organization', 'angiogenesis', 'animal organ morphogenesis', 'cell activation', 'cell projection assembly', 'cell-cell signaling', 'cellular response to transforming growth factor beta stimulus', 'embryonic lung development', 'hair follicle development', 'inner ear development', 'lung alveolus development', 'male gonad development', 'negative chemotaxis', 'negative regulation of phosphatidylinositol biosynthetic process', 'negative regulation of platelet activation', 'platelet-derived growth factor receptor signaling pathway', 'platelet-derived growth factor receptor-alpha signaling pathway', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mesenchymal cell proliferation', 'positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'regulation of actin cytoskeleton organization', 'regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of smooth muscle cell migration', 'response to estradiol', 'response to hypoxia', 'response to inorganic substance', 'response to retinoic acid', 'response to wounding', 'response to xenobiotic stimulus', 'skin development', 'wound healing']
Trypsin-3
121
Amyloid-beta precursor protein
324
9.5
85
0.12
P35030P05067['antimicrobial humoral response', 'digestion', 'endothelial cell migration', 'proteolysis', 'zymogen activation']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Protein diaphanous homolog 1
445
Protein diaphanous homolog 1
428
9.5
64
0.16
O08808O08808['actin cytoskeleton organization', 'actin filament polymerization', 'brain development', 'cellular response to histamine', 'cytoskeleton organization', 'neuron projection development', 'positive regulation of cell migration', 'protein localization to microtubule', 'regulation of cell shape', 'regulation of cytoskeleton organization', 'regulation of microtubule-based process', 'regulation of release of sequestered calcium ion into cytosol', 'sensory perception of sound']['actin cytoskeleton organization', 'actin filament polymerization', 'brain development', 'cellular response to histamine', 'cytoskeleton organization', 'neuron projection development', 'positive regulation of cell migration', 'protein localization to microtubule', 'regulation of cell shape', 'regulation of cytoskeleton organization', 'regulation of microtubule-based process', 'regulation of release of sequestered calcium ion into cytosol', 'sensory perception of sound']
Dehydrodolichyl diphosphate synthase complex subunit DHDDS
191
Dehydrodolichyl diphosphate synthase complex subunit NUS1
208
9.6
75
0.14
Q86SQ9Q96E22['dolichyl diphosphate biosynthetic process', 'polyprenol biosynthetic process']['angiogenesis', 'cell differentiation', 'cholesterol homeostasis', 'dolichol biosynthetic process', 'dolichyl diphosphate biosynthetic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of nitric-oxide synthase activity', 'protein glycosylation', 'protein mannosylation', 'regulation of intracellular cholesterol transport', 'vascular endothelial growth factor signaling pathway']
Glutamate receptor 1
75
Glutamate receptor 1
323
9.6
74
0.14
P19490P19490['cellular response to amine stimulus', 'cellular response to amino acid stimulus', 'cellular response to ammonium ion', 'cellular response to dsRNA', 'cellular response to growth factor stimulus', 'cellular response to organic cyclic compound', 'cellular response to peptide hormone stimulus', 'chemical synaptic transmission', 'long-term memory', 'long-term synaptic depression', 'modulation of chemical synaptic transmission', 'neuronal action potential', 'positive regulation of membrane potential', 'positive regulation of synaptic transmission', 'receptor internalization', 'regulation of postsynaptic membrane potential', 'regulation of receptor recycling', 'regulation of synaptic plasticity', 'response to arsenic-containing substance', 'response to cocaine', 'response to electrical stimulus', 'response to estradiol', 'response to fungicide', 'response to lithium ion', 'response to organic cyclic compound', 'response to peptide hormone', 'response to toxic substance', 'response to xenobiotic stimulus', 'spinal cord development', 'synaptic transmission, glutamatergic']['cellular response to amine stimulus', 'cellular response to amino acid stimulus', 'cellular response to ammonium ion', 'cellular response to dsRNA', 'cellular response to growth factor stimulus', 'cellular response to organic cyclic compound', 'cellular response to peptide hormone stimulus', 'chemical synaptic transmission', 'long-term memory', 'long-term synaptic depression', 'modulation of chemical synaptic transmission', 'neuronal action potential', 'positive regulation of membrane potential', 'positive regulation of synaptic transmission', 'receptor internalization', 'regulation of postsynaptic membrane potential', 'regulation of receptor recycling', 'regulation of synaptic plasticity', 'response to arsenic-containing substance', 'response to cocaine', 'response to electrical stimulus', 'response to estradiol', 'response to fungicide', 'response to lithium ion', 'response to organic cyclic compound', 'response to peptide hormone', 'response to toxic substance', 'response to xenobiotic stimulus', 'spinal cord development', 'synaptic transmission, glutamatergic']
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
306
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
306
9.6
95
0.11
P11177P11177['acetyl-CoA biosynthetic process from pyruvate', 'glucose metabolic process', 'mitochondrial acetyl-CoA biosynthetic process from pyruvate', 'tricarboxylic acid cycle']['acetyl-CoA biosynthetic process from pyruvate', 'glucose metabolic process', 'mitochondrial acetyl-CoA biosynthetic process from pyruvate', 'tricarboxylic acid cycle']
Mitogen-activated protein kinase 8
220
Mitogen-activated protein kinase 8
220
9.6
71
0.15
P45983P45983['cellular response to amino acid starvation', 'cellular response to cadmium ion', 'cellular response to lipopolysaccharide', 'cellular response to mechanical stimulus', 'cellular response to oxidative stress', 'cellular response to reactive oxygen species', 'cellular senescence', 'Fc-epsilon receptor signaling pathway', 'intracellular signal transduction', 'JNK cascade', 'JUN phosphorylation', 'negative regulation of apoptotic process', 'negative regulation of protein binding', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of apoptotic process', 'positive regulation of cell killing', 'positive regulation of cyclase activity', 'positive regulation of deacetylase activity', 'positive regulation of gene expression', 'positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway', 'positive regulation of protein metabolic process', 'protein phosphorylation', 'regulation of circadian rhythm', 'regulation of DNA replication origin binding', 'regulation of DNA-binding transcription factor activity', 'regulation of macroautophagy', 'regulation of protein localization', 'response to mechanical stimulus', 'response to oxidative stress', 'response to UV', 'rhythmic process', 'stress-activated MAPK cascade']['cellular response to amino acid starvation', 'cellular response to cadmium ion', 'cellular response to lipopolysaccharide', 'cellular response to mechanical stimulus', 'cellular response to oxidative stress', 'cellular response to reactive oxygen species', 'cellular senescence', 'Fc-epsilon receptor signaling pathway', 'intracellular signal transduction', 'JNK cascade', 'JUN phosphorylation', 'negative regulation of apoptotic process', 'negative regulation of protein binding', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of apoptotic process', 'positive regulation of cell killing', 'positive regulation of cyclase activity', 'positive regulation of deacetylase activity', 'positive regulation of gene expression', 'positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway', 'positive regulation of protein metabolic process', 'protein phosphorylation', 'regulation of circadian rhythm', 'regulation of DNA replication origin binding', 'regulation of DNA-binding transcription factor activity', 'regulation of macroautophagy', 'regulation of protein localization', 'response to mechanical stimulus', 'response to oxidative stress', 'response to UV', 'rhythmic process', 'stress-activated MAPK cascade']
Fibrinogen alpha chain
55
Fibrinogen gamma chain
49
9.5
63
0.17
P02671P02679['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Gremlin-2
120
Gremlin-2
123
9.6
70
0.15
O88273O88273['animal organ morphogenesis', 'cytokine-mediated signaling pathway', 'determination of dorsal identity', 'embryonic body morphogenesis', 'negative regulation of BMP signaling pathway', 'regulation of cytokine activity', 'sequestering of BMP from receptor via BMP binding']['animal organ morphogenesis', 'cytokine-mediated signaling pathway', 'determination of dorsal identity', 'embryonic body morphogenesis', 'negative regulation of BMP signaling pathway', 'regulation of cytokine activity', 'sequestering of BMP from receptor via BMP binding']
Repulsive guidance molecule B
163
Repulsive guidance molecule B
316
9.6
70
0.15
Q6NW40Q6NW40['BMP signaling pathway', 'cell adhesion', 'positive regulation of transcription, DNA-templated', 'signal transduction']['BMP signaling pathway', 'cell adhesion', 'positive regulation of transcription, DNA-templated', 'signal transduction']
NKG2-D type II integral membrane protein
96
NKG2-D type II integral membrane protein
110
9.5
78
0.13
P26718P26718['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of interferon-gamma production', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of nitric oxide biosynthetic process', 'signal transduction', 'stimulatory C-type lectin receptor signaling pathway', 'T cell costimulation']['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of interferon-gamma production', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of nitric oxide biosynthetic process', 'signal transduction', 'stimulatory C-type lectin receptor signaling pathway', 'T cell costimulation']
Phenylethanolamine N-methyltransferase
131
Phenylethanolamine N-methyltransferase
48
9.5
67
0.16
P11086P11086['catecholamine biosynthetic process', 'epinephrine biosynthetic process', 'methylation']['catecholamine biosynthetic process', 'epinephrine biosynthetic process', 'methylation']
Bone morphogenetic protein 2
325
Bone morphogenetic protein 2
360
9.6
82
0.13
P12643P12643['ameloblast differentiation', 'animal organ morphogenesis', 'aortic valve development', 'astrocyte differentiation', 'atrioventricular canal morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'BMP signaling pathway involved in heart development', 'BMP signaling pathway involved in heart induction', 'bone mineralization', 'bone mineralization involved in bone maturation', 'branching involved in ureteric bud morphogenesis', 'cardiac atrium formation', 'cardiac epithelial to mesenchymal transition', 'cardiac jelly development', 'cardiac muscle cell differentiation', 'cardiac muscle tissue morphogenesis', 'cardiocyte differentiation', 'cell fate commitment', 'cell-cell signaling', 'cellular response to BMP stimulus', 'cellular response to organic cyclic compound', 'chondrocyte differentiation', 'corticotropin hormone secreting cell differentiation', 'embryonic heart tube anterior/posterior pattern specification', 'endocardial cushion formation', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'heart development', 'in utero embryonic development', 'inflammatory response', 'inner ear development', 'mesenchymal cell differentiation', 'mesenchymal cell proliferation involved in ureteric bud development', 'mesenchyme development', 'negative regulation of aldosterone biosynthetic process', 'negative regulation of calcium-independent cell-cell adhesion', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cardiac muscle cell differentiation', 'negative regulation of cell cycle', 'negative regulation of cell population proliferation', 'negative regulation of cortisol biosynthetic process', 'negative regulation of gene expression', 'negative regulation of insulin-like growth factor receptor signaling pathway', 'negative regulation of MAP kinase activity', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of steroid biosynthetic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of Wnt signaling pathway involved in heart development', 'Notch signaling pathway', 'odontogenesis of dentin-containing tooth', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'pericardium development', 'positive regulation of apoptotic process', 'positive regulation of astrocyte differentiation', 'positive regulation of bone mineralization', 'positive regulation of cartilage development', 'positive regulation of cell migration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell differentiation', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix constituent secretion', 'positive regulation of fat cell differentiation', 'positive regulation of gene expression', 'positive regulation of MAPK cascade', 'positive regulation of miRNA transcription', 'positive regulation of neuron differentiation', 'positive regulation of odontogenesis', 'positive regulation of ossification', 'positive regulation of osteoblast differentiation', 'positive regulation of osteoblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peroxisome proliferator activated receptor signaling pathway', 'positive regulation of phosphatase activity', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus', 'positive regulation of transcription, DNA-templated', 'positive regulation of Wnt signaling pathway', 'positive regulation of Wnt signaling pathway by BMP signaling pathway', 'protein destabilization', 'protein phosphorylation', 'proteoglycan metabolic process', 'regulation of odontogenesis of dentin-containing tooth', 'regulation of transcription, DNA-templated', 'response to bacterium', 'response to hypoxia', 'skeletal system development', 'SMAD protein signal transduction', 'telencephalon development', 'telencephalon regionalization', 'thyroid-stimulating hormone-secreting cell differentiation', 'transcription by RNA polymerase II', 'Wnt signaling pathway']['ameloblast differentiation', 'animal organ morphogenesis', 'aortic valve development', 'astrocyte differentiation', 'atrioventricular canal morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'BMP signaling pathway involved in heart development', 'BMP signaling pathway involved in heart induction', 'bone mineralization', 'bone mineralization involved in bone maturation', 'branching involved in ureteric bud morphogenesis', 'cardiac atrium formation', 'cardiac epithelial to mesenchymal transition', 'cardiac jelly development', 'cardiac muscle cell differentiation', 'cardiac muscle tissue morphogenesis', 'cardiocyte differentiation', 'cell fate commitment', 'cell-cell signaling', 'cellular response to BMP stimulus', 'cellular response to organic cyclic compound', 'chondrocyte differentiation', 'corticotropin hormone secreting cell differentiation', 'embryonic heart tube anterior/posterior pattern specification', 'endocardial cushion formation', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'heart development', 'in utero embryonic development', 'inflammatory response', 'inner ear development', 'mesenchymal cell differentiation', 'mesenchymal cell proliferation involved in ureteric bud development', 'mesenchyme development', 'negative regulation of aldosterone biosynthetic process', 'negative regulation of calcium-independent cell-cell adhesion', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cardiac muscle cell differentiation', 'negative regulation of cell cycle', 'negative regulation of cell population proliferation', 'negative regulation of cortisol biosynthetic process', 'negative regulation of gene expression', 'negative regulation of insulin-like growth factor receptor signaling pathway', 'negative regulation of MAP kinase activity', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of steroid biosynthetic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of Wnt signaling pathway involved in heart development', 'Notch signaling pathway', 'odontogenesis of dentin-containing tooth', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'pericardium development', 'positive regulation of apoptotic process', 'positive regulation of astrocyte differentiation', 'positive regulation of bone mineralization', 'positive regulation of cartilage development', 'positive regulation of cell migration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell differentiation', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix constituent secretion', 'positive regulation of fat cell differentiation', 'positive regulation of gene expression', 'positive regulation of MAPK cascade', 'positive regulation of miRNA transcription', 'positive regulation of neuron differentiation', 'positive regulation of odontogenesis', 'positive regulation of ossification', 'positive regulation of osteoblast differentiation', 'positive regulation of osteoblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peroxisome proliferator activated receptor signaling pathway', 'positive regulation of phosphatase activity', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus', 'positive regulation of transcription, DNA-templated', 'positive regulation of Wnt signaling pathway', 'positive regulation of Wnt signaling pathway by BMP signaling pathway', 'protein destabilization', 'protein phosphorylation', 'proteoglycan metabolic process', 'regulation of odontogenesis of dentin-containing tooth', 'regulation of transcription, DNA-templated', 'response to bacterium', 'response to hypoxia', 'skeletal system development', 'SMAD protein signal transduction', 'telencephalon development', 'telencephalon regionalization', 'thyroid-stimulating hormone-secreting cell differentiation', 'transcription by RNA polymerase II', 'Wnt signaling pathway']
Serine/threonine-protein kinase Nek7
253
Serine/threonine-protein kinase Nek7
253
9.6
65
0.16
Q8TDX7Q8TDX7['cellular response to potassium ion', 'peptidyl-serine phosphorylation', 'positive regulation of NLRP3 inflammasome complex assembly', 'positive regulation of telomerase activity', 'positive regulation of telomere capping', 'positive regulation of telomere maintenance via telomerase', 'protein phosphorylation', 'regulation of mitotic cell cycle', 'spindle assembly']['cellular response to potassium ion', 'peptidyl-serine phosphorylation', 'positive regulation of NLRP3 inflammasome complex assembly', 'positive regulation of telomerase activity', 'positive regulation of telomere capping', 'positive regulation of telomere maintenance via telomerase', 'protein phosphorylation', 'regulation of mitotic cell cycle', 'spindle assembly']
Fibrinogen alpha chain
64
Fibrinogen beta chain
110
9.6
75
0.14
P02671P02675['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']
Rhodopsin
140
Guanine nucleotide-binding protein G(o) subunit alpha
351
9.6
68
0.15
P02699P09471['absorption of visible light', 'cellular response to light stimulus', 'detection of temperature stimulus involved in thermoception', 'G protein-coupled receptor signaling pathway', 'photoreceptor cell maintenance', 'phototransduction', 'phototransduction, visible light', 'protein phosphorylation', 'response to light stimulus', 'retina development in camera-type eye', 'rhodopsin mediated signaling pathway', 'thermotaxis', 'visual perception']['adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'dopamine receptor signaling pathway', 'muscle contraction']
Resistin-like beta
49
Resistin-like beta
49
9.6
67
0.16
Q99P86Q99P86['response to bacterium']['response to bacterium']
Complement C4-A
876
Complement C4-A
1595
9.6
68
0.15
P0C0L4P0C0L4['complement activation', 'complement activation, classical pathway', 'inflammatory response', 'innate immune response', 'positive regulation of apoptotic cell clearance', 'positive regulation of immune response', 'positive regulation of opsonization']['complement activation', 'complement activation, classical pathway', 'inflammatory response', 'innate immune response', 'positive regulation of apoptotic cell clearance', 'positive regulation of immune response', 'positive regulation of opsonization']
Phospholipase A2, major isoenzyme
99
Phospholipase A2, major isoenzyme
99
9.6
60
0.17
P00592P00592['cellular response to insulin stimulus', 'fatty acid biosynthetic process', 'intracellular signal transduction', 'leukotriene biosynthetic process', 'lipid catabolic process', 'neutrophil chemotaxis', 'neutrophil mediated immunity', 'phosphatidylcholine metabolic process', 'phosphatidylglycerol metabolic process', 'positive regulation of calcium ion transport into cytosol', 'positive regulation of cell population proliferation', 'positive regulation of fibroblast proliferation', 'positive regulation of immune response', 'positive regulation of interleukin-8 production', 'positive regulation of MAP kinase activity', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of podocyte apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of glucose import']['cellular response to insulin stimulus', 'fatty acid biosynthetic process', 'intracellular signal transduction', 'leukotriene biosynthetic process', 'lipid catabolic process', 'neutrophil chemotaxis', 'neutrophil mediated immunity', 'phosphatidylcholine metabolic process', 'phosphatidylglycerol metabolic process', 'positive regulation of calcium ion transport into cytosol', 'positive regulation of cell population proliferation', 'positive regulation of fibroblast proliferation', 'positive regulation of immune response', 'positive regulation of interleukin-8 production', 'positive regulation of MAP kinase activity', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of podocyte apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of glucose import']
Malate dehydrogenase, cytoplasmic
251
Malate dehydrogenase, cytoplasmic
60
9.6
80
0.13
P40925P40925['malate metabolic process', 'NADH metabolic process', 'NADP metabolic process', 'oxaloacetate metabolic process', 'tricarboxylic acid cycle']['malate metabolic process', 'NADH metabolic process', 'NADP metabolic process', 'oxaloacetate metabolic process', 'tricarboxylic acid cycle']
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
305
Succinate dehydrogenase assembly factor 2, mitochondrial
83
9.6
86
0.12
P31040Q9NX18['mitochondrial electron transport, succinate to ubiquinone', 'nervous system development', 'proton motive force-driven mitochondrial ATP synthesis', 'respiratory electron transport chain', 'succinate metabolic process', 'tricarboxylic acid cycle']['mitochondrial electron transport, succinate to ubiquinone', 'mitochondrial respiratory chain complex II assembly', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of epithelial to mesenchymal transition', 'protein dephosphorylation', 'protein-FAD linkage', 'tricarboxylic acid cycle']
Growth/differentiation factor 8
282
Growth/differentiation factor 8
340
9.4
81
0.13
O08689O08689['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
Mitotic spindle assembly checkpoint protein MAD1
662
Mitotic spindle assembly checkpoint protein MAD1
662
9.4
68
0.16
Q9Y6D9Q9Y6D9['attachment of mitotic spindle microtubules to kinetochore', 'cell division', 'cytoplasmic sequestering of protein', 'deactivation of mitotic spindle assembly checkpoint', 'mitotic spindle assembly checkpoint signaling', 'negative regulation of T cell proliferation', 'positive regulation of mitotic cell cycle spindle assembly checkpoint', 'regulation of metaphase plate congression', 'thymus development']['attachment of mitotic spindle microtubules to kinetochore', 'cell division', 'cytoplasmic sequestering of protein', 'deactivation of mitotic spindle assembly checkpoint', 'mitotic spindle assembly checkpoint signaling', 'negative regulation of T cell proliferation', 'positive regulation of mitotic cell cycle spindle assembly checkpoint', 'regulation of metaphase plate congression', 'thymus development']
Lysine-specific histone demethylase 2
227
Lysine-specific histone demethylase 2
227
9.6
70
0.15
Q8NB78Q8NB78['DNA methylation involved in gamete generation', 'histone H3-K4 demethylation', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase II', 'regulation of DNA methylation', 'regulation of gene expression by genomic imprinting']['DNA methylation involved in gamete generation', 'histone H3-K4 demethylation', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase II', 'regulation of DNA methylation', 'regulation of gene expression by genomic imprinting']
Vascular endothelial growth factor A
52
Vascular endothelial growth factor A
77
9.6
77
0.14
Q96NW5Q96NW5['activation of protein kinase activity', 'angiogenesis', 'artery morphogenesis', 'basophil chemotaxis', 'branching involved in blood vessel morphogenesis', 'camera-type eye morphogenesis', 'cardiac muscle cell development', 'cardiac vascular smooth muscle cell development', 'cell maturation', 'cell migration involved in sprouting angiogenesis', 'cellular response to hypoxia', 'cellular response to vascular endothelial growth factor stimulus', 'cellular stress response to acid chemical', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'coronary vein morphogenesis', 'dopaminergic neuron differentiation', 'endothelial cell chemotaxis', 'epithelial cell differentiation', 'eye photoreceptor cell development', 'heart morphogenesis', 'in utero embryonic development', 'induction of positive chemotaxis', 'kidney development', 'lactation', 'lung development', 'lymph vessel morphogenesis', 'macrophage differentiation', 'mammary gland alveolus development', 'mesoderm development', 'monocyte differentiation', 'motor neuron migration', 'negative regulation of adherens junction organization', 'negative regulation of apoptotic process', 'negative regulation of blood-brain barrier permeability', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of establishment of endothelial barrier', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'outflow tract morphogenesis', 'ovarian follicle development', 'positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell migration by vascular endothelial growth factor signaling pathway', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway', 'positive regulation of cold-induced thermogenesis', 'positive regulation of CREB transcription factor activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of histone deacetylase activity', 'positive regulation of leukocyte migration', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of neuroblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of positive chemotaxis', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C signaling', 'positive regulation of protein kinase D signaling', 'positive regulation of protein localization to early endosome', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor internalization', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of trophoblast cell migration', 'positive regulation of vascular permeability', 'post-embryonic camera-type eye development', 'primitive erythrocyte differentiation', 'regulation of cell shape', 'regulation of nitric oxide mediated signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of transcription by RNA polymerase II', 'response to hypoxia', 'sprouting angiogenesis', 'surfactant homeostasis', 'tube formation', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway']['activation of protein kinase activity', 'angiogenesis', 'artery morphogenesis', 'basophil chemotaxis', 'branching involved in blood vessel morphogenesis', 'camera-type eye morphogenesis', 'cardiac muscle cell development', 'cardiac vascular smooth muscle cell development', 'cell maturation', 'cell migration involved in sprouting angiogenesis', 'cellular response to hypoxia', 'cellular response to vascular endothelial growth factor stimulus', 'cellular stress response to acid chemical', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'coronary vein morphogenesis', 'dopaminergic neuron differentiation', 'endothelial cell chemotaxis', 'epithelial cell differentiation', 'eye photoreceptor cell development', 'heart morphogenesis', 'in utero embryonic development', 'induction of positive chemotaxis', 'kidney development', 'lactation', 'lung development', 'lymph vessel morphogenesis', 'macrophage differentiation', 'mammary gland alveolus development', 'mesoderm development', 'monocyte differentiation', 'motor neuron migration', 'negative regulation of adherens junction organization', 'negative regulation of apoptotic process', 'negative regulation of blood-brain barrier permeability', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of establishment of endothelial barrier', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'outflow tract morphogenesis', 'ovarian follicle development', 'positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell migration by vascular endothelial growth factor signaling pathway', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway', 'positive regulation of cold-induced thermogenesis', 'positive regulation of CREB transcription factor activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of histone deacetylase activity', 'positive regulation of leukocyte migration', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of neuroblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of positive chemotaxis', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C signaling', 'positive regulation of protein kinase D signaling', 'positive regulation of protein localization to early endosome', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor internalization', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of trophoblast cell migration', 'positive regulation of vascular permeability', 'post-embryonic camera-type eye development', 'primitive erythrocyte differentiation', 'regulation of cell shape', 'regulation of nitric oxide mediated signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of transcription by RNA polymerase II', 'response to hypoxia', 'sprouting angiogenesis', 'surfactant homeostasis', 'tube formation', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway']
Tyrosyl-DNA phosphodiesterase 2
352
Tyrosyl-DNA phosphodiesterase 2
137
9.6
50
0.21
Q9JJX7Q9JJX7['double-strand break repair', 'neuron development']['double-strand break repair', 'neuron development']
Resistin
55
Resistin
55
9.6
68
0.15
Q99P87Q99P87['fat cell differentiation', 'negative regulation of feeding behavior', 'positive regulation of collagen metabolic process', 'positive regulation of progesterone secretion', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of synaptic transmission', 'response to insulin']['fat cell differentiation', 'negative regulation of feeding behavior', 'positive regulation of collagen metabolic process', 'positive regulation of progesterone secretion', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of synaptic transmission', 'response to insulin']
Oxytocin-neurophysin 1
110
Oxytocin-neurophysin 1
65
9.6
103
0.1
P01175P01175['positive regulation of cold-induced thermogenesis', 'response to estrogen', 'response to external biotic stimulus', 'response to food', 'response to mechanical stimulus']['positive regulation of cold-induced thermogenesis', 'response to estrogen', 'response to external biotic stimulus', 'response to food', 'response to mechanical stimulus']
Acyloxyacyl hydrolase
114
Acyloxyacyl hydrolase
453
9.6
64
0.16
P28039P28039['fatty acid metabolic process', 'lipopolysaccharide catabolic process', 'negative regulation of inflammatory response']['fatty acid metabolic process', 'lipopolysaccharide catabolic process', 'negative regulation of inflammatory response']
Electron transfer flavoprotein subunit alpha, mitochondrial
155
Electron transfer flavoprotein subunit beta
131
9.6
76
0.14
P13804P38117['cellular amino acid catabolic process', 'fatty acid beta-oxidation using acyl-CoA dehydrogenase', 'respiratory electron transport chain']['cellular amino acid catabolic process', 'fatty acid beta-oxidation using acyl-CoA dehydrogenase', 'respiratory electron transport chain']
A disintegrin and metalloproteinase with thrombospondin motifs 4
460
A disintegrin and metalloproteinase with thrombospondin motifs 4
482
9.6
70
0.15
O75173O75173['extracellular matrix disassembly', 'extracellular matrix organization', 'proteolysis', 'skeletal system development']['extracellular matrix disassembly', 'extracellular matrix organization', 'proteolysis', 'skeletal system development']
Methylglutaconyl-CoA hydratase, mitochondrial
311
Methylglutaconyl-CoA hydratase, mitochondrial
311
9.6
88
0.12
Q13825Q13825['fatty acid beta-oxidation', 'leucine catabolic process']['fatty acid beta-oxidation', 'leucine catabolic process']
Platelet-derived growth factor subunit B
141
Platelet-derived growth factor subunit B
124
9.6
62
0.17
P01127P01127['activation of protein kinase activity', 'activation of protein kinase B activity', 'cell chemotaxis', 'cellular response to growth factor stimulus', 'cellular response to mycophenolic acid', 'cellular response to platelet-derived growth factor stimulus', 'embryonic placenta development', 'heart development', 'interleukin-18-mediated signaling pathway', 'metanephric glomerular mesangial cell development', 'monocyte chemotaxis', 'negative regulation of gene expression', 'negative regulation of miRNA transcription', 'negative regulation of phosphatidylinositol biosynthetic process', 'negative regulation of platelet activation', 'negative regulation of protein binding', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular associated smooth muscle cell differentiation', 'paracrine signaling', 'peptidyl-serine phosphorylation', 'peptidyl-tyrosine phosphorylation', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of calcium ion import', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell-substrate adhesion', 'positive regulation of chemotaxis', 'positive regulation of cyclin-dependent protein serine/threonine kinase activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glomerular filtration', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of hyaluronan biosynthetic process', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of metanephric mesenchymal cell migration', 'positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway', 'positive regulation of miRNA transcription', 'positive regulation of mitotic nuclear division', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular associated smooth muscle cell dedifferentiation', 'positive regulation of vascular associated smooth muscle cell migration', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase C signaling', 'protein phosphorylation', 'reactive oxygen species metabolic process', 'response to wounding']['activation of protein kinase activity', 'activation of protein kinase B activity', 'cell chemotaxis', 'cellular response to growth factor stimulus', 'cellular response to mycophenolic acid', 'cellular response to platelet-derived growth factor stimulus', 'embryonic placenta development', 'heart development', 'interleukin-18-mediated signaling pathway', 'metanephric glomerular mesangial cell development', 'monocyte chemotaxis', 'negative regulation of gene expression', 'negative regulation of miRNA transcription', 'negative regulation of phosphatidylinositol biosynthetic process', 'negative regulation of platelet activation', 'negative regulation of protein binding', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular associated smooth muscle cell differentiation', 'paracrine signaling', 'peptidyl-serine phosphorylation', 'peptidyl-tyrosine phosphorylation', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of calcium ion import', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell-substrate adhesion', 'positive regulation of chemotaxis', 'positive regulation of cyclin-dependent protein serine/threonine kinase activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glomerular filtration', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of hyaluronan biosynthetic process', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of metanephric mesenchymal cell migration', 'positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway', 'positive regulation of miRNA transcription', 'positive regulation of mitotic nuclear division', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular associated smooth muscle cell dedifferentiation', 'positive regulation of vascular associated smooth muscle cell migration', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase C signaling', 'protein phosphorylation', 'reactive oxygen species metabolic process', 'response to wounding']
Beta-nerve growth factor
136
Beta-nerve growth factor
231
9.3
85
0.13
P01139P01139['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'adult locomotory behavior', 'axon extension', 'circadian rhythm', 'extrinsic apoptotic signaling pathway in absence of ligand', 'extrinsic apoptotic signaling pathway via death domain receptors', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of type B pancreatic cell apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron projection development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of axon extension', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of collateral sprouting', 'positive regulation of DNA binding', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of neuron differentiation', 'positive regulation of neuron maturation', 'positive regulation of neuron projection development', 'positive regulation of neurotrophin TRK receptor signaling pathway', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein autophosphorylation', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of protein ubiquitination', 'positive regulation of Ras protein signal transduction', 'positive regulation of stem cell proliferation', 'protein phosphorylation', 'regulation of neuron differentiation', 'regulation of neurotransmitter secretion', 'regulation of release of sequestered calcium ion into cytosol', 'sensory perception of pain', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'adult locomotory behavior', 'axon extension', 'circadian rhythm', 'extrinsic apoptotic signaling pathway in absence of ligand', 'extrinsic apoptotic signaling pathway via death domain receptors', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of type B pancreatic cell apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron projection development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of axon extension', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of collateral sprouting', 'positive regulation of DNA binding', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of neuron differentiation', 'positive regulation of neuron maturation', 'positive regulation of neuron projection development', 'positive regulation of neurotrophin TRK receptor signaling pathway', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein autophosphorylation', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of protein ubiquitination', 'positive regulation of Ras protein signal transduction', 'positive regulation of stem cell proliferation', 'protein phosphorylation', 'regulation of neuron differentiation', 'regulation of neurotransmitter secretion', 'regulation of release of sequestered calcium ion into cytosol', 'sensory perception of pain', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Caspase-8
236
Caspase-8
426
9.3
73
0.15
Q14790Q14790['activation of cysteine-type endopeptidase activity', 'activation of cysteine-type endopeptidase activity involved in apoptotic process', 'angiogenesis', 'apoptotic process', 'apoptotic signaling pathway', 'B cell activation', 'cellular response to mechanical stimulus', 'cellular response to organic cyclic compound', 'execution phase of apoptosis', 'extrinsic apoptotic signaling pathway', 'extrinsic apoptotic signaling pathway via death domain receptors', 'heart development', 'macrophage differentiation', 'natural killer cell activation', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of necroptotic process', 'positive regulation of apoptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interleukin-1 beta production', 'positive regulation of macrophage differentiation', 'positive regulation of neuron death', 'positive regulation of proteolysis', 'proteolysis', 'proteolysis involved in protein catabolic process', 'pyroptosis', 'regulation of cytokine production', 'regulation of innate immune response', 'regulation of tumor necrosis factor-mediated signaling pathway', 'response to antibiotic', 'response to cobalt ion', 'response to cold', 'response to estradiol', 'response to ethanol', 'response to lipopolysaccharide', 'response to tumor necrosis factor', 'self proteolysis', 'syncytiotrophoblast cell differentiation involved in labyrinthine layer development', 'T cell activation', 'TRAIL-activated apoptotic signaling pathway']['activation of cysteine-type endopeptidase activity', 'activation of cysteine-type endopeptidase activity involved in apoptotic process', 'angiogenesis', 'apoptotic process', 'apoptotic signaling pathway', 'B cell activation', 'cellular response to mechanical stimulus', 'cellular response to organic cyclic compound', 'execution phase of apoptosis', 'extrinsic apoptotic signaling pathway', 'extrinsic apoptotic signaling pathway via death domain receptors', 'heart development', 'macrophage differentiation', 'natural killer cell activation', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of necroptotic process', 'positive regulation of apoptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interleukin-1 beta production', 'positive regulation of macrophage differentiation', 'positive regulation of neuron death', 'positive regulation of proteolysis', 'proteolysis', 'proteolysis involved in protein catabolic process', 'pyroptosis', 'regulation of cytokine production', 'regulation of innate immune response', 'regulation of tumor necrosis factor-mediated signaling pathway', 'response to antibiotic', 'response to cobalt ion', 'response to cold', 'response to estradiol', 'response to ethanol', 'response to lipopolysaccharide', 'response to tumor necrosis factor', 'self proteolysis', 'syncytiotrophoblast cell differentiation involved in labyrinthine layer development', 'T cell activation', 'TRAIL-activated apoptotic signaling pathway']
Gremlin-2
120
Gremlin-2
101
9.3
73
0.15
O88273O88273['animal organ morphogenesis', 'cytokine-mediated signaling pathway', 'determination of dorsal identity', 'embryonic body morphogenesis', 'negative regulation of BMP signaling pathway', 'regulation of cytokine activity', 'sequestering of BMP from receptor via BMP binding']['animal organ morphogenesis', 'cytokine-mediated signaling pathway', 'determination of dorsal identity', 'embryonic body morphogenesis', 'negative regulation of BMP signaling pathway', 'regulation of cytokine activity', 'sequestering of BMP from receptor via BMP binding']
Oxytocin-neurophysin 1
105
Oxytocin-neurophysin 1
110
9.7
97
0.11
P01175P01175['positive regulation of cold-induced thermogenesis', 'response to estrogen', 'response to external biotic stimulus', 'response to food', 'response to mechanical stimulus']['positive regulation of cold-induced thermogenesis', 'response to estrogen', 'response to external biotic stimulus', 'response to food', 'response to mechanical stimulus']
Baculoviral IAP repeat-containing protein 7
127
Baculoviral IAP repeat-containing protein 7
127
9.3
92
0.12
Q96CA5Q96CA5['lens development in camera-type eye', 'negative regulation of apoptotic process', 'negative regulation of tumor necrosis factor-mediated signaling pathway', 'positive regulation of JNK cascade', 'positive regulation of protein ubiquitination', 'protein ubiquitination', 'regulation of apoptotic process', 'regulation of cell cycle', 'regulation of cell population proliferation', 'regulation of cellular protein metabolic process', 'regulation of natural killer cell apoptotic process']['lens development in camera-type eye', 'negative regulation of apoptotic process', 'negative regulation of tumor necrosis factor-mediated signaling pathway', 'positive regulation of JNK cascade', 'positive regulation of protein ubiquitination', 'protein ubiquitination', 'regulation of apoptotic process', 'regulation of cell cycle', 'regulation of cell population proliferation', 'regulation of cellular protein metabolic process', 'regulation of natural killer cell apoptotic process']
Tyrosyl-DNA phosphodiesterase 2
137
Tyrosyl-DNA phosphodiesterase 2
147
9.3
65
0.17
Q9JJX7Q9JJX7['double-strand break repair', 'neuron development']['double-strand break repair', 'neuron development']
Pyruvate kinase PKM
317
Pyruvate kinase PKM
31
9.3
76
0.14
P14618P14618['canonical glycolysis', 'cellular response to insulin stimulus', 'glycolytic process', 'positive regulation of cytoplasmic translation', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'programmed cell death']['canonical glycolysis', 'cellular response to insulin stimulus', 'glycolytic process', 'positive regulation of cytoplasmic translation', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'programmed cell death']
Group 10 secretory phospholipase A2
100
Group 10 secretory phospholipase A2
125
9.3
70
0.15
O15496O15496['arachidonic acid metabolic process', 'arachidonic acid secretion', 'axon guidance', 'cellular response to leukemia inhibitory factor', 'cholesterol homeostasis', 'defense response to virus', 'erythrocyte maturation', 'fertilization', 'hair follicle morphogenesis', 'intestinal stem cell homeostasis', 'low-density lipoprotein particle remodeling', 'lysophospholipid transport', 'macrophage activation', 'negative regulation of cholesterol efflux', 'negative regulation of cytokine production involved in inflammatory response', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of inflammatory response', 'phosphatidic acid metabolic process', 'phosphatidylcholine catabolic process', 'phosphatidylcholine metabolic process', 'phosphatidylethanolamine metabolic process', 'phosphatidylglycerol metabolic process', 'phosphatidylserine metabolic process', 'phospholipid metabolic process', 'platelet activating factor catabolic process', 'positive regulation of acrosome reaction', 'positive regulation of arachidonic acid secretion', 'positive regulation of lipid storage', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of prostaglandin secretion', 'positive regulation of protein metabolic process', 'production of molecular mediator involved in inflammatory response', 'prostaglandin biosynthetic process', 'regulation of macrophage activation']['arachidonic acid metabolic process', 'arachidonic acid secretion', 'axon guidance', 'cellular response to leukemia inhibitory factor', 'cholesterol homeostasis', 'defense response to virus', 'erythrocyte maturation', 'fertilization', 'hair follicle morphogenesis', 'intestinal stem cell homeostasis', 'low-density lipoprotein particle remodeling', 'lysophospholipid transport', 'macrophage activation', 'negative regulation of cholesterol efflux', 'negative regulation of cytokine production involved in inflammatory response', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of inflammatory response', 'phosphatidic acid metabolic process', 'phosphatidylcholine catabolic process', 'phosphatidylcholine metabolic process', 'phosphatidylethanolamine metabolic process', 'phosphatidylglycerol metabolic process', 'phosphatidylserine metabolic process', 'phospholipid metabolic process', 'platelet activating factor catabolic process', 'positive regulation of acrosome reaction', 'positive regulation of arachidonic acid secretion', 'positive regulation of lipid storage', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of prostaglandin secretion', 'positive regulation of protein metabolic process', 'production of molecular mediator involved in inflammatory response', 'prostaglandin biosynthetic process', 'regulation of macrophage activation']
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
222
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
222
9.3
63
0.17
P50213P50213['carbohydrate metabolic process', 'isocitrate metabolic process', 'tricarboxylic acid cycle']['carbohydrate metabolic process', 'isocitrate metabolic process', 'tricarboxylic acid cycle']
Transcription factor p65
197
NF-kappa-B inhibitor beta
240
9.3
72
0.15
Q04207Q60778['animal organ morphogenesis', 'cellular response to angiotensin', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to hydrogen peroxide', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'cellular response to lipopolysaccharide', 'cellular response to lipoteichoic acid', 'cellular response to nicotine', 'cellular response to peptidoglycan', 'cellular response to tumor necrosis factor', 'cellular response to vascular endothelial growth factor stimulus', 'chromatin organization', 'cytokine-mediated signaling pathway', 'defense response', 'defense response to tumor cell', 'hair follicle development', 'I-kappaB kinase/NF-kappaB signaling', 'inflammatory response', 'innate immune response', 'interleukin-1-mediated signaling pathway', 'liver development', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of miRNA transcription', 'negative regulation of NIK/NF-kappaB signaling', 'negative regulation of protein catabolic process', 'negative regulation of protein sumoylation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuropeptide signaling pathway', 'NIK/NF-kappaB signaling', 'nucleotide-binding oligomerization domain containing 2 signaling pathway', 'positive regulation of amyloid-beta formation', 'positive regulation of cell population proliferation', 'positive regulation of chondrocyte differentiation', 'positive regulation of gene expression', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-8 production', 'positive regulation of leukocyte adhesion to vascular endothelial cell', 'positive regulation of miRNA metabolic process', 'positive regulation of miRNA transcription', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of Schwann cell differentiation', 'positive regulation of T cell receptor signaling pathway', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus', 'positive regulation of transcription, DNA-templated', 'postsynapse to nucleus signaling pathway', 'protein catabolic process', 'regulation of DNA-templated transcription in response to stress', 'regulation of inflammatory response', 'regulation of NIK/NF-kappaB signaling', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to bacterium', 'response to cytokine', 'response to interleukin-1', 'response to muramyl dipeptide', 'response to muscle stretch', 'response to organic substance', 'response to UV-B', 'transcription, DNA-templated', 'tumor necrosis factor-mediated signaling pathway']['cellular response to lipopolysaccharide', 'cytoplasmic sequestering of NF-kappaB', 'inflammatory response', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'signal transduction']
Spindle and kinetochore-associated protein 1
74
Spindle and kinetochore-associated protein 2
79
9.7
64
0.16
Q96BD8Q8WVK7['cell division', 'chromosome segregation', 'mitotic cell cycle', 'regulation of microtubule polymerization or depolymerization']['cell division', 'chromosome segregation', 'mitotic cell cycle', 'regulation of microtubule polymerization or depolymerization']
Caspase-7
290
Caspase-7
290
9.3
88
0.12
P55210P55210['apoptotic process', 'cellular response to staurosporine', 'execution phase of apoptosis', 'extrinsic apoptotic signaling pathway', 'fibroblast apoptotic process', 'heart development', 'inflammatory response', 'intrinsic apoptotic signaling pathway', 'neuron apoptotic process', 'positive regulation of apoptotic process', 'protein processing', 'proteolysis', 'response to UV']['apoptotic process', 'cellular response to staurosporine', 'execution phase of apoptosis', 'extrinsic apoptotic signaling pathway', 'fibroblast apoptotic process', 'heart development', 'inflammatory response', 'intrinsic apoptotic signaling pathway', 'neuron apoptotic process', 'positive regulation of apoptotic process', 'protein processing', 'proteolysis', 'response to UV']
Transforming growth factor beta-1 proprotein
356
Transforming growth factor beta-1 proprotein
355
9.3
82
0.13
P07200P07200['adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains', 'aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'branch elongation involved in mammary gland duct branching', 'bronchiole development', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'cellular calcium ion homeostasis', 'cellular response to ionizing radiation', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'chondrocyte differentiation', 'columnar/cuboidal epithelial cell maturation', 'common-partner SMAD protein phosphorylation', 'embryonic liver development', 'enamel mineralization', 'endoderm development', 'epidermal growth factor receptor signaling pathway', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'face morphogenesis', 'gene expression', 'germ cell migration', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'Langerhans cell differentiation', 'lens fiber cell differentiation', 'lipopolysaccharide-mediated signaling pathway', 'lung alveolus development', 'lymph node development', 'mammary gland branching involved in thelarche', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'muscle cell cellular homeostasis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of epithelial cell proliferation', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of interleukin-17 production', 'negative regulation of macrophage cytokine production', 'negative regulation of myoblast differentiation', 'negative regulation of ossification', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of T cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'Notch signaling pathway', 'oligodendrocyte development', 'ossification involved in bone remodeling', 'osteoclast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'phospholipid homeostasis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of histone acetylation', 'positive regulation of histone deacetylation', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of odontogenesis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor clustering', 'positive regulation of regulatory T cell differentiation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stem cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of actin cytoskeleton reorganization', 'regulation of binding', 'regulation of branching involved in mammary gland duct morphogenesis', 'regulation of cartilage development', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of interleukin-23 production', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of sodium ion transport', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulatory T cell differentiation', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'stem cell proliferation', 'surfactant homeostasis', 'T cell homeostasis', 'T cell proliferation', 'tolerance induction to self antigen', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'ureteric bud development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains', 'aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'branch elongation involved in mammary gland duct branching', 'bronchiole development', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'cellular calcium ion homeostasis', 'cellular response to ionizing radiation', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'chondrocyte differentiation', 'columnar/cuboidal epithelial cell maturation', 'common-partner SMAD protein phosphorylation', 'embryonic liver development', 'enamel mineralization', 'endoderm development', 'epidermal growth factor receptor signaling pathway', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'face morphogenesis', 'gene expression', 'germ cell migration', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'Langerhans cell differentiation', 'lens fiber cell differentiation', 'lipopolysaccharide-mediated signaling pathway', 'lung alveolus development', 'lymph node development', 'mammary gland branching involved in thelarche', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'muscle cell cellular homeostasis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of epithelial cell proliferation', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of interleukin-17 production', 'negative regulation of macrophage cytokine production', 'negative regulation of myoblast differentiation', 'negative regulation of ossification', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of T cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'Notch signaling pathway', 'oligodendrocyte development', 'ossification involved in bone remodeling', 'osteoclast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'phospholipid homeostasis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of histone acetylation', 'positive regulation of histone deacetylation', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of odontogenesis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor clustering', 'positive regulation of regulatory T cell differentiation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stem cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of actin cytoskeleton reorganization', 'regulation of binding', 'regulation of branching involved in mammary gland duct morphogenesis', 'regulation of cartilage development', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of interleukin-23 production', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of sodium ion transport', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulatory T cell differentiation', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'stem cell proliferation', 'surfactant homeostasis', 'T cell homeostasis', 'T cell proliferation', 'tolerance induction to self antigen', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'ureteric bud development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']
Probable ATP-dependent RNA helicase DDX6
385
Probable ATP-dependent RNA helicase DDX6
361
9.3
79
0.14
P26196P26196['miRNA-mediated gene silencing by inhibition of translation', 'negative regulation of neuron differentiation', 'negative regulation of translation', 'neuron differentiation', 'P-body assembly', 'stem cell population maintenance', 'stress granule assembly', 'viral RNA genome packaging']['miRNA-mediated gene silencing by inhibition of translation', 'negative regulation of neuron differentiation', 'negative regulation of translation', 'neuron differentiation', 'P-body assembly', 'stem cell population maintenance', 'stress granule assembly', 'viral RNA genome packaging']
Serine protease 1
48
Pancreatic trypsin inhibitor
49
9.3
98
0.11
P00760P00974['digestion', 'proteolysis']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Transforming growth factor beta-2 proprotein
379
Transforming growth factor beta-2 proprotein
346
9.3
87
0.12
P61812P61812['activation of protein kinase activity', 'ascending aorta morphogenesis', 'atrial septum morphogenesis', 'atrial septum primum morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'cardiac epithelial to mesenchymal transition', 'cardiac muscle cell proliferation', 'cardiac right ventricle morphogenesis', 'cardioblast differentiation', 'cell death', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'collagen fibril organization', 'cranial skeletal system development', 'dopamine biosynthetic process', 'embryo development ending in birth or egg hatching', 'embryonic digestive tract development', 'embryonic limb morphogenesis', 'endocardial cushion fusion', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'extrinsic apoptotic signaling pathway', 'eye development', 'generation of neurons', 'glial cell migration', 'hair follicle development', 'hair follicle morphogenesis', 'heart development', 'heart morphogenesis', 'heart valve morphogenesis', 'hemopoiesis', 'inner ear development', 'kidney development', 'male gonad development', 'membranous septum morphogenesis', 'negative regulation of alkaline phosphatase activity', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'negative regulation of gene expression', 'negative regulation of macrophage cytokine production', 'negative regulation of Ras protein signal transduction', 'neural retina development', 'neural tube closure', 'neuron development', 'neutrophil chemotaxis', 'odontogenesis', 'outflow tract septum morphogenesis', 'pathway-restricted SMAD protein phosphorylation', 'pharyngeal arch artery morphogenesis', 'positive regulation of cardioblast differentiation', 'positive regulation of cell adhesion mediated by integrin', 'positive regulation of cell cycle', 'positive regulation of cell division', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'positive regulation of heart contraction', 'positive regulation of immune response', 'positive regulation of integrin biosynthetic process', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of Notch signaling pathway', 'positive regulation of ossification', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of stress-activated MAPK cascade', 'positive regulation of timing of catagen', 'protein phosphorylation', 'pulmonary valve morphogenesis', 'regulation of apoptotic process involved in outflow tract morphogenesis', 'regulation of cell population proliferation', 'regulation of timing of catagen', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to progesterone', 'response to wounding', 'response to xenobiotic stimulus', 'salivary gland morphogenesis', 'secondary palate development', 'skeletal system development', 'SMAD protein signal transduction', 'somatic stem cell division', 'substantia propria of cornea development', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'uterus development', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis', 'wound healing']['activation of protein kinase activity', 'ascending aorta morphogenesis', 'atrial septum morphogenesis', 'atrial septum primum morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'cardiac epithelial to mesenchymal transition', 'cardiac muscle cell proliferation', 'cardiac right ventricle morphogenesis', 'cardioblast differentiation', 'cell death', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'collagen fibril organization', 'cranial skeletal system development', 'dopamine biosynthetic process', 'embryo development ending in birth or egg hatching', 'embryonic digestive tract development', 'embryonic limb morphogenesis', 'endocardial cushion fusion', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'extrinsic apoptotic signaling pathway', 'eye development', 'generation of neurons', 'glial cell migration', 'hair follicle development', 'hair follicle morphogenesis', 'heart development', 'heart morphogenesis', 'heart valve morphogenesis', 'hemopoiesis', 'inner ear development', 'kidney development', 'male gonad development', 'membranous septum morphogenesis', 'negative regulation of alkaline phosphatase activity', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'negative regulation of gene expression', 'negative regulation of macrophage cytokine production', 'negative regulation of Ras protein signal transduction', 'neural retina development', 'neural tube closure', 'neuron development', 'neutrophil chemotaxis', 'odontogenesis', 'outflow tract septum morphogenesis', 'pathway-restricted SMAD protein phosphorylation', 'pharyngeal arch artery morphogenesis', 'positive regulation of cardioblast differentiation', 'positive regulation of cell adhesion mediated by integrin', 'positive regulation of cell cycle', 'positive regulation of cell division', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'positive regulation of heart contraction', 'positive regulation of immune response', 'positive regulation of integrin biosynthetic process', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of Notch signaling pathway', 'positive regulation of ossification', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of stress-activated MAPK cascade', 'positive regulation of timing of catagen', 'protein phosphorylation', 'pulmonary valve morphogenesis', 'regulation of apoptotic process involved in outflow tract morphogenesis', 'regulation of cell population proliferation', 'regulation of timing of catagen', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to progesterone', 'response to wounding', 'response to xenobiotic stimulus', 'salivary gland morphogenesis', 'secondary palate development', 'skeletal system development', 'SMAD protein signal transduction', 'somatic stem cell division', 'substantia propria of cornea development', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'uterus development', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis', 'wound healing']
Mothers against decapentaplegic homolog 3
307
Zinc finger FYVE domain-containing protein 9
783
9.3
76
0.14
P84022O95405['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'activin receptor signaling pathway', 'adrenal gland development', 'anatomical structure morphogenesis', 'BMP signaling pathway', 'cell differentiation', 'cell-cell junction organization', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'developmental growth', 'embryonic cranial skeleton morphogenesis', 'embryonic foregut morphogenesis', 'embryonic pattern specification', 'endoderm development', 'extrinsic apoptotic signaling pathway', 'heart looping', 'immune response', 'immune system development', 'in utero embryonic development', 'JNK cascade', 'lens fiber cell differentiation', 'liver development', 'mesoderm formation', 'negative regulation of apoptotic process', 'negative regulation of cardiac muscle hypertrophy in response to stress', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cytosolic calcium ion concentration', 'negative regulation of fat cell differentiation', 'negative regulation of inflammatory response', 'negative regulation of lung blood pressure', 'negative regulation of osteoblast differentiation', 'negative regulation of osteoblast proliferation', 'negative regulation of protein catabolic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of wound healing', 'nodal signaling pathway', 'osteoblast development', 'paraxial mesoderm morphogenesis', 'pericardium development', 'positive regulation of alkaline phosphatase activity', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cell migration', 'positive regulation of chondrocyte differentiation', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of extracellular matrix assembly', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of interleukin-1 beta production', 'positive regulation of miRNA transcription', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of positive chemotaxis', 'positive regulation of protein import into nucleus', 'positive regulation of stress fiber assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta3 production', 'primary miRNA processing', 'protein stabilization', 'regulation of binding', 'regulation of epithelial cell proliferation', 'regulation of immune response', 'regulation of miRNA transcription', 'regulation of striated muscle tissue development', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'signal transduction involved in regulation of gene expression', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'somitogenesis', 'T cell activation', 'thyroid gland development', 'transdifferentiation', 'transforming growth factor beta receptor signaling pathway', 'ureteric bud development', 'wound healing']['endocytosis', 'endosomal transport', 'transforming growth factor beta receptor signaling pathway']
Fibrinogen beta chain
231
Fibrinogen gamma chain
165
9.3
76
0.14
P02675P02679['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Resistin-like beta
49
Resistin-like beta
61
9.3
67
0.16
Q99P86Q99P86['response to bacterium']['response to bacterium']
Interleukin-17A
146
Interleukin-17F
107
9.3
86
0.12
Q16552Q96PD4['adaptive immune response', 'apoptotic process', 'cell death', 'cell-cell signaling', 'cellular response to interleukin-1', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'fibroblast activation', 'granulocyte migration', 'immune response', 'inflammatory response', 'innate immune response', 'interleukin-17-mediated signaling pathway', 'intestinal epithelial structure maintenance', 'Notch signaling pathway', 'positive regulation of antimicrobial peptide production', 'positive regulation of bicellular tight junction assembly', 'positive regulation of chemokine (C-X-C motif) ligand 1 production', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-16 production', 'positive regulation of interleukin-23 production', 'positive regulation of interleukin-6 production', 'positive regulation of osteoclast differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production']['adaptive immune response', 'cartilage development', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'inflammatory response', 'innate immune response', 'interleukin-17-mediated signaling pathway', 'negative regulation of angiogenesis', 'positive regulation of antimicrobial peptide production', 'positive regulation of chemokine (C-X-C motif) ligand 1 production', 'positive regulation of cytokine production', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of interleukin-6 production', 'positive regulation of lymphotoxin A production', 'positive regulation of transcription by RNA polymerase II', 'regulation of granulocyte macrophage colony-stimulating factor production', 'regulation of interleukin-2 production', 'regulation of interleukin-6 production', 'regulation of interleukin-8 production', 'regulation of transforming growth factor beta receptor signaling pathway']
Trypsin
117
Trypsin
156
9.7
77
0.13
P00761P00761['digestion', 'proteolysis']['digestion', 'proteolysis']
Resistin
108
Resistin
55
9.3
73
0.15
Q99P87Q99P87['fat cell differentiation', 'negative regulation of feeding behavior', 'positive regulation of collagen metabolic process', 'positive regulation of progesterone secretion', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of synaptic transmission', 'response to insulin']['fat cell differentiation', 'negative regulation of feeding behavior', 'positive regulation of collagen metabolic process', 'positive regulation of progesterone secretion', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of synaptic transmission', 'response to insulin']
Fibrinogen gamma-B chain
47
Fibrinogen gamma-B chain
43
9.3
81
0.13
P12799P12799['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'platelet aggregation', 'protein polymerization']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'platelet aggregation', 'protein polymerization']
DNA repair protein XRCC4
128
DNA repair protein XRCC4
130
9.3
67
0.16
Q13426Q13426['DNA ligation involved in DNA repair', 'double-strand break repair', 'double-strand break repair via nonhomologous end joining', 'immunoglobulin V(D)J recombination', 'positive regulation of ligase activity', 'positive regulation of phosphatidylserine exposure on apoptotic cell surface', 'protein localization to site of double-strand break', 'response to X-ray']['DNA ligation involved in DNA repair', 'double-strand break repair', 'double-strand break repair via nonhomologous end joining', 'immunoglobulin V(D)J recombination', 'positive regulation of ligase activity', 'positive regulation of phosphatidylserine exposure on apoptotic cell surface', 'protein localization to site of double-strand break', 'response to X-ray']
C-C motif chemokine 1
34
C-C motif chemokine 1
33
9.7
72
0.14
P22362P22362['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of inflammatory response', 'positive regulation of interleukin-17 production', 'positive regulation of monocyte chemotaxis', 'signal transduction', 'viral process']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of inflammatory response', 'positive regulation of interleukin-17 production', 'positive regulation of monocyte chemotaxis', 'signal transduction', 'viral process']
Mucin-2
1082
Mucin-2
1088
9.7
90
0.11
Q02817Q02817['maintenance of gastrointestinal epithelium']['maintenance of gastrointestinal epithelium']
Suppressor of tumorigenicity 14 protein
641
Pancreatic trypsin inhibitor
73
9.3
88
0.12
Q9Y5Y6P00974['epithelial cell morphogenesis involved in placental branching', 'keratinocyte differentiation', 'neural tube closure', 'protein catabolic process', 'proteolysis']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Tumor necrosis factor receptor superfamily member 9
120
Tumor necrosis factor receptor superfamily member 9
121
9.3
74
0.15
Q07011Q07011['apoptotic process', 'negative regulation of cell population proliferation', 'regulation of cell population proliferation', 'regulation of immature T cell proliferation in thymus']['apoptotic process', 'negative regulation of cell population proliferation', 'regulation of cell population proliferation', 'regulation of immature T cell proliferation in thymus']
Coagulation factor VII
322
Coagulation factor VII
187
9.7
73
0.14
P08709P08709['activation of blood coagulation via clotting cascade', 'animal organ regeneration', 'blood coagulation', 'blood coagulation, extrinsic pathway', 'blood coagulation, fibrin clot formation', 'blood coagulation, intrinsic pathway', 'circadian rhythm', 'positive regulation of blood coagulation', 'positive regulation of cell migration', 'positive regulation of leukocyte chemotaxis', 'positive regulation of platelet-derived growth factor receptor signaling pathway', 'positive regulation of positive chemotaxis', 'positive regulation of protein kinase B signaling', 'protein processing', 'proteolysis', 'response to 2,3,7,8-tetrachlorodibenzodioxine', 'response to anticoagulant', 'response to astaxanthin', 'response to carbon dioxide', 'response to cholesterol', 'response to estradiol', 'response to estrogen', 'response to genistein', 'response to growth hormone', 'response to hypoxia', 'response to Thyroid stimulating hormone', 'response to thyrotropin-releasing hormone', 'response to thyroxine', 'response to vitamin K', 'response to wounding', 'zymogen activation']['activation of blood coagulation via clotting cascade', 'animal organ regeneration', 'blood coagulation', 'blood coagulation, extrinsic pathway', 'blood coagulation, fibrin clot formation', 'blood coagulation, intrinsic pathway', 'circadian rhythm', 'positive regulation of blood coagulation', 'positive regulation of cell migration', 'positive regulation of leukocyte chemotaxis', 'positive regulation of platelet-derived growth factor receptor signaling pathway', 'positive regulation of positive chemotaxis', 'positive regulation of protein kinase B signaling', 'protein processing', 'proteolysis', 'response to 2,3,7,8-tetrachlorodibenzodioxine', 'response to anticoagulant', 'response to astaxanthin', 'response to carbon dioxide', 'response to cholesterol', 'response to estradiol', 'response to estrogen', 'response to genistein', 'response to growth hormone', 'response to hypoxia', 'response to Thyroid stimulating hormone', 'response to thyrotropin-releasing hormone', 'response to thyroxine', 'response to vitamin K', 'response to wounding', 'zymogen activation']
Elongin-C
112
von Hippel-Lindau disease tumor suppressor
162
9.3
nan
nan
Q15369P40337['protein ubiquitination', 'regulation of transcription by RNA polymerase II', 'transcription initiation from RNA polymerase II promoter', 'ubiquitin-dependent protein catabolic process']['cell morphogenesis', 'negative regulation of apoptotic process', 'negative regulation of cell population proliferation', 'negative regulation of gene expression', 'negative regulation of receptor signaling pathway via JAK-STAT', 'negative regulation of transcription elongation from RNA polymerase II promoter', 'negative regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of cell differentiation', 'positive regulation of transcription, DNA-templated', 'protein stabilization', 'protein ubiquitination', 'proteolysis', 'regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'regulation of transcription, DNA-templated']
Alanine--glyoxylate aminotransferase
293
Alanine--glyoxylate aminotransferase
293
9.7
83
0.12
Q8R128Q8R128['glycine biosynthetic process, by transamination of glyoxylate', 'glyoxylate catabolic process', 'glyoxylate metabolic process', 'L-alanine catabolic process', 'L-cysteine catabolic process', 'L-serine metabolic process', 'Notch signaling pathway', 'oxalic acid secretion', 'pyruvate biosynthetic process', 'response to cAMP', 'response to glucocorticoid']['glycine biosynthetic process, by transamination of glyoxylate', 'glyoxylate catabolic process', 'glyoxylate metabolic process', 'L-alanine catabolic process', 'L-cysteine catabolic process', 'L-serine metabolic process', 'Notch signaling pathway', 'oxalic acid secretion', 'pyruvate biosynthetic process', 'response to cAMP', 'response to glucocorticoid']
Coagulation factor X
341
Coagulation factor X
164
9.3
69
0.16
P00743P00743['blood coagulation', 'proteolysis']['blood coagulation', 'proteolysis']
Fibrinogen gamma chain
49
Fibrinogen gamma chain
45
9.2
81
0.13
P02679P02679['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Protein kinase C delta type
247
Protein kinase C delta type
261
9.2
61
0.18
A0A140UHX0A0A140UHX0['apoptotic process', 'cell cycle', 'protein phosphorylation']['apoptotic process', 'cell cycle', 'protein phosphorylation']
Neuroblastoma suppressor of tumorigenicity 1
63
Neuroblastoma suppressor of tumorigenicity 1
123
9.2
72
0.15
P41271P41271['animal organ morphogenesis', 'determination of dorsal identity', 'negative regulation of BMP signaling pathway', 'negative regulation of monocyte chemotaxis', 'nervous system development', 'neuron projection morphogenesis', 'positive regulation of neuron differentiation', 'sequestering of BMP from receptor via BMP binding', 'sequestering of BMP in extracellular matrix']['animal organ morphogenesis', 'determination of dorsal identity', 'negative regulation of BMP signaling pathway', 'negative regulation of monocyte chemotaxis', 'nervous system development', 'neuron projection morphogenesis', 'positive regulation of neuron differentiation', 'sequestering of BMP from receptor via BMP binding', 'sequestering of BMP in extracellular matrix']
Growth/differentiation factor 11
313
Growth/differentiation factor 11
371
9.2
79
0.14
O95390O95390['amacrine cell differentiation', 'camera-type eye morphogenesis', 'cell population proliferation', 'mesoderm development', 'metanephros development', 'negative regulation of amacrine cell differentiation', 'negative regulation of cell population proliferation', 'nervous system development', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'roof of mouth development', 'skeletal system development', 'SMAD protein signal transduction', 'spinal cord anterior/posterior patterning', 'type B pancreatic cell maturation', 'ureteric bud development']['amacrine cell differentiation', 'camera-type eye morphogenesis', 'cell population proliferation', 'mesoderm development', 'metanephros development', 'negative regulation of amacrine cell differentiation', 'negative regulation of cell population proliferation', 'nervous system development', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'roof of mouth development', 'skeletal system development', 'SMAD protein signal transduction', 'spinal cord anterior/posterior patterning', 'type B pancreatic cell maturation', 'ureteric bud development']
Trypsin-3
105
Pancreatic trypsin inhibitor
49
9.2
95
0.11
P35030P00974['antimicrobial humoral response', 'digestion', 'endothelial cell migration', 'proteolysis', 'zymogen activation']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Cell cycle checkpoint protein RAD1
132
Checkpoint protein HUS1
200
9.7
70
0.15
O60671O60921['cellular response to DNA damage stimulus', 'cellular response to ionizing radiation', 'DNA damage checkpoint signaling', 'DNA repair', 'meiotic recombination checkpoint signaling', 'substantia nigra development']['cellular response to DNA damage stimulus', 'cellular response to ionizing radiation', 'DNA damage checkpoint signaling', 'DNA repair', 'double-strand break repair via homologous recombination', 'embryo development ending in birth or egg hatching', 'meiotic DNA integrity checkpoint signaling', 'mitotic DNA replication checkpoint signaling', 'mitotic intra-S DNA damage checkpoint signaling', 'nucleotide-excision repair', 'protein phosphorylation', 'regulation of protein phosphorylation', 'response to UV', 'telomere maintenance']
Hemoglobin subunit alpha
104
Hemoglobin subunit beta-A/B
112
9.2
86
0.13
P07405P07412['cellular oxidant detoxification', 'hydrogen peroxide catabolic process']['cellular oxidant detoxification', 'hydrogen peroxide catabolic process']
Fibrinogen alpha chain
55
Fibrinogen beta chain
106
9.2
80
0.14
P02671P02675['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']
Parkinson disease protein 7
46
Parkinson disease protein 7
53
9.7
75
0.14
Q99497Q99497['activation of protein kinase B activity', 'adult locomotory behavior', 'autophagy', 'cellular detoxification of aldehyde', 'cellular detoxification of methylglyoxal', 'cellular response to glyoxal', 'cellular response to hydrogen peroxide', 'cellular response to oxidative stress', 'detection of oxidative stress', 'detoxification of copper ion', 'detoxification of mercury ion', 'DNA repair', 'dopamine uptake involved in synaptic transmission', 'glucose homeostasis', 'glutathione deglycation', 'glycolate biosynthetic process', 'glyoxal metabolic process', 'guanine deglycation', 'guanine deglycation, glyoxal removal', 'guanine deglycation, methylglyoxal removal', 'histone modification', 'hydrogen peroxide metabolic process', 'inflammatory response', 'insulin secretion', 'lactate biosynthetic process', 'membrane depolarization', 'membrane hyperpolarization', 'methylglyoxal catabolic process to lactate', 'methylglyoxal metabolic process', 'mitochondrion organization', 'negative regulation of apoptotic process', 'negative regulation of cell death', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'negative regulation of death-inducing signaling complex assembly', 'negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of gene expression', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of hydrogen peroxide-induced neuron death', 'negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of neuron apoptotic process', 'negative regulation of neuron death', 'negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of oxidative stress-induced cell death', 'negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of proteasomal ubiquitin-dependent protein catabolic process', 'negative regulation of protein acetylation', 'negative regulation of protein binding', 'negative regulation of protein export from nucleus', 'negative regulation of protein K48-linked deubiquitination', 'negative regulation of protein kinase activity', 'negative regulation of protein phosphorylation', 'negative regulation of protein sumoylation', 'negative regulation of protein ubiquitination', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of TRAIL-activated apoptotic signaling pathway', 'negative regulation of ubiquitin-protein transferase activity', 'negative regulation of ubiquitin-specific protease activity', 'peptidyl-arginine deglycation', 'peptidyl-cysteine deglycation', 'peptidyl-lysine deglycation', 'positive regulation of acute inflammatory response to antigenic stimulus', 'positive regulation of androgen receptor activity', 'positive regulation of autophagy of mitochondrion', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of dopamine biosynthetic process', 'positive regulation of gene expression', 'positive regulation of interleukin-8 production', 'positive regulation of L-dopa biosynthetic process', 'positive regulation of L-dopa decarboxylase activity', 'positive regulation of mitochondrial electron transport, NADH to ubiquinone', 'positive regulation of NAD(P)H oxidase activity', 'positive regulation of oxidative phosphorylation uncoupler activity', 'positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein-containing complex assembly', 'positive regulation of pyrroline-5-carboxylate reductase activity', 'positive regulation of reactive oxygen species biosynthetic process', 'positive regulation of superoxide dismutase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of tyrosine 3-monooxygenase activity', 'protein deglycation, glyoxal removal', 'protein deglycation, methylglyoxal removal', 'protein deglycosylation', 'protein stabilization', 'proteolysis', 'Ras protein signal transduction', 'regulation of androgen receptor signaling pathway', 'regulation of histone acetylation', 'regulation of histone ubiquitination', 'regulation of inflammatory response', 'regulation of mitochondrial membrane potential', 'regulation of neuron apoptotic process', 'regulation of supramolecular fiber organization', 'response to oxidative stress', 'single fertilization']['activation of protein kinase B activity', 'adult locomotory behavior', 'autophagy', 'cellular detoxification of aldehyde', 'cellular detoxification of methylglyoxal', 'cellular response to glyoxal', 'cellular response to hydrogen peroxide', 'cellular response to oxidative stress', 'detection of oxidative stress', 'detoxification of copper ion', 'detoxification of mercury ion', 'DNA repair', 'dopamine uptake involved in synaptic transmission', 'glucose homeostasis', 'glutathione deglycation', 'glycolate biosynthetic process', 'glyoxal metabolic process', 'guanine deglycation', 'guanine deglycation, glyoxal removal', 'guanine deglycation, methylglyoxal removal', 'histone modification', 'hydrogen peroxide metabolic process', 'inflammatory response', 'insulin secretion', 'lactate biosynthetic process', 'membrane depolarization', 'membrane hyperpolarization', 'methylglyoxal catabolic process to lactate', 'methylglyoxal metabolic process', 'mitochondrion organization', 'negative regulation of apoptotic process', 'negative regulation of cell death', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'negative regulation of death-inducing signaling complex assembly', 'negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of gene expression', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of hydrogen peroxide-induced neuron death', 'negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of neuron apoptotic process', 'negative regulation of neuron death', 'negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of oxidative stress-induced cell death', 'negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of proteasomal ubiquitin-dependent protein catabolic process', 'negative regulation of protein acetylation', 'negative regulation of protein binding', 'negative regulation of protein export from nucleus', 'negative regulation of protein K48-linked deubiquitination', 'negative regulation of protein kinase activity', 'negative regulation of protein phosphorylation', 'negative regulation of protein sumoylation', 'negative regulation of protein ubiquitination', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of TRAIL-activated apoptotic signaling pathway', 'negative regulation of ubiquitin-protein transferase activity', 'negative regulation of ubiquitin-specific protease activity', 'peptidyl-arginine deglycation', 'peptidyl-cysteine deglycation', 'peptidyl-lysine deglycation', 'positive regulation of acute inflammatory response to antigenic stimulus', 'positive regulation of androgen receptor activity', 'positive regulation of autophagy of mitochondrion', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of dopamine biosynthetic process', 'positive regulation of gene expression', 'positive regulation of interleukin-8 production', 'positive regulation of L-dopa biosynthetic process', 'positive regulation of L-dopa decarboxylase activity', 'positive regulation of mitochondrial electron transport, NADH to ubiquinone', 'positive regulation of NAD(P)H oxidase activity', 'positive regulation of oxidative phosphorylation uncoupler activity', 'positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein-containing complex assembly', 'positive regulation of pyrroline-5-carboxylate reductase activity', 'positive regulation of reactive oxygen species biosynthetic process', 'positive regulation of superoxide dismutase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of tyrosine 3-monooxygenase activity', 'protein deglycation, glyoxal removal', 'protein deglycation, methylglyoxal removal', 'protein deglycosylation', 'protein stabilization', 'proteolysis', 'Ras protein signal transduction', 'regulation of androgen receptor signaling pathway', 'regulation of histone acetylation', 'regulation of histone ubiquitination', 'regulation of inflammatory response', 'regulation of mitochondrial membrane potential', 'regulation of neuron apoptotic process', 'regulation of supramolecular fiber organization', 'response to oxidative stress', 'single fertilization']
Pyruvate kinase
352
Pyruvate kinase
66
9.2
79
0.14
Q16716Q16716[][]
Glycoprotein hormones alpha chain
56
Follitropin subunit beta
50
9.2
76
0.14
P01215P01225['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Suppressor of tumorigenicity 14 protein
641
Pancreatic trypsin inhibitor
49
9.2
97
0.11
Q9Y5Y6P00974['epithelial cell morphogenesis involved in placental branching', 'keratinocyte differentiation', 'neural tube closure', 'protein catabolic process', 'proteolysis']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Platelet factor 4 variant
86
Platelet factor 4 variant
86
9.2
68
0.16
P10720P10720['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'inflammatory response', 'neutrophil chemotaxis', 'platelet activation']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'inflammatory response', 'neutrophil chemotaxis', 'platelet activation']
Vascular endothelial growth factor B
47
Vascular endothelial growth factor B
72
9.3
72
0.15
P49765P49765['cardiac muscle contraction', 'coronary vasculature development', 'induction of positive chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of gene expression', 'negative regulation of neuron apoptotic process', 'positive regulation of angiogenesis', 'positive regulation of cell division', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'positive regulation of vascular wound healing', 'protein O-linked glycosylation', 'response to hypoxia', 'sprouting angiogenesis', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor signaling pathway']['cardiac muscle contraction', 'coronary vasculature development', 'induction of positive chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of gene expression', 'negative regulation of neuron apoptotic process', 'positive regulation of angiogenesis', 'positive regulation of cell division', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'positive regulation of vascular wound healing', 'protein O-linked glycosylation', 'response to hypoxia', 'sprouting angiogenesis', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor signaling pathway']
Insulin
90
Insulin
31
9.2
56
0.19
P01317P01317['estradiol secretion', 'feeding behavior', 'glucose import in response to insulin stimulus', 'glucose metabolic process', 'negative regulation of apoptotic process', 'negative regulation of appetite', 'negative regulation of lactation', 'negative regulation of lipid catabolic process', 'positive regulation of blood circulation', 'positive regulation of cell maturation', 'positive regulation of gene expression', 'positive regulation of insulin secretion', 'positive regulation of lactation', 'positive regulation of mammary gland epithelial cell proliferation', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Rho protein signal transduction', 'protein secretion', 'response to butyrate', 'response to food', 'response to glucose', 'response to growth hormone', 'response to heat', 'response to L-arginine', 'response to nutrient levels']['estradiol secretion', 'feeding behavior', 'glucose import in response to insulin stimulus', 'glucose metabolic process', 'negative regulation of apoptotic process', 'negative regulation of appetite', 'negative regulation of lactation', 'negative regulation of lipid catabolic process', 'positive regulation of blood circulation', 'positive regulation of cell maturation', 'positive regulation of gene expression', 'positive regulation of insulin secretion', 'positive regulation of lactation', 'positive regulation of mammary gland epithelial cell proliferation', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Rho protein signal transduction', 'protein secretion', 'response to butyrate', 'response to food', 'response to glucose', 'response to growth hormone', 'response to heat', 'response to L-arginine', 'response to nutrient levels']
Histo-blood group ABO system transferase
80
Histo-blood group ABO system transferase
80
9.2
68
0.16
P16442P16442['carbohydrate metabolic process', 'lipid glycosylation', 'protein glycosylation']['carbohydrate metabolic process', 'lipid glycosylation', 'protein glycosylation']
Tumor necrosis factor ligand superfamily member 13B
245
Tumor necrosis factor ligand superfamily member 13B
245
9.2
100
0.11
Q9Y275Q9Y275['B cell costimulation', 'B cell differentiation', 'B cell homeostasis', 'B cell proliferation', 'germinal center formation', 'positive regulation of B cell proliferation', 'positive regulation of germinal center formation', 'positive regulation of T cell proliferation', 'signal transduction', 'T cell costimulation', 'T cell proliferation', 'tumor necrosis factor-mediated signaling pathway']['B cell costimulation', 'B cell differentiation', 'B cell homeostasis', 'B cell proliferation', 'germinal center formation', 'positive regulation of B cell proliferation', 'positive regulation of germinal center formation', 'positive regulation of T cell proliferation', 'signal transduction', 'T cell costimulation', 'T cell proliferation', 'tumor necrosis factor-mediated signaling pathway']
Protection of telomeres protein 1
464
Adrenocortical dysplasia protein homolog
199
9.7
64
0.16
Q9NUX5Q96AP0['DNA duplex unwinding', 'establishment of protein localization to telomere', 'negative regulation of telomerase activity', 'negative regulation of telomere maintenance via telomerase', 'positive regulation of DNA helicase activity', 'positive regulation of DNA strand elongation', 'positive regulation of helicase activity', 'positive regulation of telomerase activity', 'positive regulation of telomere maintenance', 'positive regulation of telomere maintenance via telomerase', 'regulation of DNA helicase activity', 'regulation of double-strand break repair via nonhomologous end joining', 'regulation of telomere maintenance via telomerase', 'telomere assembly', 'telomere capping', 'telomere maintenance via telomerase', 'telomeric D-loop disassembly']['embryonic limb morphogenesis', 'establishment of protein localization to telomere', 'intracellular protein transport', 'negative regulation of telomere maintenance via telomerase', 'positive regulation of single-stranded telomeric DNA binding', 'positive regulation of telomerase activity', 'positive regulation of telomere maintenance', 'positive regulation of telomere maintenance via telomerase', 'protection from non-homologous end joining at telomere', 'protein localization to chromosome, telomeric region', 'segmentation', 'skeletal system development', 'telomere assembly', 'telomere capping', 'telomere maintenance', 'telomere maintenance via telomerase', 'urogenital system development']
Galectin
17
Galectin
17
9.2
82
0.13
A0A0A7EMW6A0A0A7EMW6[][]
PRKCA-binding protein
44
PRKCA-binding protein
44
9.7
60
0.17
Q9NRD5Q9NRD5['cellular response to decreased oxygen levels', 'cellular response to glucose starvation', 'dendritic spine maintenance', 'dendritic spine organization', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'glial cell development', 'intracellular protein transport', 'long-term synaptic depression', 'monoamine transport', 'negative regulation of Arp2/3 complex-mediated actin nucleation', 'neuronal ion channel clustering', 'positive regulation of receptor internalization', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'receptor clustering', 'regulation of Arp2/3 complex-mediated actin nucleation', 'regulation of insulin secretion', 'retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum']['cellular response to decreased oxygen levels', 'cellular response to glucose starvation', 'dendritic spine maintenance', 'dendritic spine organization', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'glial cell development', 'intracellular protein transport', 'long-term synaptic depression', 'monoamine transport', 'negative regulation of Arp2/3 complex-mediated actin nucleation', 'neuronal ion channel clustering', 'positive regulation of receptor internalization', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'receptor clustering', 'regulation of Arp2/3 complex-mediated actin nucleation', 'regulation of insulin secretion', 'retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum']
Dihydropyrimidinase-related protein 1
323
Dihydropyrimidinase-related protein 1
323
9.2
72
0.15
Q14194Q14194['axon guidance', 'microtubule cytoskeleton organization', 'negative regulation of actin filament binding', 'negative regulation of neuron projection development', 'nervous system development', 'nucleobase-containing compound metabolic process']['axon guidance', 'microtubule cytoskeleton organization', 'negative regulation of actin filament binding', 'negative regulation of neuron projection development', 'nervous system development', 'nucleobase-containing compound metabolic process']
C-C motif chemokine 16
76
C-C motif chemokine 16
37
9.6
75
0.14
O15467O15467['cell communication', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']['cell communication', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']
Piwi-like protein 1
586
Piwi-like protein 1
577
9.6
68
0.15
Q9JMB7Q9JMB7['gene silencing by RNA', 'meiotic cell cycle', 'negative regulation of transposition', 'piRNA metabolic process', 'regulation of translation', 'spermatid development', 'spermatogenesis', 'spermatogenesis, exchange of chromosomal proteins']['gene silencing by RNA', 'meiotic cell cycle', 'negative regulation of transposition', 'piRNA metabolic process', 'regulation of translation', 'spermatid development', 'spermatogenesis', 'spermatogenesis, exchange of chromosomal proteins']
Growth/differentiation factor 8
339
Growth/differentiation factor 8
374
9.5
72
0.15
O14793O14793['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'muscle organ development', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'muscle organ development', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
APOBEC3H
85
APOBEC3H
116
9.3
64
0.17
B7TQM6B7TQM6[][]
Ornithine decarboxylase
360
Ornithine decarboxylase
114
9.3
84
0.13
P11926P11926['cell population proliferation', 'kidney development', 'polyamine metabolic process', 'positive regulation of cell population proliferation', 'putrescine biosynthetic process from ornithine', 'regulation of protein catabolic process', 'response to virus']['cell population proliferation', 'kidney development', 'polyamine metabolic process', 'positive regulation of cell population proliferation', 'putrescine biosynthetic process from ornithine', 'regulation of protein catabolic process', 'response to virus']
Fibrinogen beta chain
223
Fibrinogen gamma chain
165
9.3
70
0.15
P02675P02679['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Cobalamin binding intrinsic factor
103
Cobalamin binding intrinsic factor
143
9.3
84
0.13
P27352P27352['cobalamin metabolic process', 'cobalamin transport', 'cobalt ion transport']['cobalamin metabolic process', 'cobalamin transport', 'cobalt ion transport']
BRCA1-A complex subunit Abraxas 1
296
BRCA1-A complex subunit RAP80
298
9.7
81
0.13
Q8BPZ8Q5U5Q9['attachment of spindle microtubules to kinetochore', 'chromatin organization', 'double-strand break repair', 'histone H2A K63-linked deubiquitination', 'mitotic G2 DNA damage checkpoint signaling', 'mitotic G2/M transition checkpoint', 'mitotic spindle assembly', 'positive regulation of DNA repair', 'protein K63-linked deubiquitination', 'regulation of DNA repair', 'response to ionizing radiation']['chromatin organization', 'double-strand break repair', 'histone H2A K63-linked deubiquitination', 'mitotic G2 DNA damage checkpoint signaling', 'mitotic G2/M transition checkpoint', 'negative regulation of transcription, DNA-templated', 'positive regulation of DNA repair', 'regulation of DNA repair', 'response to ionizing radiation']
Mismatch repair endonuclease PMS2
216
Mismatch repair endonuclease PMS2
202
9.5
92
0.11
P54278P54278['mismatch repair', 'response to xenobiotic stimulus', 'somatic hypermutation of immunoglobulin genes']['mismatch repair', 'response to xenobiotic stimulus', 'somatic hypermutation of immunoglobulin genes']
Estrogen receptor
237
Estrogen receptor
237
9.5
80
0.13
P03372P03372['androgen metabolic process', 'antral ovarian follicle growth', 'cellular response to estradiol stimulus', 'cellular response to estrogen stimulus', 'chromatin remodeling', 'epithelial cell development', 'epithelial cell proliferation involved in mammary gland duct elongation', 'fibroblast proliferation', 'intracellular estrogen receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'male gonad development', 'mammary gland alveolus development', 'mammary gland branching involved in pregnancy', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of gene expression', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of miRNA maturation', 'negative regulation of transcription by RNA polymerase II', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of fibroblast proliferation', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of phospholipase C activity', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis', 'prostate epithelial cord elongation', 'protein localization to chromatin', 'regulation of branching involved in prostate gland morphogenesis', 'regulation of epithelial cell apoptotic process', 'regulation of inflammatory response', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to estradiol', 'response to estrogen', 'signal transduction', 'stem cell differentiation', 'transcription by RNA polymerase II', 'uterus development', 'vagina development']['androgen metabolic process', 'antral ovarian follicle growth', 'cellular response to estradiol stimulus', 'cellular response to estrogen stimulus', 'chromatin remodeling', 'epithelial cell development', 'epithelial cell proliferation involved in mammary gland duct elongation', 'fibroblast proliferation', 'intracellular estrogen receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'male gonad development', 'mammary gland alveolus development', 'mammary gland branching involved in pregnancy', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of gene expression', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of miRNA maturation', 'negative regulation of transcription by RNA polymerase II', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of fibroblast proliferation', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of phospholipase C activity', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis', 'prostate epithelial cord elongation', 'protein localization to chromatin', 'regulation of branching involved in prostate gland morphogenesis', 'regulation of epithelial cell apoptotic process', 'regulation of inflammatory response', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to estradiol', 'response to estrogen', 'signal transduction', 'stem cell differentiation', 'transcription by RNA polymerase II', 'uterus development', 'vagina development']
Metabotropic glutamate receptor 1
601
Metabotropic glutamate receptor 1
601
9.6
49
0.21
Q13255Q13255['cellular response to electrical stimulus', 'chemical synaptic transmission', 'G protein-coupled glutamate receptor signaling pathway', 'G protein-coupled receptor signaling pathway', 'L-glutamate import across plasma membrane', 'locomotory behavior', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of MAPK cascade', 'regulation of sensory perception of pain', 'regulation of synaptic transmission, glutamatergic', 'sensory perception of pain']['cellular response to electrical stimulus', 'chemical synaptic transmission', 'G protein-coupled glutamate receptor signaling pathway', 'G protein-coupled receptor signaling pathway', 'L-glutamate import across plasma membrane', 'locomotory behavior', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of MAPK cascade', 'regulation of sensory perception of pain', 'regulation of synaptic transmission, glutamatergic', 'sensory perception of pain']
Protein timeless homolog
1025
Protein timeless homolog
1025
9.5
81
0.13
Q9UNS1Q9UNS1['branching morphogenesis of an epithelial tube', 'cell cycle phase transition', 'cell division', 'cellular response to bleomycin', 'cellular response to cisplatin', 'cellular response to DNA damage stimulus', 'cellular response to hydroxyurea', 'circadian rhythm', 'detection of abiotic stimulus', 'DNA repair', 'DNA replication checkpoint signaling', 'lung development', 'morphogenesis of an epithelium', 'negative regulation of transcription, DNA-templated', 'positive regulation of double-strand break repair', 'positive regulation of double-strand break repair via homologous recombination', 'regulation of circadian rhythm', 'replication fork arrest', 'replication fork protection']['branching morphogenesis of an epithelial tube', 'cell cycle phase transition', 'cell division', 'cellular response to bleomycin', 'cellular response to cisplatin', 'cellular response to DNA damage stimulus', 'cellular response to hydroxyurea', 'circadian rhythm', 'detection of abiotic stimulus', 'DNA repair', 'DNA replication checkpoint signaling', 'lung development', 'morphogenesis of an epithelium', 'negative regulation of transcription, DNA-templated', 'positive regulation of double-strand break repair', 'positive regulation of double-strand break repair via homologous recombination', 'regulation of circadian rhythm', 'replication fork arrest', 'replication fork protection']
Proproteinase E
196
Proproteinase E
196
9.6
98
0.11
P05805P05805['digestion', 'proteolysis']['digestion', 'proteolysis']
Titin
32733
Titin
32733
9.5
81
0.13
Q8WZ42Q8WZ42['cardiac muscle cell development', 'cardiac muscle contraction', 'cardiac muscle hypertrophy', 'cardiac muscle tissue morphogenesis', 'cardiac myofibril assembly', 'detection of muscle stretch', 'mitotic chromosome condensation', 'muscle contraction', 'positive regulation of gene expression', 'positive regulation of protein secretion', 'protein kinase A signaling', 'regulation of catalytic activity', 'regulation of protein kinase activity', 'response to calcium ion', 'sarcomere organization', 'sarcomerogenesis', 'skeletal muscle myosin thick filament assembly', 'skeletal muscle thin filament assembly', 'striated muscle contraction']['cardiac muscle cell development', 'cardiac muscle contraction', 'cardiac muscle hypertrophy', 'cardiac muscle tissue morphogenesis', 'cardiac myofibril assembly', 'detection of muscle stretch', 'mitotic chromosome condensation', 'muscle contraction', 'positive regulation of gene expression', 'positive regulation of protein secretion', 'protein kinase A signaling', 'regulation of catalytic activity', 'regulation of protein kinase activity', 'response to calcium ion', 'sarcomere organization', 'sarcomerogenesis', 'skeletal muscle myosin thick filament assembly', 'skeletal muscle thin filament assembly', 'striated muscle contraction']
Isoform L-VEGF206 of Vascular endothelial growth factor A
257
Isoform L-VEGF206 of Vascular endothelial growth factor A
232
9.6
70
0.15
P15692-14P15692-14[][]
Paternally-expressed gene 3 protein
114
Paternally-expressed gene 3 protein
71
9.6
67
0.16
Q9GZU2Q9GZU2['apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase II', 'regulation of gene expression', 'regulation of transcription by RNA polymerase II']['apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase II', 'regulation of gene expression', 'regulation of transcription by RNA polymerase II']
Glucocorticoid receptor
476
Glucocorticoid receptor
463
9.7
68
0.15
P79269P79269['cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'chromatin organization', 'positive regulation of transcription by RNA polymerase II']['cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'chromatin organization', 'positive regulation of transcription by RNA polymerase II']
BRISC and BRCA1-A complex member 2
307
BRISC and BRCA1-A complex member 1
298
9.6
74
0.14
Q8K3W0Q3UI43['apoptotic process', 'cell division', 'cellular response to DNA damage stimulus', 'cellular response to ionizing radiation', 'chromatin organization', 'double-strand break repair', 'histone H2A K63-linked deubiquitination', 'histone H2A monoubiquitination', 'mitotic G2 DNA damage checkpoint signaling', 'mitotic G2/M transition checkpoint', 'negative regulation of apoptotic process', 'positive regulation of DNA repair', 'protein autoubiquitination', 'regulation of DNA damage checkpoint', 'regulation of DNA repair', 'response to ionizing radiation']['cell division', 'chromatin organization', 'double-strand break repair', 'hematopoietic stem cell proliferation', 'histone H2A K63-linked deubiquitination', 'mitotic G2 DNA damage checkpoint signaling', 'mitotic G2/M transition checkpoint', 'positive regulation of DNA repair', 'protein K63-linked deubiquitination', 'regulation of DNA repair', 'response to ionizing radiation']
Fatty acid-binding protein 5
47
Fatty acid-binding protein 5
87
9.5
60
0.18
Q01469Q01469['epidermis development', 'fatty acid transport', 'glucose homeostasis', 'glucose metabolic process', 'lipid metabolic process', 'lipid transport across blood-brain barrier', 'long-chain fatty acid transport', 'negative regulation of glucose transmembrane transport', 'phosphatidylcholine biosynthetic process', 'positive regulation of cold-induced thermogenesis', 'positive regulation of peroxisome proliferator activated receptor signaling pathway', 'regulation of prostaglandin biosynthetic process', 'regulation of retrograde trans-synaptic signaling by endocanabinoid', 'regulation of sensory perception of pain']['epidermis development', 'fatty acid transport', 'glucose homeostasis', 'glucose metabolic process', 'lipid metabolic process', 'lipid transport across blood-brain barrier', 'long-chain fatty acid transport', 'negative regulation of glucose transmembrane transport', 'phosphatidylcholine biosynthetic process', 'positive regulation of cold-induced thermogenesis', 'positive regulation of peroxisome proliferator activated receptor signaling pathway', 'regulation of prostaglandin biosynthetic process', 'regulation of retrograde trans-synaptic signaling by endocanabinoid', 'regulation of sensory perception of pain']
Calcium/calmodulin-dependent protein kinase type 1G
214
Calcium/calmodulin-dependent protein kinase type 1G
180
9.5
80
0.13
Q96NX5Q96NX5['peptidyl-serine phosphorylation']['peptidyl-serine phosphorylation']
Ferritin
127
Ferritin
127
9.6
65
0.16
Q9CPX4Q9CPX4['cellular iron ion homeostasis', 'iron ion transport']['cellular iron ion homeostasis', 'iron ion transport']
Cryptochrome-2
381
F-box/LRR-repeat protein 3
340
9.5
82
0.13
Q9R194Q9UKT7['circadian regulation of gene expression', 'circadian rhythm', 'entrainment of circadian clock by photoperiod', 'glucose homeostasis', 'lipid storage', 'negative regulation of circadian rhythm', 'negative regulation of glucocorticoid receptor signaling pathway', 'negative regulation of glucocorticoid secretion', 'negative regulation of phosphoprotein phosphatase activity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'protein import into nucleus', 'regulation of circadian rhythm', 'regulation of sodium-dependent phosphate transport', 'response to activity', 'response to insulin', 'response to light stimulus']['entrainment of circadian clock by photoperiod', 'G2/M transition of mitotic cell cycle', 'protein destabilization', 'protein ubiquitination', 'regulation of cell cycle', 'regulation of circadian rhythm', 'rhythmic process', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process']
Ornithine decarboxylase
164
Ornithine decarboxylase
360
9.5
75
0.14
P11926P11926['cell population proliferation', 'kidney development', 'polyamine metabolic process', 'positive regulation of cell population proliferation', 'putrescine biosynthetic process from ornithine', 'regulation of protein catabolic process', 'response to virus']['cell population proliferation', 'kidney development', 'polyamine metabolic process', 'positive regulation of cell population proliferation', 'putrescine biosynthetic process from ornithine', 'regulation of protein catabolic process', 'response to virus']
Seminal ribonuclease
58
Seminal ribonuclease
121
9.5
62
0.17
P00669P00669['defense response to Gram-positive bacterium', 'RNA phosphodiester bond hydrolysis']['defense response to Gram-positive bacterium', 'RNA phosphodiester bond hydrolysis']
Potassium voltage-gated channel subfamily D member 3
93
Potassium voltage-gated channel subfamily D member 3
110
9.5
76
0.14
Q9UK17Q9UK17['membrane repolarization', 'membrane repolarization during cardiac muscle cell action potential', 'membrane repolarization during ventricular cardiac muscle cell action potential', 'potassium ion export across plasma membrane', 'potassium ion transmembrane transport', 'potassium ion transport', 'protein homooligomerization', 'regulation of heart rate by cardiac conduction', 'regulation of ion transmembrane transport', 'ventricular cardiac muscle cell membrane repolarization']['membrane repolarization', 'membrane repolarization during cardiac muscle cell action potential', 'membrane repolarization during ventricular cardiac muscle cell action potential', 'potassium ion export across plasma membrane', 'potassium ion transmembrane transport', 'potassium ion transport', 'protein homooligomerization', 'regulation of heart rate by cardiac conduction', 'regulation of ion transmembrane transport', 'ventricular cardiac muscle cell membrane repolarization']
Kelch-like ECH-associated protein 1
518
Kelch-like ECH-associated protein 1
489
9.3
74
0.15
Q14145Q14145['cellular response to interleukin-4', 'cellular response to oxidative stress', 'cytoplasmic sequestering of transcription factor', 'in utero embryonic development', 'negative regulation of DNA-binding transcription factor activity', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'protein ubiquitination', 'regulation of autophagy', 'regulation of epidermal cell differentiation', 'ubiquitin-dependent protein catabolic process']['cellular response to interleukin-4', 'cellular response to oxidative stress', 'cytoplasmic sequestering of transcription factor', 'in utero embryonic development', 'negative regulation of DNA-binding transcription factor activity', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'protein ubiquitination', 'regulation of autophagy', 'regulation of epidermal cell differentiation', 'ubiquitin-dependent protein catabolic process']
Ephrin type-A receptor 4
108
Ephrin type-A receptor 4
118
9.3
82
0.13
P54764P54764['adherens junction organization', 'adult walking behavior', 'axon guidance', 'cell adhesion', 'cellular response to amyloid-beta', 'cochlea development', 'corticospinal tract morphogenesis', 'ephrin receptor signaling pathway', 'fasciculation of motor neuron axon', 'fasciculation of sensory neuron axon', 'glial cell migration', 'motor neuron axon guidance', 'negative regulation of axon regeneration', 'negative regulation of cell adhesion', 'negative regulation of cell migration', 'negative regulation of cellular response to hypoxia', 'negative regulation of epithelial to mesenchymal transition', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of long-term synaptic potentiation', 'negative regulation of neuron projection development', 'negative regulation of proteolysis involved in protein catabolic process', 'nephric duct morphogenesis', 'neuron projection fasciculation', 'neuron projection guidance', 'peptidyl-tyrosine phosphorylation', 'positive regulation of amyloid-beta formation', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of dendrite morphogenesis', 'positive regulation of JUN kinase activity', 'positive regulation of kinase activity', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of Rho guanyl-nucleotide exchange factor activity', 'protein autophosphorylation', 'protein stabilization', 'regulation of astrocyte differentiation', 'regulation of axonogenesis', 'regulation of dendritic spine morphogenesis', 'regulation of GTPase activity', 'regulation of modification of synaptic structure', 'synapse pruning', 'transmembrane receptor protein tyrosine kinase signaling pathway']['adherens junction organization', 'adult walking behavior', 'axon guidance', 'cell adhesion', 'cellular response to amyloid-beta', 'cochlea development', 'corticospinal tract morphogenesis', 'ephrin receptor signaling pathway', 'fasciculation of motor neuron axon', 'fasciculation of sensory neuron axon', 'glial cell migration', 'motor neuron axon guidance', 'negative regulation of axon regeneration', 'negative regulation of cell adhesion', 'negative regulation of cell migration', 'negative regulation of cellular response to hypoxia', 'negative regulation of epithelial to mesenchymal transition', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of long-term synaptic potentiation', 'negative regulation of neuron projection development', 'negative regulation of proteolysis involved in protein catabolic process', 'nephric duct morphogenesis', 'neuron projection fasciculation', 'neuron projection guidance', 'peptidyl-tyrosine phosphorylation', 'positive regulation of amyloid-beta formation', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of dendrite morphogenesis', 'positive regulation of JUN kinase activity', 'positive regulation of kinase activity', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of Rho guanyl-nucleotide exchange factor activity', 'protein autophosphorylation', 'protein stabilization', 'regulation of astrocyte differentiation', 'regulation of axonogenesis', 'regulation of dendritic spine morphogenesis', 'regulation of GTPase activity', 'regulation of modification of synaptic structure', 'synapse pruning', 'transmembrane receptor protein tyrosine kinase signaling pathway']
CDC42BPB protein
41
CDC42BPB protein
41
9.7
71
0.15
Q86XZ8Q86XZ8['actin cytoskeleton organization', 'cell migration', 'protein phosphorylation']['actin cytoskeleton organization', 'cell migration', 'protein phosphorylation']
S-adenosylmethionine decarboxylase proenzyme
49
S-adenosylmethionine decarboxylase proenzyme
82
9.3
66
0.16
P17707P17707['polyamine metabolic process', 'S-adenosylmethioninamine biosynthetic process', 'S-adenosylmethionine metabolic process', 'spermidine biosynthetic process', 'spermine biosynthetic process']['polyamine metabolic process', 'S-adenosylmethioninamine biosynthetic process', 'S-adenosylmethionine metabolic process', 'spermidine biosynthetic process', 'spermine biosynthetic process']
Fibrinogen alpha chain
184
Fibrinogen gamma chain
165
9.3
70
0.15
P02671P02679['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Fibrinogen gamma-B chain
47
Fibrinogen beta chain
72
9.3
72
0.15
P12799P02676['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'platelet aggregation', 'protein polymerization']['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'innate immune response', 'platelet aggregation', 'protein polymerization']
Glycoprotein hormones alpha chain
111
Follitropin subunit beta
50
9.3
78
0.14
Q96QJ4P01225[]['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Recombining binding protein suppressor of hairless
397
Mastermind-like protein 1
37
9.3
77
0.14
Q06330Q92585['angiogenesis', 'aortic valve development', 'arterial endothelial cell fate commitment', 'atrioventricular canal development', 'auditory receptor cell fate commitment', 'B cell differentiation', 'blood vessel endothelial cell fate specification', 'blood vessel lumenization', 'blood vessel remodeling', 'cardiac left ventricle morphogenesis', 'cardiac muscle cell myoblast differentiation', 'club cell differentiation', 'defense response to bacterium', 'dorsal aorta morphogenesis', 'endocardium morphogenesis', 'epidermal cell fate specification', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'epithelial to mesenchymal transition involved in endocardial cushion formation', 'hair follicle maturation', 'humoral immune response', 'inflammatory response to antigenic stimulus', 'keratinocyte differentiation', 'labyrinthine layer blood vessel development', 'myeloid dendritic cell differentiation', 'negative regulation of cell differentiation', 'negative regulation of cold-induced thermogenesis', 'negative regulation of ossification', 'negative regulation of stem cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'Notch signaling involved in heart development', 'Notch signaling pathway', 'outflow tract morphogenesis', 'pituitary gland development', 'positive regulation of BMP signaling pathway', 'positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cell proliferation involved in heart morphogenesis', 'positive regulation of ephrin receptor signaling pathway', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERBB signaling pathway', 'positive regulation of gene expression', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription of Notch receptor target', 'pulmonary valve development', 'regulation of reproductive process', 'regulation of timing of cell differentiation', 'regulation of transcription by RNA polymerase II', 'sebaceous gland development', 'secondary heart field specification', 'somatic stem cell population maintenance', 'somitogenesis', 'stem cell proliferation', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis']['atrioventricular node cell development', 'atrioventricular node development', 'myoblast differentiation', 'Notch signaling pathway', 'positive regulation of myotube differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription of Notch receptor target', 'protein phosphorylation']
Caspase-6
277
Caspase-6
277
9.3
92
0.12
P55212P55212['activation of cysteine-type endopeptidase activity', 'activation of innate immune response', 'apoptotic process', 'cellular response to staurosporine', 'epithelial cell differentiation', 'hepatocyte apoptotic process', 'intrinsic apoptotic signaling pathway by p53 class mediator', 'positive regulation of apoptotic process', 'positive regulation of necroptotic process', 'protein autoprocessing', 'proteolysis', 'pyroptosis', 'regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway']['activation of cysteine-type endopeptidase activity', 'activation of innate immune response', 'apoptotic process', 'cellular response to staurosporine', 'epithelial cell differentiation', 'hepatocyte apoptotic process', 'intrinsic apoptotic signaling pathway by p53 class mediator', 'positive regulation of apoptotic process', 'positive regulation of necroptotic process', 'protein autoprocessing', 'proteolysis', 'pyroptosis', 'regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway']
NAD-capped RNA hydrolase NUDT12
387
NAD-capped RNA hydrolase NUDT12
400
9.3
84
0.13
Q9BQG2Q9BQG2['circadian regulation of gene expression', 'methylguanosine-cap decapping', 'mRNA catabolic process', 'NAD biosynthesis via nicotinamide riboside salvage pathway', 'NAD catabolic process', 'NAD-cap decapping', 'NADH metabolic process', 'NADP catabolic process']['circadian regulation of gene expression', 'methylguanosine-cap decapping', 'mRNA catabolic process', 'NAD biosynthesis via nicotinamide riboside salvage pathway', 'NAD catabolic process', 'NAD-cap decapping', 'NADH metabolic process', 'NADP catabolic process']
Mothers against decapentaplegic homolog 4
401
Ski-like protein
327
9.3
71
0.15
Q13485P12757['activin receptor signaling pathway', 'adrenal gland development', 'aging', 'anatomical structure morphogenesis', 'atrioventricular canal development', 'atrioventricular valve formation', 'axon guidance', 'BMP signaling pathway', 'brainstem development', 'branching involved in ureteric bud morphogenesis', 'cardiac conduction system development', 'cell differentiation', 'cell population proliferation', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'cellular response to glucose stimulus', 'developmental growth', 'embryonic digit morphogenesis', 'endocardial cell differentiation', 'endothelial cell activation', 'epithelial to mesenchymal transition involved in endocardial cushion formation', 'ERK1 and ERK2 cascade', 'female gonad morphogenesis', 'formation of anatomical boundary', 'gastrulation with mouth forming second', 'in utero embryonic development', 'interleukin-6-mediated signaling pathway', 'intracellular signal transduction', 'left ventricular cardiac muscle tissue morphogenesis', 'mesendoderm development', 'metanephric mesenchyme morphogenesis', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of cardiac myofibril assembly', 'negative regulation of cell death', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of protein catabolic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'nephrogenic mesenchyme morphogenesis', 'neural crest cell differentiation', 'neuron fate commitment', 'osteoblast differentiation', 'outflow tract septum morphogenesis', 'ovarian follicle development', 'positive regulation of BMP signaling pathway', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of cell proliferation involved in heart valve morphogenesis', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of follicle-stimulating hormone secretion', 'positive regulation of histone H3-K4 methylation', 'positive regulation of histone H3-K9 acetylation', 'positive regulation of luteinizing hormone secretion', 'positive regulation of miRNA transcription', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta receptor signaling pathway', 'regulation of binding', 'regulation of hair follicle development', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to transforming growth factor beta', 'sebaceous gland development', 'secondary palate development', 'seminiferous tubule development', 'single fertilization', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'somite rostral/caudal axis specification', 'spermatogenesis', 'transcription by RNA polymerase II', 'transcription, DNA-templated', 'transforming growth factor beta receptor signaling pathway', 'uterus development', 'ventricular septum morphogenesis', 'wound healing']['blastocyst formation', 'extrinsic apoptotic signaling pathway via death domain receptors', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'lens fiber cell differentiation', 'lymphocyte homeostasis', 'negative regulation of BMP signaling pathway', 'negative regulation of cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'positive regulation of axonogenesis', 'positive regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'regulation of cell cycle', 'response to antibiotic', 'response to cytokine', 'response to growth factor', 'skeletal muscle tissue development', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Guanine nucleotide-binding protein G(i) subunit alpha-1
305
Guanine nucleotide-binding protein G(i) subunit alpha-1
305
9.7
50
0.21
P63096P63096['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell cycle', 'cell division', 'cellular response to forskolin', 'G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to cell cortex', 'regulation of cAMP-mediated signaling', 'regulation of mitotic spindle organization', 'response to peptide hormone']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell cycle', 'cell division', 'cellular response to forskolin', 'G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to cell cortex', 'regulation of cAMP-mediated signaling', 'regulation of mitotic spindle organization', 'response to peptide hormone']
Growth/differentiation factor 8
339
Growth/differentiation factor 8
281
9.7
74
0.14
O14793O14793['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'muscle organ development', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'muscle organ development', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
Sequestosome-1
154
Sequestosome-1
154
9.3
66
0.16
Q13501Q13501['aggrephagy', 'apoptotic process', 'autophagy', 'autophagy of mitochondrion', 'brown fat cell proliferation', 'cell differentiation', 'endosomal transport', 'endosome organization', 'energy homeostasis', 'immune system process', 'intracellular signal transduction', 'macroautophagy', 'mitophagy', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of apoptotic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'protein import into nucleus', 'protein localization', 'protein localization to perinuclear region of cytoplasm', 'protein phosphorylation', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of mitochondrion organization', 'regulation of protein complex stability', 'regulation of Ras protein signal transduction', 'response to ischemia', 'response to mitochondrial depolarisation', 'selective autophagy', 'temperature homeostasis', 'transcription by RNA polymerase II', 'ubiquitin-dependent protein catabolic process']['aggrephagy', 'apoptotic process', 'autophagy', 'autophagy of mitochondrion', 'brown fat cell proliferation', 'cell differentiation', 'endosomal transport', 'endosome organization', 'energy homeostasis', 'immune system process', 'intracellular signal transduction', 'macroautophagy', 'mitophagy', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of apoptotic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'protein import into nucleus', 'protein localization', 'protein localization to perinuclear region of cytoplasm', 'protein phosphorylation', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of mitochondrion organization', 'regulation of protein complex stability', 'regulation of Ras protein signal transduction', 'response to ischemia', 'response to mitochondrial depolarisation', 'selective autophagy', 'temperature homeostasis', 'transcription by RNA polymerase II', 'ubiquitin-dependent protein catabolic process']
Fibrinogen beta chain
87
Fibrinogen gamma-B chain
33
9.3
64
0.17
P02676P12799['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'innate immune response', 'platelet aggregation', 'protein polymerization']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'platelet aggregation', 'protein polymerization']
Protein PML
88
Protein PML
72
9.3
68
0.16
P29590P29590['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'apoptotic process', 'branching involved in mammary gland duct morphogenesis', 'cell fate commitment', 'cellular response to interleukin-4', 'cellular response to leukemia inhibitory factor', 'cellular senescence', 'circadian regulation of gene expression', 'common-partner SMAD protein phosphorylation', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'endoplasmic reticulum calcium ion homeostasis', 'entrainment of circadian clock by photoperiod', 'extrinsic apoptotic signaling pathway', 'fibroblast migration', 'innate immune response', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'intrinsic apoptotic signaling pathway in response to oxidative stress', 'maintenance of protein location in nucleus', 'myeloid cell differentiation', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of interleukin-1 beta production', 'negative regulation of mitotic cell cycle', 'negative regulation of telomerase activity', 'negative regulation of telomere maintenance via telomerase', 'negative regulation of transcription, DNA-templated', 'negative regulation of translation in response to oxidative stress', 'negative regulation of ubiquitin-dependent protein catabolic process', 'oncogene-induced cell senescence', 'PML body organization', 'positive regulation of apoptotic process involved in mammary gland involution', 'positive regulation of defense response to virus by host', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of fibroblast proliferation', 'positive regulation of histone deacetylation', 'positive regulation of peptidyl-lysine acetylation', 'positive regulation of protein localization to chromosome, telomeric region', 'positive regulation of signal transduction by p53 class mediator', 'positive regulation of telomere maintenance', 'positive regulation of transcription, DNA-templated', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein import into nucleus', 'protein stabilization', 'protein targeting', 'protein-containing complex assembly', 'protein-containing complex localization', 'regulation of calcium ion transport into cytosol', 'regulation of cell adhesion', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of double-strand break repair', 'regulation of transcription, DNA-templated', 'response to cytokine', 'response to gamma radiation', 'response to hypoxia', 'response to UV', 'retinoic acid receptor signaling pathway', 'suppression of viral release by host', 'transforming growth factor beta receptor signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'apoptotic process', 'branching involved in mammary gland duct morphogenesis', 'cell fate commitment', 'cellular response to interleukin-4', 'cellular response to leukemia inhibitory factor', 'cellular senescence', 'circadian regulation of gene expression', 'common-partner SMAD protein phosphorylation', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'endoplasmic reticulum calcium ion homeostasis', 'entrainment of circadian clock by photoperiod', 'extrinsic apoptotic signaling pathway', 'fibroblast migration', 'innate immune response', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'intrinsic apoptotic signaling pathway in response to oxidative stress', 'maintenance of protein location in nucleus', 'myeloid cell differentiation', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of interleukin-1 beta production', 'negative regulation of mitotic cell cycle', 'negative regulation of telomerase activity', 'negative regulation of telomere maintenance via telomerase', 'negative regulation of transcription, DNA-templated', 'negative regulation of translation in response to oxidative stress', 'negative regulation of ubiquitin-dependent protein catabolic process', 'oncogene-induced cell senescence', 'PML body organization', 'positive regulation of apoptotic process involved in mammary gland involution', 'positive regulation of defense response to virus by host', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of fibroblast proliferation', 'positive regulation of histone deacetylation', 'positive regulation of peptidyl-lysine acetylation', 'positive regulation of protein localization to chromosome, telomeric region', 'positive regulation of signal transduction by p53 class mediator', 'positive regulation of telomere maintenance', 'positive regulation of transcription, DNA-templated', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein import into nucleus', 'protein stabilization', 'protein targeting', 'protein-containing complex assembly', 'protein-containing complex localization', 'regulation of calcium ion transport into cytosol', 'regulation of cell adhesion', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of double-strand break repair', 'regulation of transcription, DNA-templated', 'response to cytokine', 'response to gamma radiation', 'response to hypoxia', 'response to UV', 'retinoic acid receptor signaling pathway', 'suppression of viral release by host', 'transforming growth factor beta receptor signaling pathway']
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
957
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
957
9.7
73
0.14
Q14432Q14432['apoptotic signaling pathway', 'cAMP-mediated signaling', 'cellular response to cGMP', 'cellular response to transforming growth factor beta stimulus', 'cGMP-mediated signaling', 'G protein-coupled receptor signaling pathway', 'lipid metabolic process', 'negative regulation of apoptotic process', 'negative regulation of cAMP-mediated signaling', 'negative regulation of vascular permeability', 'oocyte maturation', 'positive regulation of oocyte development', 'positive regulation of vascular permeability', 'regulation of meiotic nuclear division', 'regulation of ribonuclease activity', 'response to xenobiotic stimulus', 'signal transduction']['apoptotic signaling pathway', 'cAMP-mediated signaling', 'cellular response to cGMP', 'cellular response to transforming growth factor beta stimulus', 'cGMP-mediated signaling', 'G protein-coupled receptor signaling pathway', 'lipid metabolic process', 'negative regulation of apoptotic process', 'negative regulation of cAMP-mediated signaling', 'negative regulation of vascular permeability', 'oocyte maturation', 'positive regulation of oocyte development', 'positive regulation of vascular permeability', 'regulation of meiotic nuclear division', 'regulation of ribonuclease activity', 'response to xenobiotic stimulus', 'signal transduction']
C-C motif chemokine 5
57
C-C motif chemokine 5
57
9.0
61
0.18
P13501P13501['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'chemokine-mediated signaling pathway', 'chemotaxis', 'dendritic cell chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of innate immune response', 'positive regulation of macrophage chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of translational initiation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of viral genome replication', 'protein kinase B signaling', 'regulation of chronic inflammatory response', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to toxic substance', 'response to virus']['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'chemokine-mediated signaling pathway', 'chemotaxis', 'dendritic cell chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of innate immune response', 'positive regulation of macrophage chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of translational initiation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of viral genome replication', 'protein kinase B signaling', 'regulation of chronic inflammatory response', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to toxic substance', 'response to virus']
Brain-derived neurotrophic factor
196
Neurotrophin-3
248
9.0
87
0.13
P23560P20783['axon guidance', 'brain-derived neurotrophic factor receptor signaling pathway', 'collateral sprouting', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of apoptotic signaling pathway', 'negative regulation of myotube differentiation', 'negative regulation of neuron apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'nervous system development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of brain-derived neurotrophic factor receptor signaling pathway', 'positive regulation of collateral sprouting', 'positive regulation of neuron projection development', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of receptor binding', 'positive regulation of synapse assembly', 'regulation of neuron differentiation', 'regulation of protein localization to cell surface', 'synapse assembly', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of GTPase activity', 'activation of protein kinase B activity', 'cell-cell signaling', 'induction of positive chemotaxis', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of peptidyl-tyrosine phosphorylation', 'nerve development', 'nerve growth factor signaling pathway', 'nervous system development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of MAP kinase activity', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of receptor internalization', 'regulation of apoptotic process', 'regulation of neuron differentiation', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Glucocorticoid receptor
476
Glucocorticoid receptor
492
9.8
72
0.14
P06536P06536['adrenal gland development', 'aging', 'androgen metabolic process', 'brain development', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to magnesium ion', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin remodeling', 'circadian rhythm', 'epigenetic maintenance of chromatin in transcription-competent conformation', 'female pregnancy', 'glucocorticoid metabolic process', 'glucocorticoid receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lung development', 'mammary gland duct morphogenesis', 'maternal behavior', 'muscle atrophy', 'negative regulation of apoptotic process', 'negative regulation of synaptic plasticity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular permeability', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of dendritic spine development', 'positive regulation of glucocorticoid receptor signaling pathway', 'positive regulation of glutamate secretion', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'protein-containing complex assembly', 'regulation of cell population proliferation', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of glucose metabolic process', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to activity', 'response to arsenic-containing substance', 'response to calcium ion', 'response to corticosterone', 'response to dexamethasone', 'response to electrical stimulus', 'response to inactivity', 'response to insulin', 'response to mercury ion', 'response to radiation']['adrenal gland development', 'aging', 'androgen metabolic process', 'brain development', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to magnesium ion', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin remodeling', 'circadian rhythm', 'epigenetic maintenance of chromatin in transcription-competent conformation', 'female pregnancy', 'glucocorticoid metabolic process', 'glucocorticoid receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lung development', 'mammary gland duct morphogenesis', 'maternal behavior', 'muscle atrophy', 'negative regulation of apoptotic process', 'negative regulation of synaptic plasticity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular permeability', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of dendritic spine development', 'positive regulation of glucocorticoid receptor signaling pathway', 'positive regulation of glutamate secretion', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'protein-containing complex assembly', 'regulation of cell population proliferation', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of glucose metabolic process', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to activity', 'response to arsenic-containing substance', 'response to calcium ion', 'response to corticosterone', 'response to dexamethasone', 'response to electrical stimulus', 'response to inactivity', 'response to insulin', 'response to mercury ion', 'response to radiation']
Lysine-specific demethylase 2A
333
Lysine-specific demethylase 2A
477
9.8
69
0.15
P59997P59997['chromatin organization', 'circadian regulation of gene expression', 'double-strand break repair via nonhomologous end joining', 'heart looping', 'histone H3-K36 demethylation', 'in utero embryonic development', 'multicellular organism growth', 'negative regulation of apoptotic process', 'negative regulation of gene expression', 'negative regulation of transcription by competitive promoter binding', 'neural tube closure', 'neuroepithelial cell differentiation', 'neuron differentiation', 'positive regulation of gene expression', 'positive regulation of histone ubiquitination', 'protein demethylation', 'regulation of circadian rhythm', 'regulation of transcription by RNA polymerase II']['chromatin organization', 'circadian regulation of gene expression', 'double-strand break repair via nonhomologous end joining', 'heart looping', 'histone H3-K36 demethylation', 'in utero embryonic development', 'multicellular organism growth', 'negative regulation of apoptotic process', 'negative regulation of gene expression', 'negative regulation of transcription by competitive promoter binding', 'neural tube closure', 'neuroepithelial cell differentiation', 'neuron differentiation', 'positive regulation of gene expression', 'positive regulation of histone ubiquitination', 'protein demethylation', 'regulation of circadian rhythm', 'regulation of transcription by RNA polymerase II']
Sorcin
57
Sorcin
75
9.8
75
0.14
P30626P30626['action potential', 'calcium ion transport', 'cytoplasmic sequestering of transcription factor', 'heart development', 'intracellular sequestering of iron ion', 'muscle organ development', 'negative regulation of cardiac muscle contraction', 'negative regulation of heart rate', 'negative regulation of ryanodine-sensitive calcium-release channel activity', 'negative regulation of transcription regulatory region DNA binding', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of release of sequestered calcium ion into cytosol', 'regulation of calcium ion transport', 'regulation of cardiac muscle cell contraction', 'regulation of cell communication by electrical coupling', 'regulation of cell communication by electrical coupling involved in cardiac conduction', 'regulation of heart contraction', 'regulation of high voltage-gated calcium channel activity', 'regulation of relaxation of muscle', 'regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum', 'regulation of striated muscle contraction', 'signal transduction']['action potential', 'calcium ion transport', 'cytoplasmic sequestering of transcription factor', 'heart development', 'intracellular sequestering of iron ion', 'muscle organ development', 'negative regulation of cardiac muscle contraction', 'negative regulation of heart rate', 'negative regulation of ryanodine-sensitive calcium-release channel activity', 'negative regulation of transcription regulatory region DNA binding', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of release of sequestered calcium ion into cytosol', 'regulation of calcium ion transport', 'regulation of cardiac muscle cell contraction', 'regulation of cell communication by electrical coupling', 'regulation of cell communication by electrical coupling involved in cardiac conduction', 'regulation of heart contraction', 'regulation of high voltage-gated calcium channel activity', 'regulation of relaxation of muscle', 'regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum', 'regulation of striated muscle contraction', 'signal transduction']
Interleukin-17A
99
Interleukin-17F
154
9.0
84
0.13
Q16552Q96PD4['adaptive immune response', 'apoptotic process', 'cell death', 'cell-cell signaling', 'cellular response to interleukin-1', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'fibroblast activation', 'granulocyte migration', 'immune response', 'inflammatory response', 'innate immune response', 'interleukin-17-mediated signaling pathway', 'intestinal epithelial structure maintenance', 'Notch signaling pathway', 'positive regulation of antimicrobial peptide production', 'positive regulation of bicellular tight junction assembly', 'positive regulation of chemokine (C-X-C motif) ligand 1 production', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-16 production', 'positive regulation of interleukin-23 production', 'positive regulation of interleukin-6 production', 'positive regulation of osteoclast differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production']['adaptive immune response', 'cartilage development', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'inflammatory response', 'innate immune response', 'interleukin-17-mediated signaling pathway', 'negative regulation of angiogenesis', 'positive regulation of antimicrobial peptide production', 'positive regulation of chemokine (C-X-C motif) ligand 1 production', 'positive regulation of cytokine production', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of interleukin-6 production', 'positive regulation of lymphotoxin A production', 'positive regulation of transcription by RNA polymerase II', 'regulation of granulocyte macrophage colony-stimulating factor production', 'regulation of interleukin-2 production', 'regulation of interleukin-6 production', 'regulation of interleukin-8 production', 'regulation of transforming growth factor beta receptor signaling pathway']
Transforming growth factor beta-1 proprotein
389
Transforming growth factor beta-1 proprotein
355
9.8
86
0.12
P01137P01137['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']
Cytochrome c, somatic
18
Cytochrome c, somatic
18
9.0
55
0.2
P62898P62898['activation of cysteine-type endopeptidase activity', 'activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c', 'apoptotic process', 'glial cell apoptotic process', 'hydrogen peroxide metabolic process', 'mitochondrial electron transport, cytochrome c to oxygen', 'mitochondrial electron transport, ubiquinol to cytochrome c', 'negative regulation of hydrogen peroxide biosynthetic process', 'positive regulation of cellular respiration', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'regulation of protein binding', 'response to carbon monoxide', 'response to copper ion', 'response to gravity', 'response to ischemia', 'response to oxidative stress']['activation of cysteine-type endopeptidase activity', 'activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c', 'apoptotic process', 'glial cell apoptotic process', 'hydrogen peroxide metabolic process', 'mitochondrial electron transport, cytochrome c to oxygen', 'mitochondrial electron transport, ubiquinol to cytochrome c', 'negative regulation of hydrogen peroxide biosynthetic process', 'positive regulation of cellular respiration', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'regulation of protein binding', 'response to carbon monoxide', 'response to copper ion', 'response to gravity', 'response to ischemia', 'response to oxidative stress']
A disintegrin and metalloproteinase with thrombospondin motifs 5
376
A disintegrin and metalloproteinase with thrombospondin motifs 5
342
9.0
63
0.18
Q9UNA0Q9UNA0['defense response to bacterium', 'extracellular matrix disassembly', 'extracellular matrix organization', 'myoblast fusion', 'negative regulation of cold-induced thermogenesis', 'proteolysis', 'tooth eruption']['defense response to bacterium', 'extracellular matrix disassembly', 'extracellular matrix organization', 'myoblast fusion', 'negative regulation of cold-induced thermogenesis', 'proteolysis', 'tooth eruption']
Kunitz-type protease inhibitor 1
259
Suppressor of tumorigenicity 14 protein
641
9.0
98
0.11
O43278Q9Y5Y6['branching involved in labyrinthine layer morphogenesis', 'cellular response to BMP stimulus', 'epidermis development', 'epithelium development', 'extracellular matrix organization', 'negative regulation of neural precursor cell proliferation', 'neural tube closure', 'placenta blood vessel development', 'positive regulation of glial cell differentiation']['epithelial cell morphogenesis involved in placental branching', 'keratinocyte differentiation', 'neural tube closure', 'protein catabolic process', 'proteolysis']
Mucin-2
1088
Mucin-2
1117
9.8
76
0.13
Q02817Q02817['maintenance of gastrointestinal epithelium']['maintenance of gastrointestinal epithelium']
Importin subunit alpha-3
248
Importin subunit alpha-3
248
9.0
84
0.13
O00629O00629['NLS-bearing protein import into nucleus', 'protein import into nucleus']['NLS-bearing protein import into nucleus', 'protein import into nucleus']
C-C motif chemokine 3
34
C-C motif chemokine 3
33
9.8
77
0.13
P10147P10147['astrocyte cell migration', 'calcium ion transport', 'calcium-mediated signaling', 'cell activation', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytoskeleton organization', 'eosinophil chemotaxis', 'eosinophil degranulation', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'granulocyte chemotaxis', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'negative regulation of osteoclast differentiation', 'neutrophil chemotaxis', 'osteoblast differentiation', 'positive regulation of calcium ion import', 'positive regulation of calcium ion transport', 'positive regulation of calcium-mediated signaling', 'positive regulation of cell migration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of GTPase activity', 'positive regulation of inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of microglial cell activation', 'positive regulation of microglial cell migration', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of protein kinase B signaling', 'positive regulation of tumor necrosis factor production', 'protein kinase B signaling', 'regulation of behavior', 'regulation of cell shape', 'regulation of sensory perception of pain', 'release of sequestered calcium ion into cytosol by sarcoplasmic reticulum', 'response to cholesterol', 'response to toxic substance', 'signaling', 'T cell chemotaxis']['astrocyte cell migration', 'calcium ion transport', 'calcium-mediated signaling', 'cell activation', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytoskeleton organization', 'eosinophil chemotaxis', 'eosinophil degranulation', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'granulocyte chemotaxis', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'negative regulation of osteoclast differentiation', 'neutrophil chemotaxis', 'osteoblast differentiation', 'positive regulation of calcium ion import', 'positive regulation of calcium ion transport', 'positive regulation of calcium-mediated signaling', 'positive regulation of cell migration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of GTPase activity', 'positive regulation of inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of microglial cell activation', 'positive regulation of microglial cell migration', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of protein kinase B signaling', 'positive regulation of tumor necrosis factor production', 'protein kinase B signaling', 'regulation of behavior', 'regulation of cell shape', 'regulation of sensory perception of pain', 'release of sequestered calcium ion into cytosol by sarcoplasmic reticulum', 'response to cholesterol', 'response to toxic substance', 'signaling', 'T cell chemotaxis']
Suppressor of cytokine signaling 4
393
Elongin-C
112
9.0
nan
nan
Q8WXH5Q15369['intracellular signal transduction', 'negative regulation of epidermal growth factor-activated receptor activity', 'phosphatidylinositol phosphate biosynthetic process', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'protein ubiquitination', 'regulation of growth']['protein ubiquitination', 'regulation of transcription by RNA polymerase II', 'transcription initiation from RNA polymerase II promoter', 'ubiquitin-dependent protein catabolic process']
Hemoglobin subunit alpha
104
Hemoglobin subunit beta
112
9.1
84
0.13
P60529P60524['cellular oxidant detoxification', 'hydrogen peroxide catabolic process']['cellular oxidant detoxification', 'hydrogen peroxide catabolic process']
Vascular endothelial growth factor A
77
Vascular endothelial growth factor A
94
9.1
64
0.17
P15692P15692['activation of protein kinase activity', 'angiogenesis', 'artery morphogenesis', 'basophil chemotaxis', 'branching involved in blood vessel morphogenesis', 'camera-type eye morphogenesis', 'cardiac muscle cell development', 'cardiac vascular smooth muscle cell development', 'cell maturation', 'cell migration involved in sprouting angiogenesis', 'cellular response to hypoxia', 'cellular response to vascular endothelial growth factor stimulus', 'cellular stress response to acid chemical', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'coronary vein morphogenesis', 'dopaminergic neuron differentiation', 'endothelial cell chemotaxis', 'epithelial cell differentiation', 'eye photoreceptor cell development', 'heart morphogenesis', 'in utero embryonic development', 'induction of positive chemotaxis', 'kidney development', 'lactation', 'lung development', 'lymph vessel morphogenesis', 'macrophage differentiation', 'mammary gland alveolus development', 'mesoderm development', 'monocyte differentiation', 'motor neuron migration', 'negative regulation of adherens junction organization', 'negative regulation of apoptotic process', 'negative regulation of blood-brain barrier permeability', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of establishment of endothelial barrier', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'outflow tract morphogenesis', 'ovarian follicle development', 'positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell migration by vascular endothelial growth factor signaling pathway', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway', 'positive regulation of cold-induced thermogenesis', 'positive regulation of CREB transcription factor activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of histone deacetylase activity', 'positive regulation of leukocyte migration', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of neuroblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of positive chemotaxis', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C signaling', 'positive regulation of protein kinase D signaling', 'positive regulation of protein localization to early endosome', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor internalization', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of trophoblast cell migration', 'positive regulation of vascular permeability', 'post-embryonic camera-type eye development', 'primitive erythrocyte differentiation', 'regulation of cell shape', 'regulation of nitric oxide mediated signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of transcription by RNA polymerase II', 'response to hypoxia', 'sprouting angiogenesis', 'surfactant homeostasis', 'tube formation', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway']['activation of protein kinase activity', 'angiogenesis', 'artery morphogenesis', 'basophil chemotaxis', 'branching involved in blood vessel morphogenesis', 'camera-type eye morphogenesis', 'cardiac muscle cell development', 'cardiac vascular smooth muscle cell development', 'cell maturation', 'cell migration involved in sprouting angiogenesis', 'cellular response to hypoxia', 'cellular response to vascular endothelial growth factor stimulus', 'cellular stress response to acid chemical', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'coronary vein morphogenesis', 'dopaminergic neuron differentiation', 'endothelial cell chemotaxis', 'epithelial cell differentiation', 'eye photoreceptor cell development', 'heart morphogenesis', 'in utero embryonic development', 'induction of positive chemotaxis', 'kidney development', 'lactation', 'lung development', 'lymph vessel morphogenesis', 'macrophage differentiation', 'mammary gland alveolus development', 'mesoderm development', 'monocyte differentiation', 'motor neuron migration', 'negative regulation of adherens junction organization', 'negative regulation of apoptotic process', 'negative regulation of blood-brain barrier permeability', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of establishment of endothelial barrier', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'outflow tract morphogenesis', 'ovarian follicle development', 'positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell migration by vascular endothelial growth factor signaling pathway', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway', 'positive regulation of cold-induced thermogenesis', 'positive regulation of CREB transcription factor activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of histone deacetylase activity', 'positive regulation of leukocyte migration', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of neuroblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of positive chemotaxis', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C signaling', 'positive regulation of protein kinase D signaling', 'positive regulation of protein localization to early endosome', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor internalization', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of trophoblast cell migration', 'positive regulation of vascular permeability', 'post-embryonic camera-type eye development', 'primitive erythrocyte differentiation', 'regulation of cell shape', 'regulation of nitric oxide mediated signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of transcription by RNA polymerase II', 'response to hypoxia', 'sprouting angiogenesis', 'surfactant homeostasis', 'tube formation', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway']
Xanthine dehydrogenase/oxidase
78
Xanthine dehydrogenase/oxidase
280
9.1
91
0.12
P80457P80457['xanthine catabolic process']['xanthine catabolic process']
Brain-derived neurotrophic factor
239
Neurotrophin-3
205
9.1
85
0.13
P23560P20783['axon guidance', 'brain-derived neurotrophic factor receptor signaling pathway', 'collateral sprouting', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of apoptotic signaling pathway', 'negative regulation of myotube differentiation', 'negative regulation of neuron apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'nervous system development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of brain-derived neurotrophic factor receptor signaling pathway', 'positive regulation of collateral sprouting', 'positive regulation of neuron projection development', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of receptor binding', 'positive regulation of synapse assembly', 'regulation of neuron differentiation', 'regulation of protein localization to cell surface', 'synapse assembly', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of GTPase activity', 'activation of protein kinase B activity', 'cell-cell signaling', 'induction of positive chemotaxis', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of peptidyl-tyrosine phosphorylation', 'nerve development', 'nerve growth factor signaling pathway', 'nervous system development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of MAP kinase activity', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of receptor internalization', 'regulation of apoptotic process', 'regulation of neuron differentiation', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway']
C-C motif chemokine 14
35
C-C motif chemokine 14
36
9.8
77
0.13
Q16627Q16627['cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']['cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']
Bone morphogenetic protein 6
477
Bone morphogenetic protein 6
512
9.1
86
0.13
P22004P22004['BMP signaling pathway', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'cellular response to iron ion', 'cellular response to mechanical stimulus', 'endochondral ossification', 'eye development', 'immune response', 'inflammatory response', 'kidney development', 'male genitalia development', 'multicellular organismal iron ion homeostasis', 'negative regulation of adherens junction organization', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of transcription by RNA polymerase II', 'neuron differentiation', 'osteoblast differentiation', 'positive regulation of aldosterone biosynthetic process', 'positive regulation of aldosterone secretion', 'positive regulation of bone mineralization', 'positive regulation of cell population proliferation', 'positive regulation of chondrocyte differentiation', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of gene expression', 'positive regulation of lipopolysaccharide-mediated signaling pathway', 'positive regulation of neuron differentiation', 'positive regulation of osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vascular permeability', 'response to activity', 'response to glucocorticoid', 'response to magnesium ion', 'response to retinoic acid', 'skeletal system development', 'SMAD protein signal transduction', 'type B pancreatic cell development']['BMP signaling pathway', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'cellular response to iron ion', 'cellular response to mechanical stimulus', 'endochondral ossification', 'eye development', 'immune response', 'inflammatory response', 'kidney development', 'male genitalia development', 'multicellular organismal iron ion homeostasis', 'negative regulation of adherens junction organization', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of transcription by RNA polymerase II', 'neuron differentiation', 'osteoblast differentiation', 'positive regulation of aldosterone biosynthetic process', 'positive regulation of aldosterone secretion', 'positive regulation of bone mineralization', 'positive regulation of cell population proliferation', 'positive regulation of chondrocyte differentiation', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of gene expression', 'positive regulation of lipopolysaccharide-mediated signaling pathway', 'positive regulation of neuron differentiation', 'positive regulation of osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vascular permeability', 'response to activity', 'response to glucocorticoid', 'response to magnesium ion', 'response to retinoic acid', 'skeletal system development', 'SMAD protein signal transduction', 'type B pancreatic cell development']
Anionic trypsin-2
48
Pancreatic trypsin inhibitor
49
9.1
94
0.12
P00763P00974['collagen catabolic process', 'digestion', 'proteolysis', 'response to nutrient']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Ketohexokinase
32
Ketohexokinase
98
9.1
75
0.15
P50053P50053['fructose metabolic process', 'regulation of glycogen metabolic process', 'response to fructose', 'response to glucose', 'response to insulin', 'response to sucrose', 'response to zinc ion']['fructose metabolic process', 'regulation of glycogen metabolic process', 'response to fructose', 'response to glucose', 'response to insulin', 'response to sucrose', 'response to zinc ion']
Gremlin-2
120
Gremlin-2
120
9.1
66
0.17
O88273O88273['animal organ morphogenesis', 'cytokine-mediated signaling pathway', 'determination of dorsal identity', 'embryonic body morphogenesis', 'negative regulation of BMP signaling pathway', 'regulation of cytokine activity', 'sequestering of BMP from receptor via BMP binding']['animal organ morphogenesis', 'cytokine-mediated signaling pathway', 'determination of dorsal identity', 'embryonic body morphogenesis', 'negative regulation of BMP signaling pathway', 'regulation of cytokine activity', 'sequestering of BMP from receptor via BMP binding']
Dihydrolipoyl dehydrogenase, mitochondrial
388
Dihydrolipoyl dehydrogenase, mitochondrial
484
9.1
82
0.13
P09622P09622['acetyl-CoA biosynthetic process from pyruvate', 'branched-chain amino acid catabolic process', 'cell redox homeostasis', 'gastrulation', 'histone succinylation', 'mitochondrial acetyl-CoA biosynthetic process from pyruvate', 'mitochondrial electron transport, NADH to ubiquinone', 'proteolysis', 'regulation of membrane potential', 'sperm capacitation']['acetyl-CoA biosynthetic process from pyruvate', 'branched-chain amino acid catabolic process', 'cell redox homeostasis', 'gastrulation', 'histone succinylation', 'mitochondrial acetyl-CoA biosynthetic process from pyruvate', 'mitochondrial electron transport, NADH to ubiquinone', 'proteolysis', 'regulation of membrane potential', 'sperm capacitation']
Neurogenic locus notch homolog protein 1
1549
Neurogenic locus notch homolog protein 1
1536
9.8
87
0.12
P46531P46531['animal organ regeneration', 'aortic valve morphogenesis', 'apoptotic process involved in embryonic digit morphogenesis', 'arterial endothelial cell differentiation', 'astrocyte differentiation', 'atrioventricular node development', 'atrioventricular valve morphogenesis', 'auditory receptor cell fate commitment', 'axon guidance', 'branching morphogenesis of an epithelial tube', 'calcium-ion regulated exocytosis', 'cardiac atrium morphogenesis', 'cardiac chamber formation', 'cardiac epithelial to mesenchymal transition', 'cardiac left ventricle morphogenesis', 'cardiac muscle cell myoblast differentiation', 'cardiac muscle cell proliferation', 'cardiac muscle tissue morphogenesis', 'cardiac right atrium morphogenesis', 'cardiac right ventricle formation', 'cardiac septum morphogenesis', 'cardiac vascular smooth muscle cell development', 'cardiac ventricle morphogenesis', 'cell differentiation in spinal cord', 'cell migration involved in endocardial cushion formation', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to tumor cell', 'cellular response to vascular endothelial growth factor stimulus', 'cilium assembly', 'collecting duct development', 'compartment pattern specification', 'coronary artery morphogenesis', 'coronary sinus valve morphogenesis', 'coronary vein morphogenesis', 'determination of left/right symmetry', 'distal tubule development', 'embryonic hindlimb morphogenesis', 'endocardial cell differentiation', 'endocardial cushion morphogenesis', 'endocardium development', 'endocardium morphogenesis', 'endoderm development', 'epidermal cell fate specification', 'epithelial cell fate commitment', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'epithelial to mesenchymal transition involved in endocardial cushion formation', 'forebrain development', 'foregut morphogenesis', 'glomerular mesangial cell development', 'growth involved in heart morphogenesis', 'hair follicle morphogenesis', 'heart development', 'heart looping', 'heart trabecula morphogenesis', 'homeostasis of number of cells within a tissue', 'humoral immune response', 'immune response', 'in utero embryonic development', 'inflammatory response to antigenic stimulus', 'inhibition of neuroepithelial cell differentiation', 'interleukin-17-mediated signaling pathway', 'keratinocyte differentiation', 'left/right axis specification', 'liver development', 'lung development', 'mesenchymal cell development', 'mitral valve formation', 'negative regulation of anoikis', 'negative regulation of biomineral tissue development', 'negative regulation of BMP signaling pathway', 'negative regulation of calcium ion-dependent exocytosis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of catalytic activity', 'negative regulation of cell adhesion molecule production', 'negative regulation of cell migration involved in sprouting angiogenesis', 'negative regulation of cell population proliferation', 'negative regulation of cell proliferation involved in heart valve morphogenesis', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cell-substrate adhesion', 'negative regulation of cold-induced thermogenesis', 'negative regulation of endothelial cell chemotaxis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix constituent secretion', 'negative regulation of gene expression', 'negative regulation of glial cell proliferation', 'negative regulation of inner ear auditory receptor cell differentiation', 'negative regulation of myoblast differentiation', 'negative regulation of myotube differentiation', 'negative regulation of neurogenesis', 'negative regulation of oligodendrocyte differentiation', 'negative regulation of ossification', 'negative regulation of osteoblast differentiation', 'negative regulation of photoreceptor cell differentiation', 'negative regulation of pro-B cell differentiation', 'negative regulation of stem cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube development', 'neuroendocrine cell differentiation', 'neuronal stem cell population maintenance', 'Notch signaling involved in heart development', 'Notch signaling pathway', 'Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation', 'oligodendrocyte differentiation', 'outflow tract morphogenesis', 'pericardium morphogenesis', 'positive regulation of aorta morphogenesis', 'positive regulation of apoptotic process involved in morphogenesis', 'positive regulation of astrocyte differentiation', 'positive regulation of BMP signaling pathway', 'positive regulation of cardiac epithelial to mesenchymal transition', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell differentiation', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of keratinocyte differentiation', 'positive regulation of neuroblast proliferation', 'positive regulation of Notch signaling pathway', 'positive regulation of Ras protein signal transduction', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription of Notch receptor target', 'positive regulation of transcription, DNA-templated', 'positive regulation of viral genome replication', 'prostate gland epithelium morphogenesis', 'protein catabolic process', 'protein import into nucleus', 'pulmonary valve morphogenesis', 'regulation of epithelial cell proliferation involved in prostate gland development', 'regulation of extracellular matrix assembly', 'regulation of somitogenesis', 'regulation of stem cell proliferation', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to corticosteroid', 'response to lipopolysaccharide', 'response to muramyl dipeptide', 'retinal cone cell differentiation', 'secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development', 'skeletal muscle cell differentiation', 'somatic stem cell division', 'spermatogenesis', 'sprouting angiogenesis', 'T-helper 17 type immune response', 'tissue regeneration', 'transcription by RNA polymerase II', 'tube formation', 'vasculogenesis involved in coronary vascular morphogenesis', 'venous endothelial cell differentiation', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis']['animal organ regeneration', 'aortic valve morphogenesis', 'apoptotic process involved in embryonic digit morphogenesis', 'arterial endothelial cell differentiation', 'astrocyte differentiation', 'atrioventricular node development', 'atrioventricular valve morphogenesis', 'auditory receptor cell fate commitment', 'axon guidance', 'branching morphogenesis of an epithelial tube', 'calcium-ion regulated exocytosis', 'cardiac atrium morphogenesis', 'cardiac chamber formation', 'cardiac epithelial to mesenchymal transition', 'cardiac left ventricle morphogenesis', 'cardiac muscle cell myoblast differentiation', 'cardiac muscle cell proliferation', 'cardiac muscle tissue morphogenesis', 'cardiac right atrium morphogenesis', 'cardiac right ventricle formation', 'cardiac septum morphogenesis', 'cardiac vascular smooth muscle cell development', 'cardiac ventricle morphogenesis', 'cell differentiation in spinal cord', 'cell migration involved in endocardial cushion formation', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to tumor cell', 'cellular response to vascular endothelial growth factor stimulus', 'cilium assembly', 'collecting duct development', 'compartment pattern specification', 'coronary artery morphogenesis', 'coronary sinus valve morphogenesis', 'coronary vein morphogenesis', 'determination of left/right symmetry', 'distal tubule development', 'embryonic hindlimb morphogenesis', 'endocardial cell differentiation', 'endocardial cushion morphogenesis', 'endocardium development', 'endocardium morphogenesis', 'endoderm development', 'epidermal cell fate specification', 'epithelial cell fate commitment', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'epithelial to mesenchymal transition involved in endocardial cushion formation', 'forebrain development', 'foregut morphogenesis', 'glomerular mesangial cell development', 'growth involved in heart morphogenesis', 'hair follicle morphogenesis', 'heart development', 'heart looping', 'heart trabecula morphogenesis', 'homeostasis of number of cells within a tissue', 'humoral immune response', 'immune response', 'in utero embryonic development', 'inflammatory response to antigenic stimulus', 'inhibition of neuroepithelial cell differentiation', 'interleukin-17-mediated signaling pathway', 'keratinocyte differentiation', 'left/right axis specification', 'liver development', 'lung development', 'mesenchymal cell development', 'mitral valve formation', 'negative regulation of anoikis', 'negative regulation of biomineral tissue development', 'negative regulation of BMP signaling pathway', 'negative regulation of calcium ion-dependent exocytosis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of catalytic activity', 'negative regulation of cell adhesion molecule production', 'negative regulation of cell migration involved in sprouting angiogenesis', 'negative regulation of cell population proliferation', 'negative regulation of cell proliferation involved in heart valve morphogenesis', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cell-substrate adhesion', 'negative regulation of cold-induced thermogenesis', 'negative regulation of endothelial cell chemotaxis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix constituent secretion', 'negative regulation of gene expression', 'negative regulation of glial cell proliferation', 'negative regulation of inner ear auditory receptor cell differentiation', 'negative regulation of myoblast differentiation', 'negative regulation of myotube differentiation', 'negative regulation of neurogenesis', 'negative regulation of oligodendrocyte differentiation', 'negative regulation of ossification', 'negative regulation of osteoblast differentiation', 'negative regulation of photoreceptor cell differentiation', 'negative regulation of pro-B cell differentiation', 'negative regulation of stem cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube development', 'neuroendocrine cell differentiation', 'neuronal stem cell population maintenance', 'Notch signaling involved in heart development', 'Notch signaling pathway', 'Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation', 'oligodendrocyte differentiation', 'outflow tract morphogenesis', 'pericardium morphogenesis', 'positive regulation of aorta morphogenesis', 'positive regulation of apoptotic process involved in morphogenesis', 'positive regulation of astrocyte differentiation', 'positive regulation of BMP signaling pathway', 'positive regulation of cardiac epithelial to mesenchymal transition', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell differentiation', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of keratinocyte differentiation', 'positive regulation of neuroblast proliferation', 'positive regulation of Notch signaling pathway', 'positive regulation of Ras protein signal transduction', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription of Notch receptor target', 'positive regulation of transcription, DNA-templated', 'positive regulation of viral genome replication', 'prostate gland epithelium morphogenesis', 'protein catabolic process', 'protein import into nucleus', 'pulmonary valve morphogenesis', 'regulation of epithelial cell proliferation involved in prostate gland development', 'regulation of extracellular matrix assembly', 'regulation of somitogenesis', 'regulation of stem cell proliferation', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to corticosteroid', 'response to lipopolysaccharide', 'response to muramyl dipeptide', 'retinal cone cell differentiation', 'secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development', 'skeletal muscle cell differentiation', 'somatic stem cell division', 'spermatogenesis', 'sprouting angiogenesis', 'T-helper 17 type immune response', 'tissue regeneration', 'transcription by RNA polymerase II', 'tube formation', 'vasculogenesis involved in coronary vascular morphogenesis', 'venous endothelial cell differentiation', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis']
Growth/differentiation factor 2
428
Growth/differentiation factor 2
392
9.8
89
0.11
Q9UK05Q9UK05['activin receptor signaling pathway', 'angiogenesis', 'blood vessel morphogenesis', 'BMP signaling pathway', 'branching involved in blood vessel morphogenesis', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'negative regulation of angiogenesis', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell growth', 'negative regulation of DNA biosynthetic process', 'negative regulation of DNA replication', 'negative regulation of endothelial cell migration', 'negative regulation of endothelial cell proliferation', 'ossification', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of angiogenesis', 'positive regulation of BMP signaling pathway', 'positive regulation of cartilage development', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of interleukin-8 production', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'SMAD protein signal transduction', 'transcription by RNA polymerase II', 'vasculogenesis']['activin receptor signaling pathway', 'angiogenesis', 'blood vessel morphogenesis', 'BMP signaling pathway', 'branching involved in blood vessel morphogenesis', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'negative regulation of angiogenesis', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell growth', 'negative regulation of DNA biosynthetic process', 'negative regulation of DNA replication', 'negative regulation of endothelial cell migration', 'negative regulation of endothelial cell proliferation', 'ossification', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of angiogenesis', 'positive regulation of BMP signaling pathway', 'positive regulation of cartilage development', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of interleukin-8 production', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'SMAD protein signal transduction', 'transcription by RNA polymerase II', 'vasculogenesis']
Hemoglobin subunit alpha
111
Hemoglobin subunit beta-A/B
112
9.0
78
0.14
P07405P07412['cellular oxidant detoxification', 'hydrogen peroxide catabolic process']['cellular oxidant detoxification', 'hydrogen peroxide catabolic process']
Kunitz-type protease inhibitor 2
47
Trypsin-3
105
9.1
96
0.12
O43291P35030['basement membrane organization', 'cellular response to BMP stimulus', 'epithelial cell morphogenesis involved in placental branching', 'establishment or maintenance of cell polarity', 'negative regulation of cell motility', 'negative regulation of cell-cell adhesion', 'negative regulation of neural precursor cell proliferation', 'neural tube closure']['antimicrobial humoral response', 'digestion', 'endothelial cell migration', 'proteolysis', 'zymogen activation']
Growth/differentiation factor 15
273
Growth/differentiation factor 15
211
9.8
81
0.13
Q99988Q99988['BMP signaling pathway', 'cell-cell signaling', 'glial cell-derived neurotrophic factor receptor signaling pathway', 'negative regulation of growth hormone receptor signaling pathway', 'negative regulation of multicellular organism growth', 'positive regulation of MAPK cascade', 'positive regulation of myoblast fusion', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein kinase B signaling', 'reduction of food intake in response to dietary excess', 'signal transduction', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['BMP signaling pathway', 'cell-cell signaling', 'glial cell-derived neurotrophic factor receptor signaling pathway', 'negative regulation of growth hormone receptor signaling pathway', 'negative regulation of multicellular organism growth', 'positive regulation of MAPK cascade', 'positive regulation of myoblast fusion', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein kinase B signaling', 'reduction of food intake in response to dietary excess', 'signal transduction', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
Protein arginine N-methyltransferase 5
22
Methylosome protein 50
53
9.8
72
0.14
O14744Q9BQA1['chromatin organization', 'circadian regulation of gene expression', 'DNA-templated transcription, termination', 'endothelial cell activation', 'Golgi ribbon formation', 'histone arginine methylation', 'histone H4-R3 methylation', 'liver regeneration', 'negative regulation of cell differentiation', 'peptidyl-arginine methylation', 'peptidyl-arginine N-methylation', 'positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway', 'positive regulation of mRNA splicing, via spliceosome', 'positive regulation of oligodendrocyte differentiation', 'regulation of DNA methylation', 'regulation of ERK1 and ERK2 cascade', 'regulation of mitotic nuclear division', 'regulation of signal transduction by p53 class mediator', 'regulation of transcription, DNA-templated', 'spliceosomal snRNP assembly']['epithelial cell proliferation involved in prostate gland development', 'histone H4-R3 methylation', 'negative regulation of epithelial cell proliferation involved in prostate gland development', 'oocyte axis specification', 'positive regulation of cell population proliferation', 'positive regulation of mRNA splicing, via spliceosome', 'regulation of transcription by RNA polymerase II', 'secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development', 'spliceosomal snRNP assembly']
Vascular endothelial growth factor A
87
Vascular endothelial growth factor A
77
9.1
71
0.16
P15692P15692['activation of protein kinase activity', 'angiogenesis', 'artery morphogenesis', 'basophil chemotaxis', 'branching involved in blood vessel morphogenesis', 'camera-type eye morphogenesis', 'cardiac muscle cell development', 'cardiac vascular smooth muscle cell development', 'cell maturation', 'cell migration involved in sprouting angiogenesis', 'cellular response to hypoxia', 'cellular response to vascular endothelial growth factor stimulus', 'cellular stress response to acid chemical', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'coronary vein morphogenesis', 'dopaminergic neuron differentiation', 'endothelial cell chemotaxis', 'epithelial cell differentiation', 'eye photoreceptor cell development', 'heart morphogenesis', 'in utero embryonic development', 'induction of positive chemotaxis', 'kidney development', 'lactation', 'lung development', 'lymph vessel morphogenesis', 'macrophage differentiation', 'mammary gland alveolus development', 'mesoderm development', 'monocyte differentiation', 'motor neuron migration', 'negative regulation of adherens junction organization', 'negative regulation of apoptotic process', 'negative regulation of blood-brain barrier permeability', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of establishment of endothelial barrier', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'outflow tract morphogenesis', 'ovarian follicle development', 'positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell migration by vascular endothelial growth factor signaling pathway', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway', 'positive regulation of cold-induced thermogenesis', 'positive regulation of CREB transcription factor activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of histone deacetylase activity', 'positive regulation of leukocyte migration', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of neuroblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of positive chemotaxis', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C signaling', 'positive regulation of protein kinase D signaling', 'positive regulation of protein localization to early endosome', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor internalization', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of trophoblast cell migration', 'positive regulation of vascular permeability', 'post-embryonic camera-type eye development', 'primitive erythrocyte differentiation', 'regulation of cell shape', 'regulation of nitric oxide mediated signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of transcription by RNA polymerase II', 'response to hypoxia', 'sprouting angiogenesis', 'surfactant homeostasis', 'tube formation', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway']['activation of protein kinase activity', 'angiogenesis', 'artery morphogenesis', 'basophil chemotaxis', 'branching involved in blood vessel morphogenesis', 'camera-type eye morphogenesis', 'cardiac muscle cell development', 'cardiac vascular smooth muscle cell development', 'cell maturation', 'cell migration involved in sprouting angiogenesis', 'cellular response to hypoxia', 'cellular response to vascular endothelial growth factor stimulus', 'cellular stress response to acid chemical', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'coronary vein morphogenesis', 'dopaminergic neuron differentiation', 'endothelial cell chemotaxis', 'epithelial cell differentiation', 'eye photoreceptor cell development', 'heart morphogenesis', 'in utero embryonic development', 'induction of positive chemotaxis', 'kidney development', 'lactation', 'lung development', 'lymph vessel morphogenesis', 'macrophage differentiation', 'mammary gland alveolus development', 'mesoderm development', 'monocyte differentiation', 'motor neuron migration', 'negative regulation of adherens junction organization', 'negative regulation of apoptotic process', 'negative regulation of blood-brain barrier permeability', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of establishment of endothelial barrier', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'outflow tract morphogenesis', 'ovarian follicle development', 'positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell migration by vascular endothelial growth factor signaling pathway', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway', 'positive regulation of cold-induced thermogenesis', 'positive regulation of CREB transcription factor activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of histone deacetylase activity', 'positive regulation of leukocyte migration', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of neuroblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of positive chemotaxis', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C signaling', 'positive regulation of protein kinase D signaling', 'positive regulation of protein localization to early endosome', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor internalization', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of trophoblast cell migration', 'positive regulation of vascular permeability', 'post-embryonic camera-type eye development', 'primitive erythrocyte differentiation', 'regulation of cell shape', 'regulation of nitric oxide mediated signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of transcription by RNA polymerase II', 'response to hypoxia', 'sprouting angiogenesis', 'surfactant homeostasis', 'tube formation', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway']
Trypsin-3
105
Amyloid-beta precursor protein
300
9.1
95
0.12
P35030P05067['antimicrobial humoral response', 'digestion', 'endothelial cell migration', 'proteolysis', 'zymogen activation']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Complement C3
873
Complement C3
1511
9.0
64
0.17
P01024P01024['amyloid-beta clearance', 'cell surface receptor signaling pathway involved in cell-cell signaling', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'complement-mediated synapse pruning', 'fatty acid metabolic process', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'neuron remodeling', 'opsonization', 'oviduct epithelium development', 'positive regulation of activation of membrane attack complex', 'positive regulation of angiogenesis', 'positive regulation of apoptotic cell clearance', 'positive regulation of apoptotic process in another organism', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of glucose transmembrane transport', 'positive regulation of immune response', 'positive regulation of lipid storage', 'positive regulation of opsonization', 'positive regulation of phagocytosis', 'positive regulation of phagocytosis, engulfment', 'positive regulation of protein phosphorylation', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of type IIa hypersensitivity', 'positive regulation of vascular endothelial growth factor production', 'proteolysis', 'regulation of complement activation', 'regulation of complement activation, alternative pathway', 'regulation of triglyceride biosynthetic process', 'response to bacterium', 'signal transduction', 'vertebrate eye-specific patterning']['amyloid-beta clearance', 'cell surface receptor signaling pathway involved in cell-cell signaling', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'complement-mediated synapse pruning', 'fatty acid metabolic process', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'neuron remodeling', 'opsonization', 'oviduct epithelium development', 'positive regulation of activation of membrane attack complex', 'positive regulation of angiogenesis', 'positive regulation of apoptotic cell clearance', 'positive regulation of apoptotic process in another organism', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of glucose transmembrane transport', 'positive regulation of immune response', 'positive regulation of lipid storage', 'positive regulation of opsonization', 'positive regulation of phagocytosis', 'positive regulation of phagocytosis, engulfment', 'positive regulation of protein phosphorylation', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of type IIa hypersensitivity', 'positive regulation of vascular endothelial growth factor production', 'proteolysis', 'regulation of complement activation', 'regulation of complement activation, alternative pathway', 'regulation of triglyceride biosynthetic process', 'response to bacterium', 'signal transduction', 'vertebrate eye-specific patterning']
Beta-nerve growth factor
189
Beta-nerve growth factor
231
9.8
95
0.11
P01138P01138['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'extrinsic apoptotic signaling pathway via death domain receptors', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of cell population proliferation', 'negative regulation of neuron apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of collateral sprouting', 'positive regulation of DNA binding', 'positive regulation of gene expression', 'positive regulation of neuron differentiation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of Ras protein signal transduction', 'regulation of neuron differentiation', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'extrinsic apoptotic signaling pathway via death domain receptors', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of cell population proliferation', 'negative regulation of neuron apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of collateral sprouting', 'positive regulation of DNA binding', 'positive regulation of gene expression', 'positive regulation of neuron differentiation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of Ras protein signal transduction', 'regulation of neuron differentiation', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Importin subunit beta-1
471
Zinc finger protein SNAI1
262
9.8
91
0.11
Q14974O95863['astral microtubule organization', 'establishment of mitotic spindle localization', 'establishment of protein localization', 'mitotic chromosome movement towards spindle pole', 'mitotic metaphase plate congression', 'mitotic spindle assembly', 'NLS-bearing protein import into nucleus', 'protein import into nucleus', 'Ran protein signal transduction', 'ribosomal protein import into nucleus', 'RNA import into nucleus']['aortic valve morphogenesis', 'cartilage morphogenesis', 'epithelial cell migration', 'epithelial to mesenchymal transition', 'epithelial to mesenchymal transition involved in endocardial cushion formation', 'hair follicle morphogenesis', 'heterochromatin organization', 'left/right pattern formation', 'mesoderm formation', 'negative regulation of cell differentiation involved in embryonic placenta development', 'negative regulation of DNA damage response, signal transduction by p53 class mediator', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of vitamin D biosynthetic process', 'Notch signaling involved in heart development', 'osteoblast differentiation', 'positive regulation of cell migration', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of transcription, DNA-templated', 'regulation of bicellular tight junction assembly', 'regulation of transcription by RNA polymerase II', 'roof of mouth development', 'trophoblast giant cell differentiation']
Neurotrophin-4
97
Neurotrophin-4
201
9.0
93
0.12
P34130P34130['adult locomotory behavior', 'epidermis development', 'ganglion mother cell fate determination', 'innervation', 'long-term memory', 'mechanoreceptor differentiation', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of peptidyl-serine phosphorylation', 'regulation of neuron differentiation', 'sensory organ boundary specification', 'taste bud development', 'transmembrane receptor protein tyrosine kinase signaling pathway']['adult locomotory behavior', 'epidermis development', 'ganglion mother cell fate determination', 'innervation', 'long-term memory', 'mechanoreceptor differentiation', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of peptidyl-serine phosphorylation', 'regulation of neuron differentiation', 'sensory organ boundary specification', 'taste bud development', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Cathepsin B
105
Cathepsin B
187
9.8
67
0.15
P07688P07688['cellular response to thyroid hormone stimulus', 'collagen catabolic process', 'decidualization', 'epithelial cell differentiation', 'negative regulation of peptidase activity', 'proteolysis involved in protein catabolic process', 'thyroid hormone generation', 'viral entry into host cell']['cellular response to thyroid hormone stimulus', 'collagen catabolic process', 'decidualization', 'epithelial cell differentiation', 'negative regulation of peptidase activity', 'proteolysis involved in protein catabolic process', 'thyroid hormone generation', 'viral entry into host cell']
Integrin beta-2
62
Integrin beta-2
447
9.0
76
0.15
P05107P05107['amyloid-beta clearance', 'apoptotic process', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-cell adhesion', 'cell-cell adhesion via plasma-membrane adhesion molecules', 'cell-cell signaling', 'cell-matrix adhesion', 'cellular response to low-density lipoprotein particle stimulus', 'endodermal cell differentiation', 'heterotypic cell-cell adhesion', 'inflammatory response', 'integrin-mediated signaling pathway', 'leukocyte cell-cell adhesion', 'microglial cell activation', 'negative regulation of dopamine metabolic process', 'neutrophil chemotaxis', 'neutrophil migration', 'phagocytosis, engulfment', 'positive regulation of leukocyte adhesion to vascular endothelial cell', 'positive regulation of neuron death', 'positive regulation of neutrophil degranulation', 'positive regulation of prostaglandin-E synthase activity', 'positive regulation of protein targeting to membrane', 'positive regulation of superoxide anion generation', 'receptor clustering', 'receptor internalization', 'receptor-mediated endocytosis', 'regulation of cell shape', 'regulation of peptidyl-tyrosine phosphorylation']['amyloid-beta clearance', 'apoptotic process', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-cell adhesion', 'cell-cell adhesion via plasma-membrane adhesion molecules', 'cell-cell signaling', 'cell-matrix adhesion', 'cellular response to low-density lipoprotein particle stimulus', 'endodermal cell differentiation', 'heterotypic cell-cell adhesion', 'inflammatory response', 'integrin-mediated signaling pathway', 'leukocyte cell-cell adhesion', 'microglial cell activation', 'negative regulation of dopamine metabolic process', 'neutrophil chemotaxis', 'neutrophil migration', 'phagocytosis, engulfment', 'positive regulation of leukocyte adhesion to vascular endothelial cell', 'positive regulation of neuron death', 'positive regulation of neutrophil degranulation', 'positive regulation of prostaglandin-E synthase activity', 'positive regulation of protein targeting to membrane', 'positive regulation of superoxide anion generation', 'receptor clustering', 'receptor internalization', 'receptor-mediated endocytosis', 'regulation of cell shape', 'regulation of peptidyl-tyrosine phosphorylation']
Beta-secretase 2
344
Beta-secretase 2
344
9.0
75
0.15
Q9Y5Z0Q9Y5Z0['amyloid-beta metabolic process', 'glucose homeostasis', 'membrane protein ectodomain proteolysis', 'negative regulation of amyloid precursor protein biosynthetic process', 'peptide hormone processing', 'proteolysis']['amyloid-beta metabolic process', 'glucose homeostasis', 'membrane protein ectodomain proteolysis', 'negative regulation of amyloid precursor protein biosynthetic process', 'peptide hormone processing', 'proteolysis']
Beta-arrestin-2
244
Beta-arrestin-2
244
9.0
65
0.17
P29067P29067['adult walking behavior', 'brain development', 'cell chemotaxis', 'desensitization of G protein-coupled receptor signaling pathway by arrestin', 'detection of temperature stimulus involved in sensory perception of pain', 'endocytosis', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor internalization', 'G protein-coupled receptor signaling pathway', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of GTPase activity', 'negative regulation of interleukin-1 beta production', 'negative regulation of interleukin-12 production', 'negative regulation of interleukin-6 production', 'negative regulation of natural killer cell mediated cytotoxicity', 'negative regulation of neuron apoptotic process', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of protein phosphorylation', 'negative regulation of protein ubiquitination', 'negative regulation of release of cytochrome c from mitochondria', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of toll-like receptor signaling pathway', 'negative regulation of tumor necrosis factor production', 'positive regulation of calcium ion transport', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of collagen biosynthetic process', 'positive regulation of DNA biosynthetic process', 'positive regulation of epithelial cell apoptotic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of receptor internalization', 'positive regulation of synaptic transmission, dopaminergic', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein transport', 'protein ubiquitination', 'receptor internalization', 'regulation of G protein-coupled receptor signaling pathway', 'regulation of protein phosphorylation', 'transcription by RNA polymerase II', 'transforming growth factor beta receptor signaling pathway']['adult walking behavior', 'brain development', 'cell chemotaxis', 'desensitization of G protein-coupled receptor signaling pathway by arrestin', 'detection of temperature stimulus involved in sensory perception of pain', 'endocytosis', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor internalization', 'G protein-coupled receptor signaling pathway', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of GTPase activity', 'negative regulation of interleukin-1 beta production', 'negative regulation of interleukin-12 production', 'negative regulation of interleukin-6 production', 'negative regulation of natural killer cell mediated cytotoxicity', 'negative regulation of neuron apoptotic process', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of protein phosphorylation', 'negative regulation of protein ubiquitination', 'negative regulation of release of cytochrome c from mitochondria', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of toll-like receptor signaling pathway', 'negative regulation of tumor necrosis factor production', 'positive regulation of calcium ion transport', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of collagen biosynthetic process', 'positive regulation of DNA biosynthetic process', 'positive regulation of epithelial cell apoptotic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of receptor internalization', 'positive regulation of synaptic transmission, dopaminergic', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein transport', 'protein ubiquitination', 'receptor internalization', 'regulation of G protein-coupled receptor signaling pathway', 'regulation of protein phosphorylation', 'transcription by RNA polymerase II', 'transforming growth factor beta receptor signaling pathway']
Peptidyl-tRNA hydrolase 2, mitochondrial
86
Peptidyl-tRNA hydrolase 2, mitochondrial
86
9.0
111
0.1
Q9Y3E5Q9Y3E5['apoptotic process', 'negative regulation of anoikis', 'negative regulation of gene expression', 'positive regulation of anoikis']['apoptotic process', 'negative regulation of anoikis', 'negative regulation of gene expression', 'positive regulation of anoikis']
Serine protease 1
220
Serine protease inhibitor Kazal-type 1
16
9.0
86
0.13
P00760P00998['digestion', 'proteolysis'][]
Urokinase plasminogen activator surface receptor
93
Urokinase plasminogen activator surface receptor
39
9.8
55
0.19
Q03405Q03405['blood coagulation', 'chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'negative regulation of intrinsic apoptotic signaling pathway', 'positive regulation of DNA binding', 'positive regulation of epidermal growth factor receptor signaling pathway', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of protein phosphorylation', 'positive regulation of release of cytochrome c from mitochondria', 'regulation of cell adhesion', 'regulation of fibrinolysis', 'regulation of plasminogen activation', 'regulation of proteolysis', 'signal transduction', 'urokinase plasminogen activator signaling pathway']['blood coagulation', 'chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'negative regulation of intrinsic apoptotic signaling pathway', 'positive regulation of DNA binding', 'positive regulation of epidermal growth factor receptor signaling pathway', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of protein phosphorylation', 'positive regulation of release of cytochrome c from mitochondria', 'regulation of cell adhesion', 'regulation of fibrinolysis', 'regulation of plasminogen activation', 'regulation of proteolysis', 'signal transduction', 'urokinase plasminogen activator signaling pathway']
Complement C3
873
Complement C3
1506
9.1
55
0.2
P01024P01024['amyloid-beta clearance', 'cell surface receptor signaling pathway involved in cell-cell signaling', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'complement-mediated synapse pruning', 'fatty acid metabolic process', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'neuron remodeling', 'opsonization', 'oviduct epithelium development', 'positive regulation of activation of membrane attack complex', 'positive regulation of angiogenesis', 'positive regulation of apoptotic cell clearance', 'positive regulation of apoptotic process in another organism', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of glucose transmembrane transport', 'positive regulation of immune response', 'positive regulation of lipid storage', 'positive regulation of opsonization', 'positive regulation of phagocytosis', 'positive regulation of phagocytosis, engulfment', 'positive regulation of protein phosphorylation', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of type IIa hypersensitivity', 'positive regulation of vascular endothelial growth factor production', 'proteolysis', 'regulation of complement activation', 'regulation of complement activation, alternative pathway', 'regulation of triglyceride biosynthetic process', 'response to bacterium', 'signal transduction', 'vertebrate eye-specific patterning']['amyloid-beta clearance', 'cell surface receptor signaling pathway involved in cell-cell signaling', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'complement-mediated synapse pruning', 'fatty acid metabolic process', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'neuron remodeling', 'opsonization', 'oviduct epithelium development', 'positive regulation of activation of membrane attack complex', 'positive regulation of angiogenesis', 'positive regulation of apoptotic cell clearance', 'positive regulation of apoptotic process in another organism', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of glucose transmembrane transport', 'positive regulation of immune response', 'positive regulation of lipid storage', 'positive regulation of opsonization', 'positive regulation of phagocytosis', 'positive regulation of phagocytosis, engulfment', 'positive regulation of protein phosphorylation', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of type IIa hypersensitivity', 'positive regulation of vascular endothelial growth factor production', 'proteolysis', 'regulation of complement activation', 'regulation of complement activation, alternative pathway', 'regulation of triglyceride biosynthetic process', 'response to bacterium', 'signal transduction', 'vertebrate eye-specific patterning']
Receptor activity-modifying protein 2
99
Receptor activity-modifying protein 2
99
9.8
64
0.16
O60895O60895['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adherens junction assembly', 'adrenomedullin receptor signaling pathway', 'amylin receptor signaling pathway', 'angiogenesis', 'basement membrane assembly', 'bicellular tight junction assembly', 'calcium ion transport', 'cellular response to hormone stimulus', 'cellular response to vascular endothelial growth factor stimulus', 'G protein-coupled receptor signaling pathway', 'heart development', 'intracellular protein transport', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of vascular permeability', 'positive regulation of angiogenesis', 'positive regulation of gene expression', 'positive regulation of vasculogenesis', 'protein localization to plasma membrane', 'protein transport', 'receptor internalization', 'regulation of blood pressure', 'regulation of G protein-coupled receptor signaling pathway', 'sprouting angiogenesis', 'vascular associated smooth muscle cell development', 'vasculogenesis']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adherens junction assembly', 'adrenomedullin receptor signaling pathway', 'amylin receptor signaling pathway', 'angiogenesis', 'basement membrane assembly', 'bicellular tight junction assembly', 'calcium ion transport', 'cellular response to hormone stimulus', 'cellular response to vascular endothelial growth factor stimulus', 'G protein-coupled receptor signaling pathway', 'heart development', 'intracellular protein transport', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of vascular permeability', 'positive regulation of angiogenesis', 'positive regulation of gene expression', 'positive regulation of vasculogenesis', 'protein localization to plasma membrane', 'protein transport', 'receptor internalization', 'regulation of blood pressure', 'regulation of G protein-coupled receptor signaling pathway', 'sprouting angiogenesis', 'vascular associated smooth muscle cell development', 'vasculogenesis']
Speckle-type POZ protein
184
Speckle-type POZ protein
184
9.1
48
0.23
O43791O43791['proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein polyubiquitination', 'regulation of proteolysis']['proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein polyubiquitination', 'regulation of proteolysis']
A disintegrin and metalloproteinase with thrombospondin motifs 5
371
A disintegrin and metalloproteinase with thrombospondin motifs 5
394
9.1
85
0.13
Q9UNA0Q9UNA0['defense response to bacterium', 'extracellular matrix disassembly', 'extracellular matrix organization', 'myoblast fusion', 'negative regulation of cold-induced thermogenesis', 'proteolysis', 'tooth eruption']['defense response to bacterium', 'extracellular matrix disassembly', 'extracellular matrix organization', 'myoblast fusion', 'negative regulation of cold-induced thermogenesis', 'proteolysis', 'tooth eruption']
Kunitz-type protease inhibitor 1
77
Suppressor of tumorigenicity 14 protein
641
9.1
100
0.11
H3BR01Q9Y5Y6[]['epithelial cell morphogenesis involved in placental branching', 'keratinocyte differentiation', 'neural tube closure', 'protein catabolic process', 'proteolysis']
Pyruvate carboxylase, mitochondrial
752
Pyruvate carboxylase, mitochondrial
816
9.1
88
0.13
P11498P11498['gluconeogenesis', 'lipid metabolic process', 'NADH metabolic process', 'NADP metabolic process', 'negative regulation of gene expression', 'positive regulation by host of viral process', 'pyruvate metabolic process', 'viral release from host cell', 'viral RNA genome packaging']['gluconeogenesis', 'lipid metabolic process', 'NADH metabolic process', 'NADP metabolic process', 'negative regulation of gene expression', 'positive regulation by host of viral process', 'pyruvate metabolic process', 'viral release from host cell', 'viral RNA genome packaging']
Kelch-like ECH-associated protein 1
434
Kelch-like ECH-associated protein 1
406
9.8
53
0.19
Q14145Q14145['cellular response to interleukin-4', 'cellular response to oxidative stress', 'cytoplasmic sequestering of transcription factor', 'in utero embryonic development', 'negative regulation of DNA-binding transcription factor activity', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'protein ubiquitination', 'regulation of autophagy', 'regulation of epidermal cell differentiation', 'ubiquitin-dependent protein catabolic process']['cellular response to interleukin-4', 'cellular response to oxidative stress', 'cytoplasmic sequestering of transcription factor', 'in utero embryonic development', 'negative regulation of DNA-binding transcription factor activity', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'protein ubiquitination', 'regulation of autophagy', 'regulation of epidermal cell differentiation', 'ubiquitin-dependent protein catabolic process']
Membrane cofactor protein
64
Membrane cofactor protein
64
9.1
79
0.14
P15529P15529['adaptive immune response', 'complement activation, classical pathway', 'innate immune response', 'negative regulation of complement activation, classical pathway', 'negative regulation of gene expression', 'positive regulation of gene expression', 'positive regulation of interleukin-10 production', 'positive regulation of memory T cell differentiation', 'positive regulation of regulatory T cell differentiation', 'positive regulation of T cell proliferation', 'positive regulation of transforming growth factor beta production', 'regulation of Notch signaling pathway', 'sequestering of extracellular ligand from receptor', 'single fertilization', 'T cell mediated immunity']['adaptive immune response', 'complement activation, classical pathway', 'innate immune response', 'negative regulation of complement activation, classical pathway', 'negative regulation of gene expression', 'positive regulation of gene expression', 'positive regulation of interleukin-10 production', 'positive regulation of memory T cell differentiation', 'positive regulation of regulatory T cell differentiation', 'positive regulation of T cell proliferation', 'positive regulation of transforming growth factor beta production', 'regulation of Notch signaling pathway', 'sequestering of extracellular ligand from receptor', 'single fertilization', 'T cell mediated immunity']
Transforming growth factor beta-2 proprotein
379
Transforming growth factor beta-2 proprotein
317
9.1
83
0.13
P61812P61812['activation of protein kinase activity', 'ascending aorta morphogenesis', 'atrial septum morphogenesis', 'atrial septum primum morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'cardiac epithelial to mesenchymal transition', 'cardiac muscle cell proliferation', 'cardiac right ventricle morphogenesis', 'cardioblast differentiation', 'cell death', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'collagen fibril organization', 'cranial skeletal system development', 'dopamine biosynthetic process', 'embryo development ending in birth or egg hatching', 'embryonic digestive tract development', 'embryonic limb morphogenesis', 'endocardial cushion fusion', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'extrinsic apoptotic signaling pathway', 'eye development', 'generation of neurons', 'glial cell migration', 'hair follicle development', 'hair follicle morphogenesis', 'heart development', 'heart morphogenesis', 'heart valve morphogenesis', 'hemopoiesis', 'inner ear development', 'kidney development', 'male gonad development', 'membranous septum morphogenesis', 'negative regulation of alkaline phosphatase activity', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'negative regulation of gene expression', 'negative regulation of macrophage cytokine production', 'negative regulation of Ras protein signal transduction', 'neural retina development', 'neural tube closure', 'neuron development', 'neutrophil chemotaxis', 'odontogenesis', 'outflow tract septum morphogenesis', 'pathway-restricted SMAD protein phosphorylation', 'pharyngeal arch artery morphogenesis', 'positive regulation of cardioblast differentiation', 'positive regulation of cell adhesion mediated by integrin', 'positive regulation of cell cycle', 'positive regulation of cell division', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'positive regulation of heart contraction', 'positive regulation of immune response', 'positive regulation of integrin biosynthetic process', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of Notch signaling pathway', 'positive regulation of ossification', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of stress-activated MAPK cascade', 'positive regulation of timing of catagen', 'protein phosphorylation', 'pulmonary valve morphogenesis', 'regulation of apoptotic process involved in outflow tract morphogenesis', 'regulation of cell population proliferation', 'regulation of timing of catagen', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to progesterone', 'response to wounding', 'response to xenobiotic stimulus', 'salivary gland morphogenesis', 'secondary palate development', 'skeletal system development', 'SMAD protein signal transduction', 'somatic stem cell division', 'substantia propria of cornea development', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'uterus development', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis', 'wound healing']['activation of protein kinase activity', 'ascending aorta morphogenesis', 'atrial septum morphogenesis', 'atrial septum primum morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'cardiac epithelial to mesenchymal transition', 'cardiac muscle cell proliferation', 'cardiac right ventricle morphogenesis', 'cardioblast differentiation', 'cell death', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'collagen fibril organization', 'cranial skeletal system development', 'dopamine biosynthetic process', 'embryo development ending in birth or egg hatching', 'embryonic digestive tract development', 'embryonic limb morphogenesis', 'endocardial cushion fusion', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'extrinsic apoptotic signaling pathway', 'eye development', 'generation of neurons', 'glial cell migration', 'hair follicle development', 'hair follicle morphogenesis', 'heart development', 'heart morphogenesis', 'heart valve morphogenesis', 'hemopoiesis', 'inner ear development', 'kidney development', 'male gonad development', 'membranous septum morphogenesis', 'negative regulation of alkaline phosphatase activity', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'negative regulation of gene expression', 'negative regulation of macrophage cytokine production', 'negative regulation of Ras protein signal transduction', 'neural retina development', 'neural tube closure', 'neuron development', 'neutrophil chemotaxis', 'odontogenesis', 'outflow tract septum morphogenesis', 'pathway-restricted SMAD protein phosphorylation', 'pharyngeal arch artery morphogenesis', 'positive regulation of cardioblast differentiation', 'positive regulation of cell adhesion mediated by integrin', 'positive regulation of cell cycle', 'positive regulation of cell division', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'positive regulation of heart contraction', 'positive regulation of immune response', 'positive regulation of integrin biosynthetic process', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of Notch signaling pathway', 'positive regulation of ossification', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of stress-activated MAPK cascade', 'positive regulation of timing of catagen', 'protein phosphorylation', 'pulmonary valve morphogenesis', 'regulation of apoptotic process involved in outflow tract morphogenesis', 'regulation of cell population proliferation', 'regulation of timing of catagen', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to progesterone', 'response to wounding', 'response to xenobiotic stimulus', 'salivary gland morphogenesis', 'secondary palate development', 'skeletal system development', 'SMAD protein signal transduction', 'somatic stem cell division', 'substantia propria of cornea development', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'uterus development', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis', 'wound healing']
Elafin
83
Elafin
83
9.1
77
0.14
P19957P19957['antibacterial humoral response', 'copulation', 'innate immune response', 'peptide cross-linking']['antibacterial humoral response', 'copulation', 'innate immune response', 'peptide cross-linking']
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
107
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
107
9.1
101
0.11
Q9H3H5Q9H3H5['dolichol metabolic process', 'dolichol-linked oligosaccharide biosynthetic process', 'protein N-linked glycosylation', 'UDP-N-acetylglucosamine metabolic process']['dolichol metabolic process', 'dolichol-linked oligosaccharide biosynthetic process', 'protein N-linked glycosylation', 'UDP-N-acetylglucosamine metabolic process']
Angiopoietin-related protein 2
443
Angiopoietin-related protein 2
430
9.8
86
0.12
Q9UKU9Q9UKU9['cell-cell signaling']['cell-cell signaling']
SPARC
130
SPARC
95
9.1
76
0.15
P09486P09486['anatomical structure development', 'negative regulation of angiogenesis', 'negative regulation of endothelial cell proliferation', 'positive regulation of endothelial cell migration', 'regulation of cell morphogenesis']['anatomical structure development', 'negative regulation of angiogenesis', 'negative regulation of endothelial cell proliferation', 'positive regulation of endothelial cell migration', 'regulation of cell morphogenesis']
Chymotrypsinogen A
42
Amyloid-beta precursor protein
300
9.1
100
0.11
P00766P05067['digestion', 'proteolysis']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Serine/threonine-protein kinase/endoribonuclease IRE1
605
Serine/threonine-protein kinase/endoribonuclease IRE1
605
9.8
60
0.17
O75460O75460['cellular response to glucose stimulus', 'cellular response to hydrogen peroxide', 'cellular response to unfolded protein', 'cellular response to vascular endothelial growth factor stimulus', 'endothelial cell proliferation', 'insulin metabolic process', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'IRE1-mediated unfolded protein response', 'mRNA catabolic process', 'mRNA cleavage', 'mRNA cleavage involved in mRNA processing', 'mRNA splicing, via endonucleolytic cleavage and ligation', 'peptidyl-serine autophosphorylation', 'peptidyl-serine trans-autophosphorylation', 'positive regulation of endoplasmic reticulum unfolded protein response', 'positive regulation of JUN kinase activity', 'positive regulation of RNA splicing', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of macroautophagy', 'response to endoplasmic reticulum stress']['cellular response to glucose stimulus', 'cellular response to hydrogen peroxide', 'cellular response to unfolded protein', 'cellular response to vascular endothelial growth factor stimulus', 'endothelial cell proliferation', 'insulin metabolic process', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'IRE1-mediated unfolded protein response', 'mRNA catabolic process', 'mRNA cleavage', 'mRNA cleavage involved in mRNA processing', 'mRNA splicing, via endonucleolytic cleavage and ligation', 'peptidyl-serine autophosphorylation', 'peptidyl-serine trans-autophosphorylation', 'positive regulation of endoplasmic reticulum unfolded protein response', 'positive regulation of JUN kinase activity', 'positive regulation of RNA splicing', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of macroautophagy', 'response to endoplasmic reticulum stress']
Fractalkine
74
Fractalkine
58
9.1
58
0.19
P78423P78423['aging', 'angiogenesis involved in wound healing', 'autocrine signaling', 'cell adhesion', 'cell chemotaxis', 'cell-cell adhesion', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'defense response', 'eosinophil chemotaxis', 'extrinsic apoptotic signaling pathway in absence of ligand', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'integrin activation', 'leukocyte adhesive activation', 'leukocyte chemotaxis', 'leukocyte migration involved in inflammatory response', 'lymphocyte chemotaxis', 'microglial cell activation', 'microglial cell proliferation', 'monocyte chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of apoptotic signaling pathway', 'negative regulation of cell migration', 'negative regulation of cell-substrate adhesion', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of glutamate receptor signaling pathway', 'negative regulation of hippocampal neuron apoptotic process', 'negative regulation of interleukin-1 alpha production', 'negative regulation of interleukin-1 beta production', 'negative regulation of interleukin-6 production', 'negative regulation of microglial cell activation', 'negative regulation of neuron migration', 'negative regulation of tumor necrosis factor production', 'neuron cellular homeostasis', 'neuron remodeling', 'neutrophil chemotaxis', 'positive chemotaxis', 'positive regulation of actin filament bundle assembly', 'positive regulation of calcium-independent cell-cell adhesion', 'positive regulation of cell population proliferation', 'positive regulation of cell-matrix adhesion', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of I-kappaB phosphorylation', 'positive regulation of inflammatory response', 'positive regulation of MAPK cascade', 'positive regulation of microglial cell migration', 'positive regulation of neuroblast proliferation', 'positive regulation of neuron projection development', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein kinase B signaling', 'positive regulation of release of sequestered calcium ion into cytosol', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transforming growth factor beta1 production', 'regulation of lipopolysaccharide-mediated signaling pathway', 'regulation of neurogenesis', 'regulation of synaptic plasticity', 'response to ischemia', 'synapse pruning']['aging', 'angiogenesis involved in wound healing', 'autocrine signaling', 'cell adhesion', 'cell chemotaxis', 'cell-cell adhesion', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'defense response', 'eosinophil chemotaxis', 'extrinsic apoptotic signaling pathway in absence of ligand', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'integrin activation', 'leukocyte adhesive activation', 'leukocyte chemotaxis', 'leukocyte migration involved in inflammatory response', 'lymphocyte chemotaxis', 'microglial cell activation', 'microglial cell proliferation', 'monocyte chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of apoptotic signaling pathway', 'negative regulation of cell migration', 'negative regulation of cell-substrate adhesion', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of glutamate receptor signaling pathway', 'negative regulation of hippocampal neuron apoptotic process', 'negative regulation of interleukin-1 alpha production', 'negative regulation of interleukin-1 beta production', 'negative regulation of interleukin-6 production', 'negative regulation of microglial cell activation', 'negative regulation of neuron migration', 'negative regulation of tumor necrosis factor production', 'neuron cellular homeostasis', 'neuron remodeling', 'neutrophil chemotaxis', 'positive chemotaxis', 'positive regulation of actin filament bundle assembly', 'positive regulation of calcium-independent cell-cell adhesion', 'positive regulation of cell population proliferation', 'positive regulation of cell-matrix adhesion', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of I-kappaB phosphorylation', 'positive regulation of inflammatory response', 'positive regulation of MAPK cascade', 'positive regulation of microglial cell migration', 'positive regulation of neuroblast proliferation', 'positive regulation of neuron projection development', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein kinase B signaling', 'positive regulation of release of sequestered calcium ion into cytosol', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transforming growth factor beta1 production', 'regulation of lipopolysaccharide-mediated signaling pathway', 'regulation of neurogenesis', 'regulation of synaptic plasticity', 'response to ischemia', 'synapse pruning']
Artemin
187
Artemin
154
9.1
62
0.18
Q5T4W7Q5T4W7['axon guidance', 'induction of positive chemotaxis', 'lymphocyte migration into lymphoid organs', 'neuroblast proliferation', 'peripheral nervous system development', "Peyer's patch morphogenesis", 'signal transduction']['axon guidance', 'induction of positive chemotaxis', 'lymphocyte migration into lymphoid organs', 'neuroblast proliferation', 'peripheral nervous system development', "Peyer's patch morphogenesis", 'signal transduction']
Serine protease 1
48
Pancreatic trypsin inhibitor
49
9.1
99
0.11
P07477P00974['digestion', 'extracellular matrix disassembly', 'proteolysis']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Fibrinogen alpha chain
68
Fibrinogen beta chain
95
9.1
65
0.17
P02671P02675['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']
Prostasin
86
Pancreatic trypsin inhibitor
73
9.8
85
0.12
Q16651P00974['positive regulation of sodium ion transport', 'proteolysis']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Protein Dok-7
45
Protein Dok-7
45
9.1
38
0.29
Q18PE0Q18PE0['neuromuscular junction development', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'protein phosphorylation', 'receptor clustering']['neuromuscular junction development', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'protein phosphorylation', 'receptor clustering']
Pyruvate kinase PKLR
74
Pyruvate kinase PKLR
360
9.1
77
0.14
O75758O75758['ATP biosynthetic process', 'cellular response to epinephrine stimulus', 'cellular response to insulin stimulus', 'glycolytic process', 'pyruvate biosynthetic process', 'response to ATP', 'response to cAMP', 'response to glucose', 'response to heat', 'response to hypoxia', 'response to lithium ion', 'response to nutrient']['ATP biosynthetic process', 'cellular response to epinephrine stimulus', 'cellular response to insulin stimulus', 'glycolytic process', 'pyruvate biosynthetic process', 'response to ATP', 'response to cAMP', 'response to glucose', 'response to heat', 'response to hypoxia', 'response to lithium ion', 'response to nutrient']
Epidermal growth factor receptor
231
Epidermal growth factor receptor
231
9.1
79
0.14
P00533P00533['activation of phospholipase C activity', 'cell differentiation', 'cell morphogenesis', 'cell surface receptor signaling pathway', 'cell-cell adhesion', 'cellular response to amino acid stimulus', 'cellular response to cadmium ion', 'cellular response to epidermal growth factor stimulus', 'cellular response to estradiol stimulus', 'cellular response to reactive oxygen species', 'cerebral cortex cell migration', 'digestive tract morphogenesis', 'embryonic placenta development', 'epidermal growth factor receptor signaling pathway', 'epithelial cell proliferation', 'ERBB2-EGFR signaling pathway', 'eyelid development in camera-type eye', 'hair follicle development', 'learning or memory', 'morphogenesis of an epithelial fold', 'negative regulation of apoptotic process', 'negative regulation of cardiocyte differentiation', 'negative regulation of epidermal growth factor receptor signaling pathway', 'negative regulation of protein catabolic process', 'ossification', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cyclin-dependent protein serine/threonine kinase activity', 'positive regulation of DNA repair', 'positive regulation of DNA replication', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of G1/S transition of mitotic cell cycle', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of miRNA maturation', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C activity', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein insertion into membrane', 'regulation of ERK1 and ERK2 cascade', 'regulation of JNK cascade', 'regulation of nitric-oxide synthase activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of phosphatidylinositol 3-kinase signaling', 'response to UV-A', 'salivary gland morphogenesis', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of phospholipase C activity', 'cell differentiation', 'cell morphogenesis', 'cell surface receptor signaling pathway', 'cell-cell adhesion', 'cellular response to amino acid stimulus', 'cellular response to cadmium ion', 'cellular response to epidermal growth factor stimulus', 'cellular response to estradiol stimulus', 'cellular response to reactive oxygen species', 'cerebral cortex cell migration', 'digestive tract morphogenesis', 'embryonic placenta development', 'epidermal growth factor receptor signaling pathway', 'epithelial cell proliferation', 'ERBB2-EGFR signaling pathway', 'eyelid development in camera-type eye', 'hair follicle development', 'learning or memory', 'morphogenesis of an epithelial fold', 'negative regulation of apoptotic process', 'negative regulation of cardiocyte differentiation', 'negative regulation of epidermal growth factor receptor signaling pathway', 'negative regulation of protein catabolic process', 'ossification', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cyclin-dependent protein serine/threonine kinase activity', 'positive regulation of DNA repair', 'positive regulation of DNA replication', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of G1/S transition of mitotic cell cycle', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of miRNA maturation', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C activity', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein insertion into membrane', 'regulation of ERK1 and ERK2 cascade', 'regulation of JNK cascade', 'regulation of nitric-oxide synthase activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of phosphatidylinositol 3-kinase signaling', 'response to UV-A', 'salivary gland morphogenesis', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Growth/differentiation factor 11
406
Growth/differentiation factor 11
371
9.8
81
0.13
O95390O95390['amacrine cell differentiation', 'camera-type eye morphogenesis', 'cell population proliferation', 'mesoderm development', 'metanephros development', 'negative regulation of amacrine cell differentiation', 'negative regulation of cell population proliferation', 'nervous system development', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'roof of mouth development', 'skeletal system development', 'SMAD protein signal transduction', 'spinal cord anterior/posterior patterning', 'type B pancreatic cell maturation', 'ureteric bud development']['amacrine cell differentiation', 'camera-type eye morphogenesis', 'cell population proliferation', 'mesoderm development', 'metanephros development', 'negative regulation of amacrine cell differentiation', 'negative regulation of cell population proliferation', 'nervous system development', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'roof of mouth development', 'skeletal system development', 'SMAD protein signal transduction', 'spinal cord anterior/posterior patterning', 'type B pancreatic cell maturation', 'ureteric bud development']
Sequestosome-1
131
Sequestosome-1
145
9.1
65
0.17
Q13501Q13501['aggrephagy', 'apoptotic process', 'autophagy', 'autophagy of mitochondrion', 'brown fat cell proliferation', 'cell differentiation', 'endosomal transport', 'endosome organization', 'energy homeostasis', 'immune system process', 'intracellular signal transduction', 'macroautophagy', 'mitophagy', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of apoptotic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'protein import into nucleus', 'protein localization', 'protein localization to perinuclear region of cytoplasm', 'protein phosphorylation', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of mitochondrion organization', 'regulation of protein complex stability', 'regulation of Ras protein signal transduction', 'response to ischemia', 'response to mitochondrial depolarisation', 'selective autophagy', 'temperature homeostasis', 'transcription by RNA polymerase II', 'ubiquitin-dependent protein catabolic process']['aggrephagy', 'apoptotic process', 'autophagy', 'autophagy of mitochondrion', 'brown fat cell proliferation', 'cell differentiation', 'endosomal transport', 'endosome organization', 'energy homeostasis', 'immune system process', 'intracellular signal transduction', 'macroautophagy', 'mitophagy', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of apoptotic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'protein import into nucleus', 'protein localization', 'protein localization to perinuclear region of cytoplasm', 'protein phosphorylation', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of mitochondrion organization', 'regulation of protein complex stability', 'regulation of Ras protein signal transduction', 'response to ischemia', 'response to mitochondrial depolarisation', 'selective autophagy', 'temperature homeostasis', 'transcription by RNA polymerase II', 'ubiquitin-dependent protein catabolic process']
Proprotein convertase subtilisin/kexin type 9
378
Low-density lipoprotein receptor
325
9.8
71
0.14
Q8NBP7Q59FQ1['apoptotic process', 'cellular response to insulin stimulus', 'cellular response to starvation', 'cholesterol homeostasis', 'cholesterol metabolic process', 'kidney development', 'lipoprotein metabolic process', 'liver development', 'low-density lipoprotein particle receptor catabolic process', 'lysosomal transport', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of low-density lipoprotein particle receptor binding', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of receptor internalization', 'negative regulation of receptor recycling', 'negative regulation of receptor-mediated endocytosis involved in cholesterol transport', 'negative regulation of sodium ion transmembrane transporter activity', 'neurogenesis', 'neuron differentiation', 'phospholipid metabolic process', 'positive regulation of low-density lipoprotein particle receptor catabolic process', 'positive regulation of neuron apoptotic process', 'positive regulation of receptor internalization', 'protein autoprocessing', 'regulation of neuron apoptotic process', 'regulation of signaling receptor activity', 'triglyceride metabolic process']['amyloid-beta clearance', 'amyloid-beta clearance by cellular catabolic process', 'artery morphogenesis', 'cellular response to fatty acid', 'cellular response to low-density lipoprotein particle stimulus', 'cholesterol homeostasis', 'cholesterol import', 'cholesterol metabolic process', 'cholesterol transport', 'endocytosis', 'high-density lipoprotein particle clearance', 'intestinal cholesterol absorption', 'lipid metabolic process', 'lipoprotein catabolic process', 'long-term memory', 'low-density lipoprotein particle clearance', 'negative regulation of amyloid fibril formation', 'negative regulation of astrocyte activation', 'negative regulation of gene expression', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of microglial cell activation', 'negative regulation of protein metabolic process', 'negative regulation of receptor recycling', 'phagocytosis', 'phospholipid transport', 'plasma lipoprotein particle clearance', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of lysosomal protein catabolic process', 'positive regulation of triglyceride biosynthetic process', 'receptor-mediated endocytosis', 'receptor-mediated endocytosis involved in cholesterol transport', 'regulation of cholesterol metabolic process', 'regulation of phosphatidylcholine catabolic process', 'regulation of protein metabolic process', 'response to caloric restriction']
Caspase-2
436
Caspase-2
366
9.1
80
0.14
P42575P42575['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'aging', 'apoptotic process', 'apoptotic signaling pathway', 'brain development', 'cellular response to DNA damage stimulus', 'cellular response to mechanical stimulus', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'ectopic germ cell programmed cell death', 'execution phase of apoptosis', 'extrinsic apoptotic signaling pathway in absence of ligand', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'luteolysis', 'negative regulation of apoptotic process', 'negative regulation of necroptotic process', 'neural retina development', 'positive regulation of apoptotic process', 'positive regulation of apoptotic signaling pathway', 'positive regulation of neuron apoptotic process', 'protein processing', 'release of cytochrome c from mitochondria']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'aging', 'apoptotic process', 'apoptotic signaling pathway', 'brain development', 'cellular response to DNA damage stimulus', 'cellular response to mechanical stimulus', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'ectopic germ cell programmed cell death', 'execution phase of apoptosis', 'extrinsic apoptotic signaling pathway in absence of ligand', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'luteolysis', 'negative regulation of apoptotic process', 'negative regulation of necroptotic process', 'neural retina development', 'positive regulation of apoptotic process', 'positive regulation of apoptotic signaling pathway', 'positive regulation of neuron apoptotic process', 'protein processing', 'release of cytochrome c from mitochondria']
Hemoglobin subunit alpha
105
Hemoglobin subunit delta
113
9.1
84
0.13
P69905P02042['carbon dioxide transport', 'cellular oxidant detoxification', 'hydrogen peroxide catabolic process', 'nitric oxide transport', 'oxygen transport', 'positive regulation of cell death', 'response to hydrogen peroxide']['carbon dioxide transport', 'cellular oxidant detoxification', 'hydrogen peroxide catabolic process', 'oxygen transport', 'positive regulation of cell death']
Transforming growth factor beta-3 proprotein
411
Transforming growth factor beta-3 proprotein
377
9.1
89
0.12
P10600P10600['aging', 'BMP signaling pathway', 'cell-cell junction organization', 'detection of hypoxia', 'digestive tract development', 'embryonic neurocranium morphogenesis', 'face morphogenesis', 'female pregnancy', 'frontal suture morphogenesis', 'in utero embryonic development', 'inner ear development', 'lung alveolus development', 'mammary gland development', 'negative regulation of cell population proliferation', 'negative regulation of macrophage cytokine production', 'negative regulation of neuron apoptotic process', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of vascular associated smooth muscle cell proliferation', 'odontogenesis', 'ossification involved in bone remodeling', 'positive regulation of apoptotic process', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of filopodium assembly', 'positive regulation of MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stress fiber assembly', 'positive regulation of tight junction disassembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of cell population proliferation', 'response to estrogen', 'response to hypoxia', 'response to laminar fluid shear stress', 'response to progesterone', 'salivary gland morphogenesis', 'secondary palate development', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'wound healing']['aging', 'BMP signaling pathway', 'cell-cell junction organization', 'detection of hypoxia', 'digestive tract development', 'embryonic neurocranium morphogenesis', 'face morphogenesis', 'female pregnancy', 'frontal suture morphogenesis', 'in utero embryonic development', 'inner ear development', 'lung alveolus development', 'mammary gland development', 'negative regulation of cell population proliferation', 'negative regulation of macrophage cytokine production', 'negative regulation of neuron apoptotic process', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of vascular associated smooth muscle cell proliferation', 'odontogenesis', 'ossification involved in bone remodeling', 'positive regulation of apoptotic process', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of filopodium assembly', 'positive regulation of MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stress fiber assembly', 'positive regulation of tight junction disassembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of cell population proliferation', 'response to estrogen', 'response to hypoxia', 'response to laminar fluid shear stress', 'response to progesterone', 'salivary gland morphogenesis', 'secondary palate development', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'wound healing']
Resistin
67
Resistin
55
9.8
66
0.15
Q99P87Q99P87['fat cell differentiation', 'negative regulation of feeding behavior', 'positive regulation of collagen metabolic process', 'positive regulation of progesterone secretion', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of synaptic transmission', 'response to insulin']['fat cell differentiation', 'negative regulation of feeding behavior', 'positive regulation of collagen metabolic process', 'positive regulation of progesterone secretion', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of synaptic transmission', 'response to insulin']
Neurturin
164
Neurturin
134
9.1
60
0.18
Q99748Q99748['MAPK cascade', 'nerve development', 'nervous system development', 'neural crest cell migration', 'neuron projection development', 'transmembrane receptor protein tyrosine kinase signaling pathway']['MAPK cascade', 'nerve development', 'nervous system development', 'neural crest cell migration', 'neuron projection development', 'transmembrane receptor protein tyrosine kinase signaling pathway']
GTP-binding protein REM 1
213
GTP-binding protein REM 1
213
9.1
88
0.13
O75628O75628['negative regulation of high voltage-gated calcium channel activity']['negative regulation of high voltage-gated calcium channel activity']
WD repeat-containing protein 48
366
Ubiquitin carboxyl-terminal hydrolase 46
233
9.8
67
0.15
Q8TAF3P62068['cellular response to DNA damage stimulus', 'double-strand break repair via homologous recombination', 'embryonic organ development', 'homeostasis of number of cells', 'multicellular organism growth', 'positive regulation of double-strand break repair via homologous recombination', 'positive regulation of epithelial cell proliferation', 'protein deubiquitination', 'regulation of protein monoubiquitination', 'seminiferous tubule development', 'single fertilization', 'skeletal system morphogenesis', 'skin development', 'spermatogenesis']['adult feeding behavior', 'behavioral fear response', 'behavioral response to ethanol', 'protein deubiquitination', 'regulation of synaptic transmission, GABAergic', 'righting reflex', 'ubiquitin-dependent protein catabolic process']
Glutamate receptor ionotropic, kainate 5
83
Glutamate receptor ionotropic, kainate 2
347
9.1
58
0.19
Q63273P42260['cellular response to glucose stimulus', 'chemical synaptic transmission', 'establishment of localization in cell', 'excitatory postsynaptic potential', 'modulation of chemical synaptic transmission', 'positive regulation of neuron apoptotic process', 'protein retention in ER lumen', 'receptor clustering', 'regulation of membrane potential', 'regulation of synaptic vesicle fusion to presynaptic active zone membrane', 'synaptic transmission, glutamatergic']['behavioral fear response', 'cellular calcium ion homeostasis', 'chemical synaptic transmission', 'detection of cold stimulus involved in thermoception', 'excitatory postsynaptic potential', 'inhibitory postsynaptic potential', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of synaptic transmission, glutamatergic', 'neuron apoptotic process', 'neuronal action potential', 'positive regulation of neuron apoptotic process', 'positive regulation of synaptic transmission', 'presynaptic modulation of chemical synaptic transmission', 'receptor clustering', 'regulation of JNK cascade', 'regulation of long-term neuronal synaptic plasticity', 'regulation of membrane potential', 'regulation of short-term neuronal synaptic plasticity', 'synaptic transmission, glutamatergic']
Gremlin-2
101
Gremlin-2
101
9.1
89
0.12
O88273O88273['animal organ morphogenesis', 'cytokine-mediated signaling pathway', 'determination of dorsal identity', 'embryonic body morphogenesis', 'negative regulation of BMP signaling pathway', 'regulation of cytokine activity', 'sequestering of BMP from receptor via BMP binding']['animal organ morphogenesis', 'cytokine-mediated signaling pathway', 'determination of dorsal identity', 'embryonic body morphogenesis', 'negative regulation of BMP signaling pathway', 'regulation of cytokine activity', 'sequestering of BMP from receptor via BMP binding']
Mismatch repair endonuclease PMS2
216
Mismatch repair endonuclease PMS2
216
9.1
95
0.12
P54278P54278['mismatch repair', 'response to xenobiotic stimulus', 'somatic hypermutation of immunoglobulin genes']['mismatch repair', 'response to xenobiotic stimulus', 'somatic hypermutation of immunoglobulin genes']
Glycoprotein hormones alpha chain
111
Follitropin subunit beta
105
9.1
78
0.14
Q96QJ4P01225[]['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
E3 ubiquitin/ISG15 ligase TRIM25
511
E3 ubiquitin/ISG15 ligase TRIM25
588
9.1
72
0.15
Q61510Q61510['cellular response to leukemia inhibitory factor', 'innate immune response', 'negative regulation of viral entry into host cell', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'protein monoubiquitination', 'regulation of protein localization', 'regulation of viral entry into host cell', 'response to estrogen', 'response to vitamin D', 'suppression of viral release by host', 'ubiquitin-dependent ERAD pathway', 'ubiquitin-dependent protein catabolic process', 'viral release from host cell']['cellular response to leukemia inhibitory factor', 'innate immune response', 'negative regulation of viral entry into host cell', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'protein monoubiquitination', 'regulation of protein localization', 'regulation of viral entry into host cell', 'response to estrogen', 'response to vitamin D', 'suppression of viral release by host', 'ubiquitin-dependent ERAD pathway', 'ubiquitin-dependent protein catabolic process', 'viral release from host cell']
Transforming growth factor beta-1 proprotein
223
Transforming growth factor beta-1 proprotein
223
9.1
63
0.17
P01137P01137['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']
Hemoglobin subunit alpha
105
Hemoglobin subunit beta
113
9.1
86
0.13
P69905A0A481SHK9['carbon dioxide transport', 'cellular oxidant detoxification', 'hydrogen peroxide catabolic process', 'nitric oxide transport', 'oxygen transport', 'positive regulation of cell death', 'response to hydrogen peroxide'][]
Transforming growth factor beta-1 proprotein
355
Transforming growth factor beta-1 proprotein
322
9.6
91
0.11
P01137P01137['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']
C-C motif chemokine 17
34
C-C motif chemokine 17
57
9.5
60
0.18
Q92583Q92583['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation of myoblast differentiation', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation of myoblast differentiation', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']
Pantothenate kinase 2, mitochondrial
508
Pantothenate kinase 2, mitochondrial
508
9.6
77
0.13
Q9BZ23Q9BZ23['aerobic respiration', 'angiogenesis', 'coenzyme A biosynthetic process', 'mitochondrion morphogenesis', 'pantothenate metabolic process', 'phosphorylation', 'regulation of bile acid metabolic process', 'regulation of fatty acid metabolic process', 'regulation of mitochondrial membrane potential', 'regulation of triglyceride metabolic process', 'spermatid development']['aerobic respiration', 'angiogenesis', 'coenzyme A biosynthetic process', 'mitochondrion morphogenesis', 'pantothenate metabolic process', 'phosphorylation', 'regulation of bile acid metabolic process', 'regulation of fatty acid metabolic process', 'regulation of mitochondrial membrane potential', 'regulation of triglyceride metabolic process', 'spermatid development']
Defensin-6
88
Defensin-6
74
9.5
60
0.18
Q01524Q01524['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism']
Ribonuclease pancreatic
93
Ribonuclease inhibitor
409
9.5
65
0.16
P07998P13489['defense response to Gram-positive bacterium', 'RNA phosphodiester bond hydrolysis']['mRNA catabolic process', 'regulation of angiogenesis']
Platelet factor 4
43
Platelet factor 4
43
9.5
78
0.14
P02776P02776['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'defense response to protozoan', 'inflammatory response', 'killing by host of symbiont cells', 'killing of cells of another organism', 'leukocyte chemotaxis', 'negative regulation of angiogenesis', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of megakaryocyte differentiation', 'negative regulation of MHC class II biosynthetic process', 'neutrophil chemotaxis', 'platelet activation', 'positive regulation of gene expression', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of macrophage differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'regulation of cell population proliferation']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'defense response to protozoan', 'inflammatory response', 'killing by host of symbiont cells', 'killing of cells of another organism', 'leukocyte chemotaxis', 'negative regulation of angiogenesis', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of megakaryocyte differentiation', 'negative regulation of MHC class II biosynthetic process', 'neutrophil chemotaxis', 'platelet activation', 'positive regulation of gene expression', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of macrophage differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'regulation of cell population proliferation']
Dihydropyrimidinase-related protein 2
323
Dihydropyrimidinase-related protein 2
323
9.6
79
0.13
O08553O08553['axon guidance', 'brain development', 'cytoskeleton organization', 'endocytosis', 'positive regulation of glutamate secretion', 'regulation of axon extension', 'regulation of neuron differentiation', 'regulation of neuron projection development', 'synaptic vesicle transport']['axon guidance', 'brain development', 'cytoskeleton organization', 'endocytosis', 'positive regulation of glutamate secretion', 'regulation of axon extension', 'regulation of neuron differentiation', 'regulation of neuron projection development', 'synaptic vesicle transport']
Ferritin
180
Ferritin
180
9.5
76
0.14
Q6NS36Q6NS36['cellular iron ion homeostasis', 'iron ion transport']['cellular iron ion homeostasis', 'iron ion transport']
Glycoprotein hormones alpha chain
111
Follitropin subunit beta
105
9.5
74
0.14
P01215P01225['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Cytochrome P450 2D6
57
Cytochrome P450 2D6
57
9.6
52
0.2
P10635P10635['alkaloid catabolic process', 'alkaloid metabolic process', 'arachidonic acid metabolic process', 'cholesterol metabolic process', 'coumarin metabolic process', 'estrogen metabolic process', 'heterocycle metabolic process', 'isoquinoline alkaloid metabolic process', 'long-chain fatty acid biosynthetic process', 'monoterpenoid metabolic process', 'negative regulation of binding', 'negative regulation of cellular organofluorine metabolic process', 'organic acid metabolic process', 'oxidative demethylation', 'retinol metabolic process', 'steroid metabolic process', 'xenobiotic catabolic process', 'xenobiotic metabolic process']['alkaloid catabolic process', 'alkaloid metabolic process', 'arachidonic acid metabolic process', 'cholesterol metabolic process', 'coumarin metabolic process', 'estrogen metabolic process', 'heterocycle metabolic process', 'isoquinoline alkaloid metabolic process', 'long-chain fatty acid biosynthetic process', 'monoterpenoid metabolic process', 'negative regulation of binding', 'negative regulation of cellular organofluorine metabolic process', 'organic acid metabolic process', 'oxidative demethylation', 'retinol metabolic process', 'steroid metabolic process', 'xenobiotic catabolic process', 'xenobiotic metabolic process']
Alcohol dehydrogenase 1A
101
Alcohol dehydrogenase 1A
287
9.6
66
0.16
P07327P07327['alcohol metabolic process', 'ethanol oxidation', 'retinoic acid metabolic process', 'retinol metabolic process']['alcohol metabolic process', 'ethanol oxidation', 'retinoic acid metabolic process', 'retinol metabolic process']
TNF receptor-associated factor 2
287
TNF receptor-associated factor 2
287
9.6
61
0.17
Q12933Q12933['activation of NF-kappaB-inducing kinase activity', 'cellular response to nitric oxide', 'interleukin-17-mediated signaling pathway', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'mRNA stabilization', 'negative regulation of glial cell apoptotic process', 'negative regulation of neuron death', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of I-kappaB phosphorylation', 'positive regulation of interleukin-2 production', 'positive regulation of JNK cascade', 'positive regulation of JUN kinase activity', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of T cell cytokine production', 'positive regulation of tumor necrosis factor-mediated signaling pathway', 'programmed necrotic cell death', 'protein autoubiquitination', 'protein catabolic process', 'protein K63-linked ubiquitination', 'protein-containing complex assembly', 'regulation of apoptotic process', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of immunoglobulin production', 'regulation of protein-containing complex assembly', 'response to endoplasmic reticulum stress', 'signal transduction', 'signal transduction involved in regulation of gene expression', 'tumor necrosis factor-mediated signaling pathway']['activation of NF-kappaB-inducing kinase activity', 'cellular response to nitric oxide', 'interleukin-17-mediated signaling pathway', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'mRNA stabilization', 'negative regulation of glial cell apoptotic process', 'negative regulation of neuron death', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of I-kappaB phosphorylation', 'positive regulation of interleukin-2 production', 'positive regulation of JNK cascade', 'positive regulation of JUN kinase activity', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of T cell cytokine production', 'positive regulation of tumor necrosis factor-mediated signaling pathway', 'programmed necrotic cell death', 'protein autoubiquitination', 'protein catabolic process', 'protein K63-linked ubiquitination', 'protein-containing complex assembly', 'regulation of apoptotic process', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of immunoglobulin production', 'regulation of protein-containing complex assembly', 'response to endoplasmic reticulum stress', 'signal transduction', 'signal transduction involved in regulation of gene expression', 'tumor necrosis factor-mediated signaling pathway']
C-C motif chemokine 17
33
C-C motif chemokine 17
57
9.6
64
0.16
Q92583Q92583['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation of myoblast differentiation', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation of myoblast differentiation', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']
Tumor necrosis factor ligand superfamily member 13
187
Tumor necrosis factor ligand superfamily member 13
202
9.6
94
0.11
Q9D777Q9D777['germinal center formation', 'immunoglobulin mediated immune response', 'positive regulation of cell population proliferation', 'positive regulation of germinal center formation', 'positive regulation of isotype switching to IgA isotypes', 'regulation of immune response']['germinal center formation', 'immunoglobulin mediated immune response', 'positive regulation of cell population proliferation', 'positive regulation of germinal center formation', 'positive regulation of isotype switching to IgA isotypes', 'regulation of immune response']
Glucocorticoid receptor
463
Glucocorticoid receptor
473
9.5
65
0.16
P04150P04150['adrenal gland development', 'apoptotic process', 'cell cycle', 'cell division', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin organization', 'chromosome segregation', 'glucocorticoid metabolic process', 'intracellular steroid hormone receptor signaling pathway', 'mammary gland duct morphogenesis', 'maternal behavior', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'signal transduction']['adrenal gland development', 'apoptotic process', 'cell cycle', 'cell division', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin organization', 'chromosome segregation', 'glucocorticoid metabolic process', 'intracellular steroid hormone receptor signaling pathway', 'mammary gland duct morphogenesis', 'maternal behavior', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'signal transduction']
Resistin-like beta
76
Resistin-like beta
76
9.5
86
0.12
Q99P86Q99P86['response to bacterium']['response to bacterium']
Ragulator complex protein LAMTOR4
51
Ragulator complex protein LAMTOR4
51
9.6
98
0.11
Q0VGL1Q0VGL1['cellular response to amino acid stimulus', 'positive regulation of TOR signaling', 'protein localization to lysosome', 'regulation of catalytic activity', 'regulation of cell size', 'TORC1 signaling']['cellular response to amino acid stimulus', 'positive regulation of TOR signaling', 'protein localization to lysosome', 'regulation of catalytic activity', 'regulation of cell size', 'TORC1 signaling']
Fibrinogen alpha chain
184
Fibrinogen gamma chain
165
9.6
73
0.14
P02671Q53Y18['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
ATP synthase subunit s, mitochondrial
126
ATP synthase subunit s, mitochondrial
126
9.6
81
0.13
P22027P22027['ATP biosynthetic process', 'ion transport']['ATP biosynthetic process', 'ion transport']
Cubilin
81
Cubilin
81
9.4
65
0.16
O60494O60494['cholesterol metabolic process', 'cobalamin metabolic process', 'cobalamin transport', 'establishment of localization in cell', 'lipoprotein transport', 'receptor-mediated endocytosis', 'response to bacterium', 'tissue homeostasis']['cholesterol metabolic process', 'cobalamin metabolic process', 'cobalamin transport', 'establishment of localization in cell', 'lipoprotein transport', 'receptor-mediated endocytosis', 'response to bacterium', 'tissue homeostasis']
von Hippel-Lindau disease tumor suppressor
77
von Hippel-Lindau disease tumor suppressor
77
9.4
84
0.13
P40337P40337['cell morphogenesis', 'negative regulation of apoptotic process', 'negative regulation of cell population proliferation', 'negative regulation of gene expression', 'negative regulation of receptor signaling pathway via JAK-STAT', 'negative regulation of transcription elongation from RNA polymerase II promoter', 'negative regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of cell differentiation', 'positive regulation of transcription, DNA-templated', 'protein stabilization', 'protein ubiquitination', 'proteolysis', 'regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'regulation of transcription, DNA-templated']['cell morphogenesis', 'negative regulation of apoptotic process', 'negative regulation of cell population proliferation', 'negative regulation of gene expression', 'negative regulation of receptor signaling pathway via JAK-STAT', 'negative regulation of transcription elongation from RNA polymerase II promoter', 'negative regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of cell differentiation', 'positive regulation of transcription, DNA-templated', 'protein stabilization', 'protein ubiquitination', 'proteolysis', 'regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'regulation of transcription, DNA-templated']
Poly [ADP-ribose] polymerase
970
Poly [ADP-ribose] polymerase
970
9.4
66
0.16
Q59FX0Q59FX0['positive regulation of telomere maintenance via telomerase', 'spindle assembly', 'Wnt signaling pathway']['positive regulation of telomere maintenance via telomerase', 'spindle assembly', 'Wnt signaling pathway']
Growth/differentiation factor 8
340
Growth/differentiation factor 8
375
9.7
83
0.12
O08689O08689['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
Tumor necrosis factor ligand superfamily member 13B
232
Tumor necrosis factor ligand superfamily member 13B
232
9.7
90
0.11
Q9Y275Q9Y275['B cell costimulation', 'B cell differentiation', 'B cell homeostasis', 'B cell proliferation', 'germinal center formation', 'positive regulation of B cell proliferation', 'positive regulation of germinal center formation', 'positive regulation of T cell proliferation', 'signal transduction', 'T cell costimulation', 'T cell proliferation', 'tumor necrosis factor-mediated signaling pathway']['B cell costimulation', 'B cell differentiation', 'B cell homeostasis', 'B cell proliferation', 'germinal center formation', 'positive regulation of B cell proliferation', 'positive regulation of germinal center formation', 'positive regulation of T cell proliferation', 'signal transduction', 'T cell costimulation', 'T cell proliferation', 'tumor necrosis factor-mediated signaling pathway']
Vesicle-associated membrane protein 2
103
Syntaxin-1A
272
9.4
60
0.18
P63045P32851['calcium-ion regulated exocytosis', 'cellular response to insulin stimulus', 'eosinophil degranulation', 'exocytic insertion of neurotransmitter receptor to postsynaptic membrane', 'Golgi to plasma membrane protein transport', 'hormone secretion', 'long-term synaptic potentiation', 'membrane fusion', 'positive regulation of intracellular protein transport', 'protein transport', 'protein-containing complex assembly', 'regulated exocytosis', 'regulation of delayed rectifier potassium channel activity', 'regulation of exocytosis', 'regulation of synaptic vesicle recycling', 'regulation of vesicle-mediated transport', 'response to glucose', 'SNARE complex assembly', 'synaptic vesicle docking', 'synaptic vesicle endocytosis', 'synaptic vesicle exocytosis', 'vesicle fusion', 'vesicle-mediated transport']['calcium-ion regulated exocytosis', 'exocytosis', 'hormone secretion', 'insulin secretion', 'intracellular protein transport', 'modulation of excitatory postsynaptic potential', 'neurotransmitter transport', 'positive regulation of calcium ion-dependent exocytosis', 'positive regulation of catecholamine secretion', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of exocytosis', 'positive regulation of neurotransmitter secretion', 'positive regulation of norepinephrine secretion', 'protein localization to membrane', 'protein sumoylation', 'regulated exocytosis', 'regulation of exocytosis', 'regulation of synaptic vesicle priming', 'response to gravity', 'secretion by cell', 'SNARE complex assembly', 'synaptic vesicle docking', 'synaptic vesicle endocytosis', 'synaptic vesicle exocytosis', 'synaptic vesicle fusion to presynaptic active zone membrane', 'vesicle docking', 'vesicle fusion']
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
624
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
624
9.7
70
0.15
Q8CIH5Q8CIH5['activation of store-operated calcium channel activity', 'antifungal innate immune response', 'B cell differentiation', 'B cell receptor signaling pathway', 'calcium-mediated signaling', 'cell activation', 'cellular response to calcium ion', 'cellular response to lectin', 'cellular response to lipid', 'follicular B cell differentiation', 'inositol trisphosphate biosynthetic process', 'intracellular signal transduction', 'lipopolysaccharide-mediated signaling pathway', 'macrophage activation involved in immune response', 'negative regulation of programmed cell death', 'phosphatidylinositol biosynthetic process', 'phospholipid catabolic process', 'positive regulation of calcium-mediated signaling', 'positive regulation of cell cycle G1/S phase transition', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of dendritic cell cytokine production', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of epithelial cell migration', 'positive regulation of gene expression', 'positive regulation of I-kappaB phosphorylation', 'positive regulation of interleukin-10 production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-2 production', 'positive regulation of interleukin-23 production', 'positive regulation of interleukin-6 production', 'positive regulation of macrophage cytokine production', 'positive regulation of MAPK cascade', 'positive regulation of neuroinflammatory response', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NLRP3 inflammasome complex assembly', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phagocytosis, engulfment', 'positive regulation of reactive oxygen species biosynthetic process', 'positive regulation of receptor internalization', 'positive regulation of tumor necrosis factor production', 'positive regulation of type I interferon production', 'programmed cell death', 'regulation of calcineurin-NFAT signaling cascade', 'regulation of gene expression', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of lipid metabolic process', 'release of sequestered calcium ion into cytosol', 'response to ATP', 'response to axon injury', 'response to lipopolysaccharide', 'response to magnesium ion', 'response to yeast', 'stimulatory C-type lectin receptor signaling pathway', 'T cell receptor signaling pathway', 'toll-like receptor signaling pathway']['activation of store-operated calcium channel activity', 'antifungal innate immune response', 'B cell differentiation', 'B cell receptor signaling pathway', 'calcium-mediated signaling', 'cell activation', 'cellular response to calcium ion', 'cellular response to lectin', 'cellular response to lipid', 'follicular B cell differentiation', 'inositol trisphosphate biosynthetic process', 'intracellular signal transduction', 'lipopolysaccharide-mediated signaling pathway', 'macrophage activation involved in immune response', 'negative regulation of programmed cell death', 'phosphatidylinositol biosynthetic process', 'phospholipid catabolic process', 'positive regulation of calcium-mediated signaling', 'positive regulation of cell cycle G1/S phase transition', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of dendritic cell cytokine production', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of epithelial cell migration', 'positive regulation of gene expression', 'positive regulation of I-kappaB phosphorylation', 'positive regulation of interleukin-10 production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-2 production', 'positive regulation of interleukin-23 production', 'positive regulation of interleukin-6 production', 'positive regulation of macrophage cytokine production', 'positive regulation of MAPK cascade', 'positive regulation of neuroinflammatory response', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NLRP3 inflammasome complex assembly', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phagocytosis, engulfment', 'positive regulation of reactive oxygen species biosynthetic process', 'positive regulation of receptor internalization', 'positive regulation of tumor necrosis factor production', 'positive regulation of type I interferon production', 'programmed cell death', 'regulation of calcineurin-NFAT signaling cascade', 'regulation of gene expression', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of lipid metabolic process', 'release of sequestered calcium ion into cytosol', 'response to ATP', 'response to axon injury', 'response to lipopolysaccharide', 'response to magnesium ion', 'response to yeast', 'stimulatory C-type lectin receptor signaling pathway', 'T cell receptor signaling pathway', 'toll-like receptor signaling pathway']
C-type lectin domain family 2 member D
91
C-type lectin domain family 2 member D
80
9.7
80
0.13
Q91V08Q91V08['cellular defense response', 'negative regulation of osteoclast differentiation', 'protection from natural killer cell mediated cytotoxicity']['cellular defense response', 'negative regulation of osteoclast differentiation', 'protection from natural killer cell mediated cytotoxicity']
E3 ubiquitin-protein ligase RNF13
278
E3 ubiquitin-protein ligase RNF13
243
9.7
68
0.15
O43567O43567['organelle localization', 'positive regulation of stress-activated protein kinase signaling cascade', 'protein autoubiquitination', 'ubiquitin-dependent protein catabolic process']['organelle localization', 'positive regulation of stress-activated protein kinase signaling cascade', 'protein autoubiquitination', 'ubiquitin-dependent protein catabolic process']
Glucocorticoid receptor
457
Glucocorticoid receptor
457
9.6
64
0.16
P79269P79269['cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'chromatin organization', 'positive regulation of transcription by RNA polymerase II']['cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'chromatin organization', 'positive regulation of transcription by RNA polymerase II']
Rhodopsin
140
Guanine nucleotide-binding protein G(t) subunit alpha-1
347
9.4
72
0.15
P02699P04695['absorption of visible light', 'cellular response to light stimulus', 'detection of temperature stimulus involved in thermoception', 'G protein-coupled receptor signaling pathway', 'photoreceptor cell maintenance', 'phototransduction', 'phototransduction, visible light', 'protein phosphorylation', 'response to light stimulus', 'retina development in camera-type eye', 'rhodopsin mediated signaling pathway', 'thermotaxis', 'visual perception']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell population proliferation', 'cellular response to electrical stimulus', 'detection of light stimulus involved in visual perception', 'eye photoreceptor cell development', 'G protein-coupled adenosine receptor signaling pathway', 'negative regulation of cyclic-nucleotide phosphodiesterase activity', 'phototransduction', 'phototransduction, visible light', 'response to light stimulus', 'retina development in camera-type eye', 'sensory perception of umami taste']
Vascular endothelial growth factor B
72
Vascular endothelial growth factor B
124
9.4
61
0.17
P49765P49765['cardiac muscle contraction', 'coronary vasculature development', 'induction of positive chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of gene expression', 'negative regulation of neuron apoptotic process', 'positive regulation of angiogenesis', 'positive regulation of cell division', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'positive regulation of vascular wound healing', 'protein O-linked glycosylation', 'response to hypoxia', 'sprouting angiogenesis', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor signaling pathway']['cardiac muscle contraction', 'coronary vasculature development', 'induction of positive chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of gene expression', 'negative regulation of neuron apoptotic process', 'positive regulation of angiogenesis', 'positive regulation of cell division', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'positive regulation of vascular wound healing', 'protein O-linked glycosylation', 'response to hypoxia', 'sprouting angiogenesis', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor signaling pathway']
Cytochrome P450 7A1
44
Cytochrome P450 7A1
44
9.4
88
0.12
P22680P22680['bile acid and bile salt transport', 'bile acid biosynthetic process', 'bile acid signaling pathway', 'cellular response to cholesterol', 'cellular response to glucose stimulus', 'cholesterol catabolic process', 'cholesterol homeostasis', 'negative regulation of collagen biosynthetic process', 'negative regulation of fatty acid biosynthetic process', 'positive regulation of cholesterol biosynthetic process', 'regulation of bile acid biosynthetic process', 'regulation of gene expression', 'response to ethanol', 'sterol metabolic process']['bile acid and bile salt transport', 'bile acid biosynthetic process', 'bile acid signaling pathway', 'cellular response to cholesterol', 'cellular response to glucose stimulus', 'cholesterol catabolic process', 'cholesterol homeostasis', 'negative regulation of collagen biosynthetic process', 'negative regulation of fatty acid biosynthetic process', 'positive regulation of cholesterol biosynthetic process', 'regulation of bile acid biosynthetic process', 'regulation of gene expression', 'response to ethanol', 'sterol metabolic process']
Glutamate receptor 2
78
Glutamate receptor 2
330
9.4
72
0.15
P19491P19491['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']
Acyloxyacyl hydrolase
113
Acyloxyacyl hydrolase
453
9.4
60
0.18
O18823O18823['fatty acid metabolic process', 'lipopolysaccharide catabolic process']['fatty acid metabolic process', 'lipopolysaccharide catabolic process']
Threonine aspartase 1
163
Threonine aspartase 1
293
9.4
89
0.12
Q9H6P5Q9H6P5['positive regulation of transcription, DNA-templated', 'protein maturation', 'proteolysis']['positive regulation of transcription, DNA-templated', 'protein maturation', 'proteolysis']
Bone morphogenetic protein 3
436
Bone morphogenetic protein 3
469
9.4
77
0.14
P12645P12645['cartilage development', 'cell-cell signaling', 'osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'skeletal system development', 'SMAD protein signal transduction']['cartilage development', 'cell-cell signaling', 'osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'skeletal system development', 'SMAD protein signal transduction']
Histone deacetylase 6
1186
Histone deacetylase 6
1120
9.6
73
0.14
Q9UBN7Q9UBN7['aggresome assembly', 'autophagy', 'axonal transport of mitochondrion', 'cellular response to hydrogen peroxide', 'cellular response to misfolded protein', 'cellular response to topologically incorrect protein', 'cilium assembly', 'cilium disassembly', 'collateral sprouting', 'dendritic spine morphogenesis', 'histone deacetylation', 'Hsp90 deacetylation', 'intracellular protein transport', 'lysosome localization', 'negative regulation of hydrogen peroxide metabolic process', 'negative regulation of microtubule depolymerization', 'negative regulation of oxidoreductase activity', 'negative regulation of protein-containing complex assembly', 'negative regulation of protein-containing complex disassembly', 'negative regulation of proteolysis', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization', 'peptidyl-lysine deacetylation', 'polyubiquitinated misfolded protein transport', 'positive regulation of epithelial cell migration', 'positive regulation of hydrogen peroxide-mediated programmed cell death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of signaling receptor activity', 'protein deacetylation', 'protein destabilization', 'protein polyubiquitination', 'protein quality control for misfolded or incompletely synthesized proteins', 'protein-containing complex disassembly', 'regulation of androgen receptor signaling pathway', 'regulation of autophagy', 'regulation of autophagy of mitochondrion', 'regulation of establishment of protein localization', 'regulation of fat cell differentiation', 'regulation of gene expression, epigenetic', 'regulation of macroautophagy', 'regulation of microtubule-based movement', 'regulation of protein stability', 'response to growth factor', 'response to misfolded protein', 'tubulin deacetylation', 'ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway']['aggresome assembly', 'autophagy', 'axonal transport of mitochondrion', 'cellular response to hydrogen peroxide', 'cellular response to misfolded protein', 'cellular response to topologically incorrect protein', 'cilium assembly', 'cilium disassembly', 'collateral sprouting', 'dendritic spine morphogenesis', 'histone deacetylation', 'Hsp90 deacetylation', 'intracellular protein transport', 'lysosome localization', 'negative regulation of hydrogen peroxide metabolic process', 'negative regulation of microtubule depolymerization', 'negative regulation of oxidoreductase activity', 'negative regulation of protein-containing complex assembly', 'negative regulation of protein-containing complex disassembly', 'negative regulation of proteolysis', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization', 'peptidyl-lysine deacetylation', 'polyubiquitinated misfolded protein transport', 'positive regulation of epithelial cell migration', 'positive regulation of hydrogen peroxide-mediated programmed cell death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of signaling receptor activity', 'protein deacetylation', 'protein destabilization', 'protein polyubiquitination', 'protein quality control for misfolded or incompletely synthesized proteins', 'protein-containing complex disassembly', 'regulation of androgen receptor signaling pathway', 'regulation of autophagy', 'regulation of autophagy of mitochondrion', 'regulation of establishment of protein localization', 'regulation of fat cell differentiation', 'regulation of gene expression, epigenetic', 'regulation of macroautophagy', 'regulation of microtubule-based movement', 'regulation of protein stability', 'response to growth factor', 'response to misfolded protein', 'tubulin deacetylation', 'ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway']
Hemoglobin subunit alpha
111
Hemoglobin subunit beta
112
9.0
79
0.14
P60529P60524['cellular oxidant detoxification', 'hydrogen peroxide catabolic process']['cellular oxidant detoxification', 'hydrogen peroxide catabolic process']
Growth/differentiation factor 8
339
Growth/differentiation factor 8
313
9.0
57
0.19
O14793O14793['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'muscle organ development', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'muscle organ development', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
Inhibin beta A chain
390
Inhibin beta A chain
354
9.6
68
0.15
P08476P08476['activin receptor signaling pathway', 'cell differentiation', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular response to cholesterol', 'cellular response to follicle-stimulating hormone stimulus', 'defense response', 'endodermal cell differentiation', 'erythrocyte differentiation', 'extrinsic apoptotic signaling pathway', 'eyelid development in camera-type eye', 'GABAergic neuron differentiation', 'hair follicle development', 'hematopoietic progenitor cell differentiation', 'hemoglobin biosynthetic process', 'male gonad development', 'mesodermal cell differentiation', 'multicellular organism aging', 'negative regulation of B cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of follicle-stimulating hormone secretion', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of interferon-gamma production', 'negative regulation of macrophage differentiation', 'negative regulation of phosphorylation', 'nervous system development', 'odontogenesis', 'ovarian follicle development', 'positive regulation of erythrocyte differentiation', 'positive regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'positive regulation of follicle-stimulating hormone secretion', 'positive regulation of gene expression', 'positive regulation of ovulation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein metabolic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'progesterone secretion', 'regulation of follicle-stimulating hormone secretion', 'regulation of transcription by RNA polymerase II', 'response to xenobiotic stimulus', 'roof of mouth development', 'SMAD protein signal transduction', 'striatal medium spiny neuron differentiation', 'transcription by RNA polymerase II']['activin receptor signaling pathway', 'cell differentiation', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular response to cholesterol', 'cellular response to follicle-stimulating hormone stimulus', 'defense response', 'endodermal cell differentiation', 'erythrocyte differentiation', 'extrinsic apoptotic signaling pathway', 'eyelid development in camera-type eye', 'GABAergic neuron differentiation', 'hair follicle development', 'hematopoietic progenitor cell differentiation', 'hemoglobin biosynthetic process', 'male gonad development', 'mesodermal cell differentiation', 'multicellular organism aging', 'negative regulation of B cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of follicle-stimulating hormone secretion', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of interferon-gamma production', 'negative regulation of macrophage differentiation', 'negative regulation of phosphorylation', 'nervous system development', 'odontogenesis', 'ovarian follicle development', 'positive regulation of erythrocyte differentiation', 'positive regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'positive regulation of follicle-stimulating hormone secretion', 'positive regulation of gene expression', 'positive regulation of ovulation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein metabolic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'progesterone secretion', 'regulation of follicle-stimulating hormone secretion', 'regulation of transcription by RNA polymerase II', 'response to xenobiotic stimulus', 'roof of mouth development', 'SMAD protein signal transduction', 'striatal medium spiny neuron differentiation', 'transcription by RNA polymerase II']
Glandular kallikrein
33
Pancreatic trypsin inhibitor
49
9.5
102
0.1
P00752P00974['regulation of systemic arterial blood pressure', 'zymogen activation']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
E3 ubiquitin-protein ligase Mdm2
478
E3 ubiquitin-protein ligase Mdm2
461
9.2
81
0.13
Q7YRZ8Q7YRZ8['apoptotic process', 'negative regulation of apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'protein ubiquitination', 'regulation of biological quality', 'regulation of cell cycle', 'regulation of transcription by RNA polymerase II']['apoptotic process', 'negative regulation of apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'protein ubiquitination', 'regulation of biological quality', 'regulation of cell cycle', 'regulation of transcription by RNA polymerase II']
Prorelaxin H2
171
Prorelaxin H2
35
9.0
59
0.19
P04090P04090['female pregnancy', 'positive regulation of angiogenesis', 'positive regulation of gene expression', 'regulation of catalytic activity']['female pregnancy', 'positive regulation of angiogenesis', 'positive regulation of gene expression', 'regulation of catalytic activity']
Tumor necrosis factor ligand superfamily member 13
187
Tumor necrosis factor ligand superfamily member 13
187
9.8
90
0.11
Q9D777Q9D777['germinal center formation', 'immunoglobulin mediated immune response', 'positive regulation of cell population proliferation', 'positive regulation of germinal center formation', 'positive regulation of isotype switching to IgA isotypes', 'regulation of immune response']['germinal center formation', 'immunoglobulin mediated immune response', 'positive regulation of cell population proliferation', 'positive regulation of germinal center formation', 'positive regulation of isotype switching to IgA isotypes', 'regulation of immune response']
Growth/differentiation factor 8
340
Growth/differentiation factor 8
310
9.8
82
0.12
O08689O08689['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
Claudin-3
19
Claudin-3
19
9.8
82
0.12
Q9Z0G9Q9Z0G9['actin cytoskeleton reorganization', 'bicellular tight junction assembly', 'calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules', 'cell adhesion', 'cell junction maintenance', 'epithelial cell morphogenesis', 'establishment of endothelial blood-brain barrier', 'negative regulation of cell migration', 'negative regulation of cell population proliferation', 'negative regulation of gene expression', 'negative regulation of wound healing', 'positive regulation of bicellular tight junction assembly', 'positive regulation of cell junction assembly', 'positive regulation of cell migration', 'positive regulation of gene expression', 'positive regulation of metallopeptidase activity', 'positive regulation of protein phosphorylation', 'positive regulation of wound healing', 'regulation of cell morphogenesis', 'regulation of membrane permeability', 'regulation of transepithelial transport', 'response to ethanol', 'response to Gram-positive bacterium', 'response to hypoxia']['actin cytoskeleton reorganization', 'bicellular tight junction assembly', 'calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules', 'cell adhesion', 'cell junction maintenance', 'epithelial cell morphogenesis', 'establishment of endothelial blood-brain barrier', 'negative regulation of cell migration', 'negative regulation of cell population proliferation', 'negative regulation of gene expression', 'negative regulation of wound healing', 'positive regulation of bicellular tight junction assembly', 'positive regulation of cell junction assembly', 'positive regulation of cell migration', 'positive regulation of gene expression', 'positive regulation of metallopeptidase activity', 'positive regulation of protein phosphorylation', 'positive regulation of wound healing', 'regulation of cell morphogenesis', 'regulation of membrane permeability', 'regulation of transepithelial transport', 'response to ethanol', 'response to Gram-positive bacterium', 'response to hypoxia']
Glycoprotein hormones alpha chain
111
Follitropin subunit beta
112
9.8
84
0.12
Q96QJ4P01225[]['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Dihydropyrimidine dehydrogenase [NADP(+)]
79
Dihydropyrimidine dehydrogenase [NADP(+)]
956
9.8
88
0.12
Q28943Q28943['beta-alanine biosynthetic process', 'thymidine catabolic process', 'thymine catabolic process', 'uracil catabolic process']['beta-alanine biosynthetic process', 'thymidine catabolic process', 'thymine catabolic process', 'uracil catabolic process']
Fibrinogen beta chain
83
Fibrinogen beta chain
83
9.8
84
0.12
P02676P02676['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'innate immune response', 'platelet aggregation', 'protein polymerization']['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'innate immune response', 'platelet aggregation', 'protein polymerization']
Beta-secretase 2
393
Beta-secretase 2
393
9.0
76
0.15
Q9Y5Z0Q9Y5Z0['amyloid-beta metabolic process', 'glucose homeostasis', 'membrane protein ectodomain proteolysis', 'negative regulation of amyloid precursor protein biosynthetic process', 'peptide hormone processing', 'proteolysis']['amyloid-beta metabolic process', 'glucose homeostasis', 'membrane protein ectodomain proteolysis', 'negative regulation of amyloid precursor protein biosynthetic process', 'peptide hormone processing', 'proteolysis']
Defensin beta 4A
53
Defensin beta 4A
53
9.0
90
0.12
O15263O15263['antifungal innate immune response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell chemotaxis', 'chemotaxis', 'defense response to bacterium', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'G protein-coupled receptor signaling pathway', 'immune response', 'killing of cells of another organism', 'membrane disruption in another organism']['antifungal innate immune response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell chemotaxis', 'chemotaxis', 'defense response to bacterium', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'G protein-coupled receptor signaling pathway', 'immune response', 'killing of cells of another organism', 'membrane disruption in another organism']
Glycoprotein hormones alpha chain
83
Follitropin subunit beta
105
9.5
77
0.14
P01215P01225['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Histone-lysine N-methyltransferase PRDM9
753
Histone-lysine N-methyltransferase PRDM9
557
9.5
42
0.25
Q9NQV7Q9NQV7['chromatin organization', 'double-strand break repair involved in meiotic recombination', 'female gamete generation', 'histone H3-K36 dimethylation', 'histone H3-K36 trimethylation', 'histone H3-K4 dimethylation', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'histone H3-K4 trimethylation', 'histone H3-K9 methylation', 'homologous chromosome pairing at meiosis', 'male gamete generation', 'meiotic gene conversion', 'negative regulation of apoptotic process', 'positive regulation of fertilization', 'positive regulation of histone H3-K36 trimethylation', 'positive regulation of histone H3-K4 trimethylation', 'positive regulation of reciprocal meiotic recombination', 'regulation of gene expression', 'regulation of transcription, DNA-templated']['chromatin organization', 'double-strand break repair involved in meiotic recombination', 'female gamete generation', 'histone H3-K36 dimethylation', 'histone H3-K36 trimethylation', 'histone H3-K4 dimethylation', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'histone H3-K4 trimethylation', 'histone H3-K9 methylation', 'homologous chromosome pairing at meiosis', 'male gamete generation', 'meiotic gene conversion', 'negative regulation of apoptotic process', 'positive regulation of fertilization', 'positive regulation of histone H3-K36 trimethylation', 'positive regulation of histone H3-K4 trimethylation', 'positive regulation of reciprocal meiotic recombination', 'regulation of gene expression', 'regulation of transcription, DNA-templated']
Synapsin-2
224
Synapsin-2
224
9.5
70
0.15
Q63537Q63537['calcium-ion regulated exocytosis', 'neurotransmitter secretion', 'regulation of neurotransmitter secretion', 'synaptic vesicle clustering', 'synaptic vesicle cycle']['calcium-ion regulated exocytosis', 'neurotransmitter secretion', 'regulation of neurotransmitter secretion', 'synaptic vesicle clustering', 'synaptic vesicle cycle']
Whirlin
866
Whirlin
866
9.5
64
0.16
Q80VW5Q80VW5['auditory receptor cell stereocilium organization', 'cerebellar Purkinje cell layer formation', 'detection of mechanical stimulus involved in sensory perception of sound', 'establishment of localization in cell', 'establishment of protein localization', 'inner ear receptor cell differentiation', 'inner ear receptor cell stereocilium organization', 'paranodal junction maintenance', 'positive regulation of gene expression', 'retina homeostasis', 'sensory perception of light stimulus', 'sensory perception of sound']['auditory receptor cell stereocilium organization', 'cerebellar Purkinje cell layer formation', 'detection of mechanical stimulus involved in sensory perception of sound', 'establishment of localization in cell', 'establishment of protein localization', 'inner ear receptor cell differentiation', 'inner ear receptor cell stereocilium organization', 'paranodal junction maintenance', 'positive regulation of gene expression', 'retina homeostasis', 'sensory perception of light stimulus', 'sensory perception of sound']
Platelet-derived growth factor subunit B
180
Platelet-derived growth factor subunit B
124
9.5
55
0.19
P01127P01127['activation of protein kinase activity', 'activation of protein kinase B activity', 'cell chemotaxis', 'cellular response to growth factor stimulus', 'cellular response to mycophenolic acid', 'cellular response to platelet-derived growth factor stimulus', 'embryonic placenta development', 'heart development', 'interleukin-18-mediated signaling pathway', 'metanephric glomerular mesangial cell development', 'monocyte chemotaxis', 'negative regulation of gene expression', 'negative regulation of miRNA transcription', 'negative regulation of phosphatidylinositol biosynthetic process', 'negative regulation of platelet activation', 'negative regulation of protein binding', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular associated smooth muscle cell differentiation', 'paracrine signaling', 'peptidyl-serine phosphorylation', 'peptidyl-tyrosine phosphorylation', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of calcium ion import', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell-substrate adhesion', 'positive regulation of chemotaxis', 'positive regulation of cyclin-dependent protein serine/threonine kinase activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glomerular filtration', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of hyaluronan biosynthetic process', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of metanephric mesenchymal cell migration', 'positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway', 'positive regulation of miRNA transcription', 'positive regulation of mitotic nuclear division', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular associated smooth muscle cell dedifferentiation', 'positive regulation of vascular associated smooth muscle cell migration', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase C signaling', 'protein phosphorylation', 'reactive oxygen species metabolic process', 'response to wounding']['activation of protein kinase activity', 'activation of protein kinase B activity', 'cell chemotaxis', 'cellular response to growth factor stimulus', 'cellular response to mycophenolic acid', 'cellular response to platelet-derived growth factor stimulus', 'embryonic placenta development', 'heart development', 'interleukin-18-mediated signaling pathway', 'metanephric glomerular mesangial cell development', 'monocyte chemotaxis', 'negative regulation of gene expression', 'negative regulation of miRNA transcription', 'negative regulation of phosphatidylinositol biosynthetic process', 'negative regulation of platelet activation', 'negative regulation of protein binding', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular associated smooth muscle cell differentiation', 'paracrine signaling', 'peptidyl-serine phosphorylation', 'peptidyl-tyrosine phosphorylation', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of calcium ion import', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell-substrate adhesion', 'positive regulation of chemotaxis', 'positive regulation of cyclin-dependent protein serine/threonine kinase activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glomerular filtration', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of hyaluronan biosynthetic process', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of metanephric mesenchymal cell migration', 'positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway', 'positive regulation of miRNA transcription', 'positive regulation of mitotic nuclear division', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular associated smooth muscle cell dedifferentiation', 'positive regulation of vascular associated smooth muscle cell migration', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase C signaling', 'protein phosphorylation', 'reactive oxygen species metabolic process', 'response to wounding']
Caspase-1
364
Caspase-1
397
9.5
70
0.15
P29466P29466['apoptotic process', 'cellular response to interferon-gamma', 'cellular response to lipopolysaccharide', 'cellular response to mechanical stimulus', 'cellular response to organic substance', 'cytokine precursor processing', 'defense response to virus', 'icosanoid biosynthetic process', 'osmosensory signaling pathway', 'pattern recognition receptor signaling pathway', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of tumor necrosis factor-mediated signaling pathway', 'protein autoprocessing', 'proteolysis', 'pyroptosis', 'regulation of apoptotic process', 'regulation of inflammatory response', 'signal transduction', 'signaling receptor ligand precursor processing']['apoptotic process', 'cellular response to interferon-gamma', 'cellular response to lipopolysaccharide', 'cellular response to mechanical stimulus', 'cellular response to organic substance', 'cytokine precursor processing', 'defense response to virus', 'icosanoid biosynthetic process', 'osmosensory signaling pathway', 'pattern recognition receptor signaling pathway', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of tumor necrosis factor-mediated signaling pathway', 'protein autoprocessing', 'proteolysis', 'pyroptosis', 'regulation of apoptotic process', 'regulation of inflammatory response', 'signal transduction', 'signaling receptor ligand precursor processing']
Neutrophil defensin 1
94
Neutrophil defensin 1
83
9.5
nan
nan
P59665P59665['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']
Prosaposin
106
Prosaposin
106
9.5
76
0.14
Q61207Q61207['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'antigen processing and presentation', 'cellular response to organic substance', 'ceramide metabolic process', 'cerebellar Purkinje cell differentiation', 'cochlea development', 'corneocyte development', 'cornified envelope assembly', 'developmental growth', 'epithelial cell differentiation involved in prostate gland development', 'galactosylceramide catabolic process', 'ganglioside GM1 transport to membrane', 'gene expression', 'glucosylceramide metabolic process', 'glycolipid metabolic process', 'inclusion body assembly', 'intracellular protein transport', 'lysosomal protein catabolic process', 'lysosomal transport', 'membrane lipid metabolic process', 'micturition', 'myelination', 'negative regulation of hydrogen peroxide-induced cell death', 'nervous system process', 'neuromuscular process controlling balance', 'NK T cell differentiation', 'positive regulation of beta-galactosidase activity', 'positive regulation of hydrolase activity', 'positive regulation of MAPK cascade', 'prostate gland growth', 'protein secretion', 'regulation of lipid metabolic process', 'regulation of MAPK cascade', 'sensory perception of sound', 'sphingolipid metabolic process', 'walking behavior']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'antigen processing and presentation', 'cellular response to organic substance', 'ceramide metabolic process', 'cerebellar Purkinje cell differentiation', 'cochlea development', 'corneocyte development', 'cornified envelope assembly', 'developmental growth', 'epithelial cell differentiation involved in prostate gland development', 'galactosylceramide catabolic process', 'ganglioside GM1 transport to membrane', 'gene expression', 'glucosylceramide metabolic process', 'glycolipid metabolic process', 'inclusion body assembly', 'intracellular protein transport', 'lysosomal protein catabolic process', 'lysosomal transport', 'membrane lipid metabolic process', 'micturition', 'myelination', 'negative regulation of hydrogen peroxide-induced cell death', 'nervous system process', 'neuromuscular process controlling balance', 'NK T cell differentiation', 'positive regulation of beta-galactosidase activity', 'positive regulation of hydrolase activity', 'positive regulation of MAPK cascade', 'prostate gland growth', 'protein secretion', 'regulation of lipid metabolic process', 'regulation of MAPK cascade', 'sensory perception of sound', 'sphingolipid metabolic process', 'walking behavior']
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
295
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
295
8.7
82
0.14
O43252O43252["3'-phosphoadenosine 5'-phosphosulfate biosynthetic process", 'phosphorylation', 'skeletal system development', 'sulfate assimilation']["3'-phosphoadenosine 5'-phosphosulfate biosynthetic process", 'phosphorylation', 'skeletal system development', 'sulfate assimilation']
C-type lectin domain family 2 member I
92
C-type lectin domain family 2 member I
92
8.7
65
0.18
Q9WVF9Q9WVF9['membrane raft assembly', 'negative regulation of osteoclast differentiation', 'positive regulation of immunological synapse formation', 'receptor clustering', 'regulation of actin filament polymerization', 'regulation of interleukin-2 production', 'regulation of T cell proliferation', 'T cell receptor signaling pathway']['membrane raft assembly', 'negative regulation of osteoclast differentiation', 'positive regulation of immunological synapse formation', 'receptor clustering', 'regulation of actin filament polymerization', 'regulation of interleukin-2 production', 'regulation of T cell proliferation', 'T cell receptor signaling pathway']
Dihydropyrimidine dehydrogenase [NADP(+)]
82
Dihydropyrimidine dehydrogenase [NADP(+)]
953
10.0
84
0.12
Q28943Q28943['beta-alanine biosynthetic process', 'thymidine catabolic process', 'thymine catabolic process', 'uracil catabolic process']['beta-alanine biosynthetic process', 'thymidine catabolic process', 'thymine catabolic process', 'uracil catabolic process']
4-trimethylaminobutyraldehyde dehydrogenase
74
4-trimethylaminobutyraldehyde dehydrogenase
74
8.2
84
0.14
P49189P49189['carnitine biosynthetic process', 'cellular aldehyde metabolic process', 'hormone metabolic process', 'neurotransmitter biosynthetic process', 'protein homotetramerization']['carnitine biosynthetic process', 'cellular aldehyde metabolic process', 'hormone metabolic process', 'neurotransmitter biosynthetic process', 'protein homotetramerization']
Prosaposin
357
Prosaposin
318
10.0
77
0.13
P07602P07602['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'epithelial cell differentiation involved in prostate gland development', 'ganglioside GM1 transport to membrane', 'lysosomal transport', 'positive regulation of beta-galactosidase activity', 'prostate gland growth', 'regulation of autophagy', 'regulation of lipid metabolic process', 'sphingolipid metabolic process']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'epithelial cell differentiation involved in prostate gland development', 'ganglioside GM1 transport to membrane', 'lysosomal transport', 'positive regulation of beta-galactosidase activity', 'prostate gland growth', 'regulation of autophagy', 'regulation of lipid metabolic process', 'sphingolipid metabolic process']
Tumor necrosis factor receptor superfamily member 9
133
Tumor necrosis factor receptor superfamily member 9
121
8.7
78
0.15
Q07011Q07011['apoptotic process', 'negative regulation of cell population proliferation', 'regulation of cell population proliferation', 'regulation of immature T cell proliferation in thymus']['apoptotic process', 'negative regulation of cell population proliferation', 'regulation of cell population proliferation', 'regulation of immature T cell proliferation in thymus']
C-C motif chemokine 14
59
C-C motif chemokine 14
59
8.2
52
0.23
Q16627Q16627['cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']['cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']
Complement C5
728
Complement C5
728
8.2
72
0.17
P06684P06684['complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']['complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']
Glutamate receptor 2
78
Glutamate receptor 2
78
8.2
76
0.16
P19491P19491['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']
Bone morphogenetic protein 2
329
Bone morphogenetic protein 2
360
8.7
79
0.15
P12643P12643['ameloblast differentiation', 'animal organ morphogenesis', 'aortic valve development', 'astrocyte differentiation', 'atrioventricular canal morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'BMP signaling pathway involved in heart development', 'BMP signaling pathway involved in heart induction', 'bone mineralization', 'bone mineralization involved in bone maturation', 'branching involved in ureteric bud morphogenesis', 'cardiac atrium formation', 'cardiac epithelial to mesenchymal transition', 'cardiac jelly development', 'cardiac muscle cell differentiation', 'cardiac muscle tissue morphogenesis', 'cardiocyte differentiation', 'cell fate commitment', 'cell-cell signaling', 'cellular response to BMP stimulus', 'cellular response to organic cyclic compound', 'chondrocyte differentiation', 'corticotropin hormone secreting cell differentiation', 'embryonic heart tube anterior/posterior pattern specification', 'endocardial cushion formation', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'heart development', 'in utero embryonic development', 'inflammatory response', 'inner ear development', 'mesenchymal cell differentiation', 'mesenchymal cell proliferation involved in ureteric bud development', 'mesenchyme development', 'negative regulation of aldosterone biosynthetic process', 'negative regulation of calcium-independent cell-cell adhesion', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cardiac muscle cell differentiation', 'negative regulation of cell cycle', 'negative regulation of cell population proliferation', 'negative regulation of cortisol biosynthetic process', 'negative regulation of gene expression', 'negative regulation of insulin-like growth factor receptor signaling pathway', 'negative regulation of MAP kinase activity', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of steroid biosynthetic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of Wnt signaling pathway involved in heart development', 'Notch signaling pathway', 'odontogenesis of dentin-containing tooth', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'pericardium development', 'positive regulation of apoptotic process', 'positive regulation of astrocyte differentiation', 'positive regulation of bone mineralization', 'positive regulation of cartilage development', 'positive regulation of cell migration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell differentiation', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix constituent secretion', 'positive regulation of fat cell differentiation', 'positive regulation of gene expression', 'positive regulation of MAPK cascade', 'positive regulation of miRNA transcription', 'positive regulation of neuron differentiation', 'positive regulation of odontogenesis', 'positive regulation of ossification', 'positive regulation of osteoblast differentiation', 'positive regulation of osteoblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peroxisome proliferator activated receptor signaling pathway', 'positive regulation of phosphatase activity', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus', 'positive regulation of transcription, DNA-templated', 'positive regulation of Wnt signaling pathway', 'positive regulation of Wnt signaling pathway by BMP signaling pathway', 'protein destabilization', 'protein phosphorylation', 'proteoglycan metabolic process', 'regulation of odontogenesis of dentin-containing tooth', 'regulation of transcription, DNA-templated', 'response to bacterium', 'response to hypoxia', 'skeletal system development', 'SMAD protein signal transduction', 'telencephalon development', 'telencephalon regionalization', 'thyroid-stimulating hormone-secreting cell differentiation', 'transcription by RNA polymerase II', 'Wnt signaling pathway']['ameloblast differentiation', 'animal organ morphogenesis', 'aortic valve development', 'astrocyte differentiation', 'atrioventricular canal morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'BMP signaling pathway involved in heart development', 'BMP signaling pathway involved in heart induction', 'bone mineralization', 'bone mineralization involved in bone maturation', 'branching involved in ureteric bud morphogenesis', 'cardiac atrium formation', 'cardiac epithelial to mesenchymal transition', 'cardiac jelly development', 'cardiac muscle cell differentiation', 'cardiac muscle tissue morphogenesis', 'cardiocyte differentiation', 'cell fate commitment', 'cell-cell signaling', 'cellular response to BMP stimulus', 'cellular response to organic cyclic compound', 'chondrocyte differentiation', 'corticotropin hormone secreting cell differentiation', 'embryonic heart tube anterior/posterior pattern specification', 'endocardial cushion formation', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'heart development', 'in utero embryonic development', 'inflammatory response', 'inner ear development', 'mesenchymal cell differentiation', 'mesenchymal cell proliferation involved in ureteric bud development', 'mesenchyme development', 'negative regulation of aldosterone biosynthetic process', 'negative regulation of calcium-independent cell-cell adhesion', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cardiac muscle cell differentiation', 'negative regulation of cell cycle', 'negative regulation of cell population proliferation', 'negative regulation of cortisol biosynthetic process', 'negative regulation of gene expression', 'negative regulation of insulin-like growth factor receptor signaling pathway', 'negative regulation of MAP kinase activity', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of steroid biosynthetic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of Wnt signaling pathway involved in heart development', 'Notch signaling pathway', 'odontogenesis of dentin-containing tooth', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'pericardium development', 'positive regulation of apoptotic process', 'positive regulation of astrocyte differentiation', 'positive regulation of bone mineralization', 'positive regulation of cartilage development', 'positive regulation of cell migration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell differentiation', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix constituent secretion', 'positive regulation of fat cell differentiation', 'positive regulation of gene expression', 'positive regulation of MAPK cascade', 'positive regulation of miRNA transcription', 'positive regulation of neuron differentiation', 'positive regulation of odontogenesis', 'positive regulation of ossification', 'positive regulation of osteoblast differentiation', 'positive regulation of osteoblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peroxisome proliferator activated receptor signaling pathway', 'positive regulation of phosphatase activity', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus', 'positive regulation of transcription, DNA-templated', 'positive regulation of Wnt signaling pathway', 'positive regulation of Wnt signaling pathway by BMP signaling pathway', 'protein destabilization', 'protein phosphorylation', 'proteoglycan metabolic process', 'regulation of odontogenesis of dentin-containing tooth', 'regulation of transcription, DNA-templated', 'response to bacterium', 'response to hypoxia', 'skeletal system development', 'SMAD protein signal transduction', 'telencephalon development', 'telencephalon regionalization', 'thyroid-stimulating hormone-secreting cell differentiation', 'transcription by RNA polymerase II', 'Wnt signaling pathway']
NKG2-D type II integral membrane protein
105
NKG2-D type II integral membrane protein
99
8.7
77
0.15
P26718P26718['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of interferon-gamma production', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of nitric oxide biosynthetic process', 'signal transduction', 'stimulatory C-type lectin receptor signaling pathway', 'T cell costimulation']['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of interferon-gamma production', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of nitric oxide biosynthetic process', 'signal transduction', 'stimulatory C-type lectin receptor signaling pathway', 'T cell costimulation']
Secreted frizzled-related protein 3
96
Secreted frizzled-related protein 3
96
10.0
73
0.14
P97401P97401['canonical Wnt signaling pathway', 'cochlea morphogenesis', 'convergent extension involved in organogenesis', 'epithelial cell development', 'hepatocyte differentiation', 'inner ear morphogenesis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cartilage development', 'negative regulation of cell development', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of hepatocyte differentiation', 'negative regulation of Wnt signaling pathway', 'neural crest cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of fat cell differentiation', 'somite development']['canonical Wnt signaling pathway', 'cochlea morphogenesis', 'convergent extension involved in organogenesis', 'epithelial cell development', 'hepatocyte differentiation', 'inner ear morphogenesis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cartilage development', 'negative regulation of cell development', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of hepatocyte differentiation', 'negative regulation of Wnt signaling pathway', 'neural crest cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of fat cell differentiation', 'somite development']
Defensin beta 4A
31
Defensin beta 4A
38
8.2
99
0.12
O15263O15263['antifungal innate immune response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell chemotaxis', 'chemotaxis', 'defense response to bacterium', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'G protein-coupled receptor signaling pathway', 'immune response', 'killing of cells of another organism', 'membrane disruption in another organism']['antifungal innate immune response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell chemotaxis', 'chemotaxis', 'defense response to bacterium', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'G protein-coupled receptor signaling pathway', 'immune response', 'killing of cells of another organism', 'membrane disruption in another organism']
Peroxisomal multifunctional enzyme type 2
230
Peroxisomal multifunctional enzyme type 2
277
8.7
59
0.2
P51659P51659['androgen metabolic process', 'estrogen metabolic process', 'fatty acid beta-oxidation', 'medium-chain fatty-acyl-CoA metabolic process', 'osteoblast differentiation', 'Sertoli cell development', 'very long-chain fatty acid metabolic process', 'very long-chain fatty-acyl-CoA metabolic process']['androgen metabolic process', 'estrogen metabolic process', 'fatty acid beta-oxidation', 'medium-chain fatty-acyl-CoA metabolic process', 'osteoblast differentiation', 'Sertoli cell development', 'very long-chain fatty acid metabolic process', 'very long-chain fatty-acyl-CoA metabolic process']
Elafin
83
Elafin
109
8.7
66
0.17
P19957P19957['antibacterial humoral response', 'copulation', 'innate immune response', 'peptide cross-linking']['antibacterial humoral response', 'copulation', 'innate immune response', 'peptide cross-linking']
Serine hydroxymethyltransferase, mitochondrial
68
Serine hydroxymethyltransferase, mitochondrial
91
8.2
83
0.15
P34897P34897['folic acid metabolic process', 'glycine biosynthetic process from serine', 'glycine metabolic process', 'L-serine biosynthetic process', 'L-serine catabolic process', 'L-serine metabolic process', 'one-carbon metabolic process', 'positive regulation of cell population proliferation', 'protein homotetramerization', 'protein K63-linked deubiquitination', 'protein tetramerization', 'purine nucleobase biosynthetic process', 'regulation of aerobic respiration', 'regulation of mitochondrial translation', 'regulation of oxidative phosphorylation', 'response to type I interferon', 'tetrahydrofolate interconversion', 'tetrahydrofolate metabolic process']['folic acid metabolic process', 'glycine biosynthetic process from serine', 'glycine metabolic process', 'L-serine biosynthetic process', 'L-serine catabolic process', 'L-serine metabolic process', 'one-carbon metabolic process', 'positive regulation of cell population proliferation', 'protein homotetramerization', 'protein K63-linked deubiquitination', 'protein tetramerization', 'purine nucleobase biosynthetic process', 'regulation of aerobic respiration', 'regulation of mitochondrial translation', 'regulation of oxidative phosphorylation', 'response to type I interferon', 'tetrahydrofolate interconversion', 'tetrahydrofolate metabolic process']
Bleomycin hydrolase
223
Bleomycin hydrolase
40
8.7
77
0.15
Q13867Q13867['homocysteine catabolic process', 'protein polyubiquitination', 'proteolysis', 'response to toxic substance', 'response to xenobiotic stimulus']['homocysteine catabolic process', 'protein polyubiquitination', 'proteolysis', 'response to toxic substance', 'response to xenobiotic stimulus']
Platelet factor 4
83
Platelet factor 4
43
8.7
76
0.15
P02776P02776['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'defense response to protozoan', 'inflammatory response', 'killing by host of symbiont cells', 'killing of cells of another organism', 'leukocyte chemotaxis', 'negative regulation of angiogenesis', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of megakaryocyte differentiation', 'negative regulation of MHC class II biosynthetic process', 'neutrophil chemotaxis', 'platelet activation', 'positive regulation of gene expression', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of macrophage differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'regulation of cell population proliferation']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'defense response to protozoan', 'inflammatory response', 'killing by host of symbiont cells', 'killing of cells of another organism', 'leukocyte chemotaxis', 'negative regulation of angiogenesis', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of megakaryocyte differentiation', 'negative regulation of MHC class II biosynthetic process', 'neutrophil chemotaxis', 'platelet activation', 'positive regulation of gene expression', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of macrophage differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'regulation of cell population proliferation']
Growth/differentiation factor 8
340
Growth/differentiation factor 8
314
8.2
72
0.17
O08689O08689['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
Beta-nerve growth factor
231
Beta-nerve growth factor
231
8.7
106
0.11
P01138P01138['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'extrinsic apoptotic signaling pathway via death domain receptors', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of cell population proliferation', 'negative regulation of neuron apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of collateral sprouting', 'positive regulation of DNA binding', 'positive regulation of gene expression', 'positive regulation of neuron differentiation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of Ras protein signal transduction', 'regulation of neuron differentiation', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'extrinsic apoptotic signaling pathway via death domain receptors', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of cell population proliferation', 'negative regulation of neuron apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of collateral sprouting', 'positive regulation of DNA binding', 'positive regulation of gene expression', 'positive regulation of neuron differentiation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of Ras protein signal transduction', 'regulation of neuron differentiation', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Insulin
31
Insulin
96
8.7
48
0.24
P01308P01308['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']
Albumin
582
Albumin
582
8.7
79
0.15
P02769P02769['cellular response to starvation', 'maintenance of mitochondrion location', 'negative regulation of apoptotic process']['cellular response to starvation', 'maintenance of mitochondrion location', 'negative regulation of apoptotic process']
Squalene monooxygenase
558
Squalene monooxygenase
558
8.2
68
0.18
Q14534Q14534['cellular aromatic compound metabolic process', 'cholesterol metabolic process', 'lipid droplet formation', 'regulation of cell population proliferation', 'response to organic substance', 'sterol biosynthetic process']['cellular aromatic compound metabolic process', 'cholesterol metabolic process', 'lipid droplet formation', 'regulation of cell population proliferation', 'response to organic substance', 'sterol biosynthetic process']
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
25
Guanine nucleotide-binding protein G(T) subunit gamma-T1
36
8.7
59
0.2
P62871P02698['adenylate cyclase-activating dopamine receptor signaling pathway', 'cellular response to catecholamine stimulus', 'cellular response to prostaglandin E stimulus', 'G protein-coupled receptor signaling pathway']['G protein-coupled receptor signaling pathway']
Putative nucleotidyltransferase MAB21L1
246
Putative nucleotidyltransferase MAB21L1
313
8.7
62
0.19
Q13394Q13394['anatomical structure morphogenesis', 'camera-type eye development', 'cell population proliferation', 'eye development', 'positive regulation of cell population proliferation']['anatomical structure morphogenesis', 'camera-type eye development', 'cell population proliferation', 'eye development', 'positive regulation of cell population proliferation']
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
305
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
93
8.2
82
0.15
Q0QF01Q007T0['mitochondrial electron transport, succinate to ubiquinone', 'nervous system development', 'respiratory electron transport chain', 'succinate metabolic process', 'tricarboxylic acid cycle']['tricarboxylic acid cycle']
Resistin
108
Resistin
108
8.6
77
0.15
Q99P87Q99P87['fat cell differentiation', 'negative regulation of feeding behavior', 'positive regulation of collagen metabolic process', 'positive regulation of progesterone secretion', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of synaptic transmission', 'response to insulin']['fat cell differentiation', 'negative regulation of feeding behavior', 'positive regulation of collagen metabolic process', 'positive regulation of progesterone secretion', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of synaptic transmission', 'response to insulin']
Potassium voltage-gated channel subfamily D member 3
93
Potassium voltage-gated channel subfamily D member 3
110
10.0
72
0.14
Q62897Q62897['cellular response to BMP stimulus', 'membrane repolarization', 'membrane repolarization during ventricular cardiac muscle cell action potential', 'potassium ion export across plasma membrane', 'potassium ion import across plasma membrane', 'potassium ion transmembrane transport', 'potassium ion transport', 'protein homooligomerization', 'regulation of heart rate by cardiac conduction', 'regulation of ion transmembrane transport', 'ventricular cardiac muscle cell membrane repolarization']['cellular response to BMP stimulus', 'membrane repolarization', 'membrane repolarization during ventricular cardiac muscle cell action potential', 'potassium ion export across plasma membrane', 'potassium ion import across plasma membrane', 'potassium ion transmembrane transport', 'potassium ion transport', 'protein homooligomerization', 'regulation of heart rate by cardiac conduction', 'regulation of ion transmembrane transport', 'ventricular cardiac muscle cell membrane repolarization']
Ephrin type-A receptor 4
108
Ephrin type-A receptor 4
108
8.2
80
0.15
P54764P54764['adherens junction organization', 'adult walking behavior', 'axon guidance', 'cell adhesion', 'cellular response to amyloid-beta', 'cochlea development', 'corticospinal tract morphogenesis', 'ephrin receptor signaling pathway', 'fasciculation of motor neuron axon', 'fasciculation of sensory neuron axon', 'glial cell migration', 'motor neuron axon guidance', 'negative regulation of axon regeneration', 'negative regulation of cell adhesion', 'negative regulation of cell migration', 'negative regulation of cellular response to hypoxia', 'negative regulation of epithelial to mesenchymal transition', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of long-term synaptic potentiation', 'negative regulation of neuron projection development', 'negative regulation of proteolysis involved in protein catabolic process', 'nephric duct morphogenesis', 'neuron projection fasciculation', 'neuron projection guidance', 'peptidyl-tyrosine phosphorylation', 'positive regulation of amyloid-beta formation', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of dendrite morphogenesis', 'positive regulation of JUN kinase activity', 'positive regulation of kinase activity', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of Rho guanyl-nucleotide exchange factor activity', 'protein autophosphorylation', 'protein stabilization', 'regulation of astrocyte differentiation', 'regulation of axonogenesis', 'regulation of dendritic spine morphogenesis', 'regulation of GTPase activity', 'regulation of modification of synaptic structure', 'synapse pruning', 'transmembrane receptor protein tyrosine kinase signaling pathway']['adherens junction organization', 'adult walking behavior', 'axon guidance', 'cell adhesion', 'cellular response to amyloid-beta', 'cochlea development', 'corticospinal tract morphogenesis', 'ephrin receptor signaling pathway', 'fasciculation of motor neuron axon', 'fasciculation of sensory neuron axon', 'glial cell migration', 'motor neuron axon guidance', 'negative regulation of axon regeneration', 'negative regulation of cell adhesion', 'negative regulation of cell migration', 'negative regulation of cellular response to hypoxia', 'negative regulation of epithelial to mesenchymal transition', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of long-term synaptic potentiation', 'negative regulation of neuron projection development', 'negative regulation of proteolysis involved in protein catabolic process', 'nephric duct morphogenesis', 'neuron projection fasciculation', 'neuron projection guidance', 'peptidyl-tyrosine phosphorylation', 'positive regulation of amyloid-beta formation', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of dendrite morphogenesis', 'positive regulation of JUN kinase activity', 'positive regulation of kinase activity', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of Rho guanyl-nucleotide exchange factor activity', 'protein autophosphorylation', 'protein stabilization', 'regulation of astrocyte differentiation', 'regulation of axonogenesis', 'regulation of dendritic spine morphogenesis', 'regulation of GTPase activity', 'regulation of modification of synaptic structure', 'synapse pruning', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Growth/differentiation factor 5
466
Growth/differentiation factor 5
465
8.7
81
0.14
P43026P43026['BMP signaling pathway', 'cell-cell signaling', 'chondroblast differentiation', 'chondrocyte differentiation', 'embryonic limb morphogenesis', 'forelimb morphogenesis', 'hindlimb morphogenesis', 'mesenchymal cell apoptotic process', 'negative regulation of chondrocyte differentiation', 'negative regulation of epithelial cell proliferation', 'negative regulation of mesenchymal cell apoptotic process', 'negative regulation of neuron apoptotic process', 'ossification involved in bone remodeling', 'positive regulation of BMP signaling pathway', 'positive regulation of chondrocyte differentiation', 'positive regulation of neuron differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'regulation of multicellular organism growth', 'regulation of SMAD protein signal transduction', 'response to mechanical stimulus', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['BMP signaling pathway', 'cell-cell signaling', 'chondroblast differentiation', 'chondrocyte differentiation', 'embryonic limb morphogenesis', 'forelimb morphogenesis', 'hindlimb morphogenesis', 'mesenchymal cell apoptotic process', 'negative regulation of chondrocyte differentiation', 'negative regulation of epithelial cell proliferation', 'negative regulation of mesenchymal cell apoptotic process', 'negative regulation of neuron apoptotic process', 'ossification involved in bone remodeling', 'positive regulation of BMP signaling pathway', 'positive regulation of chondrocyte differentiation', 'positive regulation of neuron differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'regulation of multicellular organism growth', 'regulation of SMAD protein signal transduction', 'response to mechanical stimulus', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
Aldo-keto reductase family 1 member C2
7
Aldo-keto reductase family 1 member C2
7
8.2
76
0.16
P52895P52895['cellular response to jasmonic acid stimulus', 'cellular response to prostaglandin D stimulus', 'daunorubicin metabolic process', 'digestion', 'doxorubicin metabolic process', 'epithelial cell differentiation', 'G protein-coupled receptor signaling pathway', 'positive regulation of cell population proliferation', 'positive regulation of protein kinase B signaling', 'progesterone metabolic process', 'prostaglandin metabolic process', 'steroid metabolic process']['cellular response to jasmonic acid stimulus', 'cellular response to prostaglandin D stimulus', 'daunorubicin metabolic process', 'digestion', 'doxorubicin metabolic process', 'epithelial cell differentiation', 'G protein-coupled receptor signaling pathway', 'positive regulation of cell population proliferation', 'positive regulation of protein kinase B signaling', 'progesterone metabolic process', 'prostaglandin metabolic process', 'steroid metabolic process']
Bone morphogenetic protein 10
356
Bone morphogenetic protein 10
388
8.7
80
0.14
O95393O95393['activin receptor signaling pathway', 'adult heart development', 'atrial cardiac muscle tissue morphogenesis', 'BMP signaling pathway', 'cardiac muscle cell proliferation', 'cell adhesion', 'heart trabecula formation', 'kidney development', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of endothelial cell migration', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cartilage development', 'positive regulation of cell proliferation involved in heart morphogenesis', 'positive regulation of gene expression', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of sarcomere organization', 'positive regulation of transcription, DNA-templated', 'regulation of cardiac muscle contraction', 'regulation of cardiac muscle hypertrophy in response to stress', 'sarcomere organization', 'SMAD protein signal transduction', 'ventricular cardiac muscle cell development', 'ventricular cardiac muscle tissue morphogenesis']['activin receptor signaling pathway', 'adult heart development', 'atrial cardiac muscle tissue morphogenesis', 'BMP signaling pathway', 'cardiac muscle cell proliferation', 'cell adhesion', 'heart trabecula formation', 'kidney development', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of endothelial cell migration', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cartilage development', 'positive regulation of cell proliferation involved in heart morphogenesis', 'positive regulation of gene expression', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of sarcomere organization', 'positive regulation of transcription, DNA-templated', 'regulation of cardiac muscle contraction', 'regulation of cardiac muscle hypertrophy in response to stress', 'sarcomere organization', 'SMAD protein signal transduction', 'ventricular cardiac muscle cell development', 'ventricular cardiac muscle tissue morphogenesis']
Integrin beta-2
36
Integrin beta-2
467
10.0
72
0.14
P05107P05107['amyloid-beta clearance', 'apoptotic process', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-cell adhesion', 'cell-cell adhesion via plasma-membrane adhesion molecules', 'cell-cell signaling', 'cell-matrix adhesion', 'cellular response to low-density lipoprotein particle stimulus', 'endodermal cell differentiation', 'heterotypic cell-cell adhesion', 'inflammatory response', 'integrin-mediated signaling pathway', 'leukocyte cell-cell adhesion', 'microglial cell activation', 'negative regulation of dopamine metabolic process', 'neutrophil chemotaxis', 'neutrophil migration', 'phagocytosis, engulfment', 'positive regulation of leukocyte adhesion to vascular endothelial cell', 'positive regulation of neuron death', 'positive regulation of neutrophil degranulation', 'positive regulation of prostaglandin-E synthase activity', 'positive regulation of protein targeting to membrane', 'positive regulation of superoxide anion generation', 'receptor clustering', 'receptor internalization', 'receptor-mediated endocytosis', 'regulation of cell shape', 'regulation of peptidyl-tyrosine phosphorylation']['amyloid-beta clearance', 'apoptotic process', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-cell adhesion', 'cell-cell adhesion via plasma-membrane adhesion molecules', 'cell-cell signaling', 'cell-matrix adhesion', 'cellular response to low-density lipoprotein particle stimulus', 'endodermal cell differentiation', 'heterotypic cell-cell adhesion', 'inflammatory response', 'integrin-mediated signaling pathway', 'leukocyte cell-cell adhesion', 'microglial cell activation', 'negative regulation of dopamine metabolic process', 'neutrophil chemotaxis', 'neutrophil migration', 'phagocytosis, engulfment', 'positive regulation of leukocyte adhesion to vascular endothelial cell', 'positive regulation of neuron death', 'positive regulation of neutrophil degranulation', 'positive regulation of prostaglandin-E synthase activity', 'positive regulation of protein targeting to membrane', 'positive regulation of superoxide anion generation', 'receptor clustering', 'receptor internalization', 'receptor-mediated endocytosis', 'regulation of cell shape', 'regulation of peptidyl-tyrosine phosphorylation']
Proprotein convertase subtilisin/kexin type 9
378
Low-density lipoprotein receptor
329
8.2
75
0.16
Q8NBP7P01130['apoptotic process', 'cellular response to insulin stimulus', 'cellular response to starvation', 'cholesterol homeostasis', 'cholesterol metabolic process', 'kidney development', 'lipoprotein metabolic process', 'liver development', 'low-density lipoprotein particle receptor catabolic process', 'lysosomal transport', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of low-density lipoprotein particle receptor binding', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of receptor internalization', 'negative regulation of receptor recycling', 'negative regulation of receptor-mediated endocytosis involved in cholesterol transport', 'negative regulation of sodium ion transmembrane transporter activity', 'neurogenesis', 'neuron differentiation', 'phospholipid metabolic process', 'positive regulation of low-density lipoprotein particle receptor catabolic process', 'positive regulation of neuron apoptotic process', 'positive regulation of receptor internalization', 'protein autoprocessing', 'regulation of neuron apoptotic process', 'regulation of signaling receptor activity', 'triglyceride metabolic process']['amyloid-beta clearance', 'amyloid-beta clearance by cellular catabolic process', 'artery morphogenesis', 'cellular response to fatty acid', 'cellular response to low-density lipoprotein particle stimulus', 'cholesterol homeostasis', 'cholesterol import', 'cholesterol metabolic process', 'cholesterol transport', 'endocytosis', 'high-density lipoprotein particle clearance', 'intestinal cholesterol absorption', 'lipid metabolic process', 'lipoprotein catabolic process', 'long-term memory', 'low-density lipoprotein particle clearance', 'negative regulation of amyloid fibril formation', 'negative regulation of astrocyte activation', 'negative regulation of gene expression', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of microglial cell activation', 'negative regulation of protein metabolic process', 'negative regulation of receptor recycling', 'phagocytosis', 'phospholipid transport', 'plasma lipoprotein particle clearance', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of lysosomal protein catabolic process', 'positive regulation of triglyceride biosynthetic process', 'receptor-mediated endocytosis', 'receptor-mediated endocytosis involved in cholesterol transport', 'regulation of cholesterol metabolic process', 'regulation of phosphatidylcholine catabolic process', 'regulation of protein metabolic process', 'response to caloric restriction']
Vascular endothelial growth factor B
89
Vascular endothelial growth factor B
72
8.2
69
0.18
P49765P49765['cardiac muscle contraction', 'coronary vasculature development', 'induction of positive chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of gene expression', 'negative regulation of neuron apoptotic process', 'positive regulation of angiogenesis', 'positive regulation of cell division', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'positive regulation of vascular wound healing', 'protein O-linked glycosylation', 'response to hypoxia', 'sprouting angiogenesis', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor signaling pathway']['cardiac muscle contraction', 'coronary vasculature development', 'induction of positive chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of gene expression', 'negative regulation of neuron apoptotic process', 'positive regulation of angiogenesis', 'positive regulation of cell division', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'positive regulation of vascular wound healing', 'protein O-linked glycosylation', 'response to hypoxia', 'sprouting angiogenesis', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor signaling pathway']
Cystatin-8
95
Cystatin-8
139
8.2
72
0.17
P32766P32766[][]
Serine protease 1
64
Pancreatic trypsin inhibitor
49
8.7
97
0.12
P00760P00974['digestion', 'proteolysis']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Interleukin-17A
99
Interleukin-17A
146
8.7
90
0.13
Q16552Q16552['adaptive immune response', 'apoptotic process', 'cell death', 'cell-cell signaling', 'cellular response to interleukin-1', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'fibroblast activation', 'granulocyte migration', 'immune response', 'inflammatory response', 'innate immune response', 'interleukin-17-mediated signaling pathway', 'intestinal epithelial structure maintenance', 'Notch signaling pathway', 'positive regulation of antimicrobial peptide production', 'positive regulation of bicellular tight junction assembly', 'positive regulation of chemokine (C-X-C motif) ligand 1 production', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-16 production', 'positive regulation of interleukin-23 production', 'positive regulation of interleukin-6 production', 'positive regulation of osteoclast differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production']['adaptive immune response', 'apoptotic process', 'cell death', 'cell-cell signaling', 'cellular response to interleukin-1', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'fibroblast activation', 'granulocyte migration', 'immune response', 'inflammatory response', 'innate immune response', 'interleukin-17-mediated signaling pathway', 'intestinal epithelial structure maintenance', 'Notch signaling pathway', 'positive regulation of antimicrobial peptide production', 'positive regulation of bicellular tight junction assembly', 'positive regulation of chemokine (C-X-C motif) ligand 1 production', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-16 production', 'positive regulation of interleukin-23 production', 'positive regulation of interleukin-6 production', 'positive regulation of osteoclast differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production']
Platelet-derived growth factor subunit B
134
Platelet-derived growth factor subunit B
124
8.2
60
0.2
P01127P01127['activation of protein kinase activity', 'activation of protein kinase B activity', 'cell chemotaxis', 'cellular response to growth factor stimulus', 'cellular response to mycophenolic acid', 'cellular response to platelet-derived growth factor stimulus', 'embryonic placenta development', 'heart development', 'interleukin-18-mediated signaling pathway', 'metanephric glomerular mesangial cell development', 'monocyte chemotaxis', 'negative regulation of gene expression', 'negative regulation of miRNA transcription', 'negative regulation of phosphatidylinositol biosynthetic process', 'negative regulation of platelet activation', 'negative regulation of protein binding', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular associated smooth muscle cell differentiation', 'paracrine signaling', 'peptidyl-serine phosphorylation', 'peptidyl-tyrosine phosphorylation', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of calcium ion import', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell-substrate adhesion', 'positive regulation of chemotaxis', 'positive regulation of cyclin-dependent protein serine/threonine kinase activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glomerular filtration', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of hyaluronan biosynthetic process', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of metanephric mesenchymal cell migration', 'positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway', 'positive regulation of miRNA transcription', 'positive regulation of mitotic nuclear division', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular associated smooth muscle cell dedifferentiation', 'positive regulation of vascular associated smooth muscle cell migration', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase C signaling', 'protein phosphorylation', 'reactive oxygen species metabolic process', 'response to wounding']['activation of protein kinase activity', 'activation of protein kinase B activity', 'cell chemotaxis', 'cellular response to growth factor stimulus', 'cellular response to mycophenolic acid', 'cellular response to platelet-derived growth factor stimulus', 'embryonic placenta development', 'heart development', 'interleukin-18-mediated signaling pathway', 'metanephric glomerular mesangial cell development', 'monocyte chemotaxis', 'negative regulation of gene expression', 'negative regulation of miRNA transcription', 'negative regulation of phosphatidylinositol biosynthetic process', 'negative regulation of platelet activation', 'negative regulation of protein binding', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular associated smooth muscle cell differentiation', 'paracrine signaling', 'peptidyl-serine phosphorylation', 'peptidyl-tyrosine phosphorylation', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of calcium ion import', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell-substrate adhesion', 'positive regulation of chemotaxis', 'positive regulation of cyclin-dependent protein serine/threonine kinase activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glomerular filtration', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of hyaluronan biosynthetic process', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of metanephric mesenchymal cell migration', 'positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway', 'positive regulation of miRNA transcription', 'positive regulation of mitotic nuclear division', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular associated smooth muscle cell dedifferentiation', 'positive regulation of vascular associated smooth muscle cell migration', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase C signaling', 'protein phosphorylation', 'reactive oxygen species metabolic process', 'response to wounding']
Chymotrypsinogen A
58
Amyloid-beta precursor protein
324
10.0
85
0.12
P00766P05067['digestion', 'proteolysis']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Acyloxyacyl hydrolase
41
Acyloxyacyl hydrolase
453
8.3
69
0.18
P28039P28039['fatty acid metabolic process', 'lipopolysaccharide catabolic process', 'negative regulation of inflammatory response']['fatty acid metabolic process', 'lipopolysaccharide catabolic process', 'negative regulation of inflammatory response']
Regulator of G-protein signaling 3
314
Regulator of G-protein signaling 3
354
8.6
64
0.18
P49796P49796['G protein-coupled receptor signaling pathway', 'negative regulation of signal transduction', 'regulation of G protein-coupled receptor signaling pathway', 'signal transduction']['G protein-coupled receptor signaling pathway', 'negative regulation of signal transduction', 'regulation of G protein-coupled receptor signaling pathway', 'signal transduction']
Glutathione S-transferase Mu 1
78
Glutathione S-transferase Mu 1
78
8.6
80
0.15
P09488P09488['cellular detoxification of nitrogen compound', 'glutathione derivative biosynthetic process', 'glutathione metabolic process', 'hepoxilin biosynthetic process', 'nitrobenzene metabolic process', 'prostaglandin metabolic process', 'xenobiotic catabolic process']['cellular detoxification of nitrogen compound', 'glutathione derivative biosynthetic process', 'glutathione metabolic process', 'hepoxilin biosynthetic process', 'nitrobenzene metabolic process', 'prostaglandin metabolic process', 'xenobiotic catabolic process']
Bone morphogenetic protein 2
360
Bone morphogenetic protein 2
361
8.6
82
0.14
P12643P12643['ameloblast differentiation', 'animal organ morphogenesis', 'aortic valve development', 'astrocyte differentiation', 'atrioventricular canal morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'BMP signaling pathway involved in heart development', 'BMP signaling pathway involved in heart induction', 'bone mineralization', 'bone mineralization involved in bone maturation', 'branching involved in ureteric bud morphogenesis', 'cardiac atrium formation', 'cardiac epithelial to mesenchymal transition', 'cardiac jelly development', 'cardiac muscle cell differentiation', 'cardiac muscle tissue morphogenesis', 'cardiocyte differentiation', 'cell fate commitment', 'cell-cell signaling', 'cellular response to BMP stimulus', 'cellular response to organic cyclic compound', 'chondrocyte differentiation', 'corticotropin hormone secreting cell differentiation', 'embryonic heart tube anterior/posterior pattern specification', 'endocardial cushion formation', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'heart development', 'in utero embryonic development', 'inflammatory response', 'inner ear development', 'mesenchymal cell differentiation', 'mesenchymal cell proliferation involved in ureteric bud development', 'mesenchyme development', 'negative regulation of aldosterone biosynthetic process', 'negative regulation of calcium-independent cell-cell adhesion', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cardiac muscle cell differentiation', 'negative regulation of cell cycle', 'negative regulation of cell population proliferation', 'negative regulation of cortisol biosynthetic process', 'negative regulation of gene expression', 'negative regulation of insulin-like growth factor receptor signaling pathway', 'negative regulation of MAP kinase activity', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of steroid biosynthetic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of Wnt signaling pathway involved in heart development', 'Notch signaling pathway', 'odontogenesis of dentin-containing tooth', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'pericardium development', 'positive regulation of apoptotic process', 'positive regulation of astrocyte differentiation', 'positive regulation of bone mineralization', 'positive regulation of cartilage development', 'positive regulation of cell migration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell differentiation', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix constituent secretion', 'positive regulation of fat cell differentiation', 'positive regulation of gene expression', 'positive regulation of MAPK cascade', 'positive regulation of miRNA transcription', 'positive regulation of neuron differentiation', 'positive regulation of odontogenesis', 'positive regulation of ossification', 'positive regulation of osteoblast differentiation', 'positive regulation of osteoblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peroxisome proliferator activated receptor signaling pathway', 'positive regulation of phosphatase activity', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus', 'positive regulation of transcription, DNA-templated', 'positive regulation of Wnt signaling pathway', 'positive regulation of Wnt signaling pathway by BMP signaling pathway', 'protein destabilization', 'protein phosphorylation', 'proteoglycan metabolic process', 'regulation of odontogenesis of dentin-containing tooth', 'regulation of transcription, DNA-templated', 'response to bacterium', 'response to hypoxia', 'skeletal system development', 'SMAD protein signal transduction', 'telencephalon development', 'telencephalon regionalization', 'thyroid-stimulating hormone-secreting cell differentiation', 'transcription by RNA polymerase II', 'Wnt signaling pathway']['ameloblast differentiation', 'animal organ morphogenesis', 'aortic valve development', 'astrocyte differentiation', 'atrioventricular canal morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'BMP signaling pathway involved in heart development', 'BMP signaling pathway involved in heart induction', 'bone mineralization', 'bone mineralization involved in bone maturation', 'branching involved in ureteric bud morphogenesis', 'cardiac atrium formation', 'cardiac epithelial to mesenchymal transition', 'cardiac jelly development', 'cardiac muscle cell differentiation', 'cardiac muscle tissue morphogenesis', 'cardiocyte differentiation', 'cell fate commitment', 'cell-cell signaling', 'cellular response to BMP stimulus', 'cellular response to organic cyclic compound', 'chondrocyte differentiation', 'corticotropin hormone secreting cell differentiation', 'embryonic heart tube anterior/posterior pattern specification', 'endocardial cushion formation', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'heart development', 'in utero embryonic development', 'inflammatory response', 'inner ear development', 'mesenchymal cell differentiation', 'mesenchymal cell proliferation involved in ureteric bud development', 'mesenchyme development', 'negative regulation of aldosterone biosynthetic process', 'negative regulation of calcium-independent cell-cell adhesion', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cardiac muscle cell differentiation', 'negative regulation of cell cycle', 'negative regulation of cell population proliferation', 'negative regulation of cortisol biosynthetic process', 'negative regulation of gene expression', 'negative regulation of insulin-like growth factor receptor signaling pathway', 'negative regulation of MAP kinase activity', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of steroid biosynthetic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of Wnt signaling pathway involved in heart development', 'Notch signaling pathway', 'odontogenesis of dentin-containing tooth', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'pericardium development', 'positive regulation of apoptotic process', 'positive regulation of astrocyte differentiation', 'positive regulation of bone mineralization', 'positive regulation of cartilage development', 'positive regulation of cell migration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell differentiation', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix constituent secretion', 'positive regulation of fat cell differentiation', 'positive regulation of gene expression', 'positive regulation of MAPK cascade', 'positive regulation of miRNA transcription', 'positive regulation of neuron differentiation', 'positive regulation of odontogenesis', 'positive regulation of ossification', 'positive regulation of osteoblast differentiation', 'positive regulation of osteoblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peroxisome proliferator activated receptor signaling pathway', 'positive regulation of phosphatase activity', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus', 'positive regulation of transcription, DNA-templated', 'positive regulation of Wnt signaling pathway', 'positive regulation of Wnt signaling pathway by BMP signaling pathway', 'protein destabilization', 'protein phosphorylation', 'proteoglycan metabolic process', 'regulation of odontogenesis of dentin-containing tooth', 'regulation of transcription, DNA-templated', 'response to bacterium', 'response to hypoxia', 'skeletal system development', 'SMAD protein signal transduction', 'telencephalon development', 'telencephalon regionalization', 'thyroid-stimulating hormone-secreting cell differentiation', 'transcription by RNA polymerase II', 'Wnt signaling pathway']
Bone morphogenetic protein 10
389
Bone morphogenetic protein 10
388
8.6
83
0.14
O95393O95393['activin receptor signaling pathway', 'adult heart development', 'atrial cardiac muscle tissue morphogenesis', 'BMP signaling pathway', 'cardiac muscle cell proliferation', 'cell adhesion', 'heart trabecula formation', 'kidney development', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of endothelial cell migration', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cartilage development', 'positive regulation of cell proliferation involved in heart morphogenesis', 'positive regulation of gene expression', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of sarcomere organization', 'positive regulation of transcription, DNA-templated', 'regulation of cardiac muscle contraction', 'regulation of cardiac muscle hypertrophy in response to stress', 'sarcomere organization', 'SMAD protein signal transduction', 'ventricular cardiac muscle cell development', 'ventricular cardiac muscle tissue morphogenesis']['activin receptor signaling pathway', 'adult heart development', 'atrial cardiac muscle tissue morphogenesis', 'BMP signaling pathway', 'cardiac muscle cell proliferation', 'cell adhesion', 'heart trabecula formation', 'kidney development', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of endothelial cell migration', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cartilage development', 'positive regulation of cell proliferation involved in heart morphogenesis', 'positive regulation of gene expression', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of sarcomere organization', 'positive regulation of transcription, DNA-templated', 'regulation of cardiac muscle contraction', 'regulation of cardiac muscle hypertrophy in response to stress', 'sarcomere organization', 'SMAD protein signal transduction', 'ventricular cardiac muscle cell development', 'ventricular cardiac muscle tissue morphogenesis']
Glycoprotein hormones alpha chain
83
Follitropin subunit beta
50
8.6
82
0.14
Q96QJ4P01225[]['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Ribonuclease inhibitor
409
Non-secretory ribonuclease
89
8.6
71
0.16
P13489P10153['mRNA catabolic process', 'regulation of angiogenesis']['chemotaxis', 'defense response to virus', 'innate immune response in mucosa', 'RNA catabolic process', 'RNA phosphodiester bond hydrolysis']
Protein cereblon
397
Protein cereblon
397
8.6
63
0.18
Q8C7D2Q8C7D2['locomotory exploration behavior', 'negative regulation of ion transmembrane transport', 'negative regulation of large conductance calcium-activated potassium channel activity', 'negative regulation of protein-containing complex assembly', 'positive regulation of protein-containing complex assembly', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination']['locomotory exploration behavior', 'negative regulation of ion transmembrane transport', 'negative regulation of large conductance calcium-activated potassium channel activity', 'negative regulation of protein-containing complex assembly', 'positive regulation of protein-containing complex assembly', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination']
Cytochrome b
323
Cytochrome b-c1 complex subunit 8
45
9.9
52
0.19
P00157P13271['mitochondrial electron transport, ubiquinol to cytochrome c', 'respiratory electron transport chain']['mitochondrial electron transport, ubiquinol to cytochrome c']
Growth/differentiation factor 15
240
Growth/differentiation factor 15
273
8.6
87
0.13
Q99988Q99988['BMP signaling pathway', 'cell-cell signaling', 'glial cell-derived neurotrophic factor receptor signaling pathway', 'negative regulation of growth hormone receptor signaling pathway', 'negative regulation of multicellular organism growth', 'positive regulation of MAPK cascade', 'positive regulation of myoblast fusion', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein kinase B signaling', 'reduction of food intake in response to dietary excess', 'signal transduction', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['BMP signaling pathway', 'cell-cell signaling', 'glial cell-derived neurotrophic factor receptor signaling pathway', 'negative regulation of growth hormone receptor signaling pathway', 'negative regulation of multicellular organism growth', 'positive regulation of MAPK cascade', 'positive regulation of myoblast fusion', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein kinase B signaling', 'reduction of food intake in response to dietary excess', 'signal transduction', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
Glutamate receptor 2
330
Glutamate receptor 2
330
8.6
72
0.16
P19491P19491['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']
C-C motif chemokine 3
57
C-C motif chemokine 3
57
8.3
64
0.19
P10147P10147['astrocyte cell migration', 'calcium ion transport', 'calcium-mediated signaling', 'cell activation', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytoskeleton organization', 'eosinophil chemotaxis', 'eosinophil degranulation', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'granulocyte chemotaxis', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'negative regulation of osteoclast differentiation', 'neutrophil chemotaxis', 'osteoblast differentiation', 'positive regulation of calcium ion import', 'positive regulation of calcium ion transport', 'positive regulation of calcium-mediated signaling', 'positive regulation of cell migration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of GTPase activity', 'positive regulation of inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of microglial cell activation', 'positive regulation of microglial cell migration', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of protein kinase B signaling', 'positive regulation of tumor necrosis factor production', 'protein kinase B signaling', 'regulation of behavior', 'regulation of cell shape', 'regulation of sensory perception of pain', 'release of sequestered calcium ion into cytosol by sarcoplasmic reticulum', 'response to cholesterol', 'response to toxic substance', 'signaling', 'T cell chemotaxis']['astrocyte cell migration', 'calcium ion transport', 'calcium-mediated signaling', 'cell activation', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytoskeleton organization', 'eosinophil chemotaxis', 'eosinophil degranulation', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'granulocyte chemotaxis', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'negative regulation of osteoclast differentiation', 'neutrophil chemotaxis', 'osteoblast differentiation', 'positive regulation of calcium ion import', 'positive regulation of calcium ion transport', 'positive regulation of calcium-mediated signaling', 'positive regulation of cell migration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of GTPase activity', 'positive regulation of inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of microglial cell activation', 'positive regulation of microglial cell migration', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of protein kinase B signaling', 'positive regulation of tumor necrosis factor production', 'protein kinase B signaling', 'regulation of behavior', 'regulation of cell shape', 'regulation of sensory perception of pain', 'release of sequestered calcium ion into cytosol by sarcoplasmic reticulum', 'response to cholesterol', 'response to toxic substance', 'signaling', 'T cell chemotaxis']
Defensin alpha 5
93
Defensin alpha 5
82
8.3
64
0.19
Q01523Q01523['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']
Growth/differentiation factor 2
360
Growth/differentiation factor 2
392
8.6
77
0.15
Q9UK05Q9UK05['activin receptor signaling pathway', 'angiogenesis', 'blood vessel morphogenesis', 'BMP signaling pathway', 'branching involved in blood vessel morphogenesis', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'negative regulation of angiogenesis', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell growth', 'negative regulation of DNA biosynthetic process', 'negative regulation of DNA replication', 'negative regulation of endothelial cell migration', 'negative regulation of endothelial cell proliferation', 'ossification', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of angiogenesis', 'positive regulation of BMP signaling pathway', 'positive regulation of cartilage development', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of interleukin-8 production', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'SMAD protein signal transduction', 'transcription by RNA polymerase II', 'vasculogenesis']['activin receptor signaling pathway', 'angiogenesis', 'blood vessel morphogenesis', 'BMP signaling pathway', 'branching involved in blood vessel morphogenesis', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'negative regulation of angiogenesis', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell growth', 'negative regulation of DNA biosynthetic process', 'negative regulation of DNA replication', 'negative regulation of endothelial cell migration', 'negative regulation of endothelial cell proliferation', 'ossification', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of angiogenesis', 'positive regulation of BMP signaling pathway', 'positive regulation of cartilage development', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of interleukin-8 production', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'SMAD protein signal transduction', 'transcription by RNA polymerase II', 'vasculogenesis']
Norrin
128
Norrin
93
8.6
70
0.17
Q00604Q00604['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']
Trypsin-3
121
Pancreatic trypsin inhibitor
49
8.3
95
0.13
P35030P00974['antimicrobial humoral response', 'digestion', 'endothelial cell migration', 'proteolysis', 'zymogen activation']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Adrenodoxin, mitochondrial
112
Adrenodoxin, mitochondrial
106
8.6
73
0.16
P10109P10109['cellular response to cAMP', 'cellular response to forskolin', 'cholesterol metabolic process', 'electron transport chain', 'hormone biosynthetic process', 'P450-containing electron transport chain', 'positive regulation of oxidoreductase activity', 'steroid biosynthetic process']['cellular response to cAMP', 'cellular response to forskolin', 'cholesterol metabolic process', 'electron transport chain', 'hormone biosynthetic process', 'P450-containing electron transport chain', 'positive regulation of oxidoreductase activity', 'steroid biosynthetic process']
Glucocorticoid receptor
492
Glucocorticoid receptor
482
8.3
70
0.17
P06536P06536['adrenal gland development', 'aging', 'androgen metabolic process', 'brain development', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to magnesium ion', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin remodeling', 'circadian rhythm', 'epigenetic maintenance of chromatin in transcription-competent conformation', 'female pregnancy', 'glucocorticoid metabolic process', 'glucocorticoid receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lung development', 'mammary gland duct morphogenesis', 'maternal behavior', 'muscle atrophy', 'negative regulation of apoptotic process', 'negative regulation of synaptic plasticity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular permeability', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of dendritic spine development', 'positive regulation of glucocorticoid receptor signaling pathway', 'positive regulation of glutamate secretion', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'protein-containing complex assembly', 'regulation of cell population proliferation', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of glucose metabolic process', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to activity', 'response to arsenic-containing substance', 'response to calcium ion', 'response to corticosterone', 'response to dexamethasone', 'response to electrical stimulus', 'response to inactivity', 'response to insulin', 'response to mercury ion', 'response to radiation']['adrenal gland development', 'aging', 'androgen metabolic process', 'brain development', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to magnesium ion', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin remodeling', 'circadian rhythm', 'epigenetic maintenance of chromatin in transcription-competent conformation', 'female pregnancy', 'glucocorticoid metabolic process', 'glucocorticoid receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lung development', 'mammary gland duct morphogenesis', 'maternal behavior', 'muscle atrophy', 'negative regulation of apoptotic process', 'negative regulation of synaptic plasticity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular permeability', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of dendritic spine development', 'positive regulation of glucocorticoid receptor signaling pathway', 'positive regulation of glutamate secretion', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'protein-containing complex assembly', 'regulation of cell population proliferation', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of glucose metabolic process', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to activity', 'response to arsenic-containing substance', 'response to calcium ion', 'response to corticosterone', 'response to dexamethasone', 'response to electrical stimulus', 'response to inactivity', 'response to insulin', 'response to mercury ion', 'response to radiation']
Urokinase-type plasminogen activator
315
Urokinase-type plasminogen activator
219
8.6
90
0.13
P06869P06869['angiogenesis', 'fibrinolysis', 'negative regulation of fibrinolysis', 'negative regulation of plasminogen activation', 'neuron death', 'plasminogen activation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of ovulation', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of smooth muscle cell migration', 'proteolysis', 'regulation of cell adhesion', 'regulation of cell adhesion mediated by integrin', 'regulation of cell population proliferation', 'regulation of fibrinolysis', 'regulation of hepatocyte proliferation', 'regulation of plasminogen activation', 'regulation of signaling receptor activity', 'regulation of smooth muscle cell migration', 'regulation of smooth muscle cell-matrix adhesion', 'response to hypoxia', 'skeletal muscle tissue regeneration', 'smooth muscle cell migration', 'urokinase plasminogen activator signaling pathway', 'wound healing']['angiogenesis', 'fibrinolysis', 'negative regulation of fibrinolysis', 'negative regulation of plasminogen activation', 'neuron death', 'plasminogen activation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of ovulation', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of smooth muscle cell migration', 'proteolysis', 'regulation of cell adhesion', 'regulation of cell adhesion mediated by integrin', 'regulation of cell population proliferation', 'regulation of fibrinolysis', 'regulation of hepatocyte proliferation', 'regulation of plasminogen activation', 'regulation of signaling receptor activity', 'regulation of smooth muscle cell migration', 'regulation of smooth muscle cell-matrix adhesion', 'response to hypoxia', 'skeletal muscle tissue regeneration', 'smooth muscle cell migration', 'urokinase plasminogen activator signaling pathway', 'wound healing']
T-cell surface glycoprotein YE1/48
145
T-cell surface glycoprotein YE1/48
145
8.6
53
0.22
P20937P20937['cell adhesion']['cell adhesion']
Glutathione S-transferase P
102
Glutathione S-transferase P
102
8.6
37
0.31
P09211P09211['cellular response to lipopolysaccharide', 'central nervous system development', 'common myeloid progenitor cell proliferation', 'glutathione derivative biosynthetic process', 'glutathione metabolic process', 'hepoxilin biosynthetic process', 'linoleic acid metabolic process', 'negative regulation of acute inflammatory response', 'negative regulation of apoptotic process', 'negative regulation of biosynthetic process', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of fibroblast proliferation', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of interleukin-1 beta production', 'negative regulation of JUN kinase activity', 'negative regulation of leukocyte proliferation', 'negative regulation of MAP kinase activity', 'negative regulation of MAPK cascade', 'negative regulation of monocyte chemotactic protein-1 production', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein kinase activity', 'negative regulation of stress-activated MAPK cascade', 'negative regulation of tumor necrosis factor production', 'negative regulation of tumor necrosis factor-mediated signaling pathway', 'nitric oxide storage', 'positive regulation of superoxide anion generation', 'prostaglandin metabolic process', 'regulation of ERK1 and ERK2 cascade', 'regulation of stress-activated MAPK cascade', 'response to reactive oxygen species', 'xenobiotic metabolic process']['cellular response to lipopolysaccharide', 'central nervous system development', 'common myeloid progenitor cell proliferation', 'glutathione derivative biosynthetic process', 'glutathione metabolic process', 'hepoxilin biosynthetic process', 'linoleic acid metabolic process', 'negative regulation of acute inflammatory response', 'negative regulation of apoptotic process', 'negative regulation of biosynthetic process', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of fibroblast proliferation', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of interleukin-1 beta production', 'negative regulation of JUN kinase activity', 'negative regulation of leukocyte proliferation', 'negative regulation of MAP kinase activity', 'negative regulation of MAPK cascade', 'negative regulation of monocyte chemotactic protein-1 production', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein kinase activity', 'negative regulation of stress-activated MAPK cascade', 'negative regulation of tumor necrosis factor production', 'negative regulation of tumor necrosis factor-mediated signaling pathway', 'nitric oxide storage', 'positive regulation of superoxide anion generation', 'prostaglandin metabolic process', 'regulation of ERK1 and ERK2 cascade', 'regulation of stress-activated MAPK cascade', 'response to reactive oxygen species', 'xenobiotic metabolic process']
Caspase-3
264
Caspase-3
264
8.3
93
0.13
P42574P42574['anterior neural tube closure', 'apoptotic process', 'apoptotic signaling pathway', 'axonal fasciculation', 'B cell homeostasis', 'cell fate commitment', 'cellular response to DNA damage stimulus', 'cellular response to staurosporine', 'epithelial cell apoptotic process', 'erythrocyte differentiation', 'execution phase of apoptosis', 'fibroblast apoptotic process', 'glial cell apoptotic process', 'heart development', 'hippocampus development', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway in response to osmotic stress', 'keratinocyte differentiation', 'learning or memory', 'leukocyte apoptotic process', 'luteolysis', 'negative regulation of activated T cell proliferation', 'negative regulation of apoptotic process', 'negative regulation of B cell proliferation', 'neuron apoptotic process', 'neuron differentiation', 'neurotrophin TRK receptor signaling pathway', 'platelet formation', 'positive regulation of amyloid-beta formation', 'positive regulation of apoptotic DNA fragmentation', 'positive regulation of apoptotic process', 'positive regulation of neuron apoptotic process', 'protein catabolic process', 'protein processing', 'proteolysis', 'regulation of macroautophagy', 'regulation of protein stability', 'response to amino acid', 'response to antibiotic', 'response to cobalt ion', 'response to estradiol', 'response to glucocorticoid', 'response to glucose', 'response to hydrogen peroxide', 'response to hypoxia', 'response to lipopolysaccharide', 'response to nicotine', 'response to tumor necrosis factor', 'response to UV', 'response to X-ray', 'response to xenobiotic stimulus', 'sensory perception of sound', 'striated muscle cell differentiation', 'T cell homeostasis', 'wound healing']['anterior neural tube closure', 'apoptotic process', 'apoptotic signaling pathway', 'axonal fasciculation', 'B cell homeostasis', 'cell fate commitment', 'cellular response to DNA damage stimulus', 'cellular response to staurosporine', 'epithelial cell apoptotic process', 'erythrocyte differentiation', 'execution phase of apoptosis', 'fibroblast apoptotic process', 'glial cell apoptotic process', 'heart development', 'hippocampus development', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway in response to osmotic stress', 'keratinocyte differentiation', 'learning or memory', 'leukocyte apoptotic process', 'luteolysis', 'negative regulation of activated T cell proliferation', 'negative regulation of apoptotic process', 'negative regulation of B cell proliferation', 'neuron apoptotic process', 'neuron differentiation', 'neurotrophin TRK receptor signaling pathway', 'platelet formation', 'positive regulation of amyloid-beta formation', 'positive regulation of apoptotic DNA fragmentation', 'positive regulation of apoptotic process', 'positive regulation of neuron apoptotic process', 'protein catabolic process', 'protein processing', 'proteolysis', 'regulation of macroautophagy', 'regulation of protein stability', 'response to amino acid', 'response to antibiotic', 'response to cobalt ion', 'response to estradiol', 'response to glucocorticoid', 'response to glucose', 'response to hydrogen peroxide', 'response to hypoxia', 'response to lipopolysaccharide', 'response to nicotine', 'response to tumor necrosis factor', 'response to UV', 'response to X-ray', 'response to xenobiotic stimulus', 'sensory perception of sound', 'striated muscle cell differentiation', 'T cell homeostasis', 'wound healing']
Poly [ADP-ribose] polymerase
970
Poly [ADP-ribose] polymerase
973
8.3
63
0.19
Q59FX0Q59FX0['positive regulation of telomere maintenance via telomerase', 'spindle assembly', 'Wnt signaling pathway']['positive regulation of telomere maintenance via telomerase', 'spindle assembly', 'Wnt signaling pathway']
Mitotic spindle assembly checkpoint protein MAD2B
70
DNA polymerase zeta catalytic subunit
1997
10.0
60
0.17
Q9D752O60673['actin filament organization', 'cell cycle', 'cell division', 'DNA damage response, signal transduction resulting in transcription', 'double-strand break repair', 'error-prone translesion synthesis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of double-strand break repair via homologous recombination', 'negative regulation of epithelial to mesenchymal transition', 'negative regulation of protein catabolic process', 'negative regulation of transcription by competitive promoter binding', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription regulatory region DNA binding', 'negative regulation of ubiquitin protein ligase activity', 'positive regulation of double-strand break repair via nonhomologous end joining', 'positive regulation of isotype switching', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of transcription, DNA-templated', 'regulation of cell growth', 'somatic diversification of immunoglobulins involved in immune response', 'telomere maintenance in response to DNA damage']['DNA-templated DNA replication', 'double-strand break repair via homologous recombination', 'error-prone translesion synthesis']
Acetyl-coenzyme A thioesterase
40
Acetyl-coenzyme A thioesterase
270
8.3
89
0.14
Q8WYK0Q8WYK0['acetyl-CoA metabolic process', 'acyl-CoA metabolic process', 'fatty acid metabolic process']['acetyl-CoA metabolic process', 'acyl-CoA metabolic process', 'fatty acid metabolic process']
Serine protease hepsin
150
Serine protease hepsin
277
9.9
81
0.12
P05981P05981['basement membrane disassembly', 'cochlea morphogenesis', 'detection of mechanical stimulus involved in sensory perception of sound', 'negative regulation of apoptotic process', 'negative regulation of epithelial cell proliferation', 'negative regulation of epithelial to mesenchymal transition', 'pilomotor reflex', 'positive regulation by host of viral transcription', 'positive regulation of cell growth', 'positive regulation of gene expression', 'positive regulation of hepatocyte proliferation', 'positive regulation of plasminogen activation', 'positive regulation of thyroid hormone generation', 'potassium ion transmembrane transport', 'proteolysis', 'regulation of cell shape', 'response to thyroid hormone']['basement membrane disassembly', 'cochlea morphogenesis', 'detection of mechanical stimulus involved in sensory perception of sound', 'negative regulation of apoptotic process', 'negative regulation of epithelial cell proliferation', 'negative regulation of epithelial to mesenchymal transition', 'pilomotor reflex', 'positive regulation by host of viral transcription', 'positive regulation of cell growth', 'positive regulation of gene expression', 'positive regulation of hepatocyte proliferation', 'positive regulation of plasminogen activation', 'positive regulation of thyroid hormone generation', 'potassium ion transmembrane transport', 'proteolysis', 'regulation of cell shape', 'response to thyroid hormone']
Biglycan
188
Biglycan
70
9.9
71
0.14
P21809P21809['articular cartilage development', 'bone development', 'peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan']['articular cartilage development', 'bone development', 'peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan']
Glutamate receptor ionotropic, delta-1
80
Glutamate receptor ionotropic, delta-1
80
8.6
81
0.14
Q61627Q61627['modulation of chemical synaptic transmission', 'social behavior', 'synaptic transmission, glutamatergic']['modulation of chemical synaptic transmission', 'social behavior', 'synaptic transmission, glutamatergic']
Cytidine deaminase
99
Cytidine deaminase
99
10.0
94
0.11
P56389P56389['cellular response to external biotic stimulus', 'CMP catabolic process', 'cytidine deamination', 'dCMP catabolic process', 'negative regulation of cell growth', 'negative regulation of nucleotide metabolic process', 'response to cycloheximide', 'UMP salvage']['cellular response to external biotic stimulus', 'CMP catabolic process', 'cytidine deamination', 'dCMP catabolic process', 'negative regulation of cell growth', 'negative regulation of nucleotide metabolic process', 'response to cycloheximide', 'UMP salvage']
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
305
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
113
8.3
81
0.15
Q0QF01Q007T0['mitochondrial electron transport, succinate to ubiquinone', 'nervous system development', 'respiratory electron transport chain', 'succinate metabolic process', 'tricarboxylic acid cycle']['tricarboxylic acid cycle']
Poly [ADP-ribose] polymerase tankyrase-1
1245
Poly [ADP-ribose] polymerase tankyrase-1
1245
8.6
59
0.2
O95271O95271['cell division', 'mitotic spindle organization', 'mRNA transport', 'negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric', 'negative regulation of telomere maintenance via telomere lengthening', 'negative regulation of telomeric DNA binding', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of telomerase activity', 'positive regulation of telomere capping', 'positive regulation of telomere maintenance via telomerase', 'positive regulation of transcription by RNA polymerase II', 'protein ADP-ribosylation', 'protein auto-ADP-ribosylation', 'protein localization to chromosome, telomeric region', 'protein poly-ADP-ribosylation', 'protein polyubiquitination', 'protein transport', 'regulation of telomere maintenance via telomerase', 'spindle assembly', 'Wnt signaling pathway']['cell division', 'mitotic spindle organization', 'mRNA transport', 'negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric', 'negative regulation of telomere maintenance via telomere lengthening', 'negative regulation of telomeric DNA binding', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of telomerase activity', 'positive regulation of telomere capping', 'positive regulation of telomere maintenance via telomerase', 'positive regulation of transcription by RNA polymerase II', 'protein ADP-ribosylation', 'protein auto-ADP-ribosylation', 'protein localization to chromosome, telomeric region', 'protein poly-ADP-ribosylation', 'protein polyubiquitination', 'protein transport', 'regulation of telomere maintenance via telomerase', 'spindle assembly', 'Wnt signaling pathway']
Kunitz-type protease inhibitor 1
77
Suppressor of tumorigenicity 14 protein
657
8.3
103
0.12
H3BR01Q9Y5Y6[]['epithelial cell morphogenesis involved in placental branching', 'keratinocyte differentiation', 'neural tube closure', 'protein catabolic process', 'proteolysis']
Caspase-4
109
Caspase-4
336
8.2
52
0.23
P49662P49662['apoptotic process', 'cellular response to amyloid-beta', 'defense response to Gram-positive bacterium', 'inflammatory response', 'innate immune response', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'positive regulation of inflammatory response', 'positive regulation of interleukin-18-mediated signaling pathway', 'positive regulation of tumor necrosis factor-mediated signaling pathway', 'protein autoprocessing', 'proteolysis', 'pyroptosis', 'regulation of apoptotic process', 'regulation of inflammatory response']['apoptotic process', 'cellular response to amyloid-beta', 'defense response to Gram-positive bacterium', 'inflammatory response', 'innate immune response', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'positive regulation of inflammatory response', 'positive regulation of interleukin-18-mediated signaling pathway', 'positive regulation of tumor necrosis factor-mediated signaling pathway', 'protein autoprocessing', 'proteolysis', 'pyroptosis', 'regulation of apoptotic process', 'regulation of inflammatory response']
Serine protease 1
64
Pancreatic trypsin inhibitor
73
9.9
86
0.12
P00760P00974['digestion', 'proteolysis']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
C-C motif chemokine 17
33
C-C motif chemokine 17
73
8.6
80
0.15
Q92583Q92583['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation of myoblast differentiation', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation of myoblast differentiation', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']
Ectodysplasin-A
332
Ectodysplasin-A
332
9.9
90
0.11
Q92838Q92838['animal organ development', 'canonical Wnt signaling pathway', 'cell differentiation', 'cell-matrix adhesion', 'cytokine-mediated signaling pathway', 'gene expression', 'hair follicle placode formation', 'immune response', 'odontogenesis of dentin-containing tooth', 'pigmentation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of gene expression', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'regulation of NIK/NF-kappaB signaling', 'salivary gland cavitation', 'trachea gland development']['animal organ development', 'canonical Wnt signaling pathway', 'cell differentiation', 'cell-matrix adhesion', 'cytokine-mediated signaling pathway', 'gene expression', 'hair follicle placode formation', 'immune response', 'odontogenesis of dentin-containing tooth', 'pigmentation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of gene expression', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'regulation of NIK/NF-kappaB signaling', 'salivary gland cavitation', 'trachea gland development']
Trypsin
49
Tissue factor pathway inhibitor
134
8.3
95
0.13
P00761P10646['digestion', 'proteolysis']['blood coagulation', 'cellular response to steroid hormone stimulus', 'negative regulation of blood coagulation']
Kunitz-type protease inhibitor 1
101
Suppressor of tumorigenicity 14 protein
657
8.6
91
0.13
H3BR01Q9Y5Y6[]['epithelial cell morphogenesis involved in placental branching', 'keratinocyte differentiation', 'neural tube closure', 'protein catabolic process', 'proteolysis']
PHD finger protein 6
283
PHD finger protein 6
215
9.9
78
0.13
Q8IWS0Q8IWS0['blastocyst hatching', 'negative regulation of transcription by RNA polymerase II', 'regulation of transcription by RNA polymerase II']['blastocyst hatching', 'negative regulation of transcription by RNA polymerase II', 'regulation of transcription by RNA polymerase II']
Nuclear receptor subfamily 1 group I member 3
233
Nuclear receptor subfamily 1 group I member 3
233
9.9
69
0.15
O35627O35627['cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'osteoblast differentiation', 'positive regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated']['cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'osteoblast differentiation', 'positive regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated']
Serine protease 1
64
Pancreatic trypsin inhibitor
49
8.3
96
0.13
P07477P00974['digestion', 'extracellular matrix disassembly', 'proteolysis']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Defensin beta 4A
31
Defensin beta 4A
53
9.9
90
0.11
O15263O15263['antifungal innate immune response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell chemotaxis', 'chemotaxis', 'defense response to bacterium', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'G protein-coupled receptor signaling pathway', 'immune response', 'killing of cells of another organism', 'membrane disruption in another organism']['antifungal innate immune response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell chemotaxis', 'chemotaxis', 'defense response to bacterium', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'G protein-coupled receptor signaling pathway', 'immune response', 'killing of cells of another organism', 'membrane disruption in another organism']
Bone morphogenetic protein 2
395
Bone morphogenetic protein 2
360
9.9
87
0.12
P12643P12643['ameloblast differentiation', 'animal organ morphogenesis', 'aortic valve development', 'astrocyte differentiation', 'atrioventricular canal morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'BMP signaling pathway involved in heart development', 'BMP signaling pathway involved in heart induction', 'bone mineralization', 'bone mineralization involved in bone maturation', 'branching involved in ureteric bud morphogenesis', 'cardiac atrium formation', 'cardiac epithelial to mesenchymal transition', 'cardiac jelly development', 'cardiac muscle cell differentiation', 'cardiac muscle tissue morphogenesis', 'cardiocyte differentiation', 'cell fate commitment', 'cell-cell signaling', 'cellular response to BMP stimulus', 'cellular response to organic cyclic compound', 'chondrocyte differentiation', 'corticotropin hormone secreting cell differentiation', 'embryonic heart tube anterior/posterior pattern specification', 'endocardial cushion formation', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'heart development', 'in utero embryonic development', 'inflammatory response', 'inner ear development', 'mesenchymal cell differentiation', 'mesenchymal cell proliferation involved in ureteric bud development', 'mesenchyme development', 'negative regulation of aldosterone biosynthetic process', 'negative regulation of calcium-independent cell-cell adhesion', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cardiac muscle cell differentiation', 'negative regulation of cell cycle', 'negative regulation of cell population proliferation', 'negative regulation of cortisol biosynthetic process', 'negative regulation of gene expression', 'negative regulation of insulin-like growth factor receptor signaling pathway', 'negative regulation of MAP kinase activity', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of steroid biosynthetic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of Wnt signaling pathway involved in heart development', 'Notch signaling pathway', 'odontogenesis of dentin-containing tooth', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'pericardium development', 'positive regulation of apoptotic process', 'positive regulation of astrocyte differentiation', 'positive regulation of bone mineralization', 'positive regulation of cartilage development', 'positive regulation of cell migration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell differentiation', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix constituent secretion', 'positive regulation of fat cell differentiation', 'positive regulation of gene expression', 'positive regulation of MAPK cascade', 'positive regulation of miRNA transcription', 'positive regulation of neuron differentiation', 'positive regulation of odontogenesis', 'positive regulation of ossification', 'positive regulation of osteoblast differentiation', 'positive regulation of osteoblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peroxisome proliferator activated receptor signaling pathway', 'positive regulation of phosphatase activity', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus', 'positive regulation of transcription, DNA-templated', 'positive regulation of Wnt signaling pathway', 'positive regulation of Wnt signaling pathway by BMP signaling pathway', 'protein destabilization', 'protein phosphorylation', 'proteoglycan metabolic process', 'regulation of odontogenesis of dentin-containing tooth', 'regulation of transcription, DNA-templated', 'response to bacterium', 'response to hypoxia', 'skeletal system development', 'SMAD protein signal transduction', 'telencephalon development', 'telencephalon regionalization', 'thyroid-stimulating hormone-secreting cell differentiation', 'transcription by RNA polymerase II', 'Wnt signaling pathway']['ameloblast differentiation', 'animal organ morphogenesis', 'aortic valve development', 'astrocyte differentiation', 'atrioventricular canal morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'BMP signaling pathway involved in heart development', 'BMP signaling pathway involved in heart induction', 'bone mineralization', 'bone mineralization involved in bone maturation', 'branching involved in ureteric bud morphogenesis', 'cardiac atrium formation', 'cardiac epithelial to mesenchymal transition', 'cardiac jelly development', 'cardiac muscle cell differentiation', 'cardiac muscle tissue morphogenesis', 'cardiocyte differentiation', 'cell fate commitment', 'cell-cell signaling', 'cellular response to BMP stimulus', 'cellular response to organic cyclic compound', 'chondrocyte differentiation', 'corticotropin hormone secreting cell differentiation', 'embryonic heart tube anterior/posterior pattern specification', 'endocardial cushion formation', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'heart development', 'in utero embryonic development', 'inflammatory response', 'inner ear development', 'mesenchymal cell differentiation', 'mesenchymal cell proliferation involved in ureteric bud development', 'mesenchyme development', 'negative regulation of aldosterone biosynthetic process', 'negative regulation of calcium-independent cell-cell adhesion', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cardiac muscle cell differentiation', 'negative regulation of cell cycle', 'negative regulation of cell population proliferation', 'negative regulation of cortisol biosynthetic process', 'negative regulation of gene expression', 'negative regulation of insulin-like growth factor receptor signaling pathway', 'negative regulation of MAP kinase activity', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of steroid biosynthetic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of Wnt signaling pathway involved in heart development', 'Notch signaling pathway', 'odontogenesis of dentin-containing tooth', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'pericardium development', 'positive regulation of apoptotic process', 'positive regulation of astrocyte differentiation', 'positive regulation of bone mineralization', 'positive regulation of cartilage development', 'positive regulation of cell migration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell differentiation', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix constituent secretion', 'positive regulation of fat cell differentiation', 'positive regulation of gene expression', 'positive regulation of MAPK cascade', 'positive regulation of miRNA transcription', 'positive regulation of neuron differentiation', 'positive regulation of odontogenesis', 'positive regulation of ossification', 'positive regulation of osteoblast differentiation', 'positive regulation of osteoblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peroxisome proliferator activated receptor signaling pathway', 'positive regulation of phosphatase activity', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus', 'positive regulation of transcription, DNA-templated', 'positive regulation of Wnt signaling pathway', 'positive regulation of Wnt signaling pathway by BMP signaling pathway', 'protein destabilization', 'protein phosphorylation', 'proteoglycan metabolic process', 'regulation of odontogenesis of dentin-containing tooth', 'regulation of transcription, DNA-templated', 'response to bacterium', 'response to hypoxia', 'skeletal system development', 'SMAD protein signal transduction', 'telencephalon development', 'telencephalon regionalization', 'thyroid-stimulating hormone-secreting cell differentiation', 'transcription by RNA polymerase II', 'Wnt signaling pathway']
Beta-nerve growth factor
231
Beta-nerve growth factor
231
8.3
96
0.13
P01139P01139['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'adult locomotory behavior', 'axon extension', 'circadian rhythm', 'extrinsic apoptotic signaling pathway in absence of ligand', 'extrinsic apoptotic signaling pathway via death domain receptors', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of type B pancreatic cell apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron projection development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of axon extension', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of collateral sprouting', 'positive regulation of DNA binding', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of neuron differentiation', 'positive regulation of neuron maturation', 'positive regulation of neuron projection development', 'positive regulation of neurotrophin TRK receptor signaling pathway', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein autophosphorylation', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of protein ubiquitination', 'positive regulation of Ras protein signal transduction', 'positive regulation of stem cell proliferation', 'protein phosphorylation', 'regulation of neuron differentiation', 'regulation of neurotransmitter secretion', 'regulation of release of sequestered calcium ion into cytosol', 'sensory perception of pain', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'adult locomotory behavior', 'axon extension', 'circadian rhythm', 'extrinsic apoptotic signaling pathway in absence of ligand', 'extrinsic apoptotic signaling pathway via death domain receptors', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of type B pancreatic cell apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron projection development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of axon extension', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of collateral sprouting', 'positive regulation of DNA binding', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of neuron differentiation', 'positive regulation of neuron maturation', 'positive regulation of neuron projection development', 'positive regulation of neurotrophin TRK receptor signaling pathway', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein autophosphorylation', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of protein ubiquitination', 'positive regulation of Ras protein signal transduction', 'positive regulation of stem cell proliferation', 'protein phosphorylation', 'regulation of neuron differentiation', 'regulation of neurotransmitter secretion', 'regulation of release of sequestered calcium ion into cytosol', 'sensory perception of pain', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Integrin alpha-X
655
Integrin alpha-X
655
8.5
72
0.16
P20702P20702['animal organ morphogenesis', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell-cell adhesion', 'cell-matrix adhesion', 'defense response to virus', 'heterotypic cell-cell adhesion', 'integrin-mediated signaling pathway', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of endothelial tube morphogenesis', 'positive regulation of gene expression', 'positive regulation of myelination']['animal organ morphogenesis', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell-cell adhesion', 'cell-matrix adhesion', 'defense response to virus', 'heterotypic cell-cell adhesion', 'integrin-mediated signaling pathway', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of endothelial tube morphogenesis', 'positive regulation of gene expression', 'positive regulation of myelination']
Ribonuclease inhibitor
30
Ribonuclease inhibitor
30
8.3
67
0.18
P13489P13489['mRNA catabolic process', 'regulation of angiogenesis']['mRNA catabolic process', 'regulation of angiogenesis']
MORC family CW-type zinc finger protein 3
413
MORC family CW-type zinc finger protein 3
416
8.5
72
0.16
Q14149Q14149['innate immune response', 'maintenance of protein location in nucleus', 'negative regulation of fibroblast proliferation', 'peptidyl-serine phosphorylation', 'positive regulation of cellular senescence', 'post-embryonic development', 'protein phosphorylation', 'protein stabilization']['innate immune response', 'maintenance of protein location in nucleus', 'negative regulation of fibroblast proliferation', 'peptidyl-serine phosphorylation', 'positive regulation of cellular senescence', 'post-embryonic development', 'protein phosphorylation', 'protein stabilization']
Platelet-derived growth factor subunit A
133
Platelet-derived growth factor subunit A
123
8.5
71
0.17
P04085P04085['actin cytoskeleton organization', 'angiogenesis', 'animal organ morphogenesis', 'cell activation', 'cell projection assembly', 'cell-cell signaling', 'cellular response to transforming growth factor beta stimulus', 'embryonic lung development', 'hair follicle development', 'inner ear development', 'lung alveolus development', 'male gonad development', 'negative chemotaxis', 'negative regulation of phosphatidylinositol biosynthetic process', 'negative regulation of platelet activation', 'platelet-derived growth factor receptor signaling pathway', 'platelet-derived growth factor receptor-alpha signaling pathway', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mesenchymal cell proliferation', 'positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'regulation of actin cytoskeleton organization', 'regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of smooth muscle cell migration', 'response to estradiol', 'response to hypoxia', 'response to inorganic substance', 'response to retinoic acid', 'response to wounding', 'response to xenobiotic stimulus', 'skin development', 'wound healing']['actin cytoskeleton organization', 'angiogenesis', 'animal organ morphogenesis', 'cell activation', 'cell projection assembly', 'cell-cell signaling', 'cellular response to transforming growth factor beta stimulus', 'embryonic lung development', 'hair follicle development', 'inner ear development', 'lung alveolus development', 'male gonad development', 'negative chemotaxis', 'negative regulation of phosphatidylinositol biosynthetic process', 'negative regulation of platelet activation', 'platelet-derived growth factor receptor signaling pathway', 'platelet-derived growth factor receptor-alpha signaling pathway', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mesenchymal cell proliferation', 'positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'regulation of actin cytoskeleton organization', 'regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of smooth muscle cell migration', 'response to estradiol', 'response to hypoxia', 'response to inorganic substance', 'response to retinoic acid', 'response to wounding', 'response to xenobiotic stimulus', 'skin development', 'wound healing']
Calcium/calmodulin-dependent protein kinase type II subunit delta
428
Calcium/calmodulin-dependent protein kinase type II subunit delta
428
8.5
103
0.11
Q13557Q13557['cardiac muscle cell contraction', 'cellular response to calcium ion', 'endoplasmic reticulum calcium ion homeostasis', 'negative regulation of sodium ion transmembrane transport', 'negative regulation of sodium ion transmembrane transporter activity', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of cardiac muscle hypertrophy', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of calcium ion transmembrane transport via high voltage-gated calcium channel', 'regulation of cardiac muscle cell action potential', 'regulation of cardiac muscle cell action potential involved in regulation of contraction', 'regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion', 'regulation of cell communication by electrical coupling', 'regulation of cell communication by electrical coupling involved in cardiac conduction', 'regulation of cell growth', 'regulation of cellular localization', 'regulation of heart contraction', 'regulation of heart rate by cardiac conduction', 'regulation of histone deacetylase activity', 'regulation of membrane depolarization', 'regulation of relaxation of cardiac muscle', 'regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of the force of heart contraction', 'regulation of transcription by RNA polymerase II', 'relaxation of cardiac muscle']['cardiac muscle cell contraction', 'cellular response to calcium ion', 'endoplasmic reticulum calcium ion homeostasis', 'negative regulation of sodium ion transmembrane transport', 'negative regulation of sodium ion transmembrane transporter activity', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of cardiac muscle hypertrophy', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of calcium ion transmembrane transport via high voltage-gated calcium channel', 'regulation of cardiac muscle cell action potential', 'regulation of cardiac muscle cell action potential involved in regulation of contraction', 'regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion', 'regulation of cell communication by electrical coupling', 'regulation of cell communication by electrical coupling involved in cardiac conduction', 'regulation of cell growth', 'regulation of cellular localization', 'regulation of heart contraction', 'regulation of heart rate by cardiac conduction', 'regulation of histone deacetylase activity', 'regulation of membrane depolarization', 'regulation of relaxation of cardiac muscle', 'regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of the force of heart contraction', 'regulation of transcription by RNA polymerase II', 'relaxation of cardiac muscle']
Protein cereblon
394
Protein cereblon
397
9.9
70
0.14
Q8C7D2Q8C7D2['locomotory exploration behavior', 'negative regulation of ion transmembrane transport', 'negative regulation of large conductance calcium-activated potassium channel activity', 'negative regulation of protein-containing complex assembly', 'positive regulation of protein-containing complex assembly', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination']['locomotory exploration behavior', 'negative regulation of ion transmembrane transport', 'negative regulation of large conductance calcium-activated potassium channel activity', 'negative regulation of protein-containing complex assembly', 'positive regulation of protein-containing complex assembly', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination']
Vascular endothelial growth factor B
82
Vascular endothelial growth factor B
72
8.5
69
0.17
P49765P49765['cardiac muscle contraction', 'coronary vasculature development', 'induction of positive chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of gene expression', 'negative regulation of neuron apoptotic process', 'positive regulation of angiogenesis', 'positive regulation of cell division', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'positive regulation of vascular wound healing', 'protein O-linked glycosylation', 'response to hypoxia', 'sprouting angiogenesis', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor signaling pathway']['cardiac muscle contraction', 'coronary vasculature development', 'induction of positive chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of gene expression', 'negative regulation of neuron apoptotic process', 'positive regulation of angiogenesis', 'positive regulation of cell division', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'positive regulation of vascular wound healing', 'protein O-linked glycosylation', 'response to hypoxia', 'sprouting angiogenesis', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor signaling pathway']
Prostasin
86
Pancreatic trypsin inhibitor
49
8.3
95
0.13
Q16651P00974['positive regulation of sodium ion transport', 'proteolysis']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Casein kinase II subunit beta
140
Casein kinase II subunit beta
140
9.9
63
0.16
P67870P67870['adiponectin-activated signaling pathway', 'endothelial tube morphogenesis', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell population proliferation', 'peptidyl-threonine phosphorylation', 'positive regulation of activin receptor signaling pathway', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'protein phosphorylation', 'protein-containing complex assembly', 'regulation of DNA binding', 'regulation of protein serine/threonine phosphatase activity', 'signal transduction', 'Wnt signaling pathway']['adiponectin-activated signaling pathway', 'endothelial tube morphogenesis', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell population proliferation', 'peptidyl-threonine phosphorylation', 'positive regulation of activin receptor signaling pathway', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'protein phosphorylation', 'protein-containing complex assembly', 'regulation of DNA binding', 'regulation of protein serine/threonine phosphatase activity', 'signal transduction', 'Wnt signaling pathway']
E3 ubiquitin-protein ligase UHRF1
344
E3 ubiquitin-protein ligase UHRF1
344
8.6
66
0.18
Q96T88Q96T88['cell cycle', 'chromatin organization', 'DNA repair', 'histone monoubiquitination', 'histone ubiquitination', 'maintenance of DNA methylation', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity', 'positive regulation of protein metabolic process', 'positive regulation of transcription by RNA polymerase II', 'protein autoubiquitination', 'protein ubiquitination', 'regulation of epithelial cell proliferation', 'ubiquitin-dependent protein catabolic process']['cell cycle', 'chromatin organization', 'DNA repair', 'histone monoubiquitination', 'histone ubiquitination', 'maintenance of DNA methylation', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity', 'positive regulation of protein metabolic process', 'positive regulation of transcription by RNA polymerase II', 'protein autoubiquitination', 'protein ubiquitination', 'regulation of epithelial cell proliferation', 'ubiquitin-dependent protein catabolic process']
Ubl carboxyl-terminal hydrolase 18
329
Ubl carboxyl-terminal hydrolase 18
336
8.3
75
0.16
Q9WTV6Q9WTV6['negative regulation of type I interferon-mediated signaling pathway', 'protein deubiquitination', 'regulation of inflammatory response', 'response to bacterium', 'response to stilbenoid', 'ubiquitin-dependent protein catabolic process']['negative regulation of type I interferon-mediated signaling pathway', 'protein deubiquitination', 'regulation of inflammatory response', 'response to bacterium', 'response to stilbenoid', 'ubiquitin-dependent protein catabolic process']
Acyl-protein thioesterase 1
173
Acyl-protein thioesterase 1
173
8.6
56
0.21
O75608O75608['fatty acid metabolic process', 'negative regulation of Golgi to plasma membrane protein transport', 'protein depalmitoylation']['fatty acid metabolic process', 'negative regulation of Golgi to plasma membrane protein transport', 'protein depalmitoylation']
Inhibin beta A chain
425
Inhibin beta A chain
390
9.9
77
0.13
P08476P08476['activin receptor signaling pathway', 'cell differentiation', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular response to cholesterol', 'cellular response to follicle-stimulating hormone stimulus', 'defense response', 'endodermal cell differentiation', 'erythrocyte differentiation', 'extrinsic apoptotic signaling pathway', 'eyelid development in camera-type eye', 'GABAergic neuron differentiation', 'hair follicle development', 'hematopoietic progenitor cell differentiation', 'hemoglobin biosynthetic process', 'male gonad development', 'mesodermal cell differentiation', 'multicellular organism aging', 'negative regulation of B cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of follicle-stimulating hormone secretion', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of interferon-gamma production', 'negative regulation of macrophage differentiation', 'negative regulation of phosphorylation', 'nervous system development', 'odontogenesis', 'ovarian follicle development', 'positive regulation of erythrocyte differentiation', 'positive regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'positive regulation of follicle-stimulating hormone secretion', 'positive regulation of gene expression', 'positive regulation of ovulation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein metabolic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'progesterone secretion', 'regulation of follicle-stimulating hormone secretion', 'regulation of transcription by RNA polymerase II', 'response to xenobiotic stimulus', 'roof of mouth development', 'SMAD protein signal transduction', 'striatal medium spiny neuron differentiation', 'transcription by RNA polymerase II']['activin receptor signaling pathway', 'cell differentiation', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular response to cholesterol', 'cellular response to follicle-stimulating hormone stimulus', 'defense response', 'endodermal cell differentiation', 'erythrocyte differentiation', 'extrinsic apoptotic signaling pathway', 'eyelid development in camera-type eye', 'GABAergic neuron differentiation', 'hair follicle development', 'hematopoietic progenitor cell differentiation', 'hemoglobin biosynthetic process', 'male gonad development', 'mesodermal cell differentiation', 'multicellular organism aging', 'negative regulation of B cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of follicle-stimulating hormone secretion', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of interferon-gamma production', 'negative regulation of macrophage differentiation', 'negative regulation of phosphorylation', 'nervous system development', 'odontogenesis', 'ovarian follicle development', 'positive regulation of erythrocyte differentiation', 'positive regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'positive regulation of follicle-stimulating hormone secretion', 'positive regulation of gene expression', 'positive regulation of ovulation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein metabolic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'progesterone secretion', 'regulation of follicle-stimulating hormone secretion', 'regulation of transcription by RNA polymerase II', 'response to xenobiotic stimulus', 'roof of mouth development', 'SMAD protein signal transduction', 'striatal medium spiny neuron differentiation', 'transcription by RNA polymerase II']
Albumin
537
Albumin
537
9.9
75
0.13
P02769P02769['cellular response to starvation', 'maintenance of mitochondrion location', 'negative regulation of apoptotic process']['cellular response to starvation', 'maintenance of mitochondrion location', 'negative regulation of apoptotic process']
Adrenodoxin, mitochondrial
112
Adrenodoxin, mitochondrial
112
8.3
89
0.14
P10109P10109['cellular response to cAMP', 'cellular response to forskolin', 'cholesterol metabolic process', 'electron transport chain', 'hormone biosynthetic process', 'P450-containing electron transport chain', 'positive regulation of oxidoreductase activity', 'steroid biosynthetic process']['cellular response to cAMP', 'cellular response to forskolin', 'cholesterol metabolic process', 'electron transport chain', 'hormone biosynthetic process', 'P450-containing electron transport chain', 'positive regulation of oxidoreductase activity', 'steroid biosynthetic process']
Splicing factor 3B subunit 3
112
Splicing factor 3B subunit 5
41
9.9
85
0.12
Q15393Q9BWJ5['histone H3 acetylation', 'monoubiquitinated histone deubiquitination', 'monoubiquitinated histone H2A deubiquitination', 'mRNA splicing, via spliceosome', 'negative regulation of protein catabolic process', 'positive regulation of transcription, DNA-templated', 'regulation of DNA repair', 'regulation of RNA splicing', 'RNA splicing', 'RNA splicing, via transesterification reactions', 'U2-type prespliceosome assembly']['histone H3 acetylation', 'monoubiquitinated histone deubiquitination', 'monoubiquitinated histone H2A deubiquitination', 'mRNA splicing, via spliceosome', 'positive regulation of transcription, DNA-templated', 'regulation of DNA repair', 'regulation of RNA splicing', 'U2-type prespliceosome assembly']
Serine/threonine-protein kinase TBK1
91
Serine/threonine-protein kinase TBK1
558
9.9
51
0.2
Q9UHD2Q9UHD2['activation of innate immune response', 'defense response to Gram-positive bacterium', 'defense response to virus', 'dendritic cell proliferation', 'I-kappaB kinase/NF-kappaB signaling', 'inflammatory response', 'innate immune response', 'negative regulation of gene expression', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interferon-alpha production', 'positive regulation of interferon-beta production', 'positive regulation of macroautophagy', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of type I interferon production', 'positive regulation of type I interferon-mediated signaling pathway', 'positive regulation of xenophagy', 'protein phosphorylation', 'regulation of neuron death', 'regulation of type I interferon production', 'response to virus', 'type I interferon signaling pathway']['activation of innate immune response', 'defense response to Gram-positive bacterium', 'defense response to virus', 'dendritic cell proliferation', 'I-kappaB kinase/NF-kappaB signaling', 'inflammatory response', 'innate immune response', 'negative regulation of gene expression', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interferon-alpha production', 'positive regulation of interferon-beta production', 'positive regulation of macroautophagy', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of type I interferon production', 'positive regulation of type I interferon-mediated signaling pathway', 'positive regulation of xenophagy', 'protein phosphorylation', 'regulation of neuron death', 'regulation of type I interferon production', 'response to virus', 'type I interferon signaling pathway']
Caspase-7
70
Caspase-7
246
9.9
72
0.14
P55210P55210['apoptotic process', 'cellular response to staurosporine', 'execution phase of apoptosis', 'extrinsic apoptotic signaling pathway', 'fibroblast apoptotic process', 'heart development', 'inflammatory response', 'intrinsic apoptotic signaling pathway', 'neuron apoptotic process', 'positive regulation of apoptotic process', 'protein processing', 'proteolysis', 'response to UV']['apoptotic process', 'cellular response to staurosporine', 'execution phase of apoptosis', 'extrinsic apoptotic signaling pathway', 'fibroblast apoptotic process', 'heart development', 'inflammatory response', 'intrinsic apoptotic signaling pathway', 'neuron apoptotic process', 'positive regulation of apoptotic process', 'protein processing', 'proteolysis', 'response to UV']
Estrogen receptor
237
Estrogen receptor
227
8.7
74
0.16
P03372P03372['androgen metabolic process', 'antral ovarian follicle growth', 'cellular response to estradiol stimulus', 'cellular response to estrogen stimulus', 'chromatin remodeling', 'epithelial cell development', 'epithelial cell proliferation involved in mammary gland duct elongation', 'fibroblast proliferation', 'intracellular estrogen receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'male gonad development', 'mammary gland alveolus development', 'mammary gland branching involved in pregnancy', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of gene expression', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of miRNA maturation', 'negative regulation of transcription by RNA polymerase II', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of fibroblast proliferation', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of phospholipase C activity', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis', 'prostate epithelial cord elongation', 'protein localization to chromatin', 'regulation of branching involved in prostate gland morphogenesis', 'regulation of epithelial cell apoptotic process', 'regulation of inflammatory response', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to estradiol', 'response to estrogen', 'signal transduction', 'stem cell differentiation', 'transcription by RNA polymerase II', 'uterus development', 'vagina development']['androgen metabolic process', 'antral ovarian follicle growth', 'cellular response to estradiol stimulus', 'cellular response to estrogen stimulus', 'chromatin remodeling', 'epithelial cell development', 'epithelial cell proliferation involved in mammary gland duct elongation', 'fibroblast proliferation', 'intracellular estrogen receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'male gonad development', 'mammary gland alveolus development', 'mammary gland branching involved in pregnancy', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of gene expression', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of miRNA maturation', 'negative regulation of transcription by RNA polymerase II', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of fibroblast proliferation', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of phospholipase C activity', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis', 'prostate epithelial cord elongation', 'protein localization to chromatin', 'regulation of branching involved in prostate gland morphogenesis', 'regulation of epithelial cell apoptotic process', 'regulation of inflammatory response', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to estradiol', 'response to estrogen', 'signal transduction', 'stem cell differentiation', 'transcription by RNA polymerase II', 'uterus development', 'vagina development']
Properdin
89
Properdin
391
9.9
60
0.17
P27918P27918['complement activation', 'complement activation, alternative pathway', 'defense response to bacterium', 'immune response', 'positive regulation of immune response', 'positive regulation of opsonization']['complement activation', 'complement activation, alternative pathway', 'defense response to bacterium', 'immune response', 'positive regulation of immune response', 'positive regulation of opsonization']
Threonine aspartase 1
271
Threonine aspartase 1
271
8.2
99
0.12
Q9H6P5Q9H6P5['positive regulation of transcription, DNA-templated', 'protein maturation', 'proteolysis']['positive regulation of transcription, DNA-templated', 'protein maturation', 'proteolysis']
APOBEC3H
88
APOBEC3H
116
8.6
58
0.2
B7TQM6B7TQM6[][]
Sequestosome-1
154
Sequestosome-1
151
8.6
70
0.17
Q13501Q13501['aggrephagy', 'apoptotic process', 'autophagy', 'autophagy of mitochondrion', 'brown fat cell proliferation', 'cell differentiation', 'endosomal transport', 'endosome organization', 'energy homeostasis', 'immune system process', 'intracellular signal transduction', 'macroautophagy', 'mitophagy', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of apoptotic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'protein import into nucleus', 'protein localization', 'protein localization to perinuclear region of cytoplasm', 'protein phosphorylation', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of mitochondrion organization', 'regulation of protein complex stability', 'regulation of Ras protein signal transduction', 'response to ischemia', 'response to mitochondrial depolarisation', 'selective autophagy', 'temperature homeostasis', 'transcription by RNA polymerase II', 'ubiquitin-dependent protein catabolic process']['aggrephagy', 'apoptotic process', 'autophagy', 'autophagy of mitochondrion', 'brown fat cell proliferation', 'cell differentiation', 'endosomal transport', 'endosome organization', 'energy homeostasis', 'immune system process', 'intracellular signal transduction', 'macroautophagy', 'mitophagy', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of apoptotic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'protein import into nucleus', 'protein localization', 'protein localization to perinuclear region of cytoplasm', 'protein phosphorylation', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of mitochondrion organization', 'regulation of protein complex stability', 'regulation of Ras protein signal transduction', 'response to ischemia', 'response to mitochondrial depolarisation', 'selective autophagy', 'temperature homeostasis', 'transcription by RNA polymerase II', 'ubiquitin-dependent protein catabolic process']
Androgen receptor
584
Androgen receptor
594
8.6
73
0.16
P15207P15207['activation of prostate induction by androgen receptor signaling pathway', 'androgen receptor signaling pathway', 'animal organ formation', 'cellular response to estrogen stimulus', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to testosterone stimulus', 'copulation', 'epithelial cell differentiation involved in prostate gland development', 'epithelial cell morphogenesis', 'fertilization', 'in utero embryonic development', 'intracellular estrogen receptor signaling pathway', 'intracellular receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lateral sprouting involved in mammary gland duct morphogenesis', 'Leydig cell differentiation', 'male courtship behavior', 'male genitalia morphogenesis', 'male gonad development', 'male sex differentiation', 'male somatic sex determination', 'mammary gland alveolus development', 'morphogenesis of an epithelial fold', 'multicellular organism growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of integrin biosynthetic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell proliferation involved in prostate gland development', 'positive regulation of gene expression', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of integrin biosynthetic process', 'positive regulation of intracellular estrogen receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of penile erection', 'positive regulation of phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase III', 'positive regulation of transcription, DNA-templated', 'prostate gland epithelium morphogenesis', 'prostate gland growth', 'regulation of developmental growth', 'regulation of gene expression', 'regulation of prostatic bud formation', 'regulation of protein localization to plasma membrane', 'regulation of systemic arterial blood pressure', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'reproductive behavior', 'reproductive structure development', 'reproductive system development', 'response to estradiol', 'response to insulin', 'response to testosterone', 'seminiferous tubule development', 'single fertilization', 'skeletal muscle hypertrophy', 'spermatogenesis', 'tertiary branching involved in mammary gland duct morphogenesis']['activation of prostate induction by androgen receptor signaling pathway', 'androgen receptor signaling pathway', 'animal organ formation', 'cellular response to estrogen stimulus', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to testosterone stimulus', 'copulation', 'epithelial cell differentiation involved in prostate gland development', 'epithelial cell morphogenesis', 'fertilization', 'in utero embryonic development', 'intracellular estrogen receptor signaling pathway', 'intracellular receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lateral sprouting involved in mammary gland duct morphogenesis', 'Leydig cell differentiation', 'male courtship behavior', 'male genitalia morphogenesis', 'male gonad development', 'male sex differentiation', 'male somatic sex determination', 'mammary gland alveolus development', 'morphogenesis of an epithelial fold', 'multicellular organism growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of integrin biosynthetic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell proliferation involved in prostate gland development', 'positive regulation of gene expression', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of integrin biosynthetic process', 'positive regulation of intracellular estrogen receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of penile erection', 'positive regulation of phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase III', 'positive regulation of transcription, DNA-templated', 'prostate gland epithelium morphogenesis', 'prostate gland growth', 'regulation of developmental growth', 'regulation of gene expression', 'regulation of prostatic bud formation', 'regulation of protein localization to plasma membrane', 'regulation of systemic arterial blood pressure', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'reproductive behavior', 'reproductive structure development', 'reproductive system development', 'response to estradiol', 'response to insulin', 'response to testosterone', 'seminiferous tubule development', 'single fertilization', 'skeletal muscle hypertrophy', 'spermatogenesis', 'tertiary branching involved in mammary gland duct morphogenesis']
Anionic trypsin-2
64
Pancreatic trypsin inhibitor
73
10.0
83
0.12
P00763P00974['collagen catabolic process', 'digestion', 'proteolysis', 'response to nutrient']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Complement C5
731
Complement C5
731
8.6
85
0.14
P01031P01031['cell surface receptor signaling pathway', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'G protein-coupled receptor signaling pathway', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']['cell surface receptor signaling pathway', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'G protein-coupled receptor signaling pathway', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']
Poly [ADP-ribose] polymerase tankyrase-1
1245
Poly [ADP-ribose] polymerase tankyrase-1
1242
8.3
63
0.19
O95271O95271['cell division', 'mitotic spindle organization', 'mRNA transport', 'negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric', 'negative regulation of telomere maintenance via telomere lengthening', 'negative regulation of telomeric DNA binding', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of telomerase activity', 'positive regulation of telomere capping', 'positive regulation of telomere maintenance via telomerase', 'positive regulation of transcription by RNA polymerase II', 'protein ADP-ribosylation', 'protein auto-ADP-ribosylation', 'protein localization to chromosome, telomeric region', 'protein poly-ADP-ribosylation', 'protein polyubiquitination', 'protein transport', 'regulation of telomere maintenance via telomerase', 'spindle assembly', 'Wnt signaling pathway']['cell division', 'mitotic spindle organization', 'mRNA transport', 'negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric', 'negative regulation of telomere maintenance via telomere lengthening', 'negative regulation of telomeric DNA binding', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of telomerase activity', 'positive regulation of telomere capping', 'positive regulation of telomere maintenance via telomerase', 'positive regulation of transcription by RNA polymerase II', 'protein ADP-ribosylation', 'protein auto-ADP-ribosylation', 'protein localization to chromosome, telomeric region', 'protein poly-ADP-ribosylation', 'protein polyubiquitination', 'protein transport', 'regulation of telomere maintenance via telomerase', 'spindle assembly', 'Wnt signaling pathway']
Mothers against decapentaplegic homolog 2
362
Zinc finger FYVE domain-containing protein 9
783
8.6
74
0.16
Q15796O95405['activin receptor signaling pathway', 'adrenal gland development', 'anatomical structure morphogenesis', 'anterior/posterior pattern specification', 'BMP signaling pathway', 'cell differentiation', 'cell fate commitment', 'common-partner SMAD protein phosphorylation', 'embryonic cranial skeleton morphogenesis', 'embryonic foregut morphogenesis', 'endoderm formation', 'gastrulation', 'in utero embryonic development', 'insulin secretion', 'intracellular signal transduction', 'lung development', 'mesoderm formation', 'negative regulation of cell population proliferation', 'negative regulation of transcription, DNA-templated', 'nodal signaling pathway', 'organ growth', 'pancreas development', 'paraxial mesoderm morphogenesis', 'pericardium development', 'positive regulation of BMP signaling pathway', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of gene expression', 'positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'post-embryonic development', 'primary miRNA processing', 'regulation of binding', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to glucose', 'secondary palate development', 'signal transduction involved in regulation of gene expression', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transcription, DNA-templated', 'transforming growth factor beta receptor signaling pathway', 'ureteric bud development', 'wound healing', 'zygotic specification of dorsal/ventral axis']['endocytosis', 'endosomal transport', 'transforming growth factor beta receptor signaling pathway']
Toll-like receptor 10
706
Toll-like receptor 10
706
8.6
62
0.19
Q9BXR5Q9BXR5['immune response', 'inflammatory response', 'innate immune response', 'MyD88-dependent toll-like receptor signaling pathway', 'positive regulation of inflammatory response', 'regulation of cytokine production', 'toll-like receptor 10 signaling pathway', 'toll-like receptor signaling pathway']['immune response', 'inflammatory response', 'innate immune response', 'MyD88-dependent toll-like receptor signaling pathway', 'positive regulation of inflammatory response', 'regulation of cytokine production', 'toll-like receptor 10 signaling pathway', 'toll-like receptor signaling pathway']
Trypsin-3
121
Protein AMBP
296
8.6
93
0.13
P35030P02760['antimicrobial humoral response', 'digestion', 'endothelial cell migration', 'proteolysis', 'zymogen activation']['cell adhesion', 'cellular oxidant detoxification', 'cellular response to reactive oxygen species', 'cytochrome c metabolic process', 'female pregnancy', 'heme catabolic process', 'hemoglobin metabolic process', 'negative regulation of immune response', 'negative regulation of JNK cascade', 'protein catabolic process']
Guanidinoacetate N-methyltransferase
220
Guanidinoacetate N-methyltransferase
220
9.9
64
0.16
P10868P10868['animal organ morphogenesis', 'creatine biosynthetic process', 'embryonic liver development', 'methylation', 'regulation of multicellular organism growth', 'S-adenosylhomocysteine metabolic process', 'S-adenosylmethionine metabolic process', 'spermatogenesis']['animal organ morphogenesis', 'creatine biosynthetic process', 'embryonic liver development', 'methylation', 'regulation of multicellular organism growth', 'S-adenosylhomocysteine metabolic process', 'S-adenosylmethionine metabolic process', 'spermatogenesis']
Coatomer subunit epsilon
34
Coatomer subunit alpha
975
10.0
72
0.14
Q28104Q27954['endoplasmic reticulum to Golgi vesicle-mediated transport', 'intra-Golgi vesicle-mediated transport', 'protein localization to axon', 'protein transport', 'retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum']['endoplasmic reticulum to Golgi vesicle-mediated transport', 'intra-Golgi vesicle-mediated transport', 'intracellular protein transport', 'retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum']
Mothers against decapentaplegic homolog 3
320
Zinc finger FYVE domain-containing protein 9
783
8.7
73
0.16
P84022O95405['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'activin receptor signaling pathway', 'adrenal gland development', 'anatomical structure morphogenesis', 'BMP signaling pathway', 'cell differentiation', 'cell-cell junction organization', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'developmental growth', 'embryonic cranial skeleton morphogenesis', 'embryonic foregut morphogenesis', 'embryonic pattern specification', 'endoderm development', 'extrinsic apoptotic signaling pathway', 'heart looping', 'immune response', 'immune system development', 'in utero embryonic development', 'JNK cascade', 'lens fiber cell differentiation', 'liver development', 'mesoderm formation', 'negative regulation of apoptotic process', 'negative regulation of cardiac muscle hypertrophy in response to stress', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cytosolic calcium ion concentration', 'negative regulation of fat cell differentiation', 'negative regulation of inflammatory response', 'negative regulation of lung blood pressure', 'negative regulation of osteoblast differentiation', 'negative regulation of osteoblast proliferation', 'negative regulation of protein catabolic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of wound healing', 'nodal signaling pathway', 'osteoblast development', 'paraxial mesoderm morphogenesis', 'pericardium development', 'positive regulation of alkaline phosphatase activity', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cell migration', 'positive regulation of chondrocyte differentiation', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of extracellular matrix assembly', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of interleukin-1 beta production', 'positive regulation of miRNA transcription', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of positive chemotaxis', 'positive regulation of protein import into nucleus', 'positive regulation of stress fiber assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta3 production', 'primary miRNA processing', 'protein stabilization', 'regulation of binding', 'regulation of epithelial cell proliferation', 'regulation of immune response', 'regulation of miRNA transcription', 'regulation of striated muscle tissue development', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'signal transduction involved in regulation of gene expression', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'somitogenesis', 'T cell activation', 'thyroid gland development', 'transdifferentiation', 'transforming growth factor beta receptor signaling pathway', 'ureteric bud development', 'wound healing']['endocytosis', 'endosomal transport', 'transforming growth factor beta receptor signaling pathway']
Urokinase plasminogen activator surface receptor
98
Urokinase plasminogen activator surface receptor
67
9.9
64
0.16
Q03405Q03405['blood coagulation', 'chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'negative regulation of intrinsic apoptotic signaling pathway', 'positive regulation of DNA binding', 'positive regulation of epidermal growth factor receptor signaling pathway', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of protein phosphorylation', 'positive regulation of release of cytochrome c from mitochondria', 'regulation of cell adhesion', 'regulation of fibrinolysis', 'regulation of plasminogen activation', 'regulation of proteolysis', 'signal transduction', 'urokinase plasminogen activator signaling pathway']['blood coagulation', 'chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'negative regulation of intrinsic apoptotic signaling pathway', 'positive regulation of DNA binding', 'positive regulation of epidermal growth factor receptor signaling pathway', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of protein phosphorylation', 'positive regulation of release of cytochrome c from mitochondria', 'regulation of cell adhesion', 'regulation of fibrinolysis', 'regulation of plasminogen activation', 'regulation of proteolysis', 'signal transduction', 'urokinase plasminogen activator signaling pathway']
Glutamate receptor 2
78
Glutamate receptor 3
85
8.2
73
0.17
P19491P19492['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']['regulation of receptor recycling', 'response to fungicide', 'response to lithium ion']
PRSS3 protein
52
Amyloid beta precursor like protein 2
343
8.7
79
0.15
Q8N2U3Q06481['proteolysis']['axonogenesis', 'central nervous system development', 'G protein-coupled receptor signaling pathway', 'regulation of cellular protein metabolic process']
Vasopressin-neurophysin 2-copeptin
65
Vasopressin-neurophysin 2-copeptin
110
10.0
102
0.1
P01180P01180['vasoconstriction']['vasoconstriction']
Suppressor of cytokine signaling 2
167
Elongin-C
112
8.7
nan
nan
O14508Q15369['cellular response to hormone stimulus', 'growth hormone receptor signaling pathway', 'intracellular signal transduction', 'lactation', 'mammary gland alveolus development', 'negative regulation of apoptotic process', 'negative regulation of multicellular organism growth', 'negative regulation of receptor signaling pathway via JAK-STAT', 'phosphatidylinositol phosphate biosynthetic process', 'positive regulation of neuron differentiation', 'protein ubiquitination', 'receptor signaling pathway via JAK-STAT', 'regulation of cell growth', 'regulation of signal transduction', 'response to estradiol']['protein ubiquitination', 'regulation of transcription by RNA polymerase II', 'transcription initiation from RNA polymerase II promoter', 'ubiquitin-dependent protein catabolic process']
DNA repair protein XRCC4
165
Non-homologous end joining factor IFFO1
515
8.6
37
0.31
Q13426Q0D2I5['DNA ligation involved in DNA repair', 'double-strand break repair', 'double-strand break repair via nonhomologous end joining', 'immunoglobulin V(D)J recombination', 'positive regulation of ligase activity', 'positive regulation of phosphatidylserine exposure on apoptotic cell surface', 'protein localization to site of double-strand break', 'response to X-ray']['DNA double-strand break attachment to nuclear envelope', 'double-strand break repair via nonhomologous end joining', 'protein localization to site of double-strand break']
Protein S100-A5
80
Protein S100-A5
80
8.4
72
0.16
P33763P33763[][]
Anionic trypsin-2
64
Pancreatic trypsin inhibitor
49
8.4
95
0.13
P00763P00974['collagen catabolic process', 'digestion', 'proteolysis', 'response to nutrient']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Serotransferrin
38
Serotransferrin
198
9.9
91
0.11
P02787P02787['actin filament organization', 'antibacterial humoral response', 'cellular iron ion homeostasis', 'cellular response to iron ion', 'ERK1 and ERK2 cascade', 'iron ion homeostasis', 'iron ion transport', 'osteoclast differentiation', 'positive regulation of bone resorption', 'positive regulation of cell motility', 'positive regulation of phosphorylation', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of transcription, DNA-templated', 'regulation of iron ion transport', 'regulation of protein stability', 'retina homeostasis', 'SMAD protein signal transduction']['actin filament organization', 'antibacterial humoral response', 'cellular iron ion homeostasis', 'cellular response to iron ion', 'ERK1 and ERK2 cascade', 'iron ion homeostasis', 'iron ion transport', 'osteoclast differentiation', 'positive regulation of bone resorption', 'positive regulation of cell motility', 'positive regulation of phosphorylation', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of transcription, DNA-templated', 'regulation of iron ion transport', 'regulation of protein stability', 'retina homeostasis', 'SMAD protein signal transduction']
Beta-nerve growth factor
136
Beta-nerve growth factor
136
9.9
77
0.13
P01139P01139['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'adult locomotory behavior', 'axon extension', 'circadian rhythm', 'extrinsic apoptotic signaling pathway in absence of ligand', 'extrinsic apoptotic signaling pathway via death domain receptors', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of type B pancreatic cell apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron projection development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of axon extension', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of collateral sprouting', 'positive regulation of DNA binding', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of neuron differentiation', 'positive regulation of neuron maturation', 'positive regulation of neuron projection development', 'positive regulation of neurotrophin TRK receptor signaling pathway', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein autophosphorylation', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of protein ubiquitination', 'positive regulation of Ras protein signal transduction', 'positive regulation of stem cell proliferation', 'protein phosphorylation', 'regulation of neuron differentiation', 'regulation of neurotransmitter secretion', 'regulation of release of sequestered calcium ion into cytosol', 'sensory perception of pain', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'adult locomotory behavior', 'axon extension', 'circadian rhythm', 'extrinsic apoptotic signaling pathway in absence of ligand', 'extrinsic apoptotic signaling pathway via death domain receptors', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of type B pancreatic cell apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron projection development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of axon extension', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of collateral sprouting', 'positive regulation of DNA binding', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of neuron differentiation', 'positive regulation of neuron maturation', 'positive regulation of neuron projection development', 'positive regulation of neurotrophin TRK receptor signaling pathway', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein autophosphorylation', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of protein ubiquitination', 'positive regulation of Ras protein signal transduction', 'positive regulation of stem cell proliferation', 'protein phosphorylation', 'regulation of neuron differentiation', 'regulation of neurotransmitter secretion', 'regulation of release of sequestered calcium ion into cytosol', 'sensory perception of pain', 'transmembrane receptor protein tyrosine kinase signaling pathway']
C-C motif chemokine 4
58
C-C motif chemokine 4
58
8.4
58
0.2
P13236P13236['cell adhesion', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'eosinophil chemotaxis', 'establishment or maintenance of cell polarity', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'neutrophil chemotaxis', 'positive regulation of calcium ion transport', 'positive regulation of calcium-mediated signaling', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of natural killer cell chemotaxis', 'response to toxic substance', 'response to virus', 'signal transduction']['cell adhesion', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'eosinophil chemotaxis', 'establishment or maintenance of cell polarity', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'neutrophil chemotaxis', 'positive regulation of calcium ion transport', 'positive regulation of calcium-mediated signaling', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of natural killer cell chemotaxis', 'response to toxic substance', 'response to virus', 'signal transduction']
Neurogenic locus notch homolog protein 3
1488
Neurogenic locus notch homolog protein 3
1475
9.9
91
0.11
Q9UM47Q9UM47['artery morphogenesis', 'axon guidance', 'forebrain development', 'glomerular capillary formation', 'negative regulation of neuron differentiation', 'negative regulation of transcription by RNA polymerase II', 'neuroblast differentiation', 'neuron fate commitment', 'Notch signaling pathway', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II']['artery morphogenesis', 'axon guidance', 'forebrain development', 'glomerular capillary formation', 'negative regulation of neuron differentiation', 'negative regulation of transcription by RNA polymerase II', 'neuroblast differentiation', 'neuron fate commitment', 'Notch signaling pathway', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II']
Guanidinoacetate N-methyltransferase
16
Guanidinoacetate N-methyltransferase
16
8.4
81
0.15
Q14353Q14353['animal organ morphogenesis', 'creatine biosynthetic process', 'creatine metabolic process', 'methylation', 'muscle contraction', 'regulation of multicellular organism growth', 'spermatogenesis']['animal organ morphogenesis', 'creatine biosynthetic process', 'creatine metabolic process', 'methylation', 'muscle contraction', 'regulation of multicellular organism growth', 'spermatogenesis']
3-hydroxy-3-methylglutaryl-coenzyme A reductase
561
3-hydroxy-3-methylglutaryl-coenzyme A reductase
527
9.9
67
0.15
P04035P04035['cholesterol biosynthetic process', 'coenzyme A metabolic process', 'isoprenoid biosynthetic process', 'negative regulation of amyloid-beta clearance', 'negative regulation of MAP kinase activity', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'sterol biosynthetic process', 'visual learning']['cholesterol biosynthetic process', 'coenzyme A metabolic process', 'isoprenoid biosynthetic process', 'negative regulation of amyloid-beta clearance', 'negative regulation of MAP kinase activity', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'sterol biosynthetic process', 'visual learning']
Histone deacetylase 6
1120
Histone deacetylase 6
1183
8.4
75
0.16
Q9UBN7Q9UBN7['aggresome assembly', 'autophagy', 'axonal transport of mitochondrion', 'cellular response to hydrogen peroxide', 'cellular response to misfolded protein', 'cellular response to topologically incorrect protein', 'cilium assembly', 'cilium disassembly', 'collateral sprouting', 'dendritic spine morphogenesis', 'histone deacetylation', 'Hsp90 deacetylation', 'intracellular protein transport', 'lysosome localization', 'negative regulation of hydrogen peroxide metabolic process', 'negative regulation of microtubule depolymerization', 'negative regulation of oxidoreductase activity', 'negative regulation of protein-containing complex assembly', 'negative regulation of protein-containing complex disassembly', 'negative regulation of proteolysis', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization', 'peptidyl-lysine deacetylation', 'polyubiquitinated misfolded protein transport', 'positive regulation of epithelial cell migration', 'positive regulation of hydrogen peroxide-mediated programmed cell death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of signaling receptor activity', 'protein deacetylation', 'protein destabilization', 'protein polyubiquitination', 'protein quality control for misfolded or incompletely synthesized proteins', 'protein-containing complex disassembly', 'regulation of androgen receptor signaling pathway', 'regulation of autophagy', 'regulation of autophagy of mitochondrion', 'regulation of establishment of protein localization', 'regulation of fat cell differentiation', 'regulation of gene expression, epigenetic', 'regulation of macroautophagy', 'regulation of microtubule-based movement', 'regulation of protein stability', 'response to growth factor', 'response to misfolded protein', 'tubulin deacetylation', 'ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway']['aggresome assembly', 'autophagy', 'axonal transport of mitochondrion', 'cellular response to hydrogen peroxide', 'cellular response to misfolded protein', 'cellular response to topologically incorrect protein', 'cilium assembly', 'cilium disassembly', 'collateral sprouting', 'dendritic spine morphogenesis', 'histone deacetylation', 'Hsp90 deacetylation', 'intracellular protein transport', 'lysosome localization', 'negative regulation of hydrogen peroxide metabolic process', 'negative regulation of microtubule depolymerization', 'negative regulation of oxidoreductase activity', 'negative regulation of protein-containing complex assembly', 'negative regulation of protein-containing complex disassembly', 'negative regulation of proteolysis', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization', 'peptidyl-lysine deacetylation', 'polyubiquitinated misfolded protein transport', 'positive regulation of epithelial cell migration', 'positive regulation of hydrogen peroxide-mediated programmed cell death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of signaling receptor activity', 'protein deacetylation', 'protein destabilization', 'protein polyubiquitination', 'protein quality control for misfolded or incompletely synthesized proteins', 'protein-containing complex disassembly', 'regulation of androgen receptor signaling pathway', 'regulation of autophagy', 'regulation of autophagy of mitochondrion', 'regulation of establishment of protein localization', 'regulation of fat cell differentiation', 'regulation of gene expression, epigenetic', 'regulation of macroautophagy', 'regulation of microtubule-based movement', 'regulation of protein stability', 'response to growth factor', 'response to misfolded protein', 'tubulin deacetylation', 'ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway']
Peptidoglycan recognition protein 1
28
Peptidoglycan recognition protein 1
28
8.4
71
0.17
Q9GK12Q9GK12['defense response to bacterium', 'innate immune response', 'negative regulation of cytokine production', 'peptidoglycan catabolic process']['defense response to bacterium', 'innate immune response', 'negative regulation of cytokine production', 'peptidoglycan catabolic process']
Transforming growth factor beta-3 proprotein
315
Transforming growth factor beta-3 proprotein
377
8.4
83
0.14
P10600P10600['aging', 'BMP signaling pathway', 'cell-cell junction organization', 'detection of hypoxia', 'digestive tract development', 'embryonic neurocranium morphogenesis', 'face morphogenesis', 'female pregnancy', 'frontal suture morphogenesis', 'in utero embryonic development', 'inner ear development', 'lung alveolus development', 'mammary gland development', 'negative regulation of cell population proliferation', 'negative regulation of macrophage cytokine production', 'negative regulation of neuron apoptotic process', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of vascular associated smooth muscle cell proliferation', 'odontogenesis', 'ossification involved in bone remodeling', 'positive regulation of apoptotic process', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of filopodium assembly', 'positive regulation of MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stress fiber assembly', 'positive regulation of tight junction disassembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of cell population proliferation', 'response to estrogen', 'response to hypoxia', 'response to laminar fluid shear stress', 'response to progesterone', 'salivary gland morphogenesis', 'secondary palate development', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'wound healing']['aging', 'BMP signaling pathway', 'cell-cell junction organization', 'detection of hypoxia', 'digestive tract development', 'embryonic neurocranium morphogenesis', 'face morphogenesis', 'female pregnancy', 'frontal suture morphogenesis', 'in utero embryonic development', 'inner ear development', 'lung alveolus development', 'mammary gland development', 'negative regulation of cell population proliferation', 'negative regulation of macrophage cytokine production', 'negative regulation of neuron apoptotic process', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of vascular associated smooth muscle cell proliferation', 'odontogenesis', 'ossification involved in bone remodeling', 'positive regulation of apoptotic process', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of filopodium assembly', 'positive regulation of MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stress fiber assembly', 'positive regulation of tight junction disassembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of cell population proliferation', 'response to estrogen', 'response to hypoxia', 'response to laminar fluid shear stress', 'response to progesterone', 'salivary gland morphogenesis', 'secondary palate development', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'wound healing']
Receptor tyrosine-protein kinase erbB-3
202
Receptor tyrosine-protein kinase erbB-3
202
9.9
67
0.15
P21860P21860['cranial nerve development', 'endocardial cushion development', 'ERBB2-ERBB3 signaling pathway', 'extrinsic apoptotic signaling pathway in absence of ligand', 'heart development', 'motor neuron apoptotic process', 'negative regulation of cell adhesion', 'negative regulation of motor neuron apoptotic process', 'negative regulation of neuron apoptotic process', 'negative regulation of secretion', 'negative regulation of signal transduction', 'nervous system development', 'neuron apoptotic process', 'peripheral nervous system development', 'phosphatidylinositol 3-kinase signaling', 'positive regulation of calcineurin-NFAT signaling cascade', 'positive regulation of cardiac muscle tissue development', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein tyrosine kinase activity', 'protein phosphorylation', 'regulation of cell population proliferation', 'Schwann cell differentiation', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'wound healing']['cranial nerve development', 'endocardial cushion development', 'ERBB2-ERBB3 signaling pathway', 'extrinsic apoptotic signaling pathway in absence of ligand', 'heart development', 'motor neuron apoptotic process', 'negative regulation of cell adhesion', 'negative regulation of motor neuron apoptotic process', 'negative regulation of neuron apoptotic process', 'negative regulation of secretion', 'negative regulation of signal transduction', 'nervous system development', 'neuron apoptotic process', 'peripheral nervous system development', 'phosphatidylinositol 3-kinase signaling', 'positive regulation of calcineurin-NFAT signaling cascade', 'positive regulation of cardiac muscle tissue development', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein tyrosine kinase activity', 'protein phosphorylation', 'regulation of cell population proliferation', 'Schwann cell differentiation', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'wound healing']
Ubiquitin carboxyl-terminal hydrolase MINDY-2
489
Ubiquitin carboxyl-terminal hydrolase MINDY-2
489
8.4
67
0.18
Q8NBR6Q8NBR6['protein K48-linked deubiquitination']['protein K48-linked deubiquitination']
Growth/differentiation factor 15
273
Growth/differentiation factor 15
244
8.4
81
0.15
Q99988Q99988['BMP signaling pathway', 'cell-cell signaling', 'glial cell-derived neurotrophic factor receptor signaling pathway', 'negative regulation of growth hormone receptor signaling pathway', 'negative regulation of multicellular organism growth', 'positive regulation of MAPK cascade', 'positive regulation of myoblast fusion', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein kinase B signaling', 'reduction of food intake in response to dietary excess', 'signal transduction', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['BMP signaling pathway', 'cell-cell signaling', 'glial cell-derived neurotrophic factor receptor signaling pathway', 'negative regulation of growth hormone receptor signaling pathway', 'negative regulation of multicellular organism growth', 'positive regulation of MAPK cascade', 'positive regulation of myoblast fusion', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein kinase B signaling', 'reduction of food intake in response to dietary excess', 'signal transduction', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
Prosaposin
509
Prosaposin
484
9.9
67
0.15
Q61207Q61207['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'antigen processing and presentation', 'cellular response to organic substance', 'ceramide metabolic process', 'cerebellar Purkinje cell differentiation', 'cochlea development', 'corneocyte development', 'cornified envelope assembly', 'developmental growth', 'epithelial cell differentiation involved in prostate gland development', 'galactosylceramide catabolic process', 'ganglioside GM1 transport to membrane', 'gene expression', 'glucosylceramide metabolic process', 'glycolipid metabolic process', 'inclusion body assembly', 'intracellular protein transport', 'lysosomal protein catabolic process', 'lysosomal transport', 'membrane lipid metabolic process', 'micturition', 'myelination', 'negative regulation of hydrogen peroxide-induced cell death', 'nervous system process', 'neuromuscular process controlling balance', 'NK T cell differentiation', 'positive regulation of beta-galactosidase activity', 'positive regulation of hydrolase activity', 'positive regulation of MAPK cascade', 'prostate gland growth', 'protein secretion', 'regulation of lipid metabolic process', 'regulation of MAPK cascade', 'sensory perception of sound', 'sphingolipid metabolic process', 'walking behavior']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'antigen processing and presentation', 'cellular response to organic substance', 'ceramide metabolic process', 'cerebellar Purkinje cell differentiation', 'cochlea development', 'corneocyte development', 'cornified envelope assembly', 'developmental growth', 'epithelial cell differentiation involved in prostate gland development', 'galactosylceramide catabolic process', 'ganglioside GM1 transport to membrane', 'gene expression', 'glucosylceramide metabolic process', 'glycolipid metabolic process', 'inclusion body assembly', 'intracellular protein transport', 'lysosomal protein catabolic process', 'lysosomal transport', 'membrane lipid metabolic process', 'micturition', 'myelination', 'negative regulation of hydrogen peroxide-induced cell death', 'nervous system process', 'neuromuscular process controlling balance', 'NK T cell differentiation', 'positive regulation of beta-galactosidase activity', 'positive regulation of hydrolase activity', 'positive regulation of MAPK cascade', 'prostate gland growth', 'protein secretion', 'regulation of lipid metabolic process', 'regulation of MAPK cascade', 'sensory perception of sound', 'sphingolipid metabolic process', 'walking behavior']
Ribonuclease pancreatic
91
Ribonuclease inhibitor
404
9.9
63
0.16
P61823P10775['defense response to Gram-positive bacterium', 'RNA phosphodiester bond hydrolysis']['regulation of angiogenesis']
ABO glycosyltransferase
70
ABO glycosyltransferase
70
9.9
70
0.14
Q70V26Q70V26['carbohydrate metabolic process']['carbohydrate metabolic process']
Glycoprotein hormones alpha chain
83
Follitropin subunit beta
105
9.9
78
0.13
Q96QJ4P01225[]['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Placenta growth factor
77
Placenta growth factor
87
8.4
65
0.18
P49763P49763['animal organ regeneration', 'cell differentiation', 'cell-cell signaling', 'cellular response to hormone stimulus', 'female pregnancy', 'induction of positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell proliferation', 'positive regulation of mast cell chemotaxis', 'positive regulation of protein phosphorylation', 'response to hypoxia', 'response to xenobiotic stimulus', 'signal transduction', 'sprouting angiogenesis', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor signaling pathway']['animal organ regeneration', 'cell differentiation', 'cell-cell signaling', 'cellular response to hormone stimulus', 'female pregnancy', 'induction of positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell proliferation', 'positive regulation of mast cell chemotaxis', 'positive regulation of protein phosphorylation', 'response to hypoxia', 'response to xenobiotic stimulus', 'signal transduction', 'sprouting angiogenesis', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor signaling pathway']
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
492
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
488
8.4
73
0.16
Q9Y233Q9Y233['cAMP catabolic process', 'cGMP catabolic process', 'negative regulation of cGMP-mediated signaling', 'signal transduction']['cAMP catabolic process', 'cGMP catabolic process', 'negative regulation of cGMP-mediated signaling', 'signal transduction']
Annexin A2
9
Protein S100-A10
83
8.4
63
0.19
P07356P60903['angiogenesis', 'body fluid secretion', 'collagen fibril organization', 'fibrinolysis', 'membrane raft assembly', 'mRNA transcription by RNA polymerase II', 'negative regulation of low-density lipoprotein particle receptor catabolic process', 'negative regulation of receptor internalization', 'osteoclast development', 'positive regulation of binding', 'positive regulation of exocytosis', 'positive regulation of fibroblast proliferation', 'positive regulation of low-density lipoprotein particle clearance', 'positive regulation of low-density lipoprotein particle receptor binding', 'positive regulation of low-density lipoprotein receptor activity', 'positive regulation of plasma membrane repair', 'positive regulation of plasminogen activation', 'positive regulation of protein phosphorylation', 'positive regulation of receptor recycling', 'positive regulation of receptor-mediated endocytosis involved in cholesterol transport', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vacuole organization', 'positive regulation of vesicle fusion', 'protein localization to plasma membrane', 'regulation of neurogenesis', 'vesicle budding from membrane']['membrane raft assembly', 'mRNA transcription by RNA polymerase II', 'positive regulation of binding', 'positive regulation of exocytosis', 'positive regulation of focal adhesion assembly', 'positive regulation of GTPase activity', 'positive regulation of plasma membrane repair', 'positive regulation of plasminogen activation', 'positive regulation of stress fiber assembly', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of transcription by RNA polymerase II', 'protein localization to plasma membrane', 'regulation of neurogenesis', 'vesicle budding from membrane']
Growth/differentiation factor 11
371
Growth/differentiation factor 11
372
8.4
82
0.15
O95390O95390['amacrine cell differentiation', 'camera-type eye morphogenesis', 'cell population proliferation', 'mesoderm development', 'metanephros development', 'negative regulation of amacrine cell differentiation', 'negative regulation of cell population proliferation', 'nervous system development', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'roof of mouth development', 'skeletal system development', 'SMAD protein signal transduction', 'spinal cord anterior/posterior patterning', 'type B pancreatic cell maturation', 'ureteric bud development']['amacrine cell differentiation', 'camera-type eye morphogenesis', 'cell population proliferation', 'mesoderm development', 'metanephros development', 'negative regulation of amacrine cell differentiation', 'negative regulation of cell population proliferation', 'nervous system development', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'roof of mouth development', 'skeletal system development', 'SMAD protein signal transduction', 'spinal cord anterior/posterior patterning', 'type B pancreatic cell maturation', 'ureteric bud development']
Isovaleryl-CoA dehydrogenase, mitochondrial
370
Isovaleryl-CoA dehydrogenase, mitochondrial
339
9.9
89
0.11
P26440P26440['branched-chain amino acid catabolic process', 'fatty acid beta-oxidation using acyl-CoA dehydrogenase', 'leucine catabolic process']['branched-chain amino acid catabolic process', 'fatty acid beta-oxidation using acyl-CoA dehydrogenase', 'leucine catabolic process']
Protein PML
88
Protein PML
91
8.4
65
0.18
P29590P29590['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'apoptotic process', 'branching involved in mammary gland duct morphogenesis', 'cell fate commitment', 'cellular response to interleukin-4', 'cellular response to leukemia inhibitory factor', 'cellular senescence', 'circadian regulation of gene expression', 'common-partner SMAD protein phosphorylation', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'endoplasmic reticulum calcium ion homeostasis', 'entrainment of circadian clock by photoperiod', 'extrinsic apoptotic signaling pathway', 'fibroblast migration', 'innate immune response', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'intrinsic apoptotic signaling pathway in response to oxidative stress', 'maintenance of protein location in nucleus', 'myeloid cell differentiation', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of interleukin-1 beta production', 'negative regulation of mitotic cell cycle', 'negative regulation of telomerase activity', 'negative regulation of telomere maintenance via telomerase', 'negative regulation of transcription, DNA-templated', 'negative regulation of translation in response to oxidative stress', 'negative regulation of ubiquitin-dependent protein catabolic process', 'oncogene-induced cell senescence', 'PML body organization', 'positive regulation of apoptotic process involved in mammary gland involution', 'positive regulation of defense response to virus by host', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of fibroblast proliferation', 'positive regulation of histone deacetylation', 'positive regulation of peptidyl-lysine acetylation', 'positive regulation of protein localization to chromosome, telomeric region', 'positive regulation of signal transduction by p53 class mediator', 'positive regulation of telomere maintenance', 'positive regulation of transcription, DNA-templated', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein import into nucleus', 'protein stabilization', 'protein targeting', 'protein-containing complex assembly', 'protein-containing complex localization', 'regulation of calcium ion transport into cytosol', 'regulation of cell adhesion', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of double-strand break repair', 'regulation of transcription, DNA-templated', 'response to cytokine', 'response to gamma radiation', 'response to hypoxia', 'response to UV', 'retinoic acid receptor signaling pathway', 'suppression of viral release by host', 'transforming growth factor beta receptor signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'apoptotic process', 'branching involved in mammary gland duct morphogenesis', 'cell fate commitment', 'cellular response to interleukin-4', 'cellular response to leukemia inhibitory factor', 'cellular senescence', 'circadian regulation of gene expression', 'common-partner SMAD protein phosphorylation', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'endoplasmic reticulum calcium ion homeostasis', 'entrainment of circadian clock by photoperiod', 'extrinsic apoptotic signaling pathway', 'fibroblast migration', 'innate immune response', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'intrinsic apoptotic signaling pathway in response to oxidative stress', 'maintenance of protein location in nucleus', 'myeloid cell differentiation', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of interleukin-1 beta production', 'negative regulation of mitotic cell cycle', 'negative regulation of telomerase activity', 'negative regulation of telomere maintenance via telomerase', 'negative regulation of transcription, DNA-templated', 'negative regulation of translation in response to oxidative stress', 'negative regulation of ubiquitin-dependent protein catabolic process', 'oncogene-induced cell senescence', 'PML body organization', 'positive regulation of apoptotic process involved in mammary gland involution', 'positive regulation of defense response to virus by host', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of fibroblast proliferation', 'positive regulation of histone deacetylation', 'positive regulation of peptidyl-lysine acetylation', 'positive regulation of protein localization to chromosome, telomeric region', 'positive regulation of signal transduction by p53 class mediator', 'positive regulation of telomere maintenance', 'positive regulation of transcription, DNA-templated', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein import into nucleus', 'protein stabilization', 'protein targeting', 'protein-containing complex assembly', 'protein-containing complex localization', 'regulation of calcium ion transport into cytosol', 'regulation of cell adhesion', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of double-strand break repair', 'regulation of transcription, DNA-templated', 'response to cytokine', 'response to gamma radiation', 'response to hypoxia', 'response to UV', 'retinoic acid receptor signaling pathway', 'suppression of viral release by host', 'transforming growth factor beta receptor signaling pathway']
Cathepsin B
105
Cathepsin B
187
9.9
67
0.15
P07858P07858['cellular response to thyroid hormone stimulus', 'collagen catabolic process', 'decidualization', 'epithelial cell differentiation', 'negative regulation of peptidase activity', 'proteolysis', 'proteolysis involved in protein catabolic process', 'regulation of apoptotic process', 'thyroid hormone generation', 'viral entry into host cell']['cellular response to thyroid hormone stimulus', 'collagen catabolic process', 'decidualization', 'epithelial cell differentiation', 'negative regulation of peptidase activity', 'proteolysis', 'proteolysis involved in protein catabolic process', 'regulation of apoptotic process', 'thyroid hormone generation', 'viral entry into host cell']
11-beta-hydroxysteroid dehydrogenase 1
272
11-beta-hydroxysteroid dehydrogenase 1
272
8.4
69
0.17
P28845P28845['lung development', 'steroid catabolic process']['lung development', 'steroid catabolic process']
Growth/differentiation factor 15
273
Growth/differentiation factor 15
307
9.9
82
0.12
Q99988Q99988['BMP signaling pathway', 'cell-cell signaling', 'glial cell-derived neurotrophic factor receptor signaling pathway', 'negative regulation of growth hormone receptor signaling pathway', 'negative regulation of multicellular organism growth', 'positive regulation of MAPK cascade', 'positive regulation of myoblast fusion', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein kinase B signaling', 'reduction of food intake in response to dietary excess', 'signal transduction', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['BMP signaling pathway', 'cell-cell signaling', 'glial cell-derived neurotrophic factor receptor signaling pathway', 'negative regulation of growth hormone receptor signaling pathway', 'negative regulation of multicellular organism growth', 'positive regulation of MAPK cascade', 'positive regulation of myoblast fusion', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein kinase B signaling', 'reduction of food intake in response to dietary excess', 'signal transduction', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
E3 ubiquitin-protein ligase UHRF1
321
E3 ubiquitin-protein ligase UHRF1
344
8.4
66
0.18
Q96T88Q96T88['cell cycle', 'chromatin organization', 'DNA repair', 'histone monoubiquitination', 'histone ubiquitination', 'maintenance of DNA methylation', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity', 'positive regulation of protein metabolic process', 'positive regulation of transcription by RNA polymerase II', 'protein autoubiquitination', 'protein ubiquitination', 'regulation of epithelial cell proliferation', 'ubiquitin-dependent protein catabolic process']['cell cycle', 'chromatin organization', 'DNA repair', 'histone monoubiquitination', 'histone ubiquitination', 'maintenance of DNA methylation', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity', 'positive regulation of protein metabolic process', 'positive regulation of transcription by RNA polymerase II', 'protein autoubiquitination', 'protein ubiquitination', 'regulation of epithelial cell proliferation', 'ubiquitin-dependent protein catabolic process']
Bile acid receptor
446
Bile acid receptor
446
8.4
57
0.21
Q96RI1Q96RI1['bile acid metabolic process', 'bile acid signaling pathway', 'cell differentiation', 'cell-cell junction assembly', 'cellular glucose homeostasis', 'cellular response to bile acid', 'cellular response to fatty acid', 'cellular response to lipopolysaccharide', 'cellular response to organonitrogen compound', 'cellular triglyceride homeostasis', 'cholesterol homeostasis', 'defense response to bacterium', 'fatty acid homeostasis', 'histone H3-R17 methylation', 'inflammatory response', 'innate immune response', 'intracellular bile acid receptor signaling pathway', 'intracellular receptor signaling pathway', 'negative regulation of apoptotic process', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of inflammatory response', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-1 production', 'negative regulation of interleukin-2 production', 'negative regulation of interleukin-6 production', 'negative regulation of monocyte chemotactic protein-1 production', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of tumor necrosis factor production', 'negative regulation of tumor necrosis factor-mediated signaling pathway', 'negative regulation of very-low-density lipoprotein particle remodeling', 'nitrogen catabolite activation of transcription from RNA polymerase II promoter', 'Notch signaling pathway', 'positive regulation of adipose tissue development', 'positive regulation of ammonia assimilation cycle', 'positive regulation of glutamate metabolic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of interleukin-17 production', 'positive regulation of phosphatidic acid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of bile acid biosynthetic process', 'regulation of cholesterol metabolic process', 'regulation of insulin secretion involved in cellular response to glucose stimulus', 'regulation of low-density lipoprotein particle clearance', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'regulation of urea metabolic process', 'toll-like receptor 4 signaling pathway', 'toll-like receptor 9 signaling pathway', 'transcription by RNA polymerase II']['bile acid metabolic process', 'bile acid signaling pathway', 'cell differentiation', 'cell-cell junction assembly', 'cellular glucose homeostasis', 'cellular response to bile acid', 'cellular response to fatty acid', 'cellular response to lipopolysaccharide', 'cellular response to organonitrogen compound', 'cellular triglyceride homeostasis', 'cholesterol homeostasis', 'defense response to bacterium', 'fatty acid homeostasis', 'histone H3-R17 methylation', 'inflammatory response', 'innate immune response', 'intracellular bile acid receptor signaling pathway', 'intracellular receptor signaling pathway', 'negative regulation of apoptotic process', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of inflammatory response', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-1 production', 'negative regulation of interleukin-2 production', 'negative regulation of interleukin-6 production', 'negative regulation of monocyte chemotactic protein-1 production', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of tumor necrosis factor production', 'negative regulation of tumor necrosis factor-mediated signaling pathway', 'negative regulation of very-low-density lipoprotein particle remodeling', 'nitrogen catabolite activation of transcription from RNA polymerase II promoter', 'Notch signaling pathway', 'positive regulation of adipose tissue development', 'positive regulation of ammonia assimilation cycle', 'positive regulation of glutamate metabolic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of interleukin-17 production', 'positive regulation of phosphatidic acid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of bile acid biosynthetic process', 'regulation of cholesterol metabolic process', 'regulation of insulin secretion involved in cellular response to glucose stimulus', 'regulation of low-density lipoprotein particle clearance', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'regulation of urea metabolic process', 'toll-like receptor 4 signaling pathway', 'toll-like receptor 9 signaling pathway', 'transcription by RNA polymerase II']
Malate dehydrogenase, cytoplasmic
60
Malate dehydrogenase, cytoplasmic
251
9.9
80
0.13
P11708P11708['malate metabolic process', 'NADH metabolic process', 'oxaloacetate metabolic process', 'tricarboxylic acid cycle']['malate metabolic process', 'NADH metabolic process', 'oxaloacetate metabolic process', 'tricarboxylic acid cycle']
Insulin
88
Insulin
31
8.4
55
0.22
A6XGL2A6XGL2['glucose metabolic process']['glucose metabolic process']
Chymotrypsin-like elastase family member 1
56
Elafin
109
8.4
88
0.14
P00772P19957['proteolysis']['antibacterial humoral response', 'copulation', 'innate immune response', 'peptide cross-linking']
Toll-like receptor 2
750
Toll-like receptor 2
673
8.4
73
0.16
O60603O60603['apoptotic process', 'cell activation', 'cellular response to bacterial lipopeptide', 'cellular response to diacyl bacterial lipopeptide', 'cellular response to interferon-gamma', 'cellular response to lipoteichoic acid', 'cellular response to triacyl bacterial lipopeptide', 'central nervous system myelin formation', 'defense response to Gram-positive bacterium', 'defense response to virus', 'detection of diacyl bacterial lipopeptide', 'detection of triacyl bacterial lipopeptide', 'I-kappaB phosphorylation', 'immune response', 'inflammatory response', 'innate immune response', 'learning', 'leukotriene metabolic process', 'microglia development', 'microglial cell activation', 'MyD88-dependent toll-like receptor signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of phagocytosis', 'negative regulation of synapse assembly', 'nitric oxide metabolic process', 'positive regulation of cellular response to macrophage colony-stimulating factor stimulus', 'positive regulation of chemokine production', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of interferon-beta production', 'positive regulation of interleukin-10 production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-18 production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of matrix metallopeptidase secretion', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric-oxide synthase biosynthetic process', 'positive regulation of oligodendrocyte differentiation', 'positive regulation of toll-like receptor signaling pathway', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'positive regulation of Wnt signaling pathway', 'response to fatty acid', 'response to hypoxia', 'response to insulin', 'response to progesterone', 'response to toxic substance', 'signal transduction', 'toll-like receptor 2 signaling pathway', 'toll-like receptor signaling pathway', 'toll-like receptor TLR6']['apoptotic process', 'cell activation', 'cellular response to bacterial lipopeptide', 'cellular response to diacyl bacterial lipopeptide', 'cellular response to interferon-gamma', 'cellular response to lipoteichoic acid', 'cellular response to triacyl bacterial lipopeptide', 'central nervous system myelin formation', 'defense response to Gram-positive bacterium', 'defense response to virus', 'detection of diacyl bacterial lipopeptide', 'detection of triacyl bacterial lipopeptide', 'I-kappaB phosphorylation', 'immune response', 'inflammatory response', 'innate immune response', 'learning', 'leukotriene metabolic process', 'microglia development', 'microglial cell activation', 'MyD88-dependent toll-like receptor signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of phagocytosis', 'negative regulation of synapse assembly', 'nitric oxide metabolic process', 'positive regulation of cellular response to macrophage colony-stimulating factor stimulus', 'positive regulation of chemokine production', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of interferon-beta production', 'positive regulation of interleukin-10 production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-18 production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of matrix metallopeptidase secretion', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric-oxide synthase biosynthetic process', 'positive regulation of oligodendrocyte differentiation', 'positive regulation of toll-like receptor signaling pathway', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'positive regulation of Wnt signaling pathway', 'response to fatty acid', 'response to hypoxia', 'response to insulin', 'response to progesterone', 'response to toxic substance', 'signal transduction', 'toll-like receptor 2 signaling pathway', 'toll-like receptor signaling pathway', 'toll-like receptor TLR6']
Complement C5
702
Complement C5
702
8.4
77
0.15
P06684P06684['complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']['complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']
Epidermal growth factor receptor
219
Epidermal growth factor receptor
231
9.9
81
0.12
P00533P00533['activation of phospholipase C activity', 'cell differentiation', 'cell morphogenesis', 'cell surface receptor signaling pathway', 'cell-cell adhesion', 'cellular response to amino acid stimulus', 'cellular response to cadmium ion', 'cellular response to epidermal growth factor stimulus', 'cellular response to estradiol stimulus', 'cellular response to reactive oxygen species', 'cerebral cortex cell migration', 'digestive tract morphogenesis', 'embryonic placenta development', 'epidermal growth factor receptor signaling pathway', 'epithelial cell proliferation', 'ERBB2-EGFR signaling pathway', 'eyelid development in camera-type eye', 'hair follicle development', 'learning or memory', 'morphogenesis of an epithelial fold', 'negative regulation of apoptotic process', 'negative regulation of cardiocyte differentiation', 'negative regulation of epidermal growth factor receptor signaling pathway', 'negative regulation of protein catabolic process', 'ossification', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cyclin-dependent protein serine/threonine kinase activity', 'positive regulation of DNA repair', 'positive regulation of DNA replication', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of G1/S transition of mitotic cell cycle', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of miRNA maturation', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C activity', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein insertion into membrane', 'regulation of ERK1 and ERK2 cascade', 'regulation of JNK cascade', 'regulation of nitric-oxide synthase activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of phosphatidylinositol 3-kinase signaling', 'response to UV-A', 'salivary gland morphogenesis', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of phospholipase C activity', 'cell differentiation', 'cell morphogenesis', 'cell surface receptor signaling pathway', 'cell-cell adhesion', 'cellular response to amino acid stimulus', 'cellular response to cadmium ion', 'cellular response to epidermal growth factor stimulus', 'cellular response to estradiol stimulus', 'cellular response to reactive oxygen species', 'cerebral cortex cell migration', 'digestive tract morphogenesis', 'embryonic placenta development', 'epidermal growth factor receptor signaling pathway', 'epithelial cell proliferation', 'ERBB2-EGFR signaling pathway', 'eyelid development in camera-type eye', 'hair follicle development', 'learning or memory', 'morphogenesis of an epithelial fold', 'negative regulation of apoptotic process', 'negative regulation of cardiocyte differentiation', 'negative regulation of epidermal growth factor receptor signaling pathway', 'negative regulation of protein catabolic process', 'ossification', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cyclin-dependent protein serine/threonine kinase activity', 'positive regulation of DNA repair', 'positive regulation of DNA replication', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of G1/S transition of mitotic cell cycle', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of miRNA maturation', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C activity', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein insertion into membrane', 'regulation of ERK1 and ERK2 cascade', 'regulation of JNK cascade', 'regulation of nitric-oxide synthase activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of phosphatidylinositol 3-kinase signaling', 'response to UV-A', 'salivary gland morphogenesis', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway']
PRSS3 protein
68
Pancreatic trypsin inhibitor
49
8.4
95
0.13
Q8N2U3P00974['proteolysis']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Mast/stem cell growth factor receptor Kit
673
Mast/stem cell growth factor receptor Kit
674
9.9
70
0.14
P10721P10721['actin cytoskeleton reorganization', 'B cell differentiation', 'cell chemotaxis', 'cellular response to thyroid hormone stimulus', 'cytokine-mediated signaling pathway', 'detection of mechanical stimulus involved in sensory perception of sound', 'digestive tract development', 'ectopic germ cell programmed cell death', 'embryonic hemopoiesis', 'epithelial cell proliferation', 'erythrocyte differentiation', 'erythropoietin-mediated signaling pathway', 'Fc receptor signaling pathway', 'germ cell migration', 'glycosphingolipid metabolic process', 'hematopoietic progenitor cell differentiation', 'hematopoietic stem cell migration', 'hemopoiesis', 'immature B cell differentiation', 'inflammatory response', 'intracellular signal transduction', 'Kit signaling pathway', 'lamellipodium assembly', 'lymphoid progenitor cell differentiation', 'male gonad development', 'mast cell chemotaxis', 'mast cell degranulation', 'mast cell differentiation', 'mast cell proliferation', 'megakaryocyte development', 'melanocyte adhesion', 'melanocyte differentiation', 'melanocyte migration', 'myeloid progenitor cell differentiation', 'negative regulation of developmental process', 'negative regulation of programmed cell death', 'negative regulation of reproductive process', 'ovarian follicle development', 'pigmentation', 'positive regulation of cell migration', 'positive regulation of colon smooth muscle contraction', 'positive regulation of dendritic cell cytokine production', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of kinase activity', 'positive regulation of long-term neuronal synaptic plasticity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell cytokine production', 'positive regulation of mast cell proliferation', 'positive regulation of Notch signaling pathway', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phospholipase C activity', 'positive regulation of pseudopodium assembly', 'positive regulation of pyloric antrum smooth muscle contraction', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of small intestine smooth muscle contraction', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of vascular associated smooth muscle cell differentiation', 'protein autophosphorylation', 'regulation of bile acid metabolic process', 'regulation of cell population proliferation', 'regulation of cell shape', 'response to cadmium ion', 'signal transduction', 'somatic stem cell division', 'somatic stem cell population maintenance', 'spermatid development', 'spermatogenesis', 'stem cell differentiation', 'stem cell population maintenance', 'T cell differentiation', 'tongue development', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'visual learning']['actin cytoskeleton reorganization', 'B cell differentiation', 'cell chemotaxis', 'cellular response to thyroid hormone stimulus', 'cytokine-mediated signaling pathway', 'detection of mechanical stimulus involved in sensory perception of sound', 'digestive tract development', 'ectopic germ cell programmed cell death', 'embryonic hemopoiesis', 'epithelial cell proliferation', 'erythrocyte differentiation', 'erythropoietin-mediated signaling pathway', 'Fc receptor signaling pathway', 'germ cell migration', 'glycosphingolipid metabolic process', 'hematopoietic progenitor cell differentiation', 'hematopoietic stem cell migration', 'hemopoiesis', 'immature B cell differentiation', 'inflammatory response', 'intracellular signal transduction', 'Kit signaling pathway', 'lamellipodium assembly', 'lymphoid progenitor cell differentiation', 'male gonad development', 'mast cell chemotaxis', 'mast cell degranulation', 'mast cell differentiation', 'mast cell proliferation', 'megakaryocyte development', 'melanocyte adhesion', 'melanocyte differentiation', 'melanocyte migration', 'myeloid progenitor cell differentiation', 'negative regulation of developmental process', 'negative regulation of programmed cell death', 'negative regulation of reproductive process', 'ovarian follicle development', 'pigmentation', 'positive regulation of cell migration', 'positive regulation of colon smooth muscle contraction', 'positive regulation of dendritic cell cytokine production', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of kinase activity', 'positive regulation of long-term neuronal synaptic plasticity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell cytokine production', 'positive regulation of mast cell proliferation', 'positive regulation of Notch signaling pathway', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phospholipase C activity', 'positive regulation of pseudopodium assembly', 'positive regulation of pyloric antrum smooth muscle contraction', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of small intestine smooth muscle contraction', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of vascular associated smooth muscle cell differentiation', 'protein autophosphorylation', 'regulation of bile acid metabolic process', 'regulation of cell population proliferation', 'regulation of cell shape', 'response to cadmium ion', 'signal transduction', 'somatic stem cell division', 'somatic stem cell population maintenance', 'spermatid development', 'spermatogenesis', 'stem cell differentiation', 'stem cell population maintenance', 'T cell differentiation', 'tongue development', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'visual learning']
Rab-like protein 3
41
Rab-like protein 3
41
8.4
76
0.16
Q9D4V7Q9D4V7['B cell differentiation', 'intracellular protein transport', 'natural killer cell differentiation', 'protein stabilization', 'regulation of protein lipidation', 'regulation of Ras protein signal transduction', 'T cell differentiation in thymus']['B cell differentiation', 'intracellular protein transport', 'natural killer cell differentiation', 'protein stabilization', 'regulation of protein lipidation', 'regulation of Ras protein signal transduction', 'T cell differentiation in thymus']
Proprotein convertase subtilisin/kexin type 9
378
Low-density lipoprotein receptor
329
8.4
81
0.15
Q8NBP7Q59FQ1['apoptotic process', 'cellular response to insulin stimulus', 'cellular response to starvation', 'cholesterol homeostasis', 'cholesterol metabolic process', 'kidney development', 'lipoprotein metabolic process', 'liver development', 'low-density lipoprotein particle receptor catabolic process', 'lysosomal transport', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of low-density lipoprotein particle receptor binding', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of receptor internalization', 'negative regulation of receptor recycling', 'negative regulation of receptor-mediated endocytosis involved in cholesterol transport', 'negative regulation of sodium ion transmembrane transporter activity', 'neurogenesis', 'neuron differentiation', 'phospholipid metabolic process', 'positive regulation of low-density lipoprotein particle receptor catabolic process', 'positive regulation of neuron apoptotic process', 'positive regulation of receptor internalization', 'protein autoprocessing', 'regulation of neuron apoptotic process', 'regulation of signaling receptor activity', 'triglyceride metabolic process']['amyloid-beta clearance', 'amyloid-beta clearance by cellular catabolic process', 'artery morphogenesis', 'cellular response to fatty acid', 'cellular response to low-density lipoprotein particle stimulus', 'cholesterol homeostasis', 'cholesterol import', 'cholesterol metabolic process', 'cholesterol transport', 'endocytosis', 'high-density lipoprotein particle clearance', 'intestinal cholesterol absorption', 'lipid metabolic process', 'lipoprotein catabolic process', 'long-term memory', 'low-density lipoprotein particle clearance', 'negative regulation of amyloid fibril formation', 'negative regulation of astrocyte activation', 'negative regulation of gene expression', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of microglial cell activation', 'negative regulation of protein metabolic process', 'negative regulation of receptor recycling', 'phagocytosis', 'phospholipid transport', 'plasma lipoprotein particle clearance', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of lysosomal protein catabolic process', 'positive regulation of triglyceride biosynthetic process', 'receptor-mediated endocytosis', 'receptor-mediated endocytosis involved in cholesterol transport', 'regulation of cholesterol metabolic process', 'regulation of phosphatidylcholine catabolic process', 'regulation of protein metabolic process', 'response to caloric restriction']
Growth/differentiation factor 11
345
Growth/differentiation factor 11
371
8.4
70
0.17
O95390O95390['amacrine cell differentiation', 'camera-type eye morphogenesis', 'cell population proliferation', 'mesoderm development', 'metanephros development', 'negative regulation of amacrine cell differentiation', 'negative regulation of cell population proliferation', 'nervous system development', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'roof of mouth development', 'skeletal system development', 'SMAD protein signal transduction', 'spinal cord anterior/posterior patterning', 'type B pancreatic cell maturation', 'ureteric bud development']['amacrine cell differentiation', 'camera-type eye morphogenesis', 'cell population proliferation', 'mesoderm development', 'metanephros development', 'negative regulation of amacrine cell differentiation', 'negative regulation of cell population proliferation', 'nervous system development', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'roof of mouth development', 'skeletal system development', 'SMAD protein signal transduction', 'spinal cord anterior/posterior patterning', 'type B pancreatic cell maturation', 'ureteric bud development']
C-type lectin domain family 4 member A
222
C-type lectin domain family 4 member A
222
8.4
98
0.12
Q9UMR7Q9UMR7['adaptive immune response', 'antifungal innate immune response', 'antigen processing and presentation of exogenous peptide antigen via MHC class I', 'CD8-positive, alpha-beta T cell activation', 'cell adhesion', 'cell surface receptor signaling pathway', 'immune response', 'negative regulation of cytokine production', 'negative regulation of tumor necrosis factor production', 'plasmacytoid dendritic cell antigen processing and presentation']['adaptive immune response', 'antifungal innate immune response', 'antigen processing and presentation of exogenous peptide antigen via MHC class I', 'CD8-positive, alpha-beta T cell activation', 'cell adhesion', 'cell surface receptor signaling pathway', 'immune response', 'negative regulation of cytokine production', 'negative regulation of tumor necrosis factor production', 'plasmacytoid dendritic cell antigen processing and presentation']
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
271
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
271
9.9
71
0.14
Q10588Q10588['humoral immune response', 'positive regulation of B cell proliferation', 'positive regulation of cell population proliferation', 'regulation of actin cytoskeleton organization', 'regulation of calcium-mediated signaling', 'regulation of cell-matrix adhesion', 'regulation of cellular extravasation', 'regulation of inflammatory response', 'regulation of integrin-mediated signaling pathway', 'regulation of neutrophil chemotaxis', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of superoxide metabolic process', 'signal transduction']['humoral immune response', 'positive regulation of B cell proliferation', 'positive regulation of cell population proliferation', 'regulation of actin cytoskeleton organization', 'regulation of calcium-mediated signaling', 'regulation of cell-matrix adhesion', 'regulation of cellular extravasation', 'regulation of inflammatory response', 'regulation of integrin-mediated signaling pathway', 'regulation of neutrophil chemotaxis', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of superoxide metabolic process', 'signal transduction']
Transportin-3
912
Transportin-3
793
8.6
69
0.17
Q9Y5L0Q9Y5L0['protein import into nucleus']['protein import into nucleus']
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
279
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
279
8.3
96
0.13
P11181P11181['branched-chain amino acid catabolic process']['branched-chain amino acid catabolic process']
Endothelin-1
63
Endothelin-1
63
8.4
52
0.23
P05305P05305['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'artery smooth muscle contraction', 'axon extension', 'axonogenesis involved in innervation', 'body fluid secretion', 'branching involved in blood vessel morphogenesis', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cardiac neural crest cell migration involved in outflow tract morphogenesis', 'cartilage development', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to calcium ion', 'cellular response to fatty acid', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to human chorionic gonadotropin stimulus', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to luteinizing hormone stimulus', 'cellular response to mineralocorticoid stimulus', 'cellular response to organic substance', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to xenobiotic stimulus', 'dorsal/ventral pattern formation', 'embryonic heart tube development', 'endothelin receptor signaling pathway', 'endothelin receptor signaling pathway involved in heart process', 'epithelial fluid transport', 'ERK1 and ERK2 cascade', 'G protein-coupled receptor signaling pathway', 'histamine secretion', 'I-kappaB kinase/NF-kappaB signaling', 'in utero embryonic development', 'inositol phosphate-mediated signaling', 'leukocyte activation', 'maternal process involved in parturition', 'meiotic cell cycle process involved in oocyte maturation', 'membrane depolarization', 'middle ear morphogenesis', 'mitochondrion organization', 'multicellular organism aging', 'negative regulation of blood coagulation', 'negative regulation of gene expression', 'negative regulation of hormone secretion', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein metabolic process', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'neural crest cell fate commitment', 'nitric oxide transport', 'noradrenergic neuron differentiation', 'peptide hormone secretion', 'pharyngeal arch artery morphogenesis', 'phosphatidylinositol 3-kinase signaling', 'phospholipase D-activating G protein-coupled receptor signaling pathway', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cation channel activity', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell size', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell migration', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of JUN kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of odontogenesis', 'positive regulation of prostaglandin secretion', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'positive regulation of renal sodium excretion', 'positive regulation of sarcomere organization', 'positive regulation of signaling receptor activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'prostaglandin biosynthetic process', 'protein kinase A signaling', 'protein kinase C deactivation', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'regulation of glucose transmembrane transport', 'regulation of pH', 'regulation of sensory perception of pain', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'renal sodium ion absorption', 'respiratory gaseous exchange by respiratory system', 'response to activity', 'response to amino acid', 'response to amphetamine', 'response to dexamethasone', 'response to leptin', 'response to lipopolysaccharide', 'response to muscle stretch', 'response to nicotine', 'response to ozone', 'response to prostaglandin F', 'response to salt', 'response to testosterone', 'rhythmic excitation', 'semaphorin-plexin signaling pathway involved in axon guidance', 'sensory perception of pain', 'superoxide anion generation', 'sympathetic neuron axon guidance', 'thyroid gland development', 'transcription by RNA polymerase II', 'vasoconstriction', 'vein smooth muscle contraction']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'artery smooth muscle contraction', 'axon extension', 'axonogenesis involved in innervation', 'body fluid secretion', 'branching involved in blood vessel morphogenesis', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cardiac neural crest cell migration involved in outflow tract morphogenesis', 'cartilage development', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to calcium ion', 'cellular response to fatty acid', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to human chorionic gonadotropin stimulus', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to luteinizing hormone stimulus', 'cellular response to mineralocorticoid stimulus', 'cellular response to organic substance', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to xenobiotic stimulus', 'dorsal/ventral pattern formation', 'embryonic heart tube development', 'endothelin receptor signaling pathway', 'endothelin receptor signaling pathway involved in heart process', 'epithelial fluid transport', 'ERK1 and ERK2 cascade', 'G protein-coupled receptor signaling pathway', 'histamine secretion', 'I-kappaB kinase/NF-kappaB signaling', 'in utero embryonic development', 'inositol phosphate-mediated signaling', 'leukocyte activation', 'maternal process involved in parturition', 'meiotic cell cycle process involved in oocyte maturation', 'membrane depolarization', 'middle ear morphogenesis', 'mitochondrion organization', 'multicellular organism aging', 'negative regulation of blood coagulation', 'negative regulation of gene expression', 'negative regulation of hormone secretion', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein metabolic process', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'neural crest cell fate commitment', 'nitric oxide transport', 'noradrenergic neuron differentiation', 'peptide hormone secretion', 'pharyngeal arch artery morphogenesis', 'phosphatidylinositol 3-kinase signaling', 'phospholipase D-activating G protein-coupled receptor signaling pathway', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cation channel activity', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell size', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell migration', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of JUN kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of odontogenesis', 'positive regulation of prostaglandin secretion', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'positive regulation of renal sodium excretion', 'positive regulation of sarcomere organization', 'positive regulation of signaling receptor activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'prostaglandin biosynthetic process', 'protein kinase A signaling', 'protein kinase C deactivation', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'regulation of glucose transmembrane transport', 'regulation of pH', 'regulation of sensory perception of pain', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'renal sodium ion absorption', 'respiratory gaseous exchange by respiratory system', 'response to activity', 'response to amino acid', 'response to amphetamine', 'response to dexamethasone', 'response to leptin', 'response to lipopolysaccharide', 'response to muscle stretch', 'response to nicotine', 'response to ozone', 'response to prostaglandin F', 'response to salt', 'response to testosterone', 'rhythmic excitation', 'semaphorin-plexin signaling pathway involved in axon guidance', 'sensory perception of pain', 'superoxide anion generation', 'sympathetic neuron axon guidance', 'thyroid gland development', 'transcription by RNA polymerase II', 'vasoconstriction', 'vein smooth muscle contraction']
C-type lectin domain family 4 member A
222
C-type lectin domain family 4 member A
203
9.9
100
0.1
Q9UMR7Q9UMR7['adaptive immune response', 'antifungal innate immune response', 'antigen processing and presentation of exogenous peptide antigen via MHC class I', 'CD8-positive, alpha-beta T cell activation', 'cell adhesion', 'cell surface receptor signaling pathway', 'immune response', 'negative regulation of cytokine production', 'negative regulation of tumor necrosis factor production', 'plasmacytoid dendritic cell antigen processing and presentation']['adaptive immune response', 'antifungal innate immune response', 'antigen processing and presentation of exogenous peptide antigen via MHC class I', 'CD8-positive, alpha-beta T cell activation', 'cell adhesion', 'cell surface receptor signaling pathway', 'immune response', 'negative regulation of cytokine production', 'negative regulation of tumor necrosis factor production', 'plasmacytoid dendritic cell antigen processing and presentation']
Ferritin heavy chain
131
Ferritin heavy chain
131
9.9
73
0.14
P09528P09528['immune response', 'intracellular sequestering of iron ion', 'iron ion transport', 'negative regulation of cell population proliferation', 'negative regulation of fibroblast proliferation', 'negative regulation of necrotic cell death']['immune response', 'intracellular sequestering of iron ion', 'iron ion transport', 'negative regulation of cell population proliferation', 'negative regulation of fibroblast proliferation', 'negative regulation of necrotic cell death']
Norrin
69
Norrin
93
8.3
75
0.16
Q00604Q00604['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']
Speckle targeted PIP5K1A-regulated poly(A) polymerase
372
Speckle targeted PIP5K1A-regulated poly(A) polymerase
372
9.9
57
0.18
Q9H6E5Q9H6E5['mRNA polyadenylation', 'pre-mRNA cleavage required for polyadenylation', "RNA 3'-end processing", 'snRNA processing', "U6 snRNA 3'-end processing"]['mRNA polyadenylation', 'pre-mRNA cleavage required for polyadenylation', "RNA 3'-end processing", 'snRNA processing', "U6 snRNA 3'-end processing"]
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)
122
8.6
65
0.18
P10824B1H241['adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell cycle', 'cell division', 'cellular response to forskolin', 'G protein-coupled receptor signaling pathway', 'negative regulation of synaptic transmission', 'positive regulation of protein localization to cell cortex', 'regulation of cAMP-mediated signaling', 'regulation of mitotic spindle organization']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'basement membrane organization', 'cell migration involved in gastrulation', 'cell-cell adhesion involved in gastrulation', 'in utero embryonic development', 'vasculature development', 'visual learning']
Golgi reassembly-stacking protein 2
173
Golgin-45
392
8.3
70
0.17
Q99JX3Q8R2X8['cell differentiation', 'establishment of protein localization to plasma membrane', 'Golgi organization', 'organelle assembly', 'organelle organization', 'response to endoplasmic reticulum stress', 'spermatogenesis']['Golgi organization', 'Golgi to plasma membrane protein transport']
Proteasome subunit beta type-7
74
Proteasome subunit beta type-3
129
8.3
68
0.18
P70195Q9R1P1['proteasomal protein catabolic process']['proteasomal protein catabolic process', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein catabolic process']
Kallikrein-6
63
Amyloid-beta precursor protein
300
8.6
98
0.12
Q92876P05067['amyloid precursor protein metabolic process', 'central nervous system development', 'collagen catabolic process', 'hormone metabolic process', 'myelination', 'positive regulation of G protein-coupled receptor signaling pathway', 'protein autoprocessing', 'regulation of cell differentiation', 'regulation of neuron projection development', 'response to wounding', 'tissue regeneration']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Activin receptor type-1
395
Activin receptor type-1
395
8.6
46
0.25
Q04771Q04771['activin receptor signaling pathway', 'acute inflammatory response', 'atrial septum primum morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'BMP signaling pathway involved in heart development', 'branching involved in blood vessel morphogenesis', 'cardiac muscle cell fate commitment', 'cellular response to BMP stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to growth factor stimulus', 'determination of left/right symmetry', 'dorsal/ventral pattern formation', 'embryonic heart tube morphogenesis', 'endocardial cushion cell fate commitment', 'endocardial cushion fusion', 'endocardial cushion morphogenesis', 'gastrulation with mouth forming second', 'germ cell development', 'heart development', 'in utero embryonic development', 'mesoderm formation', 'mitral valve morphogenesis', 'negative regulation of activin receptor signaling pathway', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of signal transduction', 'neural crest cell migration', 'pathway-restricted SMAD protein phosphorylation', 'peptidyl-threonine phosphorylation', 'pharyngeal system development', 'positive regulation of bone mineralization', 'positive regulation of cell migration', 'positive regulation of determination of dorsal identity', 'positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'positive regulation of osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein phosphorylation', 'regulation of ossification', 'regulation of skeletal muscle tissue development', 'smooth muscle cell differentiation', 'transforming growth factor beta receptor signaling pathway', 'urogenital system development', 'ventricular septum morphogenesis']['activin receptor signaling pathway', 'acute inflammatory response', 'atrial septum primum morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'BMP signaling pathway involved in heart development', 'branching involved in blood vessel morphogenesis', 'cardiac muscle cell fate commitment', 'cellular response to BMP stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to growth factor stimulus', 'determination of left/right symmetry', 'dorsal/ventral pattern formation', 'embryonic heart tube morphogenesis', 'endocardial cushion cell fate commitment', 'endocardial cushion fusion', 'endocardial cushion morphogenesis', 'gastrulation with mouth forming second', 'germ cell development', 'heart development', 'in utero embryonic development', 'mesoderm formation', 'mitral valve morphogenesis', 'negative regulation of activin receptor signaling pathway', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of signal transduction', 'neural crest cell migration', 'pathway-restricted SMAD protein phosphorylation', 'peptidyl-threonine phosphorylation', 'pharyngeal system development', 'positive regulation of bone mineralization', 'positive regulation of cell migration', 'positive regulation of determination of dorsal identity', 'positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'positive regulation of osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein phosphorylation', 'regulation of ossification', 'regulation of skeletal muscle tissue development', 'smooth muscle cell differentiation', 'transforming growth factor beta receptor signaling pathway', 'urogenital system development', 'ventricular septum morphogenesis']
Pancreatic secretory granule membrane major glycoprotein GP2
146
Pancreatic secretory granule membrane major glycoprotein GP2
85
8.6
71
0.16
P55259P55259['antigen transcytosis by M cells in mucosal-associated lymphoid tissue', 'innate immune response', 'neutrophil migration']['antigen transcytosis by M cells in mucosal-associated lymphoid tissue', 'innate immune response', 'neutrophil migration']
Adrenodoxin, mitochondrial
106
Adrenodoxin, mitochondrial
106
8.4
55
0.22
P10109P10109['cellular response to cAMP', 'cellular response to forskolin', 'cholesterol metabolic process', 'electron transport chain', 'hormone biosynthetic process', 'P450-containing electron transport chain', 'positive regulation of oxidoreductase activity', 'steroid biosynthetic process']['cellular response to cAMP', 'cellular response to forskolin', 'cholesterol metabolic process', 'electron transport chain', 'hormone biosynthetic process', 'P450-containing electron transport chain', 'positive regulation of oxidoreductase activity', 'steroid biosynthetic process']
Resistin-like beta
91
Resistin-like beta
76
9.9
74
0.14
Q99P86Q99P86['response to bacterium']['response to bacterium']
Serine protease 1
64
Tissue factor pathway inhibitor 2
45
8.4
97
0.12
P00760P48307['digestion', 'proteolysis']['blood coagulation', 'cellular response to fluid shear stress']
Mucin-2
1090
Mucin-2
1088
8.4
82
0.15
Q02817Q02817['maintenance of gastrointestinal epithelium']['maintenance of gastrointestinal epithelium']
Defensin beta 4A
38
Defensin beta 4A
53
8.4
85
0.14
O15263O15263['antifungal innate immune response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell chemotaxis', 'chemotaxis', 'defense response to bacterium', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'G protein-coupled receptor signaling pathway', 'immune response', 'killing of cells of another organism', 'membrane disruption in another organism']['antifungal innate immune response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell chemotaxis', 'chemotaxis', 'defense response to bacterium', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'G protein-coupled receptor signaling pathway', 'immune response', 'killing of cells of another organism', 'membrane disruption in another organism']
Chymotrypsinogen A
58
Pancreatic trypsin inhibitor
49
8.4
98
0.12
P00766P00974['digestion', 'proteolysis']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
NAD-dependent protein deacetylase sirtuin-2
200
NAD-dependent protein deacetylase sirtuin-2
200
9.9
46
0.22
Q8IXJ6Q8IXJ6['autophagy', 'cell division', 'cellular lipid catabolic process', 'cellular response to caloric restriction', 'cellular response to epinephrine stimulus', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to hypoxia', 'cellular response to molecule of bacterial origin', 'cellular response to oxidative stress', 'hepatocyte growth factor receptor signaling pathway', 'heterochromatin assembly', 'histone deacetylation', 'histone H3 deacetylation', 'histone H4 deacetylation', 'innate immune response', 'meiotic cell cycle', 'mitotic nuclear membrane reassembly', 'myelination in peripheral nervous system', 'negative regulation of autophagy', 'negative regulation of cell population proliferation', 'negative regulation of defense response to bacterium', 'negative regulation of fat cell differentiation', 'negative regulation of NLRP3 inflammasome complex assembly', 'negative regulation of oligodendrocyte progenitor proliferation', 'negative regulation of peptidyl-threonine phosphorylation', 'negative regulation of protein catabolic process', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of striated muscle tissue development', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'negative regulation of transcription, DNA-templated', 'NLRP3 inflammasome complex assembly', 'peptidyl-lysine deacetylation', 'phosphatidylinositol 3-kinase signaling', 'positive regulation of attachment of spindle microtubules to kinetochore', 'positive regulation of cell division', 'positive regulation of DNA binding', 'positive regulation of execution phase of apoptosis', 'positive regulation of meiotic nuclear division', 'positive regulation of oocyte maturation', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia', 'positive regulation of transcription by RNA polymerase II', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ADP-ribosylation', 'protein deacetylation', 'protein kinase B signaling', 'rDNA heterochromatin assembly', 'regulation of cell cycle', 'regulation of exit from mitosis', 'regulation of myelination', 'regulation of phosphorylation', 'response to redox state', 'substantia nigra development', 'subtelomeric heterochromatin assembly', 'tubulin deacetylation']['autophagy', 'cell division', 'cellular lipid catabolic process', 'cellular response to caloric restriction', 'cellular response to epinephrine stimulus', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to hypoxia', 'cellular response to molecule of bacterial origin', 'cellular response to oxidative stress', 'hepatocyte growth factor receptor signaling pathway', 'heterochromatin assembly', 'histone deacetylation', 'histone H3 deacetylation', 'histone H4 deacetylation', 'innate immune response', 'meiotic cell cycle', 'mitotic nuclear membrane reassembly', 'myelination in peripheral nervous system', 'negative regulation of autophagy', 'negative regulation of cell population proliferation', 'negative regulation of defense response to bacterium', 'negative regulation of fat cell differentiation', 'negative regulation of NLRP3 inflammasome complex assembly', 'negative regulation of oligodendrocyte progenitor proliferation', 'negative regulation of peptidyl-threonine phosphorylation', 'negative regulation of protein catabolic process', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of striated muscle tissue development', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'negative regulation of transcription, DNA-templated', 'NLRP3 inflammasome complex assembly', 'peptidyl-lysine deacetylation', 'phosphatidylinositol 3-kinase signaling', 'positive regulation of attachment of spindle microtubules to kinetochore', 'positive regulation of cell division', 'positive regulation of DNA binding', 'positive regulation of execution phase of apoptosis', 'positive regulation of meiotic nuclear division', 'positive regulation of oocyte maturation', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia', 'positive regulation of transcription by RNA polymerase II', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ADP-ribosylation', 'protein deacetylation', 'protein kinase B signaling', 'rDNA heterochromatin assembly', 'regulation of cell cycle', 'regulation of exit from mitosis', 'regulation of myelination', 'regulation of phosphorylation', 'response to redox state', 'substantia nigra development', 'subtelomeric heterochromatin assembly', 'tubulin deacetylation']
Thiopurine S-methyltransferase
165
Thiopurine S-methyltransferase
165
8.4
66
0.18
O43213O43213['methylation', 'nucleobase-containing compound metabolic process', 'xenobiotic catabolic process', 'xenobiotic metabolic process']['methylation', 'nucleobase-containing compound metabolic process', 'xenobiotic catabolic process', 'xenobiotic metabolic process']
Gamma-crystallin S
23
Gamma-crystallin S
25
9.9
66
0.15
P22914P22914['lens development in camera-type eye', 'morphogenesis of an epithelium', 'visual perception']['lens development in camera-type eye', 'morphogenesis of an epithelium', 'visual perception']
Serine protease 1
64
Amyloid-beta precursor protein
300
8.4
97
0.12
P00760P05067['digestion', 'proteolysis']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Defensin-6
74
Defensin-6
74
8.4
62
0.19
Q01524Q01524['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism']
Protocadherin-15
277
Protocadherin-15
268
9.9
56
0.18
Q96QU1Q96QU1['cell adhesion', 'equilibrioception', 'homophilic cell adhesion via plasma membrane adhesion molecules', 'inner ear development', 'photoreceptor cell maintenance', 'sensory perception of light stimulus', 'sensory perception of sound']['cell adhesion', 'equilibrioception', 'homophilic cell adhesion via plasma membrane adhesion molecules', 'inner ear development', 'photoreceptor cell maintenance', 'sensory perception of light stimulus', 'sensory perception of sound']
Growth factor receptor-bound protein 7
527
Growth factor receptor-bound protein 7
527
8.4
75
0.16
Q14451Q14451['epidermal growth factor receptor signaling pathway', 'negative regulation of translation', 'positive regulation of cell migration', 'stress granule assembly']['epidermal growth factor receptor signaling pathway', 'negative regulation of translation', 'positive regulation of cell migration', 'stress granule assembly']
Anionic trypsin-2
64
Amyloid-beta precursor protein
300
8.3
94
0.13
P00763P05067['collagen catabolic process', 'digestion', 'proteolysis', 'response to nutrient']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Phospholipid-transporting ATPase IG
200
Phospholipid-transporting ATPase IG
168
9.4
50
0.21
Q8NB49Q8NB49['ion transmembrane transport', 'phospholipid translocation']['ion transmembrane transport', 'phospholipid translocation']
Acyl-protein thioesterase 1
211
Acyl-protein thioesterase 1
211
9.4
76
0.14
O75608O75608['fatty acid metabolic process', 'negative regulation of Golgi to plasma membrane protein transport', 'protein depalmitoylation']['fatty acid metabolic process', 'negative regulation of Golgi to plasma membrane protein transport', 'protein depalmitoylation']
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
266
Succinate dehydrogenase assembly factor 2, mitochondrial
83
9.7
88
0.12
P31040Q9NX18['mitochondrial electron transport, succinate to ubiquinone', 'nervous system development', 'proton motive force-driven mitochondrial ATP synthesis', 'respiratory electron transport chain', 'succinate metabolic process', 'tricarboxylic acid cycle']['mitochondrial electron transport, succinate to ubiquinone', 'mitochondrial respiratory chain complex II assembly', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of epithelial to mesenchymal transition', 'protein dephosphorylation', 'protein-FAD linkage', 'tricarboxylic acid cycle']
A disintegrin and metalloproteinase with thrombospondin motifs 5
371
A disintegrin and metalloproteinase with thrombospondin motifs 5
342
9.4
74
0.14
Q9UNA0Q9UNA0['defense response to bacterium', 'extracellular matrix disassembly', 'extracellular matrix organization', 'myoblast fusion', 'negative regulation of cold-induced thermogenesis', 'proteolysis', 'tooth eruption']['defense response to bacterium', 'extracellular matrix disassembly', 'extracellular matrix organization', 'myoblast fusion', 'negative regulation of cold-induced thermogenesis', 'proteolysis', 'tooth eruption']
Lamina-associated polypeptide 2, isoforms alpha/zeta
560
Lamina-associated polypeptide 2, isoforms alpha/zeta
560
9.4
51
0.21
Q61033Q61033['regulation of transcription, DNA-templated']['regulation of transcription, DNA-templated']
Thrombomodulin
466
Thrombomodulin
464
9.4
76
0.14
P07204P07204['blood coagulation', 'blood coagulation, common pathway', 'female pregnancy', 'negative regulation of blood coagulation', 'negative regulation of fibrinolysis', 'negative regulation of platelet activation', 'proteolysis', 'response to cAMP', 'response to lipopolysaccharide', 'response to X-ray', 'zymogen activation']['blood coagulation', 'blood coagulation, common pathway', 'female pregnancy', 'negative regulation of blood coagulation', 'negative regulation of fibrinolysis', 'negative regulation of platelet activation', 'proteolysis', 'response to cAMP', 'response to lipopolysaccharide', 'response to X-ray', 'zymogen activation']
Platelet-derived growth factor subunit B
124
Platelet-derived growth factor subunit B
97
9.4
64
0.17
P01127P01127['activation of protein kinase activity', 'activation of protein kinase B activity', 'cell chemotaxis', 'cellular response to growth factor stimulus', 'cellular response to mycophenolic acid', 'cellular response to platelet-derived growth factor stimulus', 'embryonic placenta development', 'heart development', 'interleukin-18-mediated signaling pathway', 'metanephric glomerular mesangial cell development', 'monocyte chemotaxis', 'negative regulation of gene expression', 'negative regulation of miRNA transcription', 'negative regulation of phosphatidylinositol biosynthetic process', 'negative regulation of platelet activation', 'negative regulation of protein binding', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular associated smooth muscle cell differentiation', 'paracrine signaling', 'peptidyl-serine phosphorylation', 'peptidyl-tyrosine phosphorylation', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of calcium ion import', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell-substrate adhesion', 'positive regulation of chemotaxis', 'positive regulation of cyclin-dependent protein serine/threonine kinase activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glomerular filtration', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of hyaluronan biosynthetic process', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of metanephric mesenchymal cell migration', 'positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway', 'positive regulation of miRNA transcription', 'positive regulation of mitotic nuclear division', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular associated smooth muscle cell dedifferentiation', 'positive regulation of vascular associated smooth muscle cell migration', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase C signaling', 'protein phosphorylation', 'reactive oxygen species metabolic process', 'response to wounding']['activation of protein kinase activity', 'activation of protein kinase B activity', 'cell chemotaxis', 'cellular response to growth factor stimulus', 'cellular response to mycophenolic acid', 'cellular response to platelet-derived growth factor stimulus', 'embryonic placenta development', 'heart development', 'interleukin-18-mediated signaling pathway', 'metanephric glomerular mesangial cell development', 'monocyte chemotaxis', 'negative regulation of gene expression', 'negative regulation of miRNA transcription', 'negative regulation of phosphatidylinositol biosynthetic process', 'negative regulation of platelet activation', 'negative regulation of protein binding', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular associated smooth muscle cell differentiation', 'paracrine signaling', 'peptidyl-serine phosphorylation', 'peptidyl-tyrosine phosphorylation', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of calcium ion import', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell-substrate adhesion', 'positive regulation of chemotaxis', 'positive regulation of cyclin-dependent protein serine/threonine kinase activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glomerular filtration', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of hyaluronan biosynthetic process', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of metanephric mesenchymal cell migration', 'positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway', 'positive regulation of miRNA transcription', 'positive regulation of mitotic nuclear division', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular associated smooth muscle cell dedifferentiation', 'positive regulation of vascular associated smooth muscle cell migration', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase C signaling', 'protein phosphorylation', 'reactive oxygen species metabolic process', 'response to wounding']
Zinc finger and BTB domain-containing protein 17
26
Zinc finger and BTB domain-containing protein 17
26
9.7
71
0.15
Q13105Q13105['ectoderm development', 'G1 to G0 transition', 'gastrulation with mouth forming second', 'negative regulation of cell cycle', 'negative regulation of cell population proliferation', 'positive regulation of transcription by RNA polymerase II', 'regulation of transcription by RNA polymerase II']['ectoderm development', 'G1 to G0 transition', 'gastrulation with mouth forming second', 'negative regulation of cell cycle', 'negative regulation of cell population proliferation', 'positive regulation of transcription by RNA polymerase II', 'regulation of transcription by RNA polymerase II']
Threonine aspartase 1
163
Threonine aspartase 1
271
9.3
97
0.11
Q9H6P5Q9H6P5['positive regulation of transcription, DNA-templated', 'protein maturation', 'proteolysis']['positive regulation of transcription, DNA-templated', 'protein maturation', 'proteolysis']
Thrombomodulin
451
Thrombomodulin
466
9.7
81
0.13
P07204P07204['blood coagulation', 'blood coagulation, common pathway', 'female pregnancy', 'negative regulation of blood coagulation', 'negative regulation of fibrinolysis', 'negative regulation of platelet activation', 'proteolysis', 'response to cAMP', 'response to lipopolysaccharide', 'response to X-ray', 'zymogen activation']['blood coagulation', 'blood coagulation, common pathway', 'female pregnancy', 'negative regulation of blood coagulation', 'negative regulation of fibrinolysis', 'negative regulation of platelet activation', 'proteolysis', 'response to cAMP', 'response to lipopolysaccharide', 'response to X-ray', 'zymogen activation']
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
358
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
358
9.3
50
0.21
Q8R5A3Q8R5A3['positive regulation of cell adhesion', 'signal transduction', 'T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell']['positive regulation of cell adhesion', 'signal transduction', 'T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell']
Nucleotide triphosphate diphosphatase NUDT15
23
Nucleotide triphosphate diphosphatase NUDT15
59
9.3
76
0.14
Q9NV35Q9NV35['dGTP catabolic process', 'DNA protection', 'mitotic cell cycle', 'nucleobase-containing small molecule metabolic process', 'nucleoside phosphate catabolic process', 'purine nucleotide catabolic process', 'regulation of proteasomal protein catabolic process', 'response to reactive oxygen species', 'xenobiotic catabolic process']['dGTP catabolic process', 'DNA protection', 'mitotic cell cycle', 'nucleobase-containing small molecule metabolic process', 'nucleoside phosphate catabolic process', 'purine nucleotide catabolic process', 'regulation of proteasomal protein catabolic process', 'response to reactive oxygen species', 'xenobiotic catabolic process']
Endothelin receptor type B
358
Endothelin-3
107
9.4
78
0.14
P24530P14138['aging', 'aldosterone metabolic process', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cell surface receptor signaling pathway', 'cellular response to lipopolysaccharide', 'cGMP-mediated signaling', 'developmental pigmentation', 'endothelin receptor signaling pathway', 'enteric nervous system development', 'enteric smooth muscle cell differentiation', 'epithelial fluid transport', 'establishment of endothelial barrier', 'gene expression', 'heparin metabolic process', 'I-kappaB kinase/NF-kappaB signaling', 'macrophage chemotaxis', 'melanocyte differentiation', 'negative regulation of adenylate cyclase activity', 'negative regulation of apoptotic process', 'negative regulation of neuron maturation', 'negative regulation of protein metabolic process', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'neural crest cell migration', 'neuroblast migration', 'peripheral nervous system development', 'pharynx development', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'podocyte differentiation', 'positive regulation of cell population proliferation', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of penile erection', 'positive regulation of protein phosphorylation', 'positive regulation of renal sodium excretion', 'positive regulation of urine volume', 'posterior midgut development', 'protein transmembrane transport', 'regulation of epithelial cell proliferation', 'regulation of fever generation', 'regulation of heart rate', 'regulation of pH', 'regulation of sensory perception of pain', 'renal albumin absorption', 'renal sodium excretion', 'renal sodium ion absorption', 'renin secretion into blood stream', 'response to endothelin', 'response to organic cyclic compound', 'response to pain', 'response to sodium phosphate', 'sensory perception of pain', 'vasoconstriction', 'vasodilation', 'vein smooth muscle contraction']['axon extension', 'axon guidance', 'blood circulation', 'cell population proliferation', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular magnesium ion homeostasis', 'establishment of localization in cell', 'inositol phosphate-mediated signaling', 'melanocyte differentiation', 'neural crest cell migration', 'neutrophil chemotaxis', 'peptide hormone secretion', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of leukocyte chemotaxis', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of potassium ion transmembrane transport', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'potassium ion transmembrane transport', 'regulation of developmental pigmentation', 'regulation of gene expression', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'signal transduction', 'vasoconstriction', 'vein smooth muscle contraction']
Glutamate receptor ionotropic, delta-2
83
Glutamate receptor ionotropic, delta-2
83
9.4
81
0.13
Q63226Q63226['cerebellar granule cell differentiation', 'excitatory postsynaptic potential', 'excitatory synapse assembly', 'heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules', 'modulation of chemical synaptic transmission', 'positive regulation of long-term synaptic depression', 'positive regulation of synapse assembly', 'prepulse inhibition', 'protein localization', 'regulation of neuron apoptotic process', 'regulation of neuron projection development', 'regulation of postsynaptic density assembly', 'regulation of presynapse assembly', 'synaptic transmission, glutamatergic']['cerebellar granule cell differentiation', 'excitatory postsynaptic potential', 'excitatory synapse assembly', 'heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules', 'modulation of chemical synaptic transmission', 'positive regulation of long-term synaptic depression', 'positive regulation of synapse assembly', 'prepulse inhibition', 'protein localization', 'regulation of neuron apoptotic process', 'regulation of neuron projection development', 'regulation of postsynaptic density assembly', 'regulation of presynapse assembly', 'synaptic transmission, glutamatergic']
Kallikrein-6
47
Amyloid-beta precursor protein
300
9.4
101
0.11
Q92876P05067['amyloid precursor protein metabolic process', 'central nervous system development', 'collagen catabolic process', 'hormone metabolic process', 'myelination', 'positive regulation of G protein-coupled receptor signaling pathway', 'protein autoprocessing', 'regulation of cell differentiation', 'regulation of neuron projection development', 'response to wounding', 'tissue regeneration']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Suppressor of tumorigenicity 14 protein
657
Pancreatic trypsin inhibitor
73
9.4
92
0.12
Q9Y5Y6P00974['epithelial cell morphogenesis involved in placental branching', 'keratinocyte differentiation', 'neural tube closure', 'protein catabolic process', 'proteolysis']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Glycoprotein hormones alpha chain
111
Follitropin subunit beta
112
9.3
80
0.13
P01215P01225['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Progesterone receptor
603
Progesterone receptor
603
9.3
62
0.17
P06401P06401['cell-cell signaling', 'glandular epithelial cell maturation', 'intracellular steroid hormone receptor signaling pathway', 'lung alveolus development', 'negative regulation of gene expression', 'ovulation from ovarian follicle', 'paracrine signaling', 'positive regulation of gene expression', 'positive regulation of transcription by RNA polymerase II', 'progesterone receptor signaling pathway', 'regulation of epithelial cell proliferation', 'regulation of transcription by RNA polymerase II', 'signal transduction', 'tertiary branching involved in mammary gland duct morphogenesis']['cell-cell signaling', 'glandular epithelial cell maturation', 'intracellular steroid hormone receptor signaling pathway', 'lung alveolus development', 'negative regulation of gene expression', 'ovulation from ovarian follicle', 'paracrine signaling', 'positive regulation of gene expression', 'positive regulation of transcription by RNA polymerase II', 'progesterone receptor signaling pathway', 'regulation of epithelial cell proliferation', 'regulation of transcription by RNA polymerase II', 'signal transduction', 'tertiary branching involved in mammary gland duct morphogenesis']
Mothers against decapentaplegic homolog 2
349
Zinc finger FYVE domain-containing protein 9
783
9.3
75
0.14
Q15796O95405['activin receptor signaling pathway', 'adrenal gland development', 'anatomical structure morphogenesis', 'anterior/posterior pattern specification', 'BMP signaling pathway', 'cell differentiation', 'cell fate commitment', 'common-partner SMAD protein phosphorylation', 'embryonic cranial skeleton morphogenesis', 'embryonic foregut morphogenesis', 'endoderm formation', 'gastrulation', 'in utero embryonic development', 'insulin secretion', 'intracellular signal transduction', 'lung development', 'mesoderm formation', 'negative regulation of cell population proliferation', 'negative regulation of transcription, DNA-templated', 'nodal signaling pathway', 'organ growth', 'pancreas development', 'paraxial mesoderm morphogenesis', 'pericardium development', 'positive regulation of BMP signaling pathway', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of gene expression', 'positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'post-embryonic development', 'primary miRNA processing', 'regulation of binding', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to glucose', 'secondary palate development', 'signal transduction involved in regulation of gene expression', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transcription, DNA-templated', 'transforming growth factor beta receptor signaling pathway', 'ureteric bud development', 'wound healing', 'zygotic specification of dorsal/ventral axis']['endocytosis', 'endosomal transport', 'transforming growth factor beta receptor signaling pathway']
Serine/threonine-protein kinase/endoribonuclease IRE1
630
Serine/threonine-protein kinase/endoribonuclease IRE1
630
9.3
75
0.14
O75460O75460['cellular response to glucose stimulus', 'cellular response to hydrogen peroxide', 'cellular response to unfolded protein', 'cellular response to vascular endothelial growth factor stimulus', 'endothelial cell proliferation', 'insulin metabolic process', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'IRE1-mediated unfolded protein response', 'mRNA catabolic process', 'mRNA cleavage', 'mRNA cleavage involved in mRNA processing', 'mRNA splicing, via endonucleolytic cleavage and ligation', 'peptidyl-serine autophosphorylation', 'peptidyl-serine trans-autophosphorylation', 'positive regulation of endoplasmic reticulum unfolded protein response', 'positive regulation of JUN kinase activity', 'positive regulation of RNA splicing', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of macroautophagy', 'response to endoplasmic reticulum stress']['cellular response to glucose stimulus', 'cellular response to hydrogen peroxide', 'cellular response to unfolded protein', 'cellular response to vascular endothelial growth factor stimulus', 'endothelial cell proliferation', 'insulin metabolic process', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'IRE1-mediated unfolded protein response', 'mRNA catabolic process', 'mRNA cleavage', 'mRNA cleavage involved in mRNA processing', 'mRNA splicing, via endonucleolytic cleavage and ligation', 'peptidyl-serine autophosphorylation', 'peptidyl-serine trans-autophosphorylation', 'positive regulation of endoplasmic reticulum unfolded protein response', 'positive regulation of JUN kinase activity', 'positive regulation of RNA splicing', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of macroautophagy', 'response to endoplasmic reticulum stress']
Poly [ADP-ribose] polymerase tankyrase-1
1242
Poly [ADP-ribose] polymerase tankyrase-1
1242
9.3
63
0.17
O95271O95271['cell division', 'mitotic spindle organization', 'mRNA transport', 'negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric', 'negative regulation of telomere maintenance via telomere lengthening', 'negative regulation of telomeric DNA binding', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of telomerase activity', 'positive regulation of telomere capping', 'positive regulation of telomere maintenance via telomerase', 'positive regulation of transcription by RNA polymerase II', 'protein ADP-ribosylation', 'protein auto-ADP-ribosylation', 'protein localization to chromosome, telomeric region', 'protein poly-ADP-ribosylation', 'protein polyubiquitination', 'protein transport', 'regulation of telomere maintenance via telomerase', 'spindle assembly', 'Wnt signaling pathway']['cell division', 'mitotic spindle organization', 'mRNA transport', 'negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric', 'negative regulation of telomere maintenance via telomere lengthening', 'negative regulation of telomeric DNA binding', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of telomerase activity', 'positive regulation of telomere capping', 'positive regulation of telomere maintenance via telomerase', 'positive regulation of transcription by RNA polymerase II', 'protein ADP-ribosylation', 'protein auto-ADP-ribosylation', 'protein localization to chromosome, telomeric region', 'protein poly-ADP-ribosylation', 'protein polyubiquitination', 'protein transport', 'regulation of telomere maintenance via telomerase', 'spindle assembly', 'Wnt signaling pathway']
Mineralocorticoid receptor
639
Mineralocorticoid receptor
655
9.7
71
0.15
P08235P08235['intracellular steroid hormone receptor signaling pathway', 'positive regulation of NIK/NF-kappaB signaling', 'regulation of transcription by RNA polymerase II', 'signal transduction']['intracellular steroid hormone receptor signaling pathway', 'positive regulation of NIK/NF-kappaB signaling', 'regulation of transcription by RNA polymerase II', 'signal transduction']
Frizzled-8
107
Frizzled-8
107
9.7
74
0.14
Q61091Q61091['angiogenesis', 'canonical Wnt signaling pathway', 'positive regulation of JUN kinase activity', 'positive regulation of protein phosphorylation', 'T cell differentiation in thymus', 'Wnt signaling pathway']['angiogenesis', 'canonical Wnt signaling pathway', 'positive regulation of JUN kinase activity', 'positive regulation of protein phosphorylation', 'T cell differentiation in thymus', 'Wnt signaling pathway']
Ceramide transfer protein
65
Ceramide transfer protein
27
9.4
63
0.17
Q9Y5P4Q9Y5P4['cell morphogenesis', 'cell population proliferation', 'ceramide metabolic process', 'ceramide transport', 'endoplasmic reticulum organization', 'ER to Golgi ceramide transport', 'heart morphogenesis', 'immune response', 'in utero embryonic development', 'intermembrane lipid transfer', 'intermembrane sphingolipid transfer', 'lipid homeostasis', 'mitochondrion morphogenesis', 'muscle contraction', 'response to endoplasmic reticulum stress', 'signal transduction']['cell morphogenesis', 'cell population proliferation', 'ceramide metabolic process', 'ceramide transport', 'endoplasmic reticulum organization', 'ER to Golgi ceramide transport', 'heart morphogenesis', 'immune response', 'in utero embryonic development', 'intermembrane lipid transfer', 'intermembrane sphingolipid transfer', 'lipid homeostasis', 'mitochondrion morphogenesis', 'muscle contraction', 'response to endoplasmic reticulum stress', 'signal transduction']
cGMP-dependent protein kinase 1
175
cGMP-dependent protein kinase 1
158
9.4
45
0.24
Q6P5T7Q6P5T7['actin cytoskeleton organization', 'cGMP-mediated signaling', 'dendrite development', 'forebrain development', 'negative regulation of platelet aggregation', 'negative regulation of vascular associated smooth muscle cell migration', 'negative regulation of vascular associated smooth muscle cell proliferation', 'neuron migration', 'protein phosphorylation', 'regulation of GTPase activity', 'relaxation of vascular associated smooth muscle', 'signal transduction']['actin cytoskeleton organization', 'cGMP-mediated signaling', 'dendrite development', 'forebrain development', 'negative regulation of platelet aggregation', 'negative regulation of vascular associated smooth muscle cell migration', 'negative regulation of vascular associated smooth muscle cell proliferation', 'neuron migration', 'protein phosphorylation', 'regulation of GTPase activity', 'relaxation of vascular associated smooth muscle', 'signal transduction']
DCC-interacting protein 13-alpha
570
DCC-interacting protein 13-alpha
570
9.3
57
0.19
Q9UKG1Q9UKG1['adiponectin-activated signaling pathway', 'cell cycle', 'cellular response to hepatocyte growth factor stimulus', 'insulin receptor signaling pathway', 'negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of glucose import', 'positive regulation of macropinocytosis', 'positive regulation of melanin biosynthetic process', 'protein import into nucleus', 'regulation of fibroblast migration', 'regulation of G1/S transition of mitotic cell cycle', 'regulation of glucose import', 'regulation of innate immune response', 'regulation of protein localization to plasma membrane', 'regulation of toll-like receptor 4 signaling pathway', 'signal transduction', 'signaling', 'transforming growth factor beta receptor signaling pathway']['adiponectin-activated signaling pathway', 'cell cycle', 'cellular response to hepatocyte growth factor stimulus', 'insulin receptor signaling pathway', 'negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of glucose import', 'positive regulation of macropinocytosis', 'positive regulation of melanin biosynthetic process', 'protein import into nucleus', 'regulation of fibroblast migration', 'regulation of G1/S transition of mitotic cell cycle', 'regulation of glucose import', 'regulation of innate immune response', 'regulation of protein localization to plasma membrane', 'regulation of toll-like receptor 4 signaling pathway', 'signal transduction', 'signaling', 'transforming growth factor beta receptor signaling pathway']
Bone morphogenetic protein 3
471
Bone morphogenetic protein 3
436
9.4
89
0.12
P12645P12645['cartilage development', 'cell-cell signaling', 'osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'skeletal system development', 'SMAD protein signal transduction']['cartilage development', 'cell-cell signaling', 'osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'skeletal system development', 'SMAD protein signal transduction']
Transforming growth factor beta-2 proprotein
411
Transforming growth factor beta-2 proprotein
379
9.4
86
0.12
P61812P61812['activation of protein kinase activity', 'ascending aorta morphogenesis', 'atrial septum morphogenesis', 'atrial septum primum morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'cardiac epithelial to mesenchymal transition', 'cardiac muscle cell proliferation', 'cardiac right ventricle morphogenesis', 'cardioblast differentiation', 'cell death', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'collagen fibril organization', 'cranial skeletal system development', 'dopamine biosynthetic process', 'embryo development ending in birth or egg hatching', 'embryonic digestive tract development', 'embryonic limb morphogenesis', 'endocardial cushion fusion', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'extrinsic apoptotic signaling pathway', 'eye development', 'generation of neurons', 'glial cell migration', 'hair follicle development', 'hair follicle morphogenesis', 'heart development', 'heart morphogenesis', 'heart valve morphogenesis', 'hemopoiesis', 'inner ear development', 'kidney development', 'male gonad development', 'membranous septum morphogenesis', 'negative regulation of alkaline phosphatase activity', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'negative regulation of gene expression', 'negative regulation of macrophage cytokine production', 'negative regulation of Ras protein signal transduction', 'neural retina development', 'neural tube closure', 'neuron development', 'neutrophil chemotaxis', 'odontogenesis', 'outflow tract septum morphogenesis', 'pathway-restricted SMAD protein phosphorylation', 'pharyngeal arch artery morphogenesis', 'positive regulation of cardioblast differentiation', 'positive regulation of cell adhesion mediated by integrin', 'positive regulation of cell cycle', 'positive regulation of cell division', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'positive regulation of heart contraction', 'positive regulation of immune response', 'positive regulation of integrin biosynthetic process', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of Notch signaling pathway', 'positive regulation of ossification', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of stress-activated MAPK cascade', 'positive regulation of timing of catagen', 'protein phosphorylation', 'pulmonary valve morphogenesis', 'regulation of apoptotic process involved in outflow tract morphogenesis', 'regulation of cell population proliferation', 'regulation of timing of catagen', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to progesterone', 'response to wounding', 'response to xenobiotic stimulus', 'salivary gland morphogenesis', 'secondary palate development', 'skeletal system development', 'SMAD protein signal transduction', 'somatic stem cell division', 'substantia propria of cornea development', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'uterus development', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis', 'wound healing']['activation of protein kinase activity', 'ascending aorta morphogenesis', 'atrial septum morphogenesis', 'atrial septum primum morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'cardiac epithelial to mesenchymal transition', 'cardiac muscle cell proliferation', 'cardiac right ventricle morphogenesis', 'cardioblast differentiation', 'cell death', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'collagen fibril organization', 'cranial skeletal system development', 'dopamine biosynthetic process', 'embryo development ending in birth or egg hatching', 'embryonic digestive tract development', 'embryonic limb morphogenesis', 'endocardial cushion fusion', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'extrinsic apoptotic signaling pathway', 'eye development', 'generation of neurons', 'glial cell migration', 'hair follicle development', 'hair follicle morphogenesis', 'heart development', 'heart morphogenesis', 'heart valve morphogenesis', 'hemopoiesis', 'inner ear development', 'kidney development', 'male gonad development', 'membranous septum morphogenesis', 'negative regulation of alkaline phosphatase activity', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'negative regulation of gene expression', 'negative regulation of macrophage cytokine production', 'negative regulation of Ras protein signal transduction', 'neural retina development', 'neural tube closure', 'neuron development', 'neutrophil chemotaxis', 'odontogenesis', 'outflow tract septum morphogenesis', 'pathway-restricted SMAD protein phosphorylation', 'pharyngeal arch artery morphogenesis', 'positive regulation of cardioblast differentiation', 'positive regulation of cell adhesion mediated by integrin', 'positive regulation of cell cycle', 'positive regulation of cell division', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'positive regulation of heart contraction', 'positive regulation of immune response', 'positive regulation of integrin biosynthetic process', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of Notch signaling pathway', 'positive regulation of ossification', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of stress-activated MAPK cascade', 'positive regulation of timing of catagen', 'protein phosphorylation', 'pulmonary valve morphogenesis', 'regulation of apoptotic process involved in outflow tract morphogenesis', 'regulation of cell population proliferation', 'regulation of timing of catagen', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to progesterone', 'response to wounding', 'response to xenobiotic stimulus', 'salivary gland morphogenesis', 'secondary palate development', 'skeletal system development', 'SMAD protein signal transduction', 'somatic stem cell division', 'substantia propria of cornea development', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'uterus development', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis', 'wound healing']
Sequestosome-1
154
Sequestosome-1
131
9.4
56
0.19
Q13501Q13501['aggrephagy', 'apoptotic process', 'autophagy', 'autophagy of mitochondrion', 'brown fat cell proliferation', 'cell differentiation', 'endosomal transport', 'endosome organization', 'energy homeostasis', 'immune system process', 'intracellular signal transduction', 'macroautophagy', 'mitophagy', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of apoptotic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'protein import into nucleus', 'protein localization', 'protein localization to perinuclear region of cytoplasm', 'protein phosphorylation', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of mitochondrion organization', 'regulation of protein complex stability', 'regulation of Ras protein signal transduction', 'response to ischemia', 'response to mitochondrial depolarisation', 'selective autophagy', 'temperature homeostasis', 'transcription by RNA polymerase II', 'ubiquitin-dependent protein catabolic process']['aggrephagy', 'apoptotic process', 'autophagy', 'autophagy of mitochondrion', 'brown fat cell proliferation', 'cell differentiation', 'endosomal transport', 'endosome organization', 'energy homeostasis', 'immune system process', 'intracellular signal transduction', 'macroautophagy', 'mitophagy', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of apoptotic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'protein import into nucleus', 'protein localization', 'protein localization to perinuclear region of cytoplasm', 'protein phosphorylation', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of mitochondrion organization', 'regulation of protein complex stability', 'regulation of Ras protein signal transduction', 'response to ischemia', 'response to mitochondrial depolarisation', 'selective autophagy', 'temperature homeostasis', 'transcription by RNA polymerase II', 'ubiquitin-dependent protein catabolic process']
Resistin-like beta
102
Resistin-like beta
49
9.3
73
0.15
Q99P86Q99P86['response to bacterium']['response to bacterium']
Progesterone receptor
622
Progesterone receptor
609
9.2
71
0.15
P06401P06401['cell-cell signaling', 'glandular epithelial cell maturation', 'intracellular steroid hormone receptor signaling pathway', 'lung alveolus development', 'negative regulation of gene expression', 'ovulation from ovarian follicle', 'paracrine signaling', 'positive regulation of gene expression', 'positive regulation of transcription by RNA polymerase II', 'progesterone receptor signaling pathway', 'regulation of epithelial cell proliferation', 'regulation of transcription by RNA polymerase II', 'signal transduction', 'tertiary branching involved in mammary gland duct morphogenesis']['cell-cell signaling', 'glandular epithelial cell maturation', 'intracellular steroid hormone receptor signaling pathway', 'lung alveolus development', 'negative regulation of gene expression', 'ovulation from ovarian follicle', 'paracrine signaling', 'positive regulation of gene expression', 'positive regulation of transcription by RNA polymerase II', 'progesterone receptor signaling pathway', 'regulation of epithelial cell proliferation', 'regulation of transcription by RNA polymerase II', 'signal transduction', 'tertiary branching involved in mammary gland duct morphogenesis']
Leucine carboxyl methyltransferase 1
30
Leucine carboxyl methyltransferase 1
136
9.7
62
0.17
Q9UIC8Q9UIC8['C-terminal protein methylation', 'G2/M transition of mitotic cell cycle', 'negative regulation of protein-containing complex assembly', 'protein methylation', 'protein modification process', 'regulation of apoptotic process', 'regulation of glucose metabolic process', 'regulation of mitotic cell cycle spindle assembly checkpoint']['C-terminal protein methylation', 'G2/M transition of mitotic cell cycle', 'negative regulation of protein-containing complex assembly', 'protein methylation', 'protein modification process', 'regulation of apoptotic process', 'regulation of glucose metabolic process', 'regulation of mitotic cell cycle spindle assembly checkpoint']
Serine protease 1
48
Tissue factor pathway inhibitor 2
45
9.3
99
0.11
P00760P48307['digestion', 'proteolysis']['blood coagulation', 'cellular response to fluid shear stress']
Gremlin-1
122
Gremlin-1
122
9.7
84
0.12
O60565O60565['animal organ morphogenesis', 'apoptotic process', 'cardiac muscle cell differentiation', 'cardiac muscle cell myoblast differentiation', 'cell migration involved in sprouting angiogenesis', 'cell morphogenesis', 'cell-cell signaling', 'collagen fibril organization', 'determination of dorsal identity', 'embryonic limb morphogenesis', 'limb development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'negative regulation of apoptotic process', 'negative regulation of BMP signaling pathway', 'negative regulation of bone mineralization', 'negative regulation of bone mineralization involved in bone maturation', 'negative regulation of bone remodeling', 'negative regulation of bone trabecula formation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell growth', 'negative regulation of chondrocyte differentiation', 'negative regulation of monocyte chemotaxis', 'negative regulation of osteoblast differentiation', 'negative regulation of osteoblast proliferation', 'negative regulation of osteoclast proliferation', 'negative regulation of pathway-restricted SMAD protein phosphorylation', 'negative regulation of transcription, DNA-templated', 'positive regulation of angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell population proliferation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of receptor internalization', 'positive regulation of signaling receptor activity', 'positive regulation of telomerase activity', 'positive regulation of transcription by RNA polymerase II', 'proximal/distal pattern formation', 'regulation of epithelial to mesenchymal transition', 'regulation of focal adhesion assembly', 'sequestering of BMP from receptor via BMP binding', 'signal transduction', 'ureteric bud formation']['animal organ morphogenesis', 'apoptotic process', 'cardiac muscle cell differentiation', 'cardiac muscle cell myoblast differentiation', 'cell migration involved in sprouting angiogenesis', 'cell morphogenesis', 'cell-cell signaling', 'collagen fibril organization', 'determination of dorsal identity', 'embryonic limb morphogenesis', 'limb development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'negative regulation of apoptotic process', 'negative regulation of BMP signaling pathway', 'negative regulation of bone mineralization', 'negative regulation of bone mineralization involved in bone maturation', 'negative regulation of bone remodeling', 'negative regulation of bone trabecula formation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell growth', 'negative regulation of chondrocyte differentiation', 'negative regulation of monocyte chemotaxis', 'negative regulation of osteoblast differentiation', 'negative regulation of osteoblast proliferation', 'negative regulation of osteoclast proliferation', 'negative regulation of pathway-restricted SMAD protein phosphorylation', 'negative regulation of transcription, DNA-templated', 'positive regulation of angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell population proliferation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of receptor internalization', 'positive regulation of signaling receptor activity', 'positive regulation of telomerase activity', 'positive regulation of transcription by RNA polymerase II', 'proximal/distal pattern formation', 'regulation of epithelial to mesenchymal transition', 'regulation of focal adhesion assembly', 'sequestering of BMP from receptor via BMP binding', 'signal transduction', 'ureteric bud formation']
E3 ubiquitin-protein ligase TRIM7
390
E3 ubiquitin-protein ligase TRIM7
455
9.3
81
0.13
Q9C029Q9C029['protein ubiquitination']['protein ubiquitination']
Voltage-gated hydrogen channel 1
245
Voltage-gated hydrogen channel 1
245
9.7
52
0.2
Q3U2S8Q3U2S8['cellular response to pH', 'cellular response to zinc ion', 'positive regulation of superoxide anion generation', 'proton transmembrane transport', 'regulation of intracellular pH', 'regulation of ion transmembrane transport', 'response to pH', 'response to zinc ion']['cellular response to pH', 'cellular response to zinc ion', 'positive regulation of superoxide anion generation', 'proton transmembrane transport', 'regulation of intracellular pH', 'regulation of ion transmembrane transport', 'response to pH', 'response to zinc ion']
Fibrinogen beta chain
110
Fibrinogen gamma chain
35
8.6
61
0.19
P02675P02679['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Alanine--glyoxylate aminotransferase
106
Alanine--glyoxylate aminotransferase
106
8.3
82
0.15
Q8R128Q8R128['glycine biosynthetic process, by transamination of glyoxylate', 'glyoxylate catabolic process', 'glyoxylate metabolic process', 'L-alanine catabolic process', 'L-cysteine catabolic process', 'L-serine metabolic process', 'Notch signaling pathway', 'oxalic acid secretion', 'pyruvate biosynthetic process', 'response to cAMP', 'response to glucocorticoid']['glycine biosynthetic process, by transamination of glyoxylate', 'glyoxylate catabolic process', 'glyoxylate metabolic process', 'L-alanine catabolic process', 'L-cysteine catabolic process', 'L-serine metabolic process', 'Notch signaling pathway', 'oxalic acid secretion', 'pyruvate biosynthetic process', 'response to cAMP', 'response to glucocorticoid']
Growth/differentiation factor 15
273
Growth/differentiation factor 15
274
8.6
83
0.14
Q99988Q99988['BMP signaling pathway', 'cell-cell signaling', 'glial cell-derived neurotrophic factor receptor signaling pathway', 'negative regulation of growth hormone receptor signaling pathway', 'negative regulation of multicellular organism growth', 'positive regulation of MAPK cascade', 'positive regulation of myoblast fusion', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein kinase B signaling', 'reduction of food intake in response to dietary excess', 'signal transduction', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['BMP signaling pathway', 'cell-cell signaling', 'glial cell-derived neurotrophic factor receptor signaling pathway', 'negative regulation of growth hormone receptor signaling pathway', 'negative regulation of multicellular organism growth', 'positive regulation of MAPK cascade', 'positive regulation of myoblast fusion', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein kinase B signaling', 'reduction of food intake in response to dietary excess', 'signal transduction', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
Ig gamma-2A chain C region, A allele
112
Ig gamma-2A chain C region, A allele
110
8.6
36
0.32
P01863P01863['B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'response to bacterium']['B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'response to bacterium']
Growth/differentiation factor 5
500
Growth/differentiation factor 5
465
9.9
85
0.12
P43026P43026['BMP signaling pathway', 'cell-cell signaling', 'chondroblast differentiation', 'chondrocyte differentiation', 'embryonic limb morphogenesis', 'forelimb morphogenesis', 'hindlimb morphogenesis', 'mesenchymal cell apoptotic process', 'negative regulation of chondrocyte differentiation', 'negative regulation of epithelial cell proliferation', 'negative regulation of mesenchymal cell apoptotic process', 'negative regulation of neuron apoptotic process', 'ossification involved in bone remodeling', 'positive regulation of BMP signaling pathway', 'positive regulation of chondrocyte differentiation', 'positive regulation of neuron differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'regulation of multicellular organism growth', 'regulation of SMAD protein signal transduction', 'response to mechanical stimulus', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['BMP signaling pathway', 'cell-cell signaling', 'chondroblast differentiation', 'chondrocyte differentiation', 'embryonic limb morphogenesis', 'forelimb morphogenesis', 'hindlimb morphogenesis', 'mesenchymal cell apoptotic process', 'negative regulation of chondrocyte differentiation', 'negative regulation of epithelial cell proliferation', 'negative regulation of mesenchymal cell apoptotic process', 'negative regulation of neuron apoptotic process', 'ossification involved in bone remodeling', 'positive regulation of BMP signaling pathway', 'positive regulation of chondrocyte differentiation', 'positive regulation of neuron differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'regulation of multicellular organism growth', 'regulation of SMAD protein signal transduction', 'response to mechanical stimulus', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
Ubiquitin carboxyl-terminal hydrolase 25
551
Ubiquitin carboxyl-terminal hydrolase 25
551
8.6
65
0.18
Q9UHP3Q9UHP3['negative regulation of ERAD pathway', 'protein deubiquitination', 'protein K48-linked deubiquitination', 'protein K63-linked deubiquitination', 'protein modification process', 'proteolysis', 'ubiquitin-dependent protein catabolic process']['negative regulation of ERAD pathway', 'protein deubiquitination', 'protein K48-linked deubiquitination', 'protein K63-linked deubiquitination', 'protein modification process', 'proteolysis', 'ubiquitin-dependent protein catabolic process']
Chymotrypsinogen A
58
Amyloid-beta precursor protein
300
8.3
97
0.12
P00766P05067['digestion', 'proteolysis']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Serine/threonine-protein kinase MRCK beta
36
Serine/threonine-protein kinase MRCK beta
41
8.3
69
0.17
Q9Y5S2Q9Y5S2['actin cytoskeleton reorganization', 'actomyosin structure organization', 'cell migration', 'cytoskeleton organization', 'establishment or maintenance of cell polarity', 'peptidyl-threonine phosphorylation', 'protein phosphorylation', 'signal transduction']['actin cytoskeleton reorganization', 'actomyosin structure organization', 'cell migration', 'cytoskeleton organization', 'establishment or maintenance of cell polarity', 'peptidyl-threonine phosphorylation', 'protein phosphorylation', 'signal transduction']
Glutathione S-transferase Mu 1
87
Glutathione S-transferase Mu 1
78
9.9
77
0.13
P09488P09488['cellular detoxification of nitrogen compound', 'glutathione derivative biosynthetic process', 'glutathione metabolic process', 'hepoxilin biosynthetic process', 'nitrobenzene metabolic process', 'prostaglandin metabolic process', 'xenobiotic catabolic process']['cellular detoxification of nitrogen compound', 'glutathione derivative biosynthetic process', 'glutathione metabolic process', 'hepoxilin biosynthetic process', 'nitrobenzene metabolic process', 'prostaglandin metabolic process', 'xenobiotic catabolic process']
CDC42BPB protein
41
CDC42BPB protein
36
8.6
72
0.16
Q86XZ8Q86XZ8['actin cytoskeleton organization', 'cell migration', 'protein phosphorylation']['actin cytoskeleton organization', 'cell migration', 'protein phosphorylation']
Defensin alpha 5
82
Defensin alpha 5
82
8.6
68
0.17
Q01523Q01523['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']
Fibrinogen gamma chain
34
Fibrinogen gamma chain
45
8.6
76
0.15
P02679P02679['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
E3 ubiquitin-protein ligase TRIM7
378
E3 ubiquitin-protein ligase TRIM7
378
8.3
72
0.17
Q9C029Q9C029['protein ubiquitination']['protein ubiquitination']
Sequestosome-1
131
Sequestosome-1
131
8.3
56
0.22
Q13501Q13501['aggrephagy', 'apoptotic process', 'autophagy', 'autophagy of mitochondrion', 'brown fat cell proliferation', 'cell differentiation', 'endosomal transport', 'endosome organization', 'energy homeostasis', 'immune system process', 'intracellular signal transduction', 'macroautophagy', 'mitophagy', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of apoptotic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'protein import into nucleus', 'protein localization', 'protein localization to perinuclear region of cytoplasm', 'protein phosphorylation', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of mitochondrion organization', 'regulation of protein complex stability', 'regulation of Ras protein signal transduction', 'response to ischemia', 'response to mitochondrial depolarisation', 'selective autophagy', 'temperature homeostasis', 'transcription by RNA polymerase II', 'ubiquitin-dependent protein catabolic process']['aggrephagy', 'apoptotic process', 'autophagy', 'autophagy of mitochondrion', 'brown fat cell proliferation', 'cell differentiation', 'endosomal transport', 'endosome organization', 'energy homeostasis', 'immune system process', 'intracellular signal transduction', 'macroautophagy', 'mitophagy', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of apoptotic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'protein import into nucleus', 'protein localization', 'protein localization to perinuclear region of cytoplasm', 'protein phosphorylation', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of mitochondrion organization', 'regulation of protein complex stability', 'regulation of Ras protein signal transduction', 'response to ischemia', 'response to mitochondrial depolarisation', 'selective autophagy', 'temperature homeostasis', 'transcription by RNA polymerase II', 'ubiquitin-dependent protein catabolic process']
Growth/differentiation factor 8
339
Growth/differentiation factor 8
340
8.6
81
0.14
O14793O14793['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'muscle organ development', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'muscle organ development', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
MORC family CW-type zinc finger protein 3
416
MORC family CW-type zinc finger protein 3
416
9.9
66
0.15
Q14149Q14149['innate immune response', 'maintenance of protein location in nucleus', 'negative regulation of fibroblast proliferation', 'peptidyl-serine phosphorylation', 'positive regulation of cellular senescence', 'post-embryonic development', 'protein phosphorylation', 'protein stabilization']['innate immune response', 'maintenance of protein location in nucleus', 'negative regulation of fibroblast proliferation', 'peptidyl-serine phosphorylation', 'positive regulation of cellular senescence', 'post-embryonic development', 'protein phosphorylation', 'protein stabilization']
Peroxisomal multifunctional enzyme type 2
230
Peroxisomal multifunctional enzyme type 2
277
8.6
59
0.2
P97852P97852['aging', 'androgen metabolic process', 'cellular response to organic cyclic compound', 'cholesterol metabolic process', 'estrogen metabolic process', 'fatty acid beta-oxidation', 'medium-chain fatty-acyl-CoA metabolic process', 'response to organic cyclic compound', 'response to steroid hormone', 'response to xenobiotic stimulus', 'Sertoli cell development', 'very long-chain fatty acid metabolic process', 'very long-chain fatty-acyl-CoA metabolic process']['aging', 'androgen metabolic process', 'cellular response to organic cyclic compound', 'cholesterol metabolic process', 'estrogen metabolic process', 'fatty acid beta-oxidation', 'medium-chain fatty-acyl-CoA metabolic process', 'response to organic cyclic compound', 'response to steroid hormone', 'response to xenobiotic stimulus', 'Sertoli cell development', 'very long-chain fatty acid metabolic process', 'very long-chain fatty-acyl-CoA metabolic process']
Pulmonary surfactant-associated protein B
321
Pulmonary surfactant-associated protein B
321
8.3
76
0.16
P50405P50405['respiratory gaseous exchange by respiratory system', 'sphingolipid metabolic process']['respiratory gaseous exchange by respiratory system', 'sphingolipid metabolic process']
Glutamate receptor ionotropic, delta-2
83
Glutamate receptor ionotropic, delta-2
355
9.9
75
0.13
Q63226Q63226['cerebellar granule cell differentiation', 'excitatory postsynaptic potential', 'excitatory synapse assembly', 'heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules', 'modulation of chemical synaptic transmission', 'positive regulation of long-term synaptic depression', 'positive regulation of synapse assembly', 'prepulse inhibition', 'protein localization', 'regulation of neuron apoptotic process', 'regulation of neuron projection development', 'regulation of postsynaptic density assembly', 'regulation of presynapse assembly', 'synaptic transmission, glutamatergic']['cerebellar granule cell differentiation', 'excitatory postsynaptic potential', 'excitatory synapse assembly', 'heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules', 'modulation of chemical synaptic transmission', 'positive regulation of long-term synaptic depression', 'positive regulation of synapse assembly', 'prepulse inhibition', 'protein localization', 'regulation of neuron apoptotic process', 'regulation of neuron projection development', 'regulation of postsynaptic density assembly', 'regulation of presynapse assembly', 'synaptic transmission, glutamatergic']
Synembryn-A
122
Guanine nucleotide-binding protein G(t) subunit alpha-2
351
8.5
65
0.18
Q5E9J8P19087['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'basement membrane organization', 'cell migration involved in gastrulation', 'cell-cell adhesion involved in gastrulation', 'G protein-coupled receptor signaling pathway', 'in utero embryonic development', 'vasculature development', 'visual learning']['adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'detection of chemical stimulus involved in sensory perception of bitter taste', 'detection of light stimulus involved in visual perception', 'G protein-coupled receptor signaling pathway', 'phototransduction', 'positive regulation of cytosolic calcium ion concentration', 'response to light intensity', 'retinal cone cell development', 'visual perception']
Nuclear receptor ROR-gamma
455
Nuclear receptor ROR-gamma
455
8.5
67
0.17
P51449P51449['adipose tissue development', 'cellular response to sterol', 'circadian regulation of gene expression', 'lymph node development', 'negative regulation of thymocyte apoptotic process', 'negative regulation of transcription by RNA polymerase II', "Peyer's patch development", 'positive regulation of circadian rhythm', 'positive regulation of transcription, DNA-templated', 'regulation of fat cell differentiation', 'regulation of glucose metabolic process', 'regulation of steroid metabolic process', 'regulation of transcription by RNA polymerase II', 'T-helper 17 cell differentiation', 'T-helper cell differentiation', 'xenobiotic metabolic process']['adipose tissue development', 'cellular response to sterol', 'circadian regulation of gene expression', 'lymph node development', 'negative regulation of thymocyte apoptotic process', 'negative regulation of transcription by RNA polymerase II', "Peyer's patch development", 'positive regulation of circadian rhythm', 'positive regulation of transcription, DNA-templated', 'regulation of fat cell differentiation', 'regulation of glucose metabolic process', 'regulation of steroid metabolic process', 'regulation of transcription by RNA polymerase II', 'T-helper 17 cell differentiation', 'T-helper cell differentiation', 'xenobiotic metabolic process']
Cryptochrome-2
432
F-box/LRR-repeat protein 3
340
8.3
87
0.14
Q9R194Q9UKT7['circadian regulation of gene expression', 'circadian rhythm', 'entrainment of circadian clock by photoperiod', 'glucose homeostasis', 'lipid storage', 'negative regulation of circadian rhythm', 'negative regulation of glucocorticoid receptor signaling pathway', 'negative regulation of glucocorticoid secretion', 'negative regulation of phosphoprotein phosphatase activity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'protein import into nucleus', 'regulation of circadian rhythm', 'regulation of sodium-dependent phosphate transport', 'response to activity', 'response to insulin', 'response to light stimulus']['entrainment of circadian clock by photoperiod', 'G2/M transition of mitotic cell cycle', 'protein destabilization', 'protein ubiquitination', 'regulation of cell cycle', 'regulation of circadian rhythm', 'rhythmic process', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process']
Coagulation factor XI
432
Amyloid-beta precursor protein
300
8.6
99
0.12
P03951P05067['blood coagulation', 'blood coagulation, intrinsic pathway', 'plasminogen activation', 'positive regulation of fibrinolysis', 'proteolysis', 'zymogen activation']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Transforming growth factor beta-2 proprotein
379
Transforming growth factor beta-2 proprotein
350
8.3
65
0.18
P61812P61812['activation of protein kinase activity', 'ascending aorta morphogenesis', 'atrial septum morphogenesis', 'atrial septum primum morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'cardiac epithelial to mesenchymal transition', 'cardiac muscle cell proliferation', 'cardiac right ventricle morphogenesis', 'cardioblast differentiation', 'cell death', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'collagen fibril organization', 'cranial skeletal system development', 'dopamine biosynthetic process', 'embryo development ending in birth or egg hatching', 'embryonic digestive tract development', 'embryonic limb morphogenesis', 'endocardial cushion fusion', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'extrinsic apoptotic signaling pathway', 'eye development', 'generation of neurons', 'glial cell migration', 'hair follicle development', 'hair follicle morphogenesis', 'heart development', 'heart morphogenesis', 'heart valve morphogenesis', 'hemopoiesis', 'inner ear development', 'kidney development', 'male gonad development', 'membranous septum morphogenesis', 'negative regulation of alkaline phosphatase activity', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'negative regulation of gene expression', 'negative regulation of macrophage cytokine production', 'negative regulation of Ras protein signal transduction', 'neural retina development', 'neural tube closure', 'neuron development', 'neutrophil chemotaxis', 'odontogenesis', 'outflow tract septum morphogenesis', 'pathway-restricted SMAD protein phosphorylation', 'pharyngeal arch artery morphogenesis', 'positive regulation of cardioblast differentiation', 'positive regulation of cell adhesion mediated by integrin', 'positive regulation of cell cycle', 'positive regulation of cell division', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'positive regulation of heart contraction', 'positive regulation of immune response', 'positive regulation of integrin biosynthetic process', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of Notch signaling pathway', 'positive regulation of ossification', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of stress-activated MAPK cascade', 'positive regulation of timing of catagen', 'protein phosphorylation', 'pulmonary valve morphogenesis', 'regulation of apoptotic process involved in outflow tract morphogenesis', 'regulation of cell population proliferation', 'regulation of timing of catagen', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to progesterone', 'response to wounding', 'response to xenobiotic stimulus', 'salivary gland morphogenesis', 'secondary palate development', 'skeletal system development', 'SMAD protein signal transduction', 'somatic stem cell division', 'substantia propria of cornea development', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'uterus development', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis', 'wound healing']['activation of protein kinase activity', 'ascending aorta morphogenesis', 'atrial septum morphogenesis', 'atrial septum primum morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'cardiac epithelial to mesenchymal transition', 'cardiac muscle cell proliferation', 'cardiac right ventricle morphogenesis', 'cardioblast differentiation', 'cell death', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'collagen fibril organization', 'cranial skeletal system development', 'dopamine biosynthetic process', 'embryo development ending in birth or egg hatching', 'embryonic digestive tract development', 'embryonic limb morphogenesis', 'endocardial cushion fusion', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'extrinsic apoptotic signaling pathway', 'eye development', 'generation of neurons', 'glial cell migration', 'hair follicle development', 'hair follicle morphogenesis', 'heart development', 'heart morphogenesis', 'heart valve morphogenesis', 'hemopoiesis', 'inner ear development', 'kidney development', 'male gonad development', 'membranous septum morphogenesis', 'negative regulation of alkaline phosphatase activity', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'negative regulation of gene expression', 'negative regulation of macrophage cytokine production', 'negative regulation of Ras protein signal transduction', 'neural retina development', 'neural tube closure', 'neuron development', 'neutrophil chemotaxis', 'odontogenesis', 'outflow tract septum morphogenesis', 'pathway-restricted SMAD protein phosphorylation', 'pharyngeal arch artery morphogenesis', 'positive regulation of cardioblast differentiation', 'positive regulation of cell adhesion mediated by integrin', 'positive regulation of cell cycle', 'positive regulation of cell division', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'positive regulation of heart contraction', 'positive regulation of immune response', 'positive regulation of integrin biosynthetic process', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of Notch signaling pathway', 'positive regulation of ossification', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of stress-activated MAPK cascade', 'positive regulation of timing of catagen', 'protein phosphorylation', 'pulmonary valve morphogenesis', 'regulation of apoptotic process involved in outflow tract morphogenesis', 'regulation of cell population proliferation', 'regulation of timing of catagen', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to progesterone', 'response to wounding', 'response to xenobiotic stimulus', 'salivary gland morphogenesis', 'secondary palate development', 'skeletal system development', 'SMAD protein signal transduction', 'somatic stem cell division', 'substantia propria of cornea development', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'uterus development', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis', 'wound healing']
Proteasome subunit beta type-3
129
Proteasome subunit beta type-10
70
8.3
72
0.17
P49720P40306['proteasomal protein catabolic process', 'proteasome-mediated ubiquitin-dependent protein catabolic process']['cell morphogenesis', 'humoral immune response', 'proteasomal protein catabolic process', 'T cell proliferation']
Histone-lysine N-methyltransferase 2C
1081
Histone-lysine N-methyltransferase 2C
1060
8.3
69
0.17
Q8NEZ4Q8NEZ4['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']
Isovaleryl-CoA dehydrogenase, mitochondrial
339
Isovaleryl-CoA dehydrogenase, mitochondrial
339
9.9
99
0.1
P26440P26440['branched-chain amino acid catabolic process', 'fatty acid beta-oxidation using acyl-CoA dehydrogenase', 'leucine catabolic process']['branched-chain amino acid catabolic process', 'fatty acid beta-oxidation using acyl-CoA dehydrogenase', 'leucine catabolic process']
Growth/differentiation factor 2
392
Growth/differentiation factor 2
356
8.6
83
0.14
Q9UK05Q9UK05['activin receptor signaling pathway', 'angiogenesis', 'blood vessel morphogenesis', 'BMP signaling pathway', 'branching involved in blood vessel morphogenesis', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'negative regulation of angiogenesis', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell growth', 'negative regulation of DNA biosynthetic process', 'negative regulation of DNA replication', 'negative regulation of endothelial cell migration', 'negative regulation of endothelial cell proliferation', 'ossification', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of angiogenesis', 'positive regulation of BMP signaling pathway', 'positive regulation of cartilage development', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of interleukin-8 production', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'SMAD protein signal transduction', 'transcription by RNA polymerase II', 'vasculogenesis']['activin receptor signaling pathway', 'angiogenesis', 'blood vessel morphogenesis', 'BMP signaling pathway', 'branching involved in blood vessel morphogenesis', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'negative regulation of angiogenesis', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell growth', 'negative regulation of DNA biosynthetic process', 'negative regulation of DNA replication', 'negative regulation of endothelial cell migration', 'negative regulation of endothelial cell proliferation', 'ossification', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of angiogenesis', 'positive regulation of BMP signaling pathway', 'positive regulation of cartilage development', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of interleukin-8 production', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'SMAD protein signal transduction', 'transcription by RNA polymerase II', 'vasculogenesis']
Isoform L-VEGF206 of Vascular endothelial growth factor A
257
Isoform L-VEGF206 of Vascular endothelial growth factor A
267
8.6
68
0.17
P15692-14P15692-14[][]
Trypsin-3
105
Protein AMBP
296
9.4
96
0.11
P35030P02760['antimicrobial humoral response', 'digestion', 'endothelial cell migration', 'proteolysis', 'zymogen activation']['cell adhesion', 'cellular oxidant detoxification', 'cellular response to reactive oxygen species', 'cytochrome c metabolic process', 'female pregnancy', 'heme catabolic process', 'hemoglobin metabolic process', 'negative regulation of immune response', 'negative regulation of JNK cascade', 'protein catabolic process']
Kunitz-type protease inhibitor 1
101
Suppressor of tumorigenicity 14 protein
641
9.4
88
0.12
H3BR01Q9Y5Y6[]['epithelial cell morphogenesis involved in placental branching', 'keratinocyte differentiation', 'neural tube closure', 'protein catabolic process', 'proteolysis']
Leucine carboxyl methyltransferase 1
136
Leucine carboxyl methyltransferase 1
136
9.4
63
0.17
Q9UIC8Q9UIC8['C-terminal protein methylation', 'G2/M transition of mitotic cell cycle', 'negative regulation of protein-containing complex assembly', 'protein methylation', 'protein modification process', 'regulation of apoptotic process', 'regulation of glucose metabolic process', 'regulation of mitotic cell cycle spindle assembly checkpoint']['C-terminal protein methylation', 'G2/M transition of mitotic cell cycle', 'negative regulation of protein-containing complex assembly', 'protein methylation', 'protein modification process', 'regulation of apoptotic process', 'regulation of glucose metabolic process', 'regulation of mitotic cell cycle spindle assembly checkpoint']
Serine/threonine-protein kinase TNNI3K
705
Serine/threonine-protein kinase TNNI3K
705
9.3
79
0.14
Q59H18Q59H18['bundle of His cell to Purkinje myocyte communication', 'protein phosphorylation', 'regulation of cardiac conduction', 'regulation of cardiac muscle contraction', 'regulation of heart rate', 'regulation of postsynapse organization']['bundle of His cell to Purkinje myocyte communication', 'protein phosphorylation', 'regulation of cardiac conduction', 'regulation of cardiac muscle contraction', 'regulation of heart rate', 'regulation of postsynapse organization']
Norrin
128
Norrin
95
9.3
78
0.14
Q00604Q00604['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']
Glutathione S-transferase Mu 1
87
Glutathione S-transferase Mu 1
87
9.3
72
0.15
P09488P09488['cellular detoxification of nitrogen compound', 'glutathione derivative biosynthetic process', 'glutathione metabolic process', 'hepoxilin biosynthetic process', 'nitrobenzene metabolic process', 'prostaglandin metabolic process', 'xenobiotic catabolic process']['cellular detoxification of nitrogen compound', 'glutathione derivative biosynthetic process', 'glutathione metabolic process', 'hepoxilin biosynthetic process', 'nitrobenzene metabolic process', 'prostaglandin metabolic process', 'xenobiotic catabolic process']
CD44 antigen
77
CD44 antigen
77
9.3
79
0.14
P16070P16070['cartilage development', 'cell adhesion', 'cell migration', 'cell-cell adhesion', 'cell-matrix adhesion', 'cellular response to fibroblast growth factor stimulus', 'cytokine-mediated signaling pathway', 'hyaluronan catabolic process', 'inflammatory response', 'monocyte aggregation', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of DNA damage response, signal transduction by p53 class mediator', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of monocyte aggregation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'regulation of lamellipodium morphogenesis', 'T cell activation', 'wound healing, spreading of cells']['cartilage development', 'cell adhesion', 'cell migration', 'cell-cell adhesion', 'cell-matrix adhesion', 'cellular response to fibroblast growth factor stimulus', 'cytokine-mediated signaling pathway', 'hyaluronan catabolic process', 'inflammatory response', 'monocyte aggregation', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of DNA damage response, signal transduction by p53 class mediator', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of monocyte aggregation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'regulation of lamellipodium morphogenesis', 'T cell activation', 'wound healing, spreading of cells']
Microtubule-associated serine/threonine-protein kinase 1
1015
Microtubule-associated serine/threonine-protein kinase 1
1015
10.0
70
0.14
Q9Y2H9Q9Y2H9['brain development', 'cytoskeleton organization', 'intracellular signal transduction', 'peptidyl-serine phosphorylation', 'protein phosphorylation']['brain development', 'cytoskeleton organization', 'intracellular signal transduction', 'peptidyl-serine phosphorylation', 'protein phosphorylation']
Mothers against decapentaplegic homolog 4
71
Mothers against decapentaplegic homolog 4
71
8.6
82
0.14
Q13485Q13485['activin receptor signaling pathway', 'adrenal gland development', 'aging', 'anatomical structure morphogenesis', 'atrioventricular canal development', 'atrioventricular valve formation', 'axon guidance', 'BMP signaling pathway', 'brainstem development', 'branching involved in ureteric bud morphogenesis', 'cardiac conduction system development', 'cell differentiation', 'cell population proliferation', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'cellular response to glucose stimulus', 'developmental growth', 'embryonic digit morphogenesis', 'endocardial cell differentiation', 'endothelial cell activation', 'epithelial to mesenchymal transition involved in endocardial cushion formation', 'ERK1 and ERK2 cascade', 'female gonad morphogenesis', 'formation of anatomical boundary', 'gastrulation with mouth forming second', 'in utero embryonic development', 'interleukin-6-mediated signaling pathway', 'intracellular signal transduction', 'left ventricular cardiac muscle tissue morphogenesis', 'mesendoderm development', 'metanephric mesenchyme morphogenesis', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of cardiac myofibril assembly', 'negative regulation of cell death', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of protein catabolic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'nephrogenic mesenchyme morphogenesis', 'neural crest cell differentiation', 'neuron fate commitment', 'osteoblast differentiation', 'outflow tract septum morphogenesis', 'ovarian follicle development', 'positive regulation of BMP signaling pathway', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of cell proliferation involved in heart valve morphogenesis', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of follicle-stimulating hormone secretion', 'positive regulation of histone H3-K4 methylation', 'positive regulation of histone H3-K9 acetylation', 'positive regulation of luteinizing hormone secretion', 'positive regulation of miRNA transcription', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta receptor signaling pathway', 'regulation of binding', 'regulation of hair follicle development', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to transforming growth factor beta', 'sebaceous gland development', 'secondary palate development', 'seminiferous tubule development', 'single fertilization', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'somite rostral/caudal axis specification', 'spermatogenesis', 'transcription by RNA polymerase II', 'transcription, DNA-templated', 'transforming growth factor beta receptor signaling pathway', 'uterus development', 'ventricular septum morphogenesis', 'wound healing']['activin receptor signaling pathway', 'adrenal gland development', 'aging', 'anatomical structure morphogenesis', 'atrioventricular canal development', 'atrioventricular valve formation', 'axon guidance', 'BMP signaling pathway', 'brainstem development', 'branching involved in ureteric bud morphogenesis', 'cardiac conduction system development', 'cell differentiation', 'cell population proliferation', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'cellular response to glucose stimulus', 'developmental growth', 'embryonic digit morphogenesis', 'endocardial cell differentiation', 'endothelial cell activation', 'epithelial to mesenchymal transition involved in endocardial cushion formation', 'ERK1 and ERK2 cascade', 'female gonad morphogenesis', 'formation of anatomical boundary', 'gastrulation with mouth forming second', 'in utero embryonic development', 'interleukin-6-mediated signaling pathway', 'intracellular signal transduction', 'left ventricular cardiac muscle tissue morphogenesis', 'mesendoderm development', 'metanephric mesenchyme morphogenesis', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of cardiac myofibril assembly', 'negative regulation of cell death', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of protein catabolic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'nephrogenic mesenchyme morphogenesis', 'neural crest cell differentiation', 'neuron fate commitment', 'osteoblast differentiation', 'outflow tract septum morphogenesis', 'ovarian follicle development', 'positive regulation of BMP signaling pathway', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of cell proliferation involved in heart valve morphogenesis', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of follicle-stimulating hormone secretion', 'positive regulation of histone H3-K4 methylation', 'positive regulation of histone H3-K9 acetylation', 'positive regulation of luteinizing hormone secretion', 'positive regulation of miRNA transcription', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta receptor signaling pathway', 'regulation of binding', 'regulation of hair follicle development', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to transforming growth factor beta', 'sebaceous gland development', 'secondary palate development', 'seminiferous tubule development', 'single fertilization', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'somite rostral/caudal axis specification', 'spermatogenesis', 'transcription by RNA polymerase II', 'transcription, DNA-templated', 'transforming growth factor beta receptor signaling pathway', 'uterus development', 'ventricular septum morphogenesis', 'wound healing']
Thioredoxin-interacting protein
247
Thioredoxin
73
8.6
89
0.13
Q9H3M7P10599['cell cycle', 'cellular response to tumor cell', 'keratinocyte differentiation', 'negative regulation of cell division', 'negative regulation of transcription by RNA polymerase II', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of apoptotic process', 'protein import into nucleus', 'protein transport', 'regulation of cell population proliferation', 'response to calcium ion', 'response to estradiol', 'response to glucose', 'response to hydrogen peroxide', 'response to mechanical stimulus', 'response to progesterone', 'response to xenobiotic stimulus']['activation of protein kinase B activity', 'cell redox homeostasis', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of protein export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA binding', 'positive regulation of peptidyl-cysteine S-nitrosylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'response to nitric oxide', 'response to radiation']
Glutamate receptor 3
85
Glutamate receptor 3
85
8.6
72
0.16
P19492P19492['regulation of receptor recycling', 'response to fungicide', 'response to lithium ion']['regulation of receptor recycling', 'response to fungicide', 'response to lithium ion']
Lymphokine-activated killer T-cell-originated protein kinase
70
Lymphokine-activated killer T-cell-originated protein kinase
70
8.3
42
0.29
Q96KB5Q96KB5['cellular response to UV', 'mitotic cell cycle', 'negative regulation of inflammatory response', 'negative regulation of proteasomal ubiquitin-dependent protein catabolic process', 'negative regulation of protein phosphorylation', 'negative regulation of stress-activated MAPK cascade', 'p38MAPK cascade', 'peptidyl-serine phosphorylation', 'positive regulation of mitotic DNA damage checkpoint', 'proteasome-mediated ubiquitin-dependent protein catabolic process']['cellular response to UV', 'mitotic cell cycle', 'negative regulation of inflammatory response', 'negative regulation of proteasomal ubiquitin-dependent protein catabolic process', 'negative regulation of protein phosphorylation', 'negative regulation of stress-activated MAPK cascade', 'p38MAPK cascade', 'peptidyl-serine phosphorylation', 'positive regulation of mitotic DNA damage checkpoint', 'proteasome-mediated ubiquitin-dependent protein catabolic process']
Suppressor of tumorigenicity 14 protein
657
Pancreatic trypsin inhibitor
49
8.3
100
0.12
Q9Y5Y6P00974['epithelial cell morphogenesis involved in placental branching', 'keratinocyte differentiation', 'neural tube closure', 'protein catabolic process', 'proteolysis']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Elongin-C
112
von Hippel-Lindau disease tumor suppressor
162
8.3
nan
nan
Q2KII4P40337['protein ubiquitination', 'transcription initiation from RNA polymerase II promoter', 'ubiquitin-dependent protein catabolic process']['cell morphogenesis', 'negative regulation of apoptotic process', 'negative regulation of cell population proliferation', 'negative regulation of gene expression', 'negative regulation of receptor signaling pathway via JAK-STAT', 'negative regulation of transcription elongation from RNA polymerase II promoter', 'negative regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of cell differentiation', 'positive regulation of transcription, DNA-templated', 'protein stabilization', 'protein ubiquitination', 'proteolysis', 'regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'regulation of transcription, DNA-templated']
Caspase-1
136
Caspase-1
364
9.9
54
0.19
P29466P29466['apoptotic process', 'cellular response to interferon-gamma', 'cellular response to lipopolysaccharide', 'cellular response to mechanical stimulus', 'cellular response to organic substance', 'cytokine precursor processing', 'defense response to virus', 'icosanoid biosynthetic process', 'osmosensory signaling pathway', 'pattern recognition receptor signaling pathway', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of tumor necrosis factor-mediated signaling pathway', 'protein autoprocessing', 'proteolysis', 'pyroptosis', 'regulation of apoptotic process', 'regulation of inflammatory response', 'signal transduction', 'signaling receptor ligand precursor processing']['apoptotic process', 'cellular response to interferon-gamma', 'cellular response to lipopolysaccharide', 'cellular response to mechanical stimulus', 'cellular response to organic substance', 'cytokine precursor processing', 'defense response to virus', 'icosanoid biosynthetic process', 'osmosensory signaling pathway', 'pattern recognition receptor signaling pathway', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of tumor necrosis factor-mediated signaling pathway', 'protein autoprocessing', 'proteolysis', 'pyroptosis', 'regulation of apoptotic process', 'regulation of inflammatory response', 'signal transduction', 'signaling receptor ligand precursor processing']
Tumor necrosis factor receptor superfamily member 9
47
Tumor necrosis factor receptor superfamily member 9
44
9.9
85
0.12
P20334P20334['apoptotic process', 'negative regulation of cell population proliferation', 'regulation of cell population proliferation', 'regulation of immature T cell proliferation in thymus']['apoptotic process', 'negative regulation of cell population proliferation', 'regulation of cell population proliferation', 'regulation of immature T cell proliferation in thymus']
Protein fem-1 homolog C
357
Protein fem-1 homolog C
357
9.4
74
0.14
Q96JP0Q96JP0['proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination', 'ubiquitin-dependent protein catabolic process', 'ubiquitin-dependent protein catabolic process via the C-end degron rule pathway']['proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination', 'ubiquitin-dependent protein catabolic process', 'ubiquitin-dependent protein catabolic process via the C-end degron rule pathway']
Glucocorticoid receptor
463
Glucocorticoid receptor
457
9.3
56
0.19
P04150P04150['adrenal gland development', 'apoptotic process', 'cell cycle', 'cell division', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin organization', 'chromosome segregation', 'glucocorticoid metabolic process', 'intracellular steroid hormone receptor signaling pathway', 'mammary gland duct morphogenesis', 'maternal behavior', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'signal transduction']['adrenal gland development', 'apoptotic process', 'cell cycle', 'cell division', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin organization', 'chromosome segregation', 'glucocorticoid metabolic process', 'intracellular steroid hormone receptor signaling pathway', 'mammary gland duct morphogenesis', 'maternal behavior', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'signal transduction']
Fibrinogen alpha chain
180
Fibrinogen beta chain
223
3.1
78
0.42
P02671P02675['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']
Myosin-7
947
Myosin-7
947
2.1
52
0.91
P12883P12883['adult heart development', 'ATP metabolic process', 'cardiac muscle contraction', 'cardiac muscle hypertrophy in response to stress', 'muscle contraction', 'muscle filament sliding', 'regulation of heart rate', 'regulation of slow-twitch skeletal muscle fiber contraction', 'regulation of the force of heart contraction', 'regulation of the force of skeletal muscle contraction', 'sarcomere organization', 'skeletal muscle contraction', 'striated muscle contraction', 'transition between fast and slow fiber', 'ventricular cardiac muscle tissue morphogenesis']['adult heart development', 'ATP metabolic process', 'cardiac muscle contraction', 'cardiac muscle hypertrophy in response to stress', 'muscle contraction', 'muscle filament sliding', 'regulation of heart rate', 'regulation of slow-twitch skeletal muscle fiber contraction', 'regulation of the force of heart contraction', 'regulation of the force of skeletal muscle contraction', 'sarcomere organization', 'skeletal muscle contraction', 'striated muscle contraction', 'transition between fast and slow fiber', 'ventricular cardiac muscle tissue morphogenesis']
Ubiquitin-conjugating enzyme E2 S
118
Ubiquitin-conjugating enzyme E2 S
118
2.1
75
0.63
Q16763Q16763['anaphase-promoting complex-dependent catabolic process', 'cell division', 'exit from mitosis', 'free ubiquitin chain polymerization', 'positive regulation of ubiquitin protein ligase activity', 'protein K11-linked ubiquitination', 'protein K27-linked ubiquitination', 'protein K29-linked ubiquitination', 'protein K6-linked ubiquitination', 'protein K63-linked ubiquitination', 'protein modification process', 'protein polyubiquitination', 'ubiquitin-dependent protein catabolic process']['anaphase-promoting complex-dependent catabolic process', 'cell division', 'exit from mitosis', 'free ubiquitin chain polymerization', 'positive regulation of ubiquitin protein ligase activity', 'protein K11-linked ubiquitination', 'protein K27-linked ubiquitination', 'protein K29-linked ubiquitination', 'protein K6-linked ubiquitination', 'protein K63-linked ubiquitination', 'protein modification process', 'protein polyubiquitination', 'ubiquitin-dependent protein catabolic process']
Acrosin
160
Acrosin
26
2.1
81
0.59
P08001P08001['acrosome reaction', 'activation of adenylate cyclase activity', 'proteolysis', 'single fertilization']['acrosome reaction', 'activation of adenylate cyclase activity', 'proteolysis', 'single fertilization']
Thioredoxin-interacting protein
63
Thioredoxin-interacting protein
63
2.1
70
0.68
Q9H3M7Q9H3M7['cell cycle', 'cellular response to tumor cell', 'keratinocyte differentiation', 'negative regulation of cell division', 'negative regulation of transcription by RNA polymerase II', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of apoptotic process', 'protein import into nucleus', 'protein transport', 'regulation of cell population proliferation', 'response to calcium ion', 'response to estradiol', 'response to glucose', 'response to hydrogen peroxide', 'response to mechanical stimulus', 'response to progesterone', 'response to xenobiotic stimulus']['cell cycle', 'cellular response to tumor cell', 'keratinocyte differentiation', 'negative regulation of cell division', 'negative regulation of transcription by RNA polymerase II', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of apoptotic process', 'protein import into nucleus', 'protein transport', 'regulation of cell population proliferation', 'response to calcium ion', 'response to estradiol', 'response to glucose', 'response to hydrogen peroxide', 'response to mechanical stimulus', 'response to progesterone', 'response to xenobiotic stimulus']
RNA-binding protein 12
887
RNA-binding protein 12
887
2.1
81
0.59
Q9NTZ6Q9NTZ6['regulation of RNA splicing']['regulation of RNA splicing']
Vascular endothelial growth factor A
86
Vascular endothelial growth factor A
77
2.1
74
0.64
P15692P15692['activation of protein kinase activity', 'angiogenesis', 'artery morphogenesis', 'basophil chemotaxis', 'branching involved in blood vessel morphogenesis', 'camera-type eye morphogenesis', 'cardiac muscle cell development', 'cardiac vascular smooth muscle cell development', 'cell maturation', 'cell migration involved in sprouting angiogenesis', 'cellular response to hypoxia', 'cellular response to vascular endothelial growth factor stimulus', 'cellular stress response to acid chemical', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'coronary vein morphogenesis', 'dopaminergic neuron differentiation', 'endothelial cell chemotaxis', 'epithelial cell differentiation', 'eye photoreceptor cell development', 'heart morphogenesis', 'in utero embryonic development', 'induction of positive chemotaxis', 'kidney development', 'lactation', 'lung development', 'lymph vessel morphogenesis', 'macrophage differentiation', 'mammary gland alveolus development', 'mesoderm development', 'monocyte differentiation', 'motor neuron migration', 'negative regulation of adherens junction organization', 'negative regulation of apoptotic process', 'negative regulation of blood-brain barrier permeability', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of establishment of endothelial barrier', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'outflow tract morphogenesis', 'ovarian follicle development', 'positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell migration by vascular endothelial growth factor signaling pathway', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway', 'positive regulation of cold-induced thermogenesis', 'positive regulation of CREB transcription factor activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of histone deacetylase activity', 'positive regulation of leukocyte migration', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of neuroblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of positive chemotaxis', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C signaling', 'positive regulation of protein kinase D signaling', 'positive regulation of protein localization to early endosome', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor internalization', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of trophoblast cell migration', 'positive regulation of vascular permeability', 'post-embryonic camera-type eye development', 'primitive erythrocyte differentiation', 'regulation of cell shape', 'regulation of nitric oxide mediated signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of transcription by RNA polymerase II', 'response to hypoxia', 'sprouting angiogenesis', 'surfactant homeostasis', 'tube formation', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway']['activation of protein kinase activity', 'angiogenesis', 'artery morphogenesis', 'basophil chemotaxis', 'branching involved in blood vessel morphogenesis', 'camera-type eye morphogenesis', 'cardiac muscle cell development', 'cardiac vascular smooth muscle cell development', 'cell maturation', 'cell migration involved in sprouting angiogenesis', 'cellular response to hypoxia', 'cellular response to vascular endothelial growth factor stimulus', 'cellular stress response to acid chemical', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'coronary vein morphogenesis', 'dopaminergic neuron differentiation', 'endothelial cell chemotaxis', 'epithelial cell differentiation', 'eye photoreceptor cell development', 'heart morphogenesis', 'in utero embryonic development', 'induction of positive chemotaxis', 'kidney development', 'lactation', 'lung development', 'lymph vessel morphogenesis', 'macrophage differentiation', 'mammary gland alveolus development', 'mesoderm development', 'monocyte differentiation', 'motor neuron migration', 'negative regulation of adherens junction organization', 'negative regulation of apoptotic process', 'negative regulation of blood-brain barrier permeability', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of establishment of endothelial barrier', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'outflow tract morphogenesis', 'ovarian follicle development', 'positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell migration by vascular endothelial growth factor signaling pathway', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway', 'positive regulation of cold-induced thermogenesis', 'positive regulation of CREB transcription factor activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of histone deacetylase activity', 'positive regulation of leukocyte migration', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of neuroblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of positive chemotaxis', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C signaling', 'positive regulation of protein kinase D signaling', 'positive regulation of protein localization to early endosome', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor internalization', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of trophoblast cell migration', 'positive regulation of vascular permeability', 'post-embryonic camera-type eye development', 'primitive erythrocyte differentiation', 'regulation of cell shape', 'regulation of nitric oxide mediated signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of transcription by RNA polymerase II', 'response to hypoxia', 'sprouting angiogenesis', 'surfactant homeostasis', 'tube formation', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway']
Galactokinase
391
Galactokinase
391
2.1
56
0.84
P51570P51570['galactitol metabolic process', 'galactose catabolic process', 'galactose catabolic process via UDP-galactose', 'galactose metabolic process', 'glycolytic process from galactose']['galactitol metabolic process', 'galactose catabolic process', 'galactose catabolic process via UDP-galactose', 'galactose metabolic process', 'glycolytic process from galactose']
Chromobox protein homolog 3
69
Chromobox protein homolog 3
69
2.1
82
0.57
Q13185Q13185['cellular response to DNA damage stimulus', 'chromatin organization', 'chromatin remodeling', 'heterochromatin assembly', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'rhythmic process']['cellular response to DNA damage stimulus', 'chromatin organization', 'chromatin remodeling', 'heterochromatin assembly', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'rhythmic process']
Caspase-2
436
Caspase-2
436
2.1
84
0.56
P42575P42575['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'aging', 'apoptotic process', 'apoptotic signaling pathway', 'brain development', 'cellular response to DNA damage stimulus', 'cellular response to mechanical stimulus', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'ectopic germ cell programmed cell death', 'execution phase of apoptosis', 'extrinsic apoptotic signaling pathway in absence of ligand', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'luteolysis', 'negative regulation of apoptotic process', 'negative regulation of necroptotic process', 'neural retina development', 'positive regulation of apoptotic process', 'positive regulation of apoptotic signaling pathway', 'positive regulation of neuron apoptotic process', 'protein processing', 'release of cytochrome c from mitochondria']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'aging', 'apoptotic process', 'apoptotic signaling pathway', 'brain development', 'cellular response to DNA damage stimulus', 'cellular response to mechanical stimulus', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'ectopic germ cell programmed cell death', 'execution phase of apoptosis', 'extrinsic apoptotic signaling pathway in absence of ligand', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'luteolysis', 'negative regulation of apoptotic process', 'negative regulation of necroptotic process', 'neural retina development', 'positive regulation of apoptotic process', 'positive regulation of apoptotic signaling pathway', 'positive regulation of neuron apoptotic process', 'protein processing', 'release of cytochrome c from mitochondria']
Coagulation factor IX
178
Coagulation factor IX
335
2.1
85
0.55
P00740P00740['blood coagulation', 'blood coagulation, intrinsic pathway', 'proteolysis', 'zymogen activation']['blood coagulation', 'blood coagulation, intrinsic pathway', 'proteolysis', 'zymogen activation']
Xaa-Pro dipeptidase
58
Xaa-Pro dipeptidase
158
2.1
64
0.74
1
✔P12955P12955['cellular amino acid metabolic process', 'collagen catabolic process', 'proteolysis']['cellular amino acid metabolic process', 'collagen catabolic process', 'proteolysis']
Procathepsin L
269
Procathepsin L
322
2.1
69
0.68
P07711P07711['adaptive immune response', 'antigen processing and presentation', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'antigen processing and presentation of peptide antigen', 'CD4-positive, alpha-beta T cell lineage commitment', 'cellular response to thyroid hormone stimulus', 'collagen catabolic process', 'elastin catabolic process', 'enkephalin processing', 'fusion of virus membrane with host endosome membrane', 'fusion of virus membrane with host plasma membrane', 'immune response', 'macrophage apoptotic process', 'protein autoprocessing', 'proteolysis', 'proteolysis involved in protein catabolic process', 'receptor-mediated endocytosis of virus by host cell', 'viral entry into host cell', 'zymogen activation']['adaptive immune response', 'antigen processing and presentation', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'antigen processing and presentation of peptide antigen', 'CD4-positive, alpha-beta T cell lineage commitment', 'cellular response to thyroid hormone stimulus', 'collagen catabolic process', 'elastin catabolic process', 'enkephalin processing', 'fusion of virus membrane with host endosome membrane', 'fusion of virus membrane with host plasma membrane', 'immune response', 'macrophage apoptotic process', 'protein autoprocessing', 'proteolysis', 'proteolysis involved in protein catabolic process', 'receptor-mediated endocytosis of virus by host cell', 'viral entry into host cell', 'zymogen activation']
Insulin
109
Insulin
43
2.1
57
0.83
P01308P01308['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']
Parkinson disease protein 7
53
Parkinson disease protein 7
53
3.0
76
0.43
1
✔Q99497Q99497['activation of protein kinase B activity', 'adult locomotory behavior', 'autophagy', 'cellular detoxification of aldehyde', 'cellular detoxification of methylglyoxal', 'cellular response to glyoxal', 'cellular response to hydrogen peroxide', 'cellular response to oxidative stress', 'detection of oxidative stress', 'detoxification of copper ion', 'detoxification of mercury ion', 'DNA repair', 'dopamine uptake involved in synaptic transmission', 'glucose homeostasis', 'glutathione deglycation', 'glycolate biosynthetic process', 'glyoxal metabolic process', 'guanine deglycation', 'guanine deglycation, glyoxal removal', 'guanine deglycation, methylglyoxal removal', 'histone modification', 'hydrogen peroxide metabolic process', 'inflammatory response', 'insulin secretion', 'lactate biosynthetic process', 'membrane depolarization', 'membrane hyperpolarization', 'methylglyoxal catabolic process to lactate', 'methylglyoxal metabolic process', 'mitochondrion organization', 'negative regulation of apoptotic process', 'negative regulation of cell death', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'negative regulation of death-inducing signaling complex assembly', 'negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of gene expression', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of hydrogen peroxide-induced neuron death', 'negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of neuron apoptotic process', 'negative regulation of neuron death', 'negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of oxidative stress-induced cell death', 'negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of proteasomal ubiquitin-dependent protein catabolic process', 'negative regulation of protein acetylation', 'negative regulation of protein binding', 'negative regulation of protein export from nucleus', 'negative regulation of protein K48-linked deubiquitination', 'negative regulation of protein kinase activity', 'negative regulation of protein phosphorylation', 'negative regulation of protein sumoylation', 'negative regulation of protein ubiquitination', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of TRAIL-activated apoptotic signaling pathway', 'negative regulation of ubiquitin-protein transferase activity', 'negative regulation of ubiquitin-specific protease activity', 'peptidyl-arginine deglycation', 'peptidyl-cysteine deglycation', 'peptidyl-lysine deglycation', 'positive regulation of acute inflammatory response to antigenic stimulus', 'positive regulation of androgen receptor activity', 'positive regulation of autophagy of mitochondrion', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of dopamine biosynthetic process', 'positive regulation of gene expression', 'positive regulation of interleukin-8 production', 'positive regulation of L-dopa biosynthetic process', 'positive regulation of L-dopa decarboxylase activity', 'positive regulation of mitochondrial electron transport, NADH to ubiquinone', 'positive regulation of NAD(P)H oxidase activity', 'positive regulation of oxidative phosphorylation uncoupler activity', 'positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein-containing complex assembly', 'positive regulation of pyrroline-5-carboxylate reductase activity', 'positive regulation of reactive oxygen species biosynthetic process', 'positive regulation of superoxide dismutase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of tyrosine 3-monooxygenase activity', 'protein deglycation, glyoxal removal', 'protein deglycation, methylglyoxal removal', 'protein deglycosylation', 'protein stabilization', 'proteolysis', 'Ras protein signal transduction', 'regulation of androgen receptor signaling pathway', 'regulation of histone acetylation', 'regulation of histone ubiquitination', 'regulation of inflammatory response', 'regulation of mitochondrial membrane potential', 'regulation of neuron apoptotic process', 'regulation of supramolecular fiber organization', 'response to oxidative stress', 'single fertilization']['activation of protein kinase B activity', 'adult locomotory behavior', 'autophagy', 'cellular detoxification of aldehyde', 'cellular detoxification of methylglyoxal', 'cellular response to glyoxal', 'cellular response to hydrogen peroxide', 'cellular response to oxidative stress', 'detection of oxidative stress', 'detoxification of copper ion', 'detoxification of mercury ion', 'DNA repair', 'dopamine uptake involved in synaptic transmission', 'glucose homeostasis', 'glutathione deglycation', 'glycolate biosynthetic process', 'glyoxal metabolic process', 'guanine deglycation', 'guanine deglycation, glyoxal removal', 'guanine deglycation, methylglyoxal removal', 'histone modification', 'hydrogen peroxide metabolic process', 'inflammatory response', 'insulin secretion', 'lactate biosynthetic process', 'membrane depolarization', 'membrane hyperpolarization', 'methylglyoxal catabolic process to lactate', 'methylglyoxal metabolic process', 'mitochondrion organization', 'negative regulation of apoptotic process', 'negative regulation of cell death', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'negative regulation of death-inducing signaling complex assembly', 'negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of gene expression', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of hydrogen peroxide-induced neuron death', 'negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of neuron apoptotic process', 'negative regulation of neuron death', 'negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of oxidative stress-induced cell death', 'negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of proteasomal ubiquitin-dependent protein catabolic process', 'negative regulation of protein acetylation', 'negative regulation of protein binding', 'negative regulation of protein export from nucleus', 'negative regulation of protein K48-linked deubiquitination', 'negative regulation of protein kinase activity', 'negative regulation of protein phosphorylation', 'negative regulation of protein sumoylation', 'negative regulation of protein ubiquitination', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of TRAIL-activated apoptotic signaling pathway', 'negative regulation of ubiquitin-protein transferase activity', 'negative regulation of ubiquitin-specific protease activity', 'peptidyl-arginine deglycation', 'peptidyl-cysteine deglycation', 'peptidyl-lysine deglycation', 'positive regulation of acute inflammatory response to antigenic stimulus', 'positive regulation of androgen receptor activity', 'positive regulation of autophagy of mitochondrion', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of dopamine biosynthetic process', 'positive regulation of gene expression', 'positive regulation of interleukin-8 production', 'positive regulation of L-dopa biosynthetic process', 'positive regulation of L-dopa decarboxylase activity', 'positive regulation of mitochondrial electron transport, NADH to ubiquinone', 'positive regulation of NAD(P)H oxidase activity', 'positive regulation of oxidative phosphorylation uncoupler activity', 'positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein-containing complex assembly', 'positive regulation of pyrroline-5-carboxylate reductase activity', 'positive regulation of reactive oxygen species biosynthetic process', 'positive regulation of superoxide dismutase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of tyrosine 3-monooxygenase activity', 'protein deglycation, glyoxal removal', 'protein deglycation, methylglyoxal removal', 'protein deglycosylation', 'protein stabilization', 'proteolysis', 'Ras protein signal transduction', 'regulation of androgen receptor signaling pathway', 'regulation of histone acetylation', 'regulation of histone ubiquitination', 'regulation of inflammatory response', 'regulation of mitochondrial membrane potential', 'regulation of neuron apoptotic process', 'regulation of supramolecular fiber organization', 'response to oxidative stress', 'single fertilization']
D-3-phosphoglycerate dehydrogenase
116
D-3-phosphoglycerate dehydrogenase
116
3.0
99
0.33
O43175O43175['brain development', 'G1 to G0 transition', 'gamma-aminobutyric acid metabolic process', 'glial cell development', 'glutamine metabolic process', 'glycine metabolic process', 'L-serine biosynthetic process', 'neural tube development', 'neuron projection development', 'regulation of gene expression', 'spinal cord development', 'taurine metabolic process', 'threonine metabolic process']['brain development', 'G1 to G0 transition', 'gamma-aminobutyric acid metabolic process', 'glial cell development', 'glutamine metabolic process', 'glycine metabolic process', 'L-serine biosynthetic process', 'neural tube development', 'neuron projection development', 'regulation of gene expression', 'spinal cord development', 'taurine metabolic process', 'threonine metabolic process']
Interleukin-23 subunit alpha
73
Interleukin-12 subunit beta
199
3.0
50
0.66
Q9NPF7P29460['defense response to Gram-negative bacterium', 'defense response to virus', 'immune response', 'inflammatory response', 'innate immune response', 'negative regulation of interleukin-10 production', 'positive regulation of activated T cell proliferation', 'positive regulation of activation of Janus kinase activity', 'positive regulation of defense response to virus by host', 'positive regulation of granulocyte macrophage colony-stimulating factor production', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-10 production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-17 production', 'positive regulation of memory T cell differentiation', 'positive regulation of natural killer cell activation', 'positive regulation of natural killer cell proliferation', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of NK T cell activation', 'positive regulation of NK T cell proliferation', 'positive regulation of osteoclast differentiation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of T cell proliferation', 'positive regulation of T-helper 1 type immune response', 'positive regulation of T-helper 17 cell lineage commitment', 'positive regulation of T-helper 17 type immune response', 'positive regulation of tissue remodeling', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'positive regulation of tyrosine phosphorylation of STAT protein', 'regulation of tyrosine phosphorylation of STAT protein', 'T cell proliferation', 'tissue remodeling']['cell migration', 'cellular response to interferon-gamma', 'cellular response to lipopolysaccharide', 'cytokine-mediated signaling pathway', 'defense response to Gram-negative bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'natural killer cell activation', 'natural killer cell activation involved in immune response', 'negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'negative regulation of inflammatory response to antigenic stimulus', 'negative regulation of interleukin-10 production', 'negative regulation of interleukin-17 production', 'negative regulation of protein secretion', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of vascular endothelial growth factor signaling pathway', 'positive regulation of activated T cell proliferation', 'positive regulation of activation of Janus kinase activity', 'positive regulation of cell adhesion', 'positive regulation of defense response to virus by host', 'positive regulation of granulocyte macrophage colony-stimulating factor production', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-10 production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-17 production', 'positive regulation of lymphocyte proliferation', 'positive regulation of memory T cell differentiation', 'positive regulation of mononuclear cell proliferation', 'positive regulation of natural killer cell activation', 'positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target', 'positive regulation of natural killer cell proliferation', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of NK T cell activation', 'positive regulation of NK T cell proliferation', 'positive regulation of osteoclast differentiation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell apoptotic process', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of T cell proliferation', 'positive regulation of T-helper 1 type immune response', 'positive regulation of T-helper 17 cell lineage commitment', 'positive regulation of T-helper 17 type immune response', 'positive regulation of tissue remodeling', 'positive regulation of tumor necrosis factor production', 'positive regulation of tyrosine phosphorylation of STAT protein', 'regulation of cytokine production', 'regulation of tyrosine phosphorylation of STAT protein', 'response to UV-B', 'sensory perception of pain', 'sexual reproduction', 'T cell proliferation', 'T-helper 1 type immune response', 'T-helper cell differentiation']
Coagulation factor X
342
Coagulation factor X
172
2.5
83
0.47
P00742P00742['blood coagulation', 'blood coagulation, common pathway', 'positive regulation of cell migration', 'positive regulation of protein kinase B signaling', 'proteolysis', 'zymogen activation']['blood coagulation', 'blood coagulation, common pathway', 'positive regulation of cell migration', 'positive regulation of protein kinase B signaling', 'proteolysis', 'zymogen activation']
Peroxiredoxin-1
52
Sulfiredoxin-1
99
2.1
72
0.66
Q06830Q9BYN0['cell population proliferation', 'cell redox homeostasis', 'erythrocyte homeostasis', 'fibroblast proliferation', 'hydrogen peroxide catabolic process', 'leukocyte activation', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'regulation of NIK/NF-kappaB signaling', 'regulation of stress-activated MAPK cascade', 'removal of superoxide radicals', 'retina homeostasis', 'skeletal system development']['cellular response to oxidative stress', 'response to oxidative stress']
Human nkt tcr alpha chain
164
Human nkt tcr beta chain
176
2.1
76
0.62
K7N5M3K7N5M4[][]
TP53-binding protein 1
1525
TP53-binding protein 1
1525
2.1
87
0.54
Q12888Q12888['cellular response to DNA damage stimulus', 'cellular response to X-ray', 'DNA damage checkpoint signaling', 'double-strand break repair via nonhomologous end joining', 'negative regulation of double-strand break repair via homologous recombination', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of isotype switching', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein homooligomerization']['cellular response to DNA damage stimulus', 'cellular response to X-ray', 'DNA damage checkpoint signaling', 'double-strand break repair via nonhomologous end joining', 'negative regulation of double-strand break repair via homologous recombination', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of isotype switching', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein homooligomerization']
Fibrinogen alpha chain
184
Fibrinogen beta chain
223
2.1
66
0.72
P02671P02675['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']
Peroxiredoxin-2
51
Peroxiredoxin-2
172
2.1
61
0.78
1
✔P32119P32119['cell redox homeostasis', 'cellular response to oxidative stress', 'defense response to tumor cell', 'extrinsic apoptotic signaling pathway', 'hydrogen peroxide catabolic process', 'leukocyte activation', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of lipopolysaccharide-mediated signaling pathway', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of T cell differentiation', 'positive regulation of blood coagulation', 'positive regulation of MAPK cascade', 'regulation of apoptotic process', 'regulation of hydrogen peroxide metabolic process', 'removal of superoxide radicals', 'respiratory burst involved in inflammatory response', 'response to lipopolysaccharide', 'response to oxidative stress', 'T cell homeostasis', 'T cell proliferation', 'thymus development']['cell redox homeostasis', 'cellular response to oxidative stress', 'defense response to tumor cell', 'extrinsic apoptotic signaling pathway', 'hydrogen peroxide catabolic process', 'leukocyte activation', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of lipopolysaccharide-mediated signaling pathway', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of T cell differentiation', 'positive regulation of blood coagulation', 'positive regulation of MAPK cascade', 'regulation of apoptotic process', 'regulation of hydrogen peroxide metabolic process', 'removal of superoxide radicals', 'respiratory burst involved in inflammatory response', 'response to lipopolysaccharide', 'response to oxidative stress', 'T cell homeostasis', 'T cell proliferation', 'thymus development']
Fibrinogen beta chain
227
Fibrinogen gamma chain
165
2.1
65
0.74
P02675P02679['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Plexin-C1
1227
Plexin-C1
1227
2.1
74
0.65
O60486O60486['cell adhesion', 'negative regulation of cell adhesion', 'positive regulation of axonogenesis', 'regulation of cell migration', 'regulation of cell shape', 'regulation of GTPase activity', 'semaphorin-plexin signaling pathway involved in axon guidance']['cell adhesion', 'negative regulation of cell adhesion', 'positive regulation of axonogenesis', 'regulation of cell migration', 'regulation of cell shape', 'regulation of GTPase activity', 'semaphorin-plexin signaling pathway involved in axon guidance']
Glandular kallikrein
14
Glandular kallikrein
158
2.1
65
0.73
P00752P00752['regulation of systemic arterial blood pressure', 'zymogen activation']['regulation of systemic arterial blood pressure', 'zymogen activation']
Complement C1r subcomponent
451
Complement C1r subcomponent
577
2.1
76
0.63
P00736P00736['complement activation, classical pathway', 'immune response', 'innate immune response', 'zymogen activation']['complement activation, classical pathway', 'immune response', 'innate immune response', 'zymogen activation']
Integrator complex subunit 11
542
Integrator complex subunit 11
542
2.1
57
0.83
Q5TA45Q5TA45['regulation of transcription elongation from RNA polymerase II promoter', 'snRNA processing']['regulation of transcription elongation from RNA polymerase II promoter', 'snRNA processing']
Potassium channel subfamily K member 4
52
Potassium channel subfamily K member 4
52
2.1
84
0.56
Q9NYG8Q9NYG8['cellular response to alkaline pH', 'cellular response to fatty acid', 'cellular response to mechanical stimulus', 'cellular response to temperature stimulus', 'detection of mechanical stimulus involved in sensory perception of touch', 'memory', 'potassium ion transmembrane transport', 'potassium ion transport', 'regulation of ion transmembrane transport', 'sensory perception of pain', 'sensory perception of temperature stimulus', 'stabilization of membrane potential']['cellular response to alkaline pH', 'cellular response to fatty acid', 'cellular response to mechanical stimulus', 'cellular response to temperature stimulus', 'detection of mechanical stimulus involved in sensory perception of touch', 'memory', 'potassium ion transmembrane transport', 'potassium ion transport', 'regulation of ion transmembrane transport', 'sensory perception of pain', 'sensory perception of temperature stimulus', 'stabilization of membrane potential']
Ubiquitin-like protein ISG15
78
Ubiquitin-like protein ISG15
78
2.1
52
0.91
P05161P05161['defense response to bacterium', 'defense response to virus', 'integrin-mediated signaling pathway', 'ISG15-protein conjugation', 'modification-dependent protein catabolic process', 'negative regulation of protein ubiquitination', 'negative regulation of type I interferon-mediated signaling pathway', 'negative regulation of viral genome replication', 'positive regulation of bone mineralization', 'positive regulation of erythrocyte differentiation', 'positive regulation of interferon-beta production', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-10 production', 'positive regulation of protein oligomerization', 'protein localization to mitochondrion', 'regulation of interferon-gamma production', 'response to type I interferon', 'response to virus']['defense response to bacterium', 'defense response to virus', 'integrin-mediated signaling pathway', 'ISG15-protein conjugation', 'modification-dependent protein catabolic process', 'negative regulation of protein ubiquitination', 'negative regulation of type I interferon-mediated signaling pathway', 'negative regulation of viral genome replication', 'positive regulation of bone mineralization', 'positive regulation of erythrocyte differentiation', 'positive regulation of interferon-beta production', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-10 production', 'positive regulation of protein oligomerization', 'protein localization to mitochondrion', 'regulation of interferon-gamma production', 'response to type I interferon', 'response to virus']
Sorting nexin-11
55
Sorting nexin-11
138
2.1
75
0.63
Q9Y5W9Q9Y5W9['intracellular protein transport', 'vesicle organization']['intracellular protein transport', 'vesicle organization']
Coagulation factor VII
195
Coagulation factor VII
322
2.1
83
0.57
P08709P08709['activation of blood coagulation via clotting cascade', 'animal organ regeneration', 'blood coagulation', 'blood coagulation, extrinsic pathway', 'blood coagulation, fibrin clot formation', 'blood coagulation, intrinsic pathway', 'circadian rhythm', 'positive regulation of blood coagulation', 'positive regulation of cell migration', 'positive regulation of leukocyte chemotaxis', 'positive regulation of platelet-derived growth factor receptor signaling pathway', 'positive regulation of positive chemotaxis', 'positive regulation of protein kinase B signaling', 'protein processing', 'proteolysis', 'response to 2,3,7,8-tetrachlorodibenzodioxine', 'response to anticoagulant', 'response to astaxanthin', 'response to carbon dioxide', 'response to cholesterol', 'response to estradiol', 'response to estrogen', 'response to genistein', 'response to growth hormone', 'response to hypoxia', 'response to Thyroid stimulating hormone', 'response to thyrotropin-releasing hormone', 'response to thyroxine', 'response to vitamin K', 'response to wounding', 'zymogen activation']['activation of blood coagulation via clotting cascade', 'animal organ regeneration', 'blood coagulation', 'blood coagulation, extrinsic pathway', 'blood coagulation, fibrin clot formation', 'blood coagulation, intrinsic pathway', 'circadian rhythm', 'positive regulation of blood coagulation', 'positive regulation of cell migration', 'positive regulation of leukocyte chemotaxis', 'positive regulation of platelet-derived growth factor receptor signaling pathway', 'positive regulation of positive chemotaxis', 'positive regulation of protein kinase B signaling', 'protein processing', 'proteolysis', 'response to 2,3,7,8-tetrachlorodibenzodioxine', 'response to anticoagulant', 'response to astaxanthin', 'response to carbon dioxide', 'response to cholesterol', 'response to estradiol', 'response to estrogen', 'response to genistein', 'response to growth hormone', 'response to hypoxia', 'response to Thyroid stimulating hormone', 'response to thyrotropin-releasing hormone', 'response to thyroxine', 'response to vitamin K', 'response to wounding', 'zymogen activation']
Chymotrypsinogen A
136
Chymotrypsinogen A
201
2.1
68
0.7
P00766P00766['digestion', 'proteolysis']['digestion', 'proteolysis']
Amiloride-sensitive amine oxidase [copper-containing]
736
Amiloride-sensitive amine oxidase [copper-containing]
736
2.1
53
0.9
P19801P19801['amine metabolic process', 'cellular response to azide', 'cellular response to copper ion', 'cellular response to copper ion starvation', 'cellular response to heparin', 'cellular response to histamine', 'putrescine metabolic process', 'response to antibiotic']['amine metabolic process', 'cellular response to azide', 'cellular response to copper ion', 'cellular response to copper ion starvation', 'cellular response to heparin', 'cellular response to histamine', 'putrescine metabolic process', 'response to antibiotic']
Collagen alpha-1(I) chain
1282
Collagen alpha-1(I) chain
1265
2.1
58
0.82
P02452P02452['blood vessel development', 'bone trabecula formation', 'cartilage development involved in endochondral bone morphogenesis', 'cellular response to amino acid stimulus', 'cellular response to epidermal growth factor stimulus', 'cellular response to fibroblast growth factor stimulus', 'cellular response to fluoride', 'cellular response to mechanical stimulus', 'cellular response to retinoic acid', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to vitamin E', 'collagen biosynthetic process', 'collagen fibril organization', 'collagen-activated tyrosine kinase receptor signaling pathway', 'embryonic skeletal system development', 'endochondral ossification', 'extracellular matrix organization', 'face morphogenesis', 'intramembranous ossification', 'negative regulation of cell-substrate adhesion', 'ossification', 'osteoblast differentiation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cell migration', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of transcription, DNA-templated', 'protein localization to nucleus', 'protein transport', 'response to cAMP', 'response to corticosteroid', 'response to estradiol', 'response to hydrogen peroxide', 'response to hyperoxia', 'response to mechanical stimulus', 'response to peptide hormone', 'response to xenobiotic stimulus', 'sensory perception of sound', 'skeletal system development', 'skin development', 'skin morphogenesis', 'tooth eruption', 'tooth mineralization', 'visual perception', 'wound healing']['blood vessel development', 'bone trabecula formation', 'cartilage development involved in endochondral bone morphogenesis', 'cellular response to amino acid stimulus', 'cellular response to epidermal growth factor stimulus', 'cellular response to fibroblast growth factor stimulus', 'cellular response to fluoride', 'cellular response to mechanical stimulus', 'cellular response to retinoic acid', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to vitamin E', 'collagen biosynthetic process', 'collagen fibril organization', 'collagen-activated tyrosine kinase receptor signaling pathway', 'embryonic skeletal system development', 'endochondral ossification', 'extracellular matrix organization', 'face morphogenesis', 'intramembranous ossification', 'negative regulation of cell-substrate adhesion', 'ossification', 'osteoblast differentiation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cell migration', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of transcription, DNA-templated', 'protein localization to nucleus', 'protein transport', 'response to cAMP', 'response to corticosteroid', 'response to estradiol', 'response to hydrogen peroxide', 'response to hyperoxia', 'response to mechanical stimulus', 'response to peptide hormone', 'response to xenobiotic stimulus', 'sensory perception of sound', 'skeletal system development', 'skin development', 'skin morphogenesis', 'tooth eruption', 'tooth mineralization', 'visual perception', 'wound healing']
Ganglioside-induced differentiation-associated protein 1
88
Ganglioside-induced differentiation-associated protein 1
88
3.0
70
0.47
Q8TB36Q8TB36['cellular response to vitamin D', 'glutathione metabolic process', 'mitochondrial fission', 'mitochondrial fusion', 'protein targeting to mitochondrion', 'response to retinoic acid']['cellular response to vitamin D', 'glutathione metabolic process', 'mitochondrial fission', 'mitochondrial fusion', 'protein targeting to mitochondrion', 'response to retinoic acid']
Myeloperoxidase
319
Myeloperoxidase
319
2.7
64
0.59
P05164P05164['aging', 'defense response', 'defense response to bacterium', 'defense response to fungus', 'hydrogen peroxide catabolic process', 'hypochlorous acid biosynthetic process', 'low-density lipoprotein particle remodeling', 'negative regulation of apoptotic process', 'removal of superoxide radicals', 'respiratory burst involved in defense response', 'response to food', 'response to gold nanoparticle', 'response to lipopolysaccharide', 'response to mechanical stimulus', 'response to oxidative stress', 'response to yeast']['aging', 'defense response', 'defense response to bacterium', 'defense response to fungus', 'hydrogen peroxide catabolic process', 'hypochlorous acid biosynthetic process', 'low-density lipoprotein particle remodeling', 'negative regulation of apoptotic process', 'removal of superoxide radicals', 'respiratory burst involved in defense response', 'response to food', 'response to gold nanoparticle', 'response to lipopolysaccharide', 'response to mechanical stimulus', 'response to oxidative stress', 'response to yeast']
Retinoic acid receptor RXR-alpha
269
Retinoic acid receptor RXR-alpha
269
2.7
53
0.69
P19793P19793['anatomical structure development', 'cell differentiation', 'hormone-mediated signaling pathway', 'mRNA transcription by RNA polymerase II', 'negative regulation of transcription by RNA polymerase II', 'peroxisome proliferator activated receptor signaling pathway', 'positive regulation of bone mineralization', 'positive regulation of cholesterol efflux', 'positive regulation of thyroid hormone mediated signaling pathway', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of transporter activity', 'positive regulation of vitamin D receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'response to retinoic acid', 'retinoic acid receptor signaling pathway']['anatomical structure development', 'cell differentiation', 'hormone-mediated signaling pathway', 'mRNA transcription by RNA polymerase II', 'negative regulation of transcription by RNA polymerase II', 'peroxisome proliferator activated receptor signaling pathway', 'positive regulation of bone mineralization', 'positive regulation of cholesterol efflux', 'positive regulation of thyroid hormone mediated signaling pathway', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of transporter activity', 'positive regulation of vitamin D receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'response to retinoic acid', 'retinoic acid receptor signaling pathway']
Regulator of G-protein signaling 3
315
Regulator of G-protein signaling 3
315
2.7
77
0.48
P49796P49796['G protein-coupled receptor signaling pathway', 'negative regulation of signal transduction', 'regulation of G protein-coupled receptor signaling pathway', 'signal transduction']['G protein-coupled receptor signaling pathway', 'negative regulation of signal transduction', 'regulation of G protein-coupled receptor signaling pathway', 'signal transduction']
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
235
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
235
2.7
51
0.72
Q09324Q09324['cell adhesion molecule production', 'glycoprotein biosynthetic process', 'kidney morphogenesis', 'leukocyte tethering or rolling', 'O-glycan processing, core 2', 'positive regulation of leukocyte tethering or rolling', 'response to insulin', 'tissue morphogenesis']['cell adhesion molecule production', 'glycoprotein biosynthetic process', 'kidney morphogenesis', 'leukocyte tethering or rolling', 'O-glycan processing, core 2', 'positive regulation of leukocyte tethering or rolling', 'response to insulin', 'tissue morphogenesis']
Tumor necrosis factor ligand superfamily member 10
230
Tumor necrosis factor ligand superfamily member 10
230
2.7
82
0.45
P50591P50591['apoptotic process', 'cell-cell signaling', 'immune response', 'male gonad development', 'positive regulation of apoptotic process', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of release of cytochrome c from mitochondria', 'response to insulin', 'signal transduction']['apoptotic process', 'cell-cell signaling', 'immune response', 'male gonad development', 'positive regulation of apoptotic process', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of release of cytochrome c from mitochondria', 'response to insulin', 'signal transduction']
Retinoblastoma-associated protein
438
Retinoblastoma-associated protein
438
2.7
60
0.62
P06400P06400['aortic valve morphogenesis', 'cell differentiation', 'cell division', 'cell morphogenesis involved in neuron differentiation', 'cellular response to insulin stimulus', 'cellular response to xenobiotic stimulus', 'chondrocyte differentiation', 'chromatin remodeling', 'digestive tract development', 'enucleate erythrocyte differentiation', 'epithelial cell proliferation', 'glial cell apoptotic process', 'glial cell proliferation', 'hepatocyte apoptotic process', 'heterochromatin assembly', 'maintenance of mitotic sister chromatid cohesion', 'myoblast differentiation', 'negative regulation of apoptotic signaling pathway', 'negative regulation of cell cycle', 'negative regulation of cell growth', 'negative regulation of cold-induced thermogenesis', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of epithelial cell proliferation', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of gene expression', 'negative regulation of glial cell proliferation', 'negative regulation of hepatocyte apoptotic process', 'negative regulation of inflammatory response', 'negative regulation of myofibroblast differentiation', 'negative regulation of protein kinase activity', 'negative regulation of protein serine/threonine kinase activity', 'negative regulation of smoothened signaling pathway', 'negative regulation of tau-protein kinase activity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription involved in G1/S transition of mitotic cell cycle', 'negative regulation of transcription, DNA-templated', 'neuron apoptotic process', 'neuron maturation', 'neuron projection development', 'positive regulation of collagen fibril organization', 'positive regulation of extracellular matrix organization', 'positive regulation of macrophage differentiation', 'positive regulation of mitotic metaphase/anaphase transition', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'protein localization to chromosome, centromeric region', 'Ras protein signal transduction', 'regulation of cell cycle', 'regulation of centromere complex assembly', 'regulation of cohesin loading', 'regulation of lipid kinase activity', 'regulation of mitotic cell cycle', 'regulation of transcription, DNA-templated', 'sister chromatid biorientation', 'skeletal muscle cell differentiation', 'smoothened signaling pathway', 'spermatogenesis', 'striated muscle cell differentiation', 'tissue homeostasis', 'transcription by RNA polymerase II']['aortic valve morphogenesis', 'cell differentiation', 'cell division', 'cell morphogenesis involved in neuron differentiation', 'cellular response to insulin stimulus', 'cellular response to xenobiotic stimulus', 'chondrocyte differentiation', 'chromatin remodeling', 'digestive tract development', 'enucleate erythrocyte differentiation', 'epithelial cell proliferation', 'glial cell apoptotic process', 'glial cell proliferation', 'hepatocyte apoptotic process', 'heterochromatin assembly', 'maintenance of mitotic sister chromatid cohesion', 'myoblast differentiation', 'negative regulation of apoptotic signaling pathway', 'negative regulation of cell cycle', 'negative regulation of cell growth', 'negative regulation of cold-induced thermogenesis', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of epithelial cell proliferation', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of gene expression', 'negative regulation of glial cell proliferation', 'negative regulation of hepatocyte apoptotic process', 'negative regulation of inflammatory response', 'negative regulation of myofibroblast differentiation', 'negative regulation of protein kinase activity', 'negative regulation of protein serine/threonine kinase activity', 'negative regulation of smoothened signaling pathway', 'negative regulation of tau-protein kinase activity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription involved in G1/S transition of mitotic cell cycle', 'negative regulation of transcription, DNA-templated', 'neuron apoptotic process', 'neuron maturation', 'neuron projection development', 'positive regulation of collagen fibril organization', 'positive regulation of extracellular matrix organization', 'positive regulation of macrophage differentiation', 'positive regulation of mitotic metaphase/anaphase transition', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'protein localization to chromosome, centromeric region', 'Ras protein signal transduction', 'regulation of cell cycle', 'regulation of centromere complex assembly', 'regulation of cohesin loading', 'regulation of lipid kinase activity', 'regulation of mitotic cell cycle', 'regulation of transcription, DNA-templated', 'sister chromatid biorientation', 'skeletal muscle cell differentiation', 'smoothened signaling pathway', 'spermatogenesis', 'striated muscle cell differentiation', 'tissue homeostasis', 'transcription by RNA polymerase II']
Phenylethanolamine N-methyltransferase
48
Phenylethanolamine N-methyltransferase
139
2.7
65
0.57
P11086P11086['catecholamine biosynthetic process', 'epinephrine biosynthetic process', 'methylation']['catecholamine biosynthetic process', 'epinephrine biosynthetic process', 'methylation']
ETS translocation variant 1
416
ETS translocation variant 1
416
2.7
61
0.61
P50549P50549['axon guidance', 'cell differentiation', 'mechanosensory behavior', 'muscle organ development', 'peripheral nervous system neuron development', 'positive regulation of transcription by RNA polymerase II', 'regulation of transcription by RNA polymerase II', 'transcription by RNA polymerase II']['axon guidance', 'cell differentiation', 'mechanosensory behavior', 'muscle organ development', 'peripheral nervous system neuron development', 'positive regulation of transcription by RNA polymerase II', 'regulation of transcription by RNA polymerase II', 'transcription by RNA polymerase II']
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
166
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
166
2.6
92
0.41
P13995P13995['folic acid metabolic process', 'tetrahydrofolate interconversion', 'tetrahydrofolate metabolic process']['folic acid metabolic process', 'tetrahydrofolate interconversion', 'tetrahydrofolate metabolic process']
Poly [ADP-ribose] polymerase 1
845
Poly [ADP-ribose] polymerase 1
845
2.6
66
0.57
P09874P09874['apoptotic process', 'ATP generation from poly-ADP-D-ribose', 'cellular response to amyloid-beta', 'cellular response to DNA damage stimulus', 'cellular response to insulin stimulus', 'cellular response to oxidative stress', 'cellular response to UV', 'cellular response to zinc ion', 'DNA ADP-ribosylation', 'DNA repair', 'double-strand break repair', 'macrophage differentiation', 'mitochondrial DNA metabolic process', 'mitochondrial DNA repair', 'mitochondrion organization', 'negative regulation of ATP biosynthetic process', 'negative regulation of telomere maintenance via telomere lengthening', 'negative regulation of transcription by RNA polymerase II', 'peptidyl-glutamic acid poly-ADP-ribosylation', 'peptidyl-serine ADP-ribosylation', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of double-strand break repair via homologous recombination', 'positive regulation of intracellular estrogen receptor signaling pathway', 'positive regulation of mitochondrial depolarization', 'positive regulation of myofibroblast differentiation', 'positive regulation of neuron death', 'positive regulation of protein localization to nucleus', 'positive regulation of single strand break repair', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'protein ADP-ribosylation', 'protein auto-ADP-ribosylation', 'protein autoprocessing', 'protein modification process', 'protein poly-ADP-ribosylation', 'regulation of catalytic activity', 'regulation of DNA methylation', 'regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'regulation of protein localization', 'regulation of SMAD protein complex assembly', 'response to aldosterone', 'response to gamma radiation', 'signal transduction involved in regulation of gene expression', 'telomere maintenance', 'transcription by RNA polymerase II', 'transforming growth factor beta receptor signaling pathway']['apoptotic process', 'ATP generation from poly-ADP-D-ribose', 'cellular response to amyloid-beta', 'cellular response to DNA damage stimulus', 'cellular response to insulin stimulus', 'cellular response to oxidative stress', 'cellular response to UV', 'cellular response to zinc ion', 'DNA ADP-ribosylation', 'DNA repair', 'double-strand break repair', 'macrophage differentiation', 'mitochondrial DNA metabolic process', 'mitochondrial DNA repair', 'mitochondrion organization', 'negative regulation of ATP biosynthetic process', 'negative regulation of telomere maintenance via telomere lengthening', 'negative regulation of transcription by RNA polymerase II', 'peptidyl-glutamic acid poly-ADP-ribosylation', 'peptidyl-serine ADP-ribosylation', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of double-strand break repair via homologous recombination', 'positive regulation of intracellular estrogen receptor signaling pathway', 'positive regulation of mitochondrial depolarization', 'positive regulation of myofibroblast differentiation', 'positive regulation of neuron death', 'positive regulation of protein localization to nucleus', 'positive regulation of single strand break repair', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'protein ADP-ribosylation', 'protein auto-ADP-ribosylation', 'protein autoprocessing', 'protein modification process', 'protein poly-ADP-ribosylation', 'regulation of catalytic activity', 'regulation of DNA methylation', 'regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'regulation of protein localization', 'regulation of SMAD protein complex assembly', 'response to aldosterone', 'response to gamma radiation', 'signal transduction involved in regulation of gene expression', 'telomere maintenance', 'transcription by RNA polymerase II', 'transforming growth factor beta receptor signaling pathway']
Protein mono-ADP-ribosyltransferase PARP14
1618
Protein mono-ADP-ribosyltransferase PARP14
1618
2.6
63
0.61
Q460N5Q460N5['innate immune response', 'negative regulation of gene expression', 'negative regulation of interferon-gamma-mediated signaling pathway', 'negative regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of interleukin-4-mediated signaling pathway', 'positive regulation of tyrosine phosphorylation of STAT protein', 'protein ADP-ribosylation', 'protein mono-ADP-ribosylation', 'protein poly-ADP-ribosylation']['innate immune response', 'negative regulation of gene expression', 'negative regulation of interferon-gamma-mediated signaling pathway', 'negative regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of interleukin-4-mediated signaling pathway', 'positive regulation of tyrosine phosphorylation of STAT protein', 'protein ADP-ribosylation', 'protein mono-ADP-ribosylation', 'protein poly-ADP-ribosylation']
Complement C3
559
Complement C3
816
2.6
76
0.51
P01024P01024['amyloid-beta clearance', 'cell surface receptor signaling pathway involved in cell-cell signaling', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'complement-mediated synapse pruning', 'fatty acid metabolic process', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'neuron remodeling', 'opsonization', 'oviduct epithelium development', 'positive regulation of activation of membrane attack complex', 'positive regulation of angiogenesis', 'positive regulation of apoptotic cell clearance', 'positive regulation of apoptotic process in another organism', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of glucose transmembrane transport', 'positive regulation of immune response', 'positive regulation of lipid storage', 'positive regulation of opsonization', 'positive regulation of phagocytosis', 'positive regulation of phagocytosis, engulfment', 'positive regulation of protein phosphorylation', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of type IIa hypersensitivity', 'positive regulation of vascular endothelial growth factor production', 'proteolysis', 'regulation of complement activation', 'regulation of complement activation, alternative pathway', 'regulation of triglyceride biosynthetic process', 'response to bacterium', 'signal transduction', 'vertebrate eye-specific patterning']['amyloid-beta clearance', 'cell surface receptor signaling pathway involved in cell-cell signaling', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'complement-mediated synapse pruning', 'fatty acid metabolic process', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'neuron remodeling', 'opsonization', 'oviduct epithelium development', 'positive regulation of activation of membrane attack complex', 'positive regulation of angiogenesis', 'positive regulation of apoptotic cell clearance', 'positive regulation of apoptotic process in another organism', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of glucose transmembrane transport', 'positive regulation of immune response', 'positive regulation of lipid storage', 'positive regulation of opsonization', 'positive regulation of phagocytosis', 'positive regulation of phagocytosis, engulfment', 'positive regulation of protein phosphorylation', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of type IIa hypersensitivity', 'positive regulation of vascular endothelial growth factor production', 'proteolysis', 'regulation of complement activation', 'regulation of complement activation, alternative pathway', 'regulation of triglyceride biosynthetic process', 'response to bacterium', 'signal transduction', 'vertebrate eye-specific patterning']
Cyclin-A2
327
Cyclin-A2
327
2.6
74
0.52
P20248P20248['animal organ regeneration', 'cell cycle G1/S phase transition', 'cell division', 'cellular response to cocaine', 'cellular response to estradiol stimulus', 'cellular response to hypoxia', 'cellular response to insulin-like growth factor stimulus', 'cellular response to leptin stimulus', 'cellular response to luteinizing hormone stimulus', 'cellular response to nitric oxide', 'cellular response to platelet-derived growth factor stimulus', 'cochlea development', 'G2/M transition of mitotic cell cycle', 'histone phosphorylation', 'mitotic cell cycle phase transition', 'positive regulation of fibroblast proliferation', 'positive regulation of transcription, DNA-templated', 'Ras protein signal transduction', 'regulation of cyclin-dependent protein serine/threonine kinase activity', 'regulation of DNA replication', 'response to glucagon', 'transcription, DNA-templated']['animal organ regeneration', 'cell cycle G1/S phase transition', 'cell division', 'cellular response to cocaine', 'cellular response to estradiol stimulus', 'cellular response to hypoxia', 'cellular response to insulin-like growth factor stimulus', 'cellular response to leptin stimulus', 'cellular response to luteinizing hormone stimulus', 'cellular response to nitric oxide', 'cellular response to platelet-derived growth factor stimulus', 'cochlea development', 'G2/M transition of mitotic cell cycle', 'histone phosphorylation', 'mitotic cell cycle phase transition', 'positive regulation of fibroblast proliferation', 'positive regulation of transcription, DNA-templated', 'Ras protein signal transduction', 'regulation of cyclin-dependent protein serine/threonine kinase activity', 'regulation of DNA replication', 'response to glucagon', 'transcription, DNA-templated']
Histone-lysine N-methyltransferase 2A
1575
Histone-lysine N-methyltransferase 2A
1575
2.7
61
0.61
Q03164Q03164['anterior/posterior pattern specification', 'apoptotic process', 'chromatin organization', 'circadian regulation of gene expression', 'definitive hemopoiesis', 'DNA methylation', 'embryonic hemopoiesis', 'exploration behavior', 'fibroblast proliferation', 'histone H3-K4 dimethylation', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'histone H3-K4 trimethylation', 'histone H4-K16 acetylation', 'homeostasis of number of cells within a tissue', 'membrane depolarization', 'negative regulation of DNA methylation', 'negative regulation of fibroblast proliferation', 'peptidyl-lysine monomethylation', 'positive regulation of histone H3-K4 methylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of transporter activity', 'post-embryonic development', 'protein-containing complex assembly', 'regulation of histone H3-K14 acetylation', 'regulation of histone H3-K27 acetylation', 'regulation of histone H3-K9 acetylation', 'regulation of short-term neuronal synaptic plasticity', 'response to potassium ion', 'spleen development', 'visual learning']['anterior/posterior pattern specification', 'apoptotic process', 'chromatin organization', 'circadian regulation of gene expression', 'definitive hemopoiesis', 'DNA methylation', 'embryonic hemopoiesis', 'exploration behavior', 'fibroblast proliferation', 'histone H3-K4 dimethylation', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'histone H3-K4 trimethylation', 'histone H4-K16 acetylation', 'homeostasis of number of cells within a tissue', 'membrane depolarization', 'negative regulation of DNA methylation', 'negative regulation of fibroblast proliferation', 'peptidyl-lysine monomethylation', 'positive regulation of histone H3-K4 methylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of transporter activity', 'post-embryonic development', 'protein-containing complex assembly', 'regulation of histone H3-K14 acetylation', 'regulation of histone H3-K27 acetylation', 'regulation of histone H3-K9 acetylation', 'regulation of short-term neuronal synaptic plasticity', 'response to potassium ion', 'spleen development', 'visual learning']
Seminal ribonuclease
57
Seminal ribonuclease
58
2.1
62
0.78
P00669P00669['defense response to Gram-positive bacterium', 'RNA phosphodiester bond hydrolysis']['defense response to Gram-positive bacterium', 'RNA phosphodiester bond hydrolysis']
Allograft inflammatory factor 1-like
35
Allograft inflammatory factor 1-like
35
2.1
52
0.94
Q9BQI0Q9BQI0['actin filament bundle assembly', 'ruffle assembly']['actin filament bundle assembly', 'ruffle assembly']
Insulin
104
Insulin
43
2.1
60
0.81
P01317P01317['estradiol secretion', 'feeding behavior', 'glucose import in response to insulin stimulus', 'glucose metabolic process', 'negative regulation of apoptotic process', 'negative regulation of appetite', 'negative regulation of lactation', 'negative regulation of lipid catabolic process', 'positive regulation of blood circulation', 'positive regulation of cell maturation', 'positive regulation of gene expression', 'positive regulation of insulin secretion', 'positive regulation of lactation', 'positive regulation of mammary gland epithelial cell proliferation', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Rho protein signal transduction', 'protein secretion', 'response to butyrate', 'response to food', 'response to glucose', 'response to growth hormone', 'response to heat', 'response to L-arginine', 'response to nutrient levels']['estradiol secretion', 'feeding behavior', 'glucose import in response to insulin stimulus', 'glucose metabolic process', 'negative regulation of apoptotic process', 'negative regulation of appetite', 'negative regulation of lactation', 'negative regulation of lipid catabolic process', 'positive regulation of blood circulation', 'positive regulation of cell maturation', 'positive regulation of gene expression', 'positive regulation of insulin secretion', 'positive regulation of lactation', 'positive regulation of mammary gland epithelial cell proliferation', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Rho protein signal transduction', 'protein secretion', 'response to butyrate', 'response to food', 'response to glucose', 'response to growth hormone', 'response to heat', 'response to L-arginine', 'response to nutrient levels']
Angiotensinogen
340
Angiotensinogen
340
2.6
65
0.6
P01015P01015['activation of NF-kappaB-inducing kinase activity', 'activation of phospholipase C activity', 'aging', 'aldosterone secretion', 'angiotensin-activated signaling pathway', 'angiotensin-mediated drinking behavior', 'angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure', 'artery smooth muscle contraction', 'associative learning', 'astrocyte activation', 'blood vessel development', 'brain renin-angiotensin system', 'branching involved in ureteric bud morphogenesis', 'cell growth involved in cardiac muscle cell development', 'cell surface receptor signaling pathway', 'cell-matrix adhesion', 'cellular response to angiotensin', 'cellular response to mechanical stimulus', 'cellular sodium ion homeostasis', 'drinking behavior', 'ERK1 and ERK2 cascade', 'establishment of blood-nerve barrier', 'extracellular matrix organization', 'female pregnancy', 'fibroblast proliferation', 'G protein-coupled receptor signaling pathway', 'hormone metabolic process', 'kidney development', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of endopeptidase activity', 'negative regulation of MAP kinase activity', 'negative regulation of neuron apoptotic process', 'negative regulation of neurotrophin TRK receptor signaling pathway', 'negative regulation of tissue remodeling', 'operant conditioning', 'ovarian follicle rupture', 'peristalsis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of blood pressure', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of catalytic activity', 'positive regulation of cell population proliferation', 'positive regulation of cholesterol esterification', 'positive regulation of CoA-transferase activity', 'positive regulation of cytokine production', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of endothelial cell migration', 'positive regulation of epidermal growth factor receptor signaling pathway', 'positive regulation of extracellular matrix constituent secretion', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of fatty acid biosynthetic process', 'positive regulation of fibroblast proliferation', 'positive regulation of gap junction assembly', 'positive regulation of gene expression', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of L-arginine import across plasma membrane', 'positive regulation of L-lysine import across plasma membrane', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of MAPK cascade', 'positive regulation of multicellular organism growth', 'positive regulation of neuron projection development', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of organ growth', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase C activity', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of renal sodium excretion', 'positive regulation of superoxide anion generation', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular associated smooth muscle cell migration', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein import into nucleus', 'regulation of apoptotic process', 'regulation of blood pressure', 'regulation of calcium ion transport', 'regulation of cardiac conduction', 'regulation of extracellular matrix assembly', 'regulation of gene expression', 'regulation of heart rate', 'regulation of inflammatory response', 'regulation of long-term neuronal synaptic plasticity', 'regulation of norepinephrine secretion', 'regulation of renal output by angiotensin', 'regulation of renal sodium excretion', 'regulation of systemic arterial blood pressure by circulatory renin-angiotensin', 'regulation of transmission of nerve impulse', 'renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure', 'renal system process', 'renin-angiotensin regulation of aldosterone production', 'response to cold', 'response to estradiol', 'response to muscle activity involved in regulation of muscle adaptation', 'response to salt stress', 'smooth muscle cell differentiation', 'smooth muscle cell proliferation', 'stress-activated MAPK cascade', 'uterine smooth muscle contraction', 'vasoconstriction', 'vasodilation', 'vasopressin secretion']['activation of NF-kappaB-inducing kinase activity', 'activation of phospholipase C activity', 'aging', 'aldosterone secretion', 'angiotensin-activated signaling pathway', 'angiotensin-mediated drinking behavior', 'angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure', 'artery smooth muscle contraction', 'associative learning', 'astrocyte activation', 'blood vessel development', 'brain renin-angiotensin system', 'branching involved in ureteric bud morphogenesis', 'cell growth involved in cardiac muscle cell development', 'cell surface receptor signaling pathway', 'cell-matrix adhesion', 'cellular response to angiotensin', 'cellular response to mechanical stimulus', 'cellular sodium ion homeostasis', 'drinking behavior', 'ERK1 and ERK2 cascade', 'establishment of blood-nerve barrier', 'extracellular matrix organization', 'female pregnancy', 'fibroblast proliferation', 'G protein-coupled receptor signaling pathway', 'hormone metabolic process', 'kidney development', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of endopeptidase activity', 'negative regulation of MAP kinase activity', 'negative regulation of neuron apoptotic process', 'negative regulation of neurotrophin TRK receptor signaling pathway', 'negative regulation of tissue remodeling', 'operant conditioning', 'ovarian follicle rupture', 'peristalsis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of blood pressure', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of catalytic activity', 'positive regulation of cell population proliferation', 'positive regulation of cholesterol esterification', 'positive regulation of CoA-transferase activity', 'positive regulation of cytokine production', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of endothelial cell migration', 'positive regulation of epidermal growth factor receptor signaling pathway', 'positive regulation of extracellular matrix constituent secretion', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of fatty acid biosynthetic process', 'positive regulation of fibroblast proliferation', 'positive regulation of gap junction assembly', 'positive regulation of gene expression', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of L-arginine import across plasma membrane', 'positive regulation of L-lysine import across plasma membrane', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of MAPK cascade', 'positive regulation of multicellular organism growth', 'positive regulation of neuron projection development', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of organ growth', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase C activity', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of renal sodium excretion', 'positive regulation of superoxide anion generation', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular associated smooth muscle cell migration', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein import into nucleus', 'regulation of apoptotic process', 'regulation of blood pressure', 'regulation of calcium ion transport', 'regulation of cardiac conduction', 'regulation of extracellular matrix assembly', 'regulation of gene expression', 'regulation of heart rate', 'regulation of inflammatory response', 'regulation of long-term neuronal synaptic plasticity', 'regulation of norepinephrine secretion', 'regulation of renal output by angiotensin', 'regulation of renal sodium excretion', 'regulation of systemic arterial blood pressure by circulatory renin-angiotensin', 'regulation of transmission of nerve impulse', 'renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure', 'renal system process', 'renin-angiotensin regulation of aldosterone production', 'response to cold', 'response to estradiol', 'response to muscle activity involved in regulation of muscle adaptation', 'response to salt stress', 'smooth muscle cell differentiation', 'smooth muscle cell proliferation', 'stress-activated MAPK cascade', 'uterine smooth muscle contraction', 'vasoconstriction', 'vasodilation', 'vasopressin secretion']
Antiviral innate immune response receptor RIG-I
829
Antiviral innate immune response receptor RIG-I
829
2.7
65
0.56
O95786O95786['antiviral innate immune response', 'cellular response to exogenous dsRNA', 'cytoplasmic pattern recognition receptor signaling pathway in response to virus', 'defense response to virus', 'detection of virus', 'gene expression', 'innate immune response', 'positive regulation of defense response to virus by host', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of gene expression', 'positive regulation of granulocyte macrophage colony-stimulating factor production', 'positive regulation of interferon-alpha production', 'positive regulation of interferon-beta production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of myeloid dendritic cell cytokine production', 'positive regulation of response to cytokine stimulus', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'regulation of cell migration', 'regulation of type III interferon production', 'response to exogenous dsRNA', 'response to virus', 'RIG-I signaling pathway']['antiviral innate immune response', 'cellular response to exogenous dsRNA', 'cytoplasmic pattern recognition receptor signaling pathway in response to virus', 'defense response to virus', 'detection of virus', 'gene expression', 'innate immune response', 'positive regulation of defense response to virus by host', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of gene expression', 'positive regulation of granulocyte macrophage colony-stimulating factor production', 'positive regulation of interferon-alpha production', 'positive regulation of interferon-beta production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of myeloid dendritic cell cytokine production', 'positive regulation of response to cytokine stimulus', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'regulation of cell migration', 'regulation of type III interferon production', 'response to exogenous dsRNA', 'response to virus', 'RIG-I signaling pathway']
Filamin-C
712
Filamin-C
712
3.0
60
0.55
Q14315Q14315['sarcomere organization']['sarcomere organization']
Fibroblast growth factor receptor 2
491
Fibroblast growth factor receptor 2
491
2.9
40
0.86
P21802P21802['angiogenesis', 'animal organ morphogenesis', 'apoptotic process', 'axonogenesis', 'bone development', 'bone mineralization', 'bone morphogenesis', 'branch elongation involved in salivary gland morphogenesis', 'branching involved in labyrinthine layer morphogenesis', 'branching involved in prostate gland morphogenesis', 'branching involved in salivary gland morphogenesis', 'branching morphogenesis of a nerve', 'bud elongation involved in lung branching', 'cell fate commitment', 'cell-cell signaling', 'cellular response to retinoic acid', 'cellular response to transforming growth factor beta stimulus', 'digestive tract development', 'embryonic cranial skeleton morphogenesis', 'embryonic digestive tract morphogenesis', 'embryonic organ development', 'embryonic organ morphogenesis', 'embryonic pattern specification', 'endochondral bone growth', 'epidermis morphogenesis', 'epithelial cell differentiation', 'epithelial cell proliferation involved in salivary gland morphogenesis', 'epithelial to mesenchymal transition', 'fibroblast growth factor receptor signaling pathway', 'fibroblast growth factor receptor signaling pathway involved in hemopoiesis', 'fibroblast growth factor receptor signaling pathway involved in mammary gland specification', 'fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell', 'fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development', 'fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow', 'gland morphogenesis', 'hair follicle morphogenesis', 'in utero embryonic development', 'inner ear morphogenesis', 'lacrimal gland development', 'lateral sprouting from an epithelium', 'limb bud formation', 'lung alveolus development', 'lung development', 'lung lobe morphogenesis', 'lung-associated mesenchyme development', 'mammary gland bud formation', 'membranous septum morphogenesis', 'mesenchymal cell differentiation', 'mesenchymal cell differentiation involved in lung development', 'mesenchymal cell proliferation involved in lung development', 'mesodermal cell differentiation', 'midbrain development', 'morphogenesis of embryonic epithelium', 'negative regulation of keratinocyte proliferation', 'negative regulation of transcription by RNA polymerase II', 'odontogenesis', 'orbitofrontal cortex development', 'organ growth', 'otic vesicle formation', 'outflow tract septum morphogenesis', 'peptidyl-tyrosine phosphorylation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cell cycle', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial cell proliferation involved in lung morphogenesis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mesenchymal cell proliferation', 'positive regulation of phospholipase activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of Wnt signaling pathway', 'post-embryonic development', 'prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis', 'prostate epithelial cord elongation', 'prostate gland morphogenesis', 'protein autophosphorylation', 'pyramidal neuron development', 'regulation of ERK1 and ERK2 cascade', 'regulation of morphogenesis of a branching structure', 'regulation of osteoblast differentiation', 'regulation of osteoblast proliferation', 'regulation of smooth muscle cell differentiation', 'regulation of smoothened signaling pathway', 'reproductive structure development', 'response to ethanol', 'response to lipopolysaccharide', 'skeletal system morphogenesis', 'squamous basal epithelial stem cell differentiation involved in prostate gland acinus development', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'ureteric bud development', 'ventricular cardiac muscle tissue morphogenesis', 'ventricular zone neuroblast division', 'wound healing']['angiogenesis', 'animal organ morphogenesis', 'apoptotic process', 'axonogenesis', 'bone development', 'bone mineralization', 'bone morphogenesis', 'branch elongation involved in salivary gland morphogenesis', 'branching involved in labyrinthine layer morphogenesis', 'branching involved in prostate gland morphogenesis', 'branching involved in salivary gland morphogenesis', 'branching morphogenesis of a nerve', 'bud elongation involved in lung branching', 'cell fate commitment', 'cell-cell signaling', 'cellular response to retinoic acid', 'cellular response to transforming growth factor beta stimulus', 'digestive tract development', 'embryonic cranial skeleton morphogenesis', 'embryonic digestive tract morphogenesis', 'embryonic organ development', 'embryonic organ morphogenesis', 'embryonic pattern specification', 'endochondral bone growth', 'epidermis morphogenesis', 'epithelial cell differentiation', 'epithelial cell proliferation involved in salivary gland morphogenesis', 'epithelial to mesenchymal transition', 'fibroblast growth factor receptor signaling pathway', 'fibroblast growth factor receptor signaling pathway involved in hemopoiesis', 'fibroblast growth factor receptor signaling pathway involved in mammary gland specification', 'fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell', 'fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development', 'fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow', 'gland morphogenesis', 'hair follicle morphogenesis', 'in utero embryonic development', 'inner ear morphogenesis', 'lacrimal gland development', 'lateral sprouting from an epithelium', 'limb bud formation', 'lung alveolus development', 'lung development', 'lung lobe morphogenesis', 'lung-associated mesenchyme development', 'mammary gland bud formation', 'membranous septum morphogenesis', 'mesenchymal cell differentiation', 'mesenchymal cell differentiation involved in lung development', 'mesenchymal cell proliferation involved in lung development', 'mesodermal cell differentiation', 'midbrain development', 'morphogenesis of embryonic epithelium', 'negative regulation of keratinocyte proliferation', 'negative regulation of transcription by RNA polymerase II', 'odontogenesis', 'orbitofrontal cortex development', 'organ growth', 'otic vesicle formation', 'outflow tract septum morphogenesis', 'peptidyl-tyrosine phosphorylation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cell cycle', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial cell proliferation involved in lung morphogenesis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mesenchymal cell proliferation', 'positive regulation of phospholipase activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of Wnt signaling pathway', 'post-embryonic development', 'prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis', 'prostate epithelial cord elongation', 'prostate gland morphogenesis', 'protein autophosphorylation', 'pyramidal neuron development', 'regulation of ERK1 and ERK2 cascade', 'regulation of morphogenesis of a branching structure', 'regulation of osteoblast differentiation', 'regulation of osteoblast proliferation', 'regulation of smooth muscle cell differentiation', 'regulation of smoothened signaling pathway', 'reproductive structure development', 'response to ethanol', 'response to lipopolysaccharide', 'skeletal system morphogenesis', 'squamous basal epithelial stem cell differentiation involved in prostate gland acinus development', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'ureteric bud development', 'ventricular cardiac muscle tissue morphogenesis', 'ventricular zone neuroblast division', 'wound healing']
Complement C3
1010
Complement C3
1010
2.9
94
0.37
P01024P01024['amyloid-beta clearance', 'cell surface receptor signaling pathway involved in cell-cell signaling', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'complement-mediated synapse pruning', 'fatty acid metabolic process', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'neuron remodeling', 'opsonization', 'oviduct epithelium development', 'positive regulation of activation of membrane attack complex', 'positive regulation of angiogenesis', 'positive regulation of apoptotic cell clearance', 'positive regulation of apoptotic process in another organism', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of glucose transmembrane transport', 'positive regulation of immune response', 'positive regulation of lipid storage', 'positive regulation of opsonization', 'positive regulation of phagocytosis', 'positive regulation of phagocytosis, engulfment', 'positive regulation of protein phosphorylation', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of type IIa hypersensitivity', 'positive regulation of vascular endothelial growth factor production', 'proteolysis', 'regulation of complement activation', 'regulation of complement activation, alternative pathway', 'regulation of triglyceride biosynthetic process', 'response to bacterium', 'signal transduction', 'vertebrate eye-specific patterning']['amyloid-beta clearance', 'cell surface receptor signaling pathway involved in cell-cell signaling', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'complement-mediated synapse pruning', 'fatty acid metabolic process', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'neuron remodeling', 'opsonization', 'oviduct epithelium development', 'positive regulation of activation of membrane attack complex', 'positive regulation of angiogenesis', 'positive regulation of apoptotic cell clearance', 'positive regulation of apoptotic process in another organism', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of glucose transmembrane transport', 'positive regulation of immune response', 'positive regulation of lipid storage', 'positive regulation of opsonization', 'positive regulation of phagocytosis', 'positive regulation of phagocytosis, engulfment', 'positive regulation of protein phosphorylation', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of type IIa hypersensitivity', 'positive regulation of vascular endothelial growth factor production', 'proteolysis', 'regulation of complement activation', 'regulation of complement activation, alternative pathway', 'regulation of triglyceride biosynthetic process', 'response to bacterium', 'signal transduction', 'vertebrate eye-specific patterning']
Nuclear receptor subfamily 1 group I member 3
221
Nuclear receptor subfamily 1 group I member 3
221
2.8
71
0.5
O35627O35627['cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'osteoblast differentiation', 'positive regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated']['cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'osteoblast differentiation', 'positive regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated']
Immunoglobulin kappa constant
107
Ig gamma-2A chain C region, membrane-bound form
14
3.0
nan
nan
P01837P01865['adaptive immune response', 'B cell differentiation', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['antibody-dependent cellular cytotoxicity', 'antigen processing and presentation', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'early endosome to late endosome transport', 'endosome to lysosome transport', 'humoral immune response mediated by circulating immunoglobulin', 'immunoglobulin mediated immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of endocytosis', 'positive regulation of immune response', 'positive regulation of phagocytosis', 'positive regulation of type I hypersensitivity', 'positive regulation of type IIa hypersensitivity', 'regulation of proteolysis']
Bifunctional glutamate/proline--tRNA ligase
105
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
205
3.0
58
0.57
P07814Q13155['cellular response to insulin stimulus', 'cellular response to interferon-gamma', 'glutamyl-tRNA aminoacylation', 'negative regulation of translation', 'prolyl-tRNA aminoacylation', 'protein-containing complex assembly', 'regulation of long-chain fatty acid import into cell', 'tRNA aminoacylation for protein translation']['apoptotic process', 'negative regulation of cell population proliferation', 'positive regulation of aminoacyl-tRNA ligase activity', 'positive regulation of neuron death', 'positive regulation of protein ubiquitination', 'protein ubiquitination', 'protein-containing complex assembly', 'translation', 'type II pneumocyte differentiation']
Galectin-1
131
Galectin-1
131
3.1
64
0.5
P11116P11116['apoptotic process', 'cell-cell adhesion', 'myoblast differentiation', 'plasma cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of inflammatory response', 'positive regulation of viral entry into host cell', 'T cell costimulation']['apoptotic process', 'cell-cell adhesion', 'myoblast differentiation', 'plasma cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of inflammatory response', 'positive regulation of viral entry into host cell', 'T cell costimulation']
Talin-1
575
Talin-1
575
3.1
66
0.49
P26039P26039['cell-cell adhesion', 'cell-substrate junction assembly', 'cortical actin cytoskeleton organization', 'integrin activation', 'integrin-mediated signaling pathway']['cell-cell adhesion', 'cell-substrate junction assembly', 'cortical actin cytoskeleton organization', 'integrin activation', 'integrin-mediated signaling pathway']
Fibrinogen alpha chain
184
Fibrinogen gamma chain
161
3.1
78
0.42
P02671Q53Y18['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Fatty acid synthase
856
Fatty acid synthase
856
3.1
72
0.45
A5YV76A5YV76['fatty acid biosynthetic process']['fatty acid biosynthetic process']
Complement C3
873
Complement C3
1513
3.0
76
0.45
P01024P01024['amyloid-beta clearance', 'cell surface receptor signaling pathway involved in cell-cell signaling', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'complement-mediated synapse pruning', 'fatty acid metabolic process', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'neuron remodeling', 'opsonization', 'oviduct epithelium development', 'positive regulation of activation of membrane attack complex', 'positive regulation of angiogenesis', 'positive regulation of apoptotic cell clearance', 'positive regulation of apoptotic process in another organism', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of glucose transmembrane transport', 'positive regulation of immune response', 'positive regulation of lipid storage', 'positive regulation of opsonization', 'positive regulation of phagocytosis', 'positive regulation of phagocytosis, engulfment', 'positive regulation of protein phosphorylation', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of type IIa hypersensitivity', 'positive regulation of vascular endothelial growth factor production', 'proteolysis', 'regulation of complement activation', 'regulation of complement activation, alternative pathway', 'regulation of triglyceride biosynthetic process', 'response to bacterium', 'signal transduction', 'vertebrate eye-specific patterning']['amyloid-beta clearance', 'cell surface receptor signaling pathway involved in cell-cell signaling', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'complement-mediated synapse pruning', 'fatty acid metabolic process', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'neuron remodeling', 'opsonization', 'oviduct epithelium development', 'positive regulation of activation of membrane attack complex', 'positive regulation of angiogenesis', 'positive regulation of apoptotic cell clearance', 'positive regulation of apoptotic process in another organism', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of glucose transmembrane transport', 'positive regulation of immune response', 'positive regulation of lipid storage', 'positive regulation of opsonization', 'positive regulation of phagocytosis', 'positive regulation of phagocytosis, engulfment', 'positive regulation of protein phosphorylation', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of type IIa hypersensitivity', 'positive regulation of vascular endothelial growth factor production', 'proteolysis', 'regulation of complement activation', 'regulation of complement activation, alternative pathway', 'regulation of triglyceride biosynthetic process', 'response to bacterium', 'signal transduction', 'vertebrate eye-specific patterning']
Indoleamine 2,3-dioxygenase 1
308
Indoleamine 2,3-dioxygenase 1
308
2.7
68
0.54
P14902P14902["'de novo' NAD biosynthetic process from tryptophan", 'female pregnancy', 'inflammatory response', 'kynurenic acid biosynthetic process', 'multicellular organismal response to stress', 'negative regulation of interleukin-10 production', 'negative regulation of T cell apoptotic process', 'negative regulation of T cell proliferation', 'positive regulation of chronic inflammatory response', 'positive regulation of interleukin-12 production', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell tolerance induction', 'positive regulation of type 2 immune response', 'response to lipopolysaccharide', 'swimming behavior', 'T cell proliferation', 'tryptophan catabolic process', 'tryptophan catabolic process to kynurenine']["'de novo' NAD biosynthetic process from tryptophan", 'female pregnancy', 'inflammatory response', 'kynurenic acid biosynthetic process', 'multicellular organismal response to stress', 'negative regulation of interleukin-10 production', 'negative regulation of T cell apoptotic process', 'negative regulation of T cell proliferation', 'positive regulation of chronic inflammatory response', 'positive regulation of interleukin-12 production', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell tolerance induction', 'positive regulation of type 2 immune response', 'response to lipopolysaccharide', 'swimming behavior', 'T cell proliferation', 'tryptophan catabolic process', 'tryptophan catabolic process to kynurenine']
Transforming acidic coiled-coil-containing protein 3
828
Transforming acidic coiled-coil-containing protein 3
828
3.1
61
0.52
Q9Y6A5Q9Y6A5['cell division', 'cell population proliferation', 'cerebral cortex development', 'metaphase/anaphase transition of mitotic cell cycle', 'microtubule cytoskeleton organization', 'microtubule cytoskeleton organization involved in mitosis', 'mitotic spindle organization', 'regulation of mitotic spindle organization']['cell division', 'cell population proliferation', 'cerebral cortex development', 'metaphase/anaphase transition of mitotic cell cycle', 'microtubule cytoskeleton organization', 'microtubule cytoskeleton organization involved in mitosis', 'mitotic spindle organization', 'regulation of mitotic spindle organization']
Ketohexokinase
98
Ketohexokinase
98
3.1
92
0.35
P50053P50053['fructose metabolic process', 'regulation of glycogen metabolic process', 'response to fructose', 'response to glucose', 'response to insulin', 'response to sucrose', 'response to zinc ion']['fructose metabolic process', 'regulation of glycogen metabolic process', 'response to fructose', 'response to glucose', 'response to insulin', 'response to sucrose', 'response to zinc ion']
Spermine synthase
347
Spermine synthase
347
3.1
76
0.42
P52788P52788['methionine metabolic process', 'polyamine metabolic process', 'spermine biosynthetic process']['methionine metabolic process', 'polyamine metabolic process', 'spermine biosynthetic process']
Filamin-A
59
Filamin-A
59
3.1
48
0.67
P21333P21333['actin crosslink formation', 'actin cytoskeleton reorganization', 'adenylate cyclase-inhibiting dopamine receptor signaling pathway', 'angiogenesis', 'blood coagulation, intrinsic pathway', 'blood vessel remodeling', 'cell-cell junction organization', 'cilium assembly', 'cytoplasmic sequestering of protein', 'early endosome to late endosome transport', 'epithelial to mesenchymal transition', 'establishment of protein localization', 'heart morphogenesis', 'megakaryocyte development', 'mitotic spindle assembly', 'negative regulation of apoptotic process', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of neuron projection development', 'negative regulation of protein catabolic process', 'negative regulation of transcription by RNA polymerase I', 'platelet aggregation', 'positive regulation of axon regeneration', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of integrin-mediated signaling pathway', 'positive regulation of platelet activation', 'positive regulation of potassium ion transmembrane transport', 'positive regulation of protein import into nucleus', 'positive regulation of substrate adhesion-dependent cell spreading', 'protein localization to cell surface', 'protein localization to plasma membrane', 'protein stabilization', 'receptor clustering', 'regulation of actin filament bundle assembly', 'regulation of cell migration', 'regulation of membrane repolarization during atrial cardiac muscle cell action potential', 'regulation of membrane repolarization during cardiac muscle cell action potential', 'release of sequestered calcium ion into cytosol', 'semaphorin-plexin signaling pathway', 'synapse organization', 'tubulin deacetylation', 'wound healing, spreading of cells']['actin crosslink formation', 'actin cytoskeleton reorganization', 'adenylate cyclase-inhibiting dopamine receptor signaling pathway', 'angiogenesis', 'blood coagulation, intrinsic pathway', 'blood vessel remodeling', 'cell-cell junction organization', 'cilium assembly', 'cytoplasmic sequestering of protein', 'early endosome to late endosome transport', 'epithelial to mesenchymal transition', 'establishment of protein localization', 'heart morphogenesis', 'megakaryocyte development', 'mitotic spindle assembly', 'negative regulation of apoptotic process', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of neuron projection development', 'negative regulation of protein catabolic process', 'negative regulation of transcription by RNA polymerase I', 'platelet aggregation', 'positive regulation of axon regeneration', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of integrin-mediated signaling pathway', 'positive regulation of platelet activation', 'positive regulation of potassium ion transmembrane transport', 'positive regulation of protein import into nucleus', 'positive regulation of substrate adhesion-dependent cell spreading', 'protein localization to cell surface', 'protein localization to plasma membrane', 'protein stabilization', 'receptor clustering', 'regulation of actin filament bundle assembly', 'regulation of cell migration', 'regulation of membrane repolarization during atrial cardiac muscle cell action potential', 'regulation of membrane repolarization during cardiac muscle cell action potential', 'release of sequestered calcium ion into cytosol', 'semaphorin-plexin signaling pathway', 'synapse organization', 'tubulin deacetylation', 'wound healing, spreading of cells']
Transforming growth factor beta-1 proprotein
223
Transforming growth factor beta-1 proprotein
223
3.1
71
0.45
P07200P07200['adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains', 'aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'branch elongation involved in mammary gland duct branching', 'bronchiole development', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'cellular calcium ion homeostasis', 'cellular response to ionizing radiation', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'chondrocyte differentiation', 'columnar/cuboidal epithelial cell maturation', 'common-partner SMAD protein phosphorylation', 'embryonic liver development', 'enamel mineralization', 'endoderm development', 'epidermal growth factor receptor signaling pathway', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'face morphogenesis', 'gene expression', 'germ cell migration', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'Langerhans cell differentiation', 'lens fiber cell differentiation', 'lipopolysaccharide-mediated signaling pathway', 'lung alveolus development', 'lymph node development', 'mammary gland branching involved in thelarche', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'muscle cell cellular homeostasis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of epithelial cell proliferation', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of interleukin-17 production', 'negative regulation of macrophage cytokine production', 'negative regulation of myoblast differentiation', 'negative regulation of ossification', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of T cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'Notch signaling pathway', 'oligodendrocyte development', 'ossification involved in bone remodeling', 'osteoclast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'phospholipid homeostasis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of histone acetylation', 'positive regulation of histone deacetylation', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of odontogenesis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor clustering', 'positive regulation of regulatory T cell differentiation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stem cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of actin cytoskeleton reorganization', 'regulation of binding', 'regulation of branching involved in mammary gland duct morphogenesis', 'regulation of cartilage development', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of interleukin-23 production', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of sodium ion transport', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulatory T cell differentiation', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'stem cell proliferation', 'surfactant homeostasis', 'T cell homeostasis', 'T cell proliferation', 'tolerance induction to self antigen', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'ureteric bud development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains', 'aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'branch elongation involved in mammary gland duct branching', 'bronchiole development', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'cellular calcium ion homeostasis', 'cellular response to ionizing radiation', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'chondrocyte differentiation', 'columnar/cuboidal epithelial cell maturation', 'common-partner SMAD protein phosphorylation', 'embryonic liver development', 'enamel mineralization', 'endoderm development', 'epidermal growth factor receptor signaling pathway', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'face morphogenesis', 'gene expression', 'germ cell migration', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'Langerhans cell differentiation', 'lens fiber cell differentiation', 'lipopolysaccharide-mediated signaling pathway', 'lung alveolus development', 'lymph node development', 'mammary gland branching involved in thelarche', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'muscle cell cellular homeostasis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of epithelial cell proliferation', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of interleukin-17 production', 'negative regulation of macrophage cytokine production', 'negative regulation of myoblast differentiation', 'negative regulation of ossification', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of T cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'Notch signaling pathway', 'oligodendrocyte development', 'ossification involved in bone remodeling', 'osteoclast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'phospholipid homeostasis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of histone acetylation', 'positive regulation of histone deacetylation', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of odontogenesis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor clustering', 'positive regulation of regulatory T cell differentiation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stem cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of actin cytoskeleton reorganization', 'regulation of binding', 'regulation of branching involved in mammary gland duct morphogenesis', 'regulation of cartilage development', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of interleukin-23 production', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of sodium ion transport', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulatory T cell differentiation', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'stem cell proliferation', 'surfactant homeostasis', 'T cell homeostasis', 'T cell proliferation', 'tolerance induction to self antigen', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'ureteric bud development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']
NF-kappa-B essential modulator
54
NF-kappa-B essential modulator
54
3.2
48
0.66
Q9Y6K9Q9Y6K9['anoikis', 'apoptotic process', 'cellular response to DNA damage stimulus', 'establishment of vesicle localization', 'I-kappaB kinase/NF-kappaB signaling', 'immune response', 'inflammatory response', 'innate immune response', 'negative regulation of neuron death', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of macroautophagy', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of T cell receptor signaling pathway', 'positive regulation of transcription by RNA polymerase II', 'protein-containing complex assembly', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'response to virus', 'T cell receptor signaling pathway']['anoikis', 'apoptotic process', 'cellular response to DNA damage stimulus', 'establishment of vesicle localization', 'I-kappaB kinase/NF-kappaB signaling', 'immune response', 'inflammatory response', 'innate immune response', 'negative regulation of neuron death', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of macroautophagy', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of T cell receptor signaling pathway', 'positive regulation of transcription by RNA polymerase II', 'protein-containing complex assembly', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'response to virus', 'T cell receptor signaling pathway']
Lysine-specific histone demethylase 2
278
Lysine-specific histone demethylase 2
278
3.1
52
0.61
Q8NB78Q8NB78['DNA methylation involved in gamete generation', 'histone H3-K4 demethylation', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase II', 'regulation of DNA methylation', 'regulation of gene expression by genomic imprinting']['DNA methylation involved in gamete generation', 'histone H3-K4 demethylation', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase II', 'regulation of DNA methylation', 'regulation of gene expression by genomic imprinting']
Transforming growth factor beta-2 proprotein
379
Transforming growth factor beta-2 proprotein
379
3.1
95
0.34
P61812P61812['activation of protein kinase activity', 'ascending aorta morphogenesis', 'atrial septum morphogenesis', 'atrial septum primum morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'cardiac epithelial to mesenchymal transition', 'cardiac muscle cell proliferation', 'cardiac right ventricle morphogenesis', 'cardioblast differentiation', 'cell death', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'collagen fibril organization', 'cranial skeletal system development', 'dopamine biosynthetic process', 'embryo development ending in birth or egg hatching', 'embryonic digestive tract development', 'embryonic limb morphogenesis', 'endocardial cushion fusion', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'extrinsic apoptotic signaling pathway', 'eye development', 'generation of neurons', 'glial cell migration', 'hair follicle development', 'hair follicle morphogenesis', 'heart development', 'heart morphogenesis', 'heart valve morphogenesis', 'hemopoiesis', 'inner ear development', 'kidney development', 'male gonad development', 'membranous septum morphogenesis', 'negative regulation of alkaline phosphatase activity', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'negative regulation of gene expression', 'negative regulation of macrophage cytokine production', 'negative regulation of Ras protein signal transduction', 'neural retina development', 'neural tube closure', 'neuron development', 'neutrophil chemotaxis', 'odontogenesis', 'outflow tract septum morphogenesis', 'pathway-restricted SMAD protein phosphorylation', 'pharyngeal arch artery morphogenesis', 'positive regulation of cardioblast differentiation', 'positive regulation of cell adhesion mediated by integrin', 'positive regulation of cell cycle', 'positive regulation of cell division', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'positive regulation of heart contraction', 'positive regulation of immune response', 'positive regulation of integrin biosynthetic process', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of Notch signaling pathway', 'positive regulation of ossification', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of stress-activated MAPK cascade', 'positive regulation of timing of catagen', 'protein phosphorylation', 'pulmonary valve morphogenesis', 'regulation of apoptotic process involved in outflow tract morphogenesis', 'regulation of cell population proliferation', 'regulation of timing of catagen', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to progesterone', 'response to wounding', 'response to xenobiotic stimulus', 'salivary gland morphogenesis', 'secondary palate development', 'skeletal system development', 'SMAD protein signal transduction', 'somatic stem cell division', 'substantia propria of cornea development', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'uterus development', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis', 'wound healing']['activation of protein kinase activity', 'ascending aorta morphogenesis', 'atrial septum morphogenesis', 'atrial septum primum morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'cardiac epithelial to mesenchymal transition', 'cardiac muscle cell proliferation', 'cardiac right ventricle morphogenesis', 'cardioblast differentiation', 'cell death', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'collagen fibril organization', 'cranial skeletal system development', 'dopamine biosynthetic process', 'embryo development ending in birth or egg hatching', 'embryonic digestive tract development', 'embryonic limb morphogenesis', 'endocardial cushion fusion', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'extrinsic apoptotic signaling pathway', 'eye development', 'generation of neurons', 'glial cell migration', 'hair follicle development', 'hair follicle morphogenesis', 'heart development', 'heart morphogenesis', 'heart valve morphogenesis', 'hemopoiesis', 'inner ear development', 'kidney development', 'male gonad development', 'membranous septum morphogenesis', 'negative regulation of alkaline phosphatase activity', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'negative regulation of gene expression', 'negative regulation of macrophage cytokine production', 'negative regulation of Ras protein signal transduction', 'neural retina development', 'neural tube closure', 'neuron development', 'neutrophil chemotaxis', 'odontogenesis', 'outflow tract septum morphogenesis', 'pathway-restricted SMAD protein phosphorylation', 'pharyngeal arch artery morphogenesis', 'positive regulation of cardioblast differentiation', 'positive regulation of cell adhesion mediated by integrin', 'positive regulation of cell cycle', 'positive regulation of cell division', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'positive regulation of heart contraction', 'positive regulation of immune response', 'positive regulation of integrin biosynthetic process', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of Notch signaling pathway', 'positive regulation of ossification', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of stress-activated MAPK cascade', 'positive regulation of timing of catagen', 'protein phosphorylation', 'pulmonary valve morphogenesis', 'regulation of apoptotic process involved in outflow tract morphogenesis', 'regulation of cell population proliferation', 'regulation of timing of catagen', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to progesterone', 'response to wounding', 'response to xenobiotic stimulus', 'salivary gland morphogenesis', 'secondary palate development', 'skeletal system development', 'SMAD protein signal transduction', 'somatic stem cell division', 'substantia propria of cornea development', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'uterus development', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis', 'wound healing']
G-protein-signaling modulator 2
124
G-protein-signaling modulator 2
604
2.0
66
0.74
Q8VDU0Q8VDU0['cell division', 'establishment of mitotic spindle orientation', 'maintenance of centrosome location', 'mitotic spindle organization', 'positive regulation of protein localization to cell cortex', 'positive regulation of spindle assembly', 'Ran protein signal transduction', 'regulation of mitotic spindle organization']['cell division', 'establishment of mitotic spindle orientation', 'maintenance of centrosome location', 'mitotic spindle organization', 'positive regulation of protein localization to cell cortex', 'positive regulation of spindle assembly', 'Ran protein signal transduction', 'regulation of mitotic spindle organization']
Beta-hexosaminidase subunit beta
91
Beta-hexosaminidase subunit beta
137
2.0
65
0.75
P07686P07686['astrocyte cell migration', 'cellular calcium ion homeostasis', 'ganglioside catabolic process', 'glycosaminoglycan metabolic process', 'lipid storage', 'locomotory behavior', 'lysosome organization', 'maintenance of location in cell', 'male courtship behavior', 'myelination', 'neuromuscular process controlling balance', 'neuron cellular homeostasis', 'oligosaccharide catabolic process', 'oogenesis', 'penetration of zona pellucida', 'phospholipid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'protein metabolic process', 'regulation of cell shape', 'sensory perception of sound', 'single fertilization', 'skeletal system development']['astrocyte cell migration', 'cellular calcium ion homeostasis', 'ganglioside catabolic process', 'glycosaminoglycan metabolic process', 'lipid storage', 'locomotory behavior', 'lysosome organization', 'maintenance of location in cell', 'male courtship behavior', 'myelination', 'neuromuscular process controlling balance', 'neuron cellular homeostasis', 'oligosaccharide catabolic process', 'oogenesis', 'penetration of zona pellucida', 'phospholipid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'protein metabolic process', 'regulation of cell shape', 'sensory perception of sound', 'single fertilization', 'skeletal system development']
Fibrinogen beta chain
110
Fibrinogen gamma chain
45
2.0
66
0.74
P02675P02679['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Major prion protein
179
Major prion protein
214
2.0
81
0.61
P04156P04156['activation of protein kinase activity', 'calcium-mediated signaling using intracellular calcium source', 'cell cycle', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to copper ion', 'cellular response to xenobiotic stimulus', 'dendritic spine maintenance', 'learning or memory', 'long-term memory', 'negative regulation of activated T cell proliferation', 'negative regulation of amyloid precursor protein catabolic process', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of calcineurin-NFAT signaling cascade', 'negative regulation of dendritic spine maintenance', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-17 production', 'negative regulation of interleukin-2 production', 'negative regulation of long-term synaptic potentiation', 'negative regulation of protein phosphorylation', 'negative regulation of protein processing', 'negative regulation of T cell receptor signaling pathway', 'neuron projection maintenance', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein targeting to membrane', 'positive regulation of protein tyrosine kinase activity', 'protein destabilization', 'protein homooligomerization', 'regulation of calcium ion import across plasma membrane', 'regulation of glutamate receptor signaling pathway', 'regulation of intracellular calcium activated chloride channel activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of potassium ion transmembrane transport', 'response to amyloid-beta', 'response to cadmium ion', 'response to oxidative stress']['activation of protein kinase activity', 'calcium-mediated signaling using intracellular calcium source', 'cell cycle', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to copper ion', 'cellular response to xenobiotic stimulus', 'dendritic spine maintenance', 'learning or memory', 'long-term memory', 'negative regulation of activated T cell proliferation', 'negative regulation of amyloid precursor protein catabolic process', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of calcineurin-NFAT signaling cascade', 'negative regulation of dendritic spine maintenance', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-17 production', 'negative regulation of interleukin-2 production', 'negative regulation of long-term synaptic potentiation', 'negative regulation of protein phosphorylation', 'negative regulation of protein processing', 'negative regulation of T cell receptor signaling pathway', 'neuron projection maintenance', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein targeting to membrane', 'positive regulation of protein tyrosine kinase activity', 'protein destabilization', 'protein homooligomerization', 'regulation of calcium ion import across plasma membrane', 'regulation of glutamate receptor signaling pathway', 'regulation of intracellular calcium activated chloride channel activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of potassium ion transmembrane transport', 'response to amyloid-beta', 'response to cadmium ion', 'response to oxidative stress']
Serine protease hepsin
153
Serine protease hepsin
277
2.0
87
0.56
P05981P05981['basement membrane disassembly', 'cochlea morphogenesis', 'detection of mechanical stimulus involved in sensory perception of sound', 'negative regulation of apoptotic process', 'negative regulation of epithelial cell proliferation', 'negative regulation of epithelial to mesenchymal transition', 'pilomotor reflex', 'positive regulation by host of viral transcription', 'positive regulation of cell growth', 'positive regulation of gene expression', 'positive regulation of hepatocyte proliferation', 'positive regulation of plasminogen activation', 'positive regulation of thyroid hormone generation', 'potassium ion transmembrane transport', 'proteolysis', 'regulation of cell shape', 'response to thyroid hormone']['basement membrane disassembly', 'cochlea morphogenesis', 'detection of mechanical stimulus involved in sensory perception of sound', 'negative regulation of apoptotic process', 'negative regulation of epithelial cell proliferation', 'negative regulation of epithelial to mesenchymal transition', 'pilomotor reflex', 'positive regulation by host of viral transcription', 'positive regulation of cell growth', 'positive regulation of gene expression', 'positive regulation of hepatocyte proliferation', 'positive regulation of plasminogen activation', 'positive regulation of thyroid hormone generation', 'potassium ion transmembrane transport', 'proteolysis', 'regulation of cell shape', 'response to thyroid hormone']
Immunoglobulin heavy constant epsilon
209
Immunoglobulin heavy constant epsilon
121
2.0
69
0.71
P01854P01854['adaptive immune response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
Insulin
91
Insulin
31
2.0
70
0.7
P01317P01317['estradiol secretion', 'feeding behavior', 'glucose import in response to insulin stimulus', 'glucose metabolic process', 'negative regulation of apoptotic process', 'negative regulation of appetite', 'negative regulation of lactation', 'negative regulation of lipid catabolic process', 'positive regulation of blood circulation', 'positive regulation of cell maturation', 'positive regulation of gene expression', 'positive regulation of insulin secretion', 'positive regulation of lactation', 'positive regulation of mammary gland epithelial cell proliferation', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Rho protein signal transduction', 'protein secretion', 'response to butyrate', 'response to food', 'response to glucose', 'response to growth hormone', 'response to heat', 'response to L-arginine', 'response to nutrient levels']['estradiol secretion', 'feeding behavior', 'glucose import in response to insulin stimulus', 'glucose metabolic process', 'negative regulation of apoptotic process', 'negative regulation of appetite', 'negative regulation of lactation', 'negative regulation of lipid catabolic process', 'positive regulation of blood circulation', 'positive regulation of cell maturation', 'positive regulation of gene expression', 'positive regulation of insulin secretion', 'positive regulation of lactation', 'positive regulation of mammary gland epithelial cell proliferation', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Rho protein signal transduction', 'protein secretion', 'response to butyrate', 'response to food', 'response to glucose', 'response to growth hormone', 'response to heat', 'response to L-arginine', 'response to nutrient levels']
Collagen alpha-1(III) chain
1285
Collagen alpha-1(III) chain
1268
2.0
67
0.73
P02461P02461['aorta smooth muscle tissue morphogenesis', 'basement membrane organization', 'cell-matrix adhesion', 'cellular response to amino acid stimulus', 'cerebral cortex development', 'chondrocyte differentiation', 'collagen fibril organization', 'digestive tract development', 'elastic fiber assembly', 'endochondral bone morphogenesis', 'extracellular matrix organization', 'fibroblast proliferation', 'heart development', 'in utero embryonic development', 'integrin-mediated signaling pathway', 'layer formation in cerebral cortex', 'limb joint morphogenesis', 'lung development', 'multicellular organism growth', 'negative regulation of immune response', 'negative regulation of neuron migration', 'neuron migration', 'peptide cross-linking', 'platelet activation', 'positive regulation of Rho protein signal transduction', 'response to angiotensin', 'response to cytokine', 'response to radiation', 'skin development', 'supramolecular fiber organization', 'tissue homeostasis', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta1 production', 'wound healing']['aorta smooth muscle tissue morphogenesis', 'basement membrane organization', 'cell-matrix adhesion', 'cellular response to amino acid stimulus', 'cerebral cortex development', 'chondrocyte differentiation', 'collagen fibril organization', 'digestive tract development', 'elastic fiber assembly', 'endochondral bone morphogenesis', 'extracellular matrix organization', 'fibroblast proliferation', 'heart development', 'in utero embryonic development', 'integrin-mediated signaling pathway', 'layer formation in cerebral cortex', 'limb joint morphogenesis', 'lung development', 'multicellular organism growth', 'negative regulation of immune response', 'negative regulation of neuron migration', 'neuron migration', 'peptide cross-linking', 'platelet activation', 'positive regulation of Rho protein signal transduction', 'response to angiotensin', 'response to cytokine', 'response to radiation', 'skin development', 'supramolecular fiber organization', 'tissue homeostasis', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta1 production', 'wound healing']
Isoform 2 of Potassium channel subfamily K member 4
78
Isoform 2 of Potassium channel subfamily K member 4
78
2.2
87
0.53
Q9NYG8-2Q9NYG8-2[][]
Tripartite motif-containing protein 67
702
Tripartite motif-containing protein 67
702
2.2
71
0.65
Q6ZTA4Q6ZTA4['negative regulation of Ras protein signal transduction', 'positive regulation of neuron projection development', 'positive regulation of ubiquitin-dependent protein catabolic process', 'regulation of protein localization']['negative regulation of Ras protein signal transduction', 'positive regulation of neuron projection development', 'positive regulation of ubiquitin-dependent protein catabolic process', 'regulation of protein localization']
Tropomyosin alpha-1 chain
190
Tropomyosin alpha-1 chain
190
2.2
54
0.86
1
✔P04692P04692['actin filament capping', 'actin filament organization', 'cardiac muscle contraction', 'cellular response to reactive oxygen species', 'in utero embryonic development', 'muscle contraction', 'muscle filament sliding', 'negative regulation of cell migration', 'negative regulation of vascular associated smooth muscle cell migration', 'negative regulation of vascular associated smooth muscle cell proliferation', 'positive regulation of ATP-dependent activity', 'positive regulation of cell adhesion', 'positive regulation of heart rate by epinephrine', 'positive regulation of stress fiber assembly', 'regulation of ATP-dependent activity', 'regulation of cell shape', 'ruffle organization', 'sarcomere organization', 'ventricular cardiac muscle tissue morphogenesis', 'wound healing']['actin filament capping', 'actin filament organization', 'cardiac muscle contraction', 'cellular response to reactive oxygen species', 'in utero embryonic development', 'muscle contraction', 'muscle filament sliding', 'negative regulation of cell migration', 'negative regulation of vascular associated smooth muscle cell migration', 'negative regulation of vascular associated smooth muscle cell proliferation', 'positive regulation of ATP-dependent activity', 'positive regulation of cell adhesion', 'positive regulation of heart rate by epinephrine', 'positive regulation of stress fiber assembly', 'regulation of ATP-dependent activity', 'regulation of cell shape', 'ruffle organization', 'sarcomere organization', 'ventricular cardiac muscle tissue morphogenesis', 'wound healing']
Isoform L-VEGF206 of Vascular endothelial growth factor A
257
Isoform L-VEGF206 of Vascular endothelial growth factor A
266
2.2
72
0.64
P15692-14P15692-14[][]
Fibrinogen beta chain
223
Fibrinogen gamma chain
161
2.2
72
0.64
P02675P02679['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Neurturin
164
Neurturin
164
2.0
75
0.65
Q99748Q99748['MAPK cascade', 'nerve development', 'nervous system development', 'neural crest cell migration', 'neuron projection development', 'transmembrane receptor protein tyrosine kinase signaling pathway']['MAPK cascade', 'nerve development', 'nervous system development', 'neural crest cell migration', 'neuron projection development', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Bone morphogenetic protein 2
360
Bone morphogenetic protein 2
360
2.0
88
0.56
P12643P12643['ameloblast differentiation', 'animal organ morphogenesis', 'aortic valve development', 'astrocyte differentiation', 'atrioventricular canal morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'BMP signaling pathway involved in heart development', 'BMP signaling pathway involved in heart induction', 'bone mineralization', 'bone mineralization involved in bone maturation', 'branching involved in ureteric bud morphogenesis', 'cardiac atrium formation', 'cardiac epithelial to mesenchymal transition', 'cardiac jelly development', 'cardiac muscle cell differentiation', 'cardiac muscle tissue morphogenesis', 'cardiocyte differentiation', 'cell fate commitment', 'cell-cell signaling', 'cellular response to BMP stimulus', 'cellular response to organic cyclic compound', 'chondrocyte differentiation', 'corticotropin hormone secreting cell differentiation', 'embryonic heart tube anterior/posterior pattern specification', 'endocardial cushion formation', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'heart development', 'in utero embryonic development', 'inflammatory response', 'inner ear development', 'mesenchymal cell differentiation', 'mesenchymal cell proliferation involved in ureteric bud development', 'mesenchyme development', 'negative regulation of aldosterone biosynthetic process', 'negative regulation of calcium-independent cell-cell adhesion', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cardiac muscle cell differentiation', 'negative regulation of cell cycle', 'negative regulation of cell population proliferation', 'negative regulation of cortisol biosynthetic process', 'negative regulation of gene expression', 'negative regulation of insulin-like growth factor receptor signaling pathway', 'negative regulation of MAP kinase activity', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of steroid biosynthetic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of Wnt signaling pathway involved in heart development', 'Notch signaling pathway', 'odontogenesis of dentin-containing tooth', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'pericardium development', 'positive regulation of apoptotic process', 'positive regulation of astrocyte differentiation', 'positive regulation of bone mineralization', 'positive regulation of cartilage development', 'positive regulation of cell migration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell differentiation', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix constituent secretion', 'positive regulation of fat cell differentiation', 'positive regulation of gene expression', 'positive regulation of MAPK cascade', 'positive regulation of miRNA transcription', 'positive regulation of neuron differentiation', 'positive regulation of odontogenesis', 'positive regulation of ossification', 'positive regulation of osteoblast differentiation', 'positive regulation of osteoblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peroxisome proliferator activated receptor signaling pathway', 'positive regulation of phosphatase activity', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus', 'positive regulation of transcription, DNA-templated', 'positive regulation of Wnt signaling pathway', 'positive regulation of Wnt signaling pathway by BMP signaling pathway', 'protein destabilization', 'protein phosphorylation', 'proteoglycan metabolic process', 'regulation of odontogenesis of dentin-containing tooth', 'regulation of transcription, DNA-templated', 'response to bacterium', 'response to hypoxia', 'skeletal system development', 'SMAD protein signal transduction', 'telencephalon development', 'telencephalon regionalization', 'thyroid-stimulating hormone-secreting cell differentiation', 'transcription by RNA polymerase II', 'Wnt signaling pathway']['ameloblast differentiation', 'animal organ morphogenesis', 'aortic valve development', 'astrocyte differentiation', 'atrioventricular canal morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'BMP signaling pathway involved in heart development', 'BMP signaling pathway involved in heart induction', 'bone mineralization', 'bone mineralization involved in bone maturation', 'branching involved in ureteric bud morphogenesis', 'cardiac atrium formation', 'cardiac epithelial to mesenchymal transition', 'cardiac jelly development', 'cardiac muscle cell differentiation', 'cardiac muscle tissue morphogenesis', 'cardiocyte differentiation', 'cell fate commitment', 'cell-cell signaling', 'cellular response to BMP stimulus', 'cellular response to organic cyclic compound', 'chondrocyte differentiation', 'corticotropin hormone secreting cell differentiation', 'embryonic heart tube anterior/posterior pattern specification', 'endocardial cushion formation', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'heart development', 'in utero embryonic development', 'inflammatory response', 'inner ear development', 'mesenchymal cell differentiation', 'mesenchymal cell proliferation involved in ureteric bud development', 'mesenchyme development', 'negative regulation of aldosterone biosynthetic process', 'negative regulation of calcium-independent cell-cell adhesion', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cardiac muscle cell differentiation', 'negative regulation of cell cycle', 'negative regulation of cell population proliferation', 'negative regulation of cortisol biosynthetic process', 'negative regulation of gene expression', 'negative regulation of insulin-like growth factor receptor signaling pathway', 'negative regulation of MAP kinase activity', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of steroid biosynthetic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of Wnt signaling pathway involved in heart development', 'Notch signaling pathway', 'odontogenesis of dentin-containing tooth', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'pericardium development', 'positive regulation of apoptotic process', 'positive regulation of astrocyte differentiation', 'positive regulation of bone mineralization', 'positive regulation of cartilage development', 'positive regulation of cell migration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell differentiation', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix constituent secretion', 'positive regulation of fat cell differentiation', 'positive regulation of gene expression', 'positive regulation of MAPK cascade', 'positive regulation of miRNA transcription', 'positive regulation of neuron differentiation', 'positive regulation of odontogenesis', 'positive regulation of ossification', 'positive regulation of osteoblast differentiation', 'positive regulation of osteoblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peroxisome proliferator activated receptor signaling pathway', 'positive regulation of phosphatase activity', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus', 'positive regulation of transcription, DNA-templated', 'positive regulation of Wnt signaling pathway', 'positive regulation of Wnt signaling pathway by BMP signaling pathway', 'protein destabilization', 'protein phosphorylation', 'proteoglycan metabolic process', 'regulation of odontogenesis of dentin-containing tooth', 'regulation of transcription, DNA-templated', 'response to bacterium', 'response to hypoxia', 'skeletal system development', 'SMAD protein signal transduction', 'telencephalon development', 'telencephalon regionalization', 'thyroid-stimulating hormone-secreting cell differentiation', 'transcription by RNA polymerase II', 'Wnt signaling pathway']
Poly(rC)-binding protein 1
54
Poly(rC)-binding protein 1
54
2.0
51
0.96
Q15365Q15365['positive regulation of transcription by RNA polymerase II', 'regulation of gene expression', 'regulation of RNA metabolic process', 'viral RNA genome replication']['positive regulation of transcription by RNA polymerase II', 'regulation of gene expression', 'regulation of RNA metabolic process', 'viral RNA genome replication']
Fibrinogen alpha chain
64
Fibrinogen gamma chain
49
2.0
82
0.6
P02671P02679['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Granzyme A
105
Granzyme A
105
2.0
54
0.91
P12544P12544['apoptotic process', 'cytolysis', 'cytotoxic T cell pyroptotic process', 'granzyme-mediated programmed cell death signaling pathway', 'immune response', 'negative regulation of DNA binding', 'negative regulation of endodeoxyribonuclease activity', 'negative regulation of oxidoreductase activity', 'positive regulation of apoptotic process', 'proteolysis involved in protein catabolic process', 'pyroptosis', 'response to bacterium']['apoptotic process', 'cytolysis', 'cytotoxic T cell pyroptotic process', 'granzyme-mediated programmed cell death signaling pathway', 'immune response', 'negative regulation of DNA binding', 'negative regulation of endodeoxyribonuclease activity', 'negative regulation of oxidoreductase activity', 'positive regulation of apoptotic process', 'proteolysis involved in protein catabolic process', 'pyroptosis', 'response to bacterium']
Nucleoprotein TPR
75
Nucleoprotein TPR
75
2.0
55
0.89
P12270P12270['cell division', 'cellular response to heat', 'cellular response to interferon-alpha', 'mitotic spindle assembly checkpoint signaling', 'mRNA export from nucleus', 'mRNA export from nucleus in response to heat stress', 'negative regulation of RNA export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of translational initiation', 'nuclear pore organization', 'nucleocytoplasmic transport', 'positive regulation of heterochromatin assembly', 'positive regulation of intracellular protein transport', 'positive regulation of mitotic cell cycle spindle assembly checkpoint', 'positive regulation of protein export from nucleus', 'positive regulation of protein import into nucleus', 'protein import into nucleus', 'regulation of mitotic sister chromatid separation', 'regulation of mitotic spindle assembly', 'regulation of protein localization', 'response to epidermal growth factor', 'RNA export from nucleus', 'RNA import into nucleus']['cell division', 'cellular response to heat', 'cellular response to interferon-alpha', 'mitotic spindle assembly checkpoint signaling', 'mRNA export from nucleus', 'mRNA export from nucleus in response to heat stress', 'negative regulation of RNA export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of translational initiation', 'nuclear pore organization', 'nucleocytoplasmic transport', 'positive regulation of heterochromatin assembly', 'positive regulation of intracellular protein transport', 'positive regulation of mitotic cell cycle spindle assembly checkpoint', 'positive regulation of protein export from nucleus', 'positive regulation of protein import into nucleus', 'protein import into nucleus', 'regulation of mitotic sister chromatid separation', 'regulation of mitotic spindle assembly', 'regulation of protein localization', 'response to epidermal growth factor', 'RNA export from nucleus', 'RNA import into nucleus']
Trypsin
124
Trypsin
191
2.0
64
0.77
P00761P00761['digestion', 'proteolysis']['digestion', 'proteolysis']
T-cell receptor, sp3.4 alpha chain
161
Human nkt tcr beta chain
176
2.0
74
0.66
K7N5N2K7N5M4[][]
Ubiquitin carboxyl-terminal hydrolase 11
204
Ubiquitin carboxyl-terminal hydrolase 11
204
2.0
46
1.07
Q5D006Q5D006['protein deubiquitination', 'ubiquitin-dependent protein catabolic process']['protein deubiquitination', 'ubiquitin-dependent protein catabolic process']
Prothrombin
339
Prothrombin
485
2.0
80
0.61
P00735P00735['acute-phase response', 'platelet activation', 'positive regulation of blood coagulation', 'protein polymerization', 'proteolysis']['acute-phase response', 'platelet activation', 'positive regulation of blood coagulation', 'protein polymerization', 'proteolysis']
Ubiquitin carboxyl-terminal hydrolase 7
315
Ubiquitin carboxyl-terminal hydrolase 7
315
2.0
58
0.85
Q93009Q93009['histone H2B conserved C-terminal lysine deubiquitination', 'maintenance of DNA methylation', 'monoubiquitinated protein deubiquitination', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of DNA demethylation', 'protein deubiquitination', 'protein K63-linked deubiquitination', 'protein stabilization', 'protein ubiquitination', 'regulation of circadian rhythm', 'regulation of DNA-binding transcription factor activity', 'regulation of gluconeogenesis', 'regulation of protein stability', 'regulation of retrograde transport, endosome to Golgi', 'regulation of signal transduction by p53 class mediator', 'regulation of telomere capping', 'rhythmic process', 'transcription-coupled nucleotide-excision repair', 'ubiquitin-dependent protein catabolic process']['histone H2B conserved C-terminal lysine deubiquitination', 'maintenance of DNA methylation', 'monoubiquitinated protein deubiquitination', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of DNA demethylation', 'protein deubiquitination', 'protein K63-linked deubiquitination', 'protein stabilization', 'protein ubiquitination', 'regulation of circadian rhythm', 'regulation of DNA-binding transcription factor activity', 'regulation of gluconeogenesis', 'regulation of protein stability', 'regulation of retrograde transport, endosome to Golgi', 'regulation of signal transduction by p53 class mediator', 'regulation of telomere capping', 'rhythmic process', 'transcription-coupled nucleotide-excision repair', 'ubiquitin-dependent protein catabolic process']
Potassium channel subfamily K member 10
118
Potassium channel subfamily K member 10
118
2.0
42
1.17
P57789P57789['memory', 'potassium ion transmembrane transport', 'regulation of ion transmembrane transport', 'signal transduction', 'stabilization of membrane potential']['memory', 'potassium ion transmembrane transport', 'regulation of ion transmembrane transport', 'signal transduction', 'stabilization of membrane potential']
Vascular endothelial growth factor B
81
Vascular endothelial growth factor B
72
2.0
73
0.67
P49765P49765['cardiac muscle contraction', 'coronary vasculature development', 'induction of positive chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of gene expression', 'negative regulation of neuron apoptotic process', 'positive regulation of angiogenesis', 'positive regulation of cell division', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'positive regulation of vascular wound healing', 'protein O-linked glycosylation', 'response to hypoxia', 'sprouting angiogenesis', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor signaling pathway']['cardiac muscle contraction', 'coronary vasculature development', 'induction of positive chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of gene expression', 'negative regulation of neuron apoptotic process', 'positive regulation of angiogenesis', 'positive regulation of cell division', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'positive regulation of vascular wound healing', 'protein O-linked glycosylation', 'response to hypoxia', 'sprouting angiogenesis', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor signaling pathway']
Growth/differentiation factor 8
339
Growth/differentiation factor 8
339
2.0
84
0.58
O14793O14793['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'muscle organ development', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'muscle organ development', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
Growth/differentiation factor 11
371
Growth/differentiation factor 11
371
2.0
79
0.62
O95390O95390['amacrine cell differentiation', 'camera-type eye morphogenesis', 'cell population proliferation', 'mesoderm development', 'metanephros development', 'negative regulation of amacrine cell differentiation', 'negative regulation of cell population proliferation', 'nervous system development', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'roof of mouth development', 'skeletal system development', 'SMAD protein signal transduction', 'spinal cord anterior/posterior patterning', 'type B pancreatic cell maturation', 'ureteric bud development']['amacrine cell differentiation', 'camera-type eye morphogenesis', 'cell population proliferation', 'mesoderm development', 'metanephros development', 'negative regulation of amacrine cell differentiation', 'negative regulation of cell population proliferation', 'nervous system development', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'roof of mouth development', 'skeletal system development', 'SMAD protein signal transduction', 'spinal cord anterior/posterior patterning', 'type B pancreatic cell maturation', 'ureteric bud development']
Zinc finger protein 276
196
Zinc finger protein 276
196
2.2
62
0.72
A0A5F9DAT3A0A5F9DAT3[][]
Poly(A)-specific ribonuclease PARN
108
Poly(A)-specific ribonuclease PARN
108
2.2
81
0.56
O95453O95453["box H/ACA RNA 3'-end processing", 'female gamete generation', 'miRNA catabolic process', 'ncRNA deadenylation', 'nuclear-transcribed mRNA catabolic process, nonsense-mediated decay', 'nuclear-transcribed mRNA poly(A) tail shortening', "polyadenylation-dependent snoRNA 3'-end processing", 'positive regulation of telomerase activity', 'positive regulation of telomere maintenance via telomerase', 'regulation of telomerase RNA localization to Cajal body', 'RNA modification', 'RNA phosphodiester bond hydrolysis, exonucleolytic', 'telomerase RNA stabilization']["box H/ACA RNA 3'-end processing", 'female gamete generation', 'miRNA catabolic process', 'ncRNA deadenylation', 'nuclear-transcribed mRNA catabolic process, nonsense-mediated decay', 'nuclear-transcribed mRNA poly(A) tail shortening', "polyadenylation-dependent snoRNA 3'-end processing", 'positive regulation of telomerase activity', 'positive regulation of telomere maintenance via telomerase', 'regulation of telomerase RNA localization to Cajal body', 'RNA modification', 'RNA phosphodiester bond hydrolysis, exonucleolytic', 'telomerase RNA stabilization']
Actin, alpha skeletal muscle
376
Actin, alpha skeletal muscle
376
2.2
59
0.77
P68135P68135['actin filament bundle assembly', 'actin filament polymerization', 'mesenchyme migration', 'positive regulation of gene expression', 'skeletal muscle fiber development', 'skeletal muscle thin filament assembly']['actin filament bundle assembly', 'actin filament polymerization', 'mesenchyme migration', 'positive regulation of gene expression', 'skeletal muscle fiber development', 'skeletal muscle thin filament assembly']
Kelch-like ECH-associated protein 1
434
Kelch-like ECH-associated protein 1
434
2.5
47
0.85
Q14145Q14145['cellular response to interleukin-4', 'cellular response to oxidative stress', 'cytoplasmic sequestering of transcription factor', 'in utero embryonic development', 'negative regulation of DNA-binding transcription factor activity', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'protein ubiquitination', 'regulation of autophagy', 'regulation of epidermal cell differentiation', 'ubiquitin-dependent protein catabolic process']['cellular response to interleukin-4', 'cellular response to oxidative stress', 'cytoplasmic sequestering of transcription factor', 'in utero embryonic development', 'negative regulation of DNA-binding transcription factor activity', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'protein ubiquitination', 'regulation of autophagy', 'regulation of epidermal cell differentiation', 'ubiquitin-dependent protein catabolic process']
PRKCA-binding protein
44
PRKCA-binding protein
46
2.3
68
0.65
Q9NRD5Q9NRD5['cellular response to decreased oxygen levels', 'cellular response to glucose starvation', 'dendritic spine maintenance', 'dendritic spine organization', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'glial cell development', 'intracellular protein transport', 'long-term synaptic depression', 'monoamine transport', 'negative regulation of Arp2/3 complex-mediated actin nucleation', 'neuronal ion channel clustering', 'positive regulation of receptor internalization', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'receptor clustering', 'regulation of Arp2/3 complex-mediated actin nucleation', 'regulation of insulin secretion', 'retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum']['cellular response to decreased oxygen levels', 'cellular response to glucose starvation', 'dendritic spine maintenance', 'dendritic spine organization', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'glial cell development', 'intracellular protein transport', 'long-term synaptic depression', 'monoamine transport', 'negative regulation of Arp2/3 complex-mediated actin nucleation', 'neuronal ion channel clustering', 'positive regulation of receptor internalization', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'receptor clustering', 'regulation of Arp2/3 complex-mediated actin nucleation', 'regulation of insulin secretion', 'retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum']
Sorting nexin-32
49
Sorting nexin-32
49
2.1
54
0.88
Q86XE0Q86XE0['protein transport', 'regulation of macroautophagy', 'retrograde transport, endosome to Golgi']['protein transport', 'regulation of macroautophagy', 'retrograde transport, endosome to Golgi']
Dynamin-3
676
Dynamin-3
676
2.1
70
0.68
Q9UQ16Q9UQ16['endocytosis', 'filopodium assembly', 'negative regulation of dendritic spine morphogenesis', 'positive regulation of filopodium assembly', 'positive regulation of synaptic vesicle recycling', 'postsynaptic neurotransmitter receptor internalization', 'receptor internalization', 'synapse assembly', 'synaptic vesicle endocytosis']['endocytosis', 'filopodium assembly', 'negative regulation of dendritic spine morphogenesis', 'positive regulation of filopodium assembly', 'positive regulation of synaptic vesicle recycling', 'postsynaptic neurotransmitter receptor internalization', 'receptor internalization', 'synapse assembly', 'synaptic vesicle endocytosis']
Ubiquitin carboxyl-terminal hydrolase 5
195
Ubiquitin carboxyl-terminal hydrolase 5
195
2.1
49
0.95
P45974P45974['positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'protein deubiquitination', 'protein K48-linked deubiquitination', 'protein ubiquitination', 'ubiquitin-dependent protein catabolic process']['positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'protein deubiquitination', 'protein K48-linked deubiquitination', 'protein ubiquitination', 'ubiquitin-dependent protein catabolic process']
ADP-ribosylation factor-binding protein GGA1
77
ADP-ribosylation factor-binding protein GGA1
77
2.5
74
0.54
Q9UJY5Q9UJY5['Golgi to plasma membrane protein transport', 'Golgi to plasma membrane transport', 'intracellular protein transport', 'positive regulation of protein catabolic process', 'protein catabolic process', 'protein localization', 'protein localization to cell surface', 'protein localization to ciliary membrane', 'retrograde transport, endosome to Golgi', 'toxin transport']['Golgi to plasma membrane protein transport', 'Golgi to plasma membrane transport', 'intracellular protein transport', 'positive regulation of protein catabolic process', 'protein catabolic process', 'protein localization', 'protein localization to cell surface', 'protein localization to ciliary membrane', 'retrograde transport, endosome to Golgi', 'toxin transport']
Replication protein A 32 kDa subunit
219
Replication protein A 32 kDa subunit
219
2.1
76
0.61
P15927P15927['base-excision repair', 'DNA replication', 'double-strand break repair via homologous recombination', 'mismatch repair', 'mitotic G1 DNA damage checkpoint signaling', 'nucleotide-excision repair', 'protein localization to chromosome', 'regulation of DNA damage checkpoint', 'regulation of double-strand break repair via homologous recombination', 'telomere maintenance']['base-excision repair', 'DNA replication', 'double-strand break repair via homologous recombination', 'mismatch repair', 'mitotic G1 DNA damage checkpoint signaling', 'nucleotide-excision repair', 'protein localization to chromosome', 'regulation of DNA damage checkpoint', 'regulation of double-strand break repair via homologous recombination', 'telomere maintenance']
Filamin-C
1653
Filamin-C
1653
2.1
76
0.64
Q14315Q14315['sarcomere organization']['sarcomere organization']
Potassium channel subfamily K member 4
52
Potassium channel subfamily K member 4
52
2.1
62
0.78
O88454O88454['cellular response to alkaline pH', 'cellular response to fatty acid', 'cellular response to mechanical stimulus', 'cellular response to temperature stimulus', 'detection of mechanical stimulus involved in sensory perception of touch', 'memory', 'potassium ion transmembrane transport', 'regulation of ion transmembrane transport', 'sensory perception of pain', 'sensory perception of temperature stimulus', 'stabilization of membrane potential']['cellular response to alkaline pH', 'cellular response to fatty acid', 'cellular response to mechanical stimulus', 'cellular response to temperature stimulus', 'detection of mechanical stimulus involved in sensory perception of touch', 'memory', 'potassium ion transmembrane transport', 'regulation of ion transmembrane transport', 'sensory perception of pain', 'sensory perception of temperature stimulus', 'stabilization of membrane potential']
Nitric oxide synthase, inducible
115
Nitric oxide synthase, inducible
115
2.1
80
0.6
P35228P35228['arginine catabolic process', 'cell redox homeostasis', 'cellular response to interferon-gamma', 'cellular response to lipopolysaccharide', 'cellular response to xenobiotic stimulus', 'circadian rhythm', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'inflammatory response', 'innate immune response in mucosa', 'negative regulation of blood pressure', 'negative regulation of gene expression', 'negative regulation of protein catabolic process', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of guanylate cyclase activity', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of killing of cells of another organism', 'positive regulation of leukocyte mediated cytotoxicity', 'prostaglandin secretion', 'regulation of cell population proliferation', 'regulation of cellular respiration', 'regulation of cytokine production involved in inflammatory response', 'regulation of insulin secretion', 'response to bacterium', 'response to hormone', 'response to hypoxia', 'response to lipopolysaccharide', 'superoxide metabolic process']['arginine catabolic process', 'cell redox homeostasis', 'cellular response to interferon-gamma', 'cellular response to lipopolysaccharide', 'cellular response to xenobiotic stimulus', 'circadian rhythm', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'inflammatory response', 'innate immune response in mucosa', 'negative regulation of blood pressure', 'negative regulation of gene expression', 'negative regulation of protein catabolic process', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of guanylate cyclase activity', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of killing of cells of another organism', 'positive regulation of leukocyte mediated cytotoxicity', 'prostaglandin secretion', 'regulation of cell population proliferation', 'regulation of cellular respiration', 'regulation of cytokine production involved in inflammatory response', 'regulation of insulin secretion', 'response to bacterium', 'response to hormone', 'response to hypoxia', 'response to lipopolysaccharide', 'superoxide metabolic process']
Artemin
187
Artemin
187
2.1
72
0.67
Q5T4W7Q5T4W7['axon guidance', 'induction of positive chemotaxis', 'lymphocyte migration into lymphoid organs', 'neuroblast proliferation', 'peripheral nervous system development', "Peyer's patch morphogenesis", 'signal transduction']['axon guidance', 'induction of positive chemotaxis', 'lymphocyte migration into lymphoid organs', 'neuroblast proliferation', 'peripheral nervous system development', "Peyer's patch morphogenesis", 'signal transduction']
Thioredoxin reductase 1, cytoplasmic
608
Thioredoxin reductase 1, cytoplasmic
608
2.1
66
0.73
Q16881Q16881['cell population proliferation', 'cell redox homeostasis', 'mesoderm formation', 'signal transduction']['cell population proliferation', 'cell redox homeostasis', 'mesoderm formation', 'signal transduction']
Potassium channel subfamily K member 1
69
Potassium channel subfamily K member 1
69
2.1
44
1.09
O00180O00180['potassium ion transmembrane transport', 'potassium ion transport', 'regulation of resting membrane potential', 'response to nicotine', 'sodium ion transmembrane transport', 'stabilization of membrane potential']['potassium ion transmembrane transport', 'potassium ion transport', 'regulation of resting membrane potential', 'response to nicotine', 'sodium ion transmembrane transport', 'stabilization of membrane potential']
SUN domain-containing protein 1
630
Nesprin-1
8774
2.1
50
0.96
O94901Q8NF91['centrosome localization', 'homologous chromosome pairing at meiosis', 'meiotic attachment of telomere to nuclear envelope', 'nuclear envelope organization', 'nuclear matrix anchoring at nuclear membrane', 'nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration', 'spermatogenesis']['Golgi organization', 'muscle cell differentiation', 'nuclear matrix anchoring at nuclear membrane', 'nucleus organization', 'spermatogenesis']
Interleukin-5
63
Interleukin-5
105
2.1
68
0.71
P05113P05113['cytokine-mediated signaling pathway', 'immune response', 'inflammatory response', 'peptidyl-tyrosine phosphorylation', 'positive regulation of B cell proliferation', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of eosinophil differentiation', 'positive regulation of immunoglobulin production', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of podosome assembly', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of transcription, DNA-templated']['cytokine-mediated signaling pathway', 'immune response', 'inflammatory response', 'peptidyl-tyrosine phosphorylation', 'positive regulation of B cell proliferation', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of eosinophil differentiation', 'positive regulation of immunoglobulin production', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of podosome assembly', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of transcription, DNA-templated']
Bone morphogenetic protein 3
436
Bone morphogenetic protein 3
436
2.1
91
0.53
P12645P12645['cartilage development', 'cell-cell signaling', 'osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'skeletal system development', 'SMAD protein signal transduction']['cartilage development', 'cell-cell signaling', 'osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'skeletal system development', 'SMAD protein signal transduction']
Platelet-derived growth factor subunit B
124
Platelet-derived growth factor subunit B
133
2.1
65
0.74
P01127P01127['activation of protein kinase activity', 'activation of protein kinase B activity', 'cell chemotaxis', 'cellular response to growth factor stimulus', 'cellular response to mycophenolic acid', 'cellular response to platelet-derived growth factor stimulus', 'embryonic placenta development', 'heart development', 'interleukin-18-mediated signaling pathway', 'metanephric glomerular mesangial cell development', 'monocyte chemotaxis', 'negative regulation of gene expression', 'negative regulation of miRNA transcription', 'negative regulation of phosphatidylinositol biosynthetic process', 'negative regulation of platelet activation', 'negative regulation of protein binding', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular associated smooth muscle cell differentiation', 'paracrine signaling', 'peptidyl-serine phosphorylation', 'peptidyl-tyrosine phosphorylation', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of calcium ion import', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell-substrate adhesion', 'positive regulation of chemotaxis', 'positive regulation of cyclin-dependent protein serine/threonine kinase activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glomerular filtration', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of hyaluronan biosynthetic process', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of metanephric mesenchymal cell migration', 'positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway', 'positive regulation of miRNA transcription', 'positive regulation of mitotic nuclear division', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular associated smooth muscle cell dedifferentiation', 'positive regulation of vascular associated smooth muscle cell migration', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase C signaling', 'protein phosphorylation', 'reactive oxygen species metabolic process', 'response to wounding']['activation of protein kinase activity', 'activation of protein kinase B activity', 'cell chemotaxis', 'cellular response to growth factor stimulus', 'cellular response to mycophenolic acid', 'cellular response to platelet-derived growth factor stimulus', 'embryonic placenta development', 'heart development', 'interleukin-18-mediated signaling pathway', 'metanephric glomerular mesangial cell development', 'monocyte chemotaxis', 'negative regulation of gene expression', 'negative regulation of miRNA transcription', 'negative regulation of phosphatidylinositol biosynthetic process', 'negative regulation of platelet activation', 'negative regulation of protein binding', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular associated smooth muscle cell differentiation', 'paracrine signaling', 'peptidyl-serine phosphorylation', 'peptidyl-tyrosine phosphorylation', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of calcium ion import', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell-substrate adhesion', 'positive regulation of chemotaxis', 'positive regulation of cyclin-dependent protein serine/threonine kinase activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glomerular filtration', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of hyaluronan biosynthetic process', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of metanephric mesenchymal cell migration', 'positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway', 'positive regulation of miRNA transcription', 'positive regulation of mitotic nuclear division', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular associated smooth muscle cell dedifferentiation', 'positive regulation of vascular associated smooth muscle cell migration', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase C signaling', 'protein phosphorylation', 'reactive oxygen species metabolic process', 'response to wounding']
Peroxiredoxin-1
52
Peroxiredoxin-1
173
2.1
60
0.8
1
✔Q06830Q06830['cell population proliferation', 'cell redox homeostasis', 'erythrocyte homeostasis', 'fibroblast proliferation', 'hydrogen peroxide catabolic process', 'leukocyte activation', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'regulation of NIK/NF-kappaB signaling', 'regulation of stress-activated MAPK cascade', 'removal of superoxide radicals', 'retina homeostasis', 'skeletal system development']['cell population proliferation', 'cell redox homeostasis', 'erythrocyte homeostasis', 'fibroblast proliferation', 'hydrogen peroxide catabolic process', 'leukocyte activation', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'regulation of NIK/NF-kappaB signaling', 'regulation of stress-activated MAPK cascade', 'removal of superoxide radicals', 'retina homeostasis', 'skeletal system development']
Complement component C8 alpha chain
194
Complement component C8 gamma chain
60
2.1
61
0.79
P07357P07360['complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'immune response', 'positive regulation of immune response']['complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'positive regulation of immune response']
Prothrombin
333
Prothrombin
479
2.1
82
0.59
P19221P19221['acute-phase response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'blood coagulation', 'blood coagulation, common pathway', 'cell surface receptor signaling pathway', 'cytolysis by host of symbiont cells', 'fibrinolysis', 'negative regulation of astrocyte differentiation', 'negative regulation of cytokine production involved in inflammatory response', 'negative regulation of proteolysis', 'neutrophil-mediated killing of gram-negative bacterium', 'platelet activation', 'positive regulation of blood coagulation', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of lipid kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to nucleus', 'positive regulation of protein phosphorylation', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of release of sequestered calcium ion into cytosol', 'proteolysis', 'regulation of cell shape', 'regulation of cytosolic calcium ion concentration', 'regulation of gene expression', 'response to wounding', 'thrombin-activated receptor signaling pathway', 'zymogen activation']['acute-phase response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'blood coagulation', 'blood coagulation, common pathway', 'cell surface receptor signaling pathway', 'cytolysis by host of symbiont cells', 'fibrinolysis', 'negative regulation of astrocyte differentiation', 'negative regulation of cytokine production involved in inflammatory response', 'negative regulation of proteolysis', 'neutrophil-mediated killing of gram-negative bacterium', 'platelet activation', 'positive regulation of blood coagulation', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of lipid kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to nucleus', 'positive regulation of protein phosphorylation', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of release of sequestered calcium ion into cytosol', 'proteolysis', 'regulation of cell shape', 'regulation of cytosolic calcium ion concentration', 'regulation of gene expression', 'response to wounding', 'thrombin-activated receptor signaling pathway', 'zymogen activation']
Bone marrow stromal antigen 2
91
Bone marrow stromal antigen 2
91
2.1
49
0.99
Q10589Q10589['B cell activation', 'defense response to virus', 'innate immune response', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of intracellular transport of viral material', 'negative regulation of plasmacytoid dendritic cell cytokine production', 'negative regulation of viral genome replication', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of leukocyte proliferation', 'regulation of actin cytoskeleton organization', 'response to interferon-alpha', 'response to interferon-beta', 'response to interferon-gamma', 'response to virus']['B cell activation', 'defense response to virus', 'innate immune response', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of intracellular transport of viral material', 'negative regulation of plasmacytoid dendritic cell cytokine production', 'negative regulation of viral genome replication', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of leukocyte proliferation', 'regulation of actin cytoskeleton organization', 'response to interferon-alpha', 'response to interferon-beta', 'response to interferon-gamma', 'response to virus']
Toll-like receptor 6
712
Toll-like receptor 6
712
2.1
74
0.65
Q9Y2C9Q9Y2C9['activation of NF-kappaB-inducing kinase activity', 'cell activation', 'cellular response to amyloid-beta', 'cellular response to bacterial lipopeptide', 'cellular response to diacyl bacterial lipopeptide', 'cellular response to oxidised low-density lipoprotein particle stimulus', 'defense response to bacterium', 'detection of diacyl bacterial lipopeptide', 'immune response', 'inflammatory response', 'innate immune response', 'MyD88-dependent toll-like receptor signaling pathway', 'negative regulation of interleukin-8 production', 'negative regulation of toll-like receptor 2 signaling pathway', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of gene expression', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JUN kinase activity', 'positive regulation of macrophage activation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of NLRP3 inflammasome complex assembly', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of reactive oxygen species biosynthetic process', 'signal transduction', 'toll-like receptor 6 signaling pathway', 'toll-like receptor signaling pathway', 'toll-like receptor TLR6', 'TRIF-dependent toll-like receptor signaling pathway']['activation of NF-kappaB-inducing kinase activity', 'cell activation', 'cellular response to amyloid-beta', 'cellular response to bacterial lipopeptide', 'cellular response to diacyl bacterial lipopeptide', 'cellular response to oxidised low-density lipoprotein particle stimulus', 'defense response to bacterium', 'detection of diacyl bacterial lipopeptide', 'immune response', 'inflammatory response', 'innate immune response', 'MyD88-dependent toll-like receptor signaling pathway', 'negative regulation of interleukin-8 production', 'negative regulation of toll-like receptor 2 signaling pathway', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of gene expression', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JUN kinase activity', 'positive regulation of macrophage activation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of NLRP3 inflammasome complex assembly', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of reactive oxygen species biosynthetic process', 'signal transduction', 'toll-like receptor 6 signaling pathway', 'toll-like receptor signaling pathway', 'toll-like receptor TLR6', 'TRIF-dependent toll-like receptor signaling pathway']
Kelch-like ECH-associated protein 1
434
Kelch-like ECH-associated protein 1
434
2.1
76
0.64
Q9Z2X8Q9Z2X8['cellular response to carbohydrate stimulus', 'cellular response to interleukin-4', 'cellular response to oxidative stress', 'cytoplasmic sequestering of transcription factor', 'in utero embryonic development', 'negative regulation of gene expression', 'protein ubiquitination', 'regulation of autophagy', 'regulation of epidermal cell differentiation', 'regulation of transcription, DNA-templated', 'ubiquitin-dependent protein catabolic process']['cellular response to carbohydrate stimulus', 'cellular response to interleukin-4', 'cellular response to oxidative stress', 'cytoplasmic sequestering of transcription factor', 'in utero embryonic development', 'negative regulation of gene expression', 'protein ubiquitination', 'regulation of autophagy', 'regulation of epidermal cell differentiation', 'regulation of transcription, DNA-templated', 'ubiquitin-dependent protein catabolic process']
Lysosomal alpha-mannosidase
414
Lysosomal alpha-mannosidase
474
2.1
77
0.63
Q29451Q29451['mannose metabolic process', 'protein modification process']['mannose metabolic process', 'protein modification process']
Placenta growth factor
86
Placenta growth factor
77
2.1
69
0.7
P49763P49763['animal organ regeneration', 'cell differentiation', 'cell-cell signaling', 'cellular response to hormone stimulus', 'female pregnancy', 'induction of positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell proliferation', 'positive regulation of mast cell chemotaxis', 'positive regulation of protein phosphorylation', 'response to hypoxia', 'response to xenobiotic stimulus', 'signal transduction', 'sprouting angiogenesis', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor signaling pathway']['animal organ regeneration', 'cell differentiation', 'cell-cell signaling', 'cellular response to hormone stimulus', 'female pregnancy', 'induction of positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell proliferation', 'positive regulation of mast cell chemotaxis', 'positive regulation of protein phosphorylation', 'response to hypoxia', 'response to xenobiotic stimulus', 'signal transduction', 'sprouting angiogenesis', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor signaling pathway']
Complement C5
704
Complement C5
704
2.1
67
0.72
P01031P01031['cell surface receptor signaling pathway', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'G protein-coupled receptor signaling pathway', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']['cell surface receptor signaling pathway', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'G protein-coupled receptor signaling pathway', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']
Thioredoxin
73
Thioredoxin
62
2.1
67
0.72
P10599P10599['activation of protein kinase B activity', 'cell redox homeostasis', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of protein export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA binding', 'positive regulation of peptidyl-cysteine S-nitrosylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'response to nitric oxide', 'response to radiation']['activation of protein kinase B activity', 'cell redox homeostasis', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of protein export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA binding', 'positive regulation of peptidyl-cysteine S-nitrosylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'response to nitric oxide', 'response to radiation']
ADP-ribosylation factor GTPase-activating protein 1
96
ADP-ribosylation factor GTPase-activating protein 1
96
2.1
34
1.42
Q8N6T3Q8N6T3['protein transport', 'regulation of ARF protein signal transduction', 'regulation of endocytosis', 'vesicle-mediated transport']['protein transport', 'regulation of ARF protein signal transduction', 'regulation of endocytosis', 'vesicle-mediated transport']
PWWP domain-containing DNA repair factor 3A
501
PWWP domain-containing DNA repair factor 3A
501
2.1
46
1.05
Q2TAK8Q2TAK8['chromatin organization', 'DNA repair']['chromatin organization', 'DNA repair']
Sodium channel subunit beta-4
58
Sodium channel subunit beta-4
58
2.1
38
1.27
Q8IWT1Q8IWT1['AV node cell action potential', 'cardiac muscle cell action potential involved in contraction', 'cardiac muscle contraction', 'establishment of localization in cell', 'membrane depolarization during cardiac muscle cell action potential', 'positive regulation of sodium ion transport', 'regulation of heart rate by cardiac conduction', 'regulation of sodium ion transmembrane transporter activity', 'regulation of ventricular cardiac muscle cell membrane repolarization', 'sodium ion transmembrane transport', 'sodium ion transport']['AV node cell action potential', 'cardiac muscle cell action potential involved in contraction', 'cardiac muscle contraction', 'establishment of localization in cell', 'membrane depolarization during cardiac muscle cell action potential', 'positive regulation of sodium ion transport', 'regulation of heart rate by cardiac conduction', 'regulation of sodium ion transmembrane transporter activity', 'regulation of ventricular cardiac muscle cell membrane repolarization', 'sodium ion transmembrane transport', 'sodium ion transport']
Inhibin beta A chain
390
Inhibin beta A chain
390
2.1
68
0.71
P08476P08476['activin receptor signaling pathway', 'cell differentiation', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular response to cholesterol', 'cellular response to follicle-stimulating hormone stimulus', 'defense response', 'endodermal cell differentiation', 'erythrocyte differentiation', 'extrinsic apoptotic signaling pathway', 'eyelid development in camera-type eye', 'GABAergic neuron differentiation', 'hair follicle development', 'hematopoietic progenitor cell differentiation', 'hemoglobin biosynthetic process', 'male gonad development', 'mesodermal cell differentiation', 'multicellular organism aging', 'negative regulation of B cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of follicle-stimulating hormone secretion', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of interferon-gamma production', 'negative regulation of macrophage differentiation', 'negative regulation of phosphorylation', 'nervous system development', 'odontogenesis', 'ovarian follicle development', 'positive regulation of erythrocyte differentiation', 'positive regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'positive regulation of follicle-stimulating hormone secretion', 'positive regulation of gene expression', 'positive regulation of ovulation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein metabolic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'progesterone secretion', 'regulation of follicle-stimulating hormone secretion', 'regulation of transcription by RNA polymerase II', 'response to xenobiotic stimulus', 'roof of mouth development', 'SMAD protein signal transduction', 'striatal medium spiny neuron differentiation', 'transcription by RNA polymerase II']['activin receptor signaling pathway', 'cell differentiation', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular response to cholesterol', 'cellular response to follicle-stimulating hormone stimulus', 'defense response', 'endodermal cell differentiation', 'erythrocyte differentiation', 'extrinsic apoptotic signaling pathway', 'eyelid development in camera-type eye', 'GABAergic neuron differentiation', 'hair follicle development', 'hematopoietic progenitor cell differentiation', 'hemoglobin biosynthetic process', 'male gonad development', 'mesodermal cell differentiation', 'multicellular organism aging', 'negative regulation of B cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of follicle-stimulating hormone secretion', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of interferon-gamma production', 'negative regulation of macrophage differentiation', 'negative regulation of phosphorylation', 'nervous system development', 'odontogenesis', 'ovarian follicle development', 'positive regulation of erythrocyte differentiation', 'positive regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'positive regulation of follicle-stimulating hormone secretion', 'positive regulation of gene expression', 'positive regulation of ovulation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein metabolic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'progesterone secretion', 'regulation of follicle-stimulating hormone secretion', 'regulation of transcription by RNA polymerase II', 'response to xenobiotic stimulus', 'roof of mouth development', 'SMAD protein signal transduction', 'striatal medium spiny neuron differentiation', 'transcription by RNA polymerase II']
Membrane primary amine oxidase
748
Membrane primary amine oxidase
748
2.1
44
1.1
Q16853Q16853['amine metabolic process', 'cell adhesion', 'inflammatory response', 'negative regulation of primary amine oxidase activity', 'response to antibiotic']['amine metabolic process', 'cell adhesion', 'inflammatory response', 'negative regulation of primary amine oxidase activity', 'response to antibiotic']
Piwi-like protein 1
577
Piwi-like protein 1
577
2.1
55
0.88
Q9JMB7Q9JMB7['gene silencing by RNA', 'meiotic cell cycle', 'negative regulation of transposition', 'piRNA metabolic process', 'regulation of translation', 'spermatid development', 'spermatogenesis', 'spermatogenesis, exchange of chromosomal proteins']['gene silencing by RNA', 'meiotic cell cycle', 'negative regulation of transposition', 'piRNA metabolic process', 'regulation of translation', 'spermatid development', 'spermatogenesis', 'spermatogenesis, exchange of chromosomal proteins']
Rootletin
1152
Rootletin
1152
2.1
52
0.93
Q5TZA2Q5TZA2['cellular homeostasis', 'centriole-centriole cohesion', 'centrosome cycle', 'ciliary basal body organization', 'epithelial structure maintenance', 'establishment of localization in cell', 'establishment of organelle localization', 'photoreceptor cell maintenance', 'positive regulation of cilium assembly', 'positive regulation of protein localization to cilium', 'protein localization', 'protein localization to organelle']['cellular homeostasis', 'centriole-centriole cohesion', 'centrosome cycle', 'ciliary basal body organization', 'epithelial structure maintenance', 'establishment of localization in cell', 'establishment of organelle localization', 'photoreceptor cell maintenance', 'positive regulation of cilium assembly', 'positive regulation of protein localization to cilium', 'protein localization', 'protein localization to organelle']
Neutrophil gelatinase-associated lipocalin
107
Neutrophil gelatinase-associated lipocalin
107
2.1
40
1.21
P80188P80188['apoptotic process', 'defense response to bacterium', 'innate immune response', 'positive regulation of cold-induced thermogenesis', 'sequestering of iron ion', 'siderophore transport']['apoptotic process', 'defense response to bacterium', 'innate immune response', 'positive regulation of cold-induced thermogenesis', 'sequestering of iron ion', 'siderophore transport']
Cytoglobin
38
Cytoglobin
83
2.1
87
0.56
Q8WWM9Q8WWM9['fatty acid oxidation', 'negative regulation of collagen biosynthetic process', 'negative regulation of fibroblast migration', 'negative regulation of hepatic stellate cell activation', 'oxygen transport', 'response to hypoxia', 'response to oxidative stress']['fatty acid oxidation', 'negative regulation of collagen biosynthetic process', 'negative regulation of fibroblast migration', 'negative regulation of hepatic stellate cell activation', 'oxygen transport', 'response to hypoxia', 'response to oxidative stress']
Peroxiredoxin-4
127
Peroxiredoxin-4
248
2.1
60
0.81
1
✔O08807O08807['cell redox homeostasis', 'extracellular matrix organization', 'male gonad development', 'negative regulation of male germ cell proliferation', 'peptidyl-proline hydroxylation to 4-hydroxy-L-proline', 'protein maturation by protein folding', 'reactive oxygen species metabolic process', 'response to oxidative stress', 'spermatogenesis']['cell redox homeostasis', 'extracellular matrix organization', 'male gonad development', 'negative regulation of male germ cell proliferation', 'peptidyl-proline hydroxylation to 4-hydroxy-L-proline', 'protein maturation by protein folding', 'reactive oxygen species metabolic process', 'response to oxidative stress', 'spermatogenesis']
Cadherin-23
863
Cadherin-23
863
2.1
92
0.53
Q99PF4Q99PF4['auditory receptor cell stereocilium organization', 'calcium ion transport', 'calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules', 'cell adhesion', 'cell-cell adhesion via plasma-membrane adhesion molecules', 'equilibrioception', 'homophilic cell adhesion via plasma membrane adhesion molecules', 'inner ear auditory receptor cell differentiation', 'inner ear development', 'inner ear morphogenesis', 'inner ear receptor cell stereocilium organization', 'locomotory behavior', 'photoreceptor cell maintenance', 'post-embryonic animal organ morphogenesis', 'regulation of cytosolic calcium ion concentration', 'sensory perception of light stimulus', 'sensory perception of sound']['auditory receptor cell stereocilium organization', 'calcium ion transport', 'calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules', 'cell adhesion', 'cell-cell adhesion via plasma-membrane adhesion molecules', 'equilibrioception', 'homophilic cell adhesion via plasma membrane adhesion molecules', 'inner ear auditory receptor cell differentiation', 'inner ear development', 'inner ear morphogenesis', 'inner ear receptor cell stereocilium organization', 'locomotory behavior', 'photoreceptor cell maintenance', 'post-embryonic animal organ morphogenesis', 'regulation of cytosolic calcium ion concentration', 'sensory perception of light stimulus', 'sensory perception of sound']
SH3 and multiple ankyrin repeat domains protein 3
41
SH3 and multiple ankyrin repeat domains protein 3
41
2.1
57
0.85
Q9BYB0Q9BYB0['adult behavior', 'AMPA glutamate receptor clustering', 'brain morphogenesis', 'dendritic spine morphogenesis', 'guanylate kinase-associated protein clustering', 'learning', 'MAPK cascade', 'memory', 'negative regulation of actin filament bundle assembly', 'negative regulation of cell volume', 'NMDA glutamate receptor clustering', 'positive regulation of AMPA receptor activity', 'positive regulation of dendritic spine development', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of glutamate receptor signaling pathway', 'positive regulation of long-term neuronal synaptic plasticity', 'positive regulation of long-term synaptic potentiation', 'positive regulation of synapse structural plasticity', 'positive regulation of synaptic transmission, glutamatergic', 'postsynaptic density assembly', 'regulation of dendritic spine morphogenesis', 'regulation of long-term synaptic depression', 'regulation of long-term synaptic potentiation', 'social behavior', 'striatal medium spiny neuron differentiation', 'synapse assembly', 'vocal learning', 'vocalization behavior']['adult behavior', 'AMPA glutamate receptor clustering', 'brain morphogenesis', 'dendritic spine morphogenesis', 'guanylate kinase-associated protein clustering', 'learning', 'MAPK cascade', 'memory', 'negative regulation of actin filament bundle assembly', 'negative regulation of cell volume', 'NMDA glutamate receptor clustering', 'positive regulation of AMPA receptor activity', 'positive regulation of dendritic spine development', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of glutamate receptor signaling pathway', 'positive regulation of long-term neuronal synaptic plasticity', 'positive regulation of long-term synaptic potentiation', 'positive regulation of synapse structural plasticity', 'positive regulation of synaptic transmission, glutamatergic', 'postsynaptic density assembly', 'regulation of dendritic spine morphogenesis', 'regulation of long-term synaptic depression', 'regulation of long-term synaptic potentiation', 'social behavior', 'striatal medium spiny neuron differentiation', 'synapse assembly', 'vocal learning', 'vocalization behavior']
Myeloid cell surface antigen CD33
36
Myeloid cell surface antigen CD33
36
2.1
72
0.67
P20138P20138['cell adhesion', 'cell-cell adhesion', 'cell-cell signaling', 'immune response-inhibiting signal transduction', 'negative regulation of calcium ion transport', 'negative regulation of cell population proliferation', 'negative regulation of interleukin-1 beta production', 'negative regulation of interleukin-8 production', 'negative regulation of monocyte activation', 'negative regulation of tumor necrosis factor production', 'positive regulation of protein secretion', 'positive regulation of protein tyrosine phosphatase activity', 'signal transduction']['cell adhesion', 'cell-cell adhesion', 'cell-cell signaling', 'immune response-inhibiting signal transduction', 'negative regulation of calcium ion transport', 'negative regulation of cell population proliferation', 'negative regulation of interleukin-1 beta production', 'negative regulation of interleukin-8 production', 'negative regulation of monocyte activation', 'negative regulation of tumor necrosis factor production', 'positive regulation of protein secretion', 'positive regulation of protein tyrosine phosphatase activity', 'signal transduction']
Growth/differentiation factor 8
340
Growth/differentiation factor 8
340
2.1
80
0.61
O08689O08689['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
Histone deacetylase complex subunit SAP18
26
Histone deacetylase complex subunit SAP18
26
2.1
41
1.18
O55128O55128['mRNA processing', 'negative regulation of mRNA splicing, via spliceosome', 'negative regulation of transcription, DNA-templated', 'positive regulation of apoptotic process', 'regulation of alternative mRNA splicing, via spliceosome', 'regulation of transcription, DNA-templated', 'RNA splicing']['mRNA processing', 'negative regulation of mRNA splicing, via spliceosome', 'negative regulation of transcription, DNA-templated', 'positive regulation of apoptotic process', 'regulation of alternative mRNA splicing, via spliceosome', 'regulation of transcription, DNA-templated', 'RNA splicing']
Fibroblast growth factor 2
211
Fibroblast growth factor 2
211
2.0
74
0.66
P09038P09038['aging', 'angiogenesis involved in coronary vascular morphogenesis', 'animal organ morphogenesis', 'branching involved in ureteric bud morphogenesis', 'canonical Wnt signaling pathway', 'cell differentiation', 'cell migration involved in sprouting angiogenesis', 'cellular response to mechanical stimulus', 'cerebellar granule cell precursor proliferation', 'chemotaxis', 'chondroblast differentiation', 'corticotropin hormone secreting cell differentiation', 'embryo development ending in birth or egg hatching', 'embryonic morphogenesis', 'endothelial cell proliferation', 'ERK1 and ERK2 cascade', 'fibroblast growth factor receptor signaling pathway', 'glial cell differentiation', 'growth factor dependent regulation of skeletal muscle satellite cell proliferation', 'hyaluronan catabolic process', 'inner ear auditory receptor cell differentiation', 'inositol phosphate biosynthetic process', 'lung development', 'lymphatic endothelial cell migration', 'mammary gland epithelial cell differentiation', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell death', 'negative regulation of fibroblast growth factor receptor signaling pathway', 'negative regulation of fibroblast migration', 'negative regulation of gene expression', 'negative regulation of stem cell proliferation', 'negative regulation of wound healing', 'nervous system development', 'neuroblast proliferation', 'organ induction', 'osteoblast differentiation', 'paracrine signaling', 'phosphatidylinositol biosynthetic process', 'positive regulation of angiogenesis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cell division', 'positive regulation of cell fate specification', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cerebellar granule cell precursor proliferation', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis', 'positive regulation of endothelial cell chemotaxis to fibroblast growth factor', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of inner ear auditory receptor cell differentiation', 'positive regulation of lens fiber cell differentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of miRNA transcription', 'positive regulation of neuroblast proliferation', 'positive regulation of neuroepithelial cell differentiation', 'positive regulation of osteoblast differentiation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phospholipase C activity', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of sprouting angiogenesis', 'positive regulation of stem cell differentiation', 'positive regulation of stem cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular associated smooth muscle cell proliferation', 'positive regulation of vascular endothelial cell proliferation', 'protein kinase B signaling', 'Ras protein signal transduction', 'regulation of angiogenesis', 'regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'regulation of cell cycle', 'regulation of cell migration', 'regulation of cell migration involved in sprouting angiogenesis', 'regulation of endothelial cell chemotaxis to fibroblast growth factor', 'regulation of retinal cell programmed cell death', 'release of sequestered calcium ion into cytosol', 'response to axon injury', 'signal transduction', 'stem cell development', 'stem cell proliferation', 'substantia nigra development', 'thyroid-stimulating hormone-secreting cell differentiation', 'transcription by RNA polymerase II', 'wound healing']['aging', 'angiogenesis involved in coronary vascular morphogenesis', 'animal organ morphogenesis', 'branching involved in ureteric bud morphogenesis', 'canonical Wnt signaling pathway', 'cell differentiation', 'cell migration involved in sprouting angiogenesis', 'cellular response to mechanical stimulus', 'cerebellar granule cell precursor proliferation', 'chemotaxis', 'chondroblast differentiation', 'corticotropin hormone secreting cell differentiation', 'embryo development ending in birth or egg hatching', 'embryonic morphogenesis', 'endothelial cell proliferation', 'ERK1 and ERK2 cascade', 'fibroblast growth factor receptor signaling pathway', 'glial cell differentiation', 'growth factor dependent regulation of skeletal muscle satellite cell proliferation', 'hyaluronan catabolic process', 'inner ear auditory receptor cell differentiation', 'inositol phosphate biosynthetic process', 'lung development', 'lymphatic endothelial cell migration', 'mammary gland epithelial cell differentiation', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell death', 'negative regulation of fibroblast growth factor receptor signaling pathway', 'negative regulation of fibroblast migration', 'negative regulation of gene expression', 'negative regulation of stem cell proliferation', 'negative regulation of wound healing', 'nervous system development', 'neuroblast proliferation', 'organ induction', 'osteoblast differentiation', 'paracrine signaling', 'phosphatidylinositol biosynthetic process', 'positive regulation of angiogenesis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cell division', 'positive regulation of cell fate specification', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cerebellar granule cell precursor proliferation', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis', 'positive regulation of endothelial cell chemotaxis to fibroblast growth factor', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of inner ear auditory receptor cell differentiation', 'positive regulation of lens fiber cell differentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of miRNA transcription', 'positive regulation of neuroblast proliferation', 'positive regulation of neuroepithelial cell differentiation', 'positive regulation of osteoblast differentiation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phospholipase C activity', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of sprouting angiogenesis', 'positive regulation of stem cell differentiation', 'positive regulation of stem cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular associated smooth muscle cell proliferation', 'positive regulation of vascular endothelial cell proliferation', 'protein kinase B signaling', 'Ras protein signal transduction', 'regulation of angiogenesis', 'regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'regulation of cell cycle', 'regulation of cell migration', 'regulation of cell migration involved in sprouting angiogenesis', 'regulation of endothelial cell chemotaxis to fibroblast growth factor', 'regulation of retinal cell programmed cell death', 'release of sequestered calcium ion into cytosol', 'response to axon injury', 'signal transduction', 'stem cell development', 'stem cell proliferation', 'substantia nigra development', 'thyroid-stimulating hormone-secreting cell differentiation', 'transcription by RNA polymerase II', 'wound healing']
Alpha-2-macroglobulin
431
Alpha-2-macroglobulin
278
2.0
41
1.19
P01023P01023['acute inflammatory response to antigenic stimulus', 'acute-phase response', 'embryonic liver development', 'luteinization', 'negative regulation of complement activation, lectin pathway', 'response to carbon dioxide', 'response to glucocorticoid', 'response to nutrient', 'response to prostaglandin E', 'stem cell differentiation']['acute inflammatory response to antigenic stimulus', 'acute-phase response', 'embryonic liver development', 'luteinization', 'negative regulation of complement activation, lectin pathway', 'response to carbon dioxide', 'response to glucocorticoid', 'response to nutrient', 'response to prostaglandin E', 'stem cell differentiation']
Regulation of nuclear pre-mRNA domain-containing protein 1B
100
Regulation of nuclear pre-mRNA domain-containing protein 1B
100
2.0
73
0.67
Q9NQG5Q9NQG5['dephosphorylation of RNA polymerase II C-terminal domain', "mRNA 3'-end processing", 'positive regulation of cell population proliferation', 'positive regulation of transcription by RNA polymerase II', 'regulation of cell cycle process']['dephosphorylation of RNA polymerase II C-terminal domain', "mRNA 3'-end processing", 'positive regulation of cell population proliferation', 'positive regulation of transcription by RNA polymerase II', 'regulation of cell cycle process']
Transmembrane protease serine 13
317
Transmembrane protease serine 13
434
2.1
80
0.61
Q9BYE2Q9BYE2['proteolysis']['proteolysis']
Serine/threonine-protein kinase 10
206
Serine/threonine-protein kinase 10
206
2.1
61
0.8
O94804O94804['cell cycle', 'lymphocyte aggregation', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of lymphocyte migration']['cell cycle', 'lymphocyte aggregation', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of lymphocyte migration']
Mannan-binding lectin serine protease 2
434
Mannan-binding lectin serine protease 2
552
2.1
75
0.65
O00187O00187['cell surface pattern recognition receptor signaling pathway', 'complement activation, classical pathway', 'complement activation, lectin pathway', 'positive regulation of opsonization', 'proteolysis']['cell surface pattern recognition receptor signaling pathway', 'complement activation, classical pathway', 'complement activation, lectin pathway', 'positive regulation of opsonization', 'proteolysis']
Peroxiredoxin-1
83
Peroxiredoxin-1
83
2.1
84
0.58
Q63716Q63716['cell population proliferation', 'cell redox homeostasis', 'erythrocyte homeostasis', 'hydrogen peroxide catabolic process', 'leukocyte activation', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'regulation of NIK/NF-kappaB signaling', 'regulation of stress-activated MAPK cascade', 'removal of superoxide radicals', 'response to oxidative stress', 'response to reactive oxygen species']['cell population proliferation', 'cell redox homeostasis', 'erythrocyte homeostasis', 'hydrogen peroxide catabolic process', 'leukocyte activation', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'regulation of NIK/NF-kappaB signaling', 'regulation of stress-activated MAPK cascade', 'removal of superoxide radicals', 'response to oxidative stress', 'response to reactive oxygen species']
Fibrinogen alpha chain
180
Fibrinogen gamma chain
161
2.1
80
0.61
P02671P02679['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Prorelaxin H2
172
Prorelaxin H2
35
2.1
53
0.92
P04090P04090['female pregnancy', 'positive regulation of angiogenesis', 'positive regulation of gene expression', 'regulation of catalytic activity']['female pregnancy', 'positive regulation of angiogenesis', 'positive regulation of gene expression', 'regulation of catalytic activity']
DNA primase large subunit
449
DNA primase large subunit
449
2.1
84
0.58
P49643P49643['DNA replication initiation', 'DNA replication, synthesis of RNA primer', 'positive regulation of DNA primase activity']['DNA replication initiation', 'DNA replication, synthesis of RNA primer', 'positive regulation of DNA primase activity']
Mucin-2
1088
Mucin-2
1088
2.1
82
0.59
Q02817Q02817['maintenance of gastrointestinal epithelium']['maintenance of gastrointestinal epithelium']
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
106
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
106
2.1
96
0.51
Q9H3H5Q9H3H5['dolichol metabolic process', 'dolichol-linked oligosaccharide biosynthetic process', 'protein N-linked glycosylation', 'UDP-N-acetylglucosamine metabolic process']['dolichol metabolic process', 'dolichol-linked oligosaccharide biosynthetic process', 'protein N-linked glycosylation', 'UDP-N-acetylglucosamine metabolic process']
Gamma-crystallin S
25
Gamma-crystallin S
25
2.1
73
0.66
O35486O35486['lens development in camera-type eye', 'morphogenesis of an epithelium', 'visual perception']['lens development in camera-type eye', 'morphogenesis of an epithelium', 'visual perception']
Abasic site processing protein HMCES
39
Abasic site processing protein HMCES
39
2.1
72
0.67
Q96FZ2Q96FZ2['cellular response to DNA damage stimulus', 'double-strand break repair via alternative nonhomologous end joining', 'positive regulation of isotype switching', 'protein-DNA covalent cross-linking', 'proteolysis']['cellular response to DNA damage stimulus', 'double-strand break repair via alternative nonhomologous end joining', 'positive regulation of isotype switching', 'protein-DNA covalent cross-linking', 'proteolysis']
Mitogen-activated protein kinase kinase kinase 9
421
Mitogen-activated protein kinase kinase kinase 9
421
2.1
60
0.81
P80192P80192['apoptotic process', 'positive regulation of apoptotic process', 'protein autophosphorylation', 'protein phosphorylation']['apoptotic process', 'positive regulation of apoptotic process', 'protein autophosphorylation', 'protein phosphorylation']
UBX domain-containing protein 7
478
UBX domain-containing protein 7
478
2.1
67
0.73
O94888O94888['proteasome-mediated ubiquitin-dependent protein catabolic process']['proteasome-mediated ubiquitin-dependent protein catabolic process']
N-acetyltransferase ESCO1
757
N-acetyltransferase ESCO1
757
2.0
84
0.58
Q5FWF5Q5FWF5['mitotic sister chromatid cohesion', 'peptidyl-lysine acetylation', 'post-translational protein acetylation', 'regulation of DNA replication']['mitotic sister chromatid cohesion', 'peptidyl-lysine acetylation', 'post-translational protein acetylation', 'regulation of DNA replication']
Interleukin-5
62
Interleukin-5
104
2.0
68
0.72
P04401P04401['cytokine-mediated signaling pathway', 'immune response', 'inflammatory response', 'peptidyl-tyrosine phosphorylation', 'positive regulation of B cell proliferation', 'positive regulation of cell population proliferation', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of eosinophil differentiation', 'positive regulation of immunoglobulin production', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of podosome assembly', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of transcription, DNA-templated']['cytokine-mediated signaling pathway', 'immune response', 'inflammatory response', 'peptidyl-tyrosine phosphorylation', 'positive regulation of B cell proliferation', 'positive regulation of cell population proliferation', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of eosinophil differentiation', 'positive regulation of immunoglobulin production', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of podosome assembly', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of transcription, DNA-templated']
Immunoglobulin lambda-1 light chain
215
Immunoglobulin lambda-1 light chain
215
2.0
35
1.39
P0DOX8P0DOX8['adaptive immune response']['adaptive immune response']
Spindle and kinetochore-associated protein 3
20
Spindle and kinetochore-associated protein 3
20
2.0
61
0.8
Q8IX90Q8IX90['cell division', 'chromosome segregation', 'mitotic cell cycle', 'regulation of microtubule polymerization or depolymerization']['cell division', 'chromosome segregation', 'mitotic cell cycle', 'regulation of microtubule polymerization or depolymerization']
Thioredoxin
62
Thioredoxin
62
2.0
67
0.73
P10599P10599['activation of protein kinase B activity', 'cell redox homeostasis', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of protein export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA binding', 'positive regulation of peptidyl-cysteine S-nitrosylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'response to nitric oxide', 'response to radiation']['activation of protein kinase B activity', 'cell redox homeostasis', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of protein export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA binding', 'positive regulation of peptidyl-cysteine S-nitrosylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'response to nitric oxide', 'response to radiation']
Complement C4-A
567
Complement C4-A
820
2.0
77
0.63
P0C0L4P0C0L4['complement activation', 'complement activation, classical pathway', 'inflammatory response', 'innate immune response', 'positive regulation of apoptotic cell clearance', 'positive regulation of immune response', 'positive regulation of opsonization']['complement activation', 'complement activation, classical pathway', 'inflammatory response', 'innate immune response', 'positive regulation of apoptotic cell clearance', 'positive regulation of immune response', 'positive regulation of opsonization']
Zinc fingers and homeoboxes protein 2
494
Zinc fingers and homeoboxes protein 2
494
2.0
65
0.75
Q9Y6X8Q9Y6X8['mRNA catabolic process', 'negative regulation of neuron differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'regulation of transcription by RNA polymerase II', 'retinal bipolar neuron differentiation', 'somatic stem cell population maintenance']['mRNA catabolic process', 'negative regulation of neuron differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'regulation of transcription by RNA polymerase II', 'retinal bipolar neuron differentiation', 'somatic stem cell population maintenance']
E3 SUMO-protein ligase RanBP2
3071
E3 SUMO-protein ligase RanBP2
3213
2.0
75
0.65
P49792P49792['centrosome localization', 'mRNA transport', 'NLS-bearing protein import into nucleus', 'nuclear export', 'nucleocytoplasmic transport', 'positive regulation of glucokinase activity', 'protein folding', 'protein peptidyl-prolyl isomerization', 'protein sumoylation', 'regulation of gluconeogenesis']['centrosome localization', 'mRNA transport', 'NLS-bearing protein import into nucleus', 'nuclear export', 'nucleocytoplasmic transport', 'positive regulation of glucokinase activity', 'protein folding', 'protein peptidyl-prolyl isomerization', 'protein sumoylation', 'regulation of gluconeogenesis']
Trypsin
15
Trypsin
145
2.0
64
0.76
P00761P00761['digestion', 'proteolysis']['digestion', 'proteolysis']
Beta-hexosaminidase subunit alpha
58
Beta-hexosaminidase subunit alpha
104
2.0
68
0.72
P06865P06865['adult walking behavior', 'carbohydrate metabolic process', 'cell morphogenesis involved in neuron differentiation', 'ganglioside catabolic process', 'glycosaminoglycan biosynthetic process', 'glycosaminoglycan metabolic process', 'lipid storage', 'lysosome organization', 'maintenance of location in cell', 'myelination', 'neuromuscular process controlling balance', 'neuromuscular process controlling posture', 'sensory perception of sound', 'sexual reproduction', 'skeletal system development', 'SMAD protein signal transduction']['adult walking behavior', 'carbohydrate metabolic process', 'cell morphogenesis involved in neuron differentiation', 'ganglioside catabolic process', 'glycosaminoglycan biosynthetic process', 'glycosaminoglycan metabolic process', 'lipid storage', 'lysosome organization', 'maintenance of location in cell', 'myelination', 'neuromuscular process controlling balance', 'neuromuscular process controlling posture', 'sensory perception of sound', 'sexual reproduction', 'skeletal system development', 'SMAD protein signal transduction']
Vascular endothelial growth factor A
86
Vascular endothelial growth factor A
77
2.0
80
0.61
Q96NW5Q96NW5['activation of protein kinase activity', 'angiogenesis', 'artery morphogenesis', 'basophil chemotaxis', 'branching involved in blood vessel morphogenesis', 'camera-type eye morphogenesis', 'cardiac muscle cell development', 'cardiac vascular smooth muscle cell development', 'cell maturation', 'cell migration involved in sprouting angiogenesis', 'cellular response to hypoxia', 'cellular response to vascular endothelial growth factor stimulus', 'cellular stress response to acid chemical', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'coronary vein morphogenesis', 'dopaminergic neuron differentiation', 'endothelial cell chemotaxis', 'epithelial cell differentiation', 'eye photoreceptor cell development', 'heart morphogenesis', 'in utero embryonic development', 'induction of positive chemotaxis', 'kidney development', 'lactation', 'lung development', 'lymph vessel morphogenesis', 'macrophage differentiation', 'mammary gland alveolus development', 'mesoderm development', 'monocyte differentiation', 'motor neuron migration', 'negative regulation of adherens junction organization', 'negative regulation of apoptotic process', 'negative regulation of blood-brain barrier permeability', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of establishment of endothelial barrier', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'outflow tract morphogenesis', 'ovarian follicle development', 'positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell migration by vascular endothelial growth factor signaling pathway', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway', 'positive regulation of cold-induced thermogenesis', 'positive regulation of CREB transcription factor activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of histone deacetylase activity', 'positive regulation of leukocyte migration', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of neuroblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of positive chemotaxis', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C signaling', 'positive regulation of protein kinase D signaling', 'positive regulation of protein localization to early endosome', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor internalization', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of trophoblast cell migration', 'positive regulation of vascular permeability', 'post-embryonic camera-type eye development', 'primitive erythrocyte differentiation', 'regulation of cell shape', 'regulation of nitric oxide mediated signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of transcription by RNA polymerase II', 'response to hypoxia', 'sprouting angiogenesis', 'surfactant homeostasis', 'tube formation', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway']['activation of protein kinase activity', 'angiogenesis', 'artery morphogenesis', 'basophil chemotaxis', 'branching involved in blood vessel morphogenesis', 'camera-type eye morphogenesis', 'cardiac muscle cell development', 'cardiac vascular smooth muscle cell development', 'cell maturation', 'cell migration involved in sprouting angiogenesis', 'cellular response to hypoxia', 'cellular response to vascular endothelial growth factor stimulus', 'cellular stress response to acid chemical', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'coronary vein morphogenesis', 'dopaminergic neuron differentiation', 'endothelial cell chemotaxis', 'epithelial cell differentiation', 'eye photoreceptor cell development', 'heart morphogenesis', 'in utero embryonic development', 'induction of positive chemotaxis', 'kidney development', 'lactation', 'lung development', 'lymph vessel morphogenesis', 'macrophage differentiation', 'mammary gland alveolus development', 'mesoderm development', 'monocyte differentiation', 'motor neuron migration', 'negative regulation of adherens junction organization', 'negative regulation of apoptotic process', 'negative regulation of blood-brain barrier permeability', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of establishment of endothelial barrier', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'outflow tract morphogenesis', 'ovarian follicle development', 'positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell migration by vascular endothelial growth factor signaling pathway', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway', 'positive regulation of cold-induced thermogenesis', 'positive regulation of CREB transcription factor activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of histone deacetylase activity', 'positive regulation of leukocyte migration', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of neuroblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of positive chemotaxis', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C signaling', 'positive regulation of protein kinase D signaling', 'positive regulation of protein localization to early endosome', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor internalization', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of trophoblast cell migration', 'positive regulation of vascular permeability', 'post-embryonic camera-type eye development', 'primitive erythrocyte differentiation', 'regulation of cell shape', 'regulation of nitric oxide mediated signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of transcription by RNA polymerase II', 'response to hypoxia', 'sprouting angiogenesis', 'surfactant homeostasis', 'tube formation', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway']
Bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7
47
Bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7
47
2.0
82
0.59
P0C872P0C872['protein hydroxylation', 'proteolysis']['protein hydroxylation', 'proteolysis']
Set1/Ash2 histone methyltransferase complex subunit ASH2
581
Set1/Ash2 histone methyltransferase complex subunit ASH2
581
2.0
48
1.02
Q9UBL3Q9UBL3['cellular response to DNA damage stimulus', 'chromatin organization', 'hemopoiesis', 'histone H3-K4 methylation', 'positive regulation of cell population proliferation', 'positive regulation of transcription by RNA polymerase II', 'response to estrogen']['cellular response to DNA damage stimulus', 'chromatin organization', 'hemopoiesis', 'histone H3-K4 methylation', 'positive regulation of cell population proliferation', 'positive regulation of transcription by RNA polymerase II', 'response to estrogen']
Ubiquitin carboxyl-terminal hydrolase 7
576
Ubiquitin carboxyl-terminal hydrolase 7
576
2.0
76
0.64
Q93009Q93009['histone H2B conserved C-terminal lysine deubiquitination', 'maintenance of DNA methylation', 'monoubiquitinated protein deubiquitination', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of DNA demethylation', 'protein deubiquitination', 'protein K63-linked deubiquitination', 'protein stabilization', 'protein ubiquitination', 'regulation of circadian rhythm', 'regulation of DNA-binding transcription factor activity', 'regulation of gluconeogenesis', 'regulation of protein stability', 'regulation of retrograde transport, endosome to Golgi', 'regulation of signal transduction by p53 class mediator', 'regulation of telomere capping', 'rhythmic process', 'transcription-coupled nucleotide-excision repair', 'ubiquitin-dependent protein catabolic process']['histone H2B conserved C-terminal lysine deubiquitination', 'maintenance of DNA methylation', 'monoubiquitinated protein deubiquitination', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of DNA demethylation', 'protein deubiquitination', 'protein K63-linked deubiquitination', 'protein stabilization', 'protein ubiquitination', 'regulation of circadian rhythm', 'regulation of DNA-binding transcription factor activity', 'regulation of gluconeogenesis', 'regulation of protein stability', 'regulation of retrograde transport, endosome to Golgi', 'regulation of signal transduction by p53 class mediator', 'regulation of telomere capping', 'rhythmic process', 'transcription-coupled nucleotide-excision repair', 'ubiquitin-dependent protein catabolic process']
Nitric oxide synthase, endothelial
99
Nitric oxide synthase, endothelial
94
3.7
74
0.36
P29474P29474['angiogenesis', 'aortic valve morphogenesis', 'arginine catabolic process', 'blood vessel diameter maintenance', 'blood vessel remodeling', 'calcium ion transport', 'cell redox homeostasis', 'endocardial cushion morphogenesis', 'endothelial cell migration', 'establishment of localization in cell', 'homeostasis of number of cells within a tissue', 'in utero embryonic development', 'lipopolysaccharide-mediated signaling pathway', 'lung development', 'mitochondrion organization', 'negative regulation of biomineral tissue development', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of cell population proliferation', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrolase activity', 'negative regulation of muscle hyperplasia', 'negative regulation of platelet activation', 'negative regulation of potassium ion transport', 'negative regulation of smooth muscle cell proliferation', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'ovulation from ovarian follicle', 'positive regulation of angiogenesis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of gene expression', 'positive regulation of guanylate cyclase activity', 'positive regulation of Notch signaling pathway', 'potassium ion transport', 'pulmonary valve morphogenesis', 'regulation of blood pressure', 'regulation of nervous system process', 'regulation of sodium ion transport', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of the force of heart contraction by chemical signal', 'removal of superoxide radicals', 'response to fluid shear stress', 'response to heat', 'response to hormone', 'response to lipopolysaccharide', 'smooth muscle hyperplasia', 'vasodilation', 'ventricular septum morphogenesis']['angiogenesis', 'aortic valve morphogenesis', 'arginine catabolic process', 'blood vessel diameter maintenance', 'blood vessel remodeling', 'calcium ion transport', 'cell redox homeostasis', 'endocardial cushion morphogenesis', 'endothelial cell migration', 'establishment of localization in cell', 'homeostasis of number of cells within a tissue', 'in utero embryonic development', 'lipopolysaccharide-mediated signaling pathway', 'lung development', 'mitochondrion organization', 'negative regulation of biomineral tissue development', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of cell population proliferation', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrolase activity', 'negative regulation of muscle hyperplasia', 'negative regulation of platelet activation', 'negative regulation of potassium ion transport', 'negative regulation of smooth muscle cell proliferation', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'ovulation from ovarian follicle', 'positive regulation of angiogenesis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of gene expression', 'positive regulation of guanylate cyclase activity', 'positive regulation of Notch signaling pathway', 'potassium ion transport', 'pulmonary valve morphogenesis', 'regulation of blood pressure', 'regulation of nervous system process', 'regulation of sodium ion transport', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of the force of heart contraction by chemical signal', 'removal of superoxide radicals', 'response to fluid shear stress', 'response to heat', 'response to hormone', 'response to lipopolysaccharide', 'smooth muscle hyperplasia', 'vasodilation', 'ventricular septum morphogenesis']
Nitric oxide synthase, brain
331
Nitric oxide synthase, brain
331
3.7
83
0.33
P29476P29476['aging', 'arginine catabolic process', 'behavioral response to cocaine', 'brain development', 'cellular response to epinephrine stimulus', 'cellular response to growth factor stimulus', 'cellular response to mechanical stimulus', 'establishment of protein localization', 'female pregnancy', 'multicellular organismal response to stress', 'muscle contraction', 'negative regulation of apoptotic process', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of cell population proliferation', 'negative regulation of cytosolic calcium ion concentration', 'negative regulation of heart contraction', 'negative regulation of hepatic stellate cell contraction', 'negative regulation of hydrolase activity', 'negative regulation of insulin secretion', 'negative regulation of iron ion transmembrane transport', 'negative regulation of neuron apoptotic process', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of potassium ion transport', 'negative regulation of serotonin uptake', 'negative regulation of vasoconstriction', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'positive regulation of guanylate cyclase activity', 'positive regulation of histone acetylation', 'positive regulation of long-term synaptic potentiation', 'positive regulation of neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of sodium ion transmembrane transport', 'positive regulation of the force of heart contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of heart contraction', 'regulation of neurogenesis', 'regulation of sensory perception of pain', 'regulation of sodium ion transport', 'response to activity', 'response to estrogen', 'response to ethanol', 'response to heat', 'response to hormone', 'response to hypoxia', 'response to lead ion', 'response to lipopolysaccharide', 'response to nicotine', 'response to nitric oxide', 'response to nutrient levels', 'response to organic cyclic compound', 'response to organonitrogen compound', 'response to peptide hormone', 'response to vitamin E', 'retrograde trans-synaptic signaling by nitric oxide', 'striated muscle contraction', 'synaptic signaling by nitric oxide', 'vasodilation', 'xenobiotic catabolic process']['aging', 'arginine catabolic process', 'behavioral response to cocaine', 'brain development', 'cellular response to epinephrine stimulus', 'cellular response to growth factor stimulus', 'cellular response to mechanical stimulus', 'establishment of protein localization', 'female pregnancy', 'multicellular organismal response to stress', 'muscle contraction', 'negative regulation of apoptotic process', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of cell population proliferation', 'negative regulation of cytosolic calcium ion concentration', 'negative regulation of heart contraction', 'negative regulation of hepatic stellate cell contraction', 'negative regulation of hydrolase activity', 'negative regulation of insulin secretion', 'negative regulation of iron ion transmembrane transport', 'negative regulation of neuron apoptotic process', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of potassium ion transport', 'negative regulation of serotonin uptake', 'negative regulation of vasoconstriction', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'positive regulation of guanylate cyclase activity', 'positive regulation of histone acetylation', 'positive regulation of long-term synaptic potentiation', 'positive regulation of neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of sodium ion transmembrane transport', 'positive regulation of the force of heart contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of heart contraction', 'regulation of neurogenesis', 'regulation of sensory perception of pain', 'regulation of sodium ion transport', 'response to activity', 'response to estrogen', 'response to ethanol', 'response to heat', 'response to hormone', 'response to hypoxia', 'response to lead ion', 'response to lipopolysaccharide', 'response to nicotine', 'response to nitric oxide', 'response to nutrient levels', 'response to organic cyclic compound', 'response to organonitrogen compound', 'response to peptide hormone', 'response to vitamin E', 'retrograde trans-synaptic signaling by nitric oxide', 'striated muscle contraction', 'synaptic signaling by nitric oxide', 'vasodilation', 'xenobiotic catabolic process']
Nitric oxide synthase, brain
331
Nitric oxide synthase, brain
326
3.7
74
0.37
P29476P29476['aging', 'arginine catabolic process', 'behavioral response to cocaine', 'brain development', 'cellular response to epinephrine stimulus', 'cellular response to growth factor stimulus', 'cellular response to mechanical stimulus', 'establishment of protein localization', 'female pregnancy', 'multicellular organismal response to stress', 'muscle contraction', 'negative regulation of apoptotic process', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of cell population proliferation', 'negative regulation of cytosolic calcium ion concentration', 'negative regulation of heart contraction', 'negative regulation of hepatic stellate cell contraction', 'negative regulation of hydrolase activity', 'negative regulation of insulin secretion', 'negative regulation of iron ion transmembrane transport', 'negative regulation of neuron apoptotic process', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of potassium ion transport', 'negative regulation of serotonin uptake', 'negative regulation of vasoconstriction', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'positive regulation of guanylate cyclase activity', 'positive regulation of histone acetylation', 'positive regulation of long-term synaptic potentiation', 'positive regulation of neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of sodium ion transmembrane transport', 'positive regulation of the force of heart contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of heart contraction', 'regulation of neurogenesis', 'regulation of sensory perception of pain', 'regulation of sodium ion transport', 'response to activity', 'response to estrogen', 'response to ethanol', 'response to heat', 'response to hormone', 'response to hypoxia', 'response to lead ion', 'response to lipopolysaccharide', 'response to nicotine', 'response to nitric oxide', 'response to nutrient levels', 'response to organic cyclic compound', 'response to organonitrogen compound', 'response to peptide hormone', 'response to vitamin E', 'retrograde trans-synaptic signaling by nitric oxide', 'striated muscle contraction', 'synaptic signaling by nitric oxide', 'vasodilation', 'xenobiotic catabolic process']['aging', 'arginine catabolic process', 'behavioral response to cocaine', 'brain development', 'cellular response to epinephrine stimulus', 'cellular response to growth factor stimulus', 'cellular response to mechanical stimulus', 'establishment of protein localization', 'female pregnancy', 'multicellular organismal response to stress', 'muscle contraction', 'negative regulation of apoptotic process', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of cell population proliferation', 'negative regulation of cytosolic calcium ion concentration', 'negative regulation of heart contraction', 'negative regulation of hepatic stellate cell contraction', 'negative regulation of hydrolase activity', 'negative regulation of insulin secretion', 'negative regulation of iron ion transmembrane transport', 'negative regulation of neuron apoptotic process', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of potassium ion transport', 'negative regulation of serotonin uptake', 'negative regulation of vasoconstriction', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'positive regulation of guanylate cyclase activity', 'positive regulation of histone acetylation', 'positive regulation of long-term synaptic potentiation', 'positive regulation of neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of sodium ion transmembrane transport', 'positive regulation of the force of heart contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of heart contraction', 'regulation of neurogenesis', 'regulation of sensory perception of pain', 'regulation of sodium ion transport', 'response to activity', 'response to estrogen', 'response to ethanol', 'response to heat', 'response to hormone', 'response to hypoxia', 'response to lead ion', 'response to lipopolysaccharide', 'response to nicotine', 'response to nitric oxide', 'response to nutrient levels', 'response to organic cyclic compound', 'response to organonitrogen compound', 'response to peptide hormone', 'response to vitamin E', 'retrograde trans-synaptic signaling by nitric oxide', 'striated muscle contraction', 'synaptic signaling by nitric oxide', 'vasodilation', 'xenobiotic catabolic process']
Nitric oxide synthase, brain
336
Nitric oxide synthase, brain
331
3.7
75
0.36
P29475P29475['arginine catabolic process', 'cell redox homeostasis', 'cellular response to growth factor stimulus', 'multicellular organismal response to stress', 'muscle contraction', 'myoblast fusion', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of calcium ion transport into cytosol', 'negative regulation of hydrolase activity', 'negative regulation of potassium ion transport', 'negative regulation of serotonin uptake', 'neurotransmitter biosynthetic process', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of guanylate cyclase activity', 'positive regulation of histone acetylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of sodium ion transmembrane transport', 'positive regulation of the force of heart contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of calcium ion transmembrane transport via high voltage-gated calcium channel', 'regulation of cardiac muscle contraction', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of sodium ion transport', 'response to heat', 'response to hormone', 'response to hypoxia', 'response to lipopolysaccharide', 'retrograde trans-synaptic signaling by nitric oxide', 'striated muscle contraction', 'vasodilation', 'xenobiotic catabolic process']['arginine catabolic process', 'cell redox homeostasis', 'cellular response to growth factor stimulus', 'multicellular organismal response to stress', 'muscle contraction', 'myoblast fusion', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of calcium ion transport into cytosol', 'negative regulation of hydrolase activity', 'negative regulation of potassium ion transport', 'negative regulation of serotonin uptake', 'neurotransmitter biosynthetic process', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of guanylate cyclase activity', 'positive regulation of histone acetylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of sodium ion transmembrane transport', 'positive regulation of the force of heart contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of calcium ion transmembrane transport via high voltage-gated calcium channel', 'regulation of cardiac muscle contraction', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of sodium ion transport', 'response to heat', 'response to hormone', 'response to hypoxia', 'response to lipopolysaccharide', 'retrograde trans-synaptic signaling by nitric oxide', 'striated muscle contraction', 'vasodilation', 'xenobiotic catabolic process']
Nitric oxide synthase, brain
336
Nitric oxide synthase, brain
336
3.7
85
0.32
P29475P29475['arginine catabolic process', 'cell redox homeostasis', 'cellular response to growth factor stimulus', 'multicellular organismal response to stress', 'muscle contraction', 'myoblast fusion', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of calcium ion transport into cytosol', 'negative regulation of hydrolase activity', 'negative regulation of potassium ion transport', 'negative regulation of serotonin uptake', 'neurotransmitter biosynthetic process', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of guanylate cyclase activity', 'positive regulation of histone acetylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of sodium ion transmembrane transport', 'positive regulation of the force of heart contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of calcium ion transmembrane transport via high voltage-gated calcium channel', 'regulation of cardiac muscle contraction', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of sodium ion transport', 'response to heat', 'response to hormone', 'response to hypoxia', 'response to lipopolysaccharide', 'retrograde trans-synaptic signaling by nitric oxide', 'striated muscle contraction', 'vasodilation', 'xenobiotic catabolic process']['arginine catabolic process', 'cell redox homeostasis', 'cellular response to growth factor stimulus', 'multicellular organismal response to stress', 'muscle contraction', 'myoblast fusion', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of calcium ion transport into cytosol', 'negative regulation of hydrolase activity', 'negative regulation of potassium ion transport', 'negative regulation of serotonin uptake', 'neurotransmitter biosynthetic process', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of guanylate cyclase activity', 'positive regulation of histone acetylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of sodium ion transmembrane transport', 'positive regulation of the force of heart contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of calcium ion transmembrane transport via high voltage-gated calcium channel', 'regulation of cardiac muscle contraction', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of sodium ion transport', 'response to heat', 'response to hormone', 'response to hypoxia', 'response to lipopolysaccharide', 'retrograde trans-synaptic signaling by nitric oxide', 'striated muscle contraction', 'vasodilation', 'xenobiotic catabolic process']
Nitric oxide synthase, endothelial
99
Nitric oxide synthase, endothelial
99
3.7
82
0.33
P29474P29474['angiogenesis', 'aortic valve morphogenesis', 'arginine catabolic process', 'blood vessel diameter maintenance', 'blood vessel remodeling', 'calcium ion transport', 'cell redox homeostasis', 'endocardial cushion morphogenesis', 'endothelial cell migration', 'establishment of localization in cell', 'homeostasis of number of cells within a tissue', 'in utero embryonic development', 'lipopolysaccharide-mediated signaling pathway', 'lung development', 'mitochondrion organization', 'negative regulation of biomineral tissue development', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of cell population proliferation', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrolase activity', 'negative regulation of muscle hyperplasia', 'negative regulation of platelet activation', 'negative regulation of potassium ion transport', 'negative regulation of smooth muscle cell proliferation', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'ovulation from ovarian follicle', 'positive regulation of angiogenesis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of gene expression', 'positive regulation of guanylate cyclase activity', 'positive regulation of Notch signaling pathway', 'potassium ion transport', 'pulmonary valve morphogenesis', 'regulation of blood pressure', 'regulation of nervous system process', 'regulation of sodium ion transport', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of the force of heart contraction by chemical signal', 'removal of superoxide radicals', 'response to fluid shear stress', 'response to heat', 'response to hormone', 'response to lipopolysaccharide', 'smooth muscle hyperplasia', 'vasodilation', 'ventricular septum morphogenesis']['angiogenesis', 'aortic valve morphogenesis', 'arginine catabolic process', 'blood vessel diameter maintenance', 'blood vessel remodeling', 'calcium ion transport', 'cell redox homeostasis', 'endocardial cushion morphogenesis', 'endothelial cell migration', 'establishment of localization in cell', 'homeostasis of number of cells within a tissue', 'in utero embryonic development', 'lipopolysaccharide-mediated signaling pathway', 'lung development', 'mitochondrion organization', 'negative regulation of biomineral tissue development', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of cell population proliferation', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrolase activity', 'negative regulation of muscle hyperplasia', 'negative regulation of platelet activation', 'negative regulation of potassium ion transport', 'negative regulation of smooth muscle cell proliferation', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'ovulation from ovarian follicle', 'positive regulation of angiogenesis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of gene expression', 'positive regulation of guanylate cyclase activity', 'positive regulation of Notch signaling pathway', 'potassium ion transport', 'pulmonary valve morphogenesis', 'regulation of blood pressure', 'regulation of nervous system process', 'regulation of sodium ion transport', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of the force of heart contraction by chemical signal', 'removal of superoxide radicals', 'response to fluid shear stress', 'response to heat', 'response to hormone', 'response to lipopolysaccharide', 'smooth muscle hyperplasia', 'vasodilation', 'ventricular septum morphogenesis']
Acetyl-CoA acetyltransferase, mitochondrial
142
Acetyl-CoA acetyltransferase, mitochondrial
142
3.7
72
0.38
P24752P24752['acetyl-CoA biosynthetic process', 'acetyl-CoA catabolic process', 'adipose tissue development', 'brain development', 'coenzyme A biosynthetic process', 'coenzyme A metabolic process', 'fatty acid beta-oxidation', 'isoleucine catabolic process', 'ketone body catabolic process', 'ketone body metabolic process', 'liver development', 'metanephric proximal convoluted tubule development', 'propionyl-CoA biosynthetic process', 'response to hormone', 'response to organic cyclic compound', 'response to starvation']['acetyl-CoA biosynthetic process', 'acetyl-CoA catabolic process', 'adipose tissue development', 'brain development', 'coenzyme A biosynthetic process', 'coenzyme A metabolic process', 'fatty acid beta-oxidation', 'isoleucine catabolic process', 'ketone body catabolic process', 'ketone body metabolic process', 'liver development', 'metanephric proximal convoluted tubule development', 'propionyl-CoA biosynthetic process', 'response to hormone', 'response to organic cyclic compound', 'response to starvation']
Ubiquitin carboxyl-terminal hydrolase MINDY-2
429
Ubiquitin carboxyl-terminal hydrolase MINDY-2
429
3.7
87
0.31
Q8NBR6Q8NBR6['protein K48-linked deubiquitination']['protein K48-linked deubiquitination']
Nitric oxide synthase, inducible
115
Nitric oxide synthase, inducible
110
3.7
73
0.37
P35228P35228['arginine catabolic process', 'cell redox homeostasis', 'cellular response to interferon-gamma', 'cellular response to lipopolysaccharide', 'cellular response to xenobiotic stimulus', 'circadian rhythm', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'inflammatory response', 'innate immune response in mucosa', 'negative regulation of blood pressure', 'negative regulation of gene expression', 'negative regulation of protein catabolic process', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of guanylate cyclase activity', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of killing of cells of another organism', 'positive regulation of leukocyte mediated cytotoxicity', 'prostaglandin secretion', 'regulation of cell population proliferation', 'regulation of cellular respiration', 'regulation of cytokine production involved in inflammatory response', 'regulation of insulin secretion', 'response to bacterium', 'response to hormone', 'response to hypoxia', 'response to lipopolysaccharide', 'superoxide metabolic process']['arginine catabolic process', 'cell redox homeostasis', 'cellular response to interferon-gamma', 'cellular response to lipopolysaccharide', 'cellular response to xenobiotic stimulus', 'circadian rhythm', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'inflammatory response', 'innate immune response in mucosa', 'negative regulation of blood pressure', 'negative regulation of gene expression', 'negative regulation of protein catabolic process', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of guanylate cyclase activity', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of killing of cells of another organism', 'positive regulation of leukocyte mediated cytotoxicity', 'prostaglandin secretion', 'regulation of cell population proliferation', 'regulation of cellular respiration', 'regulation of cytokine production involved in inflammatory response', 'regulation of insulin secretion', 'response to bacterium', 'response to hormone', 'response to hypoxia', 'response to lipopolysaccharide', 'superoxide metabolic process']
F-box only protein 11
872
F-box only protein 11
890
3.7
65
0.42
Q86XK2Q86XK2['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']
Malonyl-CoA decarboxylase, mitochondrial
206
Malonyl-CoA decarboxylase, mitochondrial
206
3.7
66
0.41
1
✔O95822O95822['acetyl-CoA biosynthetic process', 'acyl-CoA metabolic process', 'fatty acid biosynthetic process', 'fatty acid oxidation', 'malonyl-CoA catabolic process', 'positive regulation of fatty acid oxidation', 'regulation of fatty acid beta-oxidation', 'regulation of glucose metabolic process', 'response to ischemia']['acetyl-CoA biosynthetic process', 'acyl-CoA metabolic process', 'fatty acid biosynthetic process', 'fatty acid oxidation', 'malonyl-CoA catabolic process', 'positive regulation of fatty acid oxidation', 'regulation of fatty acid beta-oxidation', 'regulation of glucose metabolic process', 'response to ischemia']
C-C motif chemokine 1
33
C-C motif chemokine 1
33
3.7
74
0.36
P22362P22362['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of inflammatory response', 'positive regulation of interleukin-17 production', 'positive regulation of monocyte chemotaxis', 'signal transduction', 'viral process']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of inflammatory response', 'positive regulation of interleukin-17 production', 'positive regulation of monocyte chemotaxis', 'signal transduction', 'viral process']
Gasdermin-D
299
Gasdermin-D
299
3.7
92
0.29
Q9D8T2Q9D8T2['cellular response to extracellular stimulus', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'inflammatory response', 'innate immune response', 'pore complex assembly', 'pore formation in membrane of another organism', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-1 production', 'positive regulation of interleukin-18 production', 'protein homooligomerization', 'pyroptosis']['cellular response to extracellular stimulus', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'inflammatory response', 'innate immune response', 'pore complex assembly', 'pore formation in membrane of another organism', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-1 production', 'positive regulation of interleukin-18 production', 'protein homooligomerization', 'pyroptosis']
Copper transport protein ATOX1
12
Copper transport protein ATOX1
12
3.7
48
0.56
O00244O00244['cellular copper ion homeostasis', 'copper ion transport', 'response to oxidative stress']['cellular copper ion homeostasis', 'copper ion transport', 'response to oxidative stress']
Caspase-7
100
Caspase-7
246
3.7
66
0.41
P55210P55210['apoptotic process', 'cellular response to staurosporine', 'execution phase of apoptosis', 'extrinsic apoptotic signaling pathway', 'fibroblast apoptotic process', 'heart development', 'inflammatory response', 'intrinsic apoptotic signaling pathway', 'neuron apoptotic process', 'positive regulation of apoptotic process', 'protein processing', 'proteolysis', 'response to UV']['apoptotic process', 'cellular response to staurosporine', 'execution phase of apoptosis', 'extrinsic apoptotic signaling pathway', 'fibroblast apoptotic process', 'heart development', 'inflammatory response', 'intrinsic apoptotic signaling pathway', 'neuron apoptotic process', 'positive regulation of apoptotic process', 'protein processing', 'proteolysis', 'response to UV']
Fibrinogen beta chain
223
Fibrinogen gamma chain
161
3.7
75
0.36
P02675Q53Y18['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Hepatocyte growth factor
128
Hepatocyte growth factor
128
3.7
83
0.33
P14210P14210['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'mitotic cell cycle', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of autophagy', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'mitotic cell cycle', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of autophagy', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']
Fibrinogen alpha chain
184
Fibrinogen gamma chain
161
3.7
78
0.34
P02671P02679['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Protein diaphanous homolog 1
428
Protein diaphanous homolog 1
428
2.0
76
0.64
O08808O08808['actin cytoskeleton organization', 'actin filament polymerization', 'brain development', 'cellular response to histamine', 'cytoskeleton organization', 'neuron projection development', 'positive regulation of cell migration', 'protein localization to microtubule', 'regulation of cell shape', 'regulation of cytoskeleton organization', 'regulation of microtubule-based process', 'regulation of release of sequestered calcium ion into cytosol', 'sensory perception of sound']['actin cytoskeleton organization', 'actin filament polymerization', 'brain development', 'cellular response to histamine', 'cytoskeleton organization', 'neuron projection development', 'positive regulation of cell migration', 'protein localization to microtubule', 'regulation of cell shape', 'regulation of cytoskeleton organization', 'regulation of microtubule-based process', 'regulation of release of sequestered calcium ion into cytosol', 'sensory perception of sound']
Fibrinogen beta chain
227
Fibrinogen gamma chain
165
2.0
64
0.76
P02675Q53Y18['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Insulin
97
Insulin
43
2.0
46
1.06
A6XGL2A6XGL2['glucose metabolic process']['glucose metabolic process']
Fragile X messenger ribonucleoprotein 1
99
Fragile X messenger ribonucleoprotein 1
99
2.0
71
0.69
Q06787Q06787['cellular response to virus', 'DNA repair', 'gene silencing by RNA', 'glutamate receptor signaling pathway', 'modulation by host of viral RNA genome replication', 'mRNA processing', 'mRNA transport', 'negative regulation of cytoplasmic translation', 'negative regulation of long-term synaptic depression', 'negative regulation of mRNA catabolic process', 'negative regulation of synaptic vesicle exocytosis', 'negative regulation of translation', 'negative regulation of translational initiation', 'negative regulation of voltage-gated calcium channel activity', 'nervous system development', 'positive regulation of dendritic spine development', 'positive regulation of filopodium assembly', 'positive regulation of intracellular transport of viral material', 'positive regulation of miRNA-mediated gene silencing', 'positive regulation of mRNA binding', 'positive regulation of proteasomal protein catabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of receptor internalization', 'positive regulation of response to DNA damage stimulus', 'positive regulation of translation', 'regulation of alternative mRNA splicing, via spliceosome', 'regulation of dendritic spine development', 'regulation of filopodium assembly', 'regulation of miRNA-mediated gene silencing', 'regulation of mRNA stability', 'regulation of neuronal action potential', 'regulation of neurotransmitter secretion', 'RNA splicing']['cellular response to virus', 'DNA repair', 'gene silencing by RNA', 'glutamate receptor signaling pathway', 'modulation by host of viral RNA genome replication', 'mRNA processing', 'mRNA transport', 'negative regulation of cytoplasmic translation', 'negative regulation of long-term synaptic depression', 'negative regulation of mRNA catabolic process', 'negative regulation of synaptic vesicle exocytosis', 'negative regulation of translation', 'negative regulation of translational initiation', 'negative regulation of voltage-gated calcium channel activity', 'nervous system development', 'positive regulation of dendritic spine development', 'positive regulation of filopodium assembly', 'positive regulation of intracellular transport of viral material', 'positive regulation of miRNA-mediated gene silencing', 'positive regulation of mRNA binding', 'positive regulation of proteasomal protein catabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of receptor internalization', 'positive regulation of response to DNA damage stimulus', 'positive regulation of translation', 'regulation of alternative mRNA splicing, via spliceosome', 'regulation of dendritic spine development', 'regulation of filopodium assembly', 'regulation of miRNA-mediated gene silencing', 'regulation of mRNA stability', 'regulation of neuronal action potential', 'regulation of neurotransmitter secretion', 'RNA splicing']
Trypsin
117
Trypsin
218
2.0
59
0.83
P00761P00761['digestion', 'proteolysis']['digestion', 'proteolysis']
Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7
47
Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7
47
2.0
81
0.6
P0C870P0C870['protein hydroxylation', 'proteolysis']['protein hydroxylation', 'proteolysis']
Growth/differentiation factor 5
465
Growth/differentiation factor 5
465
2.0
85
0.58
P43026P43026['BMP signaling pathway', 'cell-cell signaling', 'chondroblast differentiation', 'chondrocyte differentiation', 'embryonic limb morphogenesis', 'forelimb morphogenesis', 'hindlimb morphogenesis', 'mesenchymal cell apoptotic process', 'negative regulation of chondrocyte differentiation', 'negative regulation of epithelial cell proliferation', 'negative regulation of mesenchymal cell apoptotic process', 'negative regulation of neuron apoptotic process', 'ossification involved in bone remodeling', 'positive regulation of BMP signaling pathway', 'positive regulation of chondrocyte differentiation', 'positive regulation of neuron differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'regulation of multicellular organism growth', 'regulation of SMAD protein signal transduction', 'response to mechanical stimulus', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['BMP signaling pathway', 'cell-cell signaling', 'chondroblast differentiation', 'chondrocyte differentiation', 'embryonic limb morphogenesis', 'forelimb morphogenesis', 'hindlimb morphogenesis', 'mesenchymal cell apoptotic process', 'negative regulation of chondrocyte differentiation', 'negative regulation of epithelial cell proliferation', 'negative regulation of mesenchymal cell apoptotic process', 'negative regulation of neuron apoptotic process', 'ossification involved in bone remodeling', 'positive regulation of BMP signaling pathway', 'positive regulation of chondrocyte differentiation', 'positive regulation of neuron differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'regulation of multicellular organism growth', 'regulation of SMAD protein signal transduction', 'response to mechanical stimulus', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
Fibrinogen alpha chain
68
Fibrinogen beta chain
106
2.0
75
0.65
P02671P02675['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']
Signal recognition particle receptor subunit alpha
621
Signal recognition particle receptor subunit alpha
621
2.0
66
0.74
P08240P08240['cotranslational protein targeting to membrane', 'protein targeting', 'protein targeting to ER', 'SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition']['cotranslational protein targeting to membrane', 'protein targeting', 'protein targeting to ER', 'SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition']
Copper transport protein ATOX1
12
Copper transport protein ATOX1
15
3.7
65
0.42
O00244O00244['cellular copper ion homeostasis', 'copper ion transport', 'response to oxidative stress']['cellular copper ion homeostasis', 'copper ion transport', 'response to oxidative stress']
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
112
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
193
3.6
74
0.37
Q9TTF5Q9TTF5['metabolic process']['metabolic process']
Anaphase-promoting complex subunit 11
73
Anaphase-promoting complex subunit 11
51
3.7
52
0.53
Q9NYG5Q9NYG5['anaphase-promoting complex-dependent catabolic process', 'cell division', 'mitotic cell cycle', 'positive regulation of mitotic metaphase/anaphase transition', 'protein K11-linked ubiquitination', 'protein ubiquitination', 'regulation of meiotic cell cycle', 'regulation of mitotic cell cycle', 'ubiquitin-dependent protein catabolic process']['anaphase-promoting complex-dependent catabolic process', 'cell division', 'mitotic cell cycle', 'positive regulation of mitotic metaphase/anaphase transition', 'protein K11-linked ubiquitination', 'protein ubiquitination', 'regulation of meiotic cell cycle', 'regulation of mitotic cell cycle', 'ubiquitin-dependent protein catabolic process']
Rab-3A-interacting protein
195
Rab-3A-interacting protein
195
3.7
48
0.57
Q96QF0Q96QF0['ciliary basal body-plasma membrane docking', 'cilium assembly', 'exocytosis', 'Golgi to plasma membrane transport', 'negative regulation of filopodium assembly', 'protein localization to organelle', 'protein targeting to membrane']['ciliary basal body-plasma membrane docking', 'cilium assembly', 'exocytosis', 'Golgi to plasma membrane transport', 'negative regulation of filopodium assembly', 'protein localization to organelle', 'protein targeting to membrane']
Cytidine deaminase
59
Cytidine deaminase
99
3.7
92
0.3
P56389P56389['cellular response to external biotic stimulus', 'CMP catabolic process', 'cytidine deamination', 'dCMP catabolic process', 'negative regulation of cell growth', 'negative regulation of nucleotide metabolic process', 'response to cycloheximide', 'UMP salvage']['cellular response to external biotic stimulus', 'CMP catabolic process', 'cytidine deamination', 'dCMP catabolic process', 'negative regulation of cell growth', 'negative regulation of nucleotide metabolic process', 'response to cycloheximide', 'UMP salvage']
Potassium voltage-gated channel subfamily D member 3
131
Potassium voltage-gated channel subfamily D member 3
110
3.7
61
0.44
Q62897Q62897['cellular response to BMP stimulus', 'membrane repolarization', 'membrane repolarization during ventricular cardiac muscle cell action potential', 'potassium ion export across plasma membrane', 'potassium ion import across plasma membrane', 'potassium ion transmembrane transport', 'potassium ion transport', 'protein homooligomerization', 'regulation of heart rate by cardiac conduction', 'regulation of ion transmembrane transport', 'ventricular cardiac muscle cell membrane repolarization']['cellular response to BMP stimulus', 'membrane repolarization', 'membrane repolarization during ventricular cardiac muscle cell action potential', 'potassium ion export across plasma membrane', 'potassium ion import across plasma membrane', 'potassium ion transmembrane transport', 'potassium ion transport', 'protein homooligomerization', 'regulation of heart rate by cardiac conduction', 'regulation of ion transmembrane transport', 'ventricular cardiac muscle cell membrane repolarization']
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
107
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
106
3.7
100
0.27
Q9H3H5Q9H3H5['dolichol metabolic process', 'dolichol-linked oligosaccharide biosynthetic process', 'protein N-linked glycosylation', 'UDP-N-acetylglucosamine metabolic process']['dolichol metabolic process', 'dolichol-linked oligosaccharide biosynthetic process', 'protein N-linked glycosylation', 'UDP-N-acetylglucosamine metabolic process']
BAH and coiled-coil domain-containing protein 1
2582
BAH and coiled-coil domain-containing protein 1
2582
3.7
60
0.46
Q3UHR0Q3UHR0[][]
Germinal-center associated nuclear protein
1189
Transcription and mRNA export factor ENY2
50
3.7
79
0.35
O60318Q9NPA8['mRNA export from nucleus', 'nucleosome organization', 'poly(A)+ mRNA export from nucleus', 'protein transport', 'somatic hypermutation of immunoglobulin genes']['chromatin organization', 'histone deubiquitination', 'histone H3 acetylation', 'monoubiquitinated histone deubiquitination', 'monoubiquitinated histone H2A deubiquitination', 'poly(A)+ mRNA export from nucleus', 'positive regulation of transcription, DNA-templated', 'protein transport', 'regulation of DNA repair', 'regulation of RNA splicing', 'regulation of transcription by RNA polymerase II', 'transcription elongation from RNA polymerase II promoter']
Thymidylate synthase
180
Thymidylate synthase
180
3.7
88
0.31
P04818P04818['aging', 'cartilage development', 'circadian rhythm', 'developmental growth', 'DNA biosynthetic process', 'dTMP biosynthetic process', 'dTTP biosynthetic process', 'intestinal epithelial cell maturation', 'liver regeneration', 'methylation', 'negative regulation of translation', 'response to cytokine', 'response to ethanol', 'response to folic acid', 'response to glucocorticoid', 'response to organophosphorus', 'response to progesterone', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'tetrahydrofolate interconversion', 'uracil metabolic process']['aging', 'cartilage development', 'circadian rhythm', 'developmental growth', 'DNA biosynthetic process', 'dTMP biosynthetic process', 'dTTP biosynthetic process', 'intestinal epithelial cell maturation', 'liver regeneration', 'methylation', 'negative regulation of translation', 'response to cytokine', 'response to ethanol', 'response to folic acid', 'response to glucocorticoid', 'response to organophosphorus', 'response to progesterone', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'tetrahydrofolate interconversion', 'uracil metabolic process']
Nitric-oxide synthase (NADPH)
99
Nitric-oxide synthase (NADPH)
99
3.7
84
0.32
A0S0A6A0S0A6['nitric oxide biosynthetic process']['nitric oxide biosynthetic process']
Transducin-like enhancer protein 1
47
Transducin-like enhancer protein 1
47
3.7
52
0.52
Q04724Q04724['animal organ morphogenesis', 'negative regulation of anoikis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of transcription, DNA-templated', 'negative regulation of Wnt signaling pathway', 'positive regulation of gene expression', 'signal transduction', 'Wnt signaling pathway']['animal organ morphogenesis', 'negative regulation of anoikis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of transcription, DNA-templated', 'negative regulation of Wnt signaling pathway', 'positive regulation of gene expression', 'signal transduction', 'Wnt signaling pathway']
General transcription factor IIH subunit 3
142
General transcription factor IIH subunit 2
371
3.7
84
0.32
Q13889Q13888['DNA repair', 'nucleotide-excision repair', 'phosphorylation of RNA polymerase II C-terminal domain', 'transcription by RNA polymerase II']['G protein-coupled receptor internalization', 'nucleotide-excision repair', 'positive regulation of DNA helicase activity', 'regulation of transcription by RNA polymerase II', 'response to UV', 'transcription by RNA polymerase II', 'transcription initiation from RNA polymerase II promoter']
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
201
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
119
3.7
83
0.32
P28907P28907['apoptotic signaling pathway', 'artery smooth muscle contraction', 'B cell proliferation', 'B cell receptor signaling pathway', 'female pregnancy', 'long-term synaptic depression', 'NAD metabolic process', 'negative regulation of apoptotic process', 'negative regulation of bone resorption', 'negative regulation of neuron projection development', 'negative regulation of transcription, DNA-templated', 'positive regulation of B cell proliferation', 'positive regulation of cell growth', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of insulin secretion', 'positive regulation of transcription, DNA-templated', 'positive regulation of vasoconstriction', 'response to estradiol', 'response to hydroperoxide', 'response to hypoxia', 'response to interleukin-1', 'response to progesterone', 'response to retinoic acid', 'response to xenobiotic stimulus', 'signal transduction']['apoptotic signaling pathway', 'artery smooth muscle contraction', 'B cell proliferation', 'B cell receptor signaling pathway', 'female pregnancy', 'long-term synaptic depression', 'NAD metabolic process', 'negative regulation of apoptotic process', 'negative regulation of bone resorption', 'negative regulation of neuron projection development', 'negative regulation of transcription, DNA-templated', 'positive regulation of B cell proliferation', 'positive regulation of cell growth', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of insulin secretion', 'positive regulation of transcription, DNA-templated', 'positive regulation of vasoconstriction', 'response to estradiol', 'response to hydroperoxide', 'response to hypoxia', 'response to interleukin-1', 'response to progesterone', 'response to retinoic acid', 'response to xenobiotic stimulus', 'signal transduction']
ADP-sugar pyrophosphatase
91
ADP-sugar pyrophosphatase
131
3.7
85
0.32
Q9UKK9Q9UKK9['ATP generation from poly-ADP-D-ribose', 'chromatin remodeling', 'D-ribose catabolic process', 'nucleobase-containing small molecule metabolic process', 'nucleoside phosphate metabolic process', 'nucleotide metabolic process', 'ribonucleoside diphosphate catabolic process', 'ribose phosphate metabolic process']['ATP generation from poly-ADP-D-ribose', 'chromatin remodeling', 'D-ribose catabolic process', 'nucleobase-containing small molecule metabolic process', 'nucleoside phosphate metabolic process', 'nucleotide metabolic process', 'ribonucleoside diphosphate catabolic process', 'ribose phosphate metabolic process']
Nitric oxide synthase, brain
331
Nitric oxide synthase, brain
331
3.7
70
0.39
P29475P29475['arginine catabolic process', 'cell redox homeostasis', 'cellular response to growth factor stimulus', 'multicellular organismal response to stress', 'muscle contraction', 'myoblast fusion', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of calcium ion transport into cytosol', 'negative regulation of hydrolase activity', 'negative regulation of potassium ion transport', 'negative regulation of serotonin uptake', 'neurotransmitter biosynthetic process', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of guanylate cyclase activity', 'positive regulation of histone acetylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of sodium ion transmembrane transport', 'positive regulation of the force of heart contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of calcium ion transmembrane transport via high voltage-gated calcium channel', 'regulation of cardiac muscle contraction', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of sodium ion transport', 'response to heat', 'response to hormone', 'response to hypoxia', 'response to lipopolysaccharide', 'retrograde trans-synaptic signaling by nitric oxide', 'striated muscle contraction', 'vasodilation', 'xenobiotic catabolic process']['arginine catabolic process', 'cell redox homeostasis', 'cellular response to growth factor stimulus', 'multicellular organismal response to stress', 'muscle contraction', 'myoblast fusion', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of calcium ion transport into cytosol', 'negative regulation of hydrolase activity', 'negative regulation of potassium ion transport', 'negative regulation of serotonin uptake', 'neurotransmitter biosynthetic process', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of guanylate cyclase activity', 'positive regulation of histone acetylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of sodium ion transmembrane transport', 'positive regulation of the force of heart contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of calcium ion transmembrane transport via high voltage-gated calcium channel', 'regulation of cardiac muscle contraction', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of sodium ion transport', 'response to heat', 'response to hormone', 'response to hypoxia', 'response to lipopolysaccharide', 'retrograde trans-synaptic signaling by nitric oxide', 'striated muscle contraction', 'vasodilation', 'xenobiotic catabolic process']
Transducin-like enhancer protein 1
89
Transducin-like enhancer protein 1
89
3.7
75
0.36
Q04724Q04724['animal organ morphogenesis', 'negative regulation of anoikis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of transcription, DNA-templated', 'negative regulation of Wnt signaling pathway', 'positive regulation of gene expression', 'signal transduction', 'Wnt signaling pathway']['animal organ morphogenesis', 'negative regulation of anoikis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of transcription, DNA-templated', 'negative regulation of Wnt signaling pathway', 'positive regulation of gene expression', 'signal transduction', 'Wnt signaling pathway']
Trypsin-2
30
Trypsin-2
160
2.0
64
0.76
P07478P07478['antimicrobial humoral response', 'collagen catabolic process', 'digestion', 'extracellular matrix disassembly', 'positive regulation of cell adhesion', 'positive regulation of cell growth', 'proteolysis']['antimicrobial humoral response', 'collagen catabolic process', 'digestion', 'extracellular matrix disassembly', 'positive regulation of cell adhesion', 'positive regulation of cell growth', 'proteolysis']
Acyloxyacyl hydrolase
122
Acyloxyacyl hydrolase
453
2.0
65
0.75
O18823O18823['fatty acid metabolic process', 'lipopolysaccharide catabolic process']['fatty acid metabolic process', 'lipopolysaccharide catabolic process']
Interleukin-17F
47
Interleukin-17F
137
2.0
35
1.4
Q96PD4Q96PD4['adaptive immune response', 'cartilage development', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'inflammatory response', 'innate immune response', 'interleukin-17-mediated signaling pathway', 'negative regulation of angiogenesis', 'positive regulation of antimicrobial peptide production', 'positive regulation of chemokine (C-X-C motif) ligand 1 production', 'positive regulation of cytokine production', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of interleukin-6 production', 'positive regulation of lymphotoxin A production', 'positive regulation of transcription by RNA polymerase II', 'regulation of granulocyte macrophage colony-stimulating factor production', 'regulation of interleukin-2 production', 'regulation of interleukin-6 production', 'regulation of interleukin-8 production', 'regulation of transforming growth factor beta receptor signaling pathway']['adaptive immune response', 'cartilage development', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'inflammatory response', 'innate immune response', 'interleukin-17-mediated signaling pathway', 'negative regulation of angiogenesis', 'positive regulation of antimicrobial peptide production', 'positive regulation of chemokine (C-X-C motif) ligand 1 production', 'positive regulation of cytokine production', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of interleukin-6 production', 'positive regulation of lymphotoxin A production', 'positive regulation of transcription by RNA polymerase II', 'regulation of granulocyte macrophage colony-stimulating factor production', 'regulation of interleukin-2 production', 'regulation of interleukin-6 production', 'regulation of interleukin-8 production', 'regulation of transforming growth factor beta receptor signaling pathway']
Golgi-associated PDZ and coiled-coil motif-containing protein
327
Golgi-associated PDZ and coiled-coil motif-containing protein
327
2.0
70
0.7
Q9HD26Q9HD26['apical protein localization', 'cytoplasmic sequestering of CFTR protein', 'endoplasmic reticulum to Golgi vesicle-mediated transport', 'Golgi to plasma membrane transport', 'negative regulation of anion channel activity', 'negative regulation of protein localization to cell surface', 'protein transport']['apical protein localization', 'cytoplasmic sequestering of CFTR protein', 'endoplasmic reticulum to Golgi vesicle-mediated transport', 'Golgi to plasma membrane transport', 'negative regulation of anion channel activity', 'negative regulation of protein localization to cell surface', 'protein transport']
Complement C4-A
1394
Complement C4-A
1566
2.0
60
0.82
P0C0L4P0C0L4['complement activation', 'complement activation, classical pathway', 'inflammatory response', 'innate immune response', 'positive regulation of apoptotic cell clearance', 'positive regulation of immune response', 'positive regulation of opsonization']['complement activation', 'complement activation, classical pathway', 'inflammatory response', 'innate immune response', 'positive regulation of apoptotic cell clearance', 'positive regulation of immune response', 'positive regulation of opsonization']
Fibrinogen gamma-B chain
33
Fibrinogen gamma-B chain
32
2.0
63
0.78
P12799P12799['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'platelet aggregation', 'protein polymerization']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'platelet aggregation', 'protein polymerization']
Apoptotic chromatin condensation inducer in the nucleus
1083
Apoptotic chromatin condensation inducer in the nucleus
1083
2.0
78
0.63
Q9UKV3Q9UKV3['apoptotic chromosome condensation', 'erythrocyte differentiation', 'mRNA processing', 'negative regulation of mRNA splicing, via spliceosome', 'positive regulation of apoptotic process', 'positive regulation of monocyte differentiation', 'RNA splicing']['apoptotic chromosome condensation', 'erythrocyte differentiation', 'mRNA processing', 'negative regulation of mRNA splicing, via spliceosome', 'positive regulation of apoptotic process', 'positive regulation of monocyte differentiation', 'RNA splicing']
Ceramide-1-phosphate transfer protein
163
Ceramide-1-phosphate transfer protein
163
2.0
58
0.85
Q5TA50Q5TA50['ceramide 1-phosphate transport', 'ceramide transport', 'glycosphingolipid metabolic process', 'intermembrane lipid transfer', 'negative regulation of autophagy', 'negative regulation of interleukin-1 beta production', 'negative regulation of NLRP3 inflammasome complex assembly']['ceramide 1-phosphate transport', 'ceramide transport', 'glycosphingolipid metabolic process', 'intermembrane lipid transfer', 'negative regulation of autophagy', 'negative regulation of interleukin-1 beta production', 'negative regulation of NLRP3 inflammasome complex assembly']
Fibrinogen alpha chain
180
Fibrinogen gamma chain
161
2.0
86
0.57
P02671Q53Y18['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Tyrosine-protein phosphatase non-receptor type 4
590
Tyrosine-protein phosphatase non-receptor type 4
590
2.0
73
0.67
P29074P29074['peptidyl-tyrosine phosphorylation', 'protein dephosphorylation']['peptidyl-tyrosine phosphorylation', 'protein dephosphorylation']
Protein timeless homolog
1038
Poly [ADP-ribose] polymerase 1
845
2.0
64
0.76
Q9UNS1P09874['branching morphogenesis of an epithelial tube', 'cell cycle phase transition', 'cell division', 'cellular response to bleomycin', 'cellular response to cisplatin', 'cellular response to DNA damage stimulus', 'cellular response to hydroxyurea', 'circadian rhythm', 'detection of abiotic stimulus', 'DNA repair', 'DNA replication checkpoint signaling', 'lung development', 'morphogenesis of an epithelium', 'negative regulation of transcription, DNA-templated', 'positive regulation of double-strand break repair', 'positive regulation of double-strand break repair via homologous recombination', 'regulation of circadian rhythm', 'replication fork arrest', 'replication fork protection']['apoptotic process', 'ATP generation from poly-ADP-D-ribose', 'cellular response to amyloid-beta', 'cellular response to DNA damage stimulus', 'cellular response to insulin stimulus', 'cellular response to oxidative stress', 'cellular response to UV', 'cellular response to zinc ion', 'DNA ADP-ribosylation', 'DNA repair', 'double-strand break repair', 'macrophage differentiation', 'mitochondrial DNA metabolic process', 'mitochondrial DNA repair', 'mitochondrion organization', 'negative regulation of ATP biosynthetic process', 'negative regulation of telomere maintenance via telomere lengthening', 'negative regulation of transcription by RNA polymerase II', 'peptidyl-glutamic acid poly-ADP-ribosylation', 'peptidyl-serine ADP-ribosylation', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of double-strand break repair via homologous recombination', 'positive regulation of intracellular estrogen receptor signaling pathway', 'positive regulation of mitochondrial depolarization', 'positive regulation of myofibroblast differentiation', 'positive regulation of neuron death', 'positive regulation of protein localization to nucleus', 'positive regulation of single strand break repair', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'protein ADP-ribosylation', 'protein auto-ADP-ribosylation', 'protein autoprocessing', 'protein modification process', 'protein poly-ADP-ribosylation', 'regulation of catalytic activity', 'regulation of DNA methylation', 'regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'regulation of protein localization', 'regulation of SMAD protein complex assembly', 'response to aldosterone', 'response to gamma radiation', 'signal transduction involved in regulation of gene expression', 'telomere maintenance', 'transcription by RNA polymerase II', 'transforming growth factor beta receptor signaling pathway']
Sorting nexin-24
52
Sorting nexin-24
52
2.0
70
0.7
Q9Y343Q9Y343['protein transport']['protein transport']
Endonuclease G, mitochondrial
110
Endonuclease G, mitochondrial
110
2.0
74
0.66
O08600O08600['aging', 'apoptotic DNA fragmentation', 'cellular response to calcium ion', 'cellular response to glucose stimulus', 'cellular response to hypoxia', 'DNA catabolic process', 'in utero embryonic development', 'mitochondrial DNA catabolic process', 'negative regulation of TOR signaling', 'neuron death in response to oxidative stress', 'positive regulation of apoptotic DNA fragmentation', 'positive regulation of apoptotic process', 'positive regulation of autophagy', 'positive regulation of hydrogen peroxide-mediated programmed cell death', 'positive regulation of mitochondrial DNA replication', 'positive regulation of response to DNA damage stimulus', 'response to antibiotic', 'response to estradiol', 'response to mechanical stimulus', 'response to tumor necrosis factor']['aging', 'apoptotic DNA fragmentation', 'cellular response to calcium ion', 'cellular response to glucose stimulus', 'cellular response to hypoxia', 'DNA catabolic process', 'in utero embryonic development', 'mitochondrial DNA catabolic process', 'negative regulation of TOR signaling', 'neuron death in response to oxidative stress', 'positive regulation of apoptotic DNA fragmentation', 'positive regulation of apoptotic process', 'positive regulation of autophagy', 'positive regulation of hydrogen peroxide-mediated programmed cell death', 'positive regulation of mitochondrial DNA replication', 'positive regulation of response to DNA damage stimulus', 'response to antibiotic', 'response to estradiol', 'response to mechanical stimulus', 'response to tumor necrosis factor']
Growth/differentiation factor 15
273
Growth/differentiation factor 15
273
2.0
89
0.55
Q99988Q99988['BMP signaling pathway', 'cell-cell signaling', 'glial cell-derived neurotrophic factor receptor signaling pathway', 'negative regulation of growth hormone receptor signaling pathway', 'negative regulation of multicellular organism growth', 'positive regulation of MAPK cascade', 'positive regulation of myoblast fusion', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein kinase B signaling', 'reduction of food intake in response to dietary excess', 'signal transduction', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['BMP signaling pathway', 'cell-cell signaling', 'glial cell-derived neurotrophic factor receptor signaling pathway', 'negative regulation of growth hormone receptor signaling pathway', 'negative regulation of multicellular organism growth', 'positive regulation of MAPK cascade', 'positive regulation of myoblast fusion', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein kinase B signaling', 'reduction of food intake in response to dietary excess', 'signal transduction', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
Noelin
221
Noelin
221
2.0
51
0.96
O88998O88998['atrioventricular valve formation', 'cardiac epithelial to mesenchymal transition', 'negative regulation of gene expression', 'nervous system development', 'neuronal signal transduction', 'positive regulation of apoptotic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of gene expression', 'regulation of axon extension', 'signal transduction']['atrioventricular valve formation', 'cardiac epithelial to mesenchymal transition', 'negative regulation of gene expression', 'nervous system development', 'neuronal signal transduction', 'positive regulation of apoptotic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of gene expression', 'regulation of axon extension', 'signal transduction']
Amyloid beta precursor protein binding family B member 1
661
Amyloid beta precursor protein binding family B member 1
661
2.0
90
0.54
O00213O00213['apoptotic process', 'axonogenesis', 'cellular response to DNA damage stimulus', 'chromatin organization', 'histone H4 acetylation', 'negative regulation of cell cycle G1/S phase transition', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of apoptotic process', 'positive regulation of protein secretion', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of transcription, DNA-templated', 'signal transduction', 'smooth muscle contraction']['apoptotic process', 'axonogenesis', 'cellular response to DNA damage stimulus', 'chromatin organization', 'histone H4 acetylation', 'negative regulation of cell cycle G1/S phase transition', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of apoptotic process', 'positive regulation of protein secretion', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of transcription, DNA-templated', 'signal transduction', 'smooth muscle contraction']
PDZ and LIM domain protein 4
44
PDZ and LIM domain protein 4
44
2.0
89
0.55
P50479P50479['actin cytoskeleton organization', 'actin cytoskeleton reorganization', 'excitatory chemical synaptic transmission', 'heart development', 'muscle structure development']['actin cytoskeleton organization', 'actin cytoskeleton reorganization', 'excitatory chemical synaptic transmission', 'heart development', 'muscle structure development']
Recombining binding protein suppressor of hairless
100
Mastermind-like protein 1
63
2.0
76
0.64
Q06330Q92585['angiogenesis', 'aortic valve development', 'arterial endothelial cell fate commitment', 'atrioventricular canal development', 'auditory receptor cell fate commitment', 'B cell differentiation', 'blood vessel endothelial cell fate specification', 'blood vessel lumenization', 'blood vessel remodeling', 'cardiac left ventricle morphogenesis', 'cardiac muscle cell myoblast differentiation', 'club cell differentiation', 'defense response to bacterium', 'dorsal aorta morphogenesis', 'endocardium morphogenesis', 'epidermal cell fate specification', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'epithelial to mesenchymal transition involved in endocardial cushion formation', 'hair follicle maturation', 'humoral immune response', 'inflammatory response to antigenic stimulus', 'keratinocyte differentiation', 'labyrinthine layer blood vessel development', 'myeloid dendritic cell differentiation', 'negative regulation of cell differentiation', 'negative regulation of cold-induced thermogenesis', 'negative regulation of ossification', 'negative regulation of stem cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'Notch signaling involved in heart development', 'Notch signaling pathway', 'outflow tract morphogenesis', 'pituitary gland development', 'positive regulation of BMP signaling pathway', 'positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cell proliferation involved in heart morphogenesis', 'positive regulation of ephrin receptor signaling pathway', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERBB signaling pathway', 'positive regulation of gene expression', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription of Notch receptor target', 'pulmonary valve development', 'regulation of reproductive process', 'regulation of timing of cell differentiation', 'regulation of transcription by RNA polymerase II', 'sebaceous gland development', 'secondary heart field specification', 'somatic stem cell population maintenance', 'somitogenesis', 'stem cell proliferation', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis']['atrioventricular node cell development', 'atrioventricular node development', 'myoblast differentiation', 'Notch signaling pathway', 'positive regulation of myotube differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription of Notch receptor target', 'protein phosphorylation']
Coagulation factor IX
291
Coagulation factor IX
133
2.0
84
0.58
P16293P16293['blood coagulation', 'proteolysis', 'zymogen activation']['blood coagulation', 'proteolysis', 'zymogen activation']
Fibrinogen alpha chain
55
Fibrinogen beta chain
95
2.0
52
0.94
P02671P02675['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']
Thioredoxin
73
Thioredoxin
35
2.0
69
0.71
P10599P10599['activation of protein kinase B activity', 'cell redox homeostasis', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of protein export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA binding', 'positive regulation of peptidyl-cysteine S-nitrosylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'response to nitric oxide', 'response to radiation']['activation of protein kinase B activity', 'cell redox homeostasis', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of protein export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA binding', 'positive regulation of peptidyl-cysteine S-nitrosylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'response to nitric oxide', 'response to radiation']
Interleukin-12 subunit beta
197
Interleukin-12 subunit beta
197
2.0
39
1.26
P43432P43432['cell migration', 'cell population proliferation', 'cell surface receptor signaling pathway', 'cellular response to interferon-gamma', 'cellular response to lipopolysaccharide', 'cytokine-mediated signaling pathway', 'defense response to Gram-negative bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'natural killer cell activation', 'natural killer cell activation involved in immune response', 'negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'negative regulation of inflammatory response to antigenic stimulus', 'negative regulation of interleukin-10 production', 'negative regulation of interleukin-17 production', 'negative regulation of protein secretion', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of vascular endothelial growth factor signaling pathway', 'positive regulation of activated T cell proliferation', 'positive regulation of activation of Janus kinase activity', 'positive regulation of cell adhesion', 'positive regulation of defense response to virus by host', 'positive regulation of granulocyte macrophage colony-stimulating factor production', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-10 production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-17 production', 'positive regulation of lymphocyte proliferation', 'positive regulation of mononuclear cell proliferation', 'positive regulation of natural killer cell activation', 'positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target', 'positive regulation of natural killer cell proliferation', 'positive regulation of NK T cell activation', 'positive regulation of NK T cell proliferation', 'positive regulation of osteoclast differentiation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell apoptotic process', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of T cell proliferation', 'positive regulation of T-helper 1 type immune response', 'positive regulation of T-helper 17 type immune response', 'positive regulation of tumor necrosis factor production', 'positive regulation of tyrosine phosphorylation of STAT protein', 'regulation of tyrosine phosphorylation of STAT protein', 'response to organic substance', 'response to UV-B', 'sensory perception of pain', 'T cell proliferation', 'T-helper cell differentiation']['cell migration', 'cell population proliferation', 'cell surface receptor signaling pathway', 'cellular response to interferon-gamma', 'cellular response to lipopolysaccharide', 'cytokine-mediated signaling pathway', 'defense response to Gram-negative bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'natural killer cell activation', 'natural killer cell activation involved in immune response', 'negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'negative regulation of inflammatory response to antigenic stimulus', 'negative regulation of interleukin-10 production', 'negative regulation of interleukin-17 production', 'negative regulation of protein secretion', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of vascular endothelial growth factor signaling pathway', 'positive regulation of activated T cell proliferation', 'positive regulation of activation of Janus kinase activity', 'positive regulation of cell adhesion', 'positive regulation of defense response to virus by host', 'positive regulation of granulocyte macrophage colony-stimulating factor production', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-10 production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-17 production', 'positive regulation of lymphocyte proliferation', 'positive regulation of mononuclear cell proliferation', 'positive regulation of natural killer cell activation', 'positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target', 'positive regulation of natural killer cell proliferation', 'positive regulation of NK T cell activation', 'positive regulation of NK T cell proliferation', 'positive regulation of osteoclast differentiation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell apoptotic process', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of T cell proliferation', 'positive regulation of T-helper 1 type immune response', 'positive regulation of T-helper 17 type immune response', 'positive regulation of tumor necrosis factor production', 'positive regulation of tyrosine phosphorylation of STAT protein', 'regulation of tyrosine phosphorylation of STAT protein', 'response to organic substance', 'response to UV-B', 'sensory perception of pain', 'T cell proliferation', 'T-helper cell differentiation']
LIM domain kinase 2
365
LIM domain kinase 2
549
2.0
55
0.89
P53671P53671['actin cytoskeleton organization', 'astral microtubule organization', 'cornea development in camera-type eye', 'establishment of vesicle localization', 'head development', 'negative regulation of cilium assembly', 'phosphorylation', 'positive regulation of protein localization to nucleus', 'positive regulation of protein phosphorylation', 'protein phosphorylation', 'spermatogenesis']['actin cytoskeleton organization', 'astral microtubule organization', 'cornea development in camera-type eye', 'establishment of vesicle localization', 'head development', 'negative regulation of cilium assembly', 'phosphorylation', 'positive regulation of protein localization to nucleus', 'positive regulation of protein phosphorylation', 'protein phosphorylation', 'spermatogenesis']
Tumor necrosis factor ligand superfamily member 9
246
Tumor necrosis factor ligand superfamily member 9
246
2.0
51
0.96
P41274P41274['immune response', 'myeloid dendritic cell differentiation', 'positive regulation of activated T cell proliferation', 'positive regulation of cytotoxic T cell differentiation', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-6 production', 'regulation of immature T cell proliferation in thymus']['immune response', 'myeloid dendritic cell differentiation', 'positive regulation of activated T cell proliferation', 'positive regulation of cytotoxic T cell differentiation', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-6 production', 'regulation of immature T cell proliferation in thymus']
Cathepsin B
105
Cathepsin B
150
2.0
72
0.68
P07858P07858['cellular response to thyroid hormone stimulus', 'collagen catabolic process', 'decidualization', 'epithelial cell differentiation', 'negative regulation of peptidase activity', 'proteolysis', 'proteolysis involved in protein catabolic process', 'regulation of apoptotic process', 'thyroid hormone generation', 'viral entry into host cell']['cellular response to thyroid hormone stimulus', 'collagen catabolic process', 'decidualization', 'epithelial cell differentiation', 'negative regulation of peptidase activity', 'proteolysis', 'proteolysis involved in protein catabolic process', 'regulation of apoptotic process', 'thyroid hormone generation', 'viral entry into host cell']
Protein PML
66
Protein PML
66
2.0
64
0.77
P29590P29590['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'apoptotic process', 'branching involved in mammary gland duct morphogenesis', 'cell fate commitment', 'cellular response to interleukin-4', 'cellular response to leukemia inhibitory factor', 'cellular senescence', 'circadian regulation of gene expression', 'common-partner SMAD protein phosphorylation', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'endoplasmic reticulum calcium ion homeostasis', 'entrainment of circadian clock by photoperiod', 'extrinsic apoptotic signaling pathway', 'fibroblast migration', 'innate immune response', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'intrinsic apoptotic signaling pathway in response to oxidative stress', 'maintenance of protein location in nucleus', 'myeloid cell differentiation', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of interleukin-1 beta production', 'negative regulation of mitotic cell cycle', 'negative regulation of telomerase activity', 'negative regulation of telomere maintenance via telomerase', 'negative regulation of transcription, DNA-templated', 'negative regulation of translation in response to oxidative stress', 'negative regulation of ubiquitin-dependent protein catabolic process', 'oncogene-induced cell senescence', 'PML body organization', 'positive regulation of apoptotic process involved in mammary gland involution', 'positive regulation of defense response to virus by host', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of fibroblast proliferation', 'positive regulation of histone deacetylation', 'positive regulation of peptidyl-lysine acetylation', 'positive regulation of protein localization to chromosome, telomeric region', 'positive regulation of signal transduction by p53 class mediator', 'positive regulation of telomere maintenance', 'positive regulation of transcription, DNA-templated', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein import into nucleus', 'protein stabilization', 'protein targeting', 'protein-containing complex assembly', 'protein-containing complex localization', 'regulation of calcium ion transport into cytosol', 'regulation of cell adhesion', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of double-strand break repair', 'regulation of transcription, DNA-templated', 'response to cytokine', 'response to gamma radiation', 'response to hypoxia', 'response to UV', 'retinoic acid receptor signaling pathway', 'suppression of viral release by host', 'transforming growth factor beta receptor signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'apoptotic process', 'branching involved in mammary gland duct morphogenesis', 'cell fate commitment', 'cellular response to interleukin-4', 'cellular response to leukemia inhibitory factor', 'cellular senescence', 'circadian regulation of gene expression', 'common-partner SMAD protein phosphorylation', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'endoplasmic reticulum calcium ion homeostasis', 'entrainment of circadian clock by photoperiod', 'extrinsic apoptotic signaling pathway', 'fibroblast migration', 'innate immune response', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'intrinsic apoptotic signaling pathway in response to oxidative stress', 'maintenance of protein location in nucleus', 'myeloid cell differentiation', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of interleukin-1 beta production', 'negative regulation of mitotic cell cycle', 'negative regulation of telomerase activity', 'negative regulation of telomere maintenance via telomerase', 'negative regulation of transcription, DNA-templated', 'negative regulation of translation in response to oxidative stress', 'negative regulation of ubiquitin-dependent protein catabolic process', 'oncogene-induced cell senescence', 'PML body organization', 'positive regulation of apoptotic process involved in mammary gland involution', 'positive regulation of defense response to virus by host', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of fibroblast proliferation', 'positive regulation of histone deacetylation', 'positive regulation of peptidyl-lysine acetylation', 'positive regulation of protein localization to chromosome, telomeric region', 'positive regulation of signal transduction by p53 class mediator', 'positive regulation of telomere maintenance', 'positive regulation of transcription, DNA-templated', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein import into nucleus', 'protein stabilization', 'protein targeting', 'protein-containing complex assembly', 'protein-containing complex localization', 'regulation of calcium ion transport into cytosol', 'regulation of cell adhesion', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of double-strand break repair', 'regulation of transcription, DNA-templated', 'response to cytokine', 'response to gamma radiation', 'response to hypoxia', 'response to UV', 'retinoic acid receptor signaling pathway', 'suppression of viral release by host', 'transforming growth factor beta receptor signaling pathway']
Liprin-alpha-2
113
Liprin-alpha-2
113
2.0
51
0.96
O75334O75334['cell-matrix adhesion', 'dense core granule cytoskeletal transport', 'regulation of dendritic spine development', 'regulation of dendritic spine morphogenesis', 'synapse organization']['cell-matrix adhesion', 'dense core granule cytoskeletal transport', 'regulation of dendritic spine development', 'regulation of dendritic spine morphogenesis', 'synapse organization']
Lysosomal protective protein
88
Lysosomal protective protein
362
2.0
73
0.67
P10619P10619['intracellular protein transport', 'negative regulation of chaperone-mediated autophagy', 'proteolysis', 'regulation of chaperone-mediated autophagy', 'regulation of protein stability']['intracellular protein transport', 'negative regulation of chaperone-mediated autophagy', 'proteolysis', 'regulation of chaperone-mediated autophagy', 'regulation of protein stability']
E3 ubiquitin-protein ligase RNF31
59
E3 ubiquitin-protein ligase RNF31
59
2.0
76
0.65
Q96EP0Q96EP0['CD40 signaling pathway', 'defense response to bacterium', 'negative regulation of necroptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of xenophagy', 'protein linear polyubiquitination', 'protein polyubiquitination', 'T cell receptor signaling pathway']['CD40 signaling pathway', 'defense response to bacterium', 'negative regulation of necroptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of xenophagy', 'protein linear polyubiquitination', 'protein polyubiquitination', 'T cell receptor signaling pathway']
Ig gamma-2A chain C region, A allele
107
Ig gamma-2A chain C region, A allele
107
2.0
31
1.58
P01863P01863['B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'response to bacterium']['B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'response to bacterium']
Transforming growth factor beta-1 proprotein
355
Transforming growth factor beta-1 proprotein
355
2.0
90
0.55
P01137P01137['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']
Acyloxyacyl hydrolase
123
Acyloxyacyl hydrolase
453
2.0
68
0.72
P28039P28039['fatty acid metabolic process', 'lipopolysaccharide catabolic process', 'negative regulation of inflammatory response']['fatty acid metabolic process', 'lipopolysaccharide catabolic process', 'negative regulation of inflammatory response']
Protein FosB
172
Protein FosB
172
2.0
50
0.98
P53539P53539['cellular response to calcium ion', 'cellular response to hormone stimulus', 'female pregnancy', 'negative regulation of transcription by RNA polymerase II', 'regulation of transcription by RNA polymerase II', 'response to cAMP', 'response to corticosterone', 'response to mechanical stimulus', 'response to morphine', 'response to progesterone', 'response to xenobiotic stimulus', 'transcription by RNA polymerase II']['cellular response to calcium ion', 'cellular response to hormone stimulus', 'female pregnancy', 'negative regulation of transcription by RNA polymerase II', 'regulation of transcription by RNA polymerase II', 'response to cAMP', 'response to corticosterone', 'response to mechanical stimulus', 'response to morphine', 'response to progesterone', 'response to xenobiotic stimulus', 'transcription by RNA polymerase II']
Glucocorticoid receptor
431
Glucocorticoid receptor
431
2.0
75
0.65
P04150P04150['adrenal gland development', 'apoptotic process', 'cell cycle', 'cell division', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin organization', 'chromosome segregation', 'glucocorticoid metabolic process', 'intracellular steroid hormone receptor signaling pathway', 'mammary gland duct morphogenesis', 'maternal behavior', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'signal transduction']['adrenal gland development', 'apoptotic process', 'cell cycle', 'cell division', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin organization', 'chromosome segregation', 'glucocorticoid metabolic process', 'intracellular steroid hormone receptor signaling pathway', 'mammary gland duct morphogenesis', 'maternal behavior', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'signal transduction']
B-cell antigen receptor complex-associated protein beta chain
136
B-cell antigen receptor complex-associated protein beta chain
136
2.0
75
0.65
P40259P40259['adaptive immune response', 'B cell differentiation', 'B cell receptor signaling pathway', 'immune response', 'signal transduction']['adaptive immune response', 'B cell differentiation', 'B cell receptor signaling pathway', 'immune response', 'signal transduction']
Growth/differentiation factor 2
392
Growth/differentiation factor 2
392
2.0
89
0.55
Q9UK05Q9UK05['activin receptor signaling pathway', 'angiogenesis', 'blood vessel morphogenesis', 'BMP signaling pathway', 'branching involved in blood vessel morphogenesis', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'negative regulation of angiogenesis', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell growth', 'negative regulation of DNA biosynthetic process', 'negative regulation of DNA replication', 'negative regulation of endothelial cell migration', 'negative regulation of endothelial cell proliferation', 'ossification', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of angiogenesis', 'positive regulation of BMP signaling pathway', 'positive regulation of cartilage development', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of interleukin-8 production', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'SMAD protein signal transduction', 'transcription by RNA polymerase II', 'vasculogenesis']['activin receptor signaling pathway', 'angiogenesis', 'blood vessel morphogenesis', 'BMP signaling pathway', 'branching involved in blood vessel morphogenesis', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'negative regulation of angiogenesis', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell growth', 'negative regulation of DNA biosynthetic process', 'negative regulation of DNA replication', 'negative regulation of endothelial cell migration', 'negative regulation of endothelial cell proliferation', 'ossification', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of angiogenesis', 'positive regulation of BMP signaling pathway', 'positive regulation of cartilage development', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of interleukin-8 production', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'SMAD protein signal transduction', 'transcription by RNA polymerase II', 'vasculogenesis']
Adenylyl cyclase-associated protein 1
92
Adenylyl cyclase-associated protein 1
92
2.0
63
0.78
P40124P40124['actin cytoskeleton organization', 'ameboidal-type cell migration', 'cAMP-mediated signaling', 'cell morphogenesis', 'receptor-mediated endocytosis', 'regulation of adenylate cyclase activity']['actin cytoskeleton organization', 'ameboidal-type cell migration', 'cAMP-mediated signaling', 'cell morphogenesis', 'receptor-mediated endocytosis', 'regulation of adenylate cyclase activity']
Potassium channel subfamily K member 2
108
Potassium channel subfamily K member 2
108
2.0
41
1.2
O95069O95069['cardiac ventricle development', 'cellular response to hypoxia', 'cochlea development', 'G protein-coupled receptor signaling pathway', 'memory', 'negative regulation of cardiac muscle cell proliferation', 'negative regulation of DNA biosynthetic process', 'positive regulation of cell death', 'positive regulation of cellular response to hypoxia', 'potassium ion transmembrane transport', 'response to axon injury', 'response to mechanical stimulus', 'stabilization of membrane potential']['cardiac ventricle development', 'cellular response to hypoxia', 'cochlea development', 'G protein-coupled receptor signaling pathway', 'memory', 'negative regulation of cardiac muscle cell proliferation', 'negative regulation of DNA biosynthetic process', 'positive regulation of cell death', 'positive regulation of cellular response to hypoxia', 'potassium ion transmembrane transport', 'response to axon injury', 'response to mechanical stimulus', 'stabilization of membrane potential']
Meprin A subunit beta
305
Meprin A subunit beta
305
2.0
50
0.98
Q16820Q16820['inflammatory response', 'proteolysis', 'toxin transport']['inflammatory response', 'proteolysis', 'toxin transport']
Diphosphoinositol polyphosphate phosphohydrolase 2
130
Diphosphoinositol polyphosphate phosphohydrolase 2
130
2.0
51
0.96
Q8R2U6Q8R2U6["adenosine 5'-(hexahydrogen pentaphosphate) catabolic process", 'diadenosine hexaphosphate catabolic process', 'diadenosine pentaphosphate catabolic process', 'diphosphoinositol polyphosphate metabolic process']["adenosine 5'-(hexahydrogen pentaphosphate) catabolic process", 'diadenosine hexaphosphate catabolic process', 'diadenosine pentaphosphate catabolic process', 'diphosphoinositol polyphosphate metabolic process']
Huntingtin-interacting protein 1
430
Huntingtin-interacting protein 1
430
2.0
58
0.84
O00291O00291['actin filament organization', 'activation of cysteine-type endopeptidase activity involved in apoptotic process', 'apoptotic process', 'apoptotic signaling pathway', 'cell differentiation', 'clathrin coat assembly', 'clathrin-dependent endocytosis', 'endocytosis', 'neurotransmitter receptor transport', 'positive regulation of epidermal growth factor receptor signaling pathway', 'positive regulation of platelet-derived growth factor receptor-beta signaling pathway', 'positive regulation of protein kinase B signaling', 'positive regulation of receptor-mediated endocytosis', 'protein stabilization', 'regulation of apoptotic process', 'regulation of endocytosis']['actin filament organization', 'activation of cysteine-type endopeptidase activity involved in apoptotic process', 'apoptotic process', 'apoptotic signaling pathway', 'cell differentiation', 'clathrin coat assembly', 'clathrin-dependent endocytosis', 'endocytosis', 'neurotransmitter receptor transport', 'positive regulation of epidermal growth factor receptor signaling pathway', 'positive regulation of platelet-derived growth factor receptor-beta signaling pathway', 'positive regulation of protein kinase B signaling', 'positive regulation of receptor-mediated endocytosis', 'protein stabilization', 'regulation of apoptotic process', 'regulation of endocytosis']
Bifunctional peptidase and arginyl-hydroxylase JMJD5
232
Bifunctional peptidase and arginyl-hydroxylase JMJD5
232
2.0
65
0.75
Q8N371Q8N371['chromatin organization', 'circadian regulation of gene expression', 'G2/M transition of mitotic cell cycle', 'histone H3-K36 demethylation', 'negative regulation of transcription, DNA-templated', 'positive regulation of transcription, DNA-templated', 'protein destabilization', 'proteolysis']['chromatin organization', 'circadian regulation of gene expression', 'G2/M transition of mitotic cell cycle', 'histone H3-K36 demethylation', 'negative regulation of transcription, DNA-templated', 'positive regulation of transcription, DNA-templated', 'protein destabilization', 'proteolysis']
Transforming acidic coiled-coil-containing protein 3
621
Transforming acidic coiled-coil-containing protein 3
621
2.0
72
0.68
Q9JJ11Q9JJ11['astral microtubule organization', 'cell division', 'cell population proliferation', 'cerebral cortex development', 'cytoplasmic sequestering of transcription factor', 'hemopoiesis', 'interkinetic nuclear migration', 'metaphase/anaphase transition of mitotic cell cycle', 'microtubule cytoskeleton organization', 'microtubule cytoskeleton organization involved in mitosis', 'mitotic spindle organization', 'neurogenesis', 'regulation of cell cycle', 'regulation of microtubule-based process', 'regulation of mitotic spindle organization', 'response to hypoxia', 'stem cell proliferation']['astral microtubule organization', 'cell division', 'cell population proliferation', 'cerebral cortex development', 'cytoplasmic sequestering of transcription factor', 'hemopoiesis', 'interkinetic nuclear migration', 'metaphase/anaphase transition of mitotic cell cycle', 'microtubule cytoskeleton organization', 'microtubule cytoskeleton organization involved in mitosis', 'mitotic spindle organization', 'neurogenesis', 'regulation of cell cycle', 'regulation of microtubule-based process', 'regulation of mitotic spindle organization', 'response to hypoxia', 'stem cell proliferation']
Transcription regulator protein BACH2
20
Transcription regulator protein BACH2
20
2.0
72
0.68
Q9BYV9Q9BYV9['import into nucleus', 'negative regulation of transcription by RNA polymerase II', 'primary adaptive immune response involving T cells and B cells', 'regulation of transcription by RNA polymerase II']['import into nucleus', 'negative regulation of transcription by RNA polymerase II', 'primary adaptive immune response involving T cells and B cells', 'regulation of transcription by RNA polymerase II']
Oxidized purine nucleoside triphosphate hydrolase
134
Oxidized purine nucleoside triphosphate hydrolase
134
2.0
89
0.55
P53368P53368['aging', 'DNA protection', 'male gonad development', 'purine nucleoside catabolic process', 'response to cadmium ion']['aging', 'DNA protection', 'male gonad development', 'purine nucleoside catabolic process', 'response to cadmium ion']
Collagen alpha-1(IX) chain
766
Collagen alpha-3(IX) chain
529
2.0
72
0.68
P20849Q14050['animal organ morphogenesis', 'extracellular matrix organization']['extracellular matrix organization', 'female gonad development', 'male gonad development']
Fibrinogen beta chain
87
Fibrinogen gamma-B chain
43
2.0
93
0.53
P02676P12799['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'innate immune response', 'platelet aggregation', 'protein polymerization']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'platelet aggregation', 'protein polymerization']
Caspase-1
136
Caspase-1
362
2.0
59
0.83
P29466P29466['apoptotic process', 'cellular response to interferon-gamma', 'cellular response to lipopolysaccharide', 'cellular response to mechanical stimulus', 'cellular response to organic substance', 'cytokine precursor processing', 'defense response to virus', 'icosanoid biosynthetic process', 'osmosensory signaling pathway', 'pattern recognition receptor signaling pathway', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of tumor necrosis factor-mediated signaling pathway', 'protein autoprocessing', 'proteolysis', 'pyroptosis', 'regulation of apoptotic process', 'regulation of inflammatory response', 'signal transduction', 'signaling receptor ligand precursor processing']['apoptotic process', 'cellular response to interferon-gamma', 'cellular response to lipopolysaccharide', 'cellular response to mechanical stimulus', 'cellular response to organic substance', 'cytokine precursor processing', 'defense response to virus', 'icosanoid biosynthetic process', 'osmosensory signaling pathway', 'pattern recognition receptor signaling pathway', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of tumor necrosis factor-mediated signaling pathway', 'protein autoprocessing', 'proteolysis', 'pyroptosis', 'regulation of apoptotic process', 'regulation of inflammatory response', 'signal transduction', 'signaling receptor ligand precursor processing']
Hemoglobin subunit beta
113
Hemoglobin subunit beta
113
2.0
89
0.55
P68871P68871['carbon dioxide transport', 'cellular oxidant detoxification', 'hydrogen peroxide catabolic process', 'nitric oxide transport', 'oxygen transport', 'platelet aggregation', 'positive regulation of cell death', 'positive regulation of nitric oxide biosynthetic process', 'regulation of blood pressure', 'renal absorption', 'response to hydrogen peroxide']['carbon dioxide transport', 'cellular oxidant detoxification', 'hydrogen peroxide catabolic process', 'nitric oxide transport', 'oxygen transport', 'platelet aggregation', 'positive regulation of cell death', 'positive regulation of nitric oxide biosynthetic process', 'regulation of blood pressure', 'renal absorption', 'response to hydrogen peroxide']
Asparagine synthetase [glutamine-hydrolyzing]
18
Asparagine synthetase [glutamine-hydrolyzing]
18
2.0
88
0.55
P08243P08243['asparagine biosynthetic process', 'cellular response to glucose starvation', 'glutamine metabolic process', 'L-asparagine biosynthetic process', 'negative regulation of apoptotic process', 'positive regulation of mitotic cell cycle']['asparagine biosynthetic process', 'cellular response to glucose starvation', 'glutamine metabolic process', 'L-asparagine biosynthetic process', 'negative regulation of apoptotic process', 'positive regulation of mitotic cell cycle']
Translationally-controlled tumor protein
172
Translationally-controlled tumor protein
172
2.0
nan
nan
P13693P13693['calcium ion transport', 'cellular calcium ion homeostasis', 'negative regulation of apoptotic process', 'negative regulation of ectoderm development', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'regulation of apoptotic process', 'response to virus', 'stem cell population maintenance']['calcium ion transport', 'cellular calcium ion homeostasis', 'negative regulation of apoptotic process', 'negative regulation of ectoderm development', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'regulation of apoptotic process', 'response to virus', 'stem cell population maintenance']
DNA polymerase lambda
543
DNA polymerase lambda
543
2.0
39
1.25
Q9UGP5Q9UGP5['base-excision repair, gap-filling', 'DNA biosynthetic process', 'DNA replication', 'double-strand break repair via homologous recombination', 'double-strand break repair via nonhomologous end joining', 'nucleotide-excision repair', 'somatic hypermutation of immunoglobulin genes']['base-excision repair, gap-filling', 'DNA biosynthetic process', 'DNA replication', 'double-strand break repair via homologous recombination', 'double-strand break repair via nonhomologous end joining', 'nucleotide-excision repair', 'somatic hypermutation of immunoglobulin genes']
Complement C5
567
Complement C5
810
2.0
72
0.68
P01031P01031['cell surface receptor signaling pathway', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'G protein-coupled receptor signaling pathway', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']['cell surface receptor signaling pathway', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'G protein-coupled receptor signaling pathway', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']
Double-strand break repair protein MRE11
146
Double-strand break repair protein MRE11
146
2.0
50
0.98
P49959P49959['cell population proliferation', 'cellular response to DNA damage stimulus', 'DNA double-strand break processing', 'DNA duplex unwinding', 'DNA recombination', 'DNA repair', 'DNA strand resection involved in replication fork processing', 'double-strand break repair', 'double-strand break repair via homologous recombination', 'double-strand break repair via nonhomologous end joining', 'homologous chromosome pairing at meiosis', 'homologous recombination', 'meiotic DNA double-strand break formation', 'mitochondrial double-strand break repair via homologous recombination', 'mitotic G2 DNA damage checkpoint signaling', 'mitotic G2/M transition checkpoint', 'mitotic intra-S DNA damage checkpoint signaling', 'negative regulation of apoptotic process', 'positive regulation of kinase activity', 'positive regulation of protein autophosphorylation', 'positive regulation of telomere maintenance', 'reciprocal meiotic recombination', 'regulation of mitotic recombination', 'sister chromatid cohesion', 'telomere maintenance', 'telomere maintenance via telomerase', "telomeric 3' overhang formation"]['cell population proliferation', 'cellular response to DNA damage stimulus', 'DNA double-strand break processing', 'DNA duplex unwinding', 'DNA recombination', 'DNA repair', 'DNA strand resection involved in replication fork processing', 'double-strand break repair', 'double-strand break repair via homologous recombination', 'double-strand break repair via nonhomologous end joining', 'homologous chromosome pairing at meiosis', 'homologous recombination', 'meiotic DNA double-strand break formation', 'mitochondrial double-strand break repair via homologous recombination', 'mitotic G2 DNA damage checkpoint signaling', 'mitotic G2/M transition checkpoint', 'mitotic intra-S DNA damage checkpoint signaling', 'negative regulation of apoptotic process', 'positive regulation of kinase activity', 'positive regulation of protein autophosphorylation', 'positive regulation of telomere maintenance', 'reciprocal meiotic recombination', 'regulation of mitotic recombination', 'sister chromatid cohesion', 'telomere maintenance', 'telomere maintenance via telomerase', "telomeric 3' overhang formation"]
Nucleotide-binding oligomerization domain-containing protein 1
39
Nucleotide-binding oligomerization domain-containing protein 1
39
2.0
69
0.71
Q9Y239Q9Y239['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'apoptotic process', 'cellular response to muramyl dipeptide', 'defense response', 'defense response to bacterium', 'defense response to Gram-positive bacterium', 'detection of bacterium', 'detection of biotic stimulus', 'ERK1 and ERK2 cascade', 'I-kappaB kinase/NF-kappaB signaling', 'inflammatory response', 'innate immune response', 'intracellular signal transduction', 'JNK cascade', 'pattern recognition receptor signaling pathway', 'positive regulation of cell death', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of dendritic cell antigen processing and presentation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of JNK cascade', 'positive regulation of macrophage cytokine production', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of tumor necrosis factor production', 'positive regulation of xenophagy', 'regulation of apoptotic process', 'signal transduction', 'xenophagy']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'apoptotic process', 'cellular response to muramyl dipeptide', 'defense response', 'defense response to bacterium', 'defense response to Gram-positive bacterium', 'detection of bacterium', 'detection of biotic stimulus', 'ERK1 and ERK2 cascade', 'I-kappaB kinase/NF-kappaB signaling', 'inflammatory response', 'innate immune response', 'intracellular signal transduction', 'JNK cascade', 'pattern recognition receptor signaling pathway', 'positive regulation of cell death', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of dendritic cell antigen processing and presentation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of JNK cascade', 'positive regulation of macrophage cytokine production', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of tumor necrosis factor production', 'positive regulation of xenophagy', 'regulation of apoptotic process', 'signal transduction', 'xenophagy']
Gremlin-1
144
Gremlin-1
141
9.2
79
0.14
O60565O60565['animal organ morphogenesis', 'apoptotic process', 'cardiac muscle cell differentiation', 'cardiac muscle cell myoblast differentiation', 'cell migration involved in sprouting angiogenesis', 'cell morphogenesis', 'cell-cell signaling', 'collagen fibril organization', 'determination of dorsal identity', 'embryonic limb morphogenesis', 'limb development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'negative regulation of apoptotic process', 'negative regulation of BMP signaling pathway', 'negative regulation of bone mineralization', 'negative regulation of bone mineralization involved in bone maturation', 'negative regulation of bone remodeling', 'negative regulation of bone trabecula formation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell growth', 'negative regulation of chondrocyte differentiation', 'negative regulation of monocyte chemotaxis', 'negative regulation of osteoblast differentiation', 'negative regulation of osteoblast proliferation', 'negative regulation of osteoclast proliferation', 'negative regulation of pathway-restricted SMAD protein phosphorylation', 'negative regulation of transcription, DNA-templated', 'positive regulation of angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell population proliferation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of receptor internalization', 'positive regulation of signaling receptor activity', 'positive regulation of telomerase activity', 'positive regulation of transcription by RNA polymerase II', 'proximal/distal pattern formation', 'regulation of epithelial to mesenchymal transition', 'regulation of focal adhesion assembly', 'sequestering of BMP from receptor via BMP binding', 'signal transduction', 'ureteric bud formation']['animal organ morphogenesis', 'apoptotic process', 'cardiac muscle cell differentiation', 'cardiac muscle cell myoblast differentiation', 'cell migration involved in sprouting angiogenesis', 'cell morphogenesis', 'cell-cell signaling', 'collagen fibril organization', 'determination of dorsal identity', 'embryonic limb morphogenesis', 'limb development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'negative regulation of apoptotic process', 'negative regulation of BMP signaling pathway', 'negative regulation of bone mineralization', 'negative regulation of bone mineralization involved in bone maturation', 'negative regulation of bone remodeling', 'negative regulation of bone trabecula formation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell growth', 'negative regulation of chondrocyte differentiation', 'negative regulation of monocyte chemotaxis', 'negative regulation of osteoblast differentiation', 'negative regulation of osteoblast proliferation', 'negative regulation of osteoclast proliferation', 'negative regulation of pathway-restricted SMAD protein phosphorylation', 'negative regulation of transcription, DNA-templated', 'positive regulation of angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell population proliferation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of receptor internalization', 'positive regulation of signaling receptor activity', 'positive regulation of telomerase activity', 'positive regulation of transcription by RNA polymerase II', 'proximal/distal pattern formation', 'regulation of epithelial to mesenchymal transition', 'regulation of focal adhesion assembly', 'sequestering of BMP from receptor via BMP binding', 'signal transduction', 'ureteric bud formation']
Protein ERGIC-53
198
Protein ERGIC-53
198
9.7
73
0.14
Q62902Q62902['endoplasmic reticulum organization', 'endoplasmic reticulum to Golgi vesicle-mediated transport', 'Golgi organization', 'positive regulation of organelle organization', 'protein transport']['endoplasmic reticulum organization', 'endoplasmic reticulum to Golgi vesicle-mediated transport', 'Golgi organization', 'positive regulation of organelle organization', 'protein transport']
Protein cereblon
329
Protein cereblon
394
9.2
82
0.13
Q8C7D2Q8C7D2['locomotory exploration behavior', 'negative regulation of ion transmembrane transport', 'negative regulation of large conductance calcium-activated potassium channel activity', 'negative regulation of protein-containing complex assembly', 'positive regulation of protein-containing complex assembly', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination']['locomotory exploration behavior', 'negative regulation of ion transmembrane transport', 'negative regulation of large conductance calcium-activated potassium channel activity', 'negative regulation of protein-containing complex assembly', 'positive regulation of protein-containing complex assembly', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination']
Suppressor of tumorigenicity 14 protein
641
Kunitz-type protease inhibitor 1
283
9.2
89
0.12
Q9Y5Y6O43278['epithelial cell morphogenesis involved in placental branching', 'keratinocyte differentiation', 'neural tube closure', 'protein catabolic process', 'proteolysis']['branching involved in labyrinthine layer morphogenesis', 'cellular response to BMP stimulus', 'epidermis development', 'epithelium development', 'extracellular matrix organization', 'negative regulation of neural precursor cell proliferation', 'neural tube closure', 'placenta blood vessel development', 'positive regulation of glial cell differentiation']
Pyruvate kinase PKLR
360
Pyruvate kinase PKLR
74
9.2
77
0.14
P12928P12928['ATP biosynthetic process', 'carbohydrate metabolic process', 'cellular response to epinephrine stimulus', 'cellular response to insulin stimulus', 'glycolytic process', 'pyruvate biosynthetic process', 'response to ATP', 'response to cAMP', 'response to glucose', 'response to heat', 'response to hypoxia', 'response to lithium ion', 'response to metal ion', 'response to nutrient', 'response to other organism']['ATP biosynthetic process', 'carbohydrate metabolic process', 'cellular response to epinephrine stimulus', 'cellular response to insulin stimulus', 'glycolytic process', 'pyruvate biosynthetic process', 'response to ATP', 'response to cAMP', 'response to glucose', 'response to heat', 'response to hypoxia', 'response to lithium ion', 'response to metal ion', 'response to nutrient', 'response to other organism']
Cullin-5
188
Cullin-5
188
9.2
66
0.16
Q93034Q93034['ERBB2 signaling pathway', 'G1/S transition of mitotic cell cycle', 'intrinsic apoptotic signaling pathway', 'protein ubiquitination', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process']['ERBB2 signaling pathway', 'G1/S transition of mitotic cell cycle', 'intrinsic apoptotic signaling pathway', 'protein ubiquitination', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process']
Cellular tumor antigen p53
173
Cellular tumor antigen p53
173
9.2
66
0.17
P02340P02340['apoptotic process', 'autophagy', 'B cell lineage commitment', 'bone marrow development', 'cardiac muscle cell apoptotic process', 'cardiac septum morphogenesis', 'cell population proliferation', 'cellular response to actinomycin D', 'cellular response to DNA damage stimulus', 'cellular response to gamma radiation', 'cellular response to glucose starvation', 'cellular response to ionizing radiation', 'cellular response to reactive oxygen species', 'cellular response to UV', 'cellular response to UV-C', 'cellular response to xenobiotic stimulus', 'cellular senescence', 'central nervous system development', 'cerebellum development', 'chromatin assembly', 'chromosome organization', 'circadian behavior', 'circadian rhythm', 'determination of adult lifespan', 'DNA damage response, signal transduction by p53 class mediator', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator', 'double-strand break repair', 'embryo development ending in birth or egg hatching', 'embryonic organ development', 'entrainment of circadian clock by photoperiod', 'ER overload response', 'fibroblast proliferation', 'gastrulation', 'glial cell proliferation', 'glucose catabolic process to lactate via pyruvate', 'heart development', 'hematopoietic progenitor cell differentiation', 'hematopoietic stem cell differentiation', 'in utero embryonic development', 'interferon-gamma-mediated signaling pathway', 'intrinsic apoptotic signaling pathway by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'intrinsic apoptotic signaling pathway in response to hypoxia', 'mitochondrial DNA repair', 'mitophagy', 'mitotic G1 DNA damage checkpoint signaling', 'mRNA transcription', 'multicellular organism growth', 'necroptotic process', 'negative regulation of apoptotic process', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of DNA biosynthetic process', 'negative regulation of DNA replication', 'negative regulation of fibroblast proliferation', 'negative regulation of G1 to G0 transition', 'negative regulation of gene expression', 'negative regulation of glial cell proliferation', 'negative regulation of glucose catabolic process to lactate via pyruvate', 'negative regulation of miRNA maturation', 'negative regulation of mitophagy', 'negative regulation of mitotic cell cycle', 'negative regulation of neuroblast proliferation', 'negative regulation of pentose-phosphate shunt', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of stem cell proliferation', 'negative regulation of telomerase activity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'neuroblast proliferation', 'neuron apoptotic process', 'nucleotide-excision repair', 'oligodendrocyte apoptotic process', 'oxidative stress-induced premature senescence', 'positive regulation of apoptotic process', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of cell cycle', 'positive regulation of cellular senescence', 'positive regulation of execution phase of apoptosis', 'positive regulation of gene expression', 'positive regulation of histone deacetylation', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of leukocyte migration', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of mitochondrial membrane permeability', 'positive regulation of neuron apoptotic process', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of programmed necrotic cell death', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of release of cytochrome c from mitochondria', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of thymocyte apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription from RNA polymerase II promoter in response to stress', 'positive regulation of transcription, DNA-templated', 'protein import into nucleus', 'protein localization', 'protein stabilization', 'protein tetramerization', 'protein-containing complex assembly', 'Ras protein signal transduction', 'reactive oxygen species metabolic process', 'regulation of apoptotic process', 'regulation of cell cycle', 'regulation of cell cycle G2/M phase transition', 'regulation of cell population proliferation', 'regulation of cellular senescence', 'regulation of DNA damage response, signal transduction by p53 class mediator', 'regulation of fibroblast apoptotic process', 'regulation of hydrogen peroxide-induced cell death', 'regulation of intracellular pH', 'regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'regulation of mitochondrial membrane permeability involved in apoptotic process', 'regulation of mitotic cell cycle', 'regulation of neuron apoptotic process', 'regulation of thymocyte apoptotic process', 'regulation of tissue remodeling', 'regulation of transcription by RNA polymerase II', 'regulation of transcription from RNA polymerase II promoter in response to DNA damage', 'regulation of transcription, DNA-templated', 'release of cytochrome c from mitochondria', 'replicative senescence', 'response to gamma radiation', 'response to ischemia', 'response to oxidative stress', 'response to salt stress', 'response to UV', 'response to X-ray', 'response to xenobiotic stimulus', 'rRNA transcription', 'signal transduction by p53 class mediator', 'somitogenesis', 'spermatogenesis', 'stem cell proliferation', 'T cell differentiation in thymus', 'T cell lineage commitment', 'T cell proliferation involved in immune response', 'thymocyte apoptotic process', 'transforming growth factor beta receptor signaling pathway', 'tumor necrosis factor-mediated signaling pathway', 'viral process']['apoptotic process', 'autophagy', 'B cell lineage commitment', 'bone marrow development', 'cardiac muscle cell apoptotic process', 'cardiac septum morphogenesis', 'cell population proliferation', 'cellular response to actinomycin D', 'cellular response to DNA damage stimulus', 'cellular response to gamma radiation', 'cellular response to glucose starvation', 'cellular response to ionizing radiation', 'cellular response to reactive oxygen species', 'cellular response to UV', 'cellular response to UV-C', 'cellular response to xenobiotic stimulus', 'cellular senescence', 'central nervous system development', 'cerebellum development', 'chromatin assembly', 'chromosome organization', 'circadian behavior', 'circadian rhythm', 'determination of adult lifespan', 'DNA damage response, signal transduction by p53 class mediator', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator', 'double-strand break repair', 'embryo development ending in birth or egg hatching', 'embryonic organ development', 'entrainment of circadian clock by photoperiod', 'ER overload response', 'fibroblast proliferation', 'gastrulation', 'glial cell proliferation', 'glucose catabolic process to lactate via pyruvate', 'heart development', 'hematopoietic progenitor cell differentiation', 'hematopoietic stem cell differentiation', 'in utero embryonic development', 'interferon-gamma-mediated signaling pathway', 'intrinsic apoptotic signaling pathway by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'intrinsic apoptotic signaling pathway in response to hypoxia', 'mitochondrial DNA repair', 'mitophagy', 'mitotic G1 DNA damage checkpoint signaling', 'mRNA transcription', 'multicellular organism growth', 'necroptotic process', 'negative regulation of apoptotic process', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of DNA biosynthetic process', 'negative regulation of DNA replication', 'negative regulation of fibroblast proliferation', 'negative regulation of G1 to G0 transition', 'negative regulation of gene expression', 'negative regulation of glial cell proliferation', 'negative regulation of glucose catabolic process to lactate via pyruvate', 'negative regulation of miRNA maturation', 'negative regulation of mitophagy', 'negative regulation of mitotic cell cycle', 'negative regulation of neuroblast proliferation', 'negative regulation of pentose-phosphate shunt', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of stem cell proliferation', 'negative regulation of telomerase activity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'neuroblast proliferation', 'neuron apoptotic process', 'nucleotide-excision repair', 'oligodendrocyte apoptotic process', 'oxidative stress-induced premature senescence', 'positive regulation of apoptotic process', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of cell cycle', 'positive regulation of cellular senescence', 'positive regulation of execution phase of apoptosis', 'positive regulation of gene expression', 'positive regulation of histone deacetylation', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of leukocyte migration', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of mitochondrial membrane permeability', 'positive regulation of neuron apoptotic process', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of programmed necrotic cell death', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of release of cytochrome c from mitochondria', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of thymocyte apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription from RNA polymerase II promoter in response to stress', 'positive regulation of transcription, DNA-templated', 'protein import into nucleus', 'protein localization', 'protein stabilization', 'protein tetramerization', 'protein-containing complex assembly', 'Ras protein signal transduction', 'reactive oxygen species metabolic process', 'regulation of apoptotic process', 'regulation of cell cycle', 'regulation of cell cycle G2/M phase transition', 'regulation of cell population proliferation', 'regulation of cellular senescence', 'regulation of DNA damage response, signal transduction by p53 class mediator', 'regulation of fibroblast apoptotic process', 'regulation of hydrogen peroxide-induced cell death', 'regulation of intracellular pH', 'regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'regulation of mitochondrial membrane permeability involved in apoptotic process', 'regulation of mitotic cell cycle', 'regulation of neuron apoptotic process', 'regulation of thymocyte apoptotic process', 'regulation of tissue remodeling', 'regulation of transcription by RNA polymerase II', 'regulation of transcription from RNA polymerase II promoter in response to DNA damage', 'regulation of transcription, DNA-templated', 'release of cytochrome c from mitochondria', 'replicative senescence', 'response to gamma radiation', 'response to ischemia', 'response to oxidative stress', 'response to salt stress', 'response to UV', 'response to X-ray', 'response to xenobiotic stimulus', 'rRNA transcription', 'signal transduction by p53 class mediator', 'somitogenesis', 'spermatogenesis', 'stem cell proliferation', 'T cell differentiation in thymus', 'T cell lineage commitment', 'T cell proliferation involved in immune response', 'thymocyte apoptotic process', 'transforming growth factor beta receptor signaling pathway', 'tumor necrosis factor-mediated signaling pathway', 'viral process']
DNA (cytosine-5)-methyltransferase 3A
562
DNA (cytosine-5)-methyltransferase 3A
514
9.2
82
0.13
Q9Y6K1Q9Y6K1['aging', 'C-5 methylation of cytosine', 'cellular response to amino acid stimulus', 'cellular response to bisphenol A', 'cellular response to ethanol', 'cellular response to hypoxia', 'DNA methylation', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'DNA methylation on cytosine', 'DNA methylation-dependent heterochromatin assembly', 'hepatocyte apoptotic process', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron differentiation', 'positive regulation of cell death', 'regulation of gene expression by genomic imprinting', 'response to cocaine', 'response to estradiol', 'response to ionizing radiation', 'response to lead ion', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'spermatogenesis']['aging', 'C-5 methylation of cytosine', 'cellular response to amino acid stimulus', 'cellular response to bisphenol A', 'cellular response to ethanol', 'cellular response to hypoxia', 'DNA methylation', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'DNA methylation on cytosine', 'DNA methylation-dependent heterochromatin assembly', 'hepatocyte apoptotic process', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron differentiation', 'positive regulation of cell death', 'regulation of gene expression by genomic imprinting', 'response to cocaine', 'response to estradiol', 'response to ionizing radiation', 'response to lead ion', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'spermatogenesis']
N-acetyltransferase ESCO1
758
N-acetyltransferase ESCO1
757
9.2
86
0.13
Q5FWF5Q5FWF5['mitotic sister chromatid cohesion', 'peptidyl-lysine acetylation', 'post-translational protein acetylation', 'regulation of DNA replication']['mitotic sister chromatid cohesion', 'peptidyl-lysine acetylation', 'post-translational protein acetylation', 'regulation of DNA replication']
NADP-dependent malic enzyme
556
NADP-dependent malic enzyme
556
9.2
48
0.23
P48163P48163['carbohydrate metabolic process', 'malate metabolic process', 'NADH metabolic process', 'NADP metabolic process', 'nucleotide biosynthetic process', 'protein homotetramerization', 'pyruvate metabolic process', 'regulation of NADP metabolic process', 'response to carbohydrate', 'response to hormone']['carbohydrate metabolic process', 'malate metabolic process', 'NADH metabolic process', 'NADP metabolic process', 'nucleotide biosynthetic process', 'protein homotetramerization', 'pyruvate metabolic process', 'regulation of NADP metabolic process', 'response to carbohydrate', 'response to hormone']
Norrin
96
Norrin
93
9.0
78
0.14
Q00604Q00604['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']
Nuclear receptor subfamily 1 group I member 3
233
Nuclear receptor subfamily 1 group I member 3
221
9.8
71
0.14
O35627O35627['cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'osteoblast differentiation', 'positive regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated']['cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'osteoblast differentiation', 'positive regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated']
40S ribosomal protein S20
70
40S ribosomal protein S29
39
9.0
50
0.22
G1SIZ2G1U7M4['translation']['translation']
Transforming growth factor beta-1 proprotein
355
Transforming growth factor beta-1 proprotein
326
9.0
75
0.15
P07200P07200['adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains', 'aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'branch elongation involved in mammary gland duct branching', 'bronchiole development', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'cellular calcium ion homeostasis', 'cellular response to ionizing radiation', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'chondrocyte differentiation', 'columnar/cuboidal epithelial cell maturation', 'common-partner SMAD protein phosphorylation', 'embryonic liver development', 'enamel mineralization', 'endoderm development', 'epidermal growth factor receptor signaling pathway', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'face morphogenesis', 'gene expression', 'germ cell migration', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'Langerhans cell differentiation', 'lens fiber cell differentiation', 'lipopolysaccharide-mediated signaling pathway', 'lung alveolus development', 'lymph node development', 'mammary gland branching involved in thelarche', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'muscle cell cellular homeostasis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of epithelial cell proliferation', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of interleukin-17 production', 'negative regulation of macrophage cytokine production', 'negative regulation of myoblast differentiation', 'negative regulation of ossification', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of T cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'Notch signaling pathway', 'oligodendrocyte development', 'ossification involved in bone remodeling', 'osteoclast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'phospholipid homeostasis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of histone acetylation', 'positive regulation of histone deacetylation', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of odontogenesis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor clustering', 'positive regulation of regulatory T cell differentiation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stem cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of actin cytoskeleton reorganization', 'regulation of binding', 'regulation of branching involved in mammary gland duct morphogenesis', 'regulation of cartilage development', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of interleukin-23 production', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of sodium ion transport', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulatory T cell differentiation', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'stem cell proliferation', 'surfactant homeostasis', 'T cell homeostasis', 'T cell proliferation', 'tolerance induction to self antigen', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'ureteric bud development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains', 'aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'branch elongation involved in mammary gland duct branching', 'bronchiole development', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'cellular calcium ion homeostasis', 'cellular response to ionizing radiation', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'chondrocyte differentiation', 'columnar/cuboidal epithelial cell maturation', 'common-partner SMAD protein phosphorylation', 'embryonic liver development', 'enamel mineralization', 'endoderm development', 'epidermal growth factor receptor signaling pathway', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'face morphogenesis', 'gene expression', 'germ cell migration', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'Langerhans cell differentiation', 'lens fiber cell differentiation', 'lipopolysaccharide-mediated signaling pathway', 'lung alveolus development', 'lymph node development', 'mammary gland branching involved in thelarche', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'muscle cell cellular homeostasis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of epithelial cell proliferation', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of interleukin-17 production', 'negative regulation of macrophage cytokine production', 'negative regulation of myoblast differentiation', 'negative regulation of ossification', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of T cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'Notch signaling pathway', 'oligodendrocyte development', 'ossification involved in bone remodeling', 'osteoclast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'phospholipid homeostasis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of histone acetylation', 'positive regulation of histone deacetylation', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of odontogenesis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor clustering', 'positive regulation of regulatory T cell differentiation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stem cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of actin cytoskeleton reorganization', 'regulation of binding', 'regulation of branching involved in mammary gland duct morphogenesis', 'regulation of cartilage development', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of interleukin-23 production', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of sodium ion transport', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulatory T cell differentiation', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'stem cell proliferation', 'surfactant homeostasis', 'T cell homeostasis', 'T cell proliferation', 'tolerance induction to self antigen', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'ureteric bud development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']
C-X-C motif chemokine 10
30
C-X-C motif chemokine 10
30
9.0
64
0.17
P17515P17515['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'antiviral innate immune response', 'cellular response to interleukin-17', 'cellular response to lipopolysaccharide', 'cellular response to virus', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response to virus', 'endothelial cell activation', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'killing of cells of another organism', 'negative regulation of angiogenesis', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast fusion', 'neutrophil chemotaxis', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of leukocyte chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of release of sequestered calcium ion into cytosol', 'positive regulation of T cell migration', 'regulation of apoptotic process', 'regulation of cell population proliferation', 'regulation of endothelial tube morphogenesis', 'regulation of T cell chemotaxis', 'response to bacterium', 'T cell chemotaxis']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'antiviral innate immune response', 'cellular response to interleukin-17', 'cellular response to lipopolysaccharide', 'cellular response to virus', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response to virus', 'endothelial cell activation', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'killing of cells of another organism', 'negative regulation of angiogenesis', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast fusion', 'neutrophil chemotaxis', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of leukocyte chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of release of sequestered calcium ion into cytosol', 'positive regulation of T cell migration', 'regulation of apoptotic process', 'regulation of cell population proliferation', 'regulation of endothelial tube morphogenesis', 'regulation of T cell chemotaxis', 'response to bacterium', 'T cell chemotaxis']
Amyloid-beta precursor protein
98
Amyloid-beta precursor protein
98
9.0
81
0.14
P05067P05067['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Prorelaxin H2
176
Prorelaxin H2
35
9.8
54
0.19
P04090P04090['female pregnancy', 'positive regulation of angiogenesis', 'positive regulation of gene expression', 'regulation of catalytic activity']['female pregnancy', 'positive regulation of angiogenesis', 'positive regulation of gene expression', 'regulation of catalytic activity']
Vascular endothelial growth factor A
77
Vascular endothelial growth factor A
87
9.0
75
0.15
Q96NW5Q96NW5['activation of protein kinase activity', 'angiogenesis', 'artery morphogenesis', 'basophil chemotaxis', 'branching involved in blood vessel morphogenesis', 'camera-type eye morphogenesis', 'cardiac muscle cell development', 'cardiac vascular smooth muscle cell development', 'cell maturation', 'cell migration involved in sprouting angiogenesis', 'cellular response to hypoxia', 'cellular response to vascular endothelial growth factor stimulus', 'cellular stress response to acid chemical', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'coronary vein morphogenesis', 'dopaminergic neuron differentiation', 'endothelial cell chemotaxis', 'epithelial cell differentiation', 'eye photoreceptor cell development', 'heart morphogenesis', 'in utero embryonic development', 'induction of positive chemotaxis', 'kidney development', 'lactation', 'lung development', 'lymph vessel morphogenesis', 'macrophage differentiation', 'mammary gland alveolus development', 'mesoderm development', 'monocyte differentiation', 'motor neuron migration', 'negative regulation of adherens junction organization', 'negative regulation of apoptotic process', 'negative regulation of blood-brain barrier permeability', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of establishment of endothelial barrier', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'outflow tract morphogenesis', 'ovarian follicle development', 'positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell migration by vascular endothelial growth factor signaling pathway', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway', 'positive regulation of cold-induced thermogenesis', 'positive regulation of CREB transcription factor activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of histone deacetylase activity', 'positive regulation of leukocyte migration', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of neuroblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of positive chemotaxis', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C signaling', 'positive regulation of protein kinase D signaling', 'positive regulation of protein localization to early endosome', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor internalization', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of trophoblast cell migration', 'positive regulation of vascular permeability', 'post-embryonic camera-type eye development', 'primitive erythrocyte differentiation', 'regulation of cell shape', 'regulation of nitric oxide mediated signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of transcription by RNA polymerase II', 'response to hypoxia', 'sprouting angiogenesis', 'surfactant homeostasis', 'tube formation', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway']['activation of protein kinase activity', 'angiogenesis', 'artery morphogenesis', 'basophil chemotaxis', 'branching involved in blood vessel morphogenesis', 'camera-type eye morphogenesis', 'cardiac muscle cell development', 'cardiac vascular smooth muscle cell development', 'cell maturation', 'cell migration involved in sprouting angiogenesis', 'cellular response to hypoxia', 'cellular response to vascular endothelial growth factor stimulus', 'cellular stress response to acid chemical', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'coronary vein morphogenesis', 'dopaminergic neuron differentiation', 'endothelial cell chemotaxis', 'epithelial cell differentiation', 'eye photoreceptor cell development', 'heart morphogenesis', 'in utero embryonic development', 'induction of positive chemotaxis', 'kidney development', 'lactation', 'lung development', 'lymph vessel morphogenesis', 'macrophage differentiation', 'mammary gland alveolus development', 'mesoderm development', 'monocyte differentiation', 'motor neuron migration', 'negative regulation of adherens junction organization', 'negative regulation of apoptotic process', 'negative regulation of blood-brain barrier permeability', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of establishment of endothelial barrier', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'outflow tract morphogenesis', 'ovarian follicle development', 'positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell migration by vascular endothelial growth factor signaling pathway', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway', 'positive regulation of cold-induced thermogenesis', 'positive regulation of CREB transcription factor activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of histone deacetylase activity', 'positive regulation of leukocyte migration', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of neuroblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of positive chemotaxis', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C signaling', 'positive regulation of protein kinase D signaling', 'positive regulation of protein localization to early endosome', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor internalization', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of trophoblast cell migration', 'positive regulation of vascular permeability', 'post-embryonic camera-type eye development', 'primitive erythrocyte differentiation', 'regulation of cell shape', 'regulation of nitric oxide mediated signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of transcription by RNA polymerase II', 'response to hypoxia', 'sprouting angiogenesis', 'surfactant homeostasis', 'tube formation', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway']
EKC/KEOPS complex subunit TPRKB
167
EKC/KEOPS complex subunit TP53RK
91
9.0
89
0.12
Q9Y3C4Q96S44['telomere maintenance via recombination', 'tRNA threonylcarbamoyladenosine modification']['protein phosphorylation', 'regulation of signal transduction by p53 class mediator', 'tRNA processing', 'tRNA threonylcarbamoyladenosine metabolic process']
Growth/differentiation factor 2
393
Growth/differentiation factor 2
392
9.0
83
0.13
Q9UK05Q9UK05['activin receptor signaling pathway', 'angiogenesis', 'blood vessel morphogenesis', 'BMP signaling pathway', 'branching involved in blood vessel morphogenesis', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'negative regulation of angiogenesis', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell growth', 'negative regulation of DNA biosynthetic process', 'negative regulation of DNA replication', 'negative regulation of endothelial cell migration', 'negative regulation of endothelial cell proliferation', 'ossification', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of angiogenesis', 'positive regulation of BMP signaling pathway', 'positive regulation of cartilage development', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of interleukin-8 production', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'SMAD protein signal transduction', 'transcription by RNA polymerase II', 'vasculogenesis']['activin receptor signaling pathway', 'angiogenesis', 'blood vessel morphogenesis', 'BMP signaling pathway', 'branching involved in blood vessel morphogenesis', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'negative regulation of angiogenesis', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell growth', 'negative regulation of DNA biosynthetic process', 'negative regulation of DNA replication', 'negative regulation of endothelial cell migration', 'negative regulation of endothelial cell proliferation', 'ossification', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of angiogenesis', 'positive regulation of BMP signaling pathway', 'positive regulation of cartilage development', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of interleukin-8 production', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'SMAD protein signal transduction', 'transcription by RNA polymerase II', 'vasculogenesis']
4-trimethylaminobutyraldehyde dehydrogenase
484
4-trimethylaminobutyraldehyde dehydrogenase
289
9.7
94
0.11
P49189P49189['carnitine biosynthetic process', 'cellular aldehyde metabolic process', 'hormone metabolic process', 'neurotransmitter biosynthetic process', 'protein homotetramerization']['carnitine biosynthetic process', 'cellular aldehyde metabolic process', 'hormone metabolic process', 'neurotransmitter biosynthetic process', 'protein homotetramerization']
Transforming growth factor beta-2 proprotein
379
Transforming growth factor beta-2 proprotein
380
9.2
78
0.14
P61812P61812['activation of protein kinase activity', 'ascending aorta morphogenesis', 'atrial septum morphogenesis', 'atrial septum primum morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'cardiac epithelial to mesenchymal transition', 'cardiac muscle cell proliferation', 'cardiac right ventricle morphogenesis', 'cardioblast differentiation', 'cell death', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'collagen fibril organization', 'cranial skeletal system development', 'dopamine biosynthetic process', 'embryo development ending in birth or egg hatching', 'embryonic digestive tract development', 'embryonic limb morphogenesis', 'endocardial cushion fusion', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'extrinsic apoptotic signaling pathway', 'eye development', 'generation of neurons', 'glial cell migration', 'hair follicle development', 'hair follicle morphogenesis', 'heart development', 'heart morphogenesis', 'heart valve morphogenesis', 'hemopoiesis', 'inner ear development', 'kidney development', 'male gonad development', 'membranous septum morphogenesis', 'negative regulation of alkaline phosphatase activity', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'negative regulation of gene expression', 'negative regulation of macrophage cytokine production', 'negative regulation of Ras protein signal transduction', 'neural retina development', 'neural tube closure', 'neuron development', 'neutrophil chemotaxis', 'odontogenesis', 'outflow tract septum morphogenesis', 'pathway-restricted SMAD protein phosphorylation', 'pharyngeal arch artery morphogenesis', 'positive regulation of cardioblast differentiation', 'positive regulation of cell adhesion mediated by integrin', 'positive regulation of cell cycle', 'positive regulation of cell division', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'positive regulation of heart contraction', 'positive regulation of immune response', 'positive regulation of integrin biosynthetic process', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of Notch signaling pathway', 'positive regulation of ossification', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of stress-activated MAPK cascade', 'positive regulation of timing of catagen', 'protein phosphorylation', 'pulmonary valve morphogenesis', 'regulation of apoptotic process involved in outflow tract morphogenesis', 'regulation of cell population proliferation', 'regulation of timing of catagen', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to progesterone', 'response to wounding', 'response to xenobiotic stimulus', 'salivary gland morphogenesis', 'secondary palate development', 'skeletal system development', 'SMAD protein signal transduction', 'somatic stem cell division', 'substantia propria of cornea development', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'uterus development', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis', 'wound healing']['activation of protein kinase activity', 'ascending aorta morphogenesis', 'atrial septum morphogenesis', 'atrial septum primum morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'cardiac epithelial to mesenchymal transition', 'cardiac muscle cell proliferation', 'cardiac right ventricle morphogenesis', 'cardioblast differentiation', 'cell death', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'collagen fibril organization', 'cranial skeletal system development', 'dopamine biosynthetic process', 'embryo development ending in birth or egg hatching', 'embryonic digestive tract development', 'embryonic limb morphogenesis', 'endocardial cushion fusion', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'extrinsic apoptotic signaling pathway', 'eye development', 'generation of neurons', 'glial cell migration', 'hair follicle development', 'hair follicle morphogenesis', 'heart development', 'heart morphogenesis', 'heart valve morphogenesis', 'hemopoiesis', 'inner ear development', 'kidney development', 'male gonad development', 'membranous septum morphogenesis', 'negative regulation of alkaline phosphatase activity', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'negative regulation of gene expression', 'negative regulation of macrophage cytokine production', 'negative regulation of Ras protein signal transduction', 'neural retina development', 'neural tube closure', 'neuron development', 'neutrophil chemotaxis', 'odontogenesis', 'outflow tract septum morphogenesis', 'pathway-restricted SMAD protein phosphorylation', 'pharyngeal arch artery morphogenesis', 'positive regulation of cardioblast differentiation', 'positive regulation of cell adhesion mediated by integrin', 'positive regulation of cell cycle', 'positive regulation of cell division', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation', 'positive regulation of heart contraction', 'positive regulation of immune response', 'positive regulation of integrin biosynthetic process', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of Notch signaling pathway', 'positive regulation of ossification', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of stress-activated MAPK cascade', 'positive regulation of timing of catagen', 'protein phosphorylation', 'pulmonary valve morphogenesis', 'regulation of apoptotic process involved in outflow tract morphogenesis', 'regulation of cell population proliferation', 'regulation of timing of catagen', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to progesterone', 'response to wounding', 'response to xenobiotic stimulus', 'salivary gland morphogenesis', 'secondary palate development', 'skeletal system development', 'SMAD protein signal transduction', 'somatic stem cell division', 'substantia propria of cornea development', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'uterus development', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis', 'wound healing']
DNA polymerase zeta catalytic subunit
1999
DNA polymerase zeta catalytic subunit
1999
9.2
71
0.15
O60673O60673['DNA-templated DNA replication', 'double-strand break repair via homologous recombination', 'error-prone translesion synthesis']['DNA-templated DNA replication', 'double-strand break repair via homologous recombination', 'error-prone translesion synthesis']
C-C motif chemokine 16
37
C-C motif chemokine 16
38
9.2
75
0.14
O15467O15467['cell communication', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']['cell communication', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']
Bone morphogenetic protein 2
360
Bone morphogenetic protein 2
296
9.7
71
0.14
P12643P12643['ameloblast differentiation', 'animal organ morphogenesis', 'aortic valve development', 'astrocyte differentiation', 'atrioventricular canal morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'BMP signaling pathway involved in heart development', 'BMP signaling pathway involved in heart induction', 'bone mineralization', 'bone mineralization involved in bone maturation', 'branching involved in ureteric bud morphogenesis', 'cardiac atrium formation', 'cardiac epithelial to mesenchymal transition', 'cardiac jelly development', 'cardiac muscle cell differentiation', 'cardiac muscle tissue morphogenesis', 'cardiocyte differentiation', 'cell fate commitment', 'cell-cell signaling', 'cellular response to BMP stimulus', 'cellular response to organic cyclic compound', 'chondrocyte differentiation', 'corticotropin hormone secreting cell differentiation', 'embryonic heart tube anterior/posterior pattern specification', 'endocardial cushion formation', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'heart development', 'in utero embryonic development', 'inflammatory response', 'inner ear development', 'mesenchymal cell differentiation', 'mesenchymal cell proliferation involved in ureteric bud development', 'mesenchyme development', 'negative regulation of aldosterone biosynthetic process', 'negative regulation of calcium-independent cell-cell adhesion', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cardiac muscle cell differentiation', 'negative regulation of cell cycle', 'negative regulation of cell population proliferation', 'negative regulation of cortisol biosynthetic process', 'negative regulation of gene expression', 'negative regulation of insulin-like growth factor receptor signaling pathway', 'negative regulation of MAP kinase activity', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of steroid biosynthetic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of Wnt signaling pathway involved in heart development', 'Notch signaling pathway', 'odontogenesis of dentin-containing tooth', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'pericardium development', 'positive regulation of apoptotic process', 'positive regulation of astrocyte differentiation', 'positive regulation of bone mineralization', 'positive regulation of cartilage development', 'positive regulation of cell migration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell differentiation', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix constituent secretion', 'positive regulation of fat cell differentiation', 'positive regulation of gene expression', 'positive regulation of MAPK cascade', 'positive regulation of miRNA transcription', 'positive regulation of neuron differentiation', 'positive regulation of odontogenesis', 'positive regulation of ossification', 'positive regulation of osteoblast differentiation', 'positive regulation of osteoblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peroxisome proliferator activated receptor signaling pathway', 'positive regulation of phosphatase activity', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus', 'positive regulation of transcription, DNA-templated', 'positive regulation of Wnt signaling pathway', 'positive regulation of Wnt signaling pathway by BMP signaling pathway', 'protein destabilization', 'protein phosphorylation', 'proteoglycan metabolic process', 'regulation of odontogenesis of dentin-containing tooth', 'regulation of transcription, DNA-templated', 'response to bacterium', 'response to hypoxia', 'skeletal system development', 'SMAD protein signal transduction', 'telencephalon development', 'telencephalon regionalization', 'thyroid-stimulating hormone-secreting cell differentiation', 'transcription by RNA polymerase II', 'Wnt signaling pathway']['ameloblast differentiation', 'animal organ morphogenesis', 'aortic valve development', 'astrocyte differentiation', 'atrioventricular canal morphogenesis', 'atrioventricular valve morphogenesis', 'BMP signaling pathway', 'BMP signaling pathway involved in heart development', 'BMP signaling pathway involved in heart induction', 'bone mineralization', 'bone mineralization involved in bone maturation', 'branching involved in ureteric bud morphogenesis', 'cardiac atrium formation', 'cardiac epithelial to mesenchymal transition', 'cardiac jelly development', 'cardiac muscle cell differentiation', 'cardiac muscle tissue morphogenesis', 'cardiocyte differentiation', 'cell fate commitment', 'cell-cell signaling', 'cellular response to BMP stimulus', 'cellular response to organic cyclic compound', 'chondrocyte differentiation', 'corticotropin hormone secreting cell differentiation', 'embryonic heart tube anterior/posterior pattern specification', 'endocardial cushion formation', 'endocardial cushion morphogenesis', 'epithelial to mesenchymal transition', 'heart development', 'in utero embryonic development', 'inflammatory response', 'inner ear development', 'mesenchymal cell differentiation', 'mesenchymal cell proliferation involved in ureteric bud development', 'mesenchyme development', 'negative regulation of aldosterone biosynthetic process', 'negative regulation of calcium-independent cell-cell adhesion', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cardiac muscle cell differentiation', 'negative regulation of cell cycle', 'negative regulation of cell population proliferation', 'negative regulation of cortisol biosynthetic process', 'negative regulation of gene expression', 'negative regulation of insulin-like growth factor receptor signaling pathway', 'negative regulation of MAP kinase activity', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of steroid biosynthetic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of Wnt signaling pathway involved in heart development', 'Notch signaling pathway', 'odontogenesis of dentin-containing tooth', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'pericardium development', 'positive regulation of apoptotic process', 'positive regulation of astrocyte differentiation', 'positive regulation of bone mineralization', 'positive regulation of cartilage development', 'positive regulation of cell migration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell differentiation', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix constituent secretion', 'positive regulation of fat cell differentiation', 'positive regulation of gene expression', 'positive regulation of MAPK cascade', 'positive regulation of miRNA transcription', 'positive regulation of neuron differentiation', 'positive regulation of odontogenesis', 'positive regulation of ossification', 'positive regulation of osteoblast differentiation', 'positive regulation of osteoblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peroxisome proliferator activated receptor signaling pathway', 'positive regulation of phosphatase activity', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus', 'positive regulation of transcription, DNA-templated', 'positive regulation of Wnt signaling pathway', 'positive regulation of Wnt signaling pathway by BMP signaling pathway', 'protein destabilization', 'protein phosphorylation', 'proteoglycan metabolic process', 'regulation of odontogenesis of dentin-containing tooth', 'regulation of transcription, DNA-templated', 'response to bacterium', 'response to hypoxia', 'skeletal system development', 'SMAD protein signal transduction', 'telencephalon development', 'telencephalon regionalization', 'thyroid-stimulating hormone-secreting cell differentiation', 'transcription by RNA polymerase II', 'Wnt signaling pathway']
ATP-binding cassette sub-family G member 5
225
ATP-binding cassette sub-family G member 8
109
9.2
65
0.17
Q9H222Q9H221['bile acid signaling pathway', 'cholesterol efflux', 'cholesterol homeostasis', 'intestinal cholesterol absorption', 'negative regulation of intestinal cholesterol absorption', 'negative regulation of intestinal phytosterol absorption', 'response to ionizing radiation', 'response to muscle activity', 'response to nutrient', 'response to xenobiotic stimulus', 'sterol transport', 'transmembrane transport', 'triglyceride homeostasis']['bile acid signaling pathway', 'cholesterol efflux', 'cholesterol homeostasis', 'intestinal cholesterol absorption', 'negative regulation of intestinal cholesterol absorption', 'negative regulation of intestinal phytosterol absorption', 'phospholipid transport', 'response to muscle activity', 'response to nutrient', 'response to xenobiotic stimulus', 'sterol transport', 'transmembrane transport', 'triglyceride homeostasis']
DNA (cytosine-5)-methyltransferase 3A
540
DNA (cytosine-5)-methyltransferase 3A
517
9.2
89
0.12
Q9Y6K1Q9Y6K1['aging', 'C-5 methylation of cytosine', 'cellular response to amino acid stimulus', 'cellular response to bisphenol A', 'cellular response to ethanol', 'cellular response to hypoxia', 'DNA methylation', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'DNA methylation on cytosine', 'DNA methylation-dependent heterochromatin assembly', 'hepatocyte apoptotic process', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron differentiation', 'positive regulation of cell death', 'regulation of gene expression by genomic imprinting', 'response to cocaine', 'response to estradiol', 'response to ionizing radiation', 'response to lead ion', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'spermatogenesis']['aging', 'C-5 methylation of cytosine', 'cellular response to amino acid stimulus', 'cellular response to bisphenol A', 'cellular response to ethanol', 'cellular response to hypoxia', 'DNA methylation', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'DNA methylation on cytosine', 'DNA methylation-dependent heterochromatin assembly', 'hepatocyte apoptotic process', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron differentiation', 'positive regulation of cell death', 'regulation of gene expression by genomic imprinting', 'response to cocaine', 'response to estradiol', 'response to ionizing radiation', 'response to lead ion', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'spermatogenesis']
GDP-mannose 4,6 dehydratase
142
GDP-mannose 4,6 dehydratase
142
9.2
63
0.17
O60547O60547["'de novo' GDP-L-fucose biosynthetic process", 'GDP-mannose metabolic process', 'Notch signaling pathway']["'de novo' GDP-L-fucose biosynthetic process", 'GDP-mannose metabolic process', 'Notch signaling pathway']
B-cell antigen receptor complex-associated protein beta chain
136
B-cell antigen receptor complex-associated protein beta chain
122
9.7
81
0.13
P40259P40259['adaptive immune response', 'B cell differentiation', 'B cell receptor signaling pathway', 'immune response', 'signal transduction']['adaptive immune response', 'B cell differentiation', 'B cell receptor signaling pathway', 'immune response', 'signal transduction']
Serine protease 1
48
Amyloid-beta precursor protein
300
9.2
99
0.11
P00760P05067['digestion', 'proteolysis']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Hemoglobin subunit zeta
105
Hemoglobin subunit beta
113
9.2
87
0.13
P02008P68871['carbon dioxide transport', 'cellular oxidant detoxification', 'hydrogen peroxide catabolic process', 'oxygen transport', 'positive regulation of cell death']['carbon dioxide transport', 'cellular oxidant detoxification', 'hydrogen peroxide catabolic process', 'nitric oxide transport', 'oxygen transport', 'platelet aggregation', 'positive regulation of cell death', 'positive regulation of nitric oxide biosynthetic process', 'regulation of blood pressure', 'renal absorption', 'response to hydrogen peroxide']
Histone-lysine N-methyltransferase 2C
1069
Histone-lysine N-methyltransferase 2C
1078
9.0
66
0.17
Q8NEZ4Q8NEZ4['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']
Glucocorticoid receptor
622
Glucocorticoid receptor
622
9.8
77
0.13
P04150P04150['adrenal gland development', 'apoptotic process', 'cell cycle', 'cell division', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin organization', 'chromosome segregation', 'glucocorticoid metabolic process', 'intracellular steroid hormone receptor signaling pathway', 'mammary gland duct morphogenesis', 'maternal behavior', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'signal transduction']['adrenal gland development', 'apoptotic process', 'cell cycle', 'cell division', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin organization', 'chromosome segregation', 'glucocorticoid metabolic process', 'intracellular steroid hormone receptor signaling pathway', 'mammary gland duct morphogenesis', 'maternal behavior', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'signal transduction']
Secreted frizzled-related protein 3
147
Secreted frizzled-related protein 3
147
8.9
87
0.13
P97401P97401['canonical Wnt signaling pathway', 'cochlea morphogenesis', 'convergent extension involved in organogenesis', 'epithelial cell development', 'hepatocyte differentiation', 'inner ear morphogenesis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cartilage development', 'negative regulation of cell development', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of hepatocyte differentiation', 'negative regulation of Wnt signaling pathway', 'neural crest cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of fat cell differentiation', 'somite development']['canonical Wnt signaling pathway', 'cochlea morphogenesis', 'convergent extension involved in organogenesis', 'epithelial cell development', 'hepatocyte differentiation', 'inner ear morphogenesis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cartilage development', 'negative regulation of cell development', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of hepatocyte differentiation', 'negative regulation of Wnt signaling pathway', 'neural crest cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of fat cell differentiation', 'somite development']
Hemoglobin subunit alpha
104
Hemoglobin subunit beta
112
8.9
89
0.13
P60523P60526[][]
Tubulin polyglutamylase TTLL6
179
Tubulin polyglutamylase TTLL6
259
8.9
66
0.17
A4Q9E8A4Q9E8['microtubule bundle formation', 'microtubule cytoskeleton organization', 'microtubule severing', 'positive regulation of cilium movement', 'protein polyglutamylation', 'regulation of cilium beat frequency involved in ciliary motility']['microtubule bundle formation', 'microtubule cytoskeleton organization', 'microtubule severing', 'positive regulation of cilium movement', 'protein polyglutamylation', 'regulation of cilium beat frequency involved in ciliary motility']
Histone-lysine N-methyltransferase 2C
1069
Histone-lysine N-methyltransferase 2C
1060
8.9
63
0.18
Q8NEZ4Q8NEZ4['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']
MORC family CW-type zinc finger protein 3
435
MORC family CW-type zinc finger protein 3
413
9.8
78
0.13
Q14149Q14149['innate immune response', 'maintenance of protein location in nucleus', 'negative regulation of fibroblast proliferation', 'peptidyl-serine phosphorylation', 'positive regulation of cellular senescence', 'post-embryonic development', 'protein phosphorylation', 'protein stabilization']['innate immune response', 'maintenance of protein location in nucleus', 'negative regulation of fibroblast proliferation', 'peptidyl-serine phosphorylation', 'positive regulation of cellular senescence', 'post-embryonic development', 'protein phosphorylation', 'protein stabilization']
Gremlin-1
178
Gremlin-1
141
8.9
76
0.15
O60565O60565['animal organ morphogenesis', 'apoptotic process', 'cardiac muscle cell differentiation', 'cardiac muscle cell myoblast differentiation', 'cell migration involved in sprouting angiogenesis', 'cell morphogenesis', 'cell-cell signaling', 'collagen fibril organization', 'determination of dorsal identity', 'embryonic limb morphogenesis', 'limb development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'negative regulation of apoptotic process', 'negative regulation of BMP signaling pathway', 'negative regulation of bone mineralization', 'negative regulation of bone mineralization involved in bone maturation', 'negative regulation of bone remodeling', 'negative regulation of bone trabecula formation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell growth', 'negative regulation of chondrocyte differentiation', 'negative regulation of monocyte chemotaxis', 'negative regulation of osteoblast differentiation', 'negative regulation of osteoblast proliferation', 'negative regulation of osteoclast proliferation', 'negative regulation of pathway-restricted SMAD protein phosphorylation', 'negative regulation of transcription, DNA-templated', 'positive regulation of angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell population proliferation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of receptor internalization', 'positive regulation of signaling receptor activity', 'positive regulation of telomerase activity', 'positive regulation of transcription by RNA polymerase II', 'proximal/distal pattern formation', 'regulation of epithelial to mesenchymal transition', 'regulation of focal adhesion assembly', 'sequestering of BMP from receptor via BMP binding', 'signal transduction', 'ureteric bud formation']['animal organ morphogenesis', 'apoptotic process', 'cardiac muscle cell differentiation', 'cardiac muscle cell myoblast differentiation', 'cell migration involved in sprouting angiogenesis', 'cell morphogenesis', 'cell-cell signaling', 'collagen fibril organization', 'determination of dorsal identity', 'embryonic limb morphogenesis', 'limb development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'negative regulation of apoptotic process', 'negative regulation of BMP signaling pathway', 'negative regulation of bone mineralization', 'negative regulation of bone mineralization involved in bone maturation', 'negative regulation of bone remodeling', 'negative regulation of bone trabecula formation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell growth', 'negative regulation of chondrocyte differentiation', 'negative regulation of monocyte chemotaxis', 'negative regulation of osteoblast differentiation', 'negative regulation of osteoblast proliferation', 'negative regulation of osteoclast proliferation', 'negative regulation of pathway-restricted SMAD protein phosphorylation', 'negative regulation of transcription, DNA-templated', 'positive regulation of angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell population proliferation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of receptor internalization', 'positive regulation of signaling receptor activity', 'positive regulation of telomerase activity', 'positive regulation of transcription by RNA polymerase II', 'proximal/distal pattern formation', 'regulation of epithelial to mesenchymal transition', 'regulation of focal adhesion assembly', 'sequestering of BMP from receptor via BMP binding', 'signal transduction', 'ureteric bud formation']
Prosaposin
241
Prosaposin
241
8.9
68
0.16
P07602P07602['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'epithelial cell differentiation involved in prostate gland development', 'ganglioside GM1 transport to membrane', 'lysosomal transport', 'positive regulation of beta-galactosidase activity', 'prostate gland growth', 'regulation of autophagy', 'regulation of lipid metabolic process', 'sphingolipid metabolic process']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'epithelial cell differentiation involved in prostate gland development', 'ganglioside GM1 transport to membrane', 'lysosomal transport', 'positive regulation of beta-galactosidase activity', 'prostate gland growth', 'regulation of autophagy', 'regulation of lipid metabolic process', 'sphingolipid metabolic process']
Histone deacetylase 8
275
Histone deacetylase 8
275
8.9
73
0.15
Q9BY41Q9BY41['chromatin organization', 'histone deacetylation', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'regulation of cohesin loading', 'regulation of protein stability', 'regulation of telomere maintenance', 'regulation of transcription by RNA polymerase II', 'sister chromatid cohesion']['chromatin organization', 'histone deacetylation', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'regulation of cohesin loading', 'regulation of protein stability', 'regulation of telomere maintenance', 'regulation of transcription by RNA polymerase II', 'sister chromatid cohesion']
Suppressor of cytokine signaling 2
167
Elongin-C
112
8.9
nan
nan
O14508P83940['cellular response to hormone stimulus', 'growth hormone receptor signaling pathway', 'intracellular signal transduction', 'lactation', 'mammary gland alveolus development', 'negative regulation of apoptotic process', 'negative regulation of multicellular organism growth', 'negative regulation of receptor signaling pathway via JAK-STAT', 'phosphatidylinositol phosphate biosynthetic process', 'positive regulation of neuron differentiation', 'protein ubiquitination', 'receptor signaling pathway via JAK-STAT', 'regulation of cell growth', 'regulation of signal transduction', 'response to estradiol']['positive regulation of transcription elongation from RNA polymerase II promoter', 'protein ubiquitination', 'transcription initiation from RNA polymerase II promoter', 'ubiquitin-dependent protein catabolic process']
Transforming growth factor beta-3 proprotein
377
Transforming growth factor beta-3 proprotein
409
8.9
84
0.13
P10600P10600['aging', 'BMP signaling pathway', 'cell-cell junction organization', 'detection of hypoxia', 'digestive tract development', 'embryonic neurocranium morphogenesis', 'face morphogenesis', 'female pregnancy', 'frontal suture morphogenesis', 'in utero embryonic development', 'inner ear development', 'lung alveolus development', 'mammary gland development', 'negative regulation of cell population proliferation', 'negative regulation of macrophage cytokine production', 'negative regulation of neuron apoptotic process', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of vascular associated smooth muscle cell proliferation', 'odontogenesis', 'ossification involved in bone remodeling', 'positive regulation of apoptotic process', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of filopodium assembly', 'positive regulation of MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stress fiber assembly', 'positive regulation of tight junction disassembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of cell population proliferation', 'response to estrogen', 'response to hypoxia', 'response to laminar fluid shear stress', 'response to progesterone', 'salivary gland morphogenesis', 'secondary palate development', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'wound healing']['aging', 'BMP signaling pathway', 'cell-cell junction organization', 'detection of hypoxia', 'digestive tract development', 'embryonic neurocranium morphogenesis', 'face morphogenesis', 'female pregnancy', 'frontal suture morphogenesis', 'in utero embryonic development', 'inner ear development', 'lung alveolus development', 'mammary gland development', 'negative regulation of cell population proliferation', 'negative regulation of macrophage cytokine production', 'negative regulation of neuron apoptotic process', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of vascular associated smooth muscle cell proliferation', 'odontogenesis', 'ossification involved in bone remodeling', 'positive regulation of apoptotic process', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of filopodium assembly', 'positive regulation of MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stress fiber assembly', 'positive regulation of tight junction disassembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of cell population proliferation', 'response to estrogen', 'response to hypoxia', 'response to laminar fluid shear stress', 'response to progesterone', 'salivary gland morphogenesis', 'secondary palate development', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'wound healing']
Protein disulfide-isomerase
400
Microsomal triglyceride transfer protein large subunit
866
8.9
69
0.16
P07237P55157['cellular response to hypoxia', 'cellular response to interleukin-7', 'interleukin-12-mediated signaling pathway', 'interleukin-23-mediated signaling pathway', 'peptidyl-proline hydroxylation to 4-hydroxy-L-proline', 'positive regulation of cell adhesion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of viral entry into host cell', 'protein folding', 'protein folding in endoplasmic reticulum', 'regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'response to endoplasmic reticulum stress']['cholesterol homeostasis', 'chylomicron assembly', 'circadian rhythm', 'establishment of localization in cell', 'lipid metabolic process', 'lipoprotein metabolic process', 'lipoprotein transport', 'low-density lipoprotein particle remodeling', 'phospholipid transport', 'plasma lipoprotein particle assembly', 'protein lipidation', 'protein secretion', 'response to calcium ion', 'triglyceride metabolic process', 'triglyceride transport', 'very-low-density lipoprotein particle assembly']
C-C motif chemokine 5
33
C-C motif chemokine 5
57
8.9
67
0.17
P13501P13501['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'chemokine-mediated signaling pathway', 'chemotaxis', 'dendritic cell chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of innate immune response', 'positive regulation of macrophage chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of translational initiation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of viral genome replication', 'protein kinase B signaling', 'regulation of chronic inflammatory response', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to toxic substance', 'response to virus']['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'chemokine-mediated signaling pathway', 'chemotaxis', 'dendritic cell chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of innate immune response', 'positive regulation of macrophage chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of translational initiation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of viral genome replication', 'protein kinase B signaling', 'regulation of chronic inflammatory response', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to toxic substance', 'response to virus']
Neurotrophin-3
248
Neurotrophin-3
205
9.0
88
0.13
P20783P20783['activation of GTPase activity', 'activation of protein kinase B activity', 'cell-cell signaling', 'induction of positive chemotaxis', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of peptidyl-tyrosine phosphorylation', 'nerve development', 'nerve growth factor signaling pathway', 'nervous system development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of MAP kinase activity', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of receptor internalization', 'regulation of apoptotic process', 'regulation of neuron differentiation', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of GTPase activity', 'activation of protein kinase B activity', 'cell-cell signaling', 'induction of positive chemotaxis', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of peptidyl-tyrosine phosphorylation', 'nerve development', 'nerve growth factor signaling pathway', 'nervous system development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of MAP kinase activity', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of receptor internalization', 'regulation of apoptotic process', 'regulation of neuron differentiation', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Copper transport protein ATOX1
15
Copper-transporting ATPase 1
19
9.1
61
0.18
O00244Q04656['cellular copper ion homeostasis', 'copper ion transport', 'response to oxidative stress']['blood vessel development', 'blood vessel remodeling', 'cartilage development', 'catecholamine metabolic process', 'cellular copper ion homeostasis', 'cellular response to amino acid stimulus', 'cellular response to antibiotic', 'cellular response to cadmium ion', 'cellular response to cobalt ion', 'cellular response to copper ion', 'cellular response to hypoxia', 'cellular response to iron ion', 'cellular response to lead ion', 'cellular response to platelet-derived growth factor stimulus', 'central nervous system neuron development', 'cerebellar Purkinje cell differentiation', 'collagen fibril organization', 'copper ion export', 'copper ion homeostasis', 'copper ion import', 'copper ion transport', 'detoxification of copper ion', 'dopamine metabolic process', 'elastic fiber assembly', 'elastin biosynthetic process', 'epinephrine metabolic process', 'extracellular matrix organization', 'female pregnancy', 'hair follicle morphogenesis', 'in utero embryonic development', 'lactation', 'liver development', 'locomotory behavior', 'lung alveolus development', 'mitochondrion organization', 'negative regulation of iron ion transmembrane transport', 'neuron projection morphogenesis', 'norepinephrine metabolic process', 'peptidyl-lysine modification', 'pigmentation', 'positive regulation of catalytic activity', 'positive regulation of cell size', 'positive regulation of epithelial cell proliferation', 'positive regulation of lamellipodium assembly', 'positive regulation of melanin biosynthetic process', 'positive regulation of response to wounding', 'positive regulation of tyrosinase activity', 'positive regulation of vascular associated smooth muscle cell migration', 'pyramidal neuron development', 'regulation of cytochrome-c oxidase activity', 'regulation of gene expression', 'regulation of oxidative phosphorylation', 'removal of superoxide radicals', 'response to iron(III) ion', 'response to manganese ion', 'response to zinc ion', 'serotonin metabolic process', 'skin development', 'T-helper cell differentiation', 'tryptophan metabolic process']
Acyl-protein thioesterase 1
173
Acyl-protein thioesterase 1
211
9.1
68
0.16
O75608O75608['fatty acid metabolic process', 'negative regulation of Golgi to plasma membrane protein transport', 'protein depalmitoylation']['fatty acid metabolic process', 'negative regulation of Golgi to plasma membrane protein transport', 'protein depalmitoylation']
Neurotrophin-4
201
Neurotrophin-4
158
9.0
91
0.12
P34130P34130['adult locomotory behavior', 'epidermis development', 'ganglion mother cell fate determination', 'innervation', 'long-term memory', 'mechanoreceptor differentiation', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of peptidyl-serine phosphorylation', 'regulation of neuron differentiation', 'sensory organ boundary specification', 'taste bud development', 'transmembrane receptor protein tyrosine kinase signaling pathway']['adult locomotory behavior', 'epidermis development', 'ganglion mother cell fate determination', 'innervation', 'long-term memory', 'mechanoreceptor differentiation', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of peptidyl-serine phosphorylation', 'regulation of neuron differentiation', 'sensory organ boundary specification', 'taste bud development', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Glutathione S-transferase Mu 4
87
Glutathione S-transferase Mu 4
78
9.0
71
0.16
Q03013Q03013['glutathione metabolic process', 'long-chain fatty acid biosynthetic process', 'nitrobenzene metabolic process', 'xenobiotic catabolic process']['glutathione metabolic process', 'long-chain fatty acid biosynthetic process', 'nitrobenzene metabolic process', 'xenobiotic catabolic process']
Amyloid-beta precursor protein
105
Amyloid-beta precursor protein
98
9.0
69
0.16
P05067P05067['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Fibrinogen gamma chain
35
Fibrinogen gamma chain
45
9.0
70
0.16
P02679P02679['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
368
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
368
9.8
73
0.14
I3LG77I3LG77['dATP catabolic process', 'defense response to virus', 'dGTP catabolic process', 'DNA strand resection involved in replication fork processing', 'double-strand break repair via homologous recombination', 'negative regulation of type I interferon-mediated signaling pathway', 'protein homotetramerization', 'regulation of innate immune response', 'somatic hypermutation of immunoglobulin genes']['dATP catabolic process', 'defense response to virus', 'dGTP catabolic process', 'DNA strand resection involved in replication fork processing', 'double-strand break repair via homologous recombination', 'negative regulation of type I interferon-mediated signaling pathway', 'protein homotetramerization', 'regulation of innate immune response', 'somatic hypermutation of immunoglobulin genes']
C-C motif chemokine 16
60
C-C motif chemokine 16
60
9.0
54
0.21
O15467O15467['cell communication', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']['cell communication', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']
Inhibitor of nuclear factor kappa-B kinase subunit beta
716
Inhibitor of nuclear factor kappa-B kinase subunit beta
716
9.0
69
0.16
O14920O14920['antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent', 'cellular response to tumor necrosis factor', 'cortical actin cytoskeleton organization', 'Fc-epsilon receptor signaling pathway', 'I-kappaB kinase/NF-kappaB signaling', 'inflammatory response', 'innate immune response', 'interleukin-1-mediated signaling pathway', 'negative regulation of bicellular tight junction assembly', 'negative regulation of myosin-light-chain-phosphatase activity', 'peptidyl-serine phosphorylation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein localization to plasma membrane', 'protein phosphorylation', 'regulation of establishment of endothelial barrier', 'regulation of phosphorylation', 'regulation of tumor necrosis factor-mediated signaling pathway', 'response to virus', 'stimulatory C-type lectin receptor signaling pathway', 'stress-activated MAPK cascade', 'T cell receptor signaling pathway', 'tumor necrosis factor-mediated signaling pathway']['antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent', 'cellular response to tumor necrosis factor', 'cortical actin cytoskeleton organization', 'Fc-epsilon receptor signaling pathway', 'I-kappaB kinase/NF-kappaB signaling', 'inflammatory response', 'innate immune response', 'interleukin-1-mediated signaling pathway', 'negative regulation of bicellular tight junction assembly', 'negative regulation of myosin-light-chain-phosphatase activity', 'peptidyl-serine phosphorylation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein localization to plasma membrane', 'protein phosphorylation', 'regulation of establishment of endothelial barrier', 'regulation of phosphorylation', 'regulation of tumor necrosis factor-mediated signaling pathway', 'response to virus', 'stimulatory C-type lectin receptor signaling pathway', 'stress-activated MAPK cascade', 'T cell receptor signaling pathway', 'tumor necrosis factor-mediated signaling pathway']
S-adenosylmethionine synthase isoform type-1
68
S-adenosylmethionine synthase isoform type-1
34
9.0
86
0.13
Q00266Q00266['methionine catabolic process', 'one-carbon metabolic process', 'protein homotetramerization', 'S-adenosylmethionine biosynthetic process']['methionine catabolic process', 'one-carbon metabolic process', 'protein homotetramerization', 'S-adenosylmethionine biosynthetic process']
Kallikrein-7
239
Kallikrein-7
239
9.0
78
0.14
P49862P49862['epidermis development', 'extracellular matrix disassembly', 'positive regulation of antibacterial peptide production', 'proteolysis']['epidermis development', 'extracellular matrix disassembly', 'positive regulation of antibacterial peptide production', 'proteolysis']
E3 ubiquitin-protein ligase TRIM7
378
E3 ubiquitin-protein ligase TRIM7
455
9.0
71
0.16
Q9C029Q9C029['protein ubiquitination']['protein ubiquitination']
Protein phosphatase 1A
72
Protein phosphatase 1A
72
9.0
70
0.16
P35813P35813['cellular response to transforming growth factor beta stimulus', 'dephosphorylation', 'N-terminal protein myristoylation', 'negative regulation of BMP signaling pathway', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of NIK/NF-kappaB signaling', 'negative regulation of SMAD protein complex assembly', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'peptidyl-threonine dephosphorylation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of protein export from nucleus', 'positive regulation of transcription, DNA-templated', 'protein dephosphorylation', 'protein export from nucleus', 'regulation of cell cycle']['cellular response to transforming growth factor beta stimulus', 'dephosphorylation', 'N-terminal protein myristoylation', 'negative regulation of BMP signaling pathway', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of NIK/NF-kappaB signaling', 'negative regulation of SMAD protein complex assembly', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'peptidyl-threonine dephosphorylation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of protein export from nucleus', 'positive regulation of transcription, DNA-templated', 'protein dephosphorylation', 'protein export from nucleus', 'regulation of cell cycle']
Protein S100-A3
23
Protein S100-A3
86
9.0
79
0.14
P33764P33764[][]
Insulin
31
Insulin
31
9.8
49
0.21
P01308P01308['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']
Poly(A) RNA polymerase, mitochondrial
291
Poly(A) RNA polymerase, mitochondrial
291
9.8
76
0.13
Q9NVV4Q9NVV4['histone mRNA catabolic process', 'mRNA polyadenylation', "RNA 3'-end processing"]['histone mRNA catabolic process', 'mRNA polyadenylation', "RNA 3'-end processing"]
Kinesin-like protein KIF2C
245
Kinesin-like protein KIF2C
287
9.0
63
0.18
Q99661Q99661['attachment of mitotic spindle microtubules to kinetochore', 'cell division', 'establishment or maintenance of microtubule cytoskeleton polarity', 'metaphase plate congression', 'microtubule depolymerization', 'microtubule-based movement', 'mitotic metaphase plate congression', 'regulation of chromosome segregation']['attachment of mitotic spindle microtubules to kinetochore', 'cell division', 'establishment or maintenance of microtubule cytoskeleton polarity', 'metaphase plate congression', 'microtubule depolymerization', 'microtubule-based movement', 'mitotic metaphase plate congression', 'regulation of chromosome segregation']
GTP-binding protein RAD
221
GTP-binding protein RAD
221
9.0
86
0.13
P55042P55042['negative regulation of high voltage-gated calcium channel activity', 'small GTPase mediated signal transduction']['negative regulation of high voltage-gated calcium channel activity', 'small GTPase mediated signal transduction']
Urokinase plasminogen activator surface receptor
98
Urokinase plasminogen activator surface receptor
39
9.0
51
0.22
Q03405Q03405['blood coagulation', 'chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'negative regulation of intrinsic apoptotic signaling pathway', 'positive regulation of DNA binding', 'positive regulation of epidermal growth factor receptor signaling pathway', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of protein phosphorylation', 'positive regulation of release of cytochrome c from mitochondria', 'regulation of cell adhesion', 'regulation of fibrinolysis', 'regulation of plasminogen activation', 'regulation of proteolysis', 'signal transduction', 'urokinase plasminogen activator signaling pathway']['blood coagulation', 'chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'negative regulation of intrinsic apoptotic signaling pathway', 'positive regulation of DNA binding', 'positive regulation of epidermal growth factor receptor signaling pathway', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of protein phosphorylation', 'positive regulation of release of cytochrome c from mitochondria', 'regulation of cell adhesion', 'regulation of fibrinolysis', 'regulation of plasminogen activation', 'regulation of proteolysis', 'signal transduction', 'urokinase plasminogen activator signaling pathway']
DNA repair protein XRCC1
12
DNA repair protein XRCC1
12
9.0
85
0.13
P18887P18887['base-excision repair', 'cerebellum morphogenesis', 'double-strand break repair via nonhomologous end joining', 'hippocampus development', 'negative regulation of protection from non-homologous end joining at telomere', 'negative regulation of protein ADP-ribosylation', 'positive regulation of DNA ligase activity', 'positive regulation of single strand break repair', 'replication-born double-strand break repair via sister chromatid exchange', 'response to hydroperoxide', 'response to hypoxia', 'response to organic substance', 'response to xenobiotic stimulus', 'single strand break repair', 'telomeric DNA-containing double minutes formation', 'voluntary musculoskeletal movement']['base-excision repair', 'cerebellum morphogenesis', 'double-strand break repair via nonhomologous end joining', 'hippocampus development', 'negative regulation of protection from non-homologous end joining at telomere', 'negative regulation of protein ADP-ribosylation', 'positive regulation of DNA ligase activity', 'positive regulation of single strand break repair', 'replication-born double-strand break repair via sister chromatid exchange', 'response to hydroperoxide', 'response to hypoxia', 'response to organic substance', 'response to xenobiotic stimulus', 'single strand break repair', 'telomeric DNA-containing double minutes formation', 'voluntary musculoskeletal movement']
Growth/differentiation factor 11
371
Growth/differentiation factor 11
341
9.0
89
0.13
O95390O95390['amacrine cell differentiation', 'camera-type eye morphogenesis', 'cell population proliferation', 'mesoderm development', 'metanephros development', 'negative regulation of amacrine cell differentiation', 'negative regulation of cell population proliferation', 'nervous system development', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'roof of mouth development', 'skeletal system development', 'SMAD protein signal transduction', 'spinal cord anterior/posterior patterning', 'type B pancreatic cell maturation', 'ureteric bud development']['amacrine cell differentiation', 'camera-type eye morphogenesis', 'cell population proliferation', 'mesoderm development', 'metanephros development', 'negative regulation of amacrine cell differentiation', 'negative regulation of cell population proliferation', 'nervous system development', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'roof of mouth development', 'skeletal system development', 'SMAD protein signal transduction', 'spinal cord anterior/posterior patterning', 'type B pancreatic cell maturation', 'ureteric bud development']
Interleukin-17F
154
Interleukin-17F
107
8.9
85
0.13
Q96PD4Q96PD4['adaptive immune response', 'cartilage development', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'inflammatory response', 'innate immune response', 'interleukin-17-mediated signaling pathway', 'negative regulation of angiogenesis', 'positive regulation of antimicrobial peptide production', 'positive regulation of chemokine (C-X-C motif) ligand 1 production', 'positive regulation of cytokine production', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of interleukin-6 production', 'positive regulation of lymphotoxin A production', 'positive regulation of transcription by RNA polymerase II', 'regulation of granulocyte macrophage colony-stimulating factor production', 'regulation of interleukin-2 production', 'regulation of interleukin-6 production', 'regulation of interleukin-8 production', 'regulation of transforming growth factor beta receptor signaling pathway']['adaptive immune response', 'cartilage development', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'inflammatory response', 'innate immune response', 'interleukin-17-mediated signaling pathway', 'negative regulation of angiogenesis', 'positive regulation of antimicrobial peptide production', 'positive regulation of chemokine (C-X-C motif) ligand 1 production', 'positive regulation of cytokine production', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of interleukin-6 production', 'positive regulation of lymphotoxin A production', 'positive regulation of transcription by RNA polymerase II', 'regulation of granulocyte macrophage colony-stimulating factor production', 'regulation of interleukin-2 production', 'regulation of interleukin-6 production', 'regulation of interleukin-8 production', 'regulation of transforming growth factor beta receptor signaling pathway']
Choline-phosphate cytidylyltransferase A
139
Choline-phosphate cytidylyltransferase A
139
8.9
106
0.11
P19836P19836['CDP-choline pathway', 'phosphatidylcholine biosynthetic process']['CDP-choline pathway', 'phosphatidylcholine biosynthetic process']
Mitogen-activated protein kinase kinase kinase 20
22
Mitogen-activated protein kinase kinase kinase 20
285
9.8
69
0.15
Q9NYL2Q9NYL2['cell cycle', 'cell death', 'cell differentiation', 'cellular response to gamma radiation', 'cytoskeleton organization', 'DNA damage checkpoint signaling', 'embryonic digit morphogenesis', 'JNK cascade', 'limb development', 'p38MAPK cascade', 'peptidyl-serine phosphorylation', 'positive regulation of apoptotic process', 'positive regulation of mitotic DNA damage checkpoint', 'protein phosphorylation', 'stress-activated MAPK cascade']['cell cycle', 'cell death', 'cell differentiation', 'cellular response to gamma radiation', 'cytoskeleton organization', 'DNA damage checkpoint signaling', 'embryonic digit morphogenesis', 'JNK cascade', 'limb development', 'p38MAPK cascade', 'peptidyl-serine phosphorylation', 'positive regulation of apoptotic process', 'positive regulation of mitotic DNA damage checkpoint', 'protein phosphorylation', 'stress-activated MAPK cascade']
Fibrinogen beta chain
106
Fibrinogen beta chain
106
8.9
81
0.14
P02675P02675['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']
Histone-lysine N-methyltransferase 2C
1081
Histone-lysine N-methyltransferase 2C
1069
9.0
68
0.16
Q8NEZ4Q8NEZ4['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']
Adenylate cyclase type 2
911
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
237
8.9
83
0.13
P26769P04896['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cAMP biosynthetic process', 'cAMP-mediated signaling', 'cellular response to forskolin']['adenylate cyclase-activating adrenergic receptor signaling pathway', 'adenylate cyclase-activating dopamine receptor signaling pathway', 'adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'bone development', 'cognition', 'developmental growth', 'hair follicle placode formation', 'platelet aggregation', 'positive regulation of cAMP-mediated signaling', 'positive regulation of GTPase activity', 'sensory perception of chemical stimulus']
Uridine phosphorylase
21
Uridine phosphorylase
224
9.8
56
0.18
A5PJH9A5PJH9['nucleoside catabolic process', 'nucleotide catabolic process', 'UMP salvage']['nucleoside catabolic process', 'nucleotide catabolic process', 'UMP salvage']
cGMP-dependent 3',5'-cyclic phosphodiesterase
391
cGMP-dependent 3',5'-cyclic phosphodiesterase
393
8.9
53
0.21
O00408O00408['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'aorta development', 'cAMP-mediated signaling', 'cellular response to 2,3,7,8-tetrachlorodibenzodioxine', 'cellular response to cAMP', 'cellular response to cGMP', 'cellular response to granulocyte macrophage colony-stimulating factor stimulus', 'cellular response to macrophage colony-stimulating factor stimulus', 'cellular response to mechanical stimulus', 'cellular response to transforming growth factor beta stimulus', 'cellular response to xenobiotic stimulus', 'cGMP catabolic process', 'cGMP-mediated signaling', 'establishment of endothelial barrier', 'heart valve development', 'monocyte differentiation', 'negative regulation of cAMP-mediated signaling', 'negative regulation of cGMP-mediated signaling', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of vascular permeability', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of vascular permeability', 'regulation of cAMP-mediated signaling', 'regulation of cGMP-mediated signaling', 'regulation of mitochondrion organization', 'signal transduction', 'ventricular septum development']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'aorta development', 'cAMP-mediated signaling', 'cellular response to 2,3,7,8-tetrachlorodibenzodioxine', 'cellular response to cAMP', 'cellular response to cGMP', 'cellular response to granulocyte macrophage colony-stimulating factor stimulus', 'cellular response to macrophage colony-stimulating factor stimulus', 'cellular response to mechanical stimulus', 'cellular response to transforming growth factor beta stimulus', 'cellular response to xenobiotic stimulus', 'cGMP catabolic process', 'cGMP-mediated signaling', 'establishment of endothelial barrier', 'heart valve development', 'monocyte differentiation', 'negative regulation of cAMP-mediated signaling', 'negative regulation of cGMP-mediated signaling', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of vascular permeability', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of vascular permeability', 'regulation of cAMP-mediated signaling', 'regulation of cGMP-mediated signaling', 'regulation of mitochondrion organization', 'signal transduction', 'ventricular septum development']
Tumor necrosis factor ligand superfamily member 13
202
Tumor necrosis factor ligand superfamily member 13
202
9.8
99
0.1
Q9D777Q9D777['germinal center formation', 'immunoglobulin mediated immune response', 'positive regulation of cell population proliferation', 'positive regulation of germinal center formation', 'positive regulation of isotype switching to IgA isotypes', 'regulation of immune response']['germinal center formation', 'immunoglobulin mediated immune response', 'positive regulation of cell population proliferation', 'positive regulation of germinal center formation', 'positive regulation of isotype switching to IgA isotypes', 'regulation of immune response']
DNA repair protein RAD50
684
DNA repair protein RAD50
680
9.7
61
0.17
Q92878Q92878['cellular response to DNA damage stimulus', 'chromosome organization involved in meiotic cell cycle', 'DNA double-strand break processing', 'DNA duplex unwinding', 'DNA recombination', 'DNA repair', 'DNA strand resection involved in replication fork processing', 'double-strand break repair', 'homologous recombination', 'mitotic G2/M transition checkpoint', 'negative regulation of telomere capping', 'nucleic acid phosphodiester bond hydrolysis', 'positive regulation of kinase activity', 'positive regulation of protein autophosphorylation', 'positive regulation of telomere maintenance', 'reciprocal meiotic recombination', 'regulation of mitotic recombination', 'telomere maintenance', 'telomere maintenance via recombination', 'telomere maintenance via telomerase', "telomeric 3' overhang formation"]['cellular response to DNA damage stimulus', 'chromosome organization involved in meiotic cell cycle', 'DNA double-strand break processing', 'DNA duplex unwinding', 'DNA recombination', 'DNA repair', 'DNA strand resection involved in replication fork processing', 'double-strand break repair', 'homologous recombination', 'mitotic G2/M transition checkpoint', 'negative regulation of telomere capping', 'nucleic acid phosphodiester bond hydrolysis', 'positive regulation of kinase activity', 'positive regulation of protein autophosphorylation', 'positive regulation of telomere maintenance', 'reciprocal meiotic recombination', 'regulation of mitotic recombination', 'telomere maintenance', 'telomere maintenance via recombination', 'telomere maintenance via telomerase', "telomeric 3' overhang formation"]
3-ketoacyl-CoA thiolase, peroxisomal
87
3-ketoacyl-CoA thiolase, peroxisomal
87
9.8
106
0.1
P09110P09110['alpha-linolenic acid metabolic process', 'bile acid metabolic process', 'fatty acid beta-oxidation', 'fatty acid beta-oxidation using acyl-CoA oxidase', 'phenylacetate catabolic process', 'very long-chain fatty acid metabolic process']['alpha-linolenic acid metabolic process', 'bile acid metabolic process', 'fatty acid beta-oxidation', 'fatty acid beta-oxidation using acyl-CoA oxidase', 'phenylacetate catabolic process', 'very long-chain fatty acid metabolic process']
Ubiquitin carboxyl-terminal hydrolase 11
214
Ubiquitin carboxyl-terminal hydrolase 11
214
9.2
47
0.23
Q5D006Q5D006['protein deubiquitination', 'ubiquitin-dependent protein catabolic process']['protein deubiquitination', 'ubiquitin-dependent protein catabolic process']
Estrogen receptor
221
Estrogen receptor
237
9.8
67
0.15
P03372P03372['androgen metabolic process', 'antral ovarian follicle growth', 'cellular response to estradiol stimulus', 'cellular response to estrogen stimulus', 'chromatin remodeling', 'epithelial cell development', 'epithelial cell proliferation involved in mammary gland duct elongation', 'fibroblast proliferation', 'intracellular estrogen receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'male gonad development', 'mammary gland alveolus development', 'mammary gland branching involved in pregnancy', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of gene expression', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of miRNA maturation', 'negative regulation of transcription by RNA polymerase II', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of fibroblast proliferation', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of phospholipase C activity', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis', 'prostate epithelial cord elongation', 'protein localization to chromatin', 'regulation of branching involved in prostate gland morphogenesis', 'regulation of epithelial cell apoptotic process', 'regulation of inflammatory response', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to estradiol', 'response to estrogen', 'signal transduction', 'stem cell differentiation', 'transcription by RNA polymerase II', 'uterus development', 'vagina development']['androgen metabolic process', 'antral ovarian follicle growth', 'cellular response to estradiol stimulus', 'cellular response to estrogen stimulus', 'chromatin remodeling', 'epithelial cell development', 'epithelial cell proliferation involved in mammary gland duct elongation', 'fibroblast proliferation', 'intracellular estrogen receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'male gonad development', 'mammary gland alveolus development', 'mammary gland branching involved in pregnancy', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of gene expression', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of miRNA maturation', 'negative regulation of transcription by RNA polymerase II', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of fibroblast proliferation', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of phospholipase C activity', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis', 'prostate epithelial cord elongation', 'protein localization to chromatin', 'regulation of branching involved in prostate gland morphogenesis', 'regulation of epithelial cell apoptotic process', 'regulation of inflammatory response', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to estradiol', 'response to estrogen', 'signal transduction', 'stem cell differentiation', 'transcription by RNA polymerase II', 'uterus development', 'vagina development']
Alpha-actinin-2
270
Alpha-actinin-2
862
9.8
62
0.17
P35609P35609['actin cytoskeleton organization', 'actin filament uncapping', 'cardiac muscle cell development', 'cell adhesion', 'focal adhesion assembly', 'microspike assembly', 'muscle cell development', 'negative regulation of potassium ion transmembrane transporter activity', 'negative regulation of potassium ion transport', 'negative regulation of protein localization to cell surface', 'phospholipase C-activating angiotensin-activated signaling pathway', 'positive regulation of cation channel activity', 'positive regulation of endocytic recycling', 'positive regulation of potassium ion transmembrane transporter activity', 'positive regulation of potassium ion transport', 'protein localization to plasma membrane', 'regulation of apoptotic process', 'regulation of membrane potential', 'sarcomere organization']['actin cytoskeleton organization', 'actin filament uncapping', 'cardiac muscle cell development', 'cell adhesion', 'focal adhesion assembly', 'microspike assembly', 'muscle cell development', 'negative regulation of potassium ion transmembrane transporter activity', 'negative regulation of potassium ion transport', 'negative regulation of protein localization to cell surface', 'phospholipase C-activating angiotensin-activated signaling pathway', 'positive regulation of cation channel activity', 'positive regulation of endocytic recycling', 'positive regulation of potassium ion transmembrane transporter activity', 'positive regulation of potassium ion transport', 'protein localization to plasma membrane', 'regulation of apoptotic process', 'regulation of membrane potential', 'sarcomere organization']
Collagen alpha-1(II) chain
69
Collagen alpha-1(II) chain
69
9.8
55
0.19
P02458P02458['anterior head development', 'cartilage condensation', 'cartilage development', 'cartilage development involved in endochondral bone morphogenesis', 'cellular response to BMP stimulus', 'central nervous system development', 'chondrocyte differentiation', 'collagen fibril organization', 'embryonic skeletal joint morphogenesis', 'endochondral ossification', 'extracellular matrix organization', 'extrinsic apoptotic signaling pathway in absence of ligand', 'heart morphogenesis', 'inner ear morphogenesis', 'limb bud formation', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'notochord development', 'otic vesicle development', 'proteoglycan metabolic process', 'regulation of gene expression', 'roof of mouth development', 'sensory perception of sound', 'skeletal system development', 'tissue homeostasis', 'visual perception']['anterior head development', 'cartilage condensation', 'cartilage development', 'cartilage development involved in endochondral bone morphogenesis', 'cellular response to BMP stimulus', 'central nervous system development', 'chondrocyte differentiation', 'collagen fibril organization', 'embryonic skeletal joint morphogenesis', 'endochondral ossification', 'extracellular matrix organization', 'extrinsic apoptotic signaling pathway in absence of ligand', 'heart morphogenesis', 'inner ear morphogenesis', 'limb bud formation', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'notochord development', 'otic vesicle development', 'proteoglycan metabolic process', 'regulation of gene expression', 'roof of mouth development', 'sensory perception of sound', 'skeletal system development', 'tissue homeostasis', 'visual perception']
Trypsin
33
Tissue factor pathway inhibitor
134
9.1
97
0.11
P00761P10646['digestion', 'proteolysis']['blood coagulation', 'cellular response to steroid hormone stimulus', 'negative regulation of blood coagulation']
Endothelin-1
67
Endothelin-1
63
9.8
48
0.21
P05305P05305['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'artery smooth muscle contraction', 'axon extension', 'axonogenesis involved in innervation', 'body fluid secretion', 'branching involved in blood vessel morphogenesis', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cardiac neural crest cell migration involved in outflow tract morphogenesis', 'cartilage development', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to calcium ion', 'cellular response to fatty acid', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to human chorionic gonadotropin stimulus', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to luteinizing hormone stimulus', 'cellular response to mineralocorticoid stimulus', 'cellular response to organic substance', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to xenobiotic stimulus', 'dorsal/ventral pattern formation', 'embryonic heart tube development', 'endothelin receptor signaling pathway', 'endothelin receptor signaling pathway involved in heart process', 'epithelial fluid transport', 'ERK1 and ERK2 cascade', 'G protein-coupled receptor signaling pathway', 'histamine secretion', 'I-kappaB kinase/NF-kappaB signaling', 'in utero embryonic development', 'inositol phosphate-mediated signaling', 'leukocyte activation', 'maternal process involved in parturition', 'meiotic cell cycle process involved in oocyte maturation', 'membrane depolarization', 'middle ear morphogenesis', 'mitochondrion organization', 'multicellular organism aging', 'negative regulation of blood coagulation', 'negative regulation of gene expression', 'negative regulation of hormone secretion', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein metabolic process', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'neural crest cell fate commitment', 'nitric oxide transport', 'noradrenergic neuron differentiation', 'peptide hormone secretion', 'pharyngeal arch artery morphogenesis', 'phosphatidylinositol 3-kinase signaling', 'phospholipase D-activating G protein-coupled receptor signaling pathway', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cation channel activity', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell size', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell migration', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of JUN kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of odontogenesis', 'positive regulation of prostaglandin secretion', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'positive regulation of renal sodium excretion', 'positive regulation of sarcomere organization', 'positive regulation of signaling receptor activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'prostaglandin biosynthetic process', 'protein kinase A signaling', 'protein kinase C deactivation', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'regulation of glucose transmembrane transport', 'regulation of pH', 'regulation of sensory perception of pain', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'renal sodium ion absorption', 'respiratory gaseous exchange by respiratory system', 'response to activity', 'response to amino acid', 'response to amphetamine', 'response to dexamethasone', 'response to leptin', 'response to lipopolysaccharide', 'response to muscle stretch', 'response to nicotine', 'response to ozone', 'response to prostaglandin F', 'response to salt', 'response to testosterone', 'rhythmic excitation', 'semaphorin-plexin signaling pathway involved in axon guidance', 'sensory perception of pain', 'superoxide anion generation', 'sympathetic neuron axon guidance', 'thyroid gland development', 'transcription by RNA polymerase II', 'vasoconstriction', 'vein smooth muscle contraction']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'artery smooth muscle contraction', 'axon extension', 'axonogenesis involved in innervation', 'body fluid secretion', 'branching involved in blood vessel morphogenesis', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cardiac neural crest cell migration involved in outflow tract morphogenesis', 'cartilage development', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to calcium ion', 'cellular response to fatty acid', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to human chorionic gonadotropin stimulus', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to luteinizing hormone stimulus', 'cellular response to mineralocorticoid stimulus', 'cellular response to organic substance', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to xenobiotic stimulus', 'dorsal/ventral pattern formation', 'embryonic heart tube development', 'endothelin receptor signaling pathway', 'endothelin receptor signaling pathway involved in heart process', 'epithelial fluid transport', 'ERK1 and ERK2 cascade', 'G protein-coupled receptor signaling pathway', 'histamine secretion', 'I-kappaB kinase/NF-kappaB signaling', 'in utero embryonic development', 'inositol phosphate-mediated signaling', 'leukocyte activation', 'maternal process involved in parturition', 'meiotic cell cycle process involved in oocyte maturation', 'membrane depolarization', 'middle ear morphogenesis', 'mitochondrion organization', 'multicellular organism aging', 'negative regulation of blood coagulation', 'negative regulation of gene expression', 'negative regulation of hormone secretion', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein metabolic process', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'neural crest cell fate commitment', 'nitric oxide transport', 'noradrenergic neuron differentiation', 'peptide hormone secretion', 'pharyngeal arch artery morphogenesis', 'phosphatidylinositol 3-kinase signaling', 'phospholipase D-activating G protein-coupled receptor signaling pathway', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cation channel activity', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell size', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell migration', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of JUN kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of odontogenesis', 'positive regulation of prostaglandin secretion', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'positive regulation of renal sodium excretion', 'positive regulation of sarcomere organization', 'positive regulation of signaling receptor activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'prostaglandin biosynthetic process', 'protein kinase A signaling', 'protein kinase C deactivation', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'regulation of glucose transmembrane transport', 'regulation of pH', 'regulation of sensory perception of pain', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'renal sodium ion absorption', 'respiratory gaseous exchange by respiratory system', 'response to activity', 'response to amino acid', 'response to amphetamine', 'response to dexamethasone', 'response to leptin', 'response to lipopolysaccharide', 'response to muscle stretch', 'response to nicotine', 'response to ozone', 'response to prostaglandin F', 'response to salt', 'response to testosterone', 'rhythmic excitation', 'semaphorin-plexin signaling pathway involved in axon guidance', 'sensory perception of pain', 'superoxide anion generation', 'sympathetic neuron axon guidance', 'thyroid gland development', 'transcription by RNA polymerase II', 'vasoconstriction', 'vein smooth muscle contraction']
Insulin
96
Insulin
96
9.1
51
0.22
P01308P01308['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']
Glycine--tRNA ligase
155
Glycine--tRNA ligase
180
9.1
78
0.14
P41250P41250['diadenosine tetraphosphate biosynthetic process', 'glycyl-tRNA aminoacylation', 'mitochondrial glycyl-tRNA aminoacylation', 'tRNA aminoacylation for protein translation']['diadenosine tetraphosphate biosynthetic process', 'glycyl-tRNA aminoacylation', 'mitochondrial glycyl-tRNA aminoacylation', 'tRNA aminoacylation for protein translation']
Baculoviral IAP repeat-containing protein 2
86
Baculoviral IAP repeat-containing protein 2
86
9.8
61
0.17
Q13490Q13490['cell surface receptor signaling pathway', 'I-kappaB kinase/NF-kappaB signaling', 'necroptotic process', 'negative regulation of apoptotic process', 'negative regulation of necroptotic process', 'negative regulation of ripoptosome assembly involved in necroptotic process', 'NIK/NF-kappaB signaling', 'placenta development', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of protein K48-linked ubiquitination', 'positive regulation of protein K63-linked ubiquitination', 'positive regulation of protein monoubiquitination', 'positive regulation of protein ubiquitination', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein polyubiquitination', 'regulation of apoptotic process', 'regulation of cell cycle', 'regulation of cell differentiation', 'regulation of cell population proliferation', 'regulation of cysteine-type endopeptidase activity', 'regulation of inflammatory response', 'regulation of innate immune response', 'regulation of necroptotic process', 'regulation of NIK/NF-kappaB signaling', 'regulation of nucleotide-binding oligomerization domain containing signaling pathway', 'regulation of reactive oxygen species metabolic process', 'regulation of RIG-I signaling pathway', 'regulation of toll-like receptor signaling pathway', 'response to cAMP', 'response to ethanol', 'response to hypoxia', 'tumor necrosis factor-mediated signaling pathway']['cell surface receptor signaling pathway', 'I-kappaB kinase/NF-kappaB signaling', 'necroptotic process', 'negative regulation of apoptotic process', 'negative regulation of necroptotic process', 'negative regulation of ripoptosome assembly involved in necroptotic process', 'NIK/NF-kappaB signaling', 'placenta development', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of protein K48-linked ubiquitination', 'positive regulation of protein K63-linked ubiquitination', 'positive regulation of protein monoubiquitination', 'positive regulation of protein ubiquitination', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein polyubiquitination', 'regulation of apoptotic process', 'regulation of cell cycle', 'regulation of cell differentiation', 'regulation of cell population proliferation', 'regulation of cysteine-type endopeptidase activity', 'regulation of inflammatory response', 'regulation of innate immune response', 'regulation of necroptotic process', 'regulation of NIK/NF-kappaB signaling', 'regulation of nucleotide-binding oligomerization domain containing signaling pathway', 'regulation of reactive oxygen species metabolic process', 'regulation of RIG-I signaling pathway', 'regulation of toll-like receptor signaling pathway', 'response to cAMP', 'response to ethanol', 'response to hypoxia', 'tumor necrosis factor-mediated signaling pathway']
Fibrinogen gamma-B chain
43
Fibrinogen gamma-B chain
32
8.1
80
0.15
P12799P12799['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'platelet aggregation', 'protein polymerization']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'platelet aggregation', 'protein polymerization']
Bromodomain adjacent to zinc finger domain protein 2B
827
Bromodomain adjacent to zinc finger domain protein 2B
827
2.1
75
0.64
Q9UIF8Q9UIF8['chromatin remodeling', 'regulation of transcription by RNA polymerase II']['chromatin remodeling', 'regulation of transcription by RNA polymerase II']
DNA ligase 4
137
DNA ligase 4
137
2.1
73
0.66
P49917P49917['cell cycle', 'cell division', 'cell population proliferation', 'cellular response to ionizing radiation', 'cellular response to lithium ion', 'central nervous system development', 'chromosome organization', 'DN2 thymocyte differentiation', 'DNA biosynthetic process', 'DNA ligation', 'DNA ligation involved in DNA recombination', 'DNA ligation involved in DNA repair', 'DNA replication', 'double-strand break repair', 'double-strand break repair via classical nonhomologous end joining', 'double-strand break repair via nonhomologous end joining', 'establishment of integrated proviral latency', 'fibroblast proliferation', 'immunoglobulin V(D)J recombination', 'in utero embryonic development', 'isotype switching', 'negative regulation of neuron apoptotic process', 'neurogenesis', 'neuron apoptotic process', 'nucleotide-excision repair, DNA gap filling', 'positive regulation of chromosome organization', 'positive regulation of fibroblast proliferation', 'positive regulation of neurogenesis', 'pro-B cell differentiation', 'response to gamma radiation', 'response to X-ray', 'single strand break repair', 'somatic stem cell population maintenance', 'stem cell proliferation', 'T cell differentiation in thymus', 'T cell receptor V(D)J recombination', 'V(D)J recombination']['cell cycle', 'cell division', 'cell population proliferation', 'cellular response to ionizing radiation', 'cellular response to lithium ion', 'central nervous system development', 'chromosome organization', 'DN2 thymocyte differentiation', 'DNA biosynthetic process', 'DNA ligation', 'DNA ligation involved in DNA recombination', 'DNA ligation involved in DNA repair', 'DNA replication', 'double-strand break repair', 'double-strand break repair via classical nonhomologous end joining', 'double-strand break repair via nonhomologous end joining', 'establishment of integrated proviral latency', 'fibroblast proliferation', 'immunoglobulin V(D)J recombination', 'in utero embryonic development', 'isotype switching', 'negative regulation of neuron apoptotic process', 'neurogenesis', 'neuron apoptotic process', 'nucleotide-excision repair, DNA gap filling', 'positive regulation of chromosome organization', 'positive regulation of fibroblast proliferation', 'positive regulation of neurogenesis', 'pro-B cell differentiation', 'response to gamma radiation', 'response to X-ray', 'single strand break repair', 'somatic stem cell population maintenance', 'stem cell proliferation', 'T cell differentiation in thymus', 'T cell receptor V(D)J recombination', 'V(D)J recombination']
Coagulation factor XI
416
Amyloid-beta precursor protein
300
9.1
99
0.11
P03951P05067['blood coagulation', 'blood coagulation, intrinsic pathway', 'plasminogen activation', 'positive regulation of fibrinolysis', 'proteolysis', 'zymogen activation']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Adhesion G protein-coupled receptor L3
191
Adhesion G protein-coupled receptor L3
191
9.2
59
0.19
Q80TS3Q80TS3['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'brain development', 'cell surface receptor signaling pathway', 'cell-cell adhesion via plasma-membrane adhesion molecules', 'locomotion involved in locomotory behavior', 'neuron migration', 'positive regulation of synapse assembly', 'response to cocaine', 'synapse assembly', 'synapse organization']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'brain development', 'cell surface receptor signaling pathway', 'cell-cell adhesion via plasma-membrane adhesion molecules', 'locomotion involved in locomotory behavior', 'neuron migration', 'positive regulation of synapse assembly', 'response to cocaine', 'synapse assembly', 'synapse organization']
Interleukin-10
132
Interleukin-10
80
9.1
78
0.14
P18893P18893['aging', 'branching involved in labyrinthine layer morphogenesis', 'cellular response to estradiol stimulus', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to lipopolysaccharide', 'chronic inflammatory response to antigenic stimulus', 'defense response to bacterium', 'defense response to protozoan', 'immune response', 'liver regeneration', 'negative regulation of apoptotic process', 'negative regulation of autophagy', 'negative regulation of B cell proliferation', 'negative regulation of cell population proliferation', 'negative regulation of chronic inflammatory response to antigenic stimulus', 'negative regulation of cytokine activity', 'negative regulation of cytokine production', 'negative regulation of cytokine production involved in immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of heterotypic cell-cell adhesion', 'negative regulation of hydrogen peroxide-induced neuron death', 'negative regulation of inflammatory response', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-12 production', 'negative regulation of interleukin-6 production', 'negative regulation of membrane protein ectodomain proteolysis', 'negative regulation of MHC class II biosynthetic process', 'negative regulation of myeloid dendritic cell activation', 'negative regulation of neuron apoptotic process', 'negative regulation of nitric oxide biosynthetic process', 'negative regulation of sensory perception of pain', 'negative regulation of tumor necrosis factor production', 'negative regulation of vascular associated smooth muscle cell proliferation', 'positive regulation of B cell apoptotic process', 'positive regulation of cell cycle', 'positive regulation of cytokine production', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell proliferation', 'positive regulation of immunoglobulin production', 'positive regulation of macrophage activation', 'positive regulation of MHC class II biosynthetic process', 'positive regulation of miRNA transcription', 'positive regulation of plasma cell differentiation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of signaling receptor activity', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of gene expression', 'regulation of response to wounding', 'regulation of sensory perception of pain', 'regulation of synapse organization', 'response to activity', 'response to carbon monoxide', 'response to glucocorticoid', 'response to inactivity', 'response to insulin', 'response to molecule of bacterial origin', 'response to xenobiotic stimulus']['aging', 'branching involved in labyrinthine layer morphogenesis', 'cellular response to estradiol stimulus', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to lipopolysaccharide', 'chronic inflammatory response to antigenic stimulus', 'defense response to bacterium', 'defense response to protozoan', 'immune response', 'liver regeneration', 'negative regulation of apoptotic process', 'negative regulation of autophagy', 'negative regulation of B cell proliferation', 'negative regulation of cell population proliferation', 'negative regulation of chronic inflammatory response to antigenic stimulus', 'negative regulation of cytokine activity', 'negative regulation of cytokine production', 'negative regulation of cytokine production involved in immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of heterotypic cell-cell adhesion', 'negative regulation of hydrogen peroxide-induced neuron death', 'negative regulation of inflammatory response', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-12 production', 'negative regulation of interleukin-6 production', 'negative regulation of membrane protein ectodomain proteolysis', 'negative regulation of MHC class II biosynthetic process', 'negative regulation of myeloid dendritic cell activation', 'negative regulation of neuron apoptotic process', 'negative regulation of nitric oxide biosynthetic process', 'negative regulation of sensory perception of pain', 'negative regulation of tumor necrosis factor production', 'negative regulation of vascular associated smooth muscle cell proliferation', 'positive regulation of B cell apoptotic process', 'positive regulation of cell cycle', 'positive regulation of cytokine production', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell proliferation', 'positive regulation of immunoglobulin production', 'positive regulation of macrophage activation', 'positive regulation of MHC class II biosynthetic process', 'positive regulation of miRNA transcription', 'positive regulation of plasma cell differentiation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of signaling receptor activity', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of gene expression', 'regulation of response to wounding', 'regulation of sensory perception of pain', 'regulation of synapse organization', 'response to activity', 'response to carbon monoxide', 'response to glucocorticoid', 'response to inactivity', 'response to insulin', 'response to molecule of bacterial origin', 'response to xenobiotic stimulus']
Histone deacetylase 6
1148
Histone deacetylase 6
1145
9.1
89
0.12
Q9UBN7Q9UBN7['aggresome assembly', 'autophagy', 'axonal transport of mitochondrion', 'cellular response to hydrogen peroxide', 'cellular response to misfolded protein', 'cellular response to topologically incorrect protein', 'cilium assembly', 'cilium disassembly', 'collateral sprouting', 'dendritic spine morphogenesis', 'histone deacetylation', 'Hsp90 deacetylation', 'intracellular protein transport', 'lysosome localization', 'negative regulation of hydrogen peroxide metabolic process', 'negative regulation of microtubule depolymerization', 'negative regulation of oxidoreductase activity', 'negative regulation of protein-containing complex assembly', 'negative regulation of protein-containing complex disassembly', 'negative regulation of proteolysis', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization', 'peptidyl-lysine deacetylation', 'polyubiquitinated misfolded protein transport', 'positive regulation of epithelial cell migration', 'positive regulation of hydrogen peroxide-mediated programmed cell death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of signaling receptor activity', 'protein deacetylation', 'protein destabilization', 'protein polyubiquitination', 'protein quality control for misfolded or incompletely synthesized proteins', 'protein-containing complex disassembly', 'regulation of androgen receptor signaling pathway', 'regulation of autophagy', 'regulation of autophagy of mitochondrion', 'regulation of establishment of protein localization', 'regulation of fat cell differentiation', 'regulation of gene expression, epigenetic', 'regulation of macroautophagy', 'regulation of microtubule-based movement', 'regulation of protein stability', 'response to growth factor', 'response to misfolded protein', 'tubulin deacetylation', 'ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway']['aggresome assembly', 'autophagy', 'axonal transport of mitochondrion', 'cellular response to hydrogen peroxide', 'cellular response to misfolded protein', 'cellular response to topologically incorrect protein', 'cilium assembly', 'cilium disassembly', 'collateral sprouting', 'dendritic spine morphogenesis', 'histone deacetylation', 'Hsp90 deacetylation', 'intracellular protein transport', 'lysosome localization', 'negative regulation of hydrogen peroxide metabolic process', 'negative regulation of microtubule depolymerization', 'negative regulation of oxidoreductase activity', 'negative regulation of protein-containing complex assembly', 'negative regulation of protein-containing complex disassembly', 'negative regulation of proteolysis', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization', 'peptidyl-lysine deacetylation', 'polyubiquitinated misfolded protein transport', 'positive regulation of epithelial cell migration', 'positive regulation of hydrogen peroxide-mediated programmed cell death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of signaling receptor activity', 'protein deacetylation', 'protein destabilization', 'protein polyubiquitination', 'protein quality control for misfolded or incompletely synthesized proteins', 'protein-containing complex disassembly', 'regulation of androgen receptor signaling pathway', 'regulation of autophagy', 'regulation of autophagy of mitochondrion', 'regulation of establishment of protein localization', 'regulation of fat cell differentiation', 'regulation of gene expression, epigenetic', 'regulation of macroautophagy', 'regulation of microtubule-based movement', 'regulation of protein stability', 'response to growth factor', 'response to misfolded protein', 'tubulin deacetylation', 'ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway']
Progesterone receptor
619
Progesterone receptor
619
9.2
79
0.14
P06401P06401['cell-cell signaling', 'glandular epithelial cell maturation', 'intracellular steroid hormone receptor signaling pathway', 'lung alveolus development', 'negative regulation of gene expression', 'ovulation from ovarian follicle', 'paracrine signaling', 'positive regulation of gene expression', 'positive regulation of transcription by RNA polymerase II', 'progesterone receptor signaling pathway', 'regulation of epithelial cell proliferation', 'regulation of transcription by RNA polymerase II', 'signal transduction', 'tertiary branching involved in mammary gland duct morphogenesis']['cell-cell signaling', 'glandular epithelial cell maturation', 'intracellular steroid hormone receptor signaling pathway', 'lung alveolus development', 'negative regulation of gene expression', 'ovulation from ovarian follicle', 'paracrine signaling', 'positive regulation of gene expression', 'positive regulation of transcription by RNA polymerase II', 'progesterone receptor signaling pathway', 'regulation of epithelial cell proliferation', 'regulation of transcription by RNA polymerase II', 'signal transduction', 'tertiary branching involved in mammary gland duct morphogenesis']
Glutamate receptor ionotropic, delta-1
80
Glutamate receptor ionotropic, delta-1
351
9.7
78
0.13
Q61627Q61627['modulation of chemical synaptic transmission', 'social behavior', 'synaptic transmission, glutamatergic']['modulation of chemical synaptic transmission', 'social behavior', 'synaptic transmission, glutamatergic']
Mineralocorticoid receptor
655
Mineralocorticoid receptor
655
9.2
78
0.14
P08235P08235['intracellular steroid hormone receptor signaling pathway', 'positive regulation of NIK/NF-kappaB signaling', 'regulation of transcription by RNA polymerase II', 'signal transduction']['intracellular steroid hormone receptor signaling pathway', 'positive regulation of NIK/NF-kappaB signaling', 'regulation of transcription by RNA polymerase II', 'signal transduction']
ATP-dependent RNA helicase DHX58
559
ATP-dependent RNA helicase DHX58
556
9.2
70
0.15
Q96C10Q96C10['cytoplasmic pattern recognition receptor signaling pathway in response to virus', 'innate immune response', 'negative regulation of innate immune response', 'negative regulation of MDA-5 signaling pathway', 'negative regulation of RIG-I signaling pathway', 'negative regulation of type I interferon production', 'positive regulation of interferon-beta production', 'positive regulation of MDA-5 signaling pathway', 'positive regulation of RIG-I signaling pathway', 'positive regulation of type I interferon production', 'regulation of innate immune response', 'response to bacterium', 'response to virus']['cytoplasmic pattern recognition receptor signaling pathway in response to virus', 'innate immune response', 'negative regulation of innate immune response', 'negative regulation of MDA-5 signaling pathway', 'negative regulation of RIG-I signaling pathway', 'negative regulation of type I interferon production', 'positive regulation of interferon-beta production', 'positive regulation of MDA-5 signaling pathway', 'positive regulation of RIG-I signaling pathway', 'positive regulation of type I interferon production', 'regulation of innate immune response', 'response to bacterium', 'response to virus']
Albumin
192
Albumin
538
9.7
69
0.15
P02768P02768['cellular response to starvation', 'maintenance of mitochondrion location', 'negative regulation of apoptotic process', 'negative regulation of programmed cell death', 'retina homeostasis']['cellular response to starvation', 'maintenance of mitochondrion location', 'negative regulation of apoptotic process', 'negative regulation of programmed cell death', 'retina homeostasis']
Glial cell line-derived neurotrophic factor
210
Glial cell line-derived neurotrophic factor
178
9.2
66
0.16
Q07731Q07731['branching involved in ureteric bud morphogenesis', 'cell population proliferation', 'cellular response to dexamethasone stimulus', 'commissural neuron axon guidance', 'dorsal spinal cord development', 'embryonic organ development', 'enteric nervous system development', 'male gonad development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'metanephros development', 'midbrain development', 'mRNA stabilization', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of neuron apoptotic process', 'nervous system development', 'neural crest cell migration', 'neuron differentiation', 'neuron projection development', 'organ induction', 'peripheral nervous system development', 'peristalsis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis', 'positive regulation of monooxygenase activity', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of ureteric bud formation', 'postganglionic parasympathetic fiber development', 'postsynaptic membrane organization', 'regulation of dopamine uptake involved in synaptic transmission', 'regulation of gene expression', 'regulation of morphogenesis of a branching structure', 'regulation of semaphorin-plexin signaling pathway', 'regulation of ureteric bud formation', 'response to wounding', 'retina development in camera-type eye', 'sympathetic nervous system development', 'ureteric bud development', 'ureteric bud formation']['branching involved in ureteric bud morphogenesis', 'cell population proliferation', 'cellular response to dexamethasone stimulus', 'commissural neuron axon guidance', 'dorsal spinal cord development', 'embryonic organ development', 'enteric nervous system development', 'male gonad development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'metanephros development', 'midbrain development', 'mRNA stabilization', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of neuron apoptotic process', 'nervous system development', 'neural crest cell migration', 'neuron differentiation', 'neuron projection development', 'organ induction', 'peripheral nervous system development', 'peristalsis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis', 'positive regulation of monooxygenase activity', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of ureteric bud formation', 'postganglionic parasympathetic fiber development', 'postsynaptic membrane organization', 'regulation of dopamine uptake involved in synaptic transmission', 'regulation of gene expression', 'regulation of morphogenesis of a branching structure', 'regulation of semaphorin-plexin signaling pathway', 'regulation of ureteric bud formation', 'response to wounding', 'retina development in camera-type eye', 'sympathetic nervous system development', 'ureteric bud development', 'ureteric bud formation']
E3 ubiquitin-protein ligase RNF31
885
E3 ubiquitin-protein ligase RNF31
885
9.1
42
0.26
Q96EP0Q96EP0['CD40 signaling pathway', 'defense response to bacterium', 'negative regulation of necroptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of xenophagy', 'protein linear polyubiquitination', 'protein polyubiquitination', 'T cell receptor signaling pathway']['CD40 signaling pathway', 'defense response to bacterium', 'negative regulation of necroptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of xenophagy', 'protein linear polyubiquitination', 'protein polyubiquitination', 'T cell receptor signaling pathway']
Glycoprotein hormones alpha chain
83
Follitropin subunit beta
50
9.1
78
0.14
P01215P01225['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Angiopoietin-related protein 2
443
Angiopoietin-related protein 2
443
9.1
85
0.13
Q9UKU9Q9UKU9['cell-cell signaling']['cell-cell signaling']
Progesterone receptor
619
Progesterone receptor
603
9.8
71
0.14
P06401P06401['cell-cell signaling', 'glandular epithelial cell maturation', 'intracellular steroid hormone receptor signaling pathway', 'lung alveolus development', 'negative regulation of gene expression', 'ovulation from ovarian follicle', 'paracrine signaling', 'positive regulation of gene expression', 'positive regulation of transcription by RNA polymerase II', 'progesterone receptor signaling pathway', 'regulation of epithelial cell proliferation', 'regulation of transcription by RNA polymerase II', 'signal transduction', 'tertiary branching involved in mammary gland duct morphogenesis']['cell-cell signaling', 'glandular epithelial cell maturation', 'intracellular steroid hormone receptor signaling pathway', 'lung alveolus development', 'negative regulation of gene expression', 'ovulation from ovarian follicle', 'paracrine signaling', 'positive regulation of gene expression', 'positive regulation of transcription by RNA polymerase II', 'progesterone receptor signaling pathway', 'regulation of epithelial cell proliferation', 'regulation of transcription by RNA polymerase II', 'signal transduction', 'tertiary branching involved in mammary gland duct morphogenesis']
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
122
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
122
9.1
77
0.14
Q8N5Z0Q8N5Z0['2-oxoglutarate metabolic process', 'alpha-amino acid metabolic process', 'biosynthetic process', 'glutamate metabolic process', 'kynurenine metabolic process', 'L-lysine catabolic process to acetyl-CoA via saccharopine']['2-oxoglutarate metabolic process', 'alpha-amino acid metabolic process', 'biosynthetic process', 'glutamate metabolic process', 'kynurenine metabolic process', 'L-lysine catabolic process to acetyl-CoA via saccharopine']
Rhodopsin
140
Guanine nucleotide-binding protein G(t) subunit alpha-3
351
9.8
65
0.16
P02699P0C7Q4['absorption of visible light', 'cellular response to light stimulus', 'detection of temperature stimulus involved in thermoception', 'G protein-coupled receptor signaling pathway', 'photoreceptor cell maintenance', 'phototransduction', 'phototransduction, visible light', 'protein phosphorylation', 'response to light stimulus', 'retina development in camera-type eye', 'rhodopsin mediated signaling pathway', 'thermotaxis', 'visual perception']['adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'detection of chemical stimulus involved in sensory perception of bitter taste', 'sensory perception of sweet taste', 'sensory perception of umami taste']
Asparaginase
79
Asparaginase
79
9.2
72
0.15
H0W0T5H0W0T5['aspartate family amino acid metabolic process']['aspartate family amino acid metabolic process']
Transforming growth factor beta-1 proprotein
355
Transforming growth factor beta-1 proprotein
389
9.2
78
0.14
P07200P07200['adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains', 'aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'branch elongation involved in mammary gland duct branching', 'bronchiole development', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'cellular calcium ion homeostasis', 'cellular response to ionizing radiation', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'chondrocyte differentiation', 'columnar/cuboidal epithelial cell maturation', 'common-partner SMAD protein phosphorylation', 'embryonic liver development', 'enamel mineralization', 'endoderm development', 'epidermal growth factor receptor signaling pathway', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'face morphogenesis', 'gene expression', 'germ cell migration', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'Langerhans cell differentiation', 'lens fiber cell differentiation', 'lipopolysaccharide-mediated signaling pathway', 'lung alveolus development', 'lymph node development', 'mammary gland branching involved in thelarche', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'muscle cell cellular homeostasis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of epithelial cell proliferation', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of interleukin-17 production', 'negative regulation of macrophage cytokine production', 'negative regulation of myoblast differentiation', 'negative regulation of ossification', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of T cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'Notch signaling pathway', 'oligodendrocyte development', 'ossification involved in bone remodeling', 'osteoclast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'phospholipid homeostasis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of histone acetylation', 'positive regulation of histone deacetylation', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of odontogenesis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor clustering', 'positive regulation of regulatory T cell differentiation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stem cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of actin cytoskeleton reorganization', 'regulation of binding', 'regulation of branching involved in mammary gland duct morphogenesis', 'regulation of cartilage development', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of interleukin-23 production', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of sodium ion transport', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulatory T cell differentiation', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'stem cell proliferation', 'surfactant homeostasis', 'T cell homeostasis', 'T cell proliferation', 'tolerance induction to self antigen', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'ureteric bud development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains', 'aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'branch elongation involved in mammary gland duct branching', 'bronchiole development', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'cellular calcium ion homeostasis', 'cellular response to ionizing radiation', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'chondrocyte differentiation', 'columnar/cuboidal epithelial cell maturation', 'common-partner SMAD protein phosphorylation', 'embryonic liver development', 'enamel mineralization', 'endoderm development', 'epidermal growth factor receptor signaling pathway', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'face morphogenesis', 'gene expression', 'germ cell migration', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'Langerhans cell differentiation', 'lens fiber cell differentiation', 'lipopolysaccharide-mediated signaling pathway', 'lung alveolus development', 'lymph node development', 'mammary gland branching involved in thelarche', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'muscle cell cellular homeostasis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of epithelial cell proliferation', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of interleukin-17 production', 'negative regulation of macrophage cytokine production', 'negative regulation of myoblast differentiation', 'negative regulation of ossification', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of T cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'Notch signaling pathway', 'oligodendrocyte development', 'ossification involved in bone remodeling', 'osteoclast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'phospholipid homeostasis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of histone acetylation', 'positive regulation of histone deacetylation', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of odontogenesis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor clustering', 'positive regulation of regulatory T cell differentiation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stem cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of actin cytoskeleton reorganization', 'regulation of binding', 'regulation of branching involved in mammary gland duct morphogenesis', 'regulation of cartilage development', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of interleukin-23 production', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of sodium ion transport', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulatory T cell differentiation', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'stem cell proliferation', 'surfactant homeostasis', 'T cell homeostasis', 'T cell proliferation', 'tolerance induction to self antigen', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'ureteric bud development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']
Tumor necrosis factor receptor superfamily member 14
75
Tumor necrosis factor receptor superfamily member 14
127
9.1
72
0.15
Q92956Q92956['adaptive immune response', 'cell surface receptor signaling pathway', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'immune response', 'innate immune response', 'negative regulation of adaptive immune memory response', 'negative regulation of alpha-beta T cell proliferation', 'positive regulation of cytokine production involved in immune response', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of T cell migration', 'T cell costimulation']['adaptive immune response', 'cell surface receptor signaling pathway', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'immune response', 'innate immune response', 'negative regulation of adaptive immune memory response', 'negative regulation of alpha-beta T cell proliferation', 'positive regulation of cytokine production involved in immune response', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of T cell migration', 'T cell costimulation']
Transient receptor potential cation channel subfamily M member 7
1606
Transient receptor potential cation channel subfamily M member 7
1606
9.2
79
0.14
Q923J1Q923J1['actomyosin structure organization', 'calcium ion transport', 'calcium-dependent cell-matrix adhesion', 'cation transmembrane transport', 'cellular magnesium ion homeostasis', 'divalent inorganic cation homeostasis', 'memory', 'necroptotic process', 'positive regulation of apoptotic process', 'protein autophosphorylation', 'protein phosphorylation', 'protein tetramerization']['actomyosin structure organization', 'calcium ion transport', 'calcium-dependent cell-matrix adhesion', 'cation transmembrane transport', 'cellular magnesium ion homeostasis', 'divalent inorganic cation homeostasis', 'memory', 'necroptotic process', 'positive regulation of apoptotic process', 'protein autophosphorylation', 'protein phosphorylation', 'protein tetramerization']
Male-specific lethal 1 homolog
221
E3 ubiquitin-protein ligase MSL2
107
9.7
59
0.17
Q68DK7Q9HCI7['chromatin organization', 'histone H4-K16 acetylation', 'positive regulation of transcription, DNA-templated', 'regulation of dosage compensation by inactivation of X chromosome']['histone H4-K16 acetylation', 'positive regulation of transcription, DNA-templated', 'protein ubiquitination', 'regulation of dosage compensation by inactivation of X chromosome']
Tyrosyl-DNA phosphodiesterase 2
311
Tyrosyl-DNA phosphodiesterase 2
137
9.8
68
0.15
O95551O95551['cell surface receptor signaling pathway', 'double-strand break repair', 'neuron development']['cell surface receptor signaling pathway', 'double-strand break repair', 'neuron development']
Anionic trypsin-2
48
Amyloid-beta precursor protein
300
9.1
95
0.12
P00763P05067['collagen catabolic process', 'digestion', 'proteolysis', 'response to nutrient']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Growth/differentiation factor 8
340
Growth/differentiation factor 8
341
8.4
82
0.14
O08689O08689['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['cellular response to dexamethasone stimulus', 'muscle cell cellular homeostasis', 'myoblast migration involved in skeletal muscle regeneration', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of kinase activity', 'negative regulation of muscle hypertrophy', 'negative regulation of myoblast differentiation', 'negative regulation of myoblast proliferation', 'negative regulation of protein kinase B signaling', 'negative regulation of satellite cell differentiation', 'negative regulation of skeletal muscle satellite cell proliferation', 'negative regulation of skeletal muscle tissue growth', 'ovulation cycle process', 'positive regulation of lamellipodium assembly', 'positive regulation of macrophage chemotaxis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription, DNA-templated', 'response to electrical stimulus', 'response to estrogen', 'response to ethanol', 'response to gravity', 'response to heat', 'response to muscle activity', 'response to testosterone', 'skeletal muscle atrophy', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
Defensin alpha 5
82
Defensin alpha 5
65
8.4
67
0.18
Q01523Q01523['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']
Glycoprotein hormones alpha chain
31
Follitropin subunit beta
69
9.9
60
0.17
P01215P01225['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Defensin alpha 4
67
Defensin alpha 4
82
7.1
77
0.18
P12838P12838['antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'antimicrobial humoral response', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism', 'T cell chemotaxis']['antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'antimicrobial humoral response', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism', 'T cell chemotaxis']
Amyloid-beta precursor protein
291
Amyloid-beta precursor protein
337
7.1
55
0.26
P05067P05067['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
S-phase kinase-associated protein 2
113
S-phase kinase-associated protein 1
160
8.2
nan
nan
Q13309P63208['defense response to virus', 'G1/S transition of mitotic cell cycle', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'positive regulation of intracellular estrogen receptor signaling pathway', 'positive regulation of protein polyubiquitination', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein K48-linked ubiquitination', 'regulation of apoptotic process', 'regulation of cell cycle', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process']['histone H2A monoubiquitination', 'maintenance of protein location in nucleus', 'positive regulation of ubiquitin protein ligase activity', 'protein K48-linked ubiquitination', 'protein polyubiquitination', 'protein ubiquitination', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process']
Breast cancer metastasis-suppressor 1
60
Breast cancer metastasis-suppressor 1
60
2.0
52
0.96
Q9HCU9Q9HCU9['apoptotic process', 'histone deacetylation', 'negative regulation of cell migration', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of stem cell population maintenance', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'positive regulation of anoikis', 'positive regulation of protein deacetylation', 'positive regulation of stem cell population maintenance', 'regulation of apoptotic process']['apoptotic process', 'histone deacetylation', 'negative regulation of cell migration', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of stem cell population maintenance', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'positive regulation of anoikis', 'positive regulation of protein deacetylation', 'positive regulation of stem cell population maintenance', 'regulation of apoptotic process']
NKG2-D type II integral membrane protein
99
NKG2-D type II integral membrane protein
96
7.9
68
0.19
P26718P26718['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of interferon-gamma production', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of nitric oxide biosynthetic process', 'signal transduction', 'stimulatory C-type lectin receptor signaling pathway', 'T cell costimulation']['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of interferon-gamma production', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of nitric oxide biosynthetic process', 'signal transduction', 'stimulatory C-type lectin receptor signaling pathway', 'T cell costimulation']
Neurogenic locus notch homolog protein 3
1500
Neurogenic locus notch homolog protein 3
1484
7.9
57
0.22
Q9UM47Q9UM47['artery morphogenesis', 'axon guidance', 'forebrain development', 'glomerular capillary formation', 'negative regulation of neuron differentiation', 'negative regulation of transcription by RNA polymerase II', 'neuroblast differentiation', 'neuron fate commitment', 'Notch signaling pathway', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II']['artery morphogenesis', 'axon guidance', 'forebrain development', 'glomerular capillary formation', 'negative regulation of neuron differentiation', 'negative regulation of transcription by RNA polymerase II', 'neuroblast differentiation', 'neuron fate commitment', 'Notch signaling pathway', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II']
Histone deacetylase 6
1120
Histone deacetylase 6
1113
8.5
69
0.17
Q9UBN7Q9UBN7['aggresome assembly', 'autophagy', 'axonal transport of mitochondrion', 'cellular response to hydrogen peroxide', 'cellular response to misfolded protein', 'cellular response to topologically incorrect protein', 'cilium assembly', 'cilium disassembly', 'collateral sprouting', 'dendritic spine morphogenesis', 'histone deacetylation', 'Hsp90 deacetylation', 'intracellular protein transport', 'lysosome localization', 'negative regulation of hydrogen peroxide metabolic process', 'negative regulation of microtubule depolymerization', 'negative regulation of oxidoreductase activity', 'negative regulation of protein-containing complex assembly', 'negative regulation of protein-containing complex disassembly', 'negative regulation of proteolysis', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization', 'peptidyl-lysine deacetylation', 'polyubiquitinated misfolded protein transport', 'positive regulation of epithelial cell migration', 'positive regulation of hydrogen peroxide-mediated programmed cell death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of signaling receptor activity', 'protein deacetylation', 'protein destabilization', 'protein polyubiquitination', 'protein quality control for misfolded or incompletely synthesized proteins', 'protein-containing complex disassembly', 'regulation of androgen receptor signaling pathway', 'regulation of autophagy', 'regulation of autophagy of mitochondrion', 'regulation of establishment of protein localization', 'regulation of fat cell differentiation', 'regulation of gene expression, epigenetic', 'regulation of macroautophagy', 'regulation of microtubule-based movement', 'regulation of protein stability', 'response to growth factor', 'response to misfolded protein', 'tubulin deacetylation', 'ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway']['aggresome assembly', 'autophagy', 'axonal transport of mitochondrion', 'cellular response to hydrogen peroxide', 'cellular response to misfolded protein', 'cellular response to topologically incorrect protein', 'cilium assembly', 'cilium disassembly', 'collateral sprouting', 'dendritic spine morphogenesis', 'histone deacetylation', 'Hsp90 deacetylation', 'intracellular protein transport', 'lysosome localization', 'negative regulation of hydrogen peroxide metabolic process', 'negative regulation of microtubule depolymerization', 'negative regulation of oxidoreductase activity', 'negative regulation of protein-containing complex assembly', 'negative regulation of protein-containing complex disassembly', 'negative regulation of proteolysis', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization', 'peptidyl-lysine deacetylation', 'polyubiquitinated misfolded protein transport', 'positive regulation of epithelial cell migration', 'positive regulation of hydrogen peroxide-mediated programmed cell death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of signaling receptor activity', 'protein deacetylation', 'protein destabilization', 'protein polyubiquitination', 'protein quality control for misfolded or incompletely synthesized proteins', 'protein-containing complex disassembly', 'regulation of androgen receptor signaling pathway', 'regulation of autophagy', 'regulation of autophagy of mitochondrion', 'regulation of establishment of protein localization', 'regulation of fat cell differentiation', 'regulation of gene expression, epigenetic', 'regulation of macroautophagy', 'regulation of microtubule-based movement', 'regulation of protein stability', 'response to growth factor', 'response to misfolded protein', 'tubulin deacetylation', 'ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway']
Defensin alpha 4
67
Defensin alpha 4
93
7.9
64
0.2
P12838P12838['antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'antimicrobial humoral response', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism', 'T cell chemotaxis']['antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'antimicrobial humoral response', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism', 'T cell chemotaxis']
Endothelin-1
53
Endothelin-1
63
3.7
56
0.48
P05305P05305['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'artery smooth muscle contraction', 'axon extension', 'axonogenesis involved in innervation', 'body fluid secretion', 'branching involved in blood vessel morphogenesis', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cardiac neural crest cell migration involved in outflow tract morphogenesis', 'cartilage development', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to calcium ion', 'cellular response to fatty acid', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to human chorionic gonadotropin stimulus', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to luteinizing hormone stimulus', 'cellular response to mineralocorticoid stimulus', 'cellular response to organic substance', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to xenobiotic stimulus', 'dorsal/ventral pattern formation', 'embryonic heart tube development', 'endothelin receptor signaling pathway', 'endothelin receptor signaling pathway involved in heart process', 'epithelial fluid transport', 'ERK1 and ERK2 cascade', 'G protein-coupled receptor signaling pathway', 'histamine secretion', 'I-kappaB kinase/NF-kappaB signaling', 'in utero embryonic development', 'inositol phosphate-mediated signaling', 'leukocyte activation', 'maternal process involved in parturition', 'meiotic cell cycle process involved in oocyte maturation', 'membrane depolarization', 'middle ear morphogenesis', 'mitochondrion organization', 'multicellular organism aging', 'negative regulation of blood coagulation', 'negative regulation of gene expression', 'negative regulation of hormone secretion', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein metabolic process', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'neural crest cell fate commitment', 'nitric oxide transport', 'noradrenergic neuron differentiation', 'peptide hormone secretion', 'pharyngeal arch artery morphogenesis', 'phosphatidylinositol 3-kinase signaling', 'phospholipase D-activating G protein-coupled receptor signaling pathway', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cation channel activity', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell size', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell migration', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of JUN kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of odontogenesis', 'positive regulation of prostaglandin secretion', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'positive regulation of renal sodium excretion', 'positive regulation of sarcomere organization', 'positive regulation of signaling receptor activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'prostaglandin biosynthetic process', 'protein kinase A signaling', 'protein kinase C deactivation', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'regulation of glucose transmembrane transport', 'regulation of pH', 'regulation of sensory perception of pain', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'renal sodium ion absorption', 'respiratory gaseous exchange by respiratory system', 'response to activity', 'response to amino acid', 'response to amphetamine', 'response to dexamethasone', 'response to leptin', 'response to lipopolysaccharide', 'response to muscle stretch', 'response to nicotine', 'response to ozone', 'response to prostaglandin F', 'response to salt', 'response to testosterone', 'rhythmic excitation', 'semaphorin-plexin signaling pathway involved in axon guidance', 'sensory perception of pain', 'superoxide anion generation', 'sympathetic neuron axon guidance', 'thyroid gland development', 'transcription by RNA polymerase II', 'vasoconstriction', 'vein smooth muscle contraction']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'artery smooth muscle contraction', 'axon extension', 'axonogenesis involved in innervation', 'body fluid secretion', 'branching involved in blood vessel morphogenesis', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cardiac neural crest cell migration involved in outflow tract morphogenesis', 'cartilage development', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to calcium ion', 'cellular response to fatty acid', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to human chorionic gonadotropin stimulus', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to luteinizing hormone stimulus', 'cellular response to mineralocorticoid stimulus', 'cellular response to organic substance', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to xenobiotic stimulus', 'dorsal/ventral pattern formation', 'embryonic heart tube development', 'endothelin receptor signaling pathway', 'endothelin receptor signaling pathway involved in heart process', 'epithelial fluid transport', 'ERK1 and ERK2 cascade', 'G protein-coupled receptor signaling pathway', 'histamine secretion', 'I-kappaB kinase/NF-kappaB signaling', 'in utero embryonic development', 'inositol phosphate-mediated signaling', 'leukocyte activation', 'maternal process involved in parturition', 'meiotic cell cycle process involved in oocyte maturation', 'membrane depolarization', 'middle ear morphogenesis', 'mitochondrion organization', 'multicellular organism aging', 'negative regulation of blood coagulation', 'negative regulation of gene expression', 'negative regulation of hormone secretion', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein metabolic process', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'neural crest cell fate commitment', 'nitric oxide transport', 'noradrenergic neuron differentiation', 'peptide hormone secretion', 'pharyngeal arch artery morphogenesis', 'phosphatidylinositol 3-kinase signaling', 'phospholipase D-activating G protein-coupled receptor signaling pathway', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cation channel activity', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell size', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell migration', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of JUN kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of odontogenesis', 'positive regulation of prostaglandin secretion', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'positive regulation of renal sodium excretion', 'positive regulation of sarcomere organization', 'positive regulation of signaling receptor activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'prostaglandin biosynthetic process', 'protein kinase A signaling', 'protein kinase C deactivation', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'regulation of glucose transmembrane transport', 'regulation of pH', 'regulation of sensory perception of pain', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'renal sodium ion absorption', 'respiratory gaseous exchange by respiratory system', 'response to activity', 'response to amino acid', 'response to amphetamine', 'response to dexamethasone', 'response to leptin', 'response to lipopolysaccharide', 'response to muscle stretch', 'response to nicotine', 'response to ozone', 'response to prostaglandin F', 'response to salt', 'response to testosterone', 'rhythmic excitation', 'semaphorin-plexin signaling pathway involved in axon guidance', 'sensory perception of pain', 'superoxide anion generation', 'sympathetic neuron axon guidance', 'thyroid gland development', 'transcription by RNA polymerase II', 'vasoconstriction', 'vein smooth muscle contraction']
Natural killer cells antigen CD94
61
NKG2-A/NKG2-B type II integral membrane protein
116
7.1
59
0.24
Q13241P26715['adaptive immune response', 'cell surface receptor signaling pathway', 'natural killer cell mediated immunity', 'negative regulation of natural killer cell mediated cytotoxicity', 'negative regulation of T cell mediated cytotoxicity', 'positive regulation of natural killer cell mediated cytotoxicity', 'regulation of natural killer cell activation', 'stimulatory C-type lectin receptor signaling pathway']['adaptive immune response', 'CD8-positive, gamma-delta intraepithelial T cell differentiation', 'cell surface receptor signaling pathway', 'innate immune response', 'natural killer cell inhibitory signaling pathway', 'negative regulation of natural killer cell mediated cytotoxicity', 'negative regulation of T cell mediated cytotoxicity', 'regulation of natural killer cell activation']
Neuroblastoma suppressor of tumorigenicity 1
123
Neuroblastoma suppressor of tumorigenicity 1
82
3.7
68
0.4
P41271P41271['animal organ morphogenesis', 'determination of dorsal identity', 'negative regulation of BMP signaling pathway', 'negative regulation of monocyte chemotaxis', 'nervous system development', 'neuron projection morphogenesis', 'positive regulation of neuron differentiation', 'sequestering of BMP from receptor via BMP binding', 'sequestering of BMP in extracellular matrix']['animal organ morphogenesis', 'determination of dorsal identity', 'negative regulation of BMP signaling pathway', 'negative regulation of monocyte chemotaxis', 'nervous system development', 'neuron projection morphogenesis', 'positive regulation of neuron differentiation', 'sequestering of BMP from receptor via BMP binding', 'sequestering of BMP in extracellular matrix']
Histone-lysine N-methyltransferase 2C
1057
Histone-lysine N-methyltransferase 2C
1069
7.6
65
0.2
Q8NEZ4Q8NEZ4['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']
Biglycan
64
Biglycan
188
9.9
67
0.15
P21809P21809['articular cartilage development', 'bone development', 'peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan']['articular cartilage development', 'bone development', 'peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan']
cAMP-dependent protein kinase type I-beta regulatory subunit
39
cAMP-dependent protein kinase type I-beta regulatory subunit
18
2.0
46
1.08
P31321P31321['learning or memory', 'negative regulation of cAMP-dependent protein kinase activity', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of fear response', 'positive regulation of long-term synaptic potentiation', 'positive regulation of sensory perception of pain', 'protein phosphorylation', 'regulation of synaptic vesicle cycle']['learning or memory', 'negative regulation of cAMP-dependent protein kinase activity', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of fear response', 'positive regulation of long-term synaptic potentiation', 'positive regulation of sensory perception of pain', 'protein phosphorylation', 'regulation of synaptic vesicle cycle']
Bone morphogenetic protein 10
323
Bone morphogenetic protein 10
388
9.9
75
0.13
O95393O95393['activin receptor signaling pathway', 'adult heart development', 'atrial cardiac muscle tissue morphogenesis', 'BMP signaling pathway', 'cardiac muscle cell proliferation', 'cell adhesion', 'heart trabecula formation', 'kidney development', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of endothelial cell migration', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cartilage development', 'positive regulation of cell proliferation involved in heart morphogenesis', 'positive regulation of gene expression', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of sarcomere organization', 'positive regulation of transcription, DNA-templated', 'regulation of cardiac muscle contraction', 'regulation of cardiac muscle hypertrophy in response to stress', 'sarcomere organization', 'SMAD protein signal transduction', 'ventricular cardiac muscle cell development', 'ventricular cardiac muscle tissue morphogenesis']['activin receptor signaling pathway', 'adult heart development', 'atrial cardiac muscle tissue morphogenesis', 'BMP signaling pathway', 'cardiac muscle cell proliferation', 'cell adhesion', 'heart trabecula formation', 'kidney development', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of endothelial cell migration', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cartilage development', 'positive regulation of cell proliferation involved in heart morphogenesis', 'positive regulation of gene expression', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of sarcomere organization', 'positive regulation of transcription, DNA-templated', 'regulation of cardiac muscle contraction', 'regulation of cardiac muscle hypertrophy in response to stress', 'sarcomere organization', 'SMAD protein signal transduction', 'ventricular cardiac muscle cell development', 'ventricular cardiac muscle tissue morphogenesis']
Protein cereblon
346
Protein cereblon
329
8.4
44
0.27
Q8C7D2Q8C7D2['locomotory exploration behavior', 'negative regulation of ion transmembrane transport', 'negative regulation of large conductance calcium-activated potassium channel activity', 'negative regulation of protein-containing complex assembly', 'positive regulation of protein-containing complex assembly', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination']['locomotory exploration behavior', 'negative regulation of ion transmembrane transport', 'negative regulation of large conductance calcium-activated potassium channel activity', 'negative regulation of protein-containing complex assembly', 'positive regulation of protein-containing complex assembly', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination']
Glutamate receptor 2
330
Glutamate receptor 2
78
9.2
71
0.15
P42262P42262['chemical synaptic transmission', 'ionotropic glutamate receptor signaling pathway', 'signal transduction', 'synaptic transmission, glutamatergic']['chemical synaptic transmission', 'ionotropic glutamate receptor signaling pathway', 'signal transduction', 'synaptic transmission, glutamatergic']
Fibrinogen gamma chain
34
Fibrinogen gamma chain
35
2.0
39
1.26
P02679P02679['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Insulin-like growth factor I
96
Insulin-like growth factor-binding protein 1
176
7.5
70
0.19
P05019P08833['activation of protein kinase B activity', 'bone mineralization involved in bone maturation', 'cell activation', 'cell population proliferation', 'cellular response to amyloid-beta', 'ERK1 and ERK2 cascade', 'glycolate metabolic process', 'insulin-like growth factor receptor signaling pathway', 'muscle hypertrophy', 'muscle organ development', 'myoblast differentiation', 'myoblast proliferation', 'myotube cell development', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of gene expression', 'negative regulation of interleukin-1 beta production', 'negative regulation of neuroinflammatory response', 'negative regulation of oocyte development', 'negative regulation of release of cytochrome c from mitochondria', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of tumor necrosis factor production', 'negative regulation of vascular associated smooth muscle cell apoptotic process', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol-mediated signaling', 'positive regulation of activated T cell proliferation', 'positive regulation of calcineurin-NFAT signaling cascade', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of DNA binding', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Ras protein signal transduction', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of trophectodermal cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase B signaling', 'protein stabilization', 'proteoglycan biosynthetic process', 'Ras protein signal transduction', 'regulation of gene expression', 'regulation of multicellular organism growth', 'regulation of protein phosphorylation', 'response to heat', 'signal transduction', 'skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration', 'skeletal system development', 'wound healing']['aging', 'insulin receptor signaling pathway', 'negative regulation of canonical Wnt signaling pathway', 'positive regulation of cell growth', 'regulation of insulin-like growth factor receptor signaling pathway', 'signal transduction', 'tissue regeneration']
Lysine-specific histone demethylase 2
278
Lysine-specific histone demethylase 2
53
9.6
60
0.17
Q8NB78Q8NB78['DNA methylation involved in gamete generation', 'histone H3-K4 demethylation', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase II', 'regulation of DNA methylation', 'regulation of gene expression by genomic imprinting']['DNA methylation involved in gamete generation', 'histone H3-K4 demethylation', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase II', 'regulation of DNA methylation', 'regulation of gene expression by genomic imprinting']
Glutamate receptor 3
334
Glutamate receptor 3
85
9.6
68
0.15
P19492P19492['regulation of receptor recycling', 'response to fungicide', 'response to lithium ion']['regulation of receptor recycling', 'response to fungicide', 'response to lithium ion']
Amyloid beta precursor like protein 2
310
Amyloid beta precursor like protein 2
356
7.5
53
0.25
Q06481Q06481['axonogenesis', 'central nervous system development', 'G protein-coupled receptor signaling pathway', 'regulation of cellular protein metabolic process']['axonogenesis', 'central nervous system development', 'G protein-coupled receptor signaling pathway', 'regulation of cellular protein metabolic process']
Defensin alpha 5
93
Defensin alpha 5
65
9.6
59
0.18
Q01523Q01523['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']
Nesprin-4
382
Nesprin-4
382
2.8
42
0.85
Q8N205Q8N205['establishment of epithelial cell apical/basal polarity']['establishment of epithelial cell apical/basal polarity']
Defensin alpha 4
93
Defensin alpha 4
82
9.2
59
0.18
P12838P12838['antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'antimicrobial humoral response', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism', 'T cell chemotaxis']['antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'antimicrobial humoral response', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism', 'T cell chemotaxis']
Amyloid-beta precursor protein
291
Amyloid-beta precursor protein
316
7.5
60
0.22
P05067P05067['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Histone-lysine N-methyltransferase 2C
1057
Histone-lysine N-methyltransferase 2C
1081
7.3
71
0.19
Q8NEZ4Q8NEZ4['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']
Fibrinogen beta chain
110
Fibrinogen gamma chain
34
7.3
62
0.22
P02675P02679['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Neutrophil defensin 3
68
Neutrophil defensin 3
94
7.3
nan
nan
P59666P59666['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to virus', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing of cells of another organism', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to virus', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing of cells of another organism', 'membrane disruption in another organism']
Neutrophil defensin 1
68
Neutrophil defensin 1
94
7.8
nan
nan
P59665P59665['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']
Uteroglobin
90
Uteroglobin
24
2.0
46
1.08
P02779P02779['signal transduction']['signal transduction']
Amyloid-beta precursor protein
174
Amyloid-beta precursor protein
187
8.2
79
0.15
P05067P05067['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Bone morphogenetic protein 6
412
Bone morphogenetic protein 6
477
8.2
76
0.16
P22004P22004['BMP signaling pathway', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'cellular response to iron ion', 'cellular response to mechanical stimulus', 'endochondral ossification', 'eye development', 'immune response', 'inflammatory response', 'kidney development', 'male genitalia development', 'multicellular organismal iron ion homeostasis', 'negative regulation of adherens junction organization', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of transcription by RNA polymerase II', 'neuron differentiation', 'osteoblast differentiation', 'positive regulation of aldosterone biosynthetic process', 'positive regulation of aldosterone secretion', 'positive regulation of bone mineralization', 'positive regulation of cell population proliferation', 'positive regulation of chondrocyte differentiation', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of gene expression', 'positive regulation of lipopolysaccharide-mediated signaling pathway', 'positive regulation of neuron differentiation', 'positive regulation of osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vascular permeability', 'response to activity', 'response to glucocorticoid', 'response to magnesium ion', 'response to retinoic acid', 'skeletal system development', 'SMAD protein signal transduction', 'type B pancreatic cell development']['BMP signaling pathway', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'cellular response to iron ion', 'cellular response to mechanical stimulus', 'endochondral ossification', 'eye development', 'immune response', 'inflammatory response', 'kidney development', 'male genitalia development', 'multicellular organismal iron ion homeostasis', 'negative regulation of adherens junction organization', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of transcription by RNA polymerase II', 'neuron differentiation', 'osteoblast differentiation', 'positive regulation of aldosterone biosynthetic process', 'positive regulation of aldosterone secretion', 'positive regulation of bone mineralization', 'positive regulation of cell population proliferation', 'positive regulation of chondrocyte differentiation', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of gene expression', 'positive regulation of lipopolysaccharide-mediated signaling pathway', 'positive regulation of neuron differentiation', 'positive regulation of osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vascular permeability', 'response to activity', 'response to glucocorticoid', 'response to magnesium ion', 'response to retinoic acid', 'skeletal system development', 'SMAD protein signal transduction', 'type B pancreatic cell development']
F-box only protein 11
865
F-box only protein 11
899
7.1
55
0.25
Q86XK2Q86XK2['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']
C-C motif chemokine 17
33
C-C motif chemokine 17
33
7.9
78
0.16
Q92583Q92583['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation of myoblast differentiation', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation of myoblast differentiation', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']
Protein AF-9
5
Protein AF-9
5
2.0
63
0.79
P42568P42568['anterior/posterior pattern specification', 'chromatin remodeling', 'gene expression', 'hematopoietic stem cell differentiation', 'histone acetylation', 'negative regulation of canonical Wnt signaling pathway', 'positive regulation of transcription, DNA-templated', 'positive regulation of Wnt signaling pathway, planar cell polarity pathway', 'regulation of chromatin organization', 'regulation of stem cell division', 'regulation of transcription by RNA polymerase II', 'segment specification']['anterior/posterior pattern specification', 'chromatin remodeling', 'gene expression', 'hematopoietic stem cell differentiation', 'histone acetylation', 'negative regulation of canonical Wnt signaling pathway', 'positive regulation of transcription, DNA-templated', 'positive regulation of Wnt signaling pathway, planar cell polarity pathway', 'regulation of chromatin organization', 'regulation of stem cell division', 'regulation of transcription by RNA polymerase II', 'segment specification']
Low affinity immunoglobulin epsilon Fc receptor
160
Low affinity immunoglobulin epsilon Fc receptor
288
7.9
66
0.19
P06734P06734['positive regulation of humoral immune response mediated by circulating immunoglobulin', 'positive regulation of killing of cells of another organism', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of nitric-oxide synthase biosynthetic process']['positive regulation of humoral immune response mediated by circulating immunoglobulin', 'positive regulation of killing of cells of another organism', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of nitric-oxide synthase biosynthetic process']
Natural killer cells antigen CD94
59
NKG2-A/NKG2-B type II integral membrane protein
130
8.3
65
0.19
Q13241P26715['adaptive immune response', 'cell surface receptor signaling pathway', 'natural killer cell mediated immunity', 'negative regulation of natural killer cell mediated cytotoxicity', 'negative regulation of T cell mediated cytotoxicity', 'positive regulation of natural killer cell mediated cytotoxicity', 'regulation of natural killer cell activation', 'stimulatory C-type lectin receptor signaling pathway']['adaptive immune response', 'CD8-positive, gamma-delta intraepithelial T cell differentiation', 'cell surface receptor signaling pathway', 'innate immune response', 'natural killer cell inhibitory signaling pathway', 'negative regulation of natural killer cell mediated cytotoxicity', 'negative regulation of T cell mediated cytotoxicity', 'regulation of natural killer cell activation']
Transforming growth factor beta-1 proprotein
223
Transforming growth factor beta-1 proprotein
225
2.0
39
1.26
P01137P01137['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']
Pro-cathepsin H
327
Pro-cathepsin H
102
2.0
94
0.52
O46427O46427['bradykinin catabolic process', 'cellular response to thyroid hormone stimulus', 'dichotomous subdivision of terminal units involved in lung branching', 'ERK1 and ERK2 cascade', 'immune response-regulating signaling pathway', 'membrane protein proteolysis', 'metanephros development', 'negative regulation of apoptotic process', 'neuropeptide catabolic process', 'positive regulation of angiogenesis', 'positive regulation of apoptotic signaling pathway', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of gene expression', 'positive regulation of peptidase activity', 'protein destabilization', 'proteolysis', 'proteolysis involved in protein catabolic process', 'response to retinoic acid', 'surfactant homeostasis', 'T cell mediated cytotoxicity', 'zymogen activation']['bradykinin catabolic process', 'cellular response to thyroid hormone stimulus', 'dichotomous subdivision of terminal units involved in lung branching', 'ERK1 and ERK2 cascade', 'immune response-regulating signaling pathway', 'membrane protein proteolysis', 'metanephros development', 'negative regulation of apoptotic process', 'neuropeptide catabolic process', 'positive regulation of angiogenesis', 'positive regulation of apoptotic signaling pathway', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of gene expression', 'positive regulation of peptidase activity', 'protein destabilization', 'proteolysis', 'proteolysis involved in protein catabolic process', 'response to retinoic acid', 'surfactant homeostasis', 'T cell mediated cytotoxicity', 'zymogen activation']
F-box only protein 11
890
F-box only protein 11
856
7.3
63
0.22
Q86XK2Q86XK2['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']
Histone-lysine N-methyltransferase 2C
1057
Histone-lysine N-methyltransferase 2C
1060
3.8
66
0.4
Q8NEZ4Q8NEZ4['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']
Estrogen receptor
221
Estrogen receptor
227
6.9
61
0.24
P03372P03372['androgen metabolic process', 'antral ovarian follicle growth', 'cellular response to estradiol stimulus', 'cellular response to estrogen stimulus', 'chromatin remodeling', 'epithelial cell development', 'epithelial cell proliferation involved in mammary gland duct elongation', 'fibroblast proliferation', 'intracellular estrogen receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'male gonad development', 'mammary gland alveolus development', 'mammary gland branching involved in pregnancy', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of gene expression', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of miRNA maturation', 'negative regulation of transcription by RNA polymerase II', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of fibroblast proliferation', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of phospholipase C activity', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis', 'prostate epithelial cord elongation', 'protein localization to chromatin', 'regulation of branching involved in prostate gland morphogenesis', 'regulation of epithelial cell apoptotic process', 'regulation of inflammatory response', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to estradiol', 'response to estrogen', 'signal transduction', 'stem cell differentiation', 'transcription by RNA polymerase II', 'uterus development', 'vagina development']['androgen metabolic process', 'antral ovarian follicle growth', 'cellular response to estradiol stimulus', 'cellular response to estrogen stimulus', 'chromatin remodeling', 'epithelial cell development', 'epithelial cell proliferation involved in mammary gland duct elongation', 'fibroblast proliferation', 'intracellular estrogen receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'male gonad development', 'mammary gland alveolus development', 'mammary gland branching involved in pregnancy', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of gene expression', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of miRNA maturation', 'negative regulation of transcription by RNA polymerase II', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of fibroblast proliferation', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of phospholipase C activity', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis', 'prostate epithelial cord elongation', 'protein localization to chromatin', 'regulation of branching involved in prostate gland morphogenesis', 'regulation of epithelial cell apoptotic process', 'regulation of inflammatory response', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to estradiol', 'response to estrogen', 'signal transduction', 'stem cell differentiation', 'transcription by RNA polymerase II', 'uterus development', 'vagina development']
Copper homeostasis protein cutC homolog
248
Copper homeostasis protein cutC homolog
248
9.2
46
0.24
Q9NTM9Q9NTM9['copper ion homeostasis', 'copper ion transport', 'protein tetramerization']['copper ion homeostasis', 'copper ion transport', 'protein tetramerization']
Fibrinogen gamma chain
34
Fibrinogen gamma chain
34
3.3
43
0.7
P02679P02679['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Neutrophil defensin 1
83
Neutrophil defensin 1
68
6.9
76
0.19
P59665P59665['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']
Insulin
84
Insulin
31
2.0
58
0.84
A6XGL2A6XGL2['glucose metabolic process']['glucose metabolic process']
Dr1-associated corepressor
73
Protein Dr1
42
8.6
51
0.23
Q14919Q01658['negative regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'transcription by RNA polymerase II']['chromatin remodeling', 'histone H3 acetylation', 'histone H3-K14 acetylation', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase II', 'regulation of cell cycle', 'regulation of cell division', 'regulation of embryonic development', 'regulation of histone deacetylation', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'regulation of tubulin deacetylation', 'RNA polymerase II preinitiation complex assembly']
Potassium voltage-gated channel subfamily B member 1
133
Potassium voltage-gated channel subfamily B member 1
111
3.7
53
0.5
Q14721Q14721['action potential', 'cellular response to calcium ion', 'cellular response to glucose stimulus', 'cellular response to nutrient levels', 'clustering of voltage-gated potassium channels', 'glucose homeostasis', 'glutamate receptor signaling pathway', 'negative regulation of insulin secretion', 'positive regulation of calcium ion-dependent exocytosis', 'positive regulation of catecholamine secretion', 'positive regulation of long-term synaptic depression', 'positive regulation of norepinephrine secretion', 'positive regulation of protein targeting to membrane', 'potassium ion export across plasma membrane', 'potassium ion transmembrane transport', 'protein homooligomerization', 'protein localization to plasma membrane', 'regulation of action potential', 'regulation of ion transmembrane transport', 'regulation of motor neuron apoptotic process', 'response to axon injury', 'response to L-glutamate', 'vesicle docking involved in exocytosis']['action potential', 'cellular response to calcium ion', 'cellular response to glucose stimulus', 'cellular response to nutrient levels', 'clustering of voltage-gated potassium channels', 'glucose homeostasis', 'glutamate receptor signaling pathway', 'negative regulation of insulin secretion', 'positive regulation of calcium ion-dependent exocytosis', 'positive regulation of catecholamine secretion', 'positive regulation of long-term synaptic depression', 'positive regulation of norepinephrine secretion', 'positive regulation of protein targeting to membrane', 'potassium ion export across plasma membrane', 'potassium ion transmembrane transport', 'protein homooligomerization', 'protein localization to plasma membrane', 'regulation of action potential', 'regulation of ion transmembrane transport', 'regulation of motor neuron apoptotic process', 'response to axon injury', 'response to L-glutamate', 'vesicle docking involved in exocytosis']
Interleukin-1 receptor-associated kinase 3
287
Interleukin-1 receptor-associated kinase 3
202
2.0
50
0.98
Q9Y616Q9Y616['cytokine-mediated signaling pathway', 'interleukin-1-mediated signaling pathway', 'intracellular signal transduction', 'MyD88-dependent toll-like receptor signaling pathway', 'negative regulation of cytokine-mediated signaling pathway', 'negative regulation of innate immune response', 'negative regulation of interleukin-12 production', 'negative regulation of interleukin-6 production', 'negative regulation of macrophage cytokine production', 'negative regulation of MAP kinase activity', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of protein catabolic process', 'negative regulation of protein-containing complex disassembly', 'negative regulation of toll-like receptor signaling pathway', 'negative regulation of tumor necrosis factor production', 'positive regulation of cytokine production', 'positive regulation of macrophage tolerance induction', 'positive regulation of NF-kappaB transcription factor activity', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of protein-containing complex disassembly', 'response to exogenous dsRNA', 'response to interleukin-1', 'response to lipopolysaccharide', 'response to peptidoglycan', 'response to virus']['cytokine-mediated signaling pathway', 'interleukin-1-mediated signaling pathway', 'intracellular signal transduction', 'MyD88-dependent toll-like receptor signaling pathway', 'negative regulation of cytokine-mediated signaling pathway', 'negative regulation of innate immune response', 'negative regulation of interleukin-12 production', 'negative regulation of interleukin-6 production', 'negative regulation of macrophage cytokine production', 'negative regulation of MAP kinase activity', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of protein catabolic process', 'negative regulation of protein-containing complex disassembly', 'negative regulation of toll-like receptor signaling pathway', 'negative regulation of tumor necrosis factor production', 'positive regulation of cytokine production', 'positive regulation of macrophage tolerance induction', 'positive regulation of NF-kappaB transcription factor activity', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of protein-containing complex disassembly', 'response to exogenous dsRNA', 'response to interleukin-1', 'response to lipopolysaccharide', 'response to peptidoglycan', 'response to virus']
Glycoprotein hormones alpha chain
31
Follitropin subunit beta
50
6.9
59
0.25
Q96QJ4P01225[]['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Natural killer cells antigen CD94
59
NKG2-A/NKG2-B type II integral membrane protein
119
6.9
64
0.23
Q13241P26715['adaptive immune response', 'cell surface receptor signaling pathway', 'natural killer cell mediated immunity', 'negative regulation of natural killer cell mediated cytotoxicity', 'negative regulation of T cell mediated cytotoxicity', 'positive regulation of natural killer cell mediated cytotoxicity', 'regulation of natural killer cell activation', 'stimulatory C-type lectin receptor signaling pathway']['adaptive immune response', 'CD8-positive, gamma-delta intraepithelial T cell differentiation', 'cell surface receptor signaling pathway', 'innate immune response', 'natural killer cell inhibitory signaling pathway', 'negative regulation of natural killer cell mediated cytotoxicity', 'negative regulation of T cell mediated cytotoxicity', 'regulation of natural killer cell activation']
Defensin alpha 5
82
Defensin alpha 5
67
3.7
79
0.34
Q01523Q01523['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']
Membrane primary amine oxidase
41
Membrane primary amine oxidase
748
9.9
61
0.17
Q16853Q16853['amine metabolic process', 'cell adhesion', 'inflammatory response', 'negative regulation of primary amine oxidase activity', 'response to antibiotic']['amine metabolic process', 'cell adhesion', 'inflammatory response', 'negative regulation of primary amine oxidase activity', 'response to antibiotic']
F-box only protein 11
868
F-box only protein 11
899
3.7
55
0.5
Q86XK2Q86XK2['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']
Pancreatic trypsin inhibitor
40
Pancreatic trypsin inhibitor
90
2.0
60
0.82
P00974P00974['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Fibrinogen beta chain
106
Fibrinogen alpha chain
47
7.4
71
0.19
P02675P02671['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']
Hepatocyte growth factor
206
Hepatocyte growth factor
206
3.7
55
0.49
P14210P14210['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'mitotic cell cycle', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of autophagy', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'mitotic cell cycle', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of autophagy', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']
Fibrinogen alpha chain
68
Fibrinogen alpha chain
47
7.6
68
0.19
P02671P02671['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']
Potassium voltage-gated channel subfamily B member 1
132
Potassium voltage-gated channel subfamily B member 1
111
3.6
46
0.6
Q14721Q14721['action potential', 'cellular response to calcium ion', 'cellular response to glucose stimulus', 'cellular response to nutrient levels', 'clustering of voltage-gated potassium channels', 'glucose homeostasis', 'glutamate receptor signaling pathway', 'negative regulation of insulin secretion', 'positive regulation of calcium ion-dependent exocytosis', 'positive regulation of catecholamine secretion', 'positive regulation of long-term synaptic depression', 'positive regulation of norepinephrine secretion', 'positive regulation of protein targeting to membrane', 'potassium ion export across plasma membrane', 'potassium ion transmembrane transport', 'protein homooligomerization', 'protein localization to plasma membrane', 'regulation of action potential', 'regulation of ion transmembrane transport', 'regulation of motor neuron apoptotic process', 'response to axon injury', 'response to L-glutamate', 'vesicle docking involved in exocytosis']['action potential', 'cellular response to calcium ion', 'cellular response to glucose stimulus', 'cellular response to nutrient levels', 'clustering of voltage-gated potassium channels', 'glucose homeostasis', 'glutamate receptor signaling pathway', 'negative regulation of insulin secretion', 'positive regulation of calcium ion-dependent exocytosis', 'positive regulation of catecholamine secretion', 'positive regulation of long-term synaptic depression', 'positive regulation of norepinephrine secretion', 'positive regulation of protein targeting to membrane', 'potassium ion export across plasma membrane', 'potassium ion transmembrane transport', 'protein homooligomerization', 'protein localization to plasma membrane', 'regulation of action potential', 'regulation of ion transmembrane transport', 'regulation of motor neuron apoptotic process', 'response to axon injury', 'response to L-glutamate', 'vesicle docking involved in exocytosis']
Platelet basic protein
105
Platelet basic protein
65
9.3
68
0.16
P02775P02775['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'defense response to bacterium', 'glucose transmembrane transport', 'inflammatory response', 'killing of cells of another organism', 'neutrophil chemotaxis', 'positive regulation of cell division']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'defense response to bacterium', 'glucose transmembrane transport', 'inflammatory response', 'killing of cells of another organism', 'neutrophil chemotaxis', 'positive regulation of cell division']
Interleukin-17A
129
Interleukin-17F
47
2.0
36
1.37
Q16552Q96PD4['adaptive immune response', 'apoptotic process', 'cell death', 'cell-cell signaling', 'cellular response to interleukin-1', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'fibroblast activation', 'granulocyte migration', 'immune response', 'inflammatory response', 'innate immune response', 'interleukin-17-mediated signaling pathway', 'intestinal epithelial structure maintenance', 'Notch signaling pathway', 'positive regulation of antimicrobial peptide production', 'positive regulation of bicellular tight junction assembly', 'positive regulation of chemokine (C-X-C motif) ligand 1 production', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-16 production', 'positive regulation of interleukin-23 production', 'positive regulation of interleukin-6 production', 'positive regulation of osteoclast differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production']['adaptive immune response', 'cartilage development', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'inflammatory response', 'innate immune response', 'interleukin-17-mediated signaling pathway', 'negative regulation of angiogenesis', 'positive regulation of antimicrobial peptide production', 'positive regulation of chemokine (C-X-C motif) ligand 1 production', 'positive regulation of cytokine production', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of interleukin-6 production', 'positive regulation of lymphotoxin A production', 'positive regulation of transcription by RNA polymerase II', 'regulation of granulocyte macrophage colony-stimulating factor production', 'regulation of interleukin-2 production', 'regulation of interleukin-6 production', 'regulation of interleukin-8 production', 'regulation of transforming growth factor beta receptor signaling pathway']
Insulin-like growth factor-binding protein 4
174
Insulin-like growth factor I
96
7.7
70
0.19
P22692P05019['inflammatory response', 'MAPK cascade', 'negative regulation of canonical Wnt signaling pathway', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'regulation of cell growth', 'regulation of glucose metabolic process', 'regulation of insulin-like growth factor receptor signaling pathway', 'signal transduction', 'type B pancreatic cell proliferation']['activation of protein kinase B activity', 'bone mineralization involved in bone maturation', 'cell activation', 'cell population proliferation', 'cellular response to amyloid-beta', 'ERK1 and ERK2 cascade', 'glycolate metabolic process', 'insulin-like growth factor receptor signaling pathway', 'muscle hypertrophy', 'muscle organ development', 'myoblast differentiation', 'myoblast proliferation', 'myotube cell development', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of gene expression', 'negative regulation of interleukin-1 beta production', 'negative regulation of neuroinflammatory response', 'negative regulation of oocyte development', 'negative regulation of release of cytochrome c from mitochondria', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of tumor necrosis factor production', 'negative regulation of vascular associated smooth muscle cell apoptotic process', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol-mediated signaling', 'positive regulation of activated T cell proliferation', 'positive regulation of calcineurin-NFAT signaling cascade', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of DNA binding', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Ras protein signal transduction', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of trophectodermal cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase B signaling', 'protein stabilization', 'proteoglycan biosynthetic process', 'Ras protein signal transduction', 'regulation of gene expression', 'regulation of multicellular organism growth', 'regulation of protein phosphorylation', 'response to heat', 'signal transduction', 'skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration', 'skeletal system development', 'wound healing']
Lysosomal protective protein
281
Lysosomal protective protein
331
2.0
47
1.05
P10619P10619['intracellular protein transport', 'negative regulation of chaperone-mediated autophagy', 'proteolysis', 'regulation of chaperone-mediated autophagy', 'regulation of protein stability']['intracellular protein transport', 'negative regulation of chaperone-mediated autophagy', 'proteolysis', 'regulation of chaperone-mediated autophagy', 'regulation of protein stability']
Interleukin-17A
146
Interleukin-17A
146
7.4
92
0.15
Q16552Q16552['adaptive immune response', 'apoptotic process', 'cell death', 'cell-cell signaling', 'cellular response to interleukin-1', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'fibroblast activation', 'granulocyte migration', 'immune response', 'inflammatory response', 'innate immune response', 'interleukin-17-mediated signaling pathway', 'intestinal epithelial structure maintenance', 'Notch signaling pathway', 'positive regulation of antimicrobial peptide production', 'positive regulation of bicellular tight junction assembly', 'positive regulation of chemokine (C-X-C motif) ligand 1 production', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-16 production', 'positive regulation of interleukin-23 production', 'positive regulation of interleukin-6 production', 'positive regulation of osteoclast differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production']['adaptive immune response', 'apoptotic process', 'cell death', 'cell-cell signaling', 'cellular response to interleukin-1', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'fibroblast activation', 'granulocyte migration', 'immune response', 'inflammatory response', 'innate immune response', 'interleukin-17-mediated signaling pathway', 'intestinal epithelial structure maintenance', 'Notch signaling pathway', 'positive regulation of antimicrobial peptide production', 'positive regulation of bicellular tight junction assembly', 'positive regulation of chemokine (C-X-C motif) ligand 1 production', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-16 production', 'positive regulation of interleukin-23 production', 'positive regulation of interleukin-6 production', 'positive regulation of osteoclast differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production']
Glutamate receptor 2
330
Glutamate receptor 4
84
9.2
74
0.15
P19491P19493['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']['chemical synaptic transmission', 'modulation of chemical synaptic transmission', 'negative regulation of smooth muscle cell apoptotic process', 'positive regulation of synaptic transmission, glutamatergic', 'regulation of synapse structure or activity', 'response to fungicide']
Glycoprotein hormones alpha chain
31
Follitropin subunit beta
69
10.0
64
0.16
Q96QJ4P01225[]['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
C-type lectin domain family 4 member D
66
C-type lectin domain family 4 member D
66
3.5
83
0.35
Q8WXI8Q8WXI8['adaptive immune response', 'antifungal innate immune response', 'defense response to bacterium', 'Fc-gamma receptor signaling pathway', 'immune response', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of myeloid dendritic cell activation', 'T cell differentiation involved in immune response']['adaptive immune response', 'antifungal innate immune response', 'defense response to bacterium', 'Fc-gamma receptor signaling pathway', 'immune response', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of myeloid dendritic cell activation', 'T cell differentiation involved in immune response']
C4b-binding protein alpha chain
558
C4b-binding protein alpha chain
546
2.0
52
0.95
P04003P04003['complement activation, classical pathway', 'innate immune response', 'negative regulation of complement activation, classical pathway', 'positive regulation of protein catabolic process', 'regulation of opsonization', 'response to symbiotic bacterium']['complement activation, classical pathway', 'innate immune response', 'negative regulation of complement activation, classical pathway', 'positive regulation of protein catabolic process', 'regulation of opsonization', 'response to symbiotic bacterium']
Neutrophil defensin 1
93
Neutrophil defensin 1
68
8.9
72
0.16
P59665P59665['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']
Histone-lysine N-methyltransferase 2C
1078
Histone-lysine N-methyltransferase 2C
1057
8.9
69
0.16
Q8NEZ4Q8NEZ4['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']
Norrin
131
Norrin
95
4.5
74
0.3
Q00604Q00604['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']
S-phase kinase-associated protein 1
160
F-box/LRR-repeat protein 17
342
4.3
nan
nan
P63208Q9UF56['histone H2A monoubiquitination', 'maintenance of protein location in nucleus', 'positive regulation of ubiquitin protein ligase activity', 'protein K48-linked ubiquitination', 'protein polyubiquitination', 'protein ubiquitination', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process']['entrainment of circadian clock by photoperiod', 'G2/M transition of mitotic cell cycle', 'nervous system development', 'neural crest cell differentiation', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein polyubiquitination', 'protein quality control for misfolded or incompletely synthesized proteins', 'protein ubiquitination', 'regulation of cell cycle', 'regulation of smoothened signaling pathway', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process']
Glutamate receptor 2
330
Glutamate receptor 4
331
9.1
76
0.14
P19491P19493['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']['chemical synaptic transmission', 'modulation of chemical synaptic transmission', 'negative regulation of smooth muscle cell apoptotic process', 'positive regulation of synaptic transmission, glutamatergic', 'regulation of synapse structure or activity', 'response to fungicide']
Serine/threonine-protein kinase Chk1
57
Claspin
944
5.7
nan
nan
O14757Q9HAW4['apoptotic process', 'apoptotic process involved in development', 'cellular response to caffeine', 'cellular response to DNA damage stimulus', 'cellular response to mechanical stimulus', 'DNA damage checkpoint signaling', 'DNA damage induced protein phosphorylation', 'DNA repair', 'DNA replication', 'epigenetic maintenance of chromatin in transcription-competent conformation', 'G2/M transition of mitotic cell cycle', 'inner cell mass cell proliferation', 'intracellular signal transduction', 'mitotic G2 DNA damage checkpoint signaling', 'mitotic G2/M transition checkpoint', 'negative regulation of DNA biosynthetic process', 'negative regulation of G0 to G1 transition', 'negative regulation of mitotic nuclear division', 'nucleus organization', 'peptidyl-threonine phosphorylation', 'positive regulation of cell cycle', 'protein phosphorylation', 'regulation of cell population proliferation', 'regulation of double-strand break repair via homologous recombination', 'regulation of histone H3-K9 acetylation', 'regulation of mitotic centrosome separation', 'regulation of signal transduction by p53 class mediator', 'regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage', 'replicative senescence']['activation of protein kinase activity', 'DNA damage checkpoint signaling', 'DNA repair', 'DNA replication checkpoint signaling', 'mitotic DNA replication checkpoint signaling', 'mitotic G2 DNA damage checkpoint signaling', 'peptidyl-serine phosphorylation']
Urokinase-type plasminogen activator
168
Urokinase-type plasminogen activator
299
2.0
63
0.78
P00749P00749['blood coagulation', 'chemotaxis', 'fibrinolysis', 'negative regulation of fibrinolysis', 'negative regulation of plasminogen activation', 'plasminogen activation', 'positive regulation of cell migration', 'proteolysis', 'regulation of cell adhesion', 'regulation of cell adhesion mediated by integrin', 'regulation of cell population proliferation', 'regulation of fibrinolysis', 'regulation of plasminogen activation', 'regulation of signaling receptor activity', 'regulation of smooth muscle cell migration', 'regulation of smooth muscle cell-matrix adhesion', 'regulation of wound healing', 'response to hypoxia', 'signal transduction', 'smooth muscle cell migration', 'urokinase plasminogen activator signaling pathway']['blood coagulation', 'chemotaxis', 'fibrinolysis', 'negative regulation of fibrinolysis', 'negative regulation of plasminogen activation', 'plasminogen activation', 'positive regulation of cell migration', 'proteolysis', 'regulation of cell adhesion', 'regulation of cell adhesion mediated by integrin', 'regulation of cell population proliferation', 'regulation of fibrinolysis', 'regulation of plasminogen activation', 'regulation of signaling receptor activity', 'regulation of smooth muscle cell migration', 'regulation of smooth muscle cell-matrix adhesion', 'regulation of wound healing', 'response to hypoxia', 'signal transduction', 'smooth muscle cell migration', 'urokinase plasminogen activator signaling pathway']
Cytosolic iron-sulfur assembly component 2A
99
Cytosolic iron-sulfur assembly component 2A
155
4.0
71
0.35
Q9H5X1Q9H5X1['chromosome segregation', 'iron-sulfur cluster assembly', 'protein maturation by [4Fe-4S] cluster transfer', 'protein maturation by iron-sulfur cluster transfer']['chromosome segregation', 'iron-sulfur cluster assembly', 'protein maturation by [4Fe-4S] cluster transfer', 'protein maturation by iron-sulfur cluster transfer']
Hepatocyte growth factor
206
Hepatocyte growth factor
128
4.6
65
0.34
P14210P14210['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'mitotic cell cycle', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of autophagy', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'mitotic cell cycle', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of autophagy', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']
Peroxiredoxin-1
52
Peroxiredoxin-1
173
2.0
52
0.95
1
✔Q63716Q63716['cell population proliferation', 'cell redox homeostasis', 'erythrocyte homeostasis', 'hydrogen peroxide catabolic process', 'leukocyte activation', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'regulation of NIK/NF-kappaB signaling', 'regulation of stress-activated MAPK cascade', 'removal of superoxide radicals', 'response to oxidative stress', 'response to reactive oxygen species']['cell population proliferation', 'cell redox homeostasis', 'erythrocyte homeostasis', 'hydrogen peroxide catabolic process', 'leukocyte activation', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'regulation of NIK/NF-kappaB signaling', 'regulation of stress-activated MAPK cascade', 'removal of superoxide radicals', 'response to oxidative stress', 'response to reactive oxygen species']
Beta-hexosaminidase subunit beta
309
Beta-hexosaminidase subunit beta
360
2.0
51
0.96
P07686P07686['astrocyte cell migration', 'cellular calcium ion homeostasis', 'ganglioside catabolic process', 'glycosaminoglycan metabolic process', 'lipid storage', 'locomotory behavior', 'lysosome organization', 'maintenance of location in cell', 'male courtship behavior', 'myelination', 'neuromuscular process controlling balance', 'neuron cellular homeostasis', 'oligosaccharide catabolic process', 'oogenesis', 'penetration of zona pellucida', 'phospholipid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'protein metabolic process', 'regulation of cell shape', 'sensory perception of sound', 'single fertilization', 'skeletal system development']['astrocyte cell migration', 'cellular calcium ion homeostasis', 'ganglioside catabolic process', 'glycosaminoglycan metabolic process', 'lipid storage', 'locomotory behavior', 'lysosome organization', 'maintenance of location in cell', 'male courtship behavior', 'myelination', 'neuromuscular process controlling balance', 'neuron cellular homeostasis', 'oligosaccharide catabolic process', 'oogenesis', 'penetration of zona pellucida', 'phospholipid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'protein metabolic process', 'regulation of cell shape', 'sensory perception of sound', 'single fertilization', 'skeletal system development']
Neuroblastoma suppressor of tumorigenicity 1
123
Neuroblastoma suppressor of tumorigenicity 1
123
4.2
62
0.38
P41271P41271['animal organ morphogenesis', 'determination of dorsal identity', 'negative regulation of BMP signaling pathway', 'negative regulation of monocyte chemotaxis', 'nervous system development', 'neuron projection morphogenesis', 'positive regulation of neuron differentiation', 'sequestering of BMP from receptor via BMP binding', 'sequestering of BMP in extracellular matrix']['animal organ morphogenesis', 'determination of dorsal identity', 'negative regulation of BMP signaling pathway', 'negative regulation of monocyte chemotaxis', 'nervous system development', 'neuron projection morphogenesis', 'positive regulation of neuron differentiation', 'sequestering of BMP from receptor via BMP binding', 'sequestering of BMP in extracellular matrix']
Defensin alpha 5
67
Defensin alpha 5
67
4.2
84
0.28
Q01523Q01523['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']
Growth/differentiation factor 2
327
Growth/differentiation factor 2
392
9.0
74
0.15
Q9UK05Q9UK05['activin receptor signaling pathway', 'angiogenesis', 'blood vessel morphogenesis', 'BMP signaling pathway', 'branching involved in blood vessel morphogenesis', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'negative regulation of angiogenesis', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell growth', 'negative regulation of DNA biosynthetic process', 'negative regulation of DNA replication', 'negative regulation of endothelial cell migration', 'negative regulation of endothelial cell proliferation', 'ossification', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of angiogenesis', 'positive regulation of BMP signaling pathway', 'positive regulation of cartilage development', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of interleukin-8 production', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'SMAD protein signal transduction', 'transcription by RNA polymerase II', 'vasculogenesis']['activin receptor signaling pathway', 'angiogenesis', 'blood vessel morphogenesis', 'BMP signaling pathway', 'branching involved in blood vessel morphogenesis', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'negative regulation of angiogenesis', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell growth', 'negative regulation of DNA biosynthetic process', 'negative regulation of DNA replication', 'negative regulation of endothelial cell migration', 'negative regulation of endothelial cell proliferation', 'ossification', 'osteoblast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of angiogenesis', 'positive regulation of BMP signaling pathway', 'positive regulation of cartilage development', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of interleukin-8 production', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'SMAD protein signal transduction', 'transcription by RNA polymerase II', 'vasculogenesis']
C-C motif chemokine 18
30
C-C motif chemokine 18
30
9.0
72
0.15
P55774P55774['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell communication', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'signal transduction']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell communication', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'signal transduction']
Receptor-interacting serine/threonine-protein kinase 2
7
Receptor-interacting serine/threonine-protein kinase 2
7
5.0
50
0.4
O43353O43353['activation of cysteine-type endopeptidase activity', 'adaptive immune response', 'apoptotic process', 'CD4-positive, alpha-beta T cell proliferation', 'cellular response to lipoteichoic acid', 'cellular response to muramyl dipeptide', 'cellular response to peptidoglycan', 'cytokine-mediated signaling pathway', 'defense response to Gram-positive bacterium', 'ERK1 and ERK2 cascade', 'I-kappaB kinase/NF-kappaB signaling', 'immature T cell proliferation in thymus', 'inflammatory response', 'innate immune response', 'JNK cascade', 'lipopolysaccharide-mediated signaling pathway', 'nucleotide-binding oligomerization domain containing 1 signaling pathway', 'nucleotide-binding oligomerization domain containing 2 signaling pathway', 'positive regulation of apoptotic process', 'positive regulation of CD4-positive, alpha-beta T cell proliferation', 'positive regulation of cell death', 'positive regulation of chemokine production', 'positive regulation of cytokine-mediated signaling pathway', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of immature T cell proliferation in thymus', 'positive regulation of interferon-alpha production', 'positive regulation of interferon-beta production', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-2 production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of macrophage cytokine production', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein ubiquitination', 'positive regulation of T-helper 1 cell differentiation', 'positive regulation of T-helper 1 type immune response', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'positive regulation of xenophagy', 'response to exogenous dsRNA', 'response to interleukin-1', 'response to interleukin-12', 'response to interleukin-18', 'signal transduction', 'T cell receptor signaling pathway', 'toll-like receptor 2 signaling pathway', 'toll-like receptor 4 signaling pathway', 'xenophagy']['activation of cysteine-type endopeptidase activity', 'adaptive immune response', 'apoptotic process', 'CD4-positive, alpha-beta T cell proliferation', 'cellular response to lipoteichoic acid', 'cellular response to muramyl dipeptide', 'cellular response to peptidoglycan', 'cytokine-mediated signaling pathway', 'defense response to Gram-positive bacterium', 'ERK1 and ERK2 cascade', 'I-kappaB kinase/NF-kappaB signaling', 'immature T cell proliferation in thymus', 'inflammatory response', 'innate immune response', 'JNK cascade', 'lipopolysaccharide-mediated signaling pathway', 'nucleotide-binding oligomerization domain containing 1 signaling pathway', 'nucleotide-binding oligomerization domain containing 2 signaling pathway', 'positive regulation of apoptotic process', 'positive regulation of CD4-positive, alpha-beta T cell proliferation', 'positive regulation of cell death', 'positive regulation of chemokine production', 'positive regulation of cytokine-mediated signaling pathway', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of immature T cell proliferation in thymus', 'positive regulation of interferon-alpha production', 'positive regulation of interferon-beta production', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-2 production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of macrophage cytokine production', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein ubiquitination', 'positive regulation of T-helper 1 cell differentiation', 'positive regulation of T-helper 1 type immune response', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'positive regulation of xenophagy', 'response to exogenous dsRNA', 'response to interleukin-1', 'response to interleukin-12', 'response to interleukin-18', 'signal transduction', 'T cell receptor signaling pathway', 'toll-like receptor 2 signaling pathway', 'toll-like receptor 4 signaling pathway', 'xenophagy']
N6-adenosine-methyltransferase catalytic subunit
500
N6-adenosine-methyltransferase non-catalytic subunit
120
5.5
81
0.22
Q86U44Q9HCE5['adenosine to inosine editing', 'cellular response to DNA damage stimulus', 'cellular response to UV', 'circadian rhythm', 'dosage compensation by inactivation of X chromosome', 'endothelial to hematopoietic transition', 'forebrain radial glial cell differentiation', 'gliogenesis', 'innate immune response', 'mRNA catabolic process', 'mRNA destabilization', 'mRNA methylation', 'mRNA processing', 'mRNA splicing, via spliceosome', 'negative regulation of Notch signaling pathway', 'negative regulation of type I interferon-mediated signaling pathway', 'oogenesis', 'positive regulation of cap-independent translational initiation', 'positive regulation of translation', 'primary miRNA processing', 'regulation of hematopoietic stem cell differentiation', 'regulation of meiotic cell cycle', 'regulation of T cell differentiation', 'RNA methylation', 'spermatogenesis', 'stem cell population maintenance']['forebrain radial glial cell differentiation', 'gliogenesis', 'mRNA catabolic process', 'mRNA destabilization', 'mRNA methylation', 'mRNA splicing, via spliceosome', 'negative regulation of hematopoietic progenitor cell differentiation', 'positive regulation of translation', 'spermatogenesis', 'stem cell population maintenance']
Urokinase plasminogen activator surface receptor
98
Urokinase plasminogen activator surface receptor
25
5.5
60
0.3
Q03405Q03405['blood coagulation', 'chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'negative regulation of intrinsic apoptotic signaling pathway', 'positive regulation of DNA binding', 'positive regulation of epidermal growth factor receptor signaling pathway', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of protein phosphorylation', 'positive regulation of release of cytochrome c from mitochondria', 'regulation of cell adhesion', 'regulation of fibrinolysis', 'regulation of plasminogen activation', 'regulation of proteolysis', 'signal transduction', 'urokinase plasminogen activator signaling pathway']['blood coagulation', 'chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'negative regulation of intrinsic apoptotic signaling pathway', 'positive regulation of DNA binding', 'positive regulation of epidermal growth factor receptor signaling pathway', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of protein phosphorylation', 'positive regulation of release of cytochrome c from mitochondria', 'regulation of cell adhesion', 'regulation of fibrinolysis', 'regulation of plasminogen activation', 'regulation of proteolysis', 'signal transduction', 'urokinase plasminogen activator signaling pathway']
E3 ubiquitin-protein ligase XIAP
351
E3 ubiquitin-protein ligase XIAP
351
2.1
39
1.25
P98170P98170['cellular response to DNA damage stimulus', 'copper ion homeostasis', 'inhibition of cysteine-type endopeptidase activity', 'inhibition of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of tumor necrosis factor-mediated signaling pathway', 'neuron apoptotic process', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of JNK cascade', 'positive regulation of protein linear polyubiquitination', 'positive regulation of protein ubiquitination', 'regulation of apoptosis involved in tissue homeostasis', 'regulation of apoptotic process', 'regulation of BMP signaling pathway', 'regulation of cell cycle', 'regulation of cell population proliferation', 'regulation of inflammatory response', 'regulation of innate immune response', 'regulation of nucleotide-binding oligomerization domain containing signaling pathway', 'Wnt signaling pathway']['cellular response to DNA damage stimulus', 'copper ion homeostasis', 'inhibition of cysteine-type endopeptidase activity', 'inhibition of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of tumor necrosis factor-mediated signaling pathway', 'neuron apoptotic process', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of JNK cascade', 'positive regulation of protein linear polyubiquitination', 'positive regulation of protein ubiquitination', 'regulation of apoptosis involved in tissue homeostasis', 'regulation of apoptotic process', 'regulation of BMP signaling pathway', 'regulation of cell cycle', 'regulation of cell population proliferation', 'regulation of inflammatory response', 'regulation of innate immune response', 'regulation of nucleotide-binding oligomerization domain containing signaling pathway', 'Wnt signaling pathway']
TNF receptor-associated factor 3
533
Mitochondrial antiviral-signaling protein
140
2.0
72
0.68
Q60803Q8VCF0['apoptotic process', 'innate immune response', 'negative regulation of NF-kappaB transcription factor activity', 'positive regulation of JNK cascade', 'protein K63-linked ubiquitination', 'regulation of apoptotic process', 'regulation of cytokine production', 'regulation of defense response to virus', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of interferon-beta production', 'regulation of proteolysis', 'Toll signaling pathway', 'toll-like receptor signaling pathway', 'tumor necrosis factor-mediated signaling pathway']['activation of innate immune response', 'cellular response to exogenous dsRNA', 'defense response to bacterium', 'defense response to virus', 'innate immune response', 'negative regulation of viral genome replication', 'positive regulation of chemokine (C-C motif) ligand 5 production', 'positive regulation of defense response to virus by host', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of interferon-alpha production', 'positive regulation of interferon-beta production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of IP-10 production', 'positive regulation of myeloid dendritic cell cytokine production', 'positive regulation of protein import into nucleus', 'positive regulation of protein phosphorylation', 'positive regulation of response to cytokine stimulus', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'positive regulation of type I interferon production', 'positive regulation of type I interferon-mediated signaling pathway', 'regulation of peroxisome organization', 'RIG-I signaling pathway', 'signal transduction']
Serine/threonine-protein kinase 32A
340
Serine/threonine-protein kinase 32A
346
5.2
44
0.44
Q8WU08Q8WU08['intracellular signal transduction', 'peptidyl-serine phosphorylation']['intracellular signal transduction', 'peptidyl-serine phosphorylation']
Proteasome activator complex subunit 1
22
Proteasome activator complex subunit 2
5
2.0
nan
nan
P97371P97372['antigen processing and presentation of exogenous antigen', 'positive regulation of endopeptidase activity', 'regulation of G1/S transition of mitotic cell cycle', 'regulation of proteasomal protein catabolic process']['antigen processing and presentation of exogenous antigen', 'positive regulation of endopeptidase activity', 'regulation of G1/S transition of mitotic cell cycle', 'regulation of proteasomal protein catabolic process']
Glutamate receptor 2
330
Glutamate receptor 3
334
8.8
72
0.16
P19491P19492['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']['regulation of receptor recycling', 'response to fungicide', 'response to lithium ion']
C-type lectin domain family 2 member D
86
C-type lectin domain family 2 member D
75
9.9
81
0.12
Q9UHP7Q9UHP7['cell surface receptor signaling pathway']['cell surface receptor signaling pathway']
Defensin-6
99
Defensin-6
72
5.5
64
0.29
Q01524Q01524['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism']
Defensin alpha 5
92
Defensin alpha 5
67
9.1
nan
nan
Q01523Q01523['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']
Protein arginine N-methyltransferase 6
53
Protein arginine N-methyltransferase 6
232
2.0
50
0.99
Q6NZB1Q6NZB1['cellular senescence', 'chromatin organization', 'DNA repair', 'histone H3-R2 methylation', 'histone methylation', 'negative regulation of histone deacetylation', 'negative regulation of histone H3-K4 methylation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'peptidyl-arginine methylation, to asymmetrical-dimethyl arginine', 'peptidyl-arginine N-methylation', 'regulation of mitochondrion organization', 'regulation of signal transduction by p53 class mediator']['cellular senescence', 'chromatin organization', 'DNA repair', 'histone H3-R2 methylation', 'histone methylation', 'negative regulation of histone deacetylation', 'negative regulation of histone H3-K4 methylation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'peptidyl-arginine methylation, to asymmetrical-dimethyl arginine', 'peptidyl-arginine N-methylation', 'regulation of mitochondrion organization', 'regulation of signal transduction by p53 class mediator']
Glutamate receptor 2
330
Glutamate receptor 3
85
8.8
71
0.16
P19491P19492['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']['regulation of receptor recycling', 'response to fungicide', 'response to lithium ion']
Coagulation factor XI
500
Coagulation factor XI
380
2.0
54
0.91
P03951P03951['blood coagulation', 'blood coagulation, intrinsic pathway', 'plasminogen activation', 'positive regulation of fibrinolysis', 'proteolysis', 'zymogen activation']['blood coagulation', 'blood coagulation, intrinsic pathway', 'plasminogen activation', 'positive regulation of fibrinolysis', 'proteolysis', 'zymogen activation']
Secreted frizzled-related protein 3
35
Secreted frizzled-related protein 3
96
9.5
64
0.16
P97401P97401['canonical Wnt signaling pathway', 'cochlea morphogenesis', 'convergent extension involved in organogenesis', 'epithelial cell development', 'hepatocyte differentiation', 'inner ear morphogenesis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cartilage development', 'negative regulation of cell development', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of hepatocyte differentiation', 'negative regulation of Wnt signaling pathway', 'neural crest cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of fat cell differentiation', 'somite development']['canonical Wnt signaling pathway', 'cochlea morphogenesis', 'convergent extension involved in organogenesis', 'epithelial cell development', 'hepatocyte differentiation', 'inner ear morphogenesis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cartilage development', 'negative regulation of cell development', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of hepatocyte differentiation', 'negative regulation of Wnt signaling pathway', 'neural crest cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of fat cell differentiation', 'somite development']
Norrin
131
Norrin
93
6.0
68
0.25
Q00604Q00604['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']
NKG2-D type II integral membrane protein
96
NKG2-D type II integral membrane protein
105
5.9
76
0.22
P26718P26718['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of interferon-gamma production', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of nitric oxide biosynthetic process', 'signal transduction', 'stimulatory C-type lectin receptor signaling pathway', 'T cell costimulation']['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of interferon-gamma production', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of nitric oxide biosynthetic process', 'signal transduction', 'stimulatory C-type lectin receptor signaling pathway', 'T cell costimulation']
Chymotrypsinogen A
220
Serine protease inhibitor Kazal-type 1
39
9.1
80
0.14
P00766P00995['digestion', 'proteolysis']['cellular response to peptide hormone stimulus', 'negative regulation of calcium ion import', 'negative regulation of nitric oxide mediated signal transduction', 'negative regulation of peptidyl-tyrosine phosphorylation', 'negative regulation of serine-type endopeptidase activity', 'nitric oxide mediated signal transduction', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of epithelial cell proliferation', 'positive regulation of pancreatic juice secretion', 'positive regulation of peptide hormone secretion', 'regulation of acrosome reaction', 'regulation of store-operated calcium entry', 'response to ethanol', 'response to nutrient levels', 'sperm capacitation']
Proprotein convertase subtilisin/kexin type 9
375
Low-density lipoprotein receptor
318
8.8
61
0.19
Q8NBP7Q59FQ1['apoptotic process', 'cellular response to insulin stimulus', 'cellular response to starvation', 'cholesterol homeostasis', 'cholesterol metabolic process', 'kidney development', 'lipoprotein metabolic process', 'liver development', 'low-density lipoprotein particle receptor catabolic process', 'lysosomal transport', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of low-density lipoprotein particle receptor binding', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of receptor internalization', 'negative regulation of receptor recycling', 'negative regulation of receptor-mediated endocytosis involved in cholesterol transport', 'negative regulation of sodium ion transmembrane transporter activity', 'neurogenesis', 'neuron differentiation', 'phospholipid metabolic process', 'positive regulation of low-density lipoprotein particle receptor catabolic process', 'positive regulation of neuron apoptotic process', 'positive regulation of receptor internalization', 'protein autoprocessing', 'regulation of neuron apoptotic process', 'regulation of signaling receptor activity', 'triglyceride metabolic process']['amyloid-beta clearance', 'amyloid-beta clearance by cellular catabolic process', 'artery morphogenesis', 'cellular response to fatty acid', 'cellular response to low-density lipoprotein particle stimulus', 'cholesterol homeostasis', 'cholesterol import', 'cholesterol metabolic process', 'cholesterol transport', 'endocytosis', 'high-density lipoprotein particle clearance', 'intestinal cholesterol absorption', 'lipid metabolic process', 'lipoprotein catabolic process', 'long-term memory', 'low-density lipoprotein particle clearance', 'negative regulation of amyloid fibril formation', 'negative regulation of astrocyte activation', 'negative regulation of gene expression', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of microglial cell activation', 'negative regulation of protein metabolic process', 'negative regulation of receptor recycling', 'phagocytosis', 'phospholipid transport', 'plasma lipoprotein particle clearance', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of lysosomal protein catabolic process', 'positive regulation of triglyceride biosynthetic process', 'receptor-mediated endocytosis', 'receptor-mediated endocytosis involved in cholesterol transport', 'regulation of cholesterol metabolic process', 'regulation of phosphatidylcholine catabolic process', 'regulation of protein metabolic process', 'response to caloric restriction']
High affinity nerve growth factor receptor
579
High affinity nerve growth factor receptor
501
4.0
63
0.4
P04629P04629['aging', 'axon guidance', 'axonogenesis involved in innervation', 'B cell differentiation', 'behavioral response to formalin induced pain', 'cellular response to nerve growth factor stimulus', 'cellular response to nicotine', 'circadian rhythm', 'detection of mechanical stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in sensory perception of pain', 'learning or memory', 'mechanoreceptor differentiation', 'negative regulation of apoptotic process', 'negative regulation of cell population proliferation', 'negative regulation of neuron apoptotic process', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron development', 'neuron projection development', 'neurotrophin TRK receptor signaling pathway', 'olfactory nerve development', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of angiogenesis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of kinase activity', 'positive regulation of neuron projection development', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of programmed cell death', 'positive regulation of protein phosphorylation', 'positive regulation of Ras protein signal transduction', 'positive regulation of synapse assembly', 'positive regulation of synaptic transmission, glutamatergic', 'programmed cell death involved in cell development', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of protein kinase B signaling', 'response to axon injury', 'response to electrical stimulus', 'response to hydrostatic pressure', 'response to nutrient levels', 'response to radiation', 'response to xenobiotic stimulus', 'Sertoli cell development', 'sympathetic nervous system development', 'transmembrane receptor protein tyrosine kinase signaling pathway']['aging', 'axon guidance', 'axonogenesis involved in innervation', 'B cell differentiation', 'behavioral response to formalin induced pain', 'cellular response to nerve growth factor stimulus', 'cellular response to nicotine', 'circadian rhythm', 'detection of mechanical stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in sensory perception of pain', 'learning or memory', 'mechanoreceptor differentiation', 'negative regulation of apoptotic process', 'negative regulation of cell population proliferation', 'negative regulation of neuron apoptotic process', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron development', 'neuron projection development', 'neurotrophin TRK receptor signaling pathway', 'olfactory nerve development', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of angiogenesis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of kinase activity', 'positive regulation of neuron projection development', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of programmed cell death', 'positive regulation of protein phosphorylation', 'positive regulation of Ras protein signal transduction', 'positive regulation of synapse assembly', 'positive regulation of synaptic transmission, glutamatergic', 'programmed cell death involved in cell development', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of protein kinase B signaling', 'response to axon injury', 'response to electrical stimulus', 'response to hydrostatic pressure', 'response to nutrient levels', 'response to radiation', 'response to xenobiotic stimulus', 'Sertoli cell development', 'sympathetic nervous system development', 'transmembrane receptor protein tyrosine kinase signaling pathway']
S-phase kinase-associated protein 1
160
F-box only protein 4
80
9.1
nan
nan
P63208Q9UKT5['histone H2A monoubiquitination', 'maintenance of protein location in nucleus', 'positive regulation of ubiquitin protein ligase activity', 'protein K48-linked ubiquitination', 'protein polyubiquitination', 'protein ubiquitination', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process']['aging', 'cellular homeostasis', 'cellular response to ionizing radiation', 'common myeloid progenitor cell proliferation', 'negative regulation of fibroblast proliferation', 'negative regulation of protein localization to nucleus', 'positive regulation of protein polyubiquitination', 'positive regulation of protein ubiquitination', 'positive regulation of telomere maintenance via telomerase', 'post-transcriptional regulation of gene expression', 'protein destabilization', 'protein polyubiquitination', 'protein ubiquitination', 'regulation of DNA damage checkpoint', 'regulation of protein stability', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process', 'telomere maintenance', 'ubiquitin-dependent protein catabolic process']
Urokinase plasminogen activator surface receptor
25
Urokinase plasminogen activator surface receptor
93
6.9
64
0.23
Q03405Q03405['blood coagulation', 'chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'negative regulation of intrinsic apoptotic signaling pathway', 'positive regulation of DNA binding', 'positive regulation of epidermal growth factor receptor signaling pathway', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of protein phosphorylation', 'positive regulation of release of cytochrome c from mitochondria', 'regulation of cell adhesion', 'regulation of fibrinolysis', 'regulation of plasminogen activation', 'regulation of proteolysis', 'signal transduction', 'urokinase plasminogen activator signaling pathway']['blood coagulation', 'chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'negative regulation of intrinsic apoptotic signaling pathway', 'positive regulation of DNA binding', 'positive regulation of epidermal growth factor receptor signaling pathway', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of protein phosphorylation', 'positive regulation of release of cytochrome c from mitochondria', 'regulation of cell adhesion', 'regulation of fibrinolysis', 'regulation of plasminogen activation', 'regulation of proteolysis', 'signal transduction', 'urokinase plasminogen activator signaling pathway']
Defensin alpha 4
67
Defensin alpha 4
67
5.8
74
0.23
P12838P12838['antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'antimicrobial humoral response', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism', 'T cell chemotaxis']['antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'antimicrobial humoral response', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism', 'T cell chemotaxis']
F-BAR domain only protein 2
273
F-BAR domain only protein 2
147
2.0
48
1.02
Q96CF5Q96CF5['clathrin coat assembly', 'clathrin-dependent endocytosis', 'membrane invagination', 'protein localization to plasma membrane', 'synaptic vesicle endocytosis']['clathrin coat assembly', 'clathrin-dependent endocytosis', 'membrane invagination', 'protein localization to plasma membrane', 'synaptic vesicle endocytosis']
Defensin alpha 5
67
Defensin alpha 5
65
6.4
74
0.21
Q01523Q01523['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']
NKG2-D type II integral membrane protein
96
NKG2-D type II integral membrane protein
96
6.5
74
0.21
P26718P26718['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of interferon-gamma production', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of nitric oxide biosynthetic process', 'signal transduction', 'stimulatory C-type lectin receptor signaling pathway', 'T cell costimulation']['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of interferon-gamma production', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of nitric oxide biosynthetic process', 'signal transduction', 'stimulatory C-type lectin receptor signaling pathway', 'T cell costimulation']
B-cell lymphoma 6 protein
8
B-cell lymphoma 6 protein
8
6.9
67
0.22
P41182P41182['actin cytoskeleton organization', 'B cell proliferation', 'cell morphogenesis', 'cell-matrix adhesion', 'cellular response to DNA damage stimulus', 'erythrocyte development', 'germinal center formation', 'histone deacetylation', 'inflammatory response', 'isotype switching to IgE isotypes', 'negative regulation of B cell apoptotic process', 'negative regulation of cell growth', 'negative regulation of cell-matrix adhesion', 'negative regulation of cellular senescence', 'negative regulation of isotype switching to IgE isotypes', 'negative regulation of leukocyte proliferation', 'negative regulation of mast cell cytokine production', 'negative regulation of mitotic cell cycle DNA replication', 'negative regulation of Notch signaling pathway', 'negative regulation of plasma cell differentiation', 'negative regulation of Rho protein signal transduction', 'negative regulation of T-helper 2 cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'plasma cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of B cell proliferation', 'positive regulation of histone deacetylation', 'positive regulation of neuron differentiation', 'positive regulation of regulatory T cell differentiation', 'protein localization', 'pyramidal neuron differentiation', 'regulation of cell differentiation', 'regulation of cell population proliferation', 'regulation of cytokine production', 'regulation of germinal center formation', 'regulation of GTPase activity', 'regulation of immune response', 'regulation of immune system process', 'regulation of inflammatory response', 'regulation of memory T cell differentiation', 'regulation of T cell proliferation', 'regulation of transcription by RNA polymerase II', 'Rho protein signal transduction', 'spermatogenesis', 'T-helper 2 cell differentiation', 'transcription by RNA polymerase II', 'type 2 immune response']['actin cytoskeleton organization', 'B cell proliferation', 'cell morphogenesis', 'cell-matrix adhesion', 'cellular response to DNA damage stimulus', 'erythrocyte development', 'germinal center formation', 'histone deacetylation', 'inflammatory response', 'isotype switching to IgE isotypes', 'negative regulation of B cell apoptotic process', 'negative regulation of cell growth', 'negative regulation of cell-matrix adhesion', 'negative regulation of cellular senescence', 'negative regulation of isotype switching to IgE isotypes', 'negative regulation of leukocyte proliferation', 'negative regulation of mast cell cytokine production', 'negative regulation of mitotic cell cycle DNA replication', 'negative regulation of Notch signaling pathway', 'negative regulation of plasma cell differentiation', 'negative regulation of Rho protein signal transduction', 'negative regulation of T-helper 2 cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'plasma cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of B cell proliferation', 'positive regulation of histone deacetylation', 'positive regulation of neuron differentiation', 'positive regulation of regulatory T cell differentiation', 'protein localization', 'pyramidal neuron differentiation', 'regulation of cell differentiation', 'regulation of cell population proliferation', 'regulation of cytokine production', 'regulation of germinal center formation', 'regulation of GTPase activity', 'regulation of immune response', 'regulation of immune system process', 'regulation of inflammatory response', 'regulation of memory T cell differentiation', 'regulation of T cell proliferation', 'regulation of transcription by RNA polymerase II', 'Rho protein signal transduction', 'spermatogenesis', 'T-helper 2 cell differentiation', 'transcription by RNA polymerase II', 'type 2 immune response']
DNA repair protein RAD52 homolog
208
DNA repair protein RAD52 homolog
29
8.6
59
0.2
P43351P43351['cellular response to DNA damage stimulus', 'cellular response to oxidative stress', 'DNA double-strand break processing involved in repair via single-strand annealing', 'DNA recombinase assembly', 'DNA recombination', 'double-strand break repair', 'double-strand break repair via homologous recombination', 'double-strand break repair via single-strand annealing', 'mitotic recombination', 'regulation of nucleotide-excision repair']['cellular response to DNA damage stimulus', 'cellular response to oxidative stress', 'DNA double-strand break processing involved in repair via single-strand annealing', 'DNA recombinase assembly', 'DNA recombination', 'double-strand break repair', 'double-strand break repair via homologous recombination', 'double-strand break repair via single-strand annealing', 'mitotic recombination', 'regulation of nucleotide-excision repair']
Transcription initiation factor IIA subunit 1
337
Transcription initiation factor IIA subunit 2
98
8.6
72
0.16
P52655P52657['positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription initiation from RNA polymerase II promoter', 'RNA polymerase II preinitiation complex assembly', 'transcription by RNA polymerase II']['positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription initiation from RNA polymerase II promoter', 'RNA polymerase II preinitiation complex assembly', 'transcription by RNA polymerase II', 'transcription initiation from RNA polymerase II promoter']
DNA repair protein RAD52 homolog
25
DNA repair protein RAD52 homolog
29
9.5
62
0.17
P43351P43351['cellular response to DNA damage stimulus', 'cellular response to oxidative stress', 'DNA double-strand break processing involved in repair via single-strand annealing', 'DNA recombinase assembly', 'DNA recombination', 'double-strand break repair', 'double-strand break repair via homologous recombination', 'double-strand break repair via single-strand annealing', 'mitotic recombination', 'regulation of nucleotide-excision repair']['cellular response to DNA damage stimulus', 'cellular response to oxidative stress', 'DNA double-strand break processing involved in repair via single-strand annealing', 'DNA recombinase assembly', 'DNA recombination', 'double-strand break repair', 'double-strand break repair via homologous recombination', 'double-strand break repair via single-strand annealing', 'mitotic recombination', 'regulation of nucleotide-excision repair']
Toll-like receptor 2
750
Toll-like receptor 2
640
2.0
54
0.91
O60603O60603['apoptotic process', 'cell activation', 'cellular response to bacterial lipopeptide', 'cellular response to diacyl bacterial lipopeptide', 'cellular response to interferon-gamma', 'cellular response to lipoteichoic acid', 'cellular response to triacyl bacterial lipopeptide', 'central nervous system myelin formation', 'defense response to Gram-positive bacterium', 'defense response to virus', 'detection of diacyl bacterial lipopeptide', 'detection of triacyl bacterial lipopeptide', 'I-kappaB phosphorylation', 'immune response', 'inflammatory response', 'innate immune response', 'learning', 'leukotriene metabolic process', 'microglia development', 'microglial cell activation', 'MyD88-dependent toll-like receptor signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of phagocytosis', 'negative regulation of synapse assembly', 'nitric oxide metabolic process', 'positive regulation of cellular response to macrophage colony-stimulating factor stimulus', 'positive regulation of chemokine production', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of interferon-beta production', 'positive regulation of interleukin-10 production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-18 production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of matrix metallopeptidase secretion', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric-oxide synthase biosynthetic process', 'positive regulation of oligodendrocyte differentiation', 'positive regulation of toll-like receptor signaling pathway', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'positive regulation of Wnt signaling pathway', 'response to fatty acid', 'response to hypoxia', 'response to insulin', 'response to progesterone', 'response to toxic substance', 'signal transduction', 'toll-like receptor 2 signaling pathway', 'toll-like receptor signaling pathway', 'toll-like receptor TLR6']['apoptotic process', 'cell activation', 'cellular response to bacterial lipopeptide', 'cellular response to diacyl bacterial lipopeptide', 'cellular response to interferon-gamma', 'cellular response to lipoteichoic acid', 'cellular response to triacyl bacterial lipopeptide', 'central nervous system myelin formation', 'defense response to Gram-positive bacterium', 'defense response to virus', 'detection of diacyl bacterial lipopeptide', 'detection of triacyl bacterial lipopeptide', 'I-kappaB phosphorylation', 'immune response', 'inflammatory response', 'innate immune response', 'learning', 'leukotriene metabolic process', 'microglia development', 'microglial cell activation', 'MyD88-dependent toll-like receptor signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of phagocytosis', 'negative regulation of synapse assembly', 'nitric oxide metabolic process', 'positive regulation of cellular response to macrophage colony-stimulating factor stimulus', 'positive regulation of chemokine production', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of interferon-beta production', 'positive regulation of interleukin-10 production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-18 production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of matrix metallopeptidase secretion', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric-oxide synthase biosynthetic process', 'positive regulation of oligodendrocyte differentiation', 'positive regulation of toll-like receptor signaling pathway', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'positive regulation of Wnt signaling pathway', 'response to fatty acid', 'response to hypoxia', 'response to insulin', 'response to progesterone', 'response to toxic substance', 'signal transduction', 'toll-like receptor 2 signaling pathway', 'toll-like receptor signaling pathway', 'toll-like receptor TLR6']
Neuronal calcium sensor 1
38
Neuronal calcium sensor 1
38
6.4
63
0.25
P62168P62168['phosphatidylinositol-mediated signaling', 'positive regulation of exocytosis', 'regulation of neuron projection development', 'regulation of synaptic vesicle exocytosis']['phosphatidylinositol-mediated signaling', 'positive regulation of exocytosis', 'regulation of neuron projection development', 'regulation of synaptic vesicle exocytosis']
Protein MEMO1
7
Protein MEMO1
7
6.4
50
0.31
Q9Y316Q9Y316['regulation of microtubule-based process']['regulation of microtubule-based process']
Neutrophil defensin 1
68
Neutrophil defensin 1
68
4.6
73
0.3
P59665P59665['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']
Natural killer cells antigen CD94
58
NKG2-A/NKG2-B type II integral membrane protein
116
5.8
51
0.34
Q13241P26715['adaptive immune response', 'cell surface receptor signaling pathway', 'natural killer cell mediated immunity', 'negative regulation of natural killer cell mediated cytotoxicity', 'negative regulation of T cell mediated cytotoxicity', 'positive regulation of natural killer cell mediated cytotoxicity', 'regulation of natural killer cell activation', 'stimulatory C-type lectin receptor signaling pathway']['adaptive immune response', 'CD8-positive, gamma-delta intraepithelial T cell differentiation', 'cell surface receptor signaling pathway', 'innate immune response', 'natural killer cell inhibitory signaling pathway', 'negative regulation of natural killer cell mediated cytotoxicity', 'negative regulation of T cell mediated cytotoxicity', 'regulation of natural killer cell activation']
Cartilage oligomeric matrix protein
68
Cartilage oligomeric matrix protein
68
5.8
51
0.34
Q9R0G6Q9R0G6['apoptotic process', 'artery morphogenesis', 'blood coagulation', 'BMP signaling pathway', 'bone growth', 'bone mineralization', 'bone morphogenesis', 'cartilage development', 'cartilage homeostasis', 'chondrocyte development', 'chondrocyte proliferation', 'collagen fibril organization', 'endochondral bone growth', 'growth plate cartilage development', 'limb development', 'multicellular organism aging', 'multicellular organism growth', 'muscle cell development', 'musculoskeletal movement', 'negative regulation of apoptotic process', 'negative regulation of hemostasis', 'neuromuscular process', 'ossification', 'platelet aggregation', 'positive regulation of chondrocyte proliferation', 'protein homooligomerization', 'protein processing', 'protein secretion', 'regulation of bone mineralization', 'regulation of gene expression', 'response to unfolded protein', 'skeletal system development', 'skin development', 'tendon development', 'vascular associated smooth muscle cell development', 'vascular associated smooth muscle contraction']['apoptotic process', 'artery morphogenesis', 'blood coagulation', 'BMP signaling pathway', 'bone growth', 'bone mineralization', 'bone morphogenesis', 'cartilage development', 'cartilage homeostasis', 'chondrocyte development', 'chondrocyte proliferation', 'collagen fibril organization', 'endochondral bone growth', 'growth plate cartilage development', 'limb development', 'multicellular organism aging', 'multicellular organism growth', 'muscle cell development', 'musculoskeletal movement', 'negative regulation of apoptotic process', 'negative regulation of hemostasis', 'neuromuscular process', 'ossification', 'platelet aggregation', 'positive regulation of chondrocyte proliferation', 'protein homooligomerization', 'protein processing', 'protein secretion', 'regulation of bone mineralization', 'regulation of gene expression', 'response to unfolded protein', 'skeletal system development', 'skin development', 'tendon development', 'vascular associated smooth muscle cell development', 'vascular associated smooth muscle contraction']
Insulin
83
Insulin
31
7.6
63
0.21
A6XGL2A6XGL2['glucose metabolic process']['glucose metabolic process']
Pancreatic trypsin inhibitor
49
Pancreatic trypsin inhibitor
73
2.0
79
0.62
P00974P00974['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Neutrophil defensin 1
94
Neutrophil defensin 1
66
9.9
nan
nan
P59665P59665['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']
Chymotrypsinogen A
1
Chymotrypsinogen A
122
2.0
nan
nan
P00766P00766['digestion', 'proteolysis']['digestion', 'proteolysis']
Neutrophil defensin 3
68
Neutrophil defensin 3
83
5.9
70
0.24
P59666P59666['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to virus', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing of cells of another organism', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to virus', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing of cells of another organism', 'membrane disruption in another organism']
E3 ubiquitin-protein ligase SMURF2
716
Polyubiquitin-B
229
2.0
nan
nan
Q9HAU4P0CG47['negative regulation of BMP signaling pathway', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of trophoblast cell migration', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein polyubiquitination', 'protein ubiquitination', 'regulation of transforming growth factor beta receptor signaling pathway', 'ubiquitin-dependent protein catabolic process', 'ubiquitin-dependent SMAD protein catabolic process', 'Wnt signaling pathway, planar cell polarity pathway']['energy homeostasis', 'fat pad development', 'female gonad development', 'female meiosis I', 'hypothalamus gonadotrophin-releasing hormone neuron development', 'male meiosis I', 'mitochondrion transport along microtubule', 'modification-dependent protein catabolic process', 'neuron projection morphogenesis', 'positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'positive regulation of protein monoubiquitination', 'positive regulation of protein ubiquitination', 'protein ubiquitination', 'regulation of mitochondrial membrane potential', 'regulation of neuron death', 'regulation of proteasomal protein catabolic process', 'seminiferous tubule development']
Transforming growth factor beta-1 proprotein
225
Transforming growth factor beta-1 proprotein
225
8.8
nan
nan
P01137P01137['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']
NKG2-D type II integral membrane protein
112
NKG2-D type II integral membrane protein
112
6.4
76
0.2
O54709O54709['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of apoptotic process', 'positive regulation of interferon-gamma production', 'positive regulation of myeloid dendritic cell activation', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target', 'positive regulation of nitric oxide biosynthetic process', 'stimulatory C-type lectin receptor signaling pathway']['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of apoptotic process', 'positive regulation of interferon-gamma production', 'positive regulation of myeloid dendritic cell activation', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target', 'positive regulation of nitric oxide biosynthetic process', 'stimulatory C-type lectin receptor signaling pathway']
Insulin-like growth factor-binding protein 4
174
Insulin-like growth factor I
54
6.1
78
0.21
P22692P05019['inflammatory response', 'MAPK cascade', 'negative regulation of canonical Wnt signaling pathway', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'regulation of cell growth', 'regulation of glucose metabolic process', 'regulation of insulin-like growth factor receptor signaling pathway', 'signal transduction', 'type B pancreatic cell proliferation']['activation of protein kinase B activity', 'bone mineralization involved in bone maturation', 'cell activation', 'cell population proliferation', 'cellular response to amyloid-beta', 'ERK1 and ERK2 cascade', 'glycolate metabolic process', 'insulin-like growth factor receptor signaling pathway', 'muscle hypertrophy', 'muscle organ development', 'myoblast differentiation', 'myoblast proliferation', 'myotube cell development', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of gene expression', 'negative regulation of interleukin-1 beta production', 'negative regulation of neuroinflammatory response', 'negative regulation of oocyte development', 'negative regulation of release of cytochrome c from mitochondria', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of tumor necrosis factor production', 'negative regulation of vascular associated smooth muscle cell apoptotic process', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol-mediated signaling', 'positive regulation of activated T cell proliferation', 'positive regulation of calcineurin-NFAT signaling cascade', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of DNA binding', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Ras protein signal transduction', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of trophectodermal cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase B signaling', 'protein stabilization', 'proteoglycan biosynthetic process', 'Ras protein signal transduction', 'regulation of gene expression', 'regulation of multicellular organism growth', 'regulation of protein phosphorylation', 'response to heat', 'signal transduction', 'skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration', 'skeletal system development', 'wound healing']
Low affinity immunoglobulin epsilon Fc receptor
288
Low affinity immunoglobulin epsilon Fc receptor
288
7.1
45
0.31
P06734P06734['positive regulation of humoral immune response mediated by circulating immunoglobulin', 'positive regulation of killing of cells of another organism', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of nitric-oxide synthase biosynthetic process']['positive regulation of humoral immune response mediated by circulating immunoglobulin', 'positive regulation of killing of cells of another organism', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of nitric-oxide synthase biosynthetic process']
PRSS3 protein
68
Amyloid beta precursor like protein 2
319
8.5
88
0.13
Q8N2U3Q06481['proteolysis']['axonogenesis', 'central nervous system development', 'G protein-coupled receptor signaling pathway', 'regulation of cellular protein metabolic process']
Neutrophil defensin 1
73
Neutrophil defensin 1
66
9.9
61
0.17
P59665P59665['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']
Hepatocyte growth factor
129
Hepatocyte growth factor
289
9.9
80
0.13
Q08048Q08048['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'proteolysis', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'proteolysis', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']
Glycoprotein hormones alpha chain
31
Follitropin subunit beta
50
6.8
54
0.27
P01215P01225['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Protein-arginine deiminase type-3
564
Protein-arginine deiminase type-3
125
9.9
39
0.26
Q9ULW8Q9ULW8['histone citrullination']['histone citrullination']
Insulin-like growth factor I
54
Insulin-like growth factor-binding protein 1
176
6.8
80
0.19
P05019P08833['activation of protein kinase B activity', 'bone mineralization involved in bone maturation', 'cell activation', 'cell population proliferation', 'cellular response to amyloid-beta', 'ERK1 and ERK2 cascade', 'glycolate metabolic process', 'insulin-like growth factor receptor signaling pathway', 'muscle hypertrophy', 'muscle organ development', 'myoblast differentiation', 'myoblast proliferation', 'myotube cell development', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of gene expression', 'negative regulation of interleukin-1 beta production', 'negative regulation of neuroinflammatory response', 'negative regulation of oocyte development', 'negative regulation of release of cytochrome c from mitochondria', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of tumor necrosis factor production', 'negative regulation of vascular associated smooth muscle cell apoptotic process', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol-mediated signaling', 'positive regulation of activated T cell proliferation', 'positive regulation of calcineurin-NFAT signaling cascade', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of DNA binding', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Ras protein signal transduction', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of trophectodermal cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase B signaling', 'protein stabilization', 'proteoglycan biosynthetic process', 'Ras protein signal transduction', 'regulation of gene expression', 'regulation of multicellular organism growth', 'regulation of protein phosphorylation', 'response to heat', 'signal transduction', 'skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration', 'skeletal system development', 'wound healing']['aging', 'insulin receptor signaling pathway', 'negative regulation of canonical Wnt signaling pathway', 'positive regulation of cell growth', 'regulation of insulin-like growth factor receptor signaling pathway', 'signal transduction', 'tissue regeneration']
Glycoprotein hormones alpha chain
31
Follitropin subunit beta
102
6.7
52
0.29
P01215P01225['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Ubiquitin-like modifier-activating enzyme 5
250
Ubiquitin-like modifier-activating enzyme 5
95
8.6
nan
nan
Q9GZZ9Q9GZZ9['erythrocyte differentiation', 'megakaryocyte differentiation', 'neuromuscular process', 'protein K69-linked ufmylation', 'protein modification by small protein conjugation', 'protein ufmylation', 'regulation of intracellular estrogen receptor signaling pathway', 'response to endoplasmic reticulum stress', 'reticulophagy']['erythrocyte differentiation', 'megakaryocyte differentiation', 'neuromuscular process', 'protein K69-linked ufmylation', 'protein modification by small protein conjugation', 'protein ufmylation', 'regulation of intracellular estrogen receptor signaling pathway', 'response to endoplasmic reticulum stress', 'reticulophagy']
Immunoglobulin heavy constant gamma 1
103
Immunoglobulin kappa constant
107
2.0
nan
nan
P01857P01834['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'retina homeostasis']
Neuropilin-1
424
Neuropilin-1
424
9.6
68
0.15
O14786O14786['actin cytoskeleton reorganization', 'angiogenesis', 'angiogenesis involved in coronary vascular morphogenesis', 'animal organ morphogenesis', 'artery morphogenesis', 'axon extension involved in axon guidance', 'axon guidance', 'axonal fasciculation', 'axonogenesis involved in innervation', 'basal dendrite arborization', 'basal dendrite development', 'branching involved in blood vessel morphogenesis', 'branchiomotor neuron axon guidance', 'cell migration involved in sprouting angiogenesis', 'cell-cell signaling', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to vascular endothelial growth factor stimulus', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'dichotomous subdivision of terminal units involved in salivary gland branching', 'dorsal root ganglion morphogenesis', 'endothelial cell chemotaxis', 'endothelial cell migration', 'endothelial tip cell fate specification', 'facial nerve structural organization', 'facioacoustic ganglion development', 'gonadotrophin-releasing hormone neuronal migration to the hypothalamus', 'hepatocyte growth factor receptor signaling pathway', 'integrin-mediated signaling pathway', 'motor neuron migration', 'negative regulation of axon extension involved in axon guidance', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of neuron apoptotic process', 'nerve development', 'neural crest cell migration', 'neural crest cell migration involved in autonomic nervous system development', 'neuron migration', 'neuropilin signaling pathway', 'otic placode development', 'outflow tract septum morphogenesis', 'platelet-derived growth factor receptor signaling pathway', 'positive chemotaxis', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cytokine activity', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of filopodium assembly', 'positive regulation of focal adhesion assembly', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of smooth muscle cell migration', 'positive regulation of stress fiber assembly', 'positive regulation of substrate adhesion-dependent cell spreading', 'postsynapse organization', 'protein localization to early endosome', 'regulation of Cdc42 protein signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of vesicle-mediated transport', 'renal artery morphogenesis', 'response to wounding', 'retina vasculature morphogenesis in camera-type eye', 'retinal ganglion cell axon guidance', 'semaphorin-plexin signaling pathway', 'semaphorin-plexin signaling pathway involved in axon guidance', 'semaphorin-plexin signaling pathway involved in neuron projection guidance', 'sensory neuron axon guidance', 'signal transduction', 'sprouting angiogenesis', 'substrate adhesion-dependent cell spreading', 'substrate-dependent cell migration, cell extension', 'sympathetic ganglion development', 'sympathetic neuron projection extension', 'sympathetic neuron projection guidance', 'toxin transport', 'trigeminal ganglion development', 'trigeminal nerve structural organization', 'vascular endothelial growth factor receptor signaling pathway', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway', 'VEGF-activated neuropilin signaling pathway involved in axon guidance', 'ventral trunk neural crest cell migration', 'vestibulocochlear nerve structural organization', 'viral entry into host cell']['actin cytoskeleton reorganization', 'angiogenesis', 'angiogenesis involved in coronary vascular morphogenesis', 'animal organ morphogenesis', 'artery morphogenesis', 'axon extension involved in axon guidance', 'axon guidance', 'axonal fasciculation', 'axonogenesis involved in innervation', 'basal dendrite arborization', 'basal dendrite development', 'branching involved in blood vessel morphogenesis', 'branchiomotor neuron axon guidance', 'cell migration involved in sprouting angiogenesis', 'cell-cell signaling', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to vascular endothelial growth factor stimulus', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'dichotomous subdivision of terminal units involved in salivary gland branching', 'dorsal root ganglion morphogenesis', 'endothelial cell chemotaxis', 'endothelial cell migration', 'endothelial tip cell fate specification', 'facial nerve structural organization', 'facioacoustic ganglion development', 'gonadotrophin-releasing hormone neuronal migration to the hypothalamus', 'hepatocyte growth factor receptor signaling pathway', 'integrin-mediated signaling pathway', 'motor neuron migration', 'negative regulation of axon extension involved in axon guidance', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of neuron apoptotic process', 'nerve development', 'neural crest cell migration', 'neural crest cell migration involved in autonomic nervous system development', 'neuron migration', 'neuropilin signaling pathway', 'otic placode development', 'outflow tract septum morphogenesis', 'platelet-derived growth factor receptor signaling pathway', 'positive chemotaxis', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cytokine activity', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of filopodium assembly', 'positive regulation of focal adhesion assembly', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of smooth muscle cell migration', 'positive regulation of stress fiber assembly', 'positive regulation of substrate adhesion-dependent cell spreading', 'postsynapse organization', 'protein localization to early endosome', 'regulation of Cdc42 protein signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of vesicle-mediated transport', 'renal artery morphogenesis', 'response to wounding', 'retina vasculature morphogenesis in camera-type eye', 'retinal ganglion cell axon guidance', 'semaphorin-plexin signaling pathway', 'semaphorin-plexin signaling pathway involved in axon guidance', 'semaphorin-plexin signaling pathway involved in neuron projection guidance', 'sensory neuron axon guidance', 'signal transduction', 'sprouting angiogenesis', 'substrate adhesion-dependent cell spreading', 'substrate-dependent cell migration, cell extension', 'sympathetic ganglion development', 'sympathetic neuron projection extension', 'sympathetic neuron projection guidance', 'toxin transport', 'trigeminal ganglion development', 'trigeminal nerve structural organization', 'vascular endothelial growth factor receptor signaling pathway', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway', 'VEGF-activated neuropilin signaling pathway involved in axon guidance', 'ventral trunk neural crest cell migration', 'vestibulocochlear nerve structural organization', 'viral entry into host cell']
Kinesin-like protein KIF20A
606
Kinesin-like protein KIF20A
606
2.0
47
1.04
P97329P97329['microtubule bundle formation', 'microtubule-based movement', 'midbody abscission', 'mitotic cytokinesis', 'protein transport', 'regulation of cytokinesis']['microtubule bundle formation', 'microtubule-based movement', 'midbody abscission', 'mitotic cytokinesis', 'protein transport', 'regulation of cytokinesis']
Bone marrow stromal antigen 2
53
Bone marrow stromal antigen 2
53
9.5
24
0.44
Q10589Q10589['B cell activation', 'defense response to virus', 'innate immune response', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of intracellular transport of viral material', 'negative regulation of plasmacytoid dendritic cell cytokine production', 'negative regulation of viral genome replication', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of leukocyte proliferation', 'regulation of actin cytoskeleton organization', 'response to interferon-alpha', 'response to interferon-beta', 'response to interferon-gamma', 'response to virus']['B cell activation', 'defense response to virus', 'innate immune response', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of intracellular transport of viral material', 'negative regulation of plasmacytoid dendritic cell cytokine production', 'negative regulation of viral genome replication', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of leukocyte proliferation', 'regulation of actin cytoskeleton organization', 'response to interferon-alpha', 'response to interferon-beta', 'response to interferon-gamma', 'response to virus']
Tissue-type plasminogen activator
299
Tissue-type plasminogen activator
430
2.0
62
0.79
P00750P00750['blood coagulation', 'cellular response to dexamethasone stimulus', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to luteinizing hormone stimulus', 'fibrinolysis', 'negative regulation of fibrinolysis', 'negative regulation of plasminogen activation', 'negative regulation of proteolysis', 'plasminogen activation', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of ovulation', 'prevention of polyspermy', 'protein modification process', 'proteolysis', 'regulation of synaptic plasticity', 'response to cAMP', 'response to fatty acid', 'response to hypoxia', 'smooth muscle cell migration', 'synaptic transmission, glutamatergic', 'trans-synaptic signaling by BDNF, modulating synaptic transmission']['blood coagulation', 'cellular response to dexamethasone stimulus', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to luteinizing hormone stimulus', 'fibrinolysis', 'negative regulation of fibrinolysis', 'negative regulation of plasminogen activation', 'negative regulation of proteolysis', 'plasminogen activation', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of ovulation', 'prevention of polyspermy', 'protein modification process', 'proteolysis', 'regulation of synaptic plasticity', 'response to cAMP', 'response to fatty acid', 'response to hypoxia', 'smooth muscle cell migration', 'synaptic transmission, glutamatergic', 'trans-synaptic signaling by BDNF, modulating synaptic transmission']
C-type lectin domain family 2 member D
80
C-type lectin domain family 2 member D
80
9.6
64
0.16
Q91V08Q91V08['cellular defense response', 'negative regulation of osteoclast differentiation', 'protection from natural killer cell mediated cytotoxicity']['cellular defense response', 'negative regulation of osteoclast differentiation', 'protection from natural killer cell mediated cytotoxicity']
Defensin-6
72
Defensin-6
72
3.9
68
0.37
Q01524Q01524['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism']
LINE-1 retrotransposable element ORF1 protein
111
LINE-1 retrotransposable element ORF1 protein
111
3.6
51
0.55
Q15605Q15605['transposition, RNA-mediated']['transposition, RNA-mediated']
Bcl-2-related protein A1
4
Bcl-2-related protein A1
4
2.1
55
0.88
Q16548Q16548['extrinsic apoptotic signaling pathway in absence of ligand', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of apoptotic process']['extrinsic apoptotic signaling pathway in absence of ligand', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of apoptotic process']
Neutrophil defensin 1
83
Neutrophil defensin 1
83
4.0
107
0.24
P59665P59665['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']
Defensin alpha 4
65
Defensin alpha 4
82
9.0
63
0.18
P12838P12838['antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'antimicrobial humoral response', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism', 'T cell chemotaxis']['antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'antimicrobial humoral response', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism', 'T cell chemotaxis']
Hepatocyte growth factor receptor
584
Hepatocyte growth factor receptor
26
2.0
60
0.82
P08581P08581['branching morphogenesis of an epithelial tube', 'cell migration', 'cell surface receptor signaling pathway', 'endothelial cell morphogenesis', 'establishment of skin barrier', 'liver development', 'negative regulation of autophagy', 'negative regulation of guanyl-nucleotide exchange factor activity', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of Rho protein signal transduction', 'negative regulation of stress fiber assembly', 'negative regulation of thrombin-activated receptor signaling pathway', 'nervous system development', 'neuron differentiation', 'pancreas development', 'phagocytosis', 'positive chemotaxis', 'positive regulation of endothelial cell chemotaxis', 'positive regulation of kinase activity', 'positive regulation of microtubule polymerization', 'positive regulation of protein kinase B signaling', 'positive regulation of transcription by RNA polymerase II', 'semaphorin-plexin signaling pathway', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway']['branching morphogenesis of an epithelial tube', 'cell migration', 'cell surface receptor signaling pathway', 'endothelial cell morphogenesis', 'establishment of skin barrier', 'liver development', 'negative regulation of autophagy', 'negative regulation of guanyl-nucleotide exchange factor activity', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of Rho protein signal transduction', 'negative regulation of stress fiber assembly', 'negative regulation of thrombin-activated receptor signaling pathway', 'nervous system development', 'neuron differentiation', 'pancreas development', 'phagocytosis', 'positive chemotaxis', 'positive regulation of endothelial cell chemotaxis', 'positive regulation of kinase activity', 'positive regulation of microtubule polymerization', 'positive regulation of protein kinase B signaling', 'positive regulation of transcription by RNA polymerase II', 'semaphorin-plexin signaling pathway', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Neutrophil defensin 1
83
Neutrophil defensin 1
66
9.5
62
0.17
P59665P59665['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']
PRSS3 protein
52
Amyloid beta precursor like protein 2
319
9.0
89
0.12
Q8N2U3Q06481['proteolysis']['axonogenesis', 'central nervous system development', 'G protein-coupled receptor signaling pathway', 'regulation of cellular protein metabolic process']
Hepatocyte growth factor
487
Hepatocyte growth factor
612
9.3
70
0.15
P14210P14210['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'mitotic cell cycle', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of autophagy', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'mitotic cell cycle', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of autophagy', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']
Nitric oxide synthase, endothelial
101
Nitric oxide synthase, endothelial
101
3.7
83
0.32
P29473P29473['arginine catabolic process', 'blood coagulation', 'cellular response to laminar fluid shear stress', 'mitochondrion organization', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of leukocyte cell-cell adhesion', 'nitric oxide biosynthetic process', 'positive regulation of guanylate cyclase activity']['arginine catabolic process', 'blood coagulation', 'cellular response to laminar fluid shear stress', 'mitochondrion organization', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of leukocyte cell-cell adhesion', 'nitric oxide biosynthetic process', 'positive regulation of guanylate cyclase activity']
FAD-linked sulfhydryl oxidase ALR
197
FAD-linked sulfhydryl oxidase ALR
88
2.0
nan
nan
Q63042Q63042['cellular response to actinomycin D', 'cellular response to lipopolysaccharide', 'cellular response to toxic substance', 'cellular response to tumor necrosis factor', 'liver development', 'liver regeneration', 'negative regulation of apoptotic process', 'negative regulation of natural killer cell mediated cytotoxicity', 'negative regulation of oxidative stress-induced neuron death', 'positive regulation of DNA biosynthetic process', 'response to lipopolysaccharide']['cellular response to actinomycin D', 'cellular response to lipopolysaccharide', 'cellular response to toxic substance', 'cellular response to tumor necrosis factor', 'liver development', 'liver regeneration', 'negative regulation of apoptotic process', 'negative regulation of natural killer cell mediated cytotoxicity', 'negative regulation of oxidative stress-induced neuron death', 'positive regulation of DNA biosynthetic process', 'response to lipopolysaccharide']
TNFAIP3-interacting protein 2
275
TNFAIP3-interacting protein 2
275
2.0
34
1.45
Q8NFZ5Q8NFZ5['apoptotic process', 'CD40 signaling pathway', 'cellular response to lipopolysaccharide', 'inflammatory response', 'interleukin-1-mediated signaling pathway', 'negative regulation of endothelial cell apoptotic process', 'positive regulation of B cell activation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of macrophage activation', 'positive regulation of transcription by RNA polymerase II', 'protein stabilization', 'regulation of transcription by RNA polymerase II', 'toll-like receptor 2 signaling pathway', 'toll-like receptor 3 signaling pathway', 'toll-like receptor 9 signaling pathway']['apoptotic process', 'CD40 signaling pathway', 'cellular response to lipopolysaccharide', 'inflammatory response', 'interleukin-1-mediated signaling pathway', 'negative regulation of endothelial cell apoptotic process', 'positive regulation of B cell activation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of macrophage activation', 'positive regulation of transcription by RNA polymerase II', 'protein stabilization', 'regulation of transcription by RNA polymerase II', 'toll-like receptor 2 signaling pathway', 'toll-like receptor 3 signaling pathway', 'toll-like receptor 9 signaling pathway']
Cryptochrome-2
432
Period circadian protein homolog 2
1213
3.9
67
0.38
Q9R194O54943['circadian regulation of gene expression', 'circadian rhythm', 'entrainment of circadian clock by photoperiod', 'glucose homeostasis', 'lipid storage', 'negative regulation of circadian rhythm', 'negative regulation of glucocorticoid receptor signaling pathway', 'negative regulation of glucocorticoid secretion', 'negative regulation of phosphoprotein phosphatase activity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'protein import into nucleus', 'regulation of circadian rhythm', 'regulation of sodium-dependent phosphate transport', 'response to activity', 'response to insulin', 'response to light stimulus']['circadian regulation of gene expression', 'circadian regulation of translation', 'circadian rhythm', 'entrainment of circadian clock by photoperiod', 'fatty acid metabolic process', 'gluconeogenesis', 'glycogen biosynthetic process', 'histone H3 deacetylation', 'lactate biosynthetic process', 'negative regulation of circadian rhythm', 'negative regulation of DNA-templated transcription, termination', 'negative regulation of fat cell proliferation', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription regulatory region DNA binding', 'negative regulation of transcription, DNA-templated', 'positive regulation of cold-induced thermogenesis', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of glutamate uptake involved in transmission of nerve impulse', 'regulation of insulin secretion', 'regulation of neurogenesis', 'regulation of vasoconstriction', 'response to ischemia', 'white fat cell differentiation']
LINE-1 type transposase domain-containing protein 1
278
LINE-1 type transposase domain-containing protein 1
278
3.5
57
0.5
Q5T7N2Q5T7N2['transposition, RNA-mediated']['transposition, RNA-mediated']
Geranylgeranyl transferase type-2 subunit beta
240
Synaptobrevin homolog YKT6
194
3.5
nan
nan
P53611O15498['protein geranylgeranylation', 'protein modification process', 'protein prenylation', 'visual perception']['endoplasmic reticulum to Golgi vesicle-mediated transport', 'protein transport', 'retrograde transport, endosome to Golgi', 'vesicle docking involved in exocytosis', 'vesicle targeting']
Peroxiredoxin-4
124
Peroxiredoxin-4
245
2.4
42
1.0
1
✔Q13162Q13162['cell redox homeostasis', 'extracellular matrix organization', 'I-kappaB phosphorylation', 'male gonad development', 'negative regulation of male germ cell proliferation', 'peptidyl-proline hydroxylation to 4-hydroxy-L-proline', 'protein maturation by protein folding', 'reactive oxygen species metabolic process', 'response to oxidative stress', 'spermatogenesis']['cell redox homeostasis', 'extracellular matrix organization', 'I-kappaB phosphorylation', 'male gonad development', 'negative regulation of male germ cell proliferation', 'peptidyl-proline hydroxylation to 4-hydroxy-L-proline', 'protein maturation by protein folding', 'reactive oxygen species metabolic process', 'response to oxidative stress', 'spermatogenesis']
Inhibitor of nuclear factor kappa-B kinase subunit beta
662
Inhibitor of nuclear factor kappa-B kinase subunit beta
662
7.3
49
0.28
O14920O14920['antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent', 'cellular response to tumor necrosis factor', 'cortical actin cytoskeleton organization', 'Fc-epsilon receptor signaling pathway', 'I-kappaB kinase/NF-kappaB signaling', 'inflammatory response', 'innate immune response', 'interleukin-1-mediated signaling pathway', 'negative regulation of bicellular tight junction assembly', 'negative regulation of myosin-light-chain-phosphatase activity', 'peptidyl-serine phosphorylation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein localization to plasma membrane', 'protein phosphorylation', 'regulation of establishment of endothelial barrier', 'regulation of phosphorylation', 'regulation of tumor necrosis factor-mediated signaling pathway', 'response to virus', 'stimulatory C-type lectin receptor signaling pathway', 'stress-activated MAPK cascade', 'T cell receptor signaling pathway', 'tumor necrosis factor-mediated signaling pathway']['antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent', 'cellular response to tumor necrosis factor', 'cortical actin cytoskeleton organization', 'Fc-epsilon receptor signaling pathway', 'I-kappaB kinase/NF-kappaB signaling', 'inflammatory response', 'innate immune response', 'interleukin-1-mediated signaling pathway', 'negative regulation of bicellular tight junction assembly', 'negative regulation of myosin-light-chain-phosphatase activity', 'peptidyl-serine phosphorylation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein localization to plasma membrane', 'protein phosphorylation', 'regulation of establishment of endothelial barrier', 'regulation of phosphorylation', 'regulation of tumor necrosis factor-mediated signaling pathway', 'response to virus', 'stimulatory C-type lectin receptor signaling pathway', 'stress-activated MAPK cascade', 'T cell receptor signaling pathway', 'tumor necrosis factor-mediated signaling pathway']
Vam6/Vps39-like protein
877
Vam6/Vps39-like protein
852
8.7
47
0.24
Q96JC1Q96JC1['autophagosome-lysosome fusion', 'autophagy', 'endocytic recycling', 'endosomal vesicle fusion', 'endosome to lysosome transport', 'intracellular protein transport', 'late endosome to lysosome transport', 'regulation of SNARE complex assembly']['autophagosome-lysosome fusion', 'autophagy', 'endocytic recycling', 'endosomal vesicle fusion', 'endosome to lysosome transport', 'intracellular protein transport', 'late endosome to lysosome transport', 'regulation of SNARE complex assembly']
Beta-microseminoprotein
22
Beta-microseminoprotein
70
9.9
54
0.19
P08118P08118[][]
Placenta growth factor
77
Placenta growth factor
130
9.2
61
0.18
P49763P49763['animal organ regeneration', 'cell differentiation', 'cell-cell signaling', 'cellular response to hormone stimulus', 'female pregnancy', 'induction of positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell proliferation', 'positive regulation of mast cell chemotaxis', 'positive regulation of protein phosphorylation', 'response to hypoxia', 'response to xenobiotic stimulus', 'signal transduction', 'sprouting angiogenesis', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor signaling pathway']['animal organ regeneration', 'cell differentiation', 'cell-cell signaling', 'cellular response to hormone stimulus', 'female pregnancy', 'induction of positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell proliferation', 'positive regulation of mast cell chemotaxis', 'positive regulation of protein phosphorylation', 'response to hypoxia', 'response to xenobiotic stimulus', 'signal transduction', 'sprouting angiogenesis', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor signaling pathway']
Cryptochrome-1
414
Period circadian protein homolog 2
1213
3.9
59
0.43
P97784O54943['circadian regulation of gene expression', 'circadian rhythm', 'DNA damage induced protein phosphorylation', 'entrainment of circadian clock by photoperiod', 'gluconeogenesis', 'glucose homeostasis', 'lipid storage', 'negative regulation of circadian rhythm', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of glucocorticoid receptor signaling pathway', 'negative regulation of glucocorticoid secretion', 'negative regulation of gluconeogenesis', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of protein ubiquitination', 'regulation of circadian rhythm', 'regulation of DNA damage checkpoint', 'response to activity', 'response to glucagon', 'response to insulin', 'response to light stimulus']['circadian regulation of gene expression', 'circadian regulation of translation', 'circadian rhythm', 'entrainment of circadian clock by photoperiod', 'fatty acid metabolic process', 'gluconeogenesis', 'glycogen biosynthetic process', 'histone H3 deacetylation', 'lactate biosynthetic process', 'negative regulation of circadian rhythm', 'negative regulation of DNA-templated transcription, termination', 'negative regulation of fat cell proliferation', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription regulatory region DNA binding', 'negative regulation of transcription, DNA-templated', 'positive regulation of cold-induced thermogenesis', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of glutamate uptake involved in transmission of nerve impulse', 'regulation of insulin secretion', 'regulation of neurogenesis', 'regulation of vasoconstriction', 'response to ischemia', 'white fat cell differentiation']
Amyloid-beta precursor protein
300
Amyloid-beta precursor protein
324
2.1
33
1.47
P05067P05067['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Cryptochrome-2
430
Period circadian protein homolog 2
1213
9.0
68
0.16
Q9R194O54943['circadian regulation of gene expression', 'circadian rhythm', 'entrainment of circadian clock by photoperiod', 'glucose homeostasis', 'lipid storage', 'negative regulation of circadian rhythm', 'negative regulation of glucocorticoid receptor signaling pathway', 'negative regulation of glucocorticoid secretion', 'negative regulation of phosphoprotein phosphatase activity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'protein import into nucleus', 'regulation of circadian rhythm', 'regulation of sodium-dependent phosphate transport', 'response to activity', 'response to insulin', 'response to light stimulus']['circadian regulation of gene expression', 'circadian regulation of translation', 'circadian rhythm', 'entrainment of circadian clock by photoperiod', 'fatty acid metabolic process', 'gluconeogenesis', 'glycogen biosynthetic process', 'histone H3 deacetylation', 'lactate biosynthetic process', 'negative regulation of circadian rhythm', 'negative regulation of DNA-templated transcription, termination', 'negative regulation of fat cell proliferation', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription regulatory region DNA binding', 'negative regulation of transcription, DNA-templated', 'positive regulation of cold-induced thermogenesis', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of glutamate uptake involved in transmission of nerve impulse', 'regulation of insulin secretion', 'regulation of neurogenesis', 'regulation of vasoconstriction', 'response to ischemia', 'white fat cell differentiation']
Spondin-1
182
Spondin-1
156
8.4
66
0.18
Q9HCB6Q9HCB6['cell adhesion', 'negative regulation of amyloid-beta formation', 'positive regulation of amyloid precursor protein catabolic process', 'positive regulation of protein binding', 'positive regulation of protein processing', 'protein processing']['cell adhesion', 'negative regulation of amyloid-beta formation', 'positive regulation of amyloid precursor protein catabolic process', 'positive regulation of protein binding', 'positive regulation of protein processing', 'protein processing']
Platelet factor 4
25
Platelet factor 4
67
9.9
72
0.14
P02777P02777['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'inflammatory response', 'leukocyte chemotaxis', 'negative regulation of angiogenesis', 'negative regulation of megakaryocyte differentiation', 'neutrophil chemotaxis', 'platelet activation', 'positive regulation of transcription by RNA polymerase II', 'regulation of cell population proliferation']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'inflammatory response', 'leukocyte chemotaxis', 'negative regulation of angiogenesis', 'negative regulation of megakaryocyte differentiation', 'neutrophil chemotaxis', 'platelet activation', 'positive regulation of transcription by RNA polymerase II', 'regulation of cell population proliferation']
Platelet-derived growth factor subunit A
179
Platelet-derived growth factor subunit A
123
9.9
61
0.17
P04085P04085['actin cytoskeleton organization', 'angiogenesis', 'animal organ morphogenesis', 'cell activation', 'cell projection assembly', 'cell-cell signaling', 'cellular response to transforming growth factor beta stimulus', 'embryonic lung development', 'hair follicle development', 'inner ear development', 'lung alveolus development', 'male gonad development', 'negative chemotaxis', 'negative regulation of phosphatidylinositol biosynthetic process', 'negative regulation of platelet activation', 'platelet-derived growth factor receptor signaling pathway', 'platelet-derived growth factor receptor-alpha signaling pathway', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mesenchymal cell proliferation', 'positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'regulation of actin cytoskeleton organization', 'regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of smooth muscle cell migration', 'response to estradiol', 'response to hypoxia', 'response to inorganic substance', 'response to retinoic acid', 'response to wounding', 'response to xenobiotic stimulus', 'skin development', 'wound healing']['actin cytoskeleton organization', 'angiogenesis', 'animal organ morphogenesis', 'cell activation', 'cell projection assembly', 'cell-cell signaling', 'cellular response to transforming growth factor beta stimulus', 'embryonic lung development', 'hair follicle development', 'inner ear development', 'lung alveolus development', 'male gonad development', 'negative chemotaxis', 'negative regulation of phosphatidylinositol biosynthetic process', 'negative regulation of platelet activation', 'platelet-derived growth factor receptor signaling pathway', 'platelet-derived growth factor receptor-alpha signaling pathway', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mesenchymal cell proliferation', 'positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'regulation of actin cytoskeleton organization', 'regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of smooth muscle cell migration', 'response to estradiol', 'response to hypoxia', 'response to inorganic substance', 'response to retinoic acid', 'response to wounding', 'response to xenobiotic stimulus', 'skin development', 'wound healing']
IGH@ protein
238
Uncharacterized protein
239
2.0
nan
nan
Q6GMX6Q8TCD0[][]
FAD-linked sulfhydryl oxidase ALR
95
FAD-linked sulfhydryl oxidase ALR
204
2.0
41
1.21
P55789P55789['cellular response to actinomycin D', 'cellular response to lipopolysaccharide', 'cellular response to toxic substance', 'cellular response to tumor necrosis factor', 'liver development', 'liver regeneration', 'negative regulation of apoptotic process', 'negative regulation of natural killer cell mediated cytotoxicity', 'negative regulation of oxidative stress-induced neuron death', 'positive regulation of DNA biosynthetic process']['cellular response to actinomycin D', 'cellular response to lipopolysaccharide', 'cellular response to toxic substance', 'cellular response to tumor necrosis factor', 'liver development', 'liver regeneration', 'negative regulation of apoptotic process', 'negative regulation of natural killer cell mediated cytotoxicity', 'negative regulation of oxidative stress-induced neuron death', 'positive regulation of DNA biosynthetic process']
Immunoglobulin heavy constant epsilon
209
Immunoglobulin heavy constant epsilon
209
7.4
68
0.2
P01854P01854['adaptive immune response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
NAD-capped RNA hydrolase NUDT12
117
NAD-capped RNA hydrolase NUDT12
400
9.3
74
0.14
Q9BQG2Q9BQG2['circadian regulation of gene expression', 'methylguanosine-cap decapping', 'mRNA catabolic process', 'NAD biosynthesis via nicotinamide riboside salvage pathway', 'NAD catabolic process', 'NAD-cap decapping', 'NADH metabolic process', 'NADP catabolic process']['circadian regulation of gene expression', 'methylguanosine-cap decapping', 'mRNA catabolic process', 'NAD biosynthesis via nicotinamide riboside salvage pathway', 'NAD catabolic process', 'NAD-cap decapping', 'NADH metabolic process', 'NADP catabolic process']
Interleukin-6 receptor subunit alpha
165
Interleukin-6 receptor subunit alpha
132
8.2
65
0.19
P08887P08887['acute-phase response', 'ciliary neurotrophic factor-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'endocrine pancreas development', 'extrinsic apoptotic signaling pathway', 'hepatic immune response', 'interleukin-6-mediated signaling pathway', 'monocyte chemotaxis', 'negative regulation of collagen biosynthetic process', 'negative regulation of interleukin-8 production', 'neutrophil mediated immunity', 'positive regulation of activation of Janus kinase activity', 'positive regulation of cell population proliferation', 'positive regulation of chemokine production', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of interleukin-6 production', 'positive regulation of leukocyte chemotaxis', 'positive regulation of MAPK cascade', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of platelet aggregation', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'response to cytokine', 'T-helper 17 cell lineage commitment', 'vascular endothelial growth factor production']['acute-phase response', 'ciliary neurotrophic factor-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'endocrine pancreas development', 'extrinsic apoptotic signaling pathway', 'hepatic immune response', 'interleukin-6-mediated signaling pathway', 'monocyte chemotaxis', 'negative regulation of collagen biosynthetic process', 'negative regulation of interleukin-8 production', 'neutrophil mediated immunity', 'positive regulation of activation of Janus kinase activity', 'positive regulation of cell population proliferation', 'positive regulation of chemokine production', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of interleukin-6 production', 'positive regulation of leukocyte chemotaxis', 'positive regulation of MAPK cascade', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of platelet aggregation', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'response to cytokine', 'T-helper 17 cell lineage commitment', 'vascular endothelial growth factor production']
Platelet factor 4 variant
46
Platelet factor 4 variant
86
9.3
69
0.16
P10720P10720['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'inflammatory response', 'neutrophil chemotaxis', 'platelet activation']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'inflammatory response', 'neutrophil chemotaxis', 'platelet activation']
Insulin
31
Insulin
31
8.1
61
0.2
A6XGL2A6XGL2['glucose metabolic process']['glucose metabolic process']
Hepatocyte growth factor
487
Hepatocyte growth factor
679
8.0
73
0.17
P14210P14210['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'mitotic cell cycle', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of autophagy', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'mitotic cell cycle', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of autophagy', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']
T-cell surface glycoprotein CD3 epsilon chain
119
T-cell surface glycoprotein CD3 delta chain
93
4.7
43
0.49
P07766P04234['adaptive immune response', 'alpha-beta T cell activation', 'apoptotic signaling pathway', 'calcium-mediated signaling', 'CD4-positive, alpha-beta T cell proliferation', 'cell surface receptor signaling pathway', 'cerebellum development', 'dendrite development', 'G protein-coupled receptor signaling pathway', 'gamma-delta T cell activation', 'negative regulation of gene expression', 'negative regulation of smoothened signaling pathway', 'negative thymic T cell selection', 'peptidyl-tyrosine phosphorylation', 'positive regulation of calcium-mediated signaling', 'positive regulation of CD4-positive, alpha-beta T cell proliferation', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cell-matrix adhesion', 'positive regulation of gene expression', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-2 production', 'positive regulation of interleukin-4 production', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of T cell anergy', 'positive regulation of T cell proliferation', 'positive thymic T cell selection', 'protein-containing complex assembly', 'regulation of apoptotic process', 'signal complex assembly', 'smoothened signaling pathway', 'T cell activation', 'T cell anergy', 'T cell costimulation', 'T cell receptor signaling pathway', 'transmembrane receptor protein tyrosine kinase signaling pathway']['adaptive immune response', 'alpha-beta T cell activation', 'cell surface receptor signaling pathway', 'positive thymic T cell selection', 'T cell receptor signaling pathway']
7SK snRNA methylphosphate capping enzyme
419
7SK snRNA methylphosphate capping enzyme
419
2.0
83
0.6
Q7L2J0Q7L2J0['negative regulation of chromatin binding', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of G1/S transition of mitotic cell cycle', 'positive regulation of protein localization to Cajal body', 'positive regulation of snRNA transcription by RNA polymerase II', 'RNA methylation', 'snRNA metabolic process', 'snRNA modification']['negative regulation of chromatin binding', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of G1/S transition of mitotic cell cycle', 'positive regulation of protein localization to Cajal body', 'positive regulation of snRNA transcription by RNA polymerase II', 'RNA methylation', 'snRNA metabolic process', 'snRNA modification']
PRSS3 protein
68
Amyloid-beta precursor protein
300
8.5
94
0.12
Q8N2U3P05067['proteolysis']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Proprotein convertase subtilisin/kexin type 9
378
Low-density lipoprotein receptor
318
8.2
75
0.16
Q8NBP7Q59FQ1['apoptotic process', 'cellular response to insulin stimulus', 'cellular response to starvation', 'cholesterol homeostasis', 'cholesterol metabolic process', 'kidney development', 'lipoprotein metabolic process', 'liver development', 'low-density lipoprotein particle receptor catabolic process', 'lysosomal transport', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of low-density lipoprotein particle receptor binding', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of receptor internalization', 'negative regulation of receptor recycling', 'negative regulation of receptor-mediated endocytosis involved in cholesterol transport', 'negative regulation of sodium ion transmembrane transporter activity', 'neurogenesis', 'neuron differentiation', 'phospholipid metabolic process', 'positive regulation of low-density lipoprotein particle receptor catabolic process', 'positive regulation of neuron apoptotic process', 'positive regulation of receptor internalization', 'protein autoprocessing', 'regulation of neuron apoptotic process', 'regulation of signaling receptor activity', 'triglyceride metabolic process']['amyloid-beta clearance', 'amyloid-beta clearance by cellular catabolic process', 'artery morphogenesis', 'cellular response to fatty acid', 'cellular response to low-density lipoprotein particle stimulus', 'cholesterol homeostasis', 'cholesterol import', 'cholesterol metabolic process', 'cholesterol transport', 'endocytosis', 'high-density lipoprotein particle clearance', 'intestinal cholesterol absorption', 'lipid metabolic process', 'lipoprotein catabolic process', 'long-term memory', 'low-density lipoprotein particle clearance', 'negative regulation of amyloid fibril formation', 'negative regulation of astrocyte activation', 'negative regulation of gene expression', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of microglial cell activation', 'negative regulation of protein metabolic process', 'negative regulation of receptor recycling', 'phagocytosis', 'phospholipid transport', 'plasma lipoprotein particle clearance', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of lysosomal protein catabolic process', 'positive regulation of triglyceride biosynthetic process', 'receptor-mediated endocytosis', 'receptor-mediated endocytosis involved in cholesterol transport', 'regulation of cholesterol metabolic process', 'regulation of phosphatidylcholine catabolic process', 'regulation of protein metabolic process', 'response to caloric restriction']
GTP-binding protein GEM
215
GTP-binding protein GEM
106
8.0
65
0.19
P55040P55040['cell surface receptor signaling pathway', 'chromosome organization', 'immune response', 'metaphase plate congression', 'mitotic cell cycle', 'negative regulation of high voltage-gated calcium channel activity', 'signal transduction']['cell surface receptor signaling pathway', 'chromosome organization', 'immune response', 'metaphase plate congression', 'mitotic cell cycle', 'negative regulation of high voltage-gated calcium channel activity', 'signal transduction']
Retinoblastoma-like protein 1
846
AT-rich interactive domain-containing protein 4A
959
9.3
73
0.15
P28749P29374['cell cycle', 'cell differentiation', 'chromatin organization', 'negative regulation of cellular senescence', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'regulation of cell division', 'regulation of lipid kinase activity']['erythrocyte development', 'establishment of Sertoli cell barrier', 'histone H3-K4 trimethylation', 'histone H3-K9 trimethylation', 'histone H4-K20 trimethylation', 'negative regulation of cell migration', 'negative regulation of stem cell population maintenance', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'positive regulation of stem cell population maintenance', 'positive regulation of transcription by RNA polymerase II', 'regulation of gene expression by genomic imprinting', 'regulation of transcription by RNA polymerase II', 'spermatogenesis', 'transcription by RNA polymerase II']
Tumor suppressor candidate 3
99
Interleukin-1 receptor accessory protein-like 1
216
2.0
52
0.94
Q13454Q9NZN1['cognition', 'magnesium ion transport', 'protein N-linked glycosylation', 'protein N-linked glycosylation via asparagine', 'transmembrane transport']['heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules', 'negative regulation of exocytosis', 'neuron differentiation', 'positive regulation of dendrite morphogenesis', 'positive regulation of synapse assembly', 'presynaptic membrane assembly', 'regulation of neuron projection development', 'regulation of postsynapse organization', 'regulation of presynapse assembly', 'signal transduction', 'trans-synaptic signaling by trans-synaptic complex']
Glycoprotein hormones alpha chain
31
Follitropin subunit beta
102
6.7
54
0.28
Q96QJ4P01225[]['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Neuroblastoma suppressor of tumorigenicity 1
82
Neuroblastoma suppressor of tumorigenicity 1
63
8.1
77
0.16
P41271P41271['animal organ morphogenesis', 'determination of dorsal identity', 'negative regulation of BMP signaling pathway', 'negative regulation of monocyte chemotaxis', 'nervous system development', 'neuron projection morphogenesis', 'positive regulation of neuron differentiation', 'sequestering of BMP from receptor via BMP binding', 'sequestering of BMP in extracellular matrix']['animal organ morphogenesis', 'determination of dorsal identity', 'negative regulation of BMP signaling pathway', 'negative regulation of monocyte chemotaxis', 'nervous system development', 'neuron projection morphogenesis', 'positive regulation of neuron differentiation', 'sequestering of BMP from receptor via BMP binding', 'sequestering of BMP in extracellular matrix']
Microtubule-associated protein RP/EB family member 1
228
Microtubule-associated protein RP/EB family member 3
237
8.6
55
0.21
Q15691Q9UPY8['attachment of mitotic spindle microtubules to kinetochore', 'cell division', 'cell migration', 'establishment of mitotic spindle orientation', 'microtubule bundle formation', 'microtubule polymerization', 'negative regulation of microtubule polymerization', 'non-motile cilium assembly', 'positive regulation of microtubule plus-end binding', 'positive regulation of microtubule polymerization', 'protein localization', 'protein localization to astral microtubule', 'protein localization to centrosome', 'protein localization to microtubule', 'protein localization to microtubule plus-end', 'regulation of microtubule polymerization or depolymerization', 'spindle assembly']['cell division', 'positive regulation of cyclin-dependent protein serine/threonine kinase activity', 'positive regulation of microtubule plus-end binding', 'positive regulation of protein kinase activity', 'positive regulation of transcription, DNA-templated', 'protein localization', 'protein localization to microtubule plus-end', 'regulation of microtubule polymerization', 'regulation of microtubule polymerization or depolymerization', 'spindle assembly']
Norrin
131
Norrin
131
2.0
67
0.73
Q00604Q00604['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']
Serine/threonine-protein kinase 32A
340
Serine/threonine-protein kinase 32A
340
7.0
45
0.32
Q8WU08Q8WU08['intracellular signal transduction', 'peptidyl-serine phosphorylation']['intracellular signal transduction', 'peptidyl-serine phosphorylation']
C-type lectin domain family 4 member M
265
C-type lectin domain family 4 member M
395
9.3
47
0.23
Q9H2X3Q9H2X3['adaptive immune response', 'antigen processing and presentation', 'cell-cell recognition', 'innate immune response', 'intracellular signal transduction', 'intracellular transport of virus', 'leukocyte cell-cell adhesion', 'peptide antigen transport', 'receptor-mediated endocytosis of virus by host cell', 'receptor-mediated virion attachment to host cell', 'viral entry into host cell', 'viral genome replication', 'virion attachment to host cell']['adaptive immune response', 'antigen processing and presentation', 'cell-cell recognition', 'innate immune response', 'intracellular signal transduction', 'intracellular transport of virus', 'leukocyte cell-cell adhesion', 'peptide antigen transport', 'receptor-mediated endocytosis of virus by host cell', 'receptor-mediated virion attachment to host cell', 'viral entry into host cell', 'viral genome replication', 'virion attachment to host cell']
Nitric oxide synthase, endothelial
96
Nitric oxide synthase, endothelial
101
3.7
77
0.35
P29473P29473['arginine catabolic process', 'blood coagulation', 'cellular response to laminar fluid shear stress', 'mitochondrion organization', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of leukocyte cell-cell adhesion', 'nitric oxide biosynthetic process', 'positive regulation of guanylate cyclase activity']['arginine catabolic process', 'blood coagulation', 'cellular response to laminar fluid shear stress', 'mitochondrion organization', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of leukocyte cell-cell adhesion', 'nitric oxide biosynthetic process', 'positive regulation of guanylate cyclase activity']
PRSS3 protein
52
Amyloid-beta precursor protein
300
9.3
95
0.11
Q8N2U3P05067['proteolysis']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Rap1 GTPase-GDP dissociation stimulator 1
117
Transforming protein RhoA
190
6.8
65
0.23
P52306P61586['angiotensin-activated signaling pathway involved in heart process', 'CAAX-box protein maturation', 'cardiac muscle hypertrophy', 'myosin filament assembly', 'negative regulation of endoplasmic reticulum calcium ion concentration', 'negative regulation of GTPase activity', 'positive regulation of GTPase activity', 'positive regulation of mitochondrial calcium ion concentration', 'protein localization to nucleus', 'regulation of ERK5 cascade', 'regulation of matrix metallopeptidase secretion', 'regulation of mitochondrion organization', 'vascular associated smooth muscle contraction']['actin cytoskeleton organization', 'actin cytoskeleton reorganization', 'actin filament organization', 'alpha-beta T cell lineage commitment', 'androgen receptor signaling pathway', 'angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure', 'apical junction assembly', 'apolipoprotein A-I-mediated signaling pathway', 'beta selection', 'cell junction assembly', 'cell migration', 'cell-matrix adhesion', 'cellular response to chemokine', 'cellular response to cytokine stimulus', 'cellular response to lipopolysaccharide', 'cerebral cortex cell migration', 'cleavage furrow formation', 'cortical cytoskeleton organization', 'cytoplasmic microtubule organization', 'endothelial cell migration', 'endothelial tube lumen extension', 'establishment of epithelial cell apical/basal polarity', 'establishment or maintenance of cell polarity', 'forebrain radial glial cell differentiation', 'GTP metabolic process', 'kidney development', 'mitotic cleavage furrow formation', 'mitotic spindle assembly', 'motor neuron apoptotic process', 'negative chemotaxis', 'negative regulation of cell migration involved in sprouting angiogenesis', 'negative regulation of cell size', 'negative regulation of cell-substrate adhesion', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of intracellular steroid hormone receptor signaling pathway', 'negative regulation of motor neuron apoptotic process', 'negative regulation of neuron differentiation', 'negative regulation of neuron projection development', 'negative regulation of oxidative phosphorylation', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of vascular associated smooth muscle cell migration', 'negative regulation of vascular associated smooth muscle cell proliferation', 'neuron migration', 'neuron projection morphogenesis', 'odontogenesis', 'ossification involved in bone maturation', 'positive regulation of actin filament polymerization', 'positive regulation of alpha-beta T cell differentiation', 'positive regulation of cell growth', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytokinesis', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of leukocyte adhesion to vascular endothelial cell', 'positive regulation of lipase activity', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron differentiation', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of podosome assembly', 'positive regulation of protein serine/threonine kinase activity', 'positive regulation of stress fiber assembly', 'positive regulation of T cell migration', 'positive regulation of translation', 'positive regulation of vascular associated smooth muscle contraction', 'regulation of actin cytoskeleton organization', 'regulation of calcium ion transport', 'regulation of cell migration', 'regulation of cell shape', 'regulation of dendrite development', 'regulation of focal adhesion assembly', 'regulation of microtubule cytoskeleton organization', 'regulation of modification of postsynaptic actin cytoskeleton', 'regulation of neural precursor cell proliferation', 'regulation of osteoblast proliferation', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of transcription by RNA polymerase II', 'response to amino acid', 'response to ethanol', 'response to glucocorticoid', 'response to glucose', 'response to hypoxia', 'response to mechanical stimulus', 'response to xenobiotic stimulus', 'Rho protein signal transduction', 'Roundabout signaling pathway', 'skeletal muscle satellite cell migration', 'skeletal muscle tissue development', 'stress fiber assembly', 'stress-activated protein kinase signaling cascade', 'substantia nigra development', 'substrate adhesion-dependent cell spreading', 'trabecula morphogenesis', 'Wnt signaling pathway, planar cell polarity pathway', 'wound healing, spreading of cells']
Dopamine beta-hydroxylase
154
Dopamine beta-hydroxylase
596
8.1
nan
nan
P09172P09172['behavioral response to ethanol', 'blood vessel remodeling', 'chemical synaptic transmission', 'dopamine catabolic process', 'fear response', 'glucose homeostasis', 'homoiothermy', 'leukocyte mediated immunity', 'leukocyte migration', 'locomotory behavior', 'maternal behavior', 'memory', 'norepinephrine biosynthetic process', 'octopamine biosynthetic process', 'positive regulation of cold-induced thermogenesis', 'positive regulation of vasoconstriction', 'regulation of extrinsic apoptotic signaling pathway', 'regulation of vascular associated smooth muscle cell proliferation', 'regulation of vascular endothelial cell proliferation', 'response to amphetamine', 'response to pain', 'vasoconstriction', 'visual learning']['behavioral response to ethanol', 'blood vessel remodeling', 'chemical synaptic transmission', 'dopamine catabolic process', 'fear response', 'glucose homeostasis', 'homoiothermy', 'leukocyte mediated immunity', 'leukocyte migration', 'locomotory behavior', 'maternal behavior', 'memory', 'norepinephrine biosynthetic process', 'octopamine biosynthetic process', 'positive regulation of cold-induced thermogenesis', 'positive regulation of vasoconstriction', 'regulation of extrinsic apoptotic signaling pathway', 'regulation of vascular associated smooth muscle cell proliferation', 'regulation of vascular endothelial cell proliferation', 'response to amphetamine', 'response to pain', 'vasoconstriction', 'visual learning']
C-type lectin domain family 4 member D
66
C-type lectin domain family 4 member D
83
5.3
85
0.22
Q8WXI8Q8WXI8['adaptive immune response', 'antifungal innate immune response', 'defense response to bacterium', 'Fc-gamma receptor signaling pathway', 'immune response', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of myeloid dendritic cell activation', 'T cell differentiation involved in immune response']['adaptive immune response', 'antifungal innate immune response', 'defense response to bacterium', 'Fc-gamma receptor signaling pathway', 'immune response', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of myeloid dendritic cell activation', 'T cell differentiation involved in immune response']
Ubiquitin-associated protein 1
452
Ubiquitin-associated protein 1
452
2.0
30
1.64
Q9NZ09Q9NZ09['membrane fission', 'multivesicular body assembly', 'protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway', 'ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway']['membrane fission', 'multivesicular body assembly', 'protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway', 'ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway']
Thioredoxin-dependent peroxide reductase, mitochondrial
109
Thioredoxin-dependent peroxide reductase, mitochondrial
230
2.0
45
1.09
1
✔P35705P35705['cell redox homeostasis', 'cellular response to oxidative stress', 'cellular response to reactive oxygen species', 'hydrogen peroxide catabolic process', 'maternal placenta development', 'mitochondrion organization', 'myeloid cell differentiation', 'negative regulation of kinase activity', 'peptidyl-cysteine oxidation', 'positive regulation of cell population proliferation', 'positive regulation of NF-kappaB transcription factor activity', 'regulation of mitochondrial membrane potential', 'response to hydrogen peroxide', 'response to lipopolysaccharide']['cell redox homeostasis', 'cellular response to oxidative stress', 'cellular response to reactive oxygen species', 'hydrogen peroxide catabolic process', 'maternal placenta development', 'mitochondrion organization', 'myeloid cell differentiation', 'negative regulation of kinase activity', 'peptidyl-cysteine oxidation', 'positive regulation of cell population proliferation', 'positive regulation of NF-kappaB transcription factor activity', 'regulation of mitochondrial membrane potential', 'response to hydrogen peroxide', 'response to lipopolysaccharide']
IgG H chain
245
IGL@ protein
235
2.0
nan
nan
S6C4S0Q6IPQ0[][]
5'-AMP-activated protein kinase catalytic subunit alpha-1
425
5'-AMP-activated protein kinase subunit beta-1
194
8.9
51
0.22
Q13131Q9Y478['autophagy', 'bile acid and bile salt transport', 'bile acid signaling pathway', 'CAMKK-AMPK signaling cascade', 'cellular response to calcium ion', 'cellular response to ethanol', 'cellular response to glucose starvation', 'cellular response to glucose stimulus', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to nutrient levels', 'cellular response to organonitrogen compound', 'cellular response to oxidative stress', 'cellular response to prostaglandin E stimulus', 'cellular response to xenobiotic stimulus', 'cholesterol biosynthetic process', 'chromatin organization', 'cold acclimation', 'energy homeostasis', 'fatty acid biosynthetic process', 'fatty acid homeostasis', 'fatty acid oxidation', 'glucose homeostasis', 'glucose metabolic process', 'intracellular signal transduction', 'lipid biosynthetic process', 'lipid droplet disassembly', 'motor behavior', 'negative regulation of apoptotic process', 'negative regulation of gene expression', 'negative regulation of glucosylceramide biosynthetic process', 'negative regulation of hepatocyte apoptotic process', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of lipid catabolic process', 'negative regulation of TOR signaling', 'negative regulation of tubulin deacetylation', 'neuron cellular homeostasis', 'positive regulation of autophagy', 'positive regulation of cell population proliferation', 'positive regulation of cholesterol biosynthetic process', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of mitochondrial transcription', 'positive regulation of peptidyl-lysine acetylation', 'positive regulation of protein localization', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of skeletal muscle tissue development', 'protein localization to lipid droplet', 'protein phosphorylation', 'regulation of bile acid secretion', 'regulation of circadian rhythm', 'regulation of microtubule cytoskeleton organization', 'regulation of peptidyl-serine phosphorylation', 'regulation of stress granule assembly', 'regulation of vesicle-mediated transport', 'response to 17alpha-ethynylestradiol', 'response to activity', 'response to caffeine', 'response to camptothecin', 'response to gamma radiation', 'response to hypoxia', 'response to UV', 'rhythmic process', 'signal transduction', 'Wnt signaling pathway']['cellular response to nutrient levels', 'fatty acid biosynthetic process', 'nail development', 'positive regulation of cold-induced thermogenesis', 'positive regulation of gene expression', 'protein phosphorylation', 'regulation of catalytic activity', 'signal transduction']
17-beta-hydroxysteroid dehydrogenase 14
255
17-beta-hydroxysteroid dehydrogenase 14
255
2.0
66
0.74
Q9BPX1Q9BPX1['steroid catabolic process']['steroid catabolic process']
TNF receptor-associated factor 3
534
TRAF family member-associated NF-kappa-B activator
177
4.9
nan
nan
Q13114Q92844['apoptotic process', 'defense response to virus', 'negative regulation of NF-kappaB transcription factor activity', 'positive regulation of JNK cascade', 'protein K63-linked ubiquitination', 'regulation of apoptotic process', 'regulation of cytokine production', 'regulation of defense response to virus', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of interferon-beta production', 'regulation of proteolysis', 'signal transduction', 'Toll signaling pathway', 'toll-like receptor signaling pathway', 'TRIF-dependent toll-like receptor signaling pathway', 'tumor necrosis factor-mediated signaling pathway', 'type I interferon signaling pathway']['cellular response to DNA damage stimulus', 'cellular response to interleukin-1', 'cellular response to ionizing radiation', 'cellular response to tumor necrosis factor', 'defense response to virus', 'I-kappaB kinase/NF-kappaB signaling', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of protein deubiquitination', 'positive regulation of ubiquitin-specific protease activity', 'signal transduction', 'type I interferon signaling pathway']
Hepatocyte growth factor
487
Hepatocyte growth factor
604
2.0
60
0.82
P14210P14210['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'mitotic cell cycle', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of autophagy', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'mitotic cell cycle', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of autophagy', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']
BRCA1-associated RING domain protein 1
743
BRCA1-associated RING domain protein 1
743
2.0
55
0.9
Q99728Q99728['cellular response to DNA damage stimulus', 'cellular response to ionizing radiation', 'DNA repair', 'DNA strand resection involved in replication fork processing', 'histone H2A K63-linked deubiquitination', 'histone H2A monoubiquitination', 'homologous recombination', 'mitotic G2/M transition checkpoint', 'negative regulation of apoptotic process', 'negative regulation of cell cycle', "negative regulation of mRNA 3'-end processing", 'negative regulation of protein export from nucleus', 'positive regulation of apoptotic process', 'positive regulation of protein catabolic process', 'protein autoubiquitination', 'protein K6-linked ubiquitination', 'protein polyubiquitination', 'protein ubiquitination', 'regulation of cell cycle', 'regulation of DNA damage checkpoint', 'regulation of DNA repair', 'regulation of phosphorylation', 'tissue homeostasis']['cellular response to DNA damage stimulus', 'cellular response to ionizing radiation', 'DNA repair', 'DNA strand resection involved in replication fork processing', 'histone H2A K63-linked deubiquitination', 'histone H2A monoubiquitination', 'homologous recombination', 'mitotic G2/M transition checkpoint', 'negative regulation of apoptotic process', 'negative regulation of cell cycle', "negative regulation of mRNA 3'-end processing", 'negative regulation of protein export from nucleus', 'positive regulation of apoptotic process', 'positive regulation of protein catabolic process', 'protein autoubiquitination', 'protein K6-linked ubiquitination', 'protein polyubiquitination', 'protein ubiquitination', 'regulation of cell cycle', 'regulation of DNA damage checkpoint', 'regulation of DNA repair', 'regulation of phosphorylation', 'tissue homeostasis']
Protein cereblon
325
Protein cereblon
346
4.8
59
0.36
Q8C7D2Q8C7D2['locomotory exploration behavior', 'negative regulation of ion transmembrane transport', 'negative regulation of large conductance calcium-activated potassium channel activity', 'negative regulation of protein-containing complex assembly', 'positive regulation of protein-containing complex assembly', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination']['locomotory exploration behavior', 'negative regulation of ion transmembrane transport', 'negative regulation of large conductance calcium-activated potassium channel activity', 'negative regulation of protein-containing complex assembly', 'positive regulation of protein-containing complex assembly', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination']
Endothelin-1
53
Endothelin-1
55
5.1
57
0.34
P05305P05305['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'artery smooth muscle contraction', 'axon extension', 'axonogenesis involved in innervation', 'body fluid secretion', 'branching involved in blood vessel morphogenesis', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cardiac neural crest cell migration involved in outflow tract morphogenesis', 'cartilage development', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to calcium ion', 'cellular response to fatty acid', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to human chorionic gonadotropin stimulus', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to luteinizing hormone stimulus', 'cellular response to mineralocorticoid stimulus', 'cellular response to organic substance', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to xenobiotic stimulus', 'dorsal/ventral pattern formation', 'embryonic heart tube development', 'endothelin receptor signaling pathway', 'endothelin receptor signaling pathway involved in heart process', 'epithelial fluid transport', 'ERK1 and ERK2 cascade', 'G protein-coupled receptor signaling pathway', 'histamine secretion', 'I-kappaB kinase/NF-kappaB signaling', 'in utero embryonic development', 'inositol phosphate-mediated signaling', 'leukocyte activation', 'maternal process involved in parturition', 'meiotic cell cycle process involved in oocyte maturation', 'membrane depolarization', 'middle ear morphogenesis', 'mitochondrion organization', 'multicellular organism aging', 'negative regulation of blood coagulation', 'negative regulation of gene expression', 'negative regulation of hormone secretion', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein metabolic process', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'neural crest cell fate commitment', 'nitric oxide transport', 'noradrenergic neuron differentiation', 'peptide hormone secretion', 'pharyngeal arch artery morphogenesis', 'phosphatidylinositol 3-kinase signaling', 'phospholipase D-activating G protein-coupled receptor signaling pathway', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cation channel activity', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell size', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell migration', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of JUN kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of odontogenesis', 'positive regulation of prostaglandin secretion', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'positive regulation of renal sodium excretion', 'positive regulation of sarcomere organization', 'positive regulation of signaling receptor activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'prostaglandin biosynthetic process', 'protein kinase A signaling', 'protein kinase C deactivation', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'regulation of glucose transmembrane transport', 'regulation of pH', 'regulation of sensory perception of pain', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'renal sodium ion absorption', 'respiratory gaseous exchange by respiratory system', 'response to activity', 'response to amino acid', 'response to amphetamine', 'response to dexamethasone', 'response to leptin', 'response to lipopolysaccharide', 'response to muscle stretch', 'response to nicotine', 'response to ozone', 'response to prostaglandin F', 'response to salt', 'response to testosterone', 'rhythmic excitation', 'semaphorin-plexin signaling pathway involved in axon guidance', 'sensory perception of pain', 'superoxide anion generation', 'sympathetic neuron axon guidance', 'thyroid gland development', 'transcription by RNA polymerase II', 'vasoconstriction', 'vein smooth muscle contraction']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'artery smooth muscle contraction', 'axon extension', 'axonogenesis involved in innervation', 'body fluid secretion', 'branching involved in blood vessel morphogenesis', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cardiac neural crest cell migration involved in outflow tract morphogenesis', 'cartilage development', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to calcium ion', 'cellular response to fatty acid', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to human chorionic gonadotropin stimulus', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to luteinizing hormone stimulus', 'cellular response to mineralocorticoid stimulus', 'cellular response to organic substance', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to xenobiotic stimulus', 'dorsal/ventral pattern formation', 'embryonic heart tube development', 'endothelin receptor signaling pathway', 'endothelin receptor signaling pathway involved in heart process', 'epithelial fluid transport', 'ERK1 and ERK2 cascade', 'G protein-coupled receptor signaling pathway', 'histamine secretion', 'I-kappaB kinase/NF-kappaB signaling', 'in utero embryonic development', 'inositol phosphate-mediated signaling', 'leukocyte activation', 'maternal process involved in parturition', 'meiotic cell cycle process involved in oocyte maturation', 'membrane depolarization', 'middle ear morphogenesis', 'mitochondrion organization', 'multicellular organism aging', 'negative regulation of blood coagulation', 'negative regulation of gene expression', 'negative regulation of hormone secretion', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein metabolic process', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'neural crest cell fate commitment', 'nitric oxide transport', 'noradrenergic neuron differentiation', 'peptide hormone secretion', 'pharyngeal arch artery morphogenesis', 'phosphatidylinositol 3-kinase signaling', 'phospholipase D-activating G protein-coupled receptor signaling pathway', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cation channel activity', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell size', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell migration', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of JUN kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of odontogenesis', 'positive regulation of prostaglandin secretion', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'positive regulation of renal sodium excretion', 'positive regulation of sarcomere organization', 'positive regulation of signaling receptor activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'prostaglandin biosynthetic process', 'protein kinase A signaling', 'protein kinase C deactivation', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'regulation of glucose transmembrane transport', 'regulation of pH', 'regulation of sensory perception of pain', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'renal sodium ion absorption', 'respiratory gaseous exchange by respiratory system', 'response to activity', 'response to amino acid', 'response to amphetamine', 'response to dexamethasone', 'response to leptin', 'response to lipopolysaccharide', 'response to muscle stretch', 'response to nicotine', 'response to ozone', 'response to prostaglandin F', 'response to salt', 'response to testosterone', 'rhythmic excitation', 'semaphorin-plexin signaling pathway involved in axon guidance', 'sensory perception of pain', 'superoxide anion generation', 'sympathetic neuron axon guidance', 'thyroid gland development', 'transcription by RNA polymerase II', 'vasoconstriction', 'vein smooth muscle contraction']
Natural killer cells antigen CD94
59
NKG2-A/NKG2-B type II integral membrane protein
116
2.0
60
0.82
Q13241P26715['adaptive immune response', 'cell surface receptor signaling pathway', 'natural killer cell mediated immunity', 'negative regulation of natural killer cell mediated cytotoxicity', 'negative regulation of T cell mediated cytotoxicity', 'positive regulation of natural killer cell mediated cytotoxicity', 'regulation of natural killer cell activation', 'stimulatory C-type lectin receptor signaling pathway']['adaptive immune response', 'CD8-positive, gamma-delta intraepithelial T cell differentiation', 'cell surface receptor signaling pathway', 'innate immune response', 'natural killer cell inhibitory signaling pathway', 'negative regulation of natural killer cell mediated cytotoxicity', 'negative regulation of T cell mediated cytotoxicity', 'regulation of natural killer cell activation']
Serine/threonine-protein kinase DCLK1
426
Serine/threonine-protein kinase DCLK1
548
4.6
58
0.37
O15075O15075['axon extension', 'central nervous system development', 'central nervous system projection neuron axonogenesis', 'dendrite morphogenesis', 'endosomal transport', 'forebrain development', 'intracellular signal transduction', 'negative regulation of protein localization to nucleus', 'nervous system development', 'neuron migration', 'neuron projection morphogenesis', 'peptidyl-serine phosphorylation', 'protein localization to nucleus', 'protein phosphorylation', 'response to virus']['axon extension', 'central nervous system development', 'central nervous system projection neuron axonogenesis', 'dendrite morphogenesis', 'endosomal transport', 'forebrain development', 'intracellular signal transduction', 'negative regulation of protein localization to nucleus', 'nervous system development', 'neuron migration', 'neuron projection morphogenesis', 'peptidyl-serine phosphorylation', 'protein localization to nucleus', 'protein phosphorylation', 'response to virus']
Aurora kinase A
290
Aurora kinase A
290
5.3
41
0.46
1
✔O14965O14965['anterior/posterior axis specification', 'apoptotic process', 'cell division', 'centrosome localization', 'cilium disassembly', 'G2/M transition of mitotic cell cycle', 'liver regeneration', 'mitotic cell cycle', 'mitotic centrosome separation', 'mitotic spindle organization', 'negative regulation of apoptotic process', 'negative regulation of gene expression', 'negative regulation of protein binding', 'neuron projection extension', 'peptidyl-serine phosphorylation', 'positive regulation of mitochondrial fission', 'positive regulation of mitotic nuclear division', 'positive regulation of oocyte maturation', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein autophosphorylation', 'protein localization to centrosome', 'protein phosphorylation', 'regulation of centrosome cycle', 'regulation of cytokinesis', 'regulation of G2/M transition of mitotic cell cycle', 'regulation of protein stability', 'regulation of signal transduction by p53 class mediator', 'response to wounding', 'spindle assembly involved in female meiosis I', 'spindle organization']['anterior/posterior axis specification', 'apoptotic process', 'cell division', 'centrosome localization', 'cilium disassembly', 'G2/M transition of mitotic cell cycle', 'liver regeneration', 'mitotic cell cycle', 'mitotic centrosome separation', 'mitotic spindle organization', 'negative regulation of apoptotic process', 'negative regulation of gene expression', 'negative regulation of protein binding', 'neuron projection extension', 'peptidyl-serine phosphorylation', 'positive regulation of mitochondrial fission', 'positive regulation of mitotic nuclear division', 'positive regulation of oocyte maturation', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein autophosphorylation', 'protein localization to centrosome', 'protein phosphorylation', 'regulation of centrosome cycle', 'regulation of cytokinesis', 'regulation of G2/M transition of mitotic cell cycle', 'regulation of protein stability', 'regulation of signal transduction by p53 class mediator', 'response to wounding', 'spindle assembly involved in female meiosis I', 'spindle organization']
Vascular endothelial growth factor receptor 2
862
Vascular endothelial growth factor receptor 2
862
9.9
45
0.22
P35968P35968['angiogenesis', 'blood vessel endothelial cell differentiation', 'branching involved in blood vessel morphogenesis', 'calcium ion homeostasis', 'calcium-mediated signaling using intracellular calcium source', 'cell fate commitment', 'cell migration', 'cell migration involved in sprouting angiogenesis', 'cellular response to hydrogen sulfide', 'cellular response to vascular endothelial growth factor stimulus', 'embryonic hemopoiesis', 'endocardium development', 'endothelial cell differentiation', 'endothelium development', 'epithelial cell maturation', 'epithelial cell proliferation', 'ERK1 and ERK2 cascade', 'hematopoietic progenitor cell differentiation', 'lung alveolus development', 'lymph vessel development', 'mesenchymal cell proliferation', 'negative regulation of apoptotic process', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of gene expression', 'negative regulation of neuron apoptotic process', 'ovarian follicle development', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of angiogenesis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of BMP signaling pathway', 'positive regulation of cell migration', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of kinase activity', 'positive regulation of macroautophagy', 'positive regulation of MAPK cascade', 'positive regulation of mesenchymal cell proliferation', 'positive regulation of mitochondrial depolarization', 'positive regulation of mitochondrial fission', 'positive regulation of nitric-oxide synthase biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of positive chemotaxis', 'positive regulation of protein phosphorylation', 'positive regulation of stem cell proliferation', 'positive regulation of vasculogenesis', 'post-embryonic camera-type eye morphogenesis', 'protein autophosphorylation', 'protein kinase B signaling', 'regulation of bone development', 'regulation of cell shape', 'regulation of hematopoietic progenitor cell differentiation', 'semaphorin-plexin signaling pathway', 'stem cell proliferation', 'surfactant homeostasis', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis']['angiogenesis', 'blood vessel endothelial cell differentiation', 'branching involved in blood vessel morphogenesis', 'calcium ion homeostasis', 'calcium-mediated signaling using intracellular calcium source', 'cell fate commitment', 'cell migration', 'cell migration involved in sprouting angiogenesis', 'cellular response to hydrogen sulfide', 'cellular response to vascular endothelial growth factor stimulus', 'embryonic hemopoiesis', 'endocardium development', 'endothelial cell differentiation', 'endothelium development', 'epithelial cell maturation', 'epithelial cell proliferation', 'ERK1 and ERK2 cascade', 'hematopoietic progenitor cell differentiation', 'lung alveolus development', 'lymph vessel development', 'mesenchymal cell proliferation', 'negative regulation of apoptotic process', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of gene expression', 'negative regulation of neuron apoptotic process', 'ovarian follicle development', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of angiogenesis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of BMP signaling pathway', 'positive regulation of cell migration', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of kinase activity', 'positive regulation of macroautophagy', 'positive regulation of MAPK cascade', 'positive regulation of mesenchymal cell proliferation', 'positive regulation of mitochondrial depolarization', 'positive regulation of mitochondrial fission', 'positive regulation of nitric-oxide synthase biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of positive chemotaxis', 'positive regulation of protein phosphorylation', 'positive regulation of stem cell proliferation', 'positive regulation of vasculogenesis', 'post-embryonic camera-type eye morphogenesis', 'protein autophosphorylation', 'protein kinase B signaling', 'regulation of bone development', 'regulation of cell shape', 'regulation of hematopoietic progenitor cell differentiation', 'semaphorin-plexin signaling pathway', 'stem cell proliferation', 'surfactant homeostasis', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis']
ATPase WRNIP1
23
ATPase WRNIP1
39
7.8
37
0.35
Q96S55Q96S55['DNA synthesis involved in DNA repair', 'DNA-templated DNA replication', 'innate immune response', 'regulation of DNA repair', 'regulation of DNA-templated DNA replication initiation']['DNA synthesis involved in DNA repair', 'DNA-templated DNA replication', 'innate immune response', 'regulation of DNA repair', 'regulation of DNA-templated DNA replication initiation']
Aldo-keto reductase family 1 member C21
5
Aldo-keto reductase family 1 member C21
7
8.9
73
0.15
Q91WR5Q91WR5['daunorubicin metabolic process', 'doxorubicin metabolic process', 'progesterone metabolic process', 'prostaglandin metabolic process', 'steroid biosynthetic process', 'steroid metabolic process']['daunorubicin metabolic process', 'doxorubicin metabolic process', 'progesterone metabolic process', 'prostaglandin metabolic process', 'steroid biosynthetic process', 'steroid metabolic process']
C-type lectin domain family 2 member D
75
C-type lectin domain family 2 member D
75
8.3
75
0.16
Q9UHP7Q9UHP7['cell surface receptor signaling pathway']['cell surface receptor signaling pathway']
C-type lectin domain family 2 member D11
80
C-type lectin domain family 2 member D11
80
8.1
70
0.18
Q0H8B9Q0H8B9[][]
Neuroblastoma suppressor of tumorigenicity 1
82
Neuroblastoma suppressor of tumorigenicity 1
82
4.3
75
0.31
P41271P41271['animal organ morphogenesis', 'determination of dorsal identity', 'negative regulation of BMP signaling pathway', 'negative regulation of monocyte chemotaxis', 'nervous system development', 'neuron projection morphogenesis', 'positive regulation of neuron differentiation', 'sequestering of BMP from receptor via BMP binding', 'sequestering of BMP in extracellular matrix']['animal organ morphogenesis', 'determination of dorsal identity', 'negative regulation of BMP signaling pathway', 'negative regulation of monocyte chemotaxis', 'nervous system development', 'neuron projection morphogenesis', 'positive regulation of neuron differentiation', 'sequestering of BMP from receptor via BMP binding', 'sequestering of BMP in extracellular matrix']
Defensin alpha 5
93
Defensin alpha 5
93
7.7
65
0.2
Q01523Q01523['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']
Tyrosine-protein kinase JAK2
125
Erythropoietin receptor
314
7.7
67
0.19
O60674P19235['actin filament polymerization', 'activation of cysteine-type endopeptidase activity involved in apoptotic process', 'activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'activation of Janus kinase activity', 'adaptive immune response', 'apoptotic process', 'axon regeneration', 'cell differentiation', 'cellular response to dexamethasone stimulus', 'cellular response to interleukin-3', 'cellular response to lipopolysaccharide', 'cellular response to virus', 'chromatin organization', 'collagen-activated signaling pathway', 'cytokine-mediated signaling pathway', 'enzyme-linked receptor protein signaling pathway', 'erythrocyte differentiation', 'extrinsic apoptotic signaling pathway', 'G protein-coupled receptor signaling pathway', 'granulocyte-macrophage colony-stimulating factor signaling pathway', 'growth hormone receptor signaling pathway', 'growth hormone receptor signaling pathway via JAK-STAT', 'immune response', 'interferon-gamma-mediated signaling pathway', 'interleukin-12-mediated signaling pathway', 'interleukin-35-mediated signaling pathway', 'interleukin-6-mediated signaling pathway', 'intracellular signal transduction', 'intrinsic apoptotic signaling pathway in response to oxidative stress', 'mammary gland epithelium development', 'mesoderm development', 'microglial cell activation', 'mineralocorticoid receptor signaling pathway', 'modulation of chemical synaptic transmission', 'negative regulation of cardiac muscle cell apoptotic process', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of DNA binding', 'negative regulation of heart contraction', 'negative regulation of neuron apoptotic process', 'peptidyl-tyrosine phosphorylation', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of apoptotic signaling pathway', 'positive regulation of cell differentiation', 'positive regulation of cell migration', 'positive regulation of cell-substrate adhesion', 'positive regulation of cold-induced thermogenesis', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA binding', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of epithelial cell apoptotic process', 'positive regulation of growth factor dependent skeletal muscle satellite cell proliferation', 'positive regulation of growth hormone receptor signaling pathway', 'positive regulation of inflammatory response', 'positive regulation of insulin secretion', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-17 production', 'positive regulation of leukocyte proliferation', 'positive regulation of MAPK cascade', 'positive regulation of MHC class II biosynthetic process', 'positive regulation of natural killer cell proliferation', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of nitric-oxide synthase biosynthetic process', 'positive regulation of NK T cell proliferation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphoprotein phosphatase activity', 'positive regulation of platelet activation', 'positive regulation of platelet aggregation', 'positive regulation of protein import into nucleus', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of signaling receptor activity', 'positive regulation of SMAD protein signal transduction', 'positive regulation of T cell proliferation', 'positive regulation of T-helper 17 type immune response', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of vascular associated smooth muscle cell proliferation', 'post-embryonic hemopoiesis', 'post-translational protein modification', 'postsynapse to nucleus signaling pathway', 'programmed cell death induced by symbiont', 'protein autophosphorylation', 'protein phosphorylation', 'receptor signaling pathway via JAK-STAT', 'regulation of apoptotic process', 'regulation of inflammatory response', 'regulation of nitric oxide biosynthetic process', 'regulation of receptor signaling pathway via JAK-STAT', 'response to amine', 'response to antibiotic', 'response to hydroperoxide', 'response to interleukin-12', 'response to lipopolysaccharide', 'response to tumor necrosis factor', 'signal transduction', 'transcription by RNA polymerase II', 'tumor necrosis factor-mediated signaling pathway', 'tyrosine phosphorylation of STAT protein']['brain development', 'cytokine-mediated signaling pathway', 'decidualization', 'heart development', 'hemopoiesis', 'positive regulation of cell population proliferation', 'signal transduction']
Pygopus homolog 1
371
Pygopus homolog 1
343
7.5
66
0.2
Q9Y3Y4Q9Y3Y4['canonical Wnt signaling pathway', 'hematopoietic progenitor cell differentiation', 'kidney development', 'positive regulation of transcription by RNA polymerase II', 'protein localization to nucleus', 'spermatid nucleus differentiation']['canonical Wnt signaling pathway', 'hematopoietic progenitor cell differentiation', 'kidney development', 'positive regulation of transcription by RNA polymerase II', 'protein localization to nucleus', 'spermatid nucleus differentiation']
Trypsin-3
121
Tissue factor pathway inhibitor
63
8.4
96
0.12
P35030P10646['antimicrobial humoral response', 'digestion', 'endothelial cell migration', 'proteolysis', 'zymogen activation']['blood coagulation', 'cellular response to steroid hormone stimulus', 'negative regulation of blood coagulation']
Trypsin-3
121
Amyloid-beta precursor protein
300
8.4
96
0.12
P35030P05067['antimicrobial humoral response', 'digestion', 'endothelial cell migration', 'proteolysis', 'zymogen activation']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Trypsin
205
Trypsin
181
7.4
69
0.19
P00761P00761['digestion', 'proteolysis']['digestion', 'proteolysis']
Hepatocyte growth factor
212
Hepatocyte growth factor
212
7.4
88
0.15
Q08048Q08048['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'proteolysis', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'proteolysis', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']
Fibrinogen beta chain
87
Fibrinogen gamma-B chain
32
7.7
65
0.2
P02676P12799['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'innate immune response', 'platelet aggregation', 'protein polymerization']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'platelet aggregation', 'protein polymerization']
NKG2-D type II integral membrane protein
115
NKG2-D type II integral membrane protein
112
7.7
74
0.18
O54709O54709['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of apoptotic process', 'positive regulation of interferon-gamma production', 'positive regulation of myeloid dendritic cell activation', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target', 'positive regulation of nitric oxide biosynthetic process', 'stimulatory C-type lectin receptor signaling pathway']['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of apoptotic process', 'positive regulation of interferon-gamma production', 'positive regulation of myeloid dendritic cell activation', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target', 'positive regulation of nitric oxide biosynthetic process', 'stimulatory C-type lectin receptor signaling pathway']
Neutrophil defensin 3
83
Neutrophil defensin 3
83
5.3
69
0.28
P59666P59666['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to virus', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing of cells of another organism', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to virus', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing of cells of another organism', 'membrane disruption in another organism']
Pygopus homolog 1
346
Pygopus homolog 1
343
8.3
65
0.18
Q9Y3Y4Q9Y3Y4['canonical Wnt signaling pathway', 'hematopoietic progenitor cell differentiation', 'kidney development', 'positive regulation of transcription by RNA polymerase II', 'protein localization to nucleus', 'spermatid nucleus differentiation']['canonical Wnt signaling pathway', 'hematopoietic progenitor cell differentiation', 'kidney development', 'positive regulation of transcription by RNA polymerase II', 'protein localization to nucleus', 'spermatid nucleus differentiation']
Defensin alpha 5
93
Defensin alpha 5
67
7.7
73
0.18
Q01523Q01523['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']
E3 ubiquitin-protein ligase RNF31
551
E3 ubiquitin-protein ligase RNF31
551
8.3
81
0.15
Q96EP0Q96EP0['CD40 signaling pathway', 'defense response to bacterium', 'negative regulation of necroptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of xenophagy', 'protein linear polyubiquitination', 'protein polyubiquitination', 'T cell receptor signaling pathway']['CD40 signaling pathway', 'defense response to bacterium', 'negative regulation of necroptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of xenophagy', 'protein linear polyubiquitination', 'protein polyubiquitination', 'T cell receptor signaling pathway']
Corticotropin-releasing factor receptor 1
393
Corticotropin-releasing factor receptor 1
262
8.3
68
0.18
P34998P34998['activation of adenylate cyclase activity', 'adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'adrenal gland development', 'behavioral response to ethanol', 'cell surface receptor signaling pathway', 'cellular response to corticotropin-releasing hormone stimulus', 'corticotropin secretion', 'fear response', 'female pregnancy', 'general adaptation syndrome, behavioral process', 'immune response', 'negative regulation of voltage-gated calcium channel activity', 'parturition', 'regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway', 'regulation of corticosterone secretion']['activation of adenylate cyclase activity', 'adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'adrenal gland development', 'behavioral response to ethanol', 'cell surface receptor signaling pathway', 'cellular response to corticotropin-releasing hormone stimulus', 'corticotropin secretion', 'fear response', 'female pregnancy', 'general adaptation syndrome, behavioral process', 'immune response', 'negative regulation of voltage-gated calcium channel activity', 'parturition', 'regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway', 'regulation of corticosterone secretion']
Heat shock factor 2-binding protein
128
Heat shock factor 2-binding protein
128
8.3
84
0.14
O75031O75031['double-strand break repair involved in meiotic recombination', 'female meiosis I', 'male meiosis I', 'spermatogenesis', 'transcription by RNA polymerase II']['double-strand break repair involved in meiotic recombination', 'female meiosis I', 'male meiosis I', 'spermatogenesis', 'transcription by RNA polymerase II']
A disintegrin and metalloproteinase with thrombospondin motifs 4
482
A disintegrin and metalloproteinase with thrombospondin motifs 4
482
7.6
74
0.18
O75173O75173['extracellular matrix disassembly', 'extracellular matrix organization', 'proteolysis', 'skeletal system development']['extracellular matrix disassembly', 'extracellular matrix organization', 'proteolysis', 'skeletal system development']
Mothers against decapentaplegic homolog 4
16
Mothers against decapentaplegic homolog 4
25
8.3
60
0.2
P97471P97471['adrenal gland development', 'aging', 'anatomical structure morphogenesis', 'anterior/posterior pattern specification', 'atrioventricular canal development', 'atrioventricular valve formation', 'axon guidance', 'BMP signaling pathway', 'brainstem development', 'branching involved in ureteric bud morphogenesis', 'cardiac septum development', 'cell differentiation', 'cell population proliferation', 'cellular iron ion homeostasis', 'cellular response to glucose stimulus', 'developmental growth', 'embryonic digit morphogenesis', 'endocardial cell differentiation', 'endoderm development', 'endothelial cell activation', 'epithelial to mesenchymal transition involved in endocardial cushion formation', 'ERK1 and ERK2 cascade', 'female gonad development', 'female gonad morphogenesis', 'formation of anatomical boundary', 'gastrulation', 'gastrulation with mouth forming second', 'in utero embryonic development', 'interleukin-6-mediated signaling pathway', 'intracellular signal transduction', 'kidney development', 'left ventricular cardiac muscle tissue morphogenesis', 'male gonad development', 'mesendoderm development', 'mesoderm development', 'metanephric mesenchyme morphogenesis', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of cardiac myofibril assembly', 'negative regulation of cell death', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of protein catabolic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'nephrogenic mesenchyme morphogenesis', 'neural crest cell differentiation', 'neuron fate commitment', 'osteoblast differentiation', 'outflow tract septum morphogenesis', 'ovarian follicle development', 'positive regulation of BMP signaling pathway', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of cell proliferation involved in heart valve morphogenesis', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of follicle-stimulating hormone secretion', 'positive regulation of histone H3-K4 methylation', 'positive regulation of histone H3-K9 acetylation', 'positive regulation of luteinizing hormone secretion', 'positive regulation of miRNA transcription', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta receptor signaling pathway', 'regulation of binding', 'regulation of cell population proliferation', 'regulation of hair follicle development', 'regulation of transcription by RNA polymerase II', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to transforming growth factor beta', 'sebaceous gland development', 'secondary palate development', 'seminiferous tubule development', 'single fertilization', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'somite rostral/caudal axis specification', 'spermatogenesis', 'tissue morphogenesis', 'transcription by RNA polymerase II', 'transcription, DNA-templated', 'transforming growth factor beta receptor signaling pathway', 'uterus development', 'ventricular septum morphogenesis', 'wound healing']['adrenal gland development', 'aging', 'anatomical structure morphogenesis', 'anterior/posterior pattern specification', 'atrioventricular canal development', 'atrioventricular valve formation', 'axon guidance', 'BMP signaling pathway', 'brainstem development', 'branching involved in ureteric bud morphogenesis', 'cardiac septum development', 'cell differentiation', 'cell population proliferation', 'cellular iron ion homeostasis', 'cellular response to glucose stimulus', 'developmental growth', 'embryonic digit morphogenesis', 'endocardial cell differentiation', 'endoderm development', 'endothelial cell activation', 'epithelial to mesenchymal transition involved in endocardial cushion formation', 'ERK1 and ERK2 cascade', 'female gonad development', 'female gonad morphogenesis', 'formation of anatomical boundary', 'gastrulation', 'gastrulation with mouth forming second', 'in utero embryonic development', 'interleukin-6-mediated signaling pathway', 'intracellular signal transduction', 'kidney development', 'left ventricular cardiac muscle tissue morphogenesis', 'male gonad development', 'mesendoderm development', 'mesoderm development', 'metanephric mesenchyme morphogenesis', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of cardiac myofibril assembly', 'negative regulation of cell death', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of protein catabolic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'nephrogenic mesenchyme morphogenesis', 'neural crest cell differentiation', 'neuron fate commitment', 'osteoblast differentiation', 'outflow tract septum morphogenesis', 'ovarian follicle development', 'positive regulation of BMP signaling pathway', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of cell proliferation involved in heart valve morphogenesis', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of follicle-stimulating hormone secretion', 'positive regulation of histone H3-K4 methylation', 'positive regulation of histone H3-K9 acetylation', 'positive regulation of luteinizing hormone secretion', 'positive regulation of miRNA transcription', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta receptor signaling pathway', 'regulation of binding', 'regulation of cell population proliferation', 'regulation of hair follicle development', 'regulation of transcription by RNA polymerase II', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to transforming growth factor beta', 'sebaceous gland development', 'secondary palate development', 'seminiferous tubule development', 'single fertilization', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'somite rostral/caudal axis specification', 'spermatogenesis', 'tissue morphogenesis', 'transcription by RNA polymerase II', 'transcription, DNA-templated', 'transforming growth factor beta receptor signaling pathway', 'uterus development', 'ventricular septum morphogenesis', 'wound healing']
Fractalkine
74
Fractalkine
32
8.3
60
0.2
P78423P78423['aging', 'angiogenesis involved in wound healing', 'autocrine signaling', 'cell adhesion', 'cell chemotaxis', 'cell-cell adhesion', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'defense response', 'eosinophil chemotaxis', 'extrinsic apoptotic signaling pathway in absence of ligand', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'integrin activation', 'leukocyte adhesive activation', 'leukocyte chemotaxis', 'leukocyte migration involved in inflammatory response', 'lymphocyte chemotaxis', 'microglial cell activation', 'microglial cell proliferation', 'monocyte chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of apoptotic signaling pathway', 'negative regulation of cell migration', 'negative regulation of cell-substrate adhesion', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of glutamate receptor signaling pathway', 'negative regulation of hippocampal neuron apoptotic process', 'negative regulation of interleukin-1 alpha production', 'negative regulation of interleukin-1 beta production', 'negative regulation of interleukin-6 production', 'negative regulation of microglial cell activation', 'negative regulation of neuron migration', 'negative regulation of tumor necrosis factor production', 'neuron cellular homeostasis', 'neuron remodeling', 'neutrophil chemotaxis', 'positive chemotaxis', 'positive regulation of actin filament bundle assembly', 'positive regulation of calcium-independent cell-cell adhesion', 'positive regulation of cell population proliferation', 'positive regulation of cell-matrix adhesion', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of I-kappaB phosphorylation', 'positive regulation of inflammatory response', 'positive regulation of MAPK cascade', 'positive regulation of microglial cell migration', 'positive regulation of neuroblast proliferation', 'positive regulation of neuron projection development', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein kinase B signaling', 'positive regulation of release of sequestered calcium ion into cytosol', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transforming growth factor beta1 production', 'regulation of lipopolysaccharide-mediated signaling pathway', 'regulation of neurogenesis', 'regulation of synaptic plasticity', 'response to ischemia', 'synapse pruning']['aging', 'angiogenesis involved in wound healing', 'autocrine signaling', 'cell adhesion', 'cell chemotaxis', 'cell-cell adhesion', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'defense response', 'eosinophil chemotaxis', 'extrinsic apoptotic signaling pathway in absence of ligand', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'integrin activation', 'leukocyte adhesive activation', 'leukocyte chemotaxis', 'leukocyte migration involved in inflammatory response', 'lymphocyte chemotaxis', 'microglial cell activation', 'microglial cell proliferation', 'monocyte chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of apoptotic signaling pathway', 'negative regulation of cell migration', 'negative regulation of cell-substrate adhesion', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of glutamate receptor signaling pathway', 'negative regulation of hippocampal neuron apoptotic process', 'negative regulation of interleukin-1 alpha production', 'negative regulation of interleukin-1 beta production', 'negative regulation of interleukin-6 production', 'negative regulation of microglial cell activation', 'negative regulation of neuron migration', 'negative regulation of tumor necrosis factor production', 'neuron cellular homeostasis', 'neuron remodeling', 'neutrophil chemotaxis', 'positive chemotaxis', 'positive regulation of actin filament bundle assembly', 'positive regulation of calcium-independent cell-cell adhesion', 'positive regulation of cell population proliferation', 'positive regulation of cell-matrix adhesion', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of I-kappaB phosphorylation', 'positive regulation of inflammatory response', 'positive regulation of MAPK cascade', 'positive regulation of microglial cell migration', 'positive regulation of neuroblast proliferation', 'positive regulation of neuron projection development', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein kinase B signaling', 'positive regulation of release of sequestered calcium ion into cytosol', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transforming growth factor beta1 production', 'regulation of lipopolysaccharide-mediated signaling pathway', 'regulation of neurogenesis', 'regulation of synaptic plasticity', 'response to ischemia', 'synapse pruning']
Platelet factor 4
67
Platelet factor 4
27
8.4
75
0.16
P02777P02777['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'inflammatory response', 'leukocyte chemotaxis', 'negative regulation of angiogenesis', 'negative regulation of megakaryocyte differentiation', 'neutrophil chemotaxis', 'platelet activation', 'positive regulation of transcription by RNA polymerase II', 'regulation of cell population proliferation']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'inflammatory response', 'leukocyte chemotaxis', 'negative regulation of angiogenesis', 'negative regulation of megakaryocyte differentiation', 'neutrophil chemotaxis', 'platelet activation', 'positive regulation of transcription by RNA polymerase II', 'regulation of cell population proliferation']
Golgi reassembly-stacking protein 1
173
Golgin subfamily A member 2
984
7.9
56
0.23
Q9BQQ3Q08379['establishment of protein localization to plasma membrane', 'Golgi organization', 'negative regulation of dendrite morphogenesis', 'protein N-linked glycosylation', 'protein transport']['asymmetric cell division', 'centrosome cycle', 'endoplasmic reticulum to Golgi vesicle-mediated transport', 'Golgi disassembly', 'Golgi organization', 'Golgi ribbon formation', 'meiotic spindle assembly', 'microtubule nucleation', 'mitotic spindle assembly', 'negative regulation of autophagy', 'negative regulation of protein binding', 'positive regulation of protein glycosylation', 'protein glycosylation', 'protein homotetramerization', 'protein transport', 'spindle assembly']
Natural killer cells antigen CD94
70
NKG2-A/NKG2-B type II integral membrane protein
116
7.8
59
0.22
Q13241P26715['adaptive immune response', 'cell surface receptor signaling pathway', 'natural killer cell mediated immunity', 'negative regulation of natural killer cell mediated cytotoxicity', 'negative regulation of T cell mediated cytotoxicity', 'positive regulation of natural killer cell mediated cytotoxicity', 'regulation of natural killer cell activation', 'stimulatory C-type lectin receptor signaling pathway']['adaptive immune response', 'CD8-positive, gamma-delta intraepithelial T cell differentiation', 'cell surface receptor signaling pathway', 'innate immune response', 'natural killer cell inhibitory signaling pathway', 'negative regulation of natural killer cell mediated cytotoxicity', 'negative regulation of T cell mediated cytotoxicity', 'regulation of natural killer cell activation']
Acyloxyacyl hydrolase
40
Acyloxyacyl hydrolase
453
8.2
61
0.2
O18823O18823['fatty acid metabolic process', 'lipopolysaccharide catabolic process']['fatty acid metabolic process', 'lipopolysaccharide catabolic process']
RNA 5'-monophosphate methyltransferase
249
RNA 5'-monophosphate methyltransferase
248
6.5
80
0.19
Q7Z5W3Q7Z5W3['miRNA metabolic process', 'negative regulation of pre-miRNA processing', 'pre-miRNA processing', 'RNA methylation', 'tRNA methylation']['miRNA metabolic process', 'negative regulation of pre-miRNA processing', 'pre-miRNA processing', 'RNA methylation', 'tRNA methylation']
Caspase-4
105
Caspase-4
331
6.7
55
0.27
P70343P70343['actin filament organization', 'defense response to bacterium', 'defense response to Gram-positive bacterium', 'ectopic germ cell programmed cell death', 'inflammatory response', 'innate immune response', 'positive regulation of inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-18-mediated signaling pathway', 'positive regulation of macrophage cytokine production', 'protein autoprocessing', 'pyroptosis', 'regulation of apoptotic process', 'regulation of inflammatory response']['actin filament organization', 'defense response to bacterium', 'defense response to Gram-positive bacterium', 'ectopic germ cell programmed cell death', 'inflammatory response', 'innate immune response', 'positive regulation of inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-18-mediated signaling pathway', 'positive regulation of macrophage cytokine production', 'protein autoprocessing', 'pyroptosis', 'regulation of apoptotic process', 'regulation of inflammatory response']
Mothers against decapentaplegic homolog 2
463
Mothers against decapentaplegic homolog 4
523
8.4
71
0.17
Q15796Q13485['activin receptor signaling pathway', 'adrenal gland development', 'anatomical structure morphogenesis', 'anterior/posterior pattern specification', 'BMP signaling pathway', 'cell differentiation', 'cell fate commitment', 'common-partner SMAD protein phosphorylation', 'embryonic cranial skeleton morphogenesis', 'embryonic foregut morphogenesis', 'endoderm formation', 'gastrulation', 'in utero embryonic development', 'insulin secretion', 'intracellular signal transduction', 'lung development', 'mesoderm formation', 'negative regulation of cell population proliferation', 'negative regulation of transcription, DNA-templated', 'nodal signaling pathway', 'organ growth', 'pancreas development', 'paraxial mesoderm morphogenesis', 'pericardium development', 'positive regulation of BMP signaling pathway', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of gene expression', 'positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'post-embryonic development', 'primary miRNA processing', 'regulation of binding', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to glucose', 'secondary palate development', 'signal transduction involved in regulation of gene expression', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transcription, DNA-templated', 'transforming growth factor beta receptor signaling pathway', 'ureteric bud development', 'wound healing', 'zygotic specification of dorsal/ventral axis']['activin receptor signaling pathway', 'adrenal gland development', 'aging', 'anatomical structure morphogenesis', 'atrioventricular canal development', 'atrioventricular valve formation', 'axon guidance', 'BMP signaling pathway', 'brainstem development', 'branching involved in ureteric bud morphogenesis', 'cardiac conduction system development', 'cell differentiation', 'cell population proliferation', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'cellular response to glucose stimulus', 'developmental growth', 'embryonic digit morphogenesis', 'endocardial cell differentiation', 'endothelial cell activation', 'epithelial to mesenchymal transition involved in endocardial cushion formation', 'ERK1 and ERK2 cascade', 'female gonad morphogenesis', 'formation of anatomical boundary', 'gastrulation with mouth forming second', 'in utero embryonic development', 'interleukin-6-mediated signaling pathway', 'intracellular signal transduction', 'left ventricular cardiac muscle tissue morphogenesis', 'mesendoderm development', 'metanephric mesenchyme morphogenesis', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of cardiac myofibril assembly', 'negative regulation of cell death', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of protein catabolic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'nephrogenic mesenchyme morphogenesis', 'neural crest cell differentiation', 'neuron fate commitment', 'osteoblast differentiation', 'outflow tract septum morphogenesis', 'ovarian follicle development', 'positive regulation of BMP signaling pathway', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of cell proliferation involved in heart valve morphogenesis', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of follicle-stimulating hormone secretion', 'positive regulation of histone H3-K4 methylation', 'positive regulation of histone H3-K9 acetylation', 'positive regulation of luteinizing hormone secretion', 'positive regulation of miRNA transcription', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta receptor signaling pathway', 'regulation of binding', 'regulation of hair follicle development', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to transforming growth factor beta', 'sebaceous gland development', 'secondary palate development', 'seminiferous tubule development', 'single fertilization', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'somite rostral/caudal axis specification', 'spermatogenesis', 'transcription by RNA polymerase II', 'transcription, DNA-templated', 'transforming growth factor beta receptor signaling pathway', 'uterus development', 'ventricular septum morphogenesis', 'wound healing']
Neutrophil defensin 1
68
Neutrophil defensin 1
73
8.0
73
0.17
P59665P59665['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']
Glutamate receptor 2
78
Glutamate receptor 4
331
8.0
74
0.17
P19491P19493['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']['chemical synaptic transmission', 'modulation of chemical synaptic transmission', 'negative regulation of smooth muscle cell apoptotic process', 'positive regulation of synaptic transmission, glutamatergic', 'regulation of synapse structure or activity', 'response to fungicide']
Platelet factor 4
67
Platelet factor 4
67
8.1
76
0.16
P02777P02777['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'inflammatory response', 'leukocyte chemotaxis', 'negative regulation of angiogenesis', 'negative regulation of megakaryocyte differentiation', 'neutrophil chemotaxis', 'platelet activation', 'positive regulation of transcription by RNA polymerase II', 'regulation of cell population proliferation']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'inflammatory response', 'leukocyte chemotaxis', 'negative regulation of angiogenesis', 'negative regulation of megakaryocyte differentiation', 'neutrophil chemotaxis', 'platelet activation', 'positive regulation of transcription by RNA polymerase II', 'regulation of cell population proliferation']
PRKCA-binding protein
46
PRKCA-binding protein
46
8.2
76
0.16
Q9NRD5Q9NRD5['cellular response to decreased oxygen levels', 'cellular response to glucose starvation', 'dendritic spine maintenance', 'dendritic spine organization', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'glial cell development', 'intracellular protein transport', 'long-term synaptic depression', 'monoamine transport', 'negative regulation of Arp2/3 complex-mediated actin nucleation', 'neuronal ion channel clustering', 'positive regulation of receptor internalization', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'receptor clustering', 'regulation of Arp2/3 complex-mediated actin nucleation', 'regulation of insulin secretion', 'retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum']['cellular response to decreased oxygen levels', 'cellular response to glucose starvation', 'dendritic spine maintenance', 'dendritic spine organization', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'glial cell development', 'intracellular protein transport', 'long-term synaptic depression', 'monoamine transport', 'negative regulation of Arp2/3 complex-mediated actin nucleation', 'neuronal ion channel clustering', 'positive regulation of receptor internalization', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'receptor clustering', 'regulation of Arp2/3 complex-mediated actin nucleation', 'regulation of insulin secretion', 'retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum']
NKG2-D type II integral membrane protein
121
NKG2-D type II integral membrane protein
112
6.2
83
0.19
O54709O54709['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of apoptotic process', 'positive regulation of interferon-gamma production', 'positive regulation of myeloid dendritic cell activation', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target', 'positive regulation of nitric oxide biosynthetic process', 'stimulatory C-type lectin receptor signaling pathway']['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of apoptotic process', 'positive regulation of interferon-gamma production', 'positive regulation of myeloid dendritic cell activation', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target', 'positive regulation of nitric oxide biosynthetic process', 'stimulatory C-type lectin receptor signaling pathway']
Defensin alpha 4
82
Defensin alpha 4
82
6.5
77
0.2
P12838P12838['antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'antimicrobial humoral response', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism', 'T cell chemotaxis']['antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'antimicrobial humoral response', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism', 'T cell chemotaxis']
Fractalkine
36
Fractalkine
32
9.0
61
0.18
P78423P78423['aging', 'angiogenesis involved in wound healing', 'autocrine signaling', 'cell adhesion', 'cell chemotaxis', 'cell-cell adhesion', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'defense response', 'eosinophil chemotaxis', 'extrinsic apoptotic signaling pathway in absence of ligand', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'integrin activation', 'leukocyte adhesive activation', 'leukocyte chemotaxis', 'leukocyte migration involved in inflammatory response', 'lymphocyte chemotaxis', 'microglial cell activation', 'microglial cell proliferation', 'monocyte chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of apoptotic signaling pathway', 'negative regulation of cell migration', 'negative regulation of cell-substrate adhesion', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of glutamate receptor signaling pathway', 'negative regulation of hippocampal neuron apoptotic process', 'negative regulation of interleukin-1 alpha production', 'negative regulation of interleukin-1 beta production', 'negative regulation of interleukin-6 production', 'negative regulation of microglial cell activation', 'negative regulation of neuron migration', 'negative regulation of tumor necrosis factor production', 'neuron cellular homeostasis', 'neuron remodeling', 'neutrophil chemotaxis', 'positive chemotaxis', 'positive regulation of actin filament bundle assembly', 'positive regulation of calcium-independent cell-cell adhesion', 'positive regulation of cell population proliferation', 'positive regulation of cell-matrix adhesion', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of I-kappaB phosphorylation', 'positive regulation of inflammatory response', 'positive regulation of MAPK cascade', 'positive regulation of microglial cell migration', 'positive regulation of neuroblast proliferation', 'positive regulation of neuron projection development', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein kinase B signaling', 'positive regulation of release of sequestered calcium ion into cytosol', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transforming growth factor beta1 production', 'regulation of lipopolysaccharide-mediated signaling pathway', 'regulation of neurogenesis', 'regulation of synaptic plasticity', 'response to ischemia', 'synapse pruning']['aging', 'angiogenesis involved in wound healing', 'autocrine signaling', 'cell adhesion', 'cell chemotaxis', 'cell-cell adhesion', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'defense response', 'eosinophil chemotaxis', 'extrinsic apoptotic signaling pathway in absence of ligand', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'integrin activation', 'leukocyte adhesive activation', 'leukocyte chemotaxis', 'leukocyte migration involved in inflammatory response', 'lymphocyte chemotaxis', 'microglial cell activation', 'microglial cell proliferation', 'monocyte chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of apoptotic signaling pathway', 'negative regulation of cell migration', 'negative regulation of cell-substrate adhesion', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of glutamate receptor signaling pathway', 'negative regulation of hippocampal neuron apoptotic process', 'negative regulation of interleukin-1 alpha production', 'negative regulation of interleukin-1 beta production', 'negative regulation of interleukin-6 production', 'negative regulation of microglial cell activation', 'negative regulation of neuron migration', 'negative regulation of tumor necrosis factor production', 'neuron cellular homeostasis', 'neuron remodeling', 'neutrophil chemotaxis', 'positive chemotaxis', 'positive regulation of actin filament bundle assembly', 'positive regulation of calcium-independent cell-cell adhesion', 'positive regulation of cell population proliferation', 'positive regulation of cell-matrix adhesion', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of I-kappaB phosphorylation', 'positive regulation of inflammatory response', 'positive regulation of MAPK cascade', 'positive regulation of microglial cell migration', 'positive regulation of neuroblast proliferation', 'positive regulation of neuron projection development', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein kinase B signaling', 'positive regulation of release of sequestered calcium ion into cytosol', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transforming growth factor beta1 production', 'regulation of lipopolysaccharide-mediated signaling pathway', 'regulation of neurogenesis', 'regulation of synaptic plasticity', 'response to ischemia', 'synapse pruning']
Nitric oxide synthase, endothelial
96
Nitric oxide synthase, endothelial
96
4.7
65
0.33
P29473P29473['arginine catabolic process', 'blood coagulation', 'cellular response to laminar fluid shear stress', 'mitochondrion organization', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of leukocyte cell-cell adhesion', 'nitric oxide biosynthetic process', 'positive regulation of guanylate cyclase activity']['arginine catabolic process', 'blood coagulation', 'cellular response to laminar fluid shear stress', 'mitochondrion organization', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of leukocyte cell-cell adhesion', 'nitric oxide biosynthetic process', 'positive regulation of guanylate cyclase activity']
RNA 5'-monophosphate methyltransferase
249
RNA 5'-monophosphate methyltransferase
249
4.7
80
0.27
Q7Z5W3Q7Z5W3['miRNA metabolic process', 'negative regulation of pre-miRNA processing', 'pre-miRNA processing', 'RNA methylation', 'tRNA methylation']['miRNA metabolic process', 'negative regulation of pre-miRNA processing', 'pre-miRNA processing', 'RNA methylation', 'tRNA methylation']
Histone H3.1
111
Histone H3.1
111
6.2
82
0.2
P68431P68431['DNA replication-dependent chromatin assembly', 'nucleosome assembly', 'regulation of gene expression, epigenetic', 'telomere organization']['DNA replication-dependent chromatin assembly', 'nucleosome assembly', 'regulation of gene expression, epigenetic', 'telomere organization']
General transcription factor IIH subunit 3
142
General transcription factor IIH subunit 2
348
6.5
84
0.18
Q13889Q13888['DNA repair', 'nucleotide-excision repair', 'phosphorylation of RNA polymerase II C-terminal domain', 'transcription by RNA polymerase II']['G protein-coupled receptor internalization', 'nucleotide-excision repair', 'positive regulation of DNA helicase activity', 'regulation of transcription by RNA polymerase II', 'response to UV', 'transcription by RNA polymerase II', 'transcription initiation from RNA polymerase II promoter']
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
172
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
172
6.5
nan
nan
Q9Y223Q9Y223['cell adhesion', 'N-acetylglucosamine biosynthetic process', 'N-acetylneuraminate metabolic process', 'UDP-N-acetylglucosamine metabolic process']['cell adhesion', 'N-acetylglucosamine biosynthetic process', 'N-acetylneuraminate metabolic process', 'UDP-N-acetylglucosamine metabolic process']
Bone marrow stromal antigen 2
63
Bone marrow stromal antigen 2
63
6.5
78
0.2
Q10589Q10589['B cell activation', 'defense response to virus', 'innate immune response', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of intracellular transport of viral material', 'negative regulation of plasmacytoid dendritic cell cytokine production', 'negative regulation of viral genome replication', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of leukocyte proliferation', 'regulation of actin cytoskeleton organization', 'response to interferon-alpha', 'response to interferon-beta', 'response to interferon-gamma', 'response to virus']['B cell activation', 'defense response to virus', 'innate immune response', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of intracellular transport of viral material', 'negative regulation of plasmacytoid dendritic cell cytokine production', 'negative regulation of viral genome replication', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of leukocyte proliferation', 'regulation of actin cytoskeleton organization', 'response to interferon-alpha', 'response to interferon-beta', 'response to interferon-gamma', 'response to virus']
Defensin-6
99
Defensin-6
99
6.5
64
0.24
Q01524Q01524['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism']
C-C motif chemokine 3
57
C-C motif chemokine 3
33
6.1
64
0.26
P10147P10147['astrocyte cell migration', 'calcium ion transport', 'calcium-mediated signaling', 'cell activation', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytoskeleton organization', 'eosinophil chemotaxis', 'eosinophil degranulation', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'granulocyte chemotaxis', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'negative regulation of osteoclast differentiation', 'neutrophil chemotaxis', 'osteoblast differentiation', 'positive regulation of calcium ion import', 'positive regulation of calcium ion transport', 'positive regulation of calcium-mediated signaling', 'positive regulation of cell migration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of GTPase activity', 'positive regulation of inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of microglial cell activation', 'positive regulation of microglial cell migration', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of protein kinase B signaling', 'positive regulation of tumor necrosis factor production', 'protein kinase B signaling', 'regulation of behavior', 'regulation of cell shape', 'regulation of sensory perception of pain', 'release of sequestered calcium ion into cytosol by sarcoplasmic reticulum', 'response to cholesterol', 'response to toxic substance', 'signaling', 'T cell chemotaxis']['astrocyte cell migration', 'calcium ion transport', 'calcium-mediated signaling', 'cell activation', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytoskeleton organization', 'eosinophil chemotaxis', 'eosinophil degranulation', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'granulocyte chemotaxis', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'negative regulation of osteoclast differentiation', 'neutrophil chemotaxis', 'osteoblast differentiation', 'positive regulation of calcium ion import', 'positive regulation of calcium ion transport', 'positive regulation of calcium-mediated signaling', 'positive regulation of cell migration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of GTPase activity', 'positive regulation of inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of microglial cell activation', 'positive regulation of microglial cell migration', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of protein kinase B signaling', 'positive regulation of tumor necrosis factor production', 'protein kinase B signaling', 'regulation of behavior', 'regulation of cell shape', 'regulation of sensory perception of pain', 'release of sequestered calcium ion into cytosol by sarcoplasmic reticulum', 'response to cholesterol', 'response to toxic substance', 'signaling', 'T cell chemotaxis']
RNA 5'-monophosphate methyltransferase
248
RNA 5'-monophosphate methyltransferase
248
8.7
77
0.15
Q7Z5W3Q7Z5W3['miRNA metabolic process', 'negative regulation of pre-miRNA processing', 'pre-miRNA processing', 'RNA methylation', 'tRNA methylation']['miRNA metabolic process', 'negative regulation of pre-miRNA processing', 'pre-miRNA processing', 'RNA methylation', 'tRNA methylation']
Fibrinogen gamma chain
35
Fibrinogen gamma chain
35
6.0
49
0.34
P02679P02679['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
Cartilage oligomeric matrix protein
68
Cartilage oligomeric matrix protein
68
6.0
51
0.33
P35444P35444['apoptotic process', 'artery morphogenesis', 'blood coagulation', 'BMP signaling pathway', 'bone growth', 'bone mineralization', 'bone morphogenesis', 'cartilage development', 'cartilage homeostasis', 'chondrocyte development', 'chondrocyte proliferation', 'collagen fibril organization', 'endochondral bone growth', 'growth plate cartilage development', 'limb development', 'multicellular organism aging', 'multicellular organism growth', 'muscle cell development', 'musculoskeletal movement', 'negative regulation of apoptotic process', 'negative regulation of hemostasis', 'neuromuscular process', 'ossification', 'platelet aggregation', 'positive regulation of chondrocyte proliferation', 'protein homooligomerization', 'protein processing', 'protein secretion', 'regulation of bone mineralization', 'regulation of gene expression', 'response to unfolded protein', 'skeletal system development', 'skin development', 'tendon development', 'vascular associated smooth muscle cell development', 'vascular associated smooth muscle contraction']['apoptotic process', 'artery morphogenesis', 'blood coagulation', 'BMP signaling pathway', 'bone growth', 'bone mineralization', 'bone morphogenesis', 'cartilage development', 'cartilage homeostasis', 'chondrocyte development', 'chondrocyte proliferation', 'collagen fibril organization', 'endochondral bone growth', 'growth plate cartilage development', 'limb development', 'multicellular organism aging', 'multicellular organism growth', 'muscle cell development', 'musculoskeletal movement', 'negative regulation of apoptotic process', 'negative regulation of hemostasis', 'neuromuscular process', 'ossification', 'platelet aggregation', 'positive regulation of chondrocyte proliferation', 'protein homooligomerization', 'protein processing', 'protein secretion', 'regulation of bone mineralization', 'regulation of gene expression', 'response to unfolded protein', 'skeletal system development', 'skin development', 'tendon development', 'vascular associated smooth muscle cell development', 'vascular associated smooth muscle contraction']
Cyanocobalamin reductase / alkylcobalamin dealkylase
70
Cyanocobalamin reductase / alkylcobalamin dealkylase
70
6.1
42
0.39
Q9Y4U1Q9Y4U1['cobalamin metabolic process', 'demethylation', 'glutathione metabolic process']['cobalamin metabolic process', 'demethylation', 'glutathione metabolic process']
cAMP-dependent protein kinase type II-beta regulatory subunit
114
cAMP-dependent protein kinase catalytic subunit alpha
200
4.9
68
0.3
P31324P05132['fatty acid metabolic process', 'learning', 'modulation of chemical synaptic transmission', 'negative regulation of cAMP-dependent protein kinase activity', 'regulation of protein kinase activity', 'response to antipsychotic drug', 'response to clozapine']['cellular response to cold', 'cellular response to glucose stimulus', 'cellular response to heat', 'cellular response to parathyroid hormone stimulus', 'mesoderm formation', 'modulation of chemical synaptic transmission', 'mRNA processing', 'negative regulation of meiotic cell cycle', 'negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning', 'neural tube closure', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of cell population proliferation', 'positive regulation of protein export from nucleus', 'protein autophosphorylation', 'protein export from nucleus', 'protein kinase A signaling', 'protein localization to lipid droplet', 'protein phosphorylation', 'regulation of bicellular tight junction assembly', 'regulation of cell cycle', 'regulation of cellular respiration', 'regulation of osteoblast differentiation', 'regulation of proteasomal protein catabolic process', 'regulation of protein processing', 'regulation of synaptic transmission, glutamatergic', 'sperm capacitation', 'spontaneous exocytosis of neurotransmitter']
Translation initiation factor eIF-2B subunit alpha
218
Translation initiation factor eIF-2B subunit alpha
218
5.1
77
0.25
Q14232Q14232['oligodendrocyte development', 'regulation of catalytic activity', 'response to glucose', 'response to heat', 'response to peptide hormone', 'T cell receptor signaling pathway', 'translational initiation']['oligodendrocyte development', 'regulation of catalytic activity', 'response to glucose', 'response to heat', 'response to peptide hormone', 'T cell receptor signaling pathway', 'translational initiation']
Caspase-2
179
Caspase-2
399
5.2
53
0.36
P42575P42575['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'aging', 'apoptotic process', 'apoptotic signaling pathway', 'brain development', 'cellular response to DNA damage stimulus', 'cellular response to mechanical stimulus', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'ectopic germ cell programmed cell death', 'execution phase of apoptosis', 'extrinsic apoptotic signaling pathway in absence of ligand', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'luteolysis', 'negative regulation of apoptotic process', 'negative regulation of necroptotic process', 'neural retina development', 'positive regulation of apoptotic process', 'positive regulation of apoptotic signaling pathway', 'positive regulation of neuron apoptotic process', 'protein processing', 'release of cytochrome c from mitochondria']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'aging', 'apoptotic process', 'apoptotic signaling pathway', 'brain development', 'cellular response to DNA damage stimulus', 'cellular response to mechanical stimulus', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'ectopic germ cell programmed cell death', 'execution phase of apoptosis', 'extrinsic apoptotic signaling pathway in absence of ligand', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'luteolysis', 'negative regulation of apoptotic process', 'negative regulation of necroptotic process', 'neural retina development', 'positive regulation of apoptotic process', 'positive regulation of apoptotic signaling pathway', 'positive regulation of neuron apoptotic process', 'protein processing', 'release of cytochrome c from mitochondria']
Geminin coiled-coil domain-containing protein 1
122
Geminin coiled-coil domain-containing protein 1
122
5.4
41
0.45
A6NCL1A6NCL1['cell cycle', 'cilium assembly', 'DNA replication initiation', 'negative regulation of cell cycle', 'negative regulation of DNA replication']['cell cycle', 'cilium assembly', 'DNA replication initiation', 'negative regulation of cell cycle', 'negative regulation of DNA replication']
Hepatocyte growth factor
129
Hepatocyte growth factor
207
4.4
70
0.33
Q08048Q08048['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'proteolysis', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'proteolysis', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']
Platelet factor 4
27
Platelet factor 4
27
8.9
75
0.15
P02777P02777['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'inflammatory response', 'leukocyte chemotaxis', 'negative regulation of angiogenesis', 'negative regulation of megakaryocyte differentiation', 'neutrophil chemotaxis', 'platelet activation', 'positive regulation of transcription by RNA polymerase II', 'regulation of cell population proliferation']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'inflammatory response', 'leukocyte chemotaxis', 'negative regulation of angiogenesis', 'negative regulation of megakaryocyte differentiation', 'neutrophil chemotaxis', 'platelet activation', 'positive regulation of transcription by RNA polymerase II', 'regulation of cell population proliferation']
cAMP-dependent protein kinase
200
cAMP-dependent protein kinase type II-beta regulatory subunit
114
4.8
68
0.3
A1L1M0P31324['protein phosphorylation']['fatty acid metabolic process', 'learning', 'modulation of chemical synaptic transmission', 'negative regulation of cAMP-dependent protein kinase activity', 'regulation of protein kinase activity', 'response to antipsychotic drug', 'response to clozapine']
Protein bicaudal D homolog 1
752
Protein bicaudal D homolog 1
752
4.8
46
0.45
Q8BR07Q8BR07['microtubule anchoring at microtubule organizing center', 'minus-end-directed organelle transport along microtubule', 'negative regulation of phospholipase C activity', 'negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to centrosome', 'positive regulation of receptor-mediated endocytosis', 'protein localization to organelle', 'regulation of microtubule cytoskeleton organization', 'regulation of proteinase activated receptor activity', 'stress granule assembly', 'viral process']['microtubule anchoring at microtubule organizing center', 'minus-end-directed organelle transport along microtubule', 'negative regulation of phospholipase C activity', 'negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to centrosome', 'positive regulation of receptor-mediated endocytosis', 'protein localization to organelle', 'regulation of microtubule cytoskeleton organization', 'regulation of proteinase activated receptor activity', 'stress granule assembly', 'viral process']
Kinesin light chain 2
221
Kinesin light chain 2
221
6.5
77
0.2
Q9H0B6Q9H0B6['lysosome localization', 'microtubule-based movement']['lysosome localization', 'microtubule-based movement']
E3 ubiquitin-protein ligase RNF169
626
E3 ubiquitin-protein ligase RNF169
626
3.7
59
0.46
Q8NCN4Q8NCN4['cellular response to DNA damage stimulus', 'double-strand break repair', 'negative regulation of double-strand break repair']['cellular response to DNA damage stimulus', 'double-strand break repair', 'negative regulation of double-strand break repair']
Serine/threonine-protein kinase VRK1
220
Serine/threonine-protein kinase VRK1
220
3.7
82
0.33
Q99986Q99986['cell division', 'cellular response to DNA damage stimulus', 'Golgi disassembly', 'histone phosphorylation', 'mitotic nuclear membrane disassembly', 'peptidyl-serine phosphorylation', 'positive regulation of protein localization to chromatin', 'protein autophosphorylation', 'protein phosphorylation', 'signal transduction']['cell division', 'cellular response to DNA damage stimulus', 'Golgi disassembly', 'histone phosphorylation', 'mitotic nuclear membrane disassembly', 'peptidyl-serine phosphorylation', 'positive regulation of protein localization to chromatin', 'protein autophosphorylation', 'protein phosphorylation', 'signal transduction']
S-adenosylmethionine decarboxylase proenzyme
148
S-adenosylmethionine decarboxylase proenzyme
148
6.6
79
0.19
P17707P17707['polyamine metabolic process', 'S-adenosylmethioninamine biosynthetic process', 'S-adenosylmethionine metabolic process', 'spermidine biosynthetic process', 'spermine biosynthetic process']['polyamine metabolic process', 'S-adenosylmethioninamine biosynthetic process', 'S-adenosylmethionine metabolic process', 'spermidine biosynthetic process', 'spermine biosynthetic process']
Natural killer cells antigen CD94
72
NKG2-A/NKG2-B type II integral membrane protein
116
8.6
65
0.18
Q13241P26715['adaptive immune response', 'cell surface receptor signaling pathway', 'natural killer cell mediated immunity', 'negative regulation of natural killer cell mediated cytotoxicity', 'negative regulation of T cell mediated cytotoxicity', 'positive regulation of natural killer cell mediated cytotoxicity', 'regulation of natural killer cell activation', 'stimulatory C-type lectin receptor signaling pathway']['adaptive immune response', 'CD8-positive, gamma-delta intraepithelial T cell differentiation', 'cell surface receptor signaling pathway', 'innate immune response', 'natural killer cell inhibitory signaling pathway', 'negative regulation of natural killer cell mediated cytotoxicity', 'negative regulation of T cell mediated cytotoxicity', 'regulation of natural killer cell activation']
Platelet factor 4
83
Platelet factor 4
83
8.6
75
0.16
P02776P02776['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'defense response to protozoan', 'inflammatory response', 'killing by host of symbiont cells', 'killing of cells of another organism', 'leukocyte chemotaxis', 'negative regulation of angiogenesis', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of megakaryocyte differentiation', 'negative regulation of MHC class II biosynthetic process', 'neutrophil chemotaxis', 'platelet activation', 'positive regulation of gene expression', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of macrophage differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'regulation of cell population proliferation']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'defense response to protozoan', 'inflammatory response', 'killing by host of symbiont cells', 'killing of cells of another organism', 'leukocyte chemotaxis', 'negative regulation of angiogenesis', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of megakaryocyte differentiation', 'negative regulation of MHC class II biosynthetic process', 'neutrophil chemotaxis', 'platelet activation', 'positive regulation of gene expression', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of macrophage differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'regulation of cell population proliferation']
Early activation antigen CD69
85
Early activation antigen CD69
85
8.6
67
0.17
Q07108Q07108['cellular response to xenobiotic stimulus']['cellular response to xenobiotic stimulus']
C-type lectin domain family 4 member D
83
C-type lectin domain family 4 member D
83
6.9
82
0.18
Q8WXI8Q8WXI8['adaptive immune response', 'antifungal innate immune response', 'defense response to bacterium', 'Fc-gamma receptor signaling pathway', 'immune response', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of myeloid dendritic cell activation', 'T cell differentiation involved in immune response']['adaptive immune response', 'antifungal innate immune response', 'defense response to bacterium', 'Fc-gamma receptor signaling pathway', 'immune response', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of myeloid dendritic cell activation', 'T cell differentiation involved in immune response']
Prostaglandin-H2 D-isomerase
186
Prostaglandin-H2 D-isomerase
89
8.6
67
0.17
P41222P41222['cyclooxygenase pathway', 'gene expression', 'mast cell degranulation', 'negative regulation of male germ cell proliferation', 'prostaglandin biosynthetic process', 'regulation of circadian sleep/wake cycle, sleep', 'response to glucocorticoid']['cyclooxygenase pathway', 'gene expression', 'mast cell degranulation', 'negative regulation of male germ cell proliferation', 'prostaglandin biosynthetic process', 'regulation of circadian sleep/wake cycle, sleep', 'response to glucocorticoid']
Seminal ribonuclease
57
Seminal ribonuclease
57
7.1
69
0.2
P00669P00669['defense response to Gram-positive bacterium', 'RNA phosphodiester bond hydrolysis']['defense response to Gram-positive bacterium', 'RNA phosphodiester bond hydrolysis']
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
414
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
414
7.3
66
0.21
Q9Y233Q9Y233['cAMP catabolic process', 'cGMP catabolic process', 'negative regulation of cGMP-mediated signaling', 'signal transduction']['cAMP catabolic process', 'cGMP catabolic process', 'negative regulation of cGMP-mediated signaling', 'signal transduction']
PRSS3 protein
68
Amyloid-beta A4 protein
222
8.5
95
0.12
Q8N2U3H7C0V9['proteolysis']['nervous system development']
Mothers against decapentaplegic homolog 3
421
Mothers against decapentaplegic homolog 4
523
8.5
68
0.17
P84022Q13485['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'activin receptor signaling pathway', 'adrenal gland development', 'anatomical structure morphogenesis', 'BMP signaling pathway', 'cell differentiation', 'cell-cell junction organization', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'developmental growth', 'embryonic cranial skeleton morphogenesis', 'embryonic foregut morphogenesis', 'embryonic pattern specification', 'endoderm development', 'extrinsic apoptotic signaling pathway', 'heart looping', 'immune response', 'immune system development', 'in utero embryonic development', 'JNK cascade', 'lens fiber cell differentiation', 'liver development', 'mesoderm formation', 'negative regulation of apoptotic process', 'negative regulation of cardiac muscle hypertrophy in response to stress', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cytosolic calcium ion concentration', 'negative regulation of fat cell differentiation', 'negative regulation of inflammatory response', 'negative regulation of lung blood pressure', 'negative regulation of osteoblast differentiation', 'negative regulation of osteoblast proliferation', 'negative regulation of protein catabolic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of wound healing', 'nodal signaling pathway', 'osteoblast development', 'paraxial mesoderm morphogenesis', 'pericardium development', 'positive regulation of alkaline phosphatase activity', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cell migration', 'positive regulation of chondrocyte differentiation', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of extracellular matrix assembly', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of interleukin-1 beta production', 'positive regulation of miRNA transcription', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of positive chemotaxis', 'positive regulation of protein import into nucleus', 'positive regulation of stress fiber assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta3 production', 'primary miRNA processing', 'protein stabilization', 'regulation of binding', 'regulation of epithelial cell proliferation', 'regulation of immune response', 'regulation of miRNA transcription', 'regulation of striated muscle tissue development', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'signal transduction involved in regulation of gene expression', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'somitogenesis', 'T cell activation', 'thyroid gland development', 'transdifferentiation', 'transforming growth factor beta receptor signaling pathway', 'ureteric bud development', 'wound healing']['activin receptor signaling pathway', 'adrenal gland development', 'aging', 'anatomical structure morphogenesis', 'atrioventricular canal development', 'atrioventricular valve formation', 'axon guidance', 'BMP signaling pathway', 'brainstem development', 'branching involved in ureteric bud morphogenesis', 'cardiac conduction system development', 'cell differentiation', 'cell population proliferation', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'cellular response to glucose stimulus', 'developmental growth', 'embryonic digit morphogenesis', 'endocardial cell differentiation', 'endothelial cell activation', 'epithelial to mesenchymal transition involved in endocardial cushion formation', 'ERK1 and ERK2 cascade', 'female gonad morphogenesis', 'formation of anatomical boundary', 'gastrulation with mouth forming second', 'in utero embryonic development', 'interleukin-6-mediated signaling pathway', 'intracellular signal transduction', 'left ventricular cardiac muscle tissue morphogenesis', 'mesendoderm development', 'metanephric mesenchyme morphogenesis', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of cardiac myofibril assembly', 'negative regulation of cell death', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of protein catabolic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'nephrogenic mesenchyme morphogenesis', 'neural crest cell differentiation', 'neuron fate commitment', 'osteoblast differentiation', 'outflow tract septum morphogenesis', 'ovarian follicle development', 'positive regulation of BMP signaling pathway', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of cell proliferation involved in heart valve morphogenesis', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of follicle-stimulating hormone secretion', 'positive regulation of histone H3-K4 methylation', 'positive regulation of histone H3-K9 acetylation', 'positive regulation of luteinizing hormone secretion', 'positive regulation of miRNA transcription', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta receptor signaling pathway', 'regulation of binding', 'regulation of hair follicle development', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to transforming growth factor beta', 'sebaceous gland development', 'secondary palate development', 'seminiferous tubule development', 'single fertilization', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'somite rostral/caudal axis specification', 'spermatogenesis', 'transcription by RNA polymerase II', 'transcription, DNA-templated', 'transforming growth factor beta receptor signaling pathway', 'uterus development', 'ventricular septum morphogenesis', 'wound healing']
Seminal ribonuclease
58
Seminal ribonuclease
58
7.3
59
0.23
P00669P00669['defense response to Gram-positive bacterium', 'RNA phosphodiester bond hydrolysis']['defense response to Gram-positive bacterium', 'RNA phosphodiester bond hydrolysis']
Nuclear transport factor 2
80
Nuclear transport factor 2
80
7.3
67
0.21
P61972P61972['mRNA transport', 'negative regulation of vascular endothelial growth factor production', 'nucleocytoplasmic transport', 'positive regulation of protein import into nucleus', 'protein export from nucleus', 'protein import into nucleus', 'protein localization to nuclear pore']['mRNA transport', 'negative regulation of vascular endothelial growth factor production', 'nucleocytoplasmic transport', 'positive regulation of protein import into nucleus', 'protein export from nucleus', 'protein import into nucleus', 'protein localization to nuclear pore']
Glutamate receptor 3
334
Glutamate receptor 3
334
8.4
73
0.16
P19492P19492['regulation of receptor recycling', 'response to fungicide', 'response to lithium ion']['regulation of receptor recycling', 'response to fungicide', 'response to lithium ion']
Ubiquitin-conjugating enzyme E2 R1
93
Ubiquitin-conjugating enzyme E2 R1
93
8.4
79
0.15
P49427P49427['cellular response to interferon-beta', 'DNA replication initiation', 'G1/S transition of mitotic cell cycle', 'negative regulation of cAMP-mediated signaling', 'positive regulation of inclusion body assembly', 'positive regulation of neuron apoptotic process', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein K48-linked ubiquitination', 'protein modification process', 'protein polyubiquitination', 'protein ubiquitination', 'response to growth factor', 'ubiquitin-dependent protein catabolic process']['cellular response to interferon-beta', 'DNA replication initiation', 'G1/S transition of mitotic cell cycle', 'negative regulation of cAMP-mediated signaling', 'positive regulation of inclusion body assembly', 'positive regulation of neuron apoptotic process', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein K48-linked ubiquitination', 'protein modification process', 'protein polyubiquitination', 'protein ubiquitination', 'response to growth factor', 'ubiquitin-dependent protein catabolic process']
Chymotrypsinogen A
191
Serine protease inhibitor Kazal-type 1
39
9.8
100
0.1
P00766P00995['digestion', 'proteolysis']['cellular response to peptide hormone stimulus', 'negative regulation of calcium ion import', 'negative regulation of nitric oxide mediated signal transduction', 'negative regulation of peptidyl-tyrosine phosphorylation', 'negative regulation of serine-type endopeptidase activity', 'nitric oxide mediated signal transduction', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of epithelial cell proliferation', 'positive regulation of pancreatic juice secretion', 'positive regulation of peptide hormone secretion', 'regulation of acrosome reaction', 'regulation of store-operated calcium entry', 'response to ethanol', 'response to nutrient levels', 'sperm capacitation']
Protein FAM3C
221
Protein FAM3C
58
9.5
62
0.17
Q91VU0Q91VU0['negative regulation of gluconeogenesis']['negative regulation of gluconeogenesis']
Thioredoxin-interacting protein
333
Thioredoxin-interacting protein
333
2.0
63
0.77
Q9H3M7Q9H3M7['cell cycle', 'cellular response to tumor cell', 'keratinocyte differentiation', 'negative regulation of cell division', 'negative regulation of transcription by RNA polymerase II', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of apoptotic process', 'protein import into nucleus', 'protein transport', 'regulation of cell population proliferation', 'response to calcium ion', 'response to estradiol', 'response to glucose', 'response to hydrogen peroxide', 'response to mechanical stimulus', 'response to progesterone', 'response to xenobiotic stimulus']['cell cycle', 'cellular response to tumor cell', 'keratinocyte differentiation', 'negative regulation of cell division', 'negative regulation of transcription by RNA polymerase II', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of apoptotic process', 'protein import into nucleus', 'protein transport', 'regulation of cell population proliferation', 'response to calcium ion', 'response to estradiol', 'response to glucose', 'response to hydrogen peroxide', 'response to mechanical stimulus', 'response to progesterone', 'response to xenobiotic stimulus']
Ceramidase
31
Ceramidase
340
2.0
63
0.78
A8K0B6A8K0B6['fatty acid metabolic process']['fatty acid metabolic process']
ATP-citrate synthase
293
ATP-citrate synthase
748
2.0
56
0.87
P53396P53396['acetyl-CoA biosynthetic process', 'cholesterol biosynthetic process', 'citrate metabolic process', 'coenzyme A metabolic process', 'fatty acid biosynthetic process', 'lipid biosynthetic process', 'oxaloacetate metabolic process']['acetyl-CoA biosynthetic process', 'cholesterol biosynthetic process', 'citrate metabolic process', 'coenzyme A metabolic process', 'fatty acid biosynthetic process', 'lipid biosynthetic process', 'oxaloacetate metabolic process']
GTP-binding protein GEM
209
GTP-binding protein GEM
106
9.7
61
0.17
P55040P55040['cell surface receptor signaling pathway', 'chromosome organization', 'immune response', 'metaphase plate congression', 'mitotic cell cycle', 'negative regulation of high voltage-gated calcium channel activity', 'signal transduction']['cell surface receptor signaling pathway', 'chromosome organization', 'immune response', 'metaphase plate congression', 'mitotic cell cycle', 'negative regulation of high voltage-gated calcium channel activity', 'signal transduction']
Kinetochore-associated protein DSN1 homolog
191
Kinetochore-associated protein NSL1 homolog
40
2.0
65
0.76
Q9H410Q96IY1['cell division', 'mitotic sister chromatid segregation']['cell division', 'mitotic sister chromatid segregation']
Transforming growth factor beta-1 proprotein
33
Transforming growth factor beta activator LRRC32
350
2.0
62
0.79
P01137Q14392['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['negative regulation of activated T cell proliferation', 'negative regulation of cytokine production', 'positive regulation of gene expression', 'regulation of transforming growth factor beta activation', 'regulation of transforming growth factor beta3 activation', 'secondary palate development', 'transforming growth factor beta receptor signaling pathway']
F-box only protein 11
872
F-box only protein 11
899
3.9
53
0.49
Q86XK2Q86XK2['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']
Neurogenic locus notch homolog protein 3
1500
Neurogenic locus notch homolog protein 3
1500
9.7
57
0.18
Q9UM47Q9UM47['artery morphogenesis', 'axon guidance', 'forebrain development', 'glomerular capillary formation', 'negative regulation of neuron differentiation', 'negative regulation of transcription by RNA polymerase II', 'neuroblast differentiation', 'neuron fate commitment', 'Notch signaling pathway', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II']['artery morphogenesis', 'axon guidance', 'forebrain development', 'glomerular capillary formation', 'negative regulation of neuron differentiation', 'negative regulation of transcription by RNA polymerase II', 'neuroblast differentiation', 'neuron fate commitment', 'Notch signaling pathway', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II']
Amyloid-beta precursor protein
144
Amyloid-beta precursor protein
187
6.3
71
0.22
P05067P05067['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
B-cell antigen receptor complex-associated protein beta chain
135
B-cell antigen receptor complex-associated protein beta chain
135
2.0
64
0.76
P15530P15530['adaptive immune response', 'B cell differentiation', 'B cell receptor signaling pathway', 'response to bacterium']['adaptive immune response', 'B cell differentiation', 'B cell receptor signaling pathway', 'response to bacterium']
Annexin A2
9
Protein S100-A4
3
9.6
59
0.18
P07355P26447['angiogenesis', 'collagen fibril organization', 'fibrinolysis', 'membrane raft assembly', 'mRNA transcription by RNA polymerase II', 'negative regulation of low-density lipoprotein particle receptor catabolic process', 'negative regulation of receptor internalization', 'osteoclast development', 'positive regulation of exocytosis', 'positive regulation of low-density lipoprotein particle clearance', 'positive regulation of low-density lipoprotein particle receptor binding', 'positive regulation of low-density lipoprotein receptor activity', 'positive regulation of plasma membrane repair', 'positive regulation of plasminogen activation', 'positive regulation of receptor recycling', 'positive regulation of receptor-mediated endocytosis involved in cholesterol transport', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vacuole organization', 'positive regulation of vesicle fusion', 'regulation of neurogenesis', 'vesicle budding from membrane']['epithelial to mesenchymal transition', 'positive regulation of I-kappaB kinase/NF-kappaB signaling']
Interleukin-6 receptor subunit alpha
176
Interleukin-6 receptor subunit alpha
132
6.4
74
0.21
P08887P08887['acute-phase response', 'ciliary neurotrophic factor-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'endocrine pancreas development', 'extrinsic apoptotic signaling pathway', 'hepatic immune response', 'interleukin-6-mediated signaling pathway', 'monocyte chemotaxis', 'negative regulation of collagen biosynthetic process', 'negative regulation of interleukin-8 production', 'neutrophil mediated immunity', 'positive regulation of activation of Janus kinase activity', 'positive regulation of cell population proliferation', 'positive regulation of chemokine production', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of interleukin-6 production', 'positive regulation of leukocyte chemotaxis', 'positive regulation of MAPK cascade', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of platelet aggregation', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'response to cytokine', 'T-helper 17 cell lineage commitment', 'vascular endothelial growth factor production']['acute-phase response', 'ciliary neurotrophic factor-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'endocrine pancreas development', 'extrinsic apoptotic signaling pathway', 'hepatic immune response', 'interleukin-6-mediated signaling pathway', 'monocyte chemotaxis', 'negative regulation of collagen biosynthetic process', 'negative regulation of interleukin-8 production', 'neutrophil mediated immunity', 'positive regulation of activation of Janus kinase activity', 'positive regulation of cell population proliferation', 'positive regulation of chemokine production', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of interleukin-6 production', 'positive regulation of leukocyte chemotaxis', 'positive regulation of MAPK cascade', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of platelet aggregation', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'response to cytokine', 'T-helper 17 cell lineage commitment', 'vascular endothelial growth factor production']
F-box/LRR-repeat protein 2
33
S-phase kinase-associated protein 1
160
6.3
nan
nan
Q9UKC9P63208['modulation by host of viral RNA genome replication', 'protein modification process', 'protein monoubiquitination', 'protein ubiquitination', 'proteolysis', 'regulation of autophagy', 'regulation of phosphatidylinositol 3-kinase signaling', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process']['histone H2A monoubiquitination', 'maintenance of protein location in nucleus', 'positive regulation of ubiquitin protein ligase activity', 'protein K48-linked ubiquitination', 'protein polyubiquitination', 'protein ubiquitination', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process']
DNA topoisomerase 2-binding protein 1
1299
Histone lysine demethylase PHF8
844
2.0
54
0.91
Q92547Q9UPP1['cellular response to DNA damage stimulus', 'DNA metabolic process', 'DNA repair', 'DNA replication initiation', 'homologous recombination', 'mitotic DNA replication checkpoint signaling', 'mitotic G2 DNA damage checkpoint signaling', 'response to ionizing radiation']['brain development', 'chromatin organization', 'G1/S transition of mitotic cell cycle', 'histone H3-K27 demethylation', 'histone H3-K36 demethylation', 'histone H3-K9 demethylation', 'histone H4-K20 demethylation', 'negative regulation of ribosomal DNA heterochromatin assembly', 'positive regulation of transcription by RNA polymerase I', 'positive regulation of transcription, DNA-templated', 'protein demethylation', 'regulation of transcription by RNA polymerase II']
Neutrophil defensin 1
94
Neutrophil defensin 1
94
9.4
nan
nan
P59665P59665['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']
Amyloid beta precursor like protein 2
310
Amyloid beta precursor like protein 2
335
5.8
60
0.29
Q06481Q06481['axonogenesis', 'central nervous system development', 'G protein-coupled receptor signaling pathway', 'regulation of cellular protein metabolic process']['axonogenesis', 'central nervous system development', 'G protein-coupled receptor signaling pathway', 'regulation of cellular protein metabolic process']
Serine/threonine-protein kinase MARK2
210
Serine/threonine-protein kinase MARK2
210
2.0
60
0.81
O08679O08679['axon development', 'establishment of cell polarity', 'establishment or maintenance of cell polarity regulating cell shape', 'establishment or maintenance of epithelial cell apical/basal polarity', 'intracellular signal transduction', 'microtubule cytoskeleton organization', 'neuron migration', 'peptidyl-serine phosphorylation', 'positive regulation of neuron projection development', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of axonogenesis', 'regulation of cytoskeleton organization', 'regulation of microtubule binding', 'regulation of microtubule cytoskeleton organization', 'Wnt signaling pathway']['axon development', 'establishment of cell polarity', 'establishment or maintenance of cell polarity regulating cell shape', 'establishment or maintenance of epithelial cell apical/basal polarity', 'intracellular signal transduction', 'microtubule cytoskeleton organization', 'neuron migration', 'peptidyl-serine phosphorylation', 'positive regulation of neuron projection development', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of axonogenesis', 'regulation of cytoskeleton organization', 'regulation of microtubule binding', 'regulation of microtubule cytoskeleton organization', 'Wnt signaling pathway']
DNA repair protein XRCC4
130
DNA repair protein XRCC4
130
5.5
69
0.26
Q13426Q13426['DNA ligation involved in DNA repair', 'double-strand break repair', 'double-strand break repair via nonhomologous end joining', 'immunoglobulin V(D)J recombination', 'positive regulation of ligase activity', 'positive regulation of phosphatidylserine exposure on apoptotic cell surface', 'protein localization to site of double-strand break', 'response to X-ray']['DNA ligation involved in DNA repair', 'double-strand break repair', 'double-strand break repair via nonhomologous end joining', 'immunoglobulin V(D)J recombination', 'positive regulation of ligase activity', 'positive regulation of phosphatidylserine exposure on apoptotic cell surface', 'protein localization to site of double-strand break', 'response to X-ray']
Trypsin
181
Trypsin
181
6.4
82
0.19
P00761P00761['digestion', 'proteolysis']['digestion', 'proteolysis']
General transcription factor IIH subunit 3
142
General transcription factor IIH subunit 2
345
6.3
72
0.22
Q13889Q13888['DNA repair', 'nucleotide-excision repair', 'phosphorylation of RNA polymerase II C-terminal domain', 'transcription by RNA polymerase II']['G protein-coupled receptor internalization', 'nucleotide-excision repair', 'positive regulation of DNA helicase activity', 'regulation of transcription by RNA polymerase II', 'response to UV', 'transcription by RNA polymerase II', 'transcription initiation from RNA polymerase II promoter']
Fibrinogen gamma-B chain
32
Fibrinogen gamma-B chain
32
5.9
50
0.34
P12799P12799['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'platelet aggregation', 'protein polymerization']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'platelet aggregation', 'protein polymerization']
Caspase recruitment domain-containing protein 11
28
Caspase recruitment domain-containing protein 11
28
2.0
56
0.87
Q9BXL7Q9BXL7['B cell differentiation', 'B cell proliferation', 'CD4-positive, alpha-beta T cell proliferation', 'homeostasis of number of cells', 'I-kappaB kinase/NF-kappaB signaling', 'positive regulation of B cell proliferation', 'positive regulation of CD4-positive, alpha-beta T cell proliferation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interleukin-2 production', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of T cell receptor signaling pathway', 'protein homooligomerization', 'regulation of apoptotic process', 'regulation of B cell differentiation', 'regulation of T cell differentiation', 'T cell costimulation', 'thymic T cell selection', 'TORC1 signaling']['B cell differentiation', 'B cell proliferation', 'CD4-positive, alpha-beta T cell proliferation', 'homeostasis of number of cells', 'I-kappaB kinase/NF-kappaB signaling', 'positive regulation of B cell proliferation', 'positive regulation of CD4-positive, alpha-beta T cell proliferation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interleukin-2 production', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of T cell receptor signaling pathway', 'protein homooligomerization', 'regulation of apoptotic process', 'regulation of B cell differentiation', 'regulation of T cell differentiation', 'T cell costimulation', 'thymic T cell selection', 'TORC1 signaling']
Aphrodisin
58
Aphrodisin
58
2.9
47
0.74
P09465P09465[][]
Trypsin
33
Trypsin
181
9.6
79
0.13
P00761P00761['digestion', 'proteolysis']['digestion', 'proteolysis']
Mothers against decapentaplegic homolog 3
394
Mothers against decapentaplegic homolog 3
421
9.5
68
0.16
P84022P84022['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'activin receptor signaling pathway', 'adrenal gland development', 'anatomical structure morphogenesis', 'BMP signaling pathway', 'cell differentiation', 'cell-cell junction organization', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'developmental growth', 'embryonic cranial skeleton morphogenesis', 'embryonic foregut morphogenesis', 'embryonic pattern specification', 'endoderm development', 'extrinsic apoptotic signaling pathway', 'heart looping', 'immune response', 'immune system development', 'in utero embryonic development', 'JNK cascade', 'lens fiber cell differentiation', 'liver development', 'mesoderm formation', 'negative regulation of apoptotic process', 'negative regulation of cardiac muscle hypertrophy in response to stress', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cytosolic calcium ion concentration', 'negative regulation of fat cell differentiation', 'negative regulation of inflammatory response', 'negative regulation of lung blood pressure', 'negative regulation of osteoblast differentiation', 'negative regulation of osteoblast proliferation', 'negative regulation of protein catabolic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of wound healing', 'nodal signaling pathway', 'osteoblast development', 'paraxial mesoderm morphogenesis', 'pericardium development', 'positive regulation of alkaline phosphatase activity', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cell migration', 'positive regulation of chondrocyte differentiation', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of extracellular matrix assembly', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of interleukin-1 beta production', 'positive regulation of miRNA transcription', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of positive chemotaxis', 'positive regulation of protein import into nucleus', 'positive regulation of stress fiber assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta3 production', 'primary miRNA processing', 'protein stabilization', 'regulation of binding', 'regulation of epithelial cell proliferation', 'regulation of immune response', 'regulation of miRNA transcription', 'regulation of striated muscle tissue development', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'signal transduction involved in regulation of gene expression', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'somitogenesis', 'T cell activation', 'thyroid gland development', 'transdifferentiation', 'transforming growth factor beta receptor signaling pathway', 'ureteric bud development', 'wound healing']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'activin receptor signaling pathway', 'adrenal gland development', 'anatomical structure morphogenesis', 'BMP signaling pathway', 'cell differentiation', 'cell-cell junction organization', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'developmental growth', 'embryonic cranial skeleton morphogenesis', 'embryonic foregut morphogenesis', 'embryonic pattern specification', 'endoderm development', 'extrinsic apoptotic signaling pathway', 'heart looping', 'immune response', 'immune system development', 'in utero embryonic development', 'JNK cascade', 'lens fiber cell differentiation', 'liver development', 'mesoderm formation', 'negative regulation of apoptotic process', 'negative regulation of cardiac muscle hypertrophy in response to stress', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cytosolic calcium ion concentration', 'negative regulation of fat cell differentiation', 'negative regulation of inflammatory response', 'negative regulation of lung blood pressure', 'negative regulation of osteoblast differentiation', 'negative regulation of osteoblast proliferation', 'negative regulation of protein catabolic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of wound healing', 'nodal signaling pathway', 'osteoblast development', 'paraxial mesoderm morphogenesis', 'pericardium development', 'positive regulation of alkaline phosphatase activity', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cell migration', 'positive regulation of chondrocyte differentiation', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of extracellular matrix assembly', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of interleukin-1 beta production', 'positive regulation of miRNA transcription', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of positive chemotaxis', 'positive regulation of protein import into nucleus', 'positive regulation of stress fiber assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta3 production', 'primary miRNA processing', 'protein stabilization', 'regulation of binding', 'regulation of epithelial cell proliferation', 'regulation of immune response', 'regulation of miRNA transcription', 'regulation of striated muscle tissue development', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'signal transduction involved in regulation of gene expression', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'somitogenesis', 'T cell activation', 'thyroid gland development', 'transdifferentiation', 'transforming growth factor beta receptor signaling pathway', 'ureteric bud development', 'wound healing']
Coagulation factor XII
359
Coagulation factor XII
486
2.1
61
0.79
P00748P00748['blood coagulation', 'blood coagulation, intrinsic pathway', 'Factor XII activation', 'fibrinolysis', 'innate immune response', 'plasma kallikrein-kinin cascade', 'positive regulation of blood coagulation', 'positive regulation of fibrinolysis', 'positive regulation of plasminogen activation', 'protein autoprocessing', 'protein processing', 'proteolysis', 'response to misfolded protein', 'zymogen activation']['blood coagulation', 'blood coagulation, intrinsic pathway', 'Factor XII activation', 'fibrinolysis', 'innate immune response', 'plasma kallikrein-kinin cascade', 'positive regulation of blood coagulation', 'positive regulation of fibrinolysis', 'positive regulation of plasminogen activation', 'protein autoprocessing', 'protein processing', 'proteolysis', 'response to misfolded protein', 'zymogen activation']
PRSS3 protein
52
Pancreatic trypsin inhibitor
49
9.4
95
0.11
Q8N2U3P00974['proteolysis']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
G-rich sequence factor 1
476
G-rich sequence factor 1
476
2.0
53
0.92
Q12849Q12849['anterior/posterior pattern specification', 'morphogenesis of embryonic epithelium', 'mRNA polyadenylation', 'positive regulation of mitochondrial RNA catabolic process', 'regulation of RNA splicing', 'tRNA processing']['anterior/posterior pattern specification', 'morphogenesis of embryonic epithelium', 'mRNA polyadenylation', 'positive regulation of mitochondrial RNA catabolic process', 'regulation of RNA splicing', 'tRNA processing']
Urokinase-type plasminogen activator
168
Urokinase-type plasminogen activator
299
2.0
67
0.73
Q5SWW9Q5SWW9['blood coagulation', 'chemotaxis', 'fibrinolysis', 'negative regulation of fibrinolysis', 'negative regulation of plasminogen activation', 'plasminogen activation', 'positive regulation of cell migration', 'proteolysis', 'regulation of cell adhesion', 'regulation of cell adhesion mediated by integrin', 'regulation of cell population proliferation', 'regulation of fibrinolysis', 'regulation of plasminogen activation', 'regulation of signaling receptor activity', 'regulation of smooth muscle cell migration', 'regulation of smooth muscle cell-matrix adhesion', 'regulation of wound healing', 'response to hypoxia', 'signal transduction', 'smooth muscle cell migration', 'urokinase plasminogen activator signaling pathway']['blood coagulation', 'chemotaxis', 'fibrinolysis', 'negative regulation of fibrinolysis', 'negative regulation of plasminogen activation', 'plasminogen activation', 'positive regulation of cell migration', 'proteolysis', 'regulation of cell adhesion', 'regulation of cell adhesion mediated by integrin', 'regulation of cell population proliferation', 'regulation of fibrinolysis', 'regulation of plasminogen activation', 'regulation of signaling receptor activity', 'regulation of smooth muscle cell migration', 'regulation of smooth muscle cell-matrix adhesion', 'regulation of wound healing', 'response to hypoxia', 'signal transduction', 'smooth muscle cell migration', 'urokinase plasminogen activator signaling pathway']
Guanine nucleotide exchange factor VAV2
749
Thioredoxin-interacting protein
333
2.1
nan
nan
P52735Q9H3M7['angiogenesis', 'cell migration', 'cellular response to xenobiotic stimulus', 'Fc-epsilon receptor signaling pathway', 'Fc-gamma receptor signaling pathway involved in phagocytosis', 'lamellipodium assembly', 'platelet activation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'regulation of cell size', 'regulation of GTPase activity', 'regulation of small GTPase mediated signal transduction', 'signal transduction', 'small GTPase mediated signal transduction', 'vascular endothelial growth factor receptor signaling pathway']['cell cycle', 'cellular response to tumor cell', 'keratinocyte differentiation', 'negative regulation of cell division', 'negative regulation of transcription by RNA polymerase II', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of apoptotic process', 'protein import into nucleus', 'protein transport', 'regulation of cell population proliferation', 'response to calcium ion', 'response to estradiol', 'response to glucose', 'response to hydrogen peroxide', 'response to mechanical stimulus', 'response to progesterone', 'response to xenobiotic stimulus']
Bone marrow stromal antigen 2
58
Bone marrow stromal antigen 2
58
2.0
nan
nan
Q8R2Q8Q8R2Q8['defense response to virus', 'innate immune response', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of intracellular transport of viral material', 'negative regulation of plasmacytoid dendritic cell cytokine production', 'negative regulation of viral genome replication', 'regulation of actin cytoskeleton organization', 'response to interferon-alpha', 'response to interferon-beta', 'response to interferon-gamma', 'response to virus']['defense response to virus', 'innate immune response', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of intracellular transport of viral material', 'negative regulation of plasmacytoid dendritic cell cytokine production', 'negative regulation of viral genome replication', 'regulation of actin cytoskeleton organization', 'response to interferon-alpha', 'response to interferon-beta', 'response to interferon-gamma', 'response to virus']
Ribosomal oxygenase 1
300
60S ribosomal protein L8
220
2.0
74
0.66
Q9H6W3P62917['chromatin organization', 'histone H3-K36 demethylation', 'histone H3-K4 demethylation', 'negative regulation of osteoblast differentiation', 'negative regulation of transcription, DNA-templated']['cytoplasmic translation', 'translation']
Mitochondrial import receptor subunit TOM20 homolog
100
Aldehyde dehydrogenase, mitochondrial
26
2.0
nan
nan
Q62760P11884['protein import into mitochondrial matrix', 'protein targeting to mitochondrion', "response to 3,3',5-triiodo-L-thyronine", 'response to muscle activity', 'tRNA import into mitochondrion']['acetaldehyde metabolic process', 'aldehyde catabolic process', 'apoptotic mitochondrial changes', 'behavioral response to ethanol', 'cellular detoxification of aldehyde', 'cellular response to fatty acid', 'cellular response to hormone stimulus', 'cellular response to resveratrol', 'ethanol catabolic process', 'ethanol metabolic process', 'intrinsic apoptotic signaling pathway in response to oxidative stress', 'liver development', 'negative regulation of apoptotic process', 'regulation of dopamine biosynthetic process', 'regulation of inflammatory response', 'regulation of reactive oxygen species metabolic process', 'regulation of response to oxidative stress', 'regulation of serotonin biosynthetic process', 'response to estradiol', 'response to ethanol', 'response to heat', 'response to hyperoxia', 'response to ischemia', 'response to lipopolysaccharide', 'response to nicotine', 'response to organic cyclic compound', 'response to progesterone', 'response to testosterone']
Macrophage migration inhibitory factor
110
Macrophage migration inhibitory factor
81
2.0
81
0.61
P14174P14174['carboxylic acid metabolic process', 'cell surface receptor signaling pathway', 'cellular senescence', 'DNA damage response, signal transduction by p53 class mediator', 'inflammatory response', 'innate immune response', 'negative regulation of apoptotic process', 'negative regulation of cell migration', 'negative regulation of cellular senescence', 'negative regulation of DNA damage response, signal transduction by p53 class mediator', 'negative regulation of gene expression', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'negative regulation of macrophage chemotaxis', 'negative regulation of mature B cell apoptotic process', 'negative regulation of myeloid cell apoptotic process', 'negative regulation of protein metabolic process', 'positive regulation of arachidonic acid secretion', 'positive regulation of B cell proliferation', 'positive regulation of cell population proliferation', 'positive regulation of chemokine (C-X-C motif) ligand 2 production', 'positive regulation of cytokine production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of lipopolysaccharide-mediated signaling pathway', 'positive regulation of MAP kinase activity', 'positive regulation of myeloid leukocyte cytokine production involved in immune response', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of prostaglandin secretion involved in immune response', 'positive regulation of protein kinase A signaling', 'positive regulation of tumor necrosis factor production', 'prostaglandin biosynthetic process', 'protein homotrimerization', 'regulation of macrophage activation']['carboxylic acid metabolic process', 'cell surface receptor signaling pathway', 'cellular senescence', 'DNA damage response, signal transduction by p53 class mediator', 'inflammatory response', 'innate immune response', 'negative regulation of apoptotic process', 'negative regulation of cell migration', 'negative regulation of cellular senescence', 'negative regulation of DNA damage response, signal transduction by p53 class mediator', 'negative regulation of gene expression', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'negative regulation of macrophage chemotaxis', 'negative regulation of mature B cell apoptotic process', 'negative regulation of myeloid cell apoptotic process', 'negative regulation of protein metabolic process', 'positive regulation of arachidonic acid secretion', 'positive regulation of B cell proliferation', 'positive regulation of cell population proliferation', 'positive regulation of chemokine (C-X-C motif) ligand 2 production', 'positive regulation of cytokine production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of lipopolysaccharide-mediated signaling pathway', 'positive regulation of MAP kinase activity', 'positive regulation of myeloid leukocyte cytokine production involved in immune response', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of prostaglandin secretion involved in immune response', 'positive regulation of protein kinase A signaling', 'positive regulation of tumor necrosis factor production', 'prostaglandin biosynthetic process', 'protein homotrimerization', 'regulation of macrophage activation']
Superoxide dismutase [Cu-Zn]
201
Superoxide dismutase [Cu-Zn]
112
2.0
nan
nan
P00441P00441['aging', 'anterograde axonal transport', 'apoptotic process', 'auditory receptor cell stereocilium organization', 'cellular iron ion homeostasis', 'cellular response to ATP', 'cellular response to cadmium ion', 'cellular response to potassium ion', 'ectopic germ cell programmed cell death', 'embryo implantation', 'glutathione metabolic process', 'heart contraction', 'hydrogen peroxide biosynthetic process', 'locomotory behavior', 'muscle cell cellular homeostasis', 'myeloid cell homeostasis', 'negative regulation of cholesterol biosynthetic process', 'negative regulation of developmental process', 'negative regulation of inflammatory response', 'negative regulation of neuron apoptotic process', 'negative regulation of reproductive process', 'neurofilament cytoskeleton organization', 'ovarian follicle development', 'peripheral nervous system myelin maintenance', 'placenta development', 'positive regulation of apoptotic process', 'positive regulation of catalytic activity', 'positive regulation of cytokine production', 'positive regulation of MAPK cascade', 'positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'positive regulation of phagocytosis', 'positive regulation of superoxide anion generation', 'reactive oxygen species metabolic process', 'regulation of blood pressure', 'regulation of GTPase activity', 'regulation of mitochondrial membrane potential', 'regulation of multicellular organism growth', 'regulation of organ growth', 'regulation of protein kinase activity', 'regulation of T cell differentiation in thymus', 'relaxation of vascular associated smooth muscle', 'removal of superoxide radicals', 'response to amphetamine', 'response to antibiotic', 'response to antipsychotic drug', 'response to axon injury', 'response to carbon monoxide', 'response to copper ion', 'response to ethanol', 'response to heat', 'response to hydrogen peroxide', 'response to nutrient levels', 'response to organic substance', 'response to superoxide', 'response to xenobiotic stimulus', 'retina homeostasis', 'retrograde axonal transport', 'sensory perception of sound', 'spermatogenesis', 'superoxide anion generation', 'superoxide metabolic process', 'thymus development', 'transmission of nerve impulse']['aging', 'anterograde axonal transport', 'apoptotic process', 'auditory receptor cell stereocilium organization', 'cellular iron ion homeostasis', 'cellular response to ATP', 'cellular response to cadmium ion', 'cellular response to potassium ion', 'ectopic germ cell programmed cell death', 'embryo implantation', 'glutathione metabolic process', 'heart contraction', 'hydrogen peroxide biosynthetic process', 'locomotory behavior', 'muscle cell cellular homeostasis', 'myeloid cell homeostasis', 'negative regulation of cholesterol biosynthetic process', 'negative regulation of developmental process', 'negative regulation of inflammatory response', 'negative regulation of neuron apoptotic process', 'negative regulation of reproductive process', 'neurofilament cytoskeleton organization', 'ovarian follicle development', 'peripheral nervous system myelin maintenance', 'placenta development', 'positive regulation of apoptotic process', 'positive regulation of catalytic activity', 'positive regulation of cytokine production', 'positive regulation of MAPK cascade', 'positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'positive regulation of phagocytosis', 'positive regulation of superoxide anion generation', 'reactive oxygen species metabolic process', 'regulation of blood pressure', 'regulation of GTPase activity', 'regulation of mitochondrial membrane potential', 'regulation of multicellular organism growth', 'regulation of organ growth', 'regulation of protein kinase activity', 'regulation of T cell differentiation in thymus', 'relaxation of vascular associated smooth muscle', 'removal of superoxide radicals', 'response to amphetamine', 'response to antibiotic', 'response to antipsychotic drug', 'response to axon injury', 'response to carbon monoxide', 'response to copper ion', 'response to ethanol', 'response to heat', 'response to hydrogen peroxide', 'response to nutrient levels', 'response to organic substance', 'response to superoxide', 'response to xenobiotic stimulus', 'retina homeostasis', 'retrograde axonal transport', 'sensory perception of sound', 'spermatogenesis', 'superoxide anion generation', 'superoxide metabolic process', 'thymus development', 'transmission of nerve impulse']
Isoform A of Ketohexokinase
32
Isoform A of Ketohexokinase
98
9.4
75
0.14
P50053-2P50053-2[][]
Macrophage migration inhibitory factor
60
Macrophage migration inhibitory factor
110
7.1
68
0.21
P14174P14174['carboxylic acid metabolic process', 'cell surface receptor signaling pathway', 'cellular senescence', 'DNA damage response, signal transduction by p53 class mediator', 'inflammatory response', 'innate immune response', 'negative regulation of apoptotic process', 'negative regulation of cell migration', 'negative regulation of cellular senescence', 'negative regulation of DNA damage response, signal transduction by p53 class mediator', 'negative regulation of gene expression', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'negative regulation of macrophage chemotaxis', 'negative regulation of mature B cell apoptotic process', 'negative regulation of myeloid cell apoptotic process', 'negative regulation of protein metabolic process', 'positive regulation of arachidonic acid secretion', 'positive regulation of B cell proliferation', 'positive regulation of cell population proliferation', 'positive regulation of chemokine (C-X-C motif) ligand 2 production', 'positive regulation of cytokine production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of lipopolysaccharide-mediated signaling pathway', 'positive regulation of MAP kinase activity', 'positive regulation of myeloid leukocyte cytokine production involved in immune response', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of prostaglandin secretion involved in immune response', 'positive regulation of protein kinase A signaling', 'positive regulation of tumor necrosis factor production', 'prostaglandin biosynthetic process', 'protein homotrimerization', 'regulation of macrophage activation']['carboxylic acid metabolic process', 'cell surface receptor signaling pathway', 'cellular senescence', 'DNA damage response, signal transduction by p53 class mediator', 'inflammatory response', 'innate immune response', 'negative regulation of apoptotic process', 'negative regulation of cell migration', 'negative regulation of cellular senescence', 'negative regulation of DNA damage response, signal transduction by p53 class mediator', 'negative regulation of gene expression', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'negative regulation of macrophage chemotaxis', 'negative regulation of mature B cell apoptotic process', 'negative regulation of myeloid cell apoptotic process', 'negative regulation of protein metabolic process', 'positive regulation of arachidonic acid secretion', 'positive regulation of B cell proliferation', 'positive regulation of cell population proliferation', 'positive regulation of chemokine (C-X-C motif) ligand 2 production', 'positive regulation of cytokine production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of lipopolysaccharide-mediated signaling pathway', 'positive regulation of MAP kinase activity', 'positive regulation of myeloid leukocyte cytokine production involved in immune response', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of prostaglandin secretion involved in immune response', 'positive regulation of protein kinase A signaling', 'positive regulation of tumor necrosis factor production', 'prostaglandin biosynthetic process', 'protein homotrimerization', 'regulation of macrophage activation']
Human nkt tcr alpha chain
164
T cell receptor beta constant 2
168
2.0
73
0.67
K7N5M3A0A5B9[]['adaptive immune response', 'alpha-beta T cell activation', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'T cell receptor signaling pathway']
Cytochrome c oxidase assembly factor 6 homolog
59
Cytochrome c oxidase assembly factor 6 homolog
90
8.3
61
0.2
Q5JTJ3Q5JTJ3['mitochondrial ATP synthesis coupled electron transport', 'plasma membrane ATP synthesis coupled electron transport', 'respiratory chain complex IV assembly']['mitochondrial ATP synthesis coupled electron transport', 'plasma membrane ATP synthesis coupled electron transport', 'respiratory chain complex IV assembly']
Immunoglobulin heavy constant gamma 1
356
Immunoglobulin heavy constant gamma 1
250
9.4
70
0.15
P01857P01857['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
Immunoglobulin lambda constant 1
105
Immunoglobulin heavy variable 3-33
221
2.0
33
1.49
P01842P01772['adaptive immune response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
Egl nine homolog 1
323
Hypoxia-inducible factor 1-alpha
412
9.9
75
0.13
Q9GZT9Q16665['cardiac muscle tissue morphogenesis', 'cellular iron ion homeostasis', 'cellular response to hypoxia', 'heart trabecula formation', 'labyrinthine layer development', 'negative regulation of cyclic-nucleotide phosphodiesterase activity', 'negative regulation of DNA-binding transcription factor activity', 'oxygen homeostasis', 'peptidyl-proline hydroxylation to 4-hydroxy-L-proline', 'positive regulation of transcription by RNA polymerase II', 'regulation of angiogenesis', 'regulation of neuron death', 'regulation of postsynapse organization', 'regulation of protein catabolic process at postsynapse, modulating synaptic transmission', 'response to hypoxia', 'response to nitric oxide', 'ventricular septum morphogenesis']['angiogenesis', 'axonal transport of mitochondrion', 'B-1 B cell homeostasis', 'bone mineralization', 'cardiac ventricle morphogenesis', 'cellular glucose homeostasis', 'cellular iron ion homeostasis', 'cellular response to hypoxia', 'cellular response to interleukin-1', 'cellular response to virus', 'cerebral cortex development', 'chondrocyte differentiation', 'collagen metabolic process', 'connective tissue replacement involved in inflammatory response wound healing', 'digestive tract morphogenesis', 'dopaminergic neuron differentiation', 'elastin metabolic process', 'embryonic hemopoiesis', 'embryonic placenta development', 'epithelial cell differentiation involved in mammary gland alveolus development', 'epithelial to mesenchymal transition', 'glandular epithelial cell maturation', 'heart looping', 'hemoglobin biosynthetic process', 'hypoxia-inducible factor-1alpha signaling pathway', 'insulin secretion involved in cellular response to glucose stimulus', 'intestinal epithelial cell maturation', 'iris morphogenesis', 'lactate metabolic process', 'lactation', 'mesenchymal cell apoptotic process', 'muscle cell cellular homeostasis', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'negative regulation of growth', 'negative regulation of mesenchymal cell apoptotic process', 'negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of thymocyte apoptotic process', 'negative regulation of TOR signaling', 'neural crest cell migration', 'neural fold elevation formation', 'neuroblast proliferation', 'neuron apoptotic process', 'outflow tract morphogenesis', 'oxygen homeostasis', 'positive regulation of angiogenesis', 'positive regulation of autophagy of mitochondrion', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of chemokine production', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of erythrocyte differentiation', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of hormone biosynthetic process', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of macroautophagy', 'positive regulation of miRNA transcription', 'positive regulation of neuroblast proliferation', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of signaling receptor activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of aerobic respiration', 'regulation of gene expression', 'regulation of glycolytic process', 'regulation of protein neddylation', 'regulation of transcription by RNA polymerase II', 'regulation of transcription from RNA polymerase II promoter in response to oxidative stress', 'regulation of transcription, DNA-templated', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to iron ion', 'response to muscle activity', 'response to reactive oxygen species', 'retina vasculature development in camera-type eye', 'signal transduction', 'TOR signaling', 'vascular endothelial growth factor production', 'visual learning']
Immunoglobulin heavy constant gamma 1
112
Immunoglobulin heavy constant gamma 1
250
8.7
71
0.16
P01857P01857['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
If kappa light chain
219
Anti-human Fc gamma receptor III 3G8 gamma heavy chain variable region
128
7.3
nan
nan
A2NHM3Q811U5[][]
BTB/POZ domain-containing protein KCTD12
300
BTB/POZ domain-containing protein KCTD12
300
5.6
nan
nan
Q96CX2Q96CX2['protein homooligomerization']['protein homooligomerization']
AP-2 complex subunit mu
337
AP-2 complex subunit mu
501
6.9
75
0.19
P84092P84092['clathrin-dependent endocytosis', 'endocytosis', 'intracellular protein transport', 'negative regulation of protein localization to plasma membrane', 'positive regulation of receptor internalization', 'positive regulation of synaptic vesicle endocytosis', 'postsynaptic neurotransmitter receptor internalization', 'protein-containing complex assembly', 'receptor internalization', 'regulation of vesicle size', 'synaptic vesicle endocytosis', 'vesicle budding from membrane', 'vesicle-mediated transport']['clathrin-dependent endocytosis', 'endocytosis', 'intracellular protein transport', 'negative regulation of protein localization to plasma membrane', 'positive regulation of receptor internalization', 'positive regulation of synaptic vesicle endocytosis', 'postsynaptic neurotransmitter receptor internalization', 'protein-containing complex assembly', 'receptor internalization', 'regulation of vesicle size', 'synaptic vesicle endocytosis', 'vesicle budding from membrane', 'vesicle-mediated transport']
Mitochondrial import receptor subunit TOM20 homolog
100
Aldehyde dehydrogenase, mitochondrial
16
4.3
67
0.35
Q62760P11884['protein import into mitochondrial matrix', 'protein targeting to mitochondrion', "response to 3,3',5-triiodo-L-thyronine", 'response to muscle activity', 'tRNA import into mitochondrion']['acetaldehyde metabolic process', 'aldehyde catabolic process', 'apoptotic mitochondrial changes', 'behavioral response to ethanol', 'cellular detoxification of aldehyde', 'cellular response to fatty acid', 'cellular response to hormone stimulus', 'cellular response to resveratrol', 'ethanol catabolic process', 'ethanol metabolic process', 'intrinsic apoptotic signaling pathway in response to oxidative stress', 'liver development', 'negative regulation of apoptotic process', 'regulation of dopamine biosynthetic process', 'regulation of inflammatory response', 'regulation of reactive oxygen species metabolic process', 'regulation of response to oxidative stress', 'regulation of serotonin biosynthetic process', 'response to estradiol', 'response to ethanol', 'response to heat', 'response to hyperoxia', 'response to ischemia', 'response to lipopolysaccharide', 'response to nicotine', 'response to organic cyclic compound', 'response to progesterone', 'response to testosterone']
Cardiac phospholamban
36
Cardiac phospholamban
30
4.0
55
0.46
P61012P61012['adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'cardiac muscle tissue development', 'cellular calcium ion homeostasis', 'muscle cell cellular homeostasis', 'negative regulation of ATP-dependent activity', 'negative regulation of ATPase-coupled calcium transmembrane transporter activity', 'negative regulation of calcium ion binding', 'negative regulation of calcium ion import into sarcoplasmic reticulum', 'negative regulation of calcium ion transmembrane transporter activity', 'negative regulation of heart rate', 'Notch signaling pathway', 'regulation of calcium ion import', 'regulation of calcium ion transport', 'regulation of cardiac muscle cell contraction', 'regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion', 'regulation of relaxation of muscle', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of the force of heart contraction by cardiac conduction']['adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'cardiac muscle tissue development', 'cellular calcium ion homeostasis', 'muscle cell cellular homeostasis', 'negative regulation of ATP-dependent activity', 'negative regulation of ATPase-coupled calcium transmembrane transporter activity', 'negative regulation of calcium ion binding', 'negative regulation of calcium ion import into sarcoplasmic reticulum', 'negative regulation of calcium ion transmembrane transporter activity', 'negative regulation of heart rate', 'Notch signaling pathway', 'regulation of calcium ion import', 'regulation of calcium ion transport', 'regulation of cardiac muscle cell contraction', 'regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion', 'regulation of relaxation of muscle', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of the force of heart contraction by cardiac conduction']
T-cell receptor, sp3.4 alpha chain
161
T cell receptor beta constant 1
168
2.1
84
0.58
K7N5M9P01850[]['adaptive immune response', 'alpha-beta T cell activation', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'T cell receptor signaling pathway']
Lysozyme C
64
Lysozyme C
99
9.2
88
0.12
P61626P61626['antimicrobial humoral response', 'cytolysis', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'inflammatory response', 'killing of cells of another organism', 'metabolic process', 'retina homeostasis']['antimicrobial humoral response', 'cytolysis', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'inflammatory response', 'killing of cells of another organism', 'metabolic process', 'retina homeostasis']
Lymphocyte antigen 6 complex locus protein G6d
102
Lymphocyte antigen 6 complex locus protein G6d
102
5.9
63
0.27
O95868O95868['acetylcholine receptor signaling pathway']['acetylcholine receptor signaling pathway']
Cartilage oligomeric matrix protein
71
Cartilage oligomeric matrix protein
71
5.9
51
0.33
P35444P35444['apoptotic process', 'artery morphogenesis', 'blood coagulation', 'BMP signaling pathway', 'bone growth', 'bone mineralization', 'bone morphogenesis', 'cartilage development', 'cartilage homeostasis', 'chondrocyte development', 'chondrocyte proliferation', 'collagen fibril organization', 'endochondral bone growth', 'growth plate cartilage development', 'limb development', 'multicellular organism aging', 'multicellular organism growth', 'muscle cell development', 'musculoskeletal movement', 'negative regulation of apoptotic process', 'negative regulation of hemostasis', 'neuromuscular process', 'ossification', 'platelet aggregation', 'positive regulation of chondrocyte proliferation', 'protein homooligomerization', 'protein processing', 'protein secretion', 'regulation of bone mineralization', 'regulation of gene expression', 'response to unfolded protein', 'skeletal system development', 'skin development', 'tendon development', 'vascular associated smooth muscle cell development', 'vascular associated smooth muscle contraction']['apoptotic process', 'artery morphogenesis', 'blood coagulation', 'BMP signaling pathway', 'bone growth', 'bone mineralization', 'bone morphogenesis', 'cartilage development', 'cartilage homeostasis', 'chondrocyte development', 'chondrocyte proliferation', 'collagen fibril organization', 'endochondral bone growth', 'growth plate cartilage development', 'limb development', 'multicellular organism aging', 'multicellular organism growth', 'muscle cell development', 'musculoskeletal movement', 'negative regulation of apoptotic process', 'negative regulation of hemostasis', 'neuromuscular process', 'ossification', 'platelet aggregation', 'positive regulation of chondrocyte proliferation', 'protein homooligomerization', 'protein processing', 'protein secretion', 'regulation of bone mineralization', 'regulation of gene expression', 'response to unfolded protein', 'skeletal system development', 'skin development', 'tendon development', 'vascular associated smooth muscle cell development', 'vascular associated smooth muscle contraction']
Defensin alpha 5
65
Defensin alpha 5
65
6.6
69
0.22
Q01523Q01523['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']
Hepcidin
82
Neutrophil gelatinase-associated lipocalin
76
8.7
69
0.17
P81172P80188['acute-phase response', 'aging', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular iron ion homeostasis', 'cellular response to bile acid', 'cellular response to interleukin-6', 'cellular response to lipopolysaccharide', 'cellular response to tumor necrosis factor', 'cellular response to X-ray', 'defense response to bacterium', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'establishment of localization in cell', 'immune response', 'iron ion transmembrane transport', 'killing of cells of another organism', 'liver regeneration', 'macrophage activation', 'multicellular organismal iron ion homeostasis', 'myeloid cell homeostasis', 'negative regulation of bone resorption', 'negative regulation of inflammatory response', 'negative regulation of intestinal absorption', 'negative regulation of ion transmembrane transporter activity', 'negative regulation of iron export across plasma membrane', 'negative regulation of iron ion transmembrane transport', 'negative regulation of iron ion transmembrane transporter activity', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of macrophage activation', 'positive regulation of protein catabolic process', 'positive regulation of protein polyubiquitination', 'positive regulation of receptor catabolic process', 'positive regulation of receptor internalization', 'positive regulation of transcription by RNA polymerase II', 'protein catabolic process', 'receptor signaling pathway via JAK-STAT', 'response to erythropoietin', 'response to ethanol', 'response to iron ion', 'response to iron ion starvation', 'response to vitamin A', 'response to zinc ion', 'transcription by RNA polymerase II']['apoptotic process', 'defense response to bacterium', 'innate immune response', 'positive regulation of cold-induced thermogenesis', 'sequestering of iron ion', 'siderophore transport']
Coagulation factor VII
77
Tissue factor
241
9.1
nan
nan
P08709P13726['activation of blood coagulation via clotting cascade', 'animal organ regeneration', 'blood coagulation', 'blood coagulation, extrinsic pathway', 'blood coagulation, fibrin clot formation', 'blood coagulation, intrinsic pathway', 'circadian rhythm', 'positive regulation of blood coagulation', 'positive regulation of cell migration', 'positive regulation of leukocyte chemotaxis', 'positive regulation of platelet-derived growth factor receptor signaling pathway', 'positive regulation of positive chemotaxis', 'positive regulation of protein kinase B signaling', 'protein processing', 'proteolysis', 'response to 2,3,7,8-tetrachlorodibenzodioxine', 'response to anticoagulant', 'response to astaxanthin', 'response to carbon dioxide', 'response to cholesterol', 'response to estradiol', 'response to estrogen', 'response to genistein', 'response to growth hormone', 'response to hypoxia', 'response to Thyroid stimulating hormone', 'response to thyrotropin-releasing hormone', 'response to thyroxine', 'response to vitamin K', 'response to wounding', 'zymogen activation']['activation of blood coagulation via clotting cascade', 'activation of cysteine-type endopeptidase activity involved in apoptotic process', 'activation of plasma proteins involved in acute inflammatory response', 'blood coagulation', 'blood coagulation, extrinsic pathway', 'blood coagulation, fibrin clot formation', 'blood coagulation, intrinsic pathway', 'cytokine-mediated signaling pathway', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of gene expression', 'positive regulation of interleukin-8 production', 'positive regulation of platelet-derived growth factor receptor signaling pathway', 'positive regulation of positive chemotaxis', 'positive regulation of protein kinase B signaling', 'protein processing', 'proteolysis', 'response to wounding']
Store-operated calcium entry-associated regulatory factor
320
Store-operated calcium entry-associated regulatory factor
97
8.7
61
0.19
Q96BY9Q96BY9['calcium ion transport', 'regulation of store-operated calcium entry']['calcium ion transport', 'regulation of store-operated calcium entry']
TRA@ protein
161
Human nkt tcr beta chain
176
2.0
77
0.64
Q6IRV4K7N5M4[][]
Neutrophil defensin 1
66
Neutrophil defensin 1
66
4.7
79
0.27
P59665P59665['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
545
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
545
9.8
74
0.14
Q6RHR9Q6RHR9['positive regulation of cell-cell adhesion', 'signal transduction']['positive regulation of cell-cell adhesion', 'signal transduction']
Repulsive guidance molecule B
139
Repulsive guidance molecule B
226
2.0
44
1.11
Q6NW40Q6NW40['BMP signaling pathway', 'cell adhesion', 'positive regulation of transcription, DNA-templated', 'signal transduction']['BMP signaling pathway', 'cell adhesion', 'positive regulation of transcription, DNA-templated', 'signal transduction']
DNA repair protein RAD52 homolog
25
DNA repair protein RAD52 homolog
25
9.5
nan
nan
P43351P43351['cellular response to DNA damage stimulus', 'cellular response to oxidative stress', 'DNA double-strand break processing involved in repair via single-strand annealing', 'DNA recombinase assembly', 'DNA recombination', 'double-strand break repair', 'double-strand break repair via homologous recombination', 'double-strand break repair via single-strand annealing', 'mitotic recombination', 'regulation of nucleotide-excision repair']['cellular response to DNA damage stimulus', 'cellular response to oxidative stress', 'DNA double-strand break processing involved in repair via single-strand annealing', 'DNA recombinase assembly', 'DNA recombination', 'double-strand break repair', 'double-strand break repair via homologous recombination', 'double-strand break repair via single-strand annealing', 'mitotic recombination', 'regulation of nucleotide-excision repair']
ATPase WRNIP1
39
ATPase WRNIP1
39
2.0
37
1.33
Q96S55Q96S55['DNA synthesis involved in DNA repair', 'DNA-templated DNA replication', 'innate immune response', 'regulation of DNA repair', 'regulation of DNA-templated DNA replication initiation']['DNA synthesis involved in DNA repair', 'DNA-templated DNA replication', 'innate immune response', 'regulation of DNA repair', 'regulation of DNA-templated DNA replication initiation']
Dynamin-binding protein
300
Dynamin-binding protein
300
5.3
55
0.34
Q6XZF7Q6XZF7['aging', 'intracellular signal transduction', 'regulation of cell shape', 'regulation of small GTPase mediated signal transduction']['aging', 'intracellular signal transduction', 'regulation of cell shape', 'regulation of small GTPase mediated signal transduction']
Nesprin-4
381
Nesprin-4
382
3.9
nan
nan
Q8N205Q8N205['establishment of epithelial cell apical/basal polarity']['establishment of epithelial cell apical/basal polarity']
Trypsin-3
253
Tissue factor pathway inhibitor
171
8.8
100
0.11
P35030P10646['antimicrobial humoral response', 'digestion', 'endothelial cell migration', 'proteolysis', 'zymogen activation']['blood coagulation', 'cellular response to steroid hormone stimulus', 'negative regulation of blood coagulation']
Lymphocyte antigen 6 complex locus protein G6d
102
Lymphocyte antigen 6 complex locus protein G6d
96
5.3
67
0.28
O95868O95868['acetylcholine receptor signaling pathway']['acetylcholine receptor signaling pathway']
Glycoprotein hormones alpha chain
31
Follitropin subunit beta
21
9.5
nan
nan
P01215P01225['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
NACHT, LRR and PYD domains-containing protein 12
11
NACHT, LRR and PYD domains-containing protein 12
11
2.0
75
0.65
P59046P59046['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'cellular response to cytokine stimulus', 'dendritic cell migration', 'ERK1 and ERK2 cascade', 'negative regulation of cytokine production', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of inflammatory response', 'negative regulation of interleukin-1 production', 'negative regulation of interleukin-6 production', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of NIK/NF-kappaB signaling', 'negative regulation of protein autophosphorylation', 'negative regulation of signal transduction', 'negative regulation of Toll signaling pathway', 'NIK/NF-kappaB signaling', 'positive regulation of inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of MHC class I biosynthetic process', 'positive regulation of NIK/NF-kappaB signaling', 'regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of inflammatory response', 'regulation of interleukin-18 production', 'signal transduction']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'cellular response to cytokine stimulus', 'dendritic cell migration', 'ERK1 and ERK2 cascade', 'negative regulation of cytokine production', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of inflammatory response', 'negative regulation of interleukin-1 production', 'negative regulation of interleukin-6 production', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of NIK/NF-kappaB signaling', 'negative regulation of protein autophosphorylation', 'negative regulation of signal transduction', 'negative regulation of Toll signaling pathway', 'NIK/NF-kappaB signaling', 'positive regulation of inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of MHC class I biosynthetic process', 'positive regulation of NIK/NF-kappaB signaling', 'regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of inflammatory response', 'regulation of interleukin-18 production', 'signal transduction']
Thioredoxin reductase 1, cytoplasmic
533
Thioredoxin
32
2.0
76
0.64
Q16881P10599['cell population proliferation', 'cell redox homeostasis', 'mesoderm formation', 'signal transduction']['activation of protein kinase B activity', 'cell redox homeostasis', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of protein export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA binding', 'positive regulation of peptidyl-cysteine S-nitrosylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'response to nitric oxide', 'response to radiation']
Endothelin-1
67
Endothelin-1
67
4.6
56
0.39
P05305P05305['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'artery smooth muscle contraction', 'axon extension', 'axonogenesis involved in innervation', 'body fluid secretion', 'branching involved in blood vessel morphogenesis', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cardiac neural crest cell migration involved in outflow tract morphogenesis', 'cartilage development', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to calcium ion', 'cellular response to fatty acid', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to human chorionic gonadotropin stimulus', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to luteinizing hormone stimulus', 'cellular response to mineralocorticoid stimulus', 'cellular response to organic substance', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to xenobiotic stimulus', 'dorsal/ventral pattern formation', 'embryonic heart tube development', 'endothelin receptor signaling pathway', 'endothelin receptor signaling pathway involved in heart process', 'epithelial fluid transport', 'ERK1 and ERK2 cascade', 'G protein-coupled receptor signaling pathway', 'histamine secretion', 'I-kappaB kinase/NF-kappaB signaling', 'in utero embryonic development', 'inositol phosphate-mediated signaling', 'leukocyte activation', 'maternal process involved in parturition', 'meiotic cell cycle process involved in oocyte maturation', 'membrane depolarization', 'middle ear morphogenesis', 'mitochondrion organization', 'multicellular organism aging', 'negative regulation of blood coagulation', 'negative regulation of gene expression', 'negative regulation of hormone secretion', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein metabolic process', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'neural crest cell fate commitment', 'nitric oxide transport', 'noradrenergic neuron differentiation', 'peptide hormone secretion', 'pharyngeal arch artery morphogenesis', 'phosphatidylinositol 3-kinase signaling', 'phospholipase D-activating G protein-coupled receptor signaling pathway', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cation channel activity', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell size', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell migration', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of JUN kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of odontogenesis', 'positive regulation of prostaglandin secretion', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'positive regulation of renal sodium excretion', 'positive regulation of sarcomere organization', 'positive regulation of signaling receptor activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'prostaglandin biosynthetic process', 'protein kinase A signaling', 'protein kinase C deactivation', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'regulation of glucose transmembrane transport', 'regulation of pH', 'regulation of sensory perception of pain', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'renal sodium ion absorption', 'respiratory gaseous exchange by respiratory system', 'response to activity', 'response to amino acid', 'response to amphetamine', 'response to dexamethasone', 'response to leptin', 'response to lipopolysaccharide', 'response to muscle stretch', 'response to nicotine', 'response to ozone', 'response to prostaglandin F', 'response to salt', 'response to testosterone', 'rhythmic excitation', 'semaphorin-plexin signaling pathway involved in axon guidance', 'sensory perception of pain', 'superoxide anion generation', 'sympathetic neuron axon guidance', 'thyroid gland development', 'transcription by RNA polymerase II', 'vasoconstriction', 'vein smooth muscle contraction']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'artery smooth muscle contraction', 'axon extension', 'axonogenesis involved in innervation', 'body fluid secretion', 'branching involved in blood vessel morphogenesis', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cardiac neural crest cell migration involved in outflow tract morphogenesis', 'cartilage development', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to calcium ion', 'cellular response to fatty acid', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to human chorionic gonadotropin stimulus', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to luteinizing hormone stimulus', 'cellular response to mineralocorticoid stimulus', 'cellular response to organic substance', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to xenobiotic stimulus', 'dorsal/ventral pattern formation', 'embryonic heart tube development', 'endothelin receptor signaling pathway', 'endothelin receptor signaling pathway involved in heart process', 'epithelial fluid transport', 'ERK1 and ERK2 cascade', 'G protein-coupled receptor signaling pathway', 'histamine secretion', 'I-kappaB kinase/NF-kappaB signaling', 'in utero embryonic development', 'inositol phosphate-mediated signaling', 'leukocyte activation', 'maternal process involved in parturition', 'meiotic cell cycle process involved in oocyte maturation', 'membrane depolarization', 'middle ear morphogenesis', 'mitochondrion organization', 'multicellular organism aging', 'negative regulation of blood coagulation', 'negative regulation of gene expression', 'negative regulation of hormone secretion', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein metabolic process', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'neural crest cell fate commitment', 'nitric oxide transport', 'noradrenergic neuron differentiation', 'peptide hormone secretion', 'pharyngeal arch artery morphogenesis', 'phosphatidylinositol 3-kinase signaling', 'phospholipase D-activating G protein-coupled receptor signaling pathway', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cation channel activity', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell size', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell migration', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of JUN kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of odontogenesis', 'positive regulation of prostaglandin secretion', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'positive regulation of renal sodium excretion', 'positive regulation of sarcomere organization', 'positive regulation of signaling receptor activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'prostaglandin biosynthetic process', 'protein kinase A signaling', 'protein kinase C deactivation', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'regulation of glucose transmembrane transport', 'regulation of pH', 'regulation of sensory perception of pain', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'renal sodium ion absorption', 'respiratory gaseous exchange by respiratory system', 'response to activity', 'response to amino acid', 'response to amphetamine', 'response to dexamethasone', 'response to leptin', 'response to lipopolysaccharide', 'response to muscle stretch', 'response to nicotine', 'response to ozone', 'response to prostaglandin F', 'response to salt', 'response to testosterone', 'rhythmic excitation', 'semaphorin-plexin signaling pathway involved in axon guidance', 'sensory perception of pain', 'superoxide anion generation', 'sympathetic neuron axon guidance', 'thyroid gland development', 'transcription by RNA polymerase II', 'vasoconstriction', 'vein smooth muscle contraction']
Protein NDRG3
30
Protein NDRG3
30
2.0
56
0.88
Q9UGV2Q9UGV2['cell differentiation', 'negative regulation of cell growth', 'signal transduction', 'spermatogenesis']['cell differentiation', 'negative regulation of cell growth', 'signal transduction', 'spermatogenesis']
Hepcidin
72
Neutrophil gelatinase-associated lipocalin
76
9.8
79
0.13
P81172P80188['acute-phase response', 'aging', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular iron ion homeostasis', 'cellular response to bile acid', 'cellular response to interleukin-6', 'cellular response to lipopolysaccharide', 'cellular response to tumor necrosis factor', 'cellular response to X-ray', 'defense response to bacterium', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'establishment of localization in cell', 'immune response', 'iron ion transmembrane transport', 'killing of cells of another organism', 'liver regeneration', 'macrophage activation', 'multicellular organismal iron ion homeostasis', 'myeloid cell homeostasis', 'negative regulation of bone resorption', 'negative regulation of inflammatory response', 'negative regulation of intestinal absorption', 'negative regulation of ion transmembrane transporter activity', 'negative regulation of iron export across plasma membrane', 'negative regulation of iron ion transmembrane transport', 'negative regulation of iron ion transmembrane transporter activity', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of macrophage activation', 'positive regulation of protein catabolic process', 'positive regulation of protein polyubiquitination', 'positive regulation of receptor catabolic process', 'positive regulation of receptor internalization', 'positive regulation of transcription by RNA polymerase II', 'protein catabolic process', 'receptor signaling pathway via JAK-STAT', 'response to erythropoietin', 'response to ethanol', 'response to iron ion', 'response to iron ion starvation', 'response to vitamin A', 'response to zinc ion', 'transcription by RNA polymerase II']['apoptotic process', 'defense response to bacterium', 'innate immune response', 'positive regulation of cold-induced thermogenesis', 'sequestering of iron ion', 'siderophore transport']
Myotrophin
2
Myotrophin
2
2.0
58
0.84
P58546P58546['catecholamine metabolic process', 'cellular response to mechanical stimulus', 'cerebellar granule cell differentiation', 'neuron differentiation', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cell growth', 'positive regulation of macromolecule biosynthetic process', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein metabolic process', 'regulation of barbed-end actin filament capping', 'regulation of cell size', 'regulation of striated muscle tissue development', 'regulation of translation', 'skeletal muscle tissue regeneration', 'striated muscle cell differentiation']['catecholamine metabolic process', 'cellular response to mechanical stimulus', 'cerebellar granule cell differentiation', 'neuron differentiation', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cell growth', 'positive regulation of macromolecule biosynthetic process', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein metabolic process', 'regulation of barbed-end actin filament capping', 'regulation of cell size', 'regulation of striated muscle tissue development', 'regulation of translation', 'skeletal muscle tissue regeneration', 'striated muscle cell differentiation']
Egl nine homolog 1
283
Hypoxia-inducible factor 1-alpha
412
9.2
67
0.16
Q9GZT9Q16665['cardiac muscle tissue morphogenesis', 'cellular iron ion homeostasis', 'cellular response to hypoxia', 'heart trabecula formation', 'labyrinthine layer development', 'negative regulation of cyclic-nucleotide phosphodiesterase activity', 'negative regulation of DNA-binding transcription factor activity', 'oxygen homeostasis', 'peptidyl-proline hydroxylation to 4-hydroxy-L-proline', 'positive regulation of transcription by RNA polymerase II', 'regulation of angiogenesis', 'regulation of neuron death', 'regulation of postsynapse organization', 'regulation of protein catabolic process at postsynapse, modulating synaptic transmission', 'response to hypoxia', 'response to nitric oxide', 'ventricular septum morphogenesis']['angiogenesis', 'axonal transport of mitochondrion', 'B-1 B cell homeostasis', 'bone mineralization', 'cardiac ventricle morphogenesis', 'cellular glucose homeostasis', 'cellular iron ion homeostasis', 'cellular response to hypoxia', 'cellular response to interleukin-1', 'cellular response to virus', 'cerebral cortex development', 'chondrocyte differentiation', 'collagen metabolic process', 'connective tissue replacement involved in inflammatory response wound healing', 'digestive tract morphogenesis', 'dopaminergic neuron differentiation', 'elastin metabolic process', 'embryonic hemopoiesis', 'embryonic placenta development', 'epithelial cell differentiation involved in mammary gland alveolus development', 'epithelial to mesenchymal transition', 'glandular epithelial cell maturation', 'heart looping', 'hemoglobin biosynthetic process', 'hypoxia-inducible factor-1alpha signaling pathway', 'insulin secretion involved in cellular response to glucose stimulus', 'intestinal epithelial cell maturation', 'iris morphogenesis', 'lactate metabolic process', 'lactation', 'mesenchymal cell apoptotic process', 'muscle cell cellular homeostasis', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'negative regulation of growth', 'negative regulation of mesenchymal cell apoptotic process', 'negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of thymocyte apoptotic process', 'negative regulation of TOR signaling', 'neural crest cell migration', 'neural fold elevation formation', 'neuroblast proliferation', 'neuron apoptotic process', 'outflow tract morphogenesis', 'oxygen homeostasis', 'positive regulation of angiogenesis', 'positive regulation of autophagy of mitochondrion', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of chemokine production', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of erythrocyte differentiation', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of hormone biosynthetic process', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of macroautophagy', 'positive regulation of miRNA transcription', 'positive regulation of neuroblast proliferation', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of signaling receptor activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of aerobic respiration', 'regulation of gene expression', 'regulation of glycolytic process', 'regulation of protein neddylation', 'regulation of transcription by RNA polymerase II', 'regulation of transcription from RNA polymerase II promoter in response to oxidative stress', 'regulation of transcription, DNA-templated', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to iron ion', 'response to muscle activity', 'response to reactive oxygen species', 'retina vasculature development in camera-type eye', 'signal transduction', 'TOR signaling', 'vascular endothelial growth factor production', 'visual learning']
Cytochrome c oxidase assembly factor 6 homolog
58
Cytochrome c oxidase assembly factor 6 homolog
59
8.4
68
0.18
Q5JTJ3Q5JTJ3['mitochondrial ATP synthesis coupled electron transport', 'plasma membrane ATP synthesis coupled electron transport', 'respiratory chain complex IV assembly']['mitochondrial ATP synthesis coupled electron transport', 'plasma membrane ATP synthesis coupled electron transport', 'respiratory chain complex IV assembly']
Major prion protein
214
Major prion protein
214
7.5
60
0.22
P04156P04156['activation of protein kinase activity', 'calcium-mediated signaling using intracellular calcium source', 'cell cycle', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to copper ion', 'cellular response to xenobiotic stimulus', 'dendritic spine maintenance', 'learning or memory', 'long-term memory', 'negative regulation of activated T cell proliferation', 'negative regulation of amyloid precursor protein catabolic process', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of calcineurin-NFAT signaling cascade', 'negative regulation of dendritic spine maintenance', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-17 production', 'negative regulation of interleukin-2 production', 'negative regulation of long-term synaptic potentiation', 'negative regulation of protein phosphorylation', 'negative regulation of protein processing', 'negative regulation of T cell receptor signaling pathway', 'neuron projection maintenance', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein targeting to membrane', 'positive regulation of protein tyrosine kinase activity', 'protein destabilization', 'protein homooligomerization', 'regulation of calcium ion import across plasma membrane', 'regulation of glutamate receptor signaling pathway', 'regulation of intracellular calcium activated chloride channel activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of potassium ion transmembrane transport', 'response to amyloid-beta', 'response to cadmium ion', 'response to oxidative stress']['activation of protein kinase activity', 'calcium-mediated signaling using intracellular calcium source', 'cell cycle', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to copper ion', 'cellular response to xenobiotic stimulus', 'dendritic spine maintenance', 'learning or memory', 'long-term memory', 'negative regulation of activated T cell proliferation', 'negative regulation of amyloid precursor protein catabolic process', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of calcineurin-NFAT signaling cascade', 'negative regulation of dendritic spine maintenance', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-17 production', 'negative regulation of interleukin-2 production', 'negative regulation of long-term synaptic potentiation', 'negative regulation of protein phosphorylation', 'negative regulation of protein processing', 'negative regulation of T cell receptor signaling pathway', 'neuron projection maintenance', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein targeting to membrane', 'positive regulation of protein tyrosine kinase activity', 'protein destabilization', 'protein homooligomerization', 'regulation of calcium ion import across plasma membrane', 'regulation of glutamate receptor signaling pathway', 'regulation of intracellular calcium activated chloride channel activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of potassium ion transmembrane transport', 'response to amyloid-beta', 'response to cadmium ion', 'response to oxidative stress']
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
89
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
89
8.7
nan
nan
O14595O14595['negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of protein phosphorylation', 'protein dephosphorylation']['negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of protein phosphorylation', 'protein dephosphorylation']
Ubiquitin carboxyl-terminal hydrolase 2
485
Polyubiquitin-B
2
8.8
68
0.17
O75604P0CG47['cell cycle', 'circadian behavior', 'circadian regulation of gene expression', 'entrainment of circadian clock by photoperiod', 'locomotor rhythm', 'muscle organ development', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of mitotic cell cycle', 'protein deubiquitination', 'protein stabilization', 'regulation of signal transduction by p53 class mediator', 'ubiquitin-dependent protein catabolic process']['energy homeostasis', 'fat pad development', 'female gonad development', 'female meiosis I', 'hypothalamus gonadotrophin-releasing hormone neuron development', 'male meiosis I', 'mitochondrion transport along microtubule', 'modification-dependent protein catabolic process', 'neuron projection morphogenesis', 'positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'positive regulation of protein monoubiquitination', 'positive regulation of protein ubiquitination', 'protein ubiquitination', 'regulation of mitochondrial membrane potential', 'regulation of neuron death', 'regulation of proteasomal protein catabolic process', 'seminiferous tubule development']
Neutrophil defensin 3
66
Neutrophil defensin 3
66
9.4
nan
nan
P59666P59666['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to virus', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing of cells of another organism', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to virus', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing of cells of another organism', 'membrane disruption in another organism']
T cell receptor alpha chain constant
157
Human nkt tcr beta chain
176
2.0
71
0.69
P01848K7N5M4['adaptive immune response', 'alpha-beta T cell activation', 'response to bacterium', 'T cell receptor signaling pathway'][]
DNA polymerase theta
2527
DNA polymerase theta
2527
7.3
nan
nan
O75417O75417['base-excision repair', 'cellular response to DNA damage stimulus', 'DNA repair', 'DNA-templated DNA replication', 'double-strand break repair', 'double-strand break repair via alternative nonhomologous end joining', 'negative regulation of double-strand break repair via homologous recombination', 'protein homooligomerization', 'somatic hypermutation of immunoglobulin genes']['base-excision repair', 'cellular response to DNA damage stimulus', 'DNA repair', 'DNA-templated DNA replication', 'double-strand break repair', 'double-strand break repair via alternative nonhomologous end joining', 'negative regulation of double-strand break repair via homologous recombination', 'protein homooligomerization', 'somatic hypermutation of immunoglobulin genes']
Low affinity immunoglobulin epsilon Fc receptor
160
Low affinity immunoglobulin epsilon Fc receptor
160
7.5
nan
nan
P06734P06734['positive regulation of humoral immune response mediated by circulating immunoglobulin', 'positive regulation of killing of cells of another organism', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of nitric-oxide synthase biosynthetic process']['positive regulation of humoral immune response mediated by circulating immunoglobulin', 'positive regulation of killing of cells of another organism', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of nitric-oxide synthase biosynthetic process']
Insulin
109
Insulin
22
6.0
49
0.34
P01308P01308['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']
Cartilage oligomeric matrix protein
71
Cartilage oligomeric matrix protein
71
5.8
nan
nan
Q9R0G6Q9R0G6['apoptotic process', 'artery morphogenesis', 'blood coagulation', 'BMP signaling pathway', 'bone growth', 'bone mineralization', 'bone morphogenesis', 'cartilage development', 'cartilage homeostasis', 'chondrocyte development', 'chondrocyte proliferation', 'collagen fibril organization', 'endochondral bone growth', 'growth plate cartilage development', 'limb development', 'multicellular organism aging', 'multicellular organism growth', 'muscle cell development', 'musculoskeletal movement', 'negative regulation of apoptotic process', 'negative regulation of hemostasis', 'neuromuscular process', 'ossification', 'platelet aggregation', 'positive regulation of chondrocyte proliferation', 'protein homooligomerization', 'protein processing', 'protein secretion', 'regulation of bone mineralization', 'regulation of gene expression', 'response to unfolded protein', 'skeletal system development', 'skin development', 'tendon development', 'vascular associated smooth muscle cell development', 'vascular associated smooth muscle contraction']['apoptotic process', 'artery morphogenesis', 'blood coagulation', 'BMP signaling pathway', 'bone growth', 'bone mineralization', 'bone morphogenesis', 'cartilage development', 'cartilage homeostasis', 'chondrocyte development', 'chondrocyte proliferation', 'collagen fibril organization', 'endochondral bone growth', 'growth plate cartilage development', 'limb development', 'multicellular organism aging', 'multicellular organism growth', 'muscle cell development', 'musculoskeletal movement', 'negative regulation of apoptotic process', 'negative regulation of hemostasis', 'neuromuscular process', 'ossification', 'platelet aggregation', 'positive regulation of chondrocyte proliferation', 'protein homooligomerization', 'protein processing', 'protein secretion', 'regulation of bone mineralization', 'regulation of gene expression', 'response to unfolded protein', 'skeletal system development', 'skin development', 'tendon development', 'vascular associated smooth muscle cell development', 'vascular associated smooth muscle contraction']
Insulin
95
Insulin
4
9.4
55
0.19
P01308P01308['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']
Uncharacterized protein DKFZp686I04196
97
Tumor necrosis factor receptor superfamily member 13C
19
9.8
63
0.16
Q6N093Q96RJ3[]['adaptive immune response', 'B cell costimulation', 'positive regulation of B cell proliferation', 'positive regulation of T cell proliferation', 'T cell costimulation', 'tumor necrosis factor-mediated signaling pathway']
Immunoglobulin heavy constant gamma 1
112
Immunoglobulin heavy constant gamma 1
112
2.0
nan
nan
P01857P01857['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
Resistin-like beta
25
Resistin-like beta
25
2.0
nan
nan
Q99P86Q99P86['response to bacterium']['response to bacterium']
Immunoglobulin heavy constant gamma 1
349
Immunoglobulin heavy constant gamma 1
250
8.2
85
0.14
P01857P01857['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
Endothelin-1
53
Endothelin-1
53
9.4
nan
nan
P05305P05305['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'artery smooth muscle contraction', 'axon extension', 'axonogenesis involved in innervation', 'body fluid secretion', 'branching involved in blood vessel morphogenesis', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cardiac neural crest cell migration involved in outflow tract morphogenesis', 'cartilage development', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to calcium ion', 'cellular response to fatty acid', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to human chorionic gonadotropin stimulus', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to luteinizing hormone stimulus', 'cellular response to mineralocorticoid stimulus', 'cellular response to organic substance', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to xenobiotic stimulus', 'dorsal/ventral pattern formation', 'embryonic heart tube development', 'endothelin receptor signaling pathway', 'endothelin receptor signaling pathway involved in heart process', 'epithelial fluid transport', 'ERK1 and ERK2 cascade', 'G protein-coupled receptor signaling pathway', 'histamine secretion', 'I-kappaB kinase/NF-kappaB signaling', 'in utero embryonic development', 'inositol phosphate-mediated signaling', 'leukocyte activation', 'maternal process involved in parturition', 'meiotic cell cycle process involved in oocyte maturation', 'membrane depolarization', 'middle ear morphogenesis', 'mitochondrion organization', 'multicellular organism aging', 'negative regulation of blood coagulation', 'negative regulation of gene expression', 'negative regulation of hormone secretion', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein metabolic process', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'neural crest cell fate commitment', 'nitric oxide transport', 'noradrenergic neuron differentiation', 'peptide hormone secretion', 'pharyngeal arch artery morphogenesis', 'phosphatidylinositol 3-kinase signaling', 'phospholipase D-activating G protein-coupled receptor signaling pathway', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cation channel activity', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell size', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell migration', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of JUN kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of odontogenesis', 'positive regulation of prostaglandin secretion', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'positive regulation of renal sodium excretion', 'positive regulation of sarcomere organization', 'positive regulation of signaling receptor activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'prostaglandin biosynthetic process', 'protein kinase A signaling', 'protein kinase C deactivation', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'regulation of glucose transmembrane transport', 'regulation of pH', 'regulation of sensory perception of pain', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'renal sodium ion absorption', 'respiratory gaseous exchange by respiratory system', 'response to activity', 'response to amino acid', 'response to amphetamine', 'response to dexamethasone', 'response to leptin', 'response to lipopolysaccharide', 'response to muscle stretch', 'response to nicotine', 'response to ozone', 'response to prostaglandin F', 'response to salt', 'response to testosterone', 'rhythmic excitation', 'semaphorin-plexin signaling pathway involved in axon guidance', 'sensory perception of pain', 'superoxide anion generation', 'sympathetic neuron axon guidance', 'thyroid gland development', 'transcription by RNA polymerase II', 'vasoconstriction', 'vein smooth muscle contraction']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'artery smooth muscle contraction', 'axon extension', 'axonogenesis involved in innervation', 'body fluid secretion', 'branching involved in blood vessel morphogenesis', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cardiac neural crest cell migration involved in outflow tract morphogenesis', 'cartilage development', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to calcium ion', 'cellular response to fatty acid', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to human chorionic gonadotropin stimulus', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to luteinizing hormone stimulus', 'cellular response to mineralocorticoid stimulus', 'cellular response to organic substance', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to xenobiotic stimulus', 'dorsal/ventral pattern formation', 'embryonic heart tube development', 'endothelin receptor signaling pathway', 'endothelin receptor signaling pathway involved in heart process', 'epithelial fluid transport', 'ERK1 and ERK2 cascade', 'G protein-coupled receptor signaling pathway', 'histamine secretion', 'I-kappaB kinase/NF-kappaB signaling', 'in utero embryonic development', 'inositol phosphate-mediated signaling', 'leukocyte activation', 'maternal process involved in parturition', 'meiotic cell cycle process involved in oocyte maturation', 'membrane depolarization', 'middle ear morphogenesis', 'mitochondrion organization', 'multicellular organism aging', 'negative regulation of blood coagulation', 'negative regulation of gene expression', 'negative regulation of hormone secretion', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein metabolic process', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'neural crest cell fate commitment', 'nitric oxide transport', 'noradrenergic neuron differentiation', 'peptide hormone secretion', 'pharyngeal arch artery morphogenesis', 'phosphatidylinositol 3-kinase signaling', 'phospholipase D-activating G protein-coupled receptor signaling pathway', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cation channel activity', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell size', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell migration', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of JUN kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of odontogenesis', 'positive regulation of prostaglandin secretion', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'positive regulation of renal sodium excretion', 'positive regulation of sarcomere organization', 'positive regulation of signaling receptor activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'prostaglandin biosynthetic process', 'protein kinase A signaling', 'protein kinase C deactivation', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'regulation of glucose transmembrane transport', 'regulation of pH', 'regulation of sensory perception of pain', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'renal sodium ion absorption', 'respiratory gaseous exchange by respiratory system', 'response to activity', 'response to amino acid', 'response to amphetamine', 'response to dexamethasone', 'response to leptin', 'response to lipopolysaccharide', 'response to muscle stretch', 'response to nicotine', 'response to ozone', 'response to prostaglandin F', 'response to salt', 'response to testosterone', 'rhythmic excitation', 'semaphorin-plexin signaling pathway involved in axon guidance', 'sensory perception of pain', 'superoxide anion generation', 'sympathetic neuron axon guidance', 'thyroid gland development', 'transcription by RNA polymerase II', 'vasoconstriction', 'vein smooth muscle contraction']
Nitric oxide synthase, brain
302
Nitric oxide synthase, brain
302
4.3
nan
nan
P29475P29475['arginine catabolic process', 'cell redox homeostasis', 'cellular response to growth factor stimulus', 'multicellular organismal response to stress', 'muscle contraction', 'myoblast fusion', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of calcium ion transport into cytosol', 'negative regulation of hydrolase activity', 'negative regulation of potassium ion transport', 'negative regulation of serotonin uptake', 'neurotransmitter biosynthetic process', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of guanylate cyclase activity', 'positive regulation of histone acetylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of sodium ion transmembrane transport', 'positive regulation of the force of heart contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of calcium ion transmembrane transport via high voltage-gated calcium channel', 'regulation of cardiac muscle contraction', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of sodium ion transport', 'response to heat', 'response to hormone', 'response to hypoxia', 'response to lipopolysaccharide', 'retrograde trans-synaptic signaling by nitric oxide', 'striated muscle contraction', 'vasodilation', 'xenobiotic catabolic process']['arginine catabolic process', 'cell redox homeostasis', 'cellular response to growth factor stimulus', 'multicellular organismal response to stress', 'muscle contraction', 'myoblast fusion', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of calcium ion transport into cytosol', 'negative regulation of hydrolase activity', 'negative regulation of potassium ion transport', 'negative regulation of serotonin uptake', 'neurotransmitter biosynthetic process', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of guanylate cyclase activity', 'positive regulation of histone acetylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of sodium ion transmembrane transport', 'positive regulation of the force of heart contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of calcium ion transmembrane transport via high voltage-gated calcium channel', 'regulation of cardiac muscle contraction', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of sodium ion transport', 'response to heat', 'response to hormone', 'response to hypoxia', 'response to lipopolysaccharide', 'retrograde trans-synaptic signaling by nitric oxide', 'striated muscle contraction', 'vasodilation', 'xenobiotic catabolic process']
CD320 antigen
89
CD320 antigen
89
9.3
nan
nan
Q9NPF0Q9NPF0['B cell costimulation', 'cobalamin metabolic process', 'cobalamin transport', 'positive regulation of B cell proliferation', 'regulation of vitamin metabolic process']['B cell costimulation', 'cobalamin metabolic process', 'cobalamin transport', 'positive regulation of B cell proliferation', 'regulation of vitamin metabolic process']
Insulin
100
Insulin
4
8.2
53
0.23
P01308P01308['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']
Cyclin-T1
261
Cyclin-T1
261
9.2
nan
nan
O60563O60563['cell cycle', 'cell division', 'phosphorylation of RNA polymerase II C-terminal domain serine 2 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter', 'phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter', 'positive regulation by host of viral transcription', 'positive regulation of DNA-templated transcription, elongation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription elongation from RNA polymerase II promoter', 'protein phosphorylation', 'regulation of cyclin-dependent protein serine/threonine kinase activity', 'regulation of transcription by RNA polymerase II', 'response to xenobiotic stimulus', 'transcription by RNA polymerase II']['cell cycle', 'cell division', 'phosphorylation of RNA polymerase II C-terminal domain serine 2 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter', 'phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter', 'positive regulation by host of viral transcription', 'positive regulation of DNA-templated transcription, elongation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription elongation from RNA polymerase II promoter', 'protein phosphorylation', 'regulation of cyclin-dependent protein serine/threonine kinase activity', 'regulation of transcription by RNA polymerase II', 'response to xenobiotic stimulus', 'transcription by RNA polymerase II']
Endothelial PAS domain-containing protein 1
542
von Hippel-Lindau disease tumor suppressor
77
2.0
nan
nan
Q99814P40337['angiogenesis', 'blood vessel remodeling', 'cellular response to hypoxia', 'embryonic placenta development', 'epithelial cell maturation', 'erythrocyte differentiation', 'iron ion homeostasis', 'lung development', 'mitochondrion organization', 'mRNA transcription by RNA polymerase II', 'myoblast fate commitment', 'norepinephrine metabolic process', 'positive regulation of cold-induced thermogenesis', 'positive regulation of transcription by RNA polymerase II', 'regulation of heart rate', 'regulation of protein neddylation', 'regulation of transcription by RNA polymerase II', 'regulation of transcription from RNA polymerase II promoter in response to oxidative stress', 'response to hypoxia', 'signal transduction', 'surfactant homeostasis', 'visual perception']['cell morphogenesis', 'negative regulation of apoptotic process', 'negative regulation of cell population proliferation', 'negative regulation of gene expression', 'negative regulation of receptor signaling pathway via JAK-STAT', 'negative regulation of transcription elongation from RNA polymerase II promoter', 'negative regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of cell differentiation', 'positive regulation of transcription, DNA-templated', 'protein stabilization', 'protein ubiquitination', 'proteolysis', 'regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'regulation of transcription, DNA-templated']
Human nkt tcr beta chain
176
TRA@ protein
167
2.0
75
0.66
K7N5M4Q6PJ56[][]
T-cell receptor, sp3.4 alpha chain
161
TRB protein
171
2.0
73
0.67
K7N5N2A0A0C4ZKA8[][]
PRSS3 protein
200
Amyloid-beta A4 protein
34
8.4
100
0.12
Q8N2U3H7C0V9['proteolysis']['nervous system development']
Guanylate cyclase soluble subunit alpha-1
595
Guanylate cyclase soluble subunit beta-1
476
3.8
78
0.34
Q02108Q02153['blood circulation', 'cGMP biosynthetic process', 'cGMP-mediated signaling', 'nitric oxide mediated signal transduction', 'positive regulation of nitric oxide mediated signal transduction', 'regulation of blood pressure', 'relaxation of vascular associated smooth muscle', 'response to oxygen levels', 'retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission']['blood circulation', 'cellular response to nitric oxide', 'cGMP biosynthetic process', 'cGMP-mediated signaling', 'nitric oxide mediated signal transduction', 'nitric oxide-cGMP-mediated signaling pathway', 'response to oxygen levels', 'trans-synaptic signaling by nitric oxide, modulating synaptic transmission']
Integrin alpha-2
169
Integrin alpha-2
169
2.0
63
0.78
P17301P17301['animal organ morphogenesis', 'blood coagulation', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell population proliferation', 'cell-cell adhesion', 'cell-matrix adhesion', 'cell-substrate adhesion', 'cellular response to estradiol stimulus', 'cellular response to mechanical stimulus', 'collagen-activated signaling pathway', 'detection of mechanical stimulus involved in sensory perception of pain', 'establishment of protein localization', 'female pregnancy', 'focal adhesion assembly', 'hepatocyte differentiation', 'hypotonic response', 'integrin-mediated signaling pathway', 'mammary gland development', 'mesodermal cell differentiation', 'positive regulation of alkaline phosphatase activity', 'positive regulation of cell adhesion', 'positive regulation of cell projection organization', 'positive regulation of collagen binding', 'positive regulation of collagen biosynthetic process', 'positive regulation of DNA binding', 'positive regulation of epithelial cell migration', 'positive regulation of inflammatory response', 'positive regulation of leukocyte migration', 'positive regulation of phagocytosis, engulfment', 'positive regulation of positive chemotaxis', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of translation', 'positive regulation of transmission of nerve impulse', 'response to amine', 'response to hypoxia', 'response to L-ascorbic acid', 'response to muscle activity', 'response to parathyroid hormone', 'response to xenobiotic stimulus', 'skin morphogenesis', 'substrate-dependent cell migration']['animal organ morphogenesis', 'blood coagulation', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell population proliferation', 'cell-cell adhesion', 'cell-matrix adhesion', 'cell-substrate adhesion', 'cellular response to estradiol stimulus', 'cellular response to mechanical stimulus', 'collagen-activated signaling pathway', 'detection of mechanical stimulus involved in sensory perception of pain', 'establishment of protein localization', 'female pregnancy', 'focal adhesion assembly', 'hepatocyte differentiation', 'hypotonic response', 'integrin-mediated signaling pathway', 'mammary gland development', 'mesodermal cell differentiation', 'positive regulation of alkaline phosphatase activity', 'positive regulation of cell adhesion', 'positive regulation of cell projection organization', 'positive regulation of collagen binding', 'positive regulation of collagen biosynthetic process', 'positive regulation of DNA binding', 'positive regulation of epithelial cell migration', 'positive regulation of inflammatory response', 'positive regulation of leukocyte migration', 'positive regulation of phagocytosis, engulfment', 'positive regulation of positive chemotaxis', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of translation', 'positive regulation of transmission of nerve impulse', 'response to amine', 'response to hypoxia', 'response to L-ascorbic acid', 'response to muscle activity', 'response to parathyroid hormone', 'response to xenobiotic stimulus', 'skin morphogenesis', 'substrate-dependent cell migration']
Myocilin
171
Myocilin
171
2.0
nan
nan
O70624O70624['bone development', 'clustering of voltage-gated sodium channels', 'ERBB2-ERBB3 signaling pathway', 'myelination in peripheral nervous system', 'negative regulation of cell-matrix adhesion', 'negative regulation of Rho protein signal transduction', 'negative regulation of stress fiber assembly', 'neuron projection development', 'non-canonical Wnt signaling pathway via JNK cascade', 'osteoblast differentiation', 'positive regulation of cell migration', 'positive regulation of focal adhesion assembly', 'positive regulation of mitochondrial depolarization', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of stress fiber assembly', 'positive regulation of substrate adhesion-dependent cell spreading', 'regulation of MAPK cascade', 'signal transduction', 'skeletal muscle hypertrophy']['bone development', 'clustering of voltage-gated sodium channels', 'ERBB2-ERBB3 signaling pathway', 'myelination in peripheral nervous system', 'negative regulation of cell-matrix adhesion', 'negative regulation of Rho protein signal transduction', 'negative regulation of stress fiber assembly', 'neuron projection development', 'non-canonical Wnt signaling pathway via JNK cascade', 'osteoblast differentiation', 'positive regulation of cell migration', 'positive regulation of focal adhesion assembly', 'positive regulation of mitochondrial depolarization', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of stress fiber assembly', 'positive regulation of substrate adhesion-dependent cell spreading', 'regulation of MAPK cascade', 'signal transduction', 'skeletal muscle hypertrophy']
Human nkt tcr alpha chain
80
Human nkt tcr beta chain
176
9.8
66
0.15
K7N5M3K7N5M4[][]
Immunoglobulin heavy constant mu
215
Immunoglobulin heavy constant mu
215
2.0
nan
nan
P01873P01873['adaptive immune response', 'antibacterial humoral response', 'antigen processing and presentation', 'B cell activation', 'B cell affinity maturation', 'B cell proliferation', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'early endosome to late endosome transport', 'humoral immune response mediated by circulating immunoglobulin', 'immunoglobulin mediated immune response', 'innate immune response', 'MAPK cascade', 'peptidyl-tyrosine phosphorylation', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of B cell proliferation', 'positive regulation of endocytosis', 'positive regulation of immune response', 'positive regulation of MAPK cascade', 'positive regulation of peptidyl-tyrosine phosphorylation', 'regulation of cell morphogenesis', 'regulation of immunoglobulin production']['adaptive immune response', 'antibacterial humoral response', 'antigen processing and presentation', 'B cell activation', 'B cell affinity maturation', 'B cell proliferation', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'early endosome to late endosome transport', 'humoral immune response mediated by circulating immunoglobulin', 'immunoglobulin mediated immune response', 'innate immune response', 'MAPK cascade', 'peptidyl-tyrosine phosphorylation', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of B cell proliferation', 'positive regulation of endocytosis', 'positive regulation of immune response', 'positive regulation of MAPK cascade', 'positive regulation of peptidyl-tyrosine phosphorylation', 'regulation of cell morphogenesis', 'regulation of immunoglobulin production']
PRSS3 protein
200
Amyloid-beta A4 protein
17
10.0
103
0.1
Q8N2U3H7C0V9['proteolysis']['nervous system development']
Immunoglobulin gamma-1 heavy chain
231
Immunoglobulin gamma-1 heavy chain
231
2.0
nan
nan
P0DOX5P0DOX5['adaptive immune response']['adaptive immune response']
Neutrophil defensin 1
66
Neutrophil defensin 1
68
7.1
64
0.22
P59665P59665['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']
Glutamate receptor 3
312
Glutamate receptor 3
85
9.3
nan
nan
P19492P19492['regulation of receptor recycling', 'response to fungicide', 'response to lithium ion']['regulation of receptor recycling', 'response to fungicide', 'response to lithium ion']
Beta-microseminoprotein
22
Beta-microseminoprotein
22
8.3
57
0.21
P08118P08118[][]
Leukocyte immunoglobulin-like receptor subfamily A member 2
195
Leukocyte immunoglobulin-like receptor subfamily A member 2
142
10.0
80
0.13
Q8N149Q8N149['cytokine-mediated signaling pathway', 'defense response', 'innate immune response', 'innate immune response activating cell surface receptor signaling pathway', 'negative regulation of lipopolysaccharide-mediated signaling pathway', 'negative regulation of toll-like receptor 4 signaling pathway', 'neutrophil activation involved in immune response', 'positive regulation of calcium ion transport', 'positive regulation of cell activation', 'positive regulation of granulocyte colony-stimulating factor production', 'positive regulation of granulocyte macrophage colony-stimulating factor production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of tumor necrosis factor production', 'signal transduction']['cytokine-mediated signaling pathway', 'defense response', 'innate immune response', 'innate immune response activating cell surface receptor signaling pathway', 'negative regulation of lipopolysaccharide-mediated signaling pathway', 'negative regulation of toll-like receptor 4 signaling pathway', 'neutrophil activation involved in immune response', 'positive regulation of calcium ion transport', 'positive regulation of cell activation', 'positive regulation of granulocyte colony-stimulating factor production', 'positive regulation of granulocyte macrophage colony-stimulating factor production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of tumor necrosis factor production', 'signal transduction']
Integrin beta-4
1629
Dystonin
1082
2.0
46
1.06
P16144Q03001['autophagy', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell motility', 'cell-matrix adhesion', 'filopodium assembly', 'hemidesmosome assembly', 'integrin-mediated signaling pathway', 'mesodermal cell differentiation', 'nail development', 'peripheral nervous system myelin formation', 'response to wounding', 'skin morphogenesis', 'trophoblast cell migration']['cell adhesion', 'cell motility', 'cytoplasmic microtubule organization', 'cytoskeleton organization', 'hemidesmosome assembly', 'integrin-mediated signaling pathway', 'intermediate filament cytoskeleton organization', 'maintenance of cell polarity', 'microtubule cytoskeleton organization', 'response to wounding', 'retrograde axonal transport', 'wound healing']
Hepcidin
73
Neutrophil gelatinase-associated lipocalin
76
3.4
80
0.37
P81172P80188['acute-phase response', 'aging', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular iron ion homeostasis', 'cellular response to bile acid', 'cellular response to interleukin-6', 'cellular response to lipopolysaccharide', 'cellular response to tumor necrosis factor', 'cellular response to X-ray', 'defense response to bacterium', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'establishment of localization in cell', 'immune response', 'iron ion transmembrane transport', 'killing of cells of another organism', 'liver regeneration', 'macrophage activation', 'multicellular organismal iron ion homeostasis', 'myeloid cell homeostasis', 'negative regulation of bone resorption', 'negative regulation of inflammatory response', 'negative regulation of intestinal absorption', 'negative regulation of ion transmembrane transporter activity', 'negative regulation of iron export across plasma membrane', 'negative regulation of iron ion transmembrane transport', 'negative regulation of iron ion transmembrane transporter activity', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of macrophage activation', 'positive regulation of protein catabolic process', 'positive regulation of protein polyubiquitination', 'positive regulation of receptor catabolic process', 'positive regulation of receptor internalization', 'positive regulation of transcription by RNA polymerase II', 'protein catabolic process', 'receptor signaling pathway via JAK-STAT', 'response to erythropoietin', 'response to ethanol', 'response to iron ion', 'response to iron ion starvation', 'response to vitamin A', 'response to zinc ion', 'transcription by RNA polymerase II']['apoptotic process', 'defense response to bacterium', 'innate immune response', 'positive regulation of cold-induced thermogenesis', 'sequestering of iron ion', 'siderophore transport']
Neutrophil defensin 3
68
Neutrophil defensin 3
66
8.3
nan
nan
P59666P59666['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to virus', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing of cells of another organism', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to virus', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing of cells of another organism', 'membrane disruption in another organism']
Immunoglobulin heavy constant gamma 1
308
Immunoglobulin heavy constant gamma 1
349
9.9
79
0.13
P01857P01857['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
Oxidized low-density lipoprotein receptor 1
144
Oxidized low-density lipoprotein receptor 1
144
10.0
66
0.15
P78380P78380['blood circulation', 'cell death', 'immune system process', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipoprotein metabolic process', 'proteolysis']['blood circulation', 'cell death', 'immune system process', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipoprotein metabolic process', 'proteolysis']
Guanine nucleotide exchange factor DBS
952
Guanine nucleotide exchange factor DBS
952
6.8
41
0.36
Q64096Q64096['positive regulation of Rho protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'Rho protein signal transduction']['positive regulation of Rho protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'Rho protein signal transduction']
Lymphocyte antigen 6 complex locus protein G6d
96
Lymphocyte antigen 6 complex locus protein G6d
96
3.7
73
0.37
O95868O95868['acetylcholine receptor signaling pathway']['acetylcholine receptor signaling pathway']
Vam6/Vps39-like protein
852
Vam6/Vps39-like protein
852
7.1
51
0.27
Q96JC1Q96JC1['autophagosome-lysosome fusion', 'autophagy', 'endocytic recycling', 'endosomal vesicle fusion', 'endosome to lysosome transport', 'intracellular protein transport', 'late endosome to lysosome transport', 'regulation of SNARE complex assembly']['autophagosome-lysosome fusion', 'autophagy', 'endocytic recycling', 'endosomal vesicle fusion', 'endosome to lysosome transport', 'intracellular protein transport', 'late endosome to lysosome transport', 'regulation of SNARE complex assembly']
Caspase-3
220
Caspase-3
264
3.3
86
0.36
P42574P42574['anterior neural tube closure', 'apoptotic process', 'apoptotic signaling pathway', 'axonal fasciculation', 'B cell homeostasis', 'cell fate commitment', 'cellular response to DNA damage stimulus', 'cellular response to staurosporine', 'epithelial cell apoptotic process', 'erythrocyte differentiation', 'execution phase of apoptosis', 'fibroblast apoptotic process', 'glial cell apoptotic process', 'heart development', 'hippocampus development', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway in response to osmotic stress', 'keratinocyte differentiation', 'learning or memory', 'leukocyte apoptotic process', 'luteolysis', 'negative regulation of activated T cell proliferation', 'negative regulation of apoptotic process', 'negative regulation of B cell proliferation', 'neuron apoptotic process', 'neuron differentiation', 'neurotrophin TRK receptor signaling pathway', 'platelet formation', 'positive regulation of amyloid-beta formation', 'positive regulation of apoptotic DNA fragmentation', 'positive regulation of apoptotic process', 'positive regulation of neuron apoptotic process', 'protein catabolic process', 'protein processing', 'proteolysis', 'regulation of macroautophagy', 'regulation of protein stability', 'response to amino acid', 'response to antibiotic', 'response to cobalt ion', 'response to estradiol', 'response to glucocorticoid', 'response to glucose', 'response to hydrogen peroxide', 'response to hypoxia', 'response to lipopolysaccharide', 'response to nicotine', 'response to tumor necrosis factor', 'response to UV', 'response to X-ray', 'response to xenobiotic stimulus', 'sensory perception of sound', 'striated muscle cell differentiation', 'T cell homeostasis', 'wound healing']['anterior neural tube closure', 'apoptotic process', 'apoptotic signaling pathway', 'axonal fasciculation', 'B cell homeostasis', 'cell fate commitment', 'cellular response to DNA damage stimulus', 'cellular response to staurosporine', 'epithelial cell apoptotic process', 'erythrocyte differentiation', 'execution phase of apoptosis', 'fibroblast apoptotic process', 'glial cell apoptotic process', 'heart development', 'hippocampus development', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway in response to osmotic stress', 'keratinocyte differentiation', 'learning or memory', 'leukocyte apoptotic process', 'luteolysis', 'negative regulation of activated T cell proliferation', 'negative regulation of apoptotic process', 'negative regulation of B cell proliferation', 'neuron apoptotic process', 'neuron differentiation', 'neurotrophin TRK receptor signaling pathway', 'platelet formation', 'positive regulation of amyloid-beta formation', 'positive regulation of apoptotic DNA fragmentation', 'positive regulation of apoptotic process', 'positive regulation of neuron apoptotic process', 'protein catabolic process', 'protein processing', 'proteolysis', 'regulation of macroautophagy', 'regulation of protein stability', 'response to amino acid', 'response to antibiotic', 'response to cobalt ion', 'response to estradiol', 'response to glucocorticoid', 'response to glucose', 'response to hydrogen peroxide', 'response to hypoxia', 'response to lipopolysaccharide', 'response to nicotine', 'response to tumor necrosis factor', 'response to UV', 'response to X-ray', 'response to xenobiotic stimulus', 'sensory perception of sound', 'striated muscle cell differentiation', 'T cell homeostasis', 'wound healing']
PRSS3 protein
52
Amyloid-beta A4 protein
34
9.7
94
0.11
Q8N2U3H7C0V9['proteolysis']['nervous system development']
Spondin-1
182
Spondin-1
182
8.3
63
0.19
Q9HCB6Q9HCB6['cell adhesion', 'negative regulation of amyloid-beta formation', 'positive regulation of amyloid precursor protein catabolic process', 'positive regulation of protein binding', 'positive regulation of protein processing', 'protein processing']['cell adhesion', 'negative regulation of amyloid-beta formation', 'positive regulation of amyloid precursor protein catabolic process', 'positive regulation of protein binding', 'positive regulation of protein processing', 'protein processing']
Immunoglobulin heavy constant gamma 1
109
Immunoglobulin heavy constant gamma 1
112
9.3
nan
nan
P01857P01857['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
Prothrombin
336
Thrombomodulin
134
2.1
82
0.58
P00734P07204['acute-phase response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'blood coagulation', 'blood coagulation, common pathway', 'cell surface receptor signaling pathway', 'cytolysis by host of symbiont cells', 'fibrinolysis', 'negative regulation of astrocyte differentiation', 'negative regulation of blood coagulation', 'negative regulation of cytokine production involved in inflammatory response', 'negative regulation of fibrinolysis', 'negative regulation of platelet activation', 'negative regulation of proteolysis', 'neutrophil-mediated killing of gram-negative bacterium', 'platelet activation', 'positive regulation of blood coagulation', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of lipid kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to nucleus', 'positive regulation of protein phosphorylation', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of release of sequestered calcium ion into cytosol', 'proteolysis', 'regulation of blood coagulation', 'regulation of cell shape', 'regulation of cytosolic calcium ion concentration', 'response to wounding', 'zymogen activation']['blood coagulation', 'blood coagulation, common pathway', 'female pregnancy', 'negative regulation of blood coagulation', 'negative regulation of fibrinolysis', 'negative regulation of platelet activation', 'proteolysis', 'response to cAMP', 'response to lipopolysaccharide', 'response to X-ray', 'zymogen activation']
Cartilage oligomeric matrix protein
68
Cartilage oligomeric matrix protein
71
2.0
nan
nan
Q9R0G6Q9R0G6['apoptotic process', 'artery morphogenesis', 'blood coagulation', 'BMP signaling pathway', 'bone growth', 'bone mineralization', 'bone morphogenesis', 'cartilage development', 'cartilage homeostasis', 'chondrocyte development', 'chondrocyte proliferation', 'collagen fibril organization', 'endochondral bone growth', 'growth plate cartilage development', 'limb development', 'multicellular organism aging', 'multicellular organism growth', 'muscle cell development', 'musculoskeletal movement', 'negative regulation of apoptotic process', 'negative regulation of hemostasis', 'neuromuscular process', 'ossification', 'platelet aggregation', 'positive regulation of chondrocyte proliferation', 'protein homooligomerization', 'protein processing', 'protein secretion', 'regulation of bone mineralization', 'regulation of gene expression', 'response to unfolded protein', 'skeletal system development', 'skin development', 'tendon development', 'vascular associated smooth muscle cell development', 'vascular associated smooth muscle contraction']['apoptotic process', 'artery morphogenesis', 'blood coagulation', 'BMP signaling pathway', 'bone growth', 'bone mineralization', 'bone morphogenesis', 'cartilage development', 'cartilage homeostasis', 'chondrocyte development', 'chondrocyte proliferation', 'collagen fibril organization', 'endochondral bone growth', 'growth plate cartilage development', 'limb development', 'multicellular organism aging', 'multicellular organism growth', 'muscle cell development', 'musculoskeletal movement', 'negative regulation of apoptotic process', 'negative regulation of hemostasis', 'neuromuscular process', 'ossification', 'platelet aggregation', 'positive regulation of chondrocyte proliferation', 'protein homooligomerization', 'protein processing', 'protein secretion', 'regulation of bone mineralization', 'regulation of gene expression', 'response to unfolded protein', 'skeletal system development', 'skin development', 'tendon development', 'vascular associated smooth muscle cell development', 'vascular associated smooth muscle contraction']
Phosphoinositide 3-kinase adapter protein 1
284
Phosphoinositide 3-kinase adapter protein 1
284
7.4
nan
nan
Q6ZUJ8Q6ZUJ8['positive regulation of phosphatidylinositol 3-kinase signaling', 'regulation of inflammatory response', 'toll-like receptor 2 signaling pathway', 'toll-like receptor 4 signaling pathway', 'toll-like receptor 7 signaling pathway', 'toll-like receptor 9 signaling pathway']['positive regulation of phosphatidylinositol 3-kinase signaling', 'regulation of inflammatory response', 'toll-like receptor 2 signaling pathway', 'toll-like receptor 4 signaling pathway', 'toll-like receptor 7 signaling pathway', 'toll-like receptor 9 signaling pathway']
Activated CDC42 kinase 1
119
Activated CDC42 kinase 1
119
6.0
70
0.24
Q07912Q07912['cell differentiation', 'cell surface receptor signaling pathway', 'endocytosis', 'innate immune response', 'phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'regulation of clathrin-dependent endocytosis', 'small GTPase mediated signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway']['cell differentiation', 'cell surface receptor signaling pathway', 'endocytosis', 'innate immune response', 'phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'regulation of clathrin-dependent endocytosis', 'small GTPase mediated signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Caspase-3
264
Caspase-3
184
9.7
91
0.11
P42574P42574['anterior neural tube closure', 'apoptotic process', 'apoptotic signaling pathway', 'axonal fasciculation', 'B cell homeostasis', 'cell fate commitment', 'cellular response to DNA damage stimulus', 'cellular response to staurosporine', 'epithelial cell apoptotic process', 'erythrocyte differentiation', 'execution phase of apoptosis', 'fibroblast apoptotic process', 'glial cell apoptotic process', 'heart development', 'hippocampus development', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway in response to osmotic stress', 'keratinocyte differentiation', 'learning or memory', 'leukocyte apoptotic process', 'luteolysis', 'negative regulation of activated T cell proliferation', 'negative regulation of apoptotic process', 'negative regulation of B cell proliferation', 'neuron apoptotic process', 'neuron differentiation', 'neurotrophin TRK receptor signaling pathway', 'platelet formation', 'positive regulation of amyloid-beta formation', 'positive regulation of apoptotic DNA fragmentation', 'positive regulation of apoptotic process', 'positive regulation of neuron apoptotic process', 'protein catabolic process', 'protein processing', 'proteolysis', 'regulation of macroautophagy', 'regulation of protein stability', 'response to amino acid', 'response to antibiotic', 'response to cobalt ion', 'response to estradiol', 'response to glucocorticoid', 'response to glucose', 'response to hydrogen peroxide', 'response to hypoxia', 'response to lipopolysaccharide', 'response to nicotine', 'response to tumor necrosis factor', 'response to UV', 'response to X-ray', 'response to xenobiotic stimulus', 'sensory perception of sound', 'striated muscle cell differentiation', 'T cell homeostasis', 'wound healing']['anterior neural tube closure', 'apoptotic process', 'apoptotic signaling pathway', 'axonal fasciculation', 'B cell homeostasis', 'cell fate commitment', 'cellular response to DNA damage stimulus', 'cellular response to staurosporine', 'epithelial cell apoptotic process', 'erythrocyte differentiation', 'execution phase of apoptosis', 'fibroblast apoptotic process', 'glial cell apoptotic process', 'heart development', 'hippocampus development', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway in response to osmotic stress', 'keratinocyte differentiation', 'learning or memory', 'leukocyte apoptotic process', 'luteolysis', 'negative regulation of activated T cell proliferation', 'negative regulation of apoptotic process', 'negative regulation of B cell proliferation', 'neuron apoptotic process', 'neuron differentiation', 'neurotrophin TRK receptor signaling pathway', 'platelet formation', 'positive regulation of amyloid-beta formation', 'positive regulation of apoptotic DNA fragmentation', 'positive regulation of apoptotic process', 'positive regulation of neuron apoptotic process', 'protein catabolic process', 'protein processing', 'proteolysis', 'regulation of macroautophagy', 'regulation of protein stability', 'response to amino acid', 'response to antibiotic', 'response to cobalt ion', 'response to estradiol', 'response to glucocorticoid', 'response to glucose', 'response to hydrogen peroxide', 'response to hypoxia', 'response to lipopolysaccharide', 'response to nicotine', 'response to tumor necrosis factor', 'response to UV', 'response to X-ray', 'response to xenobiotic stimulus', 'sensory perception of sound', 'striated muscle cell differentiation', 'T cell homeostasis', 'wound healing']
Endothelin-1
53
Endothelin-1
67
4.0
58
0.44
P05305P05305['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'artery smooth muscle contraction', 'axon extension', 'axonogenesis involved in innervation', 'body fluid secretion', 'branching involved in blood vessel morphogenesis', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cardiac neural crest cell migration involved in outflow tract morphogenesis', 'cartilage development', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to calcium ion', 'cellular response to fatty acid', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to human chorionic gonadotropin stimulus', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to luteinizing hormone stimulus', 'cellular response to mineralocorticoid stimulus', 'cellular response to organic substance', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to xenobiotic stimulus', 'dorsal/ventral pattern formation', 'embryonic heart tube development', 'endothelin receptor signaling pathway', 'endothelin receptor signaling pathway involved in heart process', 'epithelial fluid transport', 'ERK1 and ERK2 cascade', 'G protein-coupled receptor signaling pathway', 'histamine secretion', 'I-kappaB kinase/NF-kappaB signaling', 'in utero embryonic development', 'inositol phosphate-mediated signaling', 'leukocyte activation', 'maternal process involved in parturition', 'meiotic cell cycle process involved in oocyte maturation', 'membrane depolarization', 'middle ear morphogenesis', 'mitochondrion organization', 'multicellular organism aging', 'negative regulation of blood coagulation', 'negative regulation of gene expression', 'negative regulation of hormone secretion', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein metabolic process', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'neural crest cell fate commitment', 'nitric oxide transport', 'noradrenergic neuron differentiation', 'peptide hormone secretion', 'pharyngeal arch artery morphogenesis', 'phosphatidylinositol 3-kinase signaling', 'phospholipase D-activating G protein-coupled receptor signaling pathway', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cation channel activity', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell size', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell migration', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of JUN kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of odontogenesis', 'positive regulation of prostaglandin secretion', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'positive regulation of renal sodium excretion', 'positive regulation of sarcomere organization', 'positive regulation of signaling receptor activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'prostaglandin biosynthetic process', 'protein kinase A signaling', 'protein kinase C deactivation', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'regulation of glucose transmembrane transport', 'regulation of pH', 'regulation of sensory perception of pain', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'renal sodium ion absorption', 'respiratory gaseous exchange by respiratory system', 'response to activity', 'response to amino acid', 'response to amphetamine', 'response to dexamethasone', 'response to leptin', 'response to lipopolysaccharide', 'response to muscle stretch', 'response to nicotine', 'response to ozone', 'response to prostaglandin F', 'response to salt', 'response to testosterone', 'rhythmic excitation', 'semaphorin-plexin signaling pathway involved in axon guidance', 'sensory perception of pain', 'superoxide anion generation', 'sympathetic neuron axon guidance', 'thyroid gland development', 'transcription by RNA polymerase II', 'vasoconstriction', 'vein smooth muscle contraction']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'artery smooth muscle contraction', 'axon extension', 'axonogenesis involved in innervation', 'body fluid secretion', 'branching involved in blood vessel morphogenesis', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cardiac neural crest cell migration involved in outflow tract morphogenesis', 'cartilage development', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to calcium ion', 'cellular response to fatty acid', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to human chorionic gonadotropin stimulus', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to luteinizing hormone stimulus', 'cellular response to mineralocorticoid stimulus', 'cellular response to organic substance', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to xenobiotic stimulus', 'dorsal/ventral pattern formation', 'embryonic heart tube development', 'endothelin receptor signaling pathway', 'endothelin receptor signaling pathway involved in heart process', 'epithelial fluid transport', 'ERK1 and ERK2 cascade', 'G protein-coupled receptor signaling pathway', 'histamine secretion', 'I-kappaB kinase/NF-kappaB signaling', 'in utero embryonic development', 'inositol phosphate-mediated signaling', 'leukocyte activation', 'maternal process involved in parturition', 'meiotic cell cycle process involved in oocyte maturation', 'membrane depolarization', 'middle ear morphogenesis', 'mitochondrion organization', 'multicellular organism aging', 'negative regulation of blood coagulation', 'negative regulation of gene expression', 'negative regulation of hormone secretion', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein metabolic process', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'neural crest cell fate commitment', 'nitric oxide transport', 'noradrenergic neuron differentiation', 'peptide hormone secretion', 'pharyngeal arch artery morphogenesis', 'phosphatidylinositol 3-kinase signaling', 'phospholipase D-activating G protein-coupled receptor signaling pathway', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cation channel activity', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell size', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell migration', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of JUN kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of odontogenesis', 'positive regulation of prostaglandin secretion', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'positive regulation of renal sodium excretion', 'positive regulation of sarcomere organization', 'positive regulation of signaling receptor activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'prostaglandin biosynthetic process', 'protein kinase A signaling', 'protein kinase C deactivation', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'regulation of glucose transmembrane transport', 'regulation of pH', 'regulation of sensory perception of pain', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'renal sodium ion absorption', 'respiratory gaseous exchange by respiratory system', 'response to activity', 'response to amino acid', 'response to amphetamine', 'response to dexamethasone', 'response to leptin', 'response to lipopolysaccharide', 'response to muscle stretch', 'response to nicotine', 'response to ozone', 'response to prostaglandin F', 'response to salt', 'response to testosterone', 'rhythmic excitation', 'semaphorin-plexin signaling pathway involved in axon guidance', 'sensory perception of pain', 'superoxide anion generation', 'sympathetic neuron axon guidance', 'thyroid gland development', 'transcription by RNA polymerase II', 'vasoconstriction', 'vein smooth muscle contraction']
Insulin-degrading enzyme
414
Islet amyloid polypeptide
35
8.3
63
0.19
Q5T5N2P10997['amyloid-beta clearance', 'amyloid-beta clearance by cellular catabolic process', 'amyloid-beta metabolic process', 'antigen processing and presentation of endogenous peptide antigen via MHC class I', 'bradykinin catabolic process', 'determination of adult lifespan', 'hormone catabolic process', 'insulin catabolic process', 'insulin metabolic process', 'insulin receptor signaling pathway', 'peptide catabolic process', 'positive regulation of protein binding', 'positive regulation of protein catabolic process', 'protein catabolic process', 'proteolysis', 'proteolysis involved in protein catabolic process', 'regulation of aerobic respiration', 'ubiquitin recycling']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'amylin receptor signaling pathway', 'amyloid fibril formation', 'apoptotic process', 'bone resorption', 'cell-cell signaling', 'eating behavior', 'negative regulation of amyloid fibril formation', 'negative regulation of bone resorption', 'negative regulation of cell population proliferation', 'negative regulation of mitochondrion organization', 'negative regulation of osteoclast differentiation', 'negative regulation of protein-containing complex assembly', 'osteoclast differentiation', 'positive regulation of apoptotic process', 'positive regulation of calcium ion import across plasma membrane', 'positive regulation of cell death', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'protein destabilization', 'protein homooligomerization', 'sensory perception of pain', 'signal transduction']
Trypsin-3
277
Tissue factor pathway inhibitor
171
9.9
85
0.12
P35030P10646['antimicrobial humoral response', 'digestion', 'endothelial cell migration', 'proteolysis', 'zymogen activation']['blood coagulation', 'cellular response to steroid hormone stimulus', 'negative regulation of blood coagulation']
Hepatocyte growth factor-like protein
468
Hepatocyte growth factor-like protein
588
2.1
nan
nan
P26927P26927['histone H2A-S139 phosphorylation', 'negative regulation of gluconeogenesis', 'proteolysis', 'regulation of cAMP-dependent protein kinase activity', 'regulation of receptor signaling pathway via JAK-STAT']['histone H2A-S139 phosphorylation', 'negative regulation of gluconeogenesis', 'proteolysis', 'regulation of cAMP-dependent protein kinase activity', 'regulation of receptor signaling pathway via JAK-STAT']
Formylglycine-generating enzyme
341
Arylsulfatase A
69
2.1
nan
nan
Q8NBK3P15289['glycosphingolipid metabolic process', 'post-translational protein modification', 'protein oxidation']['lipid metabolic process']
Amyloid beta precursor like protein 2
310
Amyloid beta precursor like protein 2
360
2.1
nan
nan
Q06481Q06481['axonogenesis', 'central nervous system development', 'G protein-coupled receptor signaling pathway', 'regulation of cellular protein metabolic process']['axonogenesis', 'central nervous system development', 'G protein-coupled receptor signaling pathway', 'regulation of cellular protein metabolic process']
Ribonuclease pancreatic
32
Ribonuclease pancreatic
123
9.6
59
0.18
P07998P07998['defense response to Gram-positive bacterium', 'RNA phosphodiester bond hydrolysis']['defense response to Gram-positive bacterium', 'RNA phosphodiester bond hydrolysis']
Integrin alpha-X
920
Integrin beta-2
670
9.9
61
0.16
P20702P05107['animal organ morphogenesis', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell-cell adhesion', 'cell-matrix adhesion', 'defense response to virus', 'heterotypic cell-cell adhesion', 'integrin-mediated signaling pathway', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of endothelial tube morphogenesis', 'positive regulation of gene expression', 'positive regulation of myelination']['amyloid-beta clearance', 'apoptotic process', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-cell adhesion', 'cell-cell adhesion via plasma-membrane adhesion molecules', 'cell-cell signaling', 'cell-matrix adhesion', 'cellular response to low-density lipoprotein particle stimulus', 'endodermal cell differentiation', 'heterotypic cell-cell adhesion', 'inflammatory response', 'integrin-mediated signaling pathway', 'leukocyte cell-cell adhesion', 'microglial cell activation', 'negative regulation of dopamine metabolic process', 'neutrophil chemotaxis', 'neutrophil migration', 'phagocytosis, engulfment', 'positive regulation of leukocyte adhesion to vascular endothelial cell', 'positive regulation of neuron death', 'positive regulation of neutrophil degranulation', 'positive regulation of prostaglandin-E synthase activity', 'positive regulation of protein targeting to membrane', 'positive regulation of superoxide anion generation', 'receptor clustering', 'receptor internalization', 'receptor-mediated endocytosis', 'regulation of cell shape', 'regulation of peptidyl-tyrosine phosphorylation']
RB1-inducible coiled-coil protein 1
1565
RB1-inducible coiled-coil protein 1
925
8.5
53
0.22
Q8TDY2Q8TDY2['autophagosome assembly', 'autophagy', 'autophagy of mitochondrion', 'autophagy of peroxisome', 'cell cycle', 'extrinsic apoptotic signaling pathway', 'glycophagy', 'heart development', 'liver development', 'negative regulation of cell population proliferation', 'negative regulation of extrinsic apoptotic signaling pathway', 'piecemeal microautophagy of the nucleus', 'positive regulation of autophagy', 'positive regulation of cell size', 'positive regulation of JNK cascade', 'positive regulation of protein phosphorylation', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of protein lipidation', 'reticulophagy']['autophagosome assembly', 'autophagy', 'autophagy of mitochondrion', 'autophagy of peroxisome', 'cell cycle', 'extrinsic apoptotic signaling pathway', 'glycophagy', 'heart development', 'liver development', 'negative regulation of cell population proliferation', 'negative regulation of extrinsic apoptotic signaling pathway', 'piecemeal microautophagy of the nucleus', 'positive regulation of autophagy', 'positive regulation of cell size', 'positive regulation of JNK cascade', 'positive regulation of protein phosphorylation', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of protein lipidation', 'reticulophagy']
Kinesin-like protein KIF21A
1421
Kinesin-like protein KIF21A
1006
8.0
75
0.17
Q7Z4S6Q7Z4S6['microtubule-based movement']['microtubule-based movement']
Suppressor of tumorigenicity 14 protein
731
Suppressor of tumorigenicity 14 protein
604
2.0
nan
nan
Q9Y5Y6Q9Y5Y6['epithelial cell morphogenesis involved in placental branching', 'keratinocyte differentiation', 'neural tube closure', 'protein catabolic process', 'proteolysis']['epithelial cell morphogenesis involved in placental branching', 'keratinocyte differentiation', 'neural tube closure', 'protein catabolic process', 'proteolysis']
NF-kappa-B essential modulator
76
Inhibitor of nuclear factor kappa-B kinase subunit alpha
114
8.8
66
0.17
Q9Y6K9O15111['anoikis', 'apoptotic process', 'cellular response to DNA damage stimulus', 'establishment of vesicle localization', 'I-kappaB kinase/NF-kappaB signaling', 'immune response', 'inflammatory response', 'innate immune response', 'negative regulation of neuron death', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of macroautophagy', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of T cell receptor signaling pathway', 'positive regulation of transcription by RNA polymerase II', 'protein-containing complex assembly', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'response to virus', 'T cell receptor signaling pathway']['anatomical structure morphogenesis', 'cellular response to cadmium ion', 'cellular response to reactive oxygen species', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'I-kappaB kinase/NF-kappaB signaling', 'I-kappaB phosphorylation', 'immune response', 'inflammatory response', 'innate immune response', 'negative regulation of NF-kappaB transcription factor activity', 'NIK/NF-kappaB signaling', 'peptidyl-serine phosphorylation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interferon-alpha production', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein phosphorylation', 'response to virus', 'tumor necrosis factor-mediated signaling pathway']
Transcription regulator protein BACH2
125
Transcription regulator protein BACH2
125
2.0
53
0.93
Q9BYV9Q9BYV9['import into nucleus', 'negative regulation of transcription by RNA polymerase II', 'primary adaptive immune response involving T cells and B cells', 'regulation of transcription by RNA polymerase II']['import into nucleus', 'negative regulation of transcription by RNA polymerase II', 'primary adaptive immune response involving T cells and B cells', 'regulation of transcription by RNA polymerase II']
Integrin alpha-IIb
959
Integrin beta-3
689
9.4
nan
nan
Q17R67P05106['angiogenesis', 'cell adhesion mediated by integrin', 'cell-cell adhesion', 'cell-matrix adhesion', 'integrin-mediated signaling pathway']['activation of protein kinase activity', 'angiogenesis involved in wound healing', 'apolipoprotein A-I-mediated signaling pathway', 'apoptotic cell clearance', 'blood coagulation', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-matrix adhesion', 'cell-substrate adhesion', 'cell-substrate junction assembly', 'cellular response to insulin-like growth factor stimulus', 'cellular response to mechanical stimulus', 'cellular response to platelet-derived growth factor stimulus', 'cellular response to xenobiotic stimulus', 'embryo implantation', 'heterotypic cell-cell adhesion', 'integrin-mediated signaling pathway', 'mesodermal cell differentiation', 'negative chemotaxis', 'negative regulation of cell death', 'negative regulation of lipid storage', 'negative regulation of lipid transport', 'negative regulation of lipoprotein metabolic process', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of macrophage derived foam cell differentiation', 'platelet activation', 'platelet aggregation', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway', 'positive regulation of angiogenesis', 'positive regulation of bone resorption', 'positive regulation of cell adhesion mediated by integrin', 'positive regulation of cell-matrix adhesion', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of osteoblast proliferation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein phosphorylation', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of T cell migration', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of actin cytoskeleton organization', 'regulation of bone resorption', 'regulation of extracellular matrix organization', 'regulation of postsynaptic neurotransmitter receptor internalization', 'regulation of protein localization', 'regulation of protein tyrosine kinase activity', 'regulation of release of sequestered calcium ion into cytosol', 'regulation of serotonin uptake', 'regulation of trophoblast cell migration', 'response to activity', 'response to radiation', 'smooth muscle cell migration', 'substrate adhesion-dependent cell spreading', 'tube development', 'viral entry into host cell', 'wound healing']
Hepcidin
81
Neutrophil gelatinase-associated lipocalin
76
5.5
72
0.25
P81172P80188['acute-phase response', 'aging', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular iron ion homeostasis', 'cellular response to bile acid', 'cellular response to interleukin-6', 'cellular response to lipopolysaccharide', 'cellular response to tumor necrosis factor', 'cellular response to X-ray', 'defense response to bacterium', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'establishment of localization in cell', 'immune response', 'iron ion transmembrane transport', 'killing of cells of another organism', 'liver regeneration', 'macrophage activation', 'multicellular organismal iron ion homeostasis', 'myeloid cell homeostasis', 'negative regulation of bone resorption', 'negative regulation of inflammatory response', 'negative regulation of intestinal absorption', 'negative regulation of ion transmembrane transporter activity', 'negative regulation of iron export across plasma membrane', 'negative regulation of iron ion transmembrane transport', 'negative regulation of iron ion transmembrane transporter activity', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of macrophage activation', 'positive regulation of protein catabolic process', 'positive regulation of protein polyubiquitination', 'positive regulation of receptor catabolic process', 'positive regulation of receptor internalization', 'positive regulation of transcription by RNA polymerase II', 'protein catabolic process', 'receptor signaling pathway via JAK-STAT', 'response to erythropoietin', 'response to ethanol', 'response to iron ion', 'response to iron ion starvation', 'response to vitamin A', 'response to zinc ion', 'transcription by RNA polymerase II']['apoptotic process', 'defense response to bacterium', 'innate immune response', 'positive regulation of cold-induced thermogenesis', 'sequestering of iron ion', 'siderophore transport']
Tubulinyl-Tyr carboxypeptidase 2
158
Tubulin alpha-1B chain
450
2.1
79
0.61
Q86V25P68363['axon development', 'cell-cell fusion', 'labyrinthine layer blood vessel development', 'positive regulation of angiogenesis', 'positive regulation of endothelial cell proliferation', 'proteolysis', 'regulation of angiogenesis', 'syncytium formation by plasma membrane fusion']['cell division', 'cellular response to interleukin-4', 'cytoskeleton-dependent intracellular transport', 'microtubule cytoskeleton organization', 'microtubule-based process', 'mitotic cell cycle']
Adhesion G protein-coupled receptor B1
461
Adhesion G protein-coupled receptor B1
446
9.8
32
0.32
Q3UHD1Q3UHD1['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'apoptotic cell clearance', 'cell surface receptor signaling pathway', 'defense response to Gram-negative bacterium', 'engulfment of apoptotic cell', 'innate immune response', 'muscle organ development', 'negative regulation of angiogenesis', 'negative regulation of endothelial cell migration', 'negative regulation of protein catabolic process', 'negative regulation of protein ubiquitination', 'nervous system development', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of myoblast fusion', 'positive regulation of reactive oxygen species biosynthetic process', 'positive regulation of synapse assembly', 'postsynaptic actin cytoskeleton organization', 'regulation of synapse assembly', 'regulation of synaptic plasticity']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'apoptotic cell clearance', 'cell surface receptor signaling pathway', 'defense response to Gram-negative bacterium', 'engulfment of apoptotic cell', 'innate immune response', 'muscle organ development', 'negative regulation of angiogenesis', 'negative regulation of endothelial cell migration', 'negative regulation of protein catabolic process', 'negative regulation of protein ubiquitination', 'nervous system development', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of myoblast fusion', 'positive regulation of reactive oxygen species biosynthetic process', 'positive regulation of synapse assembly', 'postsynaptic actin cytoskeleton organization', 'regulation of synapse assembly', 'regulation of synaptic plasticity']
Spindle assembly abnormal protein 6 homolog
310
Spindle assembly abnormal protein 6 homolog
310
5.8
30
0.58
Q6UVJ0Q6UVJ0['centriole replication', 'centrosome duplication', 'positive regulation of centriole replication', 'positive regulation of G1/S transition of mitotic cell cycle', 'positive regulation of spindle assembly', 'regulation of mitotic spindle organization']['centriole replication', 'centrosome duplication', 'positive regulation of centriole replication', 'positive regulation of G1/S transition of mitotic cell cycle', 'positive regulation of spindle assembly', 'regulation of mitotic spindle organization']
C-C motif chemokine 5
33
C-C motif chemokine 5
33
4.0
76
0.33
P13501P13501['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'chemokine-mediated signaling pathway', 'chemotaxis', 'dendritic cell chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of innate immune response', 'positive regulation of macrophage chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of translational initiation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of viral genome replication', 'protein kinase B signaling', 'regulation of chronic inflammatory response', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to toxic substance', 'response to virus']['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'chemokine-mediated signaling pathway', 'chemotaxis', 'dendritic cell chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of innate immune response', 'positive regulation of macrophage chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of translational initiation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of viral genome replication', 'protein kinase B signaling', 'regulation of chronic inflammatory response', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to toxic substance', 'response to virus']
Haptoglobin
33
Haptoglobin
33
2.0
nan
nan
P00738P00738['acute inflammatory response', 'acute-phase response', 'defense response', 'defense response to bacterium', 'immune system process', 'negative regulation of hydrogen peroxide catabolic process', 'negative regulation of oxidoreductase activity', 'positive regulation of cell death', 'response to hydrogen peroxide', 'zymogen activation']['acute inflammatory response', 'acute-phase response', 'defense response', 'defense response to bacterium', 'immune system process', 'negative regulation of hydrogen peroxide catabolic process', 'negative regulation of oxidoreductase activity', 'positive regulation of cell death', 'response to hydrogen peroxide', 'zymogen activation']
cGMP-specific 3',5'-cyclic phosphodiesterase
677
cGMP-specific 3',5'-cyclic phosphodiesterase
677
4.0
56
0.44
O76074O76074['cGMP catabolic process', 'negative regulation of cardiac muscle contraction', 'negative regulation of T cell proliferation', 'oocyte development', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of MAP kinase activity', 'positive regulation of oocyte development', 'regulation of nitric oxide mediated signal transduction', 'relaxation of cardiac muscle', 'signal transduction', 'T cell proliferation']['cGMP catabolic process', 'negative regulation of cardiac muscle contraction', 'negative regulation of T cell proliferation', 'oocyte development', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of MAP kinase activity', 'positive regulation of oocyte development', 'regulation of nitric oxide mediated signal transduction', 'relaxation of cardiac muscle', 'signal transduction', 'T cell proliferation']
PRSS3 protein
224
Amyloid-beta A4 protein
34
9.7
83
0.12
Q8N2U3H7C0V9['proteolysis']['nervous system development']
Interleukin-18
104
Interleukin-18
104
2.0
61
0.81
Q14116Q14116['activation of protein kinase B activity', 'angiogenesis', 'cell population proliferation', 'cell-cell signaling', 'cellular response to organic cyclic compound', 'cholesterol homeostasis', 'defense response to Gram-positive bacterium', 'establishment of skin barrier', 'inflammatory response', 'interleukin-18-mediated signaling pathway', 'lipopolysaccharide-mediated signaling pathway', 'MAPK cascade', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of myoblast differentiation', 'neutrophil activation', 'NIK/NF-kappaB signaling', 'positive regulation of activated T cell proliferation', 'positive regulation of chemokine production', 'positive regulation of cold-induced thermogenesis', 'positive regulation of granulocyte macrophage colony-stimulating factor production', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-13 production', 'positive regulation of interleukin-17 production', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of natural killer cell proliferation', 'positive regulation of neuroinflammatory response', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of NK T cell proliferation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T-helper 1 cell cytokine production', 'positive regulation of T-helper 2 cell differentiation', 'positive regulation of tissue remodeling', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tyrosine phosphorylation of STAT protein', 'regulation of cell adhesion', 'sleep', 'T-helper 1 type immune response', 'triglyceride homeostasis', 'type 2 immune response']['activation of protein kinase B activity', 'angiogenesis', 'cell population proliferation', 'cell-cell signaling', 'cellular response to organic cyclic compound', 'cholesterol homeostasis', 'defense response to Gram-positive bacterium', 'establishment of skin barrier', 'inflammatory response', 'interleukin-18-mediated signaling pathway', 'lipopolysaccharide-mediated signaling pathway', 'MAPK cascade', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of myoblast differentiation', 'neutrophil activation', 'NIK/NF-kappaB signaling', 'positive regulation of activated T cell proliferation', 'positive regulation of chemokine production', 'positive regulation of cold-induced thermogenesis', 'positive regulation of granulocyte macrophage colony-stimulating factor production', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-13 production', 'positive regulation of interleukin-17 production', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of natural killer cell proliferation', 'positive regulation of neuroinflammatory response', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of NK T cell proliferation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T-helper 1 cell cytokine production', 'positive regulation of T-helper 2 cell differentiation', 'positive regulation of tissue remodeling', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tyrosine phosphorylation of STAT protein', 'regulation of cell adhesion', 'sleep', 'T-helper 1 type immune response', 'triglyceride homeostasis', 'type 2 immune response']
Hepcidin
69
Neutrophil gelatinase-associated lipocalin
76
10.0
81
0.12
P81172P80188['acute-phase response', 'aging', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular iron ion homeostasis', 'cellular response to bile acid', 'cellular response to interleukin-6', 'cellular response to lipopolysaccharide', 'cellular response to tumor necrosis factor', 'cellular response to X-ray', 'defense response to bacterium', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'establishment of localization in cell', 'immune response', 'iron ion transmembrane transport', 'killing of cells of another organism', 'liver regeneration', 'macrophage activation', 'multicellular organismal iron ion homeostasis', 'myeloid cell homeostasis', 'negative regulation of bone resorption', 'negative regulation of inflammatory response', 'negative regulation of intestinal absorption', 'negative regulation of ion transmembrane transporter activity', 'negative regulation of iron export across plasma membrane', 'negative regulation of iron ion transmembrane transport', 'negative regulation of iron ion transmembrane transporter activity', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of macrophage activation', 'positive regulation of protein catabolic process', 'positive regulation of protein polyubiquitination', 'positive regulation of receptor catabolic process', 'positive regulation of receptor internalization', 'positive regulation of transcription by RNA polymerase II', 'protein catabolic process', 'receptor signaling pathway via JAK-STAT', 'response to erythropoietin', 'response to ethanol', 'response to iron ion', 'response to iron ion starvation', 'response to vitamin A', 'response to zinc ion', 'transcription by RNA polymerase II']['apoptotic process', 'defense response to bacterium', 'innate immune response', 'positive regulation of cold-induced thermogenesis', 'sequestering of iron ion', 'siderophore transport']
Haptoglobin
33
Haptoglobin
33
2.0
nan
nan
Q8SPS7Q8SPS7['acute inflammatory response', 'acute-phase response', 'defense response to bacterium', 'immune system process', 'positive regulation of cell death', 'zymogen activation']['acute inflammatory response', 'acute-phase response', 'defense response to bacterium', 'immune system process', 'positive regulation of cell death', 'zymogen activation']
PRSS3 protein
52
Amyloid-beta A4 protein
17
8.4
97
0.12
Q8N2U3H7C0V9['proteolysis']['nervous system development']
Macrophage migration inhibitory factor
99
Macrophage migration inhibitory factor
99
8.1
73
0.17
P14174P14174['carboxylic acid metabolic process', 'cell surface receptor signaling pathway', 'cellular senescence', 'DNA damage response, signal transduction by p53 class mediator', 'inflammatory response', 'innate immune response', 'negative regulation of apoptotic process', 'negative regulation of cell migration', 'negative regulation of cellular senescence', 'negative regulation of DNA damage response, signal transduction by p53 class mediator', 'negative regulation of gene expression', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'negative regulation of macrophage chemotaxis', 'negative regulation of mature B cell apoptotic process', 'negative regulation of myeloid cell apoptotic process', 'negative regulation of protein metabolic process', 'positive regulation of arachidonic acid secretion', 'positive regulation of B cell proliferation', 'positive regulation of cell population proliferation', 'positive regulation of chemokine (C-X-C motif) ligand 2 production', 'positive regulation of cytokine production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of lipopolysaccharide-mediated signaling pathway', 'positive regulation of MAP kinase activity', 'positive regulation of myeloid leukocyte cytokine production involved in immune response', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of prostaglandin secretion involved in immune response', 'positive regulation of protein kinase A signaling', 'positive regulation of tumor necrosis factor production', 'prostaglandin biosynthetic process', 'protein homotrimerization', 'regulation of macrophage activation']['carboxylic acid metabolic process', 'cell surface receptor signaling pathway', 'cellular senescence', 'DNA damage response, signal transduction by p53 class mediator', 'inflammatory response', 'innate immune response', 'negative regulation of apoptotic process', 'negative regulation of cell migration', 'negative regulation of cellular senescence', 'negative regulation of DNA damage response, signal transduction by p53 class mediator', 'negative regulation of gene expression', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'negative regulation of macrophage chemotaxis', 'negative regulation of mature B cell apoptotic process', 'negative regulation of myeloid cell apoptotic process', 'negative regulation of protein metabolic process', 'positive regulation of arachidonic acid secretion', 'positive regulation of B cell proliferation', 'positive regulation of cell population proliferation', 'positive regulation of chemokine (C-X-C motif) ligand 2 production', 'positive regulation of cytokine production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of lipopolysaccharide-mediated signaling pathway', 'positive regulation of MAP kinase activity', 'positive regulation of myeloid leukocyte cytokine production involved in immune response', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of prostaglandin secretion involved in immune response', 'positive regulation of protein kinase A signaling', 'positive regulation of tumor necrosis factor production', 'prostaglandin biosynthetic process', 'protein homotrimerization', 'regulation of macrophage activation']
Amyloid-beta precursor protein
8
Amyloid-beta precursor protein
18
8.8
50
0.23
P05067P05067['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Ribonuclease pancreatic
31
Ribonuclease pancreatic
32
2.1
64
0.76
P07998P07998['defense response to Gram-positive bacterium', 'RNA phosphodiester bond hydrolysis']['defense response to Gram-positive bacterium', 'RNA phosphodiester bond hydrolysis']
MHC class II HLA-DQ-alpha chain
72
MHC class II antigen
11
2.0
58
0.84
Q30069A0A6B9KAL0['adaptive immune response', 'antigen processing and presentation of peptide or polysaccharide antigen via MHC class II']['adaptive immune response', 'antigen processing and presentation of peptide or polysaccharide antigen via MHC class II']
MHC class II HLA-DQ-alpha chain
72
MHC class II HLA-DQ-beta-1
11
2.0
49
1.0
Q30069O19707['adaptive immune response', 'antigen processing and presentation of peptide or polysaccharide antigen via MHC class II']['adaptive immune response', 'antigen processing and presentation of peptide or polysaccharide antigen via MHC class II']
Amyloid-beta precursor protein
21
Amyloid-beta precursor protein
5
7.5
41
0.33
P05067P05067['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
H-2 class II histocompatibility antigen, A-D alpha chain
64
H2-Ab1 protein
-19
2.1
87
0.55
P04228Q31135['adaptive immune response', 'antigen processing and presentation', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'antigen processing and presentation of peptide antigen', 'negative regulation of T cell proliferation', 'peptide antigen assembly with MHC class II protein complex', 'positive regulation of T cell activation', 'positive regulation of T cell differentiation']['adaptive immune response', 'antigen processing and presentation of exogenous peptide antigen via MHC class II']
Ig-like domain-containing protein
166
Ig-like domain-containing protein
168
2.1
74
0.65
Q6PIR9Q7TND8[][]
Immunoglobulin lambda variable 2-8
215
Immunoglobulin lambda variable 2-8
215
2.0
34
1.44
P01709P01709['adaptive immune response', 'immune response']['adaptive immune response', 'immune response']
Glutamate receptor ionotropic, kainate 2
94
Glutamate receptor ionotropic, kainate 2
236
2.1
60
0.8
P42260P42260['behavioral fear response', 'cellular calcium ion homeostasis', 'chemical synaptic transmission', 'detection of cold stimulus involved in thermoception', 'excitatory postsynaptic potential', 'inhibitory postsynaptic potential', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of synaptic transmission, glutamatergic', 'neuron apoptotic process', 'neuronal action potential', 'positive regulation of neuron apoptotic process', 'positive regulation of synaptic transmission', 'presynaptic modulation of chemical synaptic transmission', 'receptor clustering', 'regulation of JNK cascade', 'regulation of long-term neuronal synaptic plasticity', 'regulation of membrane potential', 'regulation of short-term neuronal synaptic plasticity', 'synaptic transmission, glutamatergic']['behavioral fear response', 'cellular calcium ion homeostasis', 'chemical synaptic transmission', 'detection of cold stimulus involved in thermoception', 'excitatory postsynaptic potential', 'inhibitory postsynaptic potential', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of synaptic transmission, glutamatergic', 'neuron apoptotic process', 'neuronal action potential', 'positive regulation of neuron apoptotic process', 'positive regulation of synaptic transmission', 'presynaptic modulation of chemical synaptic transmission', 'receptor clustering', 'regulation of JNK cascade', 'regulation of long-term neuronal synaptic plasticity', 'regulation of membrane potential', 'regulation of short-term neuronal synaptic plasticity', 'synaptic transmission, glutamatergic']
Echinoderm microtubule-associated protein-like 2
50
Echinoderm microtubule-associated protein-like 2
50
6.7
59
0.25
O95834O95834['microtubule cytoskeleton organization', 'negative regulation of microtubule polymerization', 'regulation of microtubule nucleation', 'sensory perception of sound', 'visual perception']['microtubule cytoskeleton organization', 'negative regulation of microtubule polymerization', 'regulation of microtubule nucleation', 'sensory perception of sound', 'visual perception']
Cathelicidin antimicrobial peptide
24
Cathelicidin antimicrobial peptide
24
2.1
45
1.06
P49913P49913['antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'cellular response to lipopolysaccharide', 'cellular response to peptidoglycan', 'cellular response to tumor necrosis factor', 'chronic inflammatory response', 'cytolysis by host of symbiont cells', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'modulation of process of another organism', 'neutrophil activation', 'positive regulation of angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of interleukin-8 production', 'positive regulation of protein phosphorylation', 'response to yeast']['antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'cellular response to lipopolysaccharide', 'cellular response to peptidoglycan', 'cellular response to tumor necrosis factor', 'chronic inflammatory response', 'cytolysis by host of symbiont cells', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'modulation of process of another organism', 'neutrophil activation', 'positive regulation of angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of interleukin-8 production', 'positive regulation of protein phosphorylation', 'response to yeast']
Immunoglobulin heavy constant epsilon
335
Immunoglobulin heavy constant epsilon
335
2.0
40
1.23
P01854P01854['adaptive immune response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
Isoform A of Ketohexokinase
98
Isoform A of Ketohexokinase
98
3.8
91
0.29
P50053-2P50053-2[][]
Cytochrome c oxidase assembly factor 6 homolog
59
Cytochrome c oxidase assembly factor 6 homolog
59
2.0
67
0.73
Q5JTJ3Q5JTJ3['mitochondrial ATP synthesis coupled electron transport', 'plasma membrane ATP synthesis coupled electron transport', 'respiratory chain complex IV assembly']['mitochondrial ATP synthesis coupled electron transport', 'plasma membrane ATP synthesis coupled electron transport', 'respiratory chain complex IV assembly']
Retinol-binding protein 2
32
Retinol-binding protein 2
28
6.7
66
0.23
P50120P50120['epidermis development', 'fatty acid transport', 'vitamin A metabolic process']['epidermis development', 'fatty acid transport', 'vitamin A metabolic process']
Tryptase alpha/beta-1
99
Tryptase alpha/beta-1
99
2.0
62
0.8
Q15661Q15661['defense response', 'extracellular matrix disassembly', 'proteolysis']['defense response', 'extracellular matrix disassembly', 'proteolysis']
Isoform A of Ketohexokinase
99
Isoform A of Ketohexokinase
98
9.0
91
0.12
P50053-2P50053-2[][]
Heat shock cognate 71 kDa protein
171
Putative tyrosine-protein phosphatase auxilin
876
2.0
67
0.73
P19120Q27974['cellular response to unfolded protein', 'chaperone cofactor-dependent protein refolding', 'chaperone-mediated autophagy translocation complex disassembly', 'late endosomal microautophagy', 'mRNA processing', 'negative regulation of transcription, DNA-templated', 'protein refolding', 'protein targeting to lysosome involved in chaperone-mediated autophagy', 'RNA splicing', 'slow axonal transport', 'synaptic vesicle uncoating', 'vesicle-mediated transport']['clathrin coat disassembly', 'clathrin-dependent endocytosis', 'dephosphorylation', 'synaptic vesicle uncoating']
T-cell receptor alpha chain C region
166
T-cell receptor beta-2 chain C region
168
2.1
76
0.63
P01849P01851['protein homotetramerization', 'response to bacterium', 'T cell lineage commitment']['B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
Cystatin-C
47
Cystatin-C
47
7.9
87
0.14
P01034P01034['defense response', 'negative regulation of blood vessel remodeling', 'negative regulation of collagen catabolic process', 'negative regulation of cysteine-type endopeptidase activity', 'negative regulation of elastin catabolic process', 'negative regulation of extracellular matrix disassembly', 'negative regulation of peptidase activity', 'negative regulation of proteolysis', 'regulation of tissue remodeling', 'supramolecular fiber organization']['defense response', 'negative regulation of blood vessel remodeling', 'negative regulation of collagen catabolic process', 'negative regulation of cysteine-type endopeptidase activity', 'negative regulation of elastin catabolic process', 'negative regulation of extracellular matrix disassembly', 'negative regulation of peptidase activity', 'negative regulation of proteolysis', 'regulation of tissue remodeling', 'supramolecular fiber organization']
Cystatin-C
47
Cystatin-C
69
8.7
85
0.14
P01034P01034['defense response', 'negative regulation of blood vessel remodeling', 'negative regulation of collagen catabolic process', 'negative regulation of cysteine-type endopeptidase activity', 'negative regulation of elastin catabolic process', 'negative regulation of extracellular matrix disassembly', 'negative regulation of peptidase activity', 'negative regulation of proteolysis', 'regulation of tissue remodeling', 'supramolecular fiber organization']['defense response', 'negative regulation of blood vessel remodeling', 'negative regulation of collagen catabolic process', 'negative regulation of cysteine-type endopeptidase activity', 'negative regulation of elastin catabolic process', 'negative regulation of extracellular matrix disassembly', 'negative regulation of peptidase activity', 'negative regulation of proteolysis', 'regulation of tissue remodeling', 'supramolecular fiber organization']
Insulin
10
Insulin
4
1.9
48
1.07
P01308P01308['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']
Amyloid-beta precursor protein
8
Amyloid-beta precursor protein
8
9.9
58
0.17
P05067P05067['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Immunoglobulin heavy constant epsilon
329
Immunoglobulin heavy constant epsilon
329
2.0
nan
nan
P01854P01854['adaptive immune response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
Ribosomal oxygenase 2
209
60S ribosomal protein L27a
37
2.0
53
0.93
Q8IUF8P46776['histone H3-K36 demethylation', 'histone H3-K4 demethylation', 'ribosome biogenesis']['cytoplasmic translation', 'translation']
Amyloid-beta precursor protein
18
Amyloid-beta precursor protein
18
7.4
52
0.26
P05067P05067['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Myosin-7
130
Myosin-7
130
5.5
66
0.28
P12883P12883['adult heart development', 'ATP metabolic process', 'cardiac muscle contraction', 'cardiac muscle hypertrophy in response to stress', 'muscle contraction', 'muscle filament sliding', 'regulation of heart rate', 'regulation of slow-twitch skeletal muscle fiber contraction', 'regulation of the force of heart contraction', 'regulation of the force of skeletal muscle contraction', 'sarcomere organization', 'skeletal muscle contraction', 'striated muscle contraction', 'transition between fast and slow fiber', 'ventricular cardiac muscle tissue morphogenesis']['adult heart development', 'ATP metabolic process', 'cardiac muscle contraction', 'cardiac muscle hypertrophy in response to stress', 'muscle contraction', 'muscle filament sliding', 'regulation of heart rate', 'regulation of slow-twitch skeletal muscle fiber contraction', 'regulation of the force of heart contraction', 'regulation of the force of skeletal muscle contraction', 'sarcomere organization', 'skeletal muscle contraction', 'striated muscle contraction', 'transition between fast and slow fiber', 'ventricular cardiac muscle tissue morphogenesis']
Immunoglobulin heavy constant gamma 1
349
Immunoglobulin heavy constant gamma 1
349
2.0
76
0.65
P01857P01857['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
Beta-2-microglobulin
33
Beta-2-microglobulin
33
2.0
70
0.72
P61769P61769['amyloid fibril formation', 'antibacterial humoral response', 'antigen processing and presentation of endogenous peptide antigen via MHC class I', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to iron ion', 'cellular response to iron(III) ion', 'cellular response to lipopolysaccharide', 'cellular response to nicotine', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'iron ion homeostasis', 'iron ion transport', 'learning or memory', 'negative regulation of epithelial cell proliferation', 'negative regulation of forebrain neuron differentiation', 'negative regulation of neurogenesis', 'negative regulation of neuron projection development', 'negative regulation of receptor binding', 'peptide antigen assembly with MHC class II protein complex', 'positive regulation of cellular senescence', 'positive regulation of ferrous iron binding', 'positive regulation of protein binding', 'positive regulation of receptor binding', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of T cell activation', 'positive regulation of T cell cytokine production', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of transferrin receptor binding', 'protein homotetramerization', 'protein refolding', 'regulation of erythrocyte differentiation', 'regulation of iron ion transport', 'regulation of membrane depolarization', 'response to molecule of bacterial origin', 'retina homeostasis', 'sensory perception of smell', 'T cell differentiation in thymus', 'T cell mediated cytotoxicity']['amyloid fibril formation', 'antibacterial humoral response', 'antigen processing and presentation of endogenous peptide antigen via MHC class I', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to iron ion', 'cellular response to iron(III) ion', 'cellular response to lipopolysaccharide', 'cellular response to nicotine', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'iron ion homeostasis', 'iron ion transport', 'learning or memory', 'negative regulation of epithelial cell proliferation', 'negative regulation of forebrain neuron differentiation', 'negative regulation of neurogenesis', 'negative regulation of neuron projection development', 'negative regulation of receptor binding', 'peptide antigen assembly with MHC class II protein complex', 'positive regulation of cellular senescence', 'positive regulation of ferrous iron binding', 'positive regulation of protein binding', 'positive regulation of receptor binding', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of T cell activation', 'positive regulation of T cell cytokine production', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of transferrin receptor binding', 'protein homotetramerization', 'protein refolding', 'regulation of erythrocyte differentiation', 'regulation of iron ion transport', 'regulation of membrane depolarization', 'response to molecule of bacterial origin', 'retina homeostasis', 'sensory perception of smell', 'T cell differentiation in thymus', 'T cell mediated cytotoxicity']
Retinol-binding protein 2
28
Retinol-binding protein 2
28
2.0
44
1.12
P50120P50120['epidermis development', 'fatty acid transport', 'vitamin A metabolic process']['epidermis development', 'fatty acid transport', 'vitamin A metabolic process']
Glutamate receptor 2
212
Glutamate receptor 2
212
2.0
53
0.93
P19491P19491['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']
Store-operated calcium entry-associated regulatory factor
320
Store-operated calcium entry-associated regulatory factor
98
2.0
54
0.91
Q96BY9Q96BY9['calcium ion transport', 'regulation of store-operated calcium entry']['calcium ion transport', 'regulation of store-operated calcium entry']
Nitric oxide synthase, brain
96
Nitric oxide synthase, brain
96
3.9
64
0.4
P29476P29476['aging', 'arginine catabolic process', 'behavioral response to cocaine', 'brain development', 'cellular response to epinephrine stimulus', 'cellular response to growth factor stimulus', 'cellular response to mechanical stimulus', 'establishment of protein localization', 'female pregnancy', 'multicellular organismal response to stress', 'muscle contraction', 'negative regulation of apoptotic process', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of cell population proliferation', 'negative regulation of cytosolic calcium ion concentration', 'negative regulation of heart contraction', 'negative regulation of hepatic stellate cell contraction', 'negative regulation of hydrolase activity', 'negative regulation of insulin secretion', 'negative regulation of iron ion transmembrane transport', 'negative regulation of neuron apoptotic process', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of potassium ion transport', 'negative regulation of serotonin uptake', 'negative regulation of vasoconstriction', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'positive regulation of guanylate cyclase activity', 'positive regulation of histone acetylation', 'positive regulation of long-term synaptic potentiation', 'positive regulation of neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of sodium ion transmembrane transport', 'positive regulation of the force of heart contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of heart contraction', 'regulation of neurogenesis', 'regulation of sensory perception of pain', 'regulation of sodium ion transport', 'response to activity', 'response to estrogen', 'response to ethanol', 'response to heat', 'response to hormone', 'response to hypoxia', 'response to lead ion', 'response to lipopolysaccharide', 'response to nicotine', 'response to nitric oxide', 'response to nutrient levels', 'response to organic cyclic compound', 'response to organonitrogen compound', 'response to peptide hormone', 'response to vitamin E', 'retrograde trans-synaptic signaling by nitric oxide', 'striated muscle contraction', 'synaptic signaling by nitric oxide', 'vasodilation', 'xenobiotic catabolic process']['aging', 'arginine catabolic process', 'behavioral response to cocaine', 'brain development', 'cellular response to epinephrine stimulus', 'cellular response to growth factor stimulus', 'cellular response to mechanical stimulus', 'establishment of protein localization', 'female pregnancy', 'multicellular organismal response to stress', 'muscle contraction', 'negative regulation of apoptotic process', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of cell population proliferation', 'negative regulation of cytosolic calcium ion concentration', 'negative regulation of heart contraction', 'negative regulation of hepatic stellate cell contraction', 'negative regulation of hydrolase activity', 'negative regulation of insulin secretion', 'negative regulation of iron ion transmembrane transport', 'negative regulation of neuron apoptotic process', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of potassium ion transport', 'negative regulation of serotonin uptake', 'negative regulation of vasoconstriction', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'positive regulation of guanylate cyclase activity', 'positive regulation of histone acetylation', 'positive regulation of long-term synaptic potentiation', 'positive regulation of neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of sodium ion transmembrane transport', 'positive regulation of the force of heart contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of heart contraction', 'regulation of neurogenesis', 'regulation of sensory perception of pain', 'regulation of sodium ion transport', 'response to activity', 'response to estrogen', 'response to ethanol', 'response to heat', 'response to hormone', 'response to hypoxia', 'response to lead ion', 'response to lipopolysaccharide', 'response to nicotine', 'response to nitric oxide', 'response to nutrient levels', 'response to organic cyclic compound', 'response to organonitrogen compound', 'response to peptide hormone', 'response to vitamin E', 'retrograde trans-synaptic signaling by nitric oxide', 'striated muscle contraction', 'synaptic signaling by nitric oxide', 'vasodilation', 'xenobiotic catabolic process']
Cytosolic acyl coenzyme A thioester hydrolase
61
Cytosolic acyl coenzyme A thioester hydrolase
61
3.9
76
0.34
Q91V12Q91V12['acyl-CoA metabolic process', 'coenzyme A biosynthetic process', 'fatty acid catabolic process', 'fatty acid metabolic process', 'long-chain fatty-acyl-CoA catabolic process', 'medium-chain fatty acid biosynthetic process', 'medium-chain fatty-acyl-CoA catabolic process', 'palmitic acid biosynthetic process']['acyl-CoA metabolic process', 'coenzyme A biosynthetic process', 'fatty acid catabolic process', 'fatty acid metabolic process', 'long-chain fatty-acyl-CoA catabolic process', 'medium-chain fatty acid biosynthetic process', 'medium-chain fatty-acyl-CoA catabolic process', 'palmitic acid biosynthetic process']
Ras GTPase-activating-like protein IQGAP1
161
Ras GTPase-activating-like protein IQGAP1
161
2.0
59
0.84
P46940P46940['cell migration', 'cellular response to calcium ion', 'cellular response to epidermal growth factor stimulus', 'cellular response to platelet-derived growth factor stimulus', 'epidermal growth factor receptor signaling pathway', 'fibroblast growth factor receptor signaling pathway', 'fibroblast migration', 'negative regulation of dephosphorylation', 'neuron projection extension', 'platelet-derived growth factor receptor signaling pathway', 'podocyte development', 'positive regulation of MAPK cascade', 'positive regulation of protein kinase activity', 'regulation of actin cytoskeleton organization', 'regulation of cytokine production', 'regulation of GTPase activity', 'regulation of mitotic cell cycle', 'signal transduction']['cell migration', 'cellular response to calcium ion', 'cellular response to epidermal growth factor stimulus', 'cellular response to platelet-derived growth factor stimulus', 'epidermal growth factor receptor signaling pathway', 'fibroblast growth factor receptor signaling pathway', 'fibroblast migration', 'negative regulation of dephosphorylation', 'neuron projection extension', 'platelet-derived growth factor receptor signaling pathway', 'podocyte development', 'positive regulation of MAPK cascade', 'positive regulation of protein kinase activity', 'regulation of actin cytoskeleton organization', 'regulation of cytokine production', 'regulation of GTPase activity', 'regulation of mitotic cell cycle', 'signal transduction']
Nucleotide exchange factor SIL1
357
Nucleotide exchange factor SIL1
357
7.8
72
0.18
Q9H173Q9H173['cotranslational protein targeting to membrane', 'intracellular protein transport', 'protein folding']['cotranslational protein targeting to membrane', 'intracellular protein transport', 'protein folding']
Myosin-7
130
Myosin-7
128
10.0
59
0.17
P12883P12883['adult heart development', 'ATP metabolic process', 'cardiac muscle contraction', 'cardiac muscle hypertrophy in response to stress', 'muscle contraction', 'muscle filament sliding', 'regulation of heart rate', 'regulation of slow-twitch skeletal muscle fiber contraction', 'regulation of the force of heart contraction', 'regulation of the force of skeletal muscle contraction', 'sarcomere organization', 'skeletal muscle contraction', 'striated muscle contraction', 'transition between fast and slow fiber', 'ventricular cardiac muscle tissue morphogenesis']['adult heart development', 'ATP metabolic process', 'cardiac muscle contraction', 'cardiac muscle hypertrophy in response to stress', 'muscle contraction', 'muscle filament sliding', 'regulation of heart rate', 'regulation of slow-twitch skeletal muscle fiber contraction', 'regulation of the force of heart contraction', 'regulation of the force of skeletal muscle contraction', 'sarcomere organization', 'skeletal muscle contraction', 'striated muscle contraction', 'transition between fast and slow fiber', 'ventricular cardiac muscle tissue morphogenesis']
Amyloid-beta precursor protein
3
Amyloid-beta precursor protein
7
2.0
nan
nan
P05067P05067['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Integrin alpha-X
920
Integrin beta-2
674
2.0
59
0.83
P20702P05107['animal organ morphogenesis', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell-cell adhesion', 'cell-matrix adhesion', 'defense response to virus', 'heterotypic cell-cell adhesion', 'integrin-mediated signaling pathway', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of endothelial tube morphogenesis', 'positive regulation of gene expression', 'positive regulation of myelination']['amyloid-beta clearance', 'apoptotic process', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-cell adhesion', 'cell-cell adhesion via plasma-membrane adhesion molecules', 'cell-cell signaling', 'cell-matrix adhesion', 'cellular response to low-density lipoprotein particle stimulus', 'endodermal cell differentiation', 'heterotypic cell-cell adhesion', 'inflammatory response', 'integrin-mediated signaling pathway', 'leukocyte cell-cell adhesion', 'microglial cell activation', 'negative regulation of dopamine metabolic process', 'neutrophil chemotaxis', 'neutrophil migration', 'phagocytosis, engulfment', 'positive regulation of leukocyte adhesion to vascular endothelial cell', 'positive regulation of neuron death', 'positive regulation of neutrophil degranulation', 'positive regulation of prostaglandin-E synthase activity', 'positive regulation of protein targeting to membrane', 'positive regulation of superoxide anion generation', 'receptor clustering', 'receptor internalization', 'receptor-mediated endocytosis', 'regulation of cell shape', 'regulation of peptidyl-tyrosine phosphorylation']
Glutamate receptor 2
217
Glutamate receptor 2
217
2.0
62
0.79
P19491P19491['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']
Egl nine homolog 1
21
Hypoxia-inducible factor 1-alpha
412
2.0
56
0.88
Q9GZT9Q16665['cardiac muscle tissue morphogenesis', 'cellular iron ion homeostasis', 'cellular response to hypoxia', 'heart trabecula formation', 'labyrinthine layer development', 'negative regulation of cyclic-nucleotide phosphodiesterase activity', 'negative regulation of DNA-binding transcription factor activity', 'oxygen homeostasis', 'peptidyl-proline hydroxylation to 4-hydroxy-L-proline', 'positive regulation of transcription by RNA polymerase II', 'regulation of angiogenesis', 'regulation of neuron death', 'regulation of postsynapse organization', 'regulation of protein catabolic process at postsynapse, modulating synaptic transmission', 'response to hypoxia', 'response to nitric oxide', 'ventricular septum morphogenesis']['angiogenesis', 'axonal transport of mitochondrion', 'B-1 B cell homeostasis', 'bone mineralization', 'cardiac ventricle morphogenesis', 'cellular glucose homeostasis', 'cellular iron ion homeostasis', 'cellular response to hypoxia', 'cellular response to interleukin-1', 'cellular response to virus', 'cerebral cortex development', 'chondrocyte differentiation', 'collagen metabolic process', 'connective tissue replacement involved in inflammatory response wound healing', 'digestive tract morphogenesis', 'dopaminergic neuron differentiation', 'elastin metabolic process', 'embryonic hemopoiesis', 'embryonic placenta development', 'epithelial cell differentiation involved in mammary gland alveolus development', 'epithelial to mesenchymal transition', 'glandular epithelial cell maturation', 'heart looping', 'hemoglobin biosynthetic process', 'hypoxia-inducible factor-1alpha signaling pathway', 'insulin secretion involved in cellular response to glucose stimulus', 'intestinal epithelial cell maturation', 'iris morphogenesis', 'lactate metabolic process', 'lactation', 'mesenchymal cell apoptotic process', 'muscle cell cellular homeostasis', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'negative regulation of growth', 'negative regulation of mesenchymal cell apoptotic process', 'negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of thymocyte apoptotic process', 'negative regulation of TOR signaling', 'neural crest cell migration', 'neural fold elevation formation', 'neuroblast proliferation', 'neuron apoptotic process', 'outflow tract morphogenesis', 'oxygen homeostasis', 'positive regulation of angiogenesis', 'positive regulation of autophagy of mitochondrion', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of chemokine production', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of erythrocyte differentiation', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of hormone biosynthetic process', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of macroautophagy', 'positive regulation of miRNA transcription', 'positive regulation of neuroblast proliferation', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of signaling receptor activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of aerobic respiration', 'regulation of gene expression', 'regulation of glycolytic process', 'regulation of protein neddylation', 'regulation of transcription by RNA polymerase II', 'regulation of transcription from RNA polymerase II promoter in response to oxidative stress', 'regulation of transcription, DNA-templated', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to iron ion', 'response to muscle activity', 'response to reactive oxygen species', 'retina vasculature development in camera-type eye', 'signal transduction', 'TOR signaling', 'vascular endothelial growth factor production', 'visual learning']
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
610
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
267
2.0
61
0.8
Q07343Q07343['cAMP catabolic process', 'cellular response to epinephrine stimulus', 'cellular response to lipopolysaccharide', 'cellular response to xenobiotic stimulus', 'leukocyte migration', 'negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'negative regulation of relaxation of cardiac muscle', 'neutrophil chemotaxis', 'neutrophil homeostasis', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-2 production', 'regulation of cardiac muscle cell contraction', 'regulation of high voltage-gated calcium channel activity', 'signal transduction', 'T cell receptor signaling pathway']['cAMP catabolic process', 'cellular response to epinephrine stimulus', 'cellular response to lipopolysaccharide', 'cellular response to xenobiotic stimulus', 'leukocyte migration', 'negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'negative regulation of relaxation of cardiac muscle', 'neutrophil chemotaxis', 'neutrophil homeostasis', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-2 production', 'regulation of cardiac muscle cell contraction', 'regulation of high voltage-gated calcium channel activity', 'signal transduction', 'T cell receptor signaling pathway']
Cyclin-dependent kinase 5 activator 1
357
Cyclin-dependent kinase 5 activator 1
357
7.9
72
0.18
Q15078Q15078['axon guidance', 'axonal fasciculation', 'brain development', 'cerebellum development', 'embryo development ending in birth or egg hatching', 'ephrin receptor signaling pathway', 'G protein-coupled acetylcholine receptor signaling pathway', 'G1 to G0 transition involved in cell differentiation', 'hippocampus development', 'ionotropic glutamate receptor signaling pathway', 'layer formation in cerebral cortex', 'microtubule cytoskeleton organization', 'negative regulation of transcription, DNA-templated', 'neuron cell-cell adhesion', 'neuron differentiation', 'neuron migration', 'neuron projection development', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of MHC class II biosynthetic process', 'positive regulation of microtubule polymerization', 'positive regulation of neuron apoptotic process', 'positive regulation of protein targeting to membrane', 'positive regulation of signaling receptor activity', 'regulation of actin cytoskeleton organization', 'regulation of cyclin-dependent protein serine/threonine kinase activity', 'regulation of dendritic spine morphogenesis', 'regulation of macroautophagy', 'regulation of neuron differentiation', 'regulation of synaptic vesicle cycle', 'rhythmic process', 'serine phosphorylation of STAT protein', 'superior olivary nucleus maturation']['axon guidance', 'axonal fasciculation', 'brain development', 'cerebellum development', 'embryo development ending in birth or egg hatching', 'ephrin receptor signaling pathway', 'G protein-coupled acetylcholine receptor signaling pathway', 'G1 to G0 transition involved in cell differentiation', 'hippocampus development', 'ionotropic glutamate receptor signaling pathway', 'layer formation in cerebral cortex', 'microtubule cytoskeleton organization', 'negative regulation of transcription, DNA-templated', 'neuron cell-cell adhesion', 'neuron differentiation', 'neuron migration', 'neuron projection development', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of MHC class II biosynthetic process', 'positive regulation of microtubule polymerization', 'positive regulation of neuron apoptotic process', 'positive regulation of protein targeting to membrane', 'positive regulation of signaling receptor activity', 'regulation of actin cytoskeleton organization', 'regulation of cyclin-dependent protein serine/threonine kinase activity', 'regulation of dendritic spine morphogenesis', 'regulation of macroautophagy', 'regulation of neuron differentiation', 'regulation of synaptic vesicle cycle', 'rhythmic process', 'serine phosphorylation of STAT protein', 'superior olivary nucleus maturation']
Immunoglobulin heavy constant gamma 1
356
Immunoglobulin heavy constant gamma 1
349
2.0
63
0.78
P01857P01857['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
Glutamate receptor 2
213
Glutamate receptor 2
213
2.0
62
0.79
P19491P19491['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']
Olfactory receptor 51B2
357
Olfactory receptor 51B2
357
7.7
71
0.18
Q9Y5P1Q9Y5P1[][]
Amyloid-beta precursor protein
21
Amyloid-beta precursor protein
21
5.8
47
0.37
P05067P05067['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Ribosomal oxygenase 1
150
60S ribosomal protein L8
220
1.9
70
0.75
Q9H6W3P62917['chromatin organization', 'histone H3-K36 demethylation', 'histone H3-K4 demethylation', 'negative regulation of osteoblast differentiation', 'negative regulation of transcription, DNA-templated']['cytoplasmic translation', 'translation']
Thioredoxin-dependent peroxide reductase, mitochondrial
78
Thioredoxin-dependent peroxide reductase, mitochondrial
78
3.4
87
0.34
P30048P30048['cell redox homeostasis', 'cellular response to oxidative stress', 'cellular response to reactive oxygen species', 'hydrogen peroxide catabolic process', 'maternal placenta development', 'mitochondrion organization', 'myeloid cell differentiation', 'negative regulation of apoptotic process', 'negative regulation of kinase activity', 'peptidyl-cysteine oxidation', 'positive regulation of cell population proliferation', 'positive regulation of NF-kappaB transcription factor activity', 'regulation of mitochondrial membrane potential', 'response to hydrogen peroxide', 'response to lipopolysaccharide', 'response to oxidative stress']['cell redox homeostasis', 'cellular response to oxidative stress', 'cellular response to reactive oxygen species', 'hydrogen peroxide catabolic process', 'maternal placenta development', 'mitochondrion organization', 'myeloid cell differentiation', 'negative regulation of apoptotic process', 'negative regulation of kinase activity', 'peptidyl-cysteine oxidation', 'positive regulation of cell population proliferation', 'positive regulation of NF-kappaB transcription factor activity', 'regulation of mitochondrial membrane potential', 'response to hydrogen peroxide', 'response to lipopolysaccharide', 'response to oxidative stress']
T cell receptor alpha chain constant
163
T cell receptor beta constant 1
174
2.0
74
0.66
P01848P01850['adaptive immune response', 'alpha-beta T cell activation', 'response to bacterium', 'T cell receptor signaling pathway']['adaptive immune response', 'alpha-beta T cell activation', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'T cell receptor signaling pathway']
Bcl-2 homologous antagonist/killer
184
Bcl-2 homologous antagonist/killer
92
2.0
nan
nan
Q16611Q16611['activation of cysteine-type endopeptidase activity', 'activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c', 'aging', 'animal organ regeneration', 'apoptotic process', 'apoptotic process involved in blood vessel morphogenesis', 'apoptotic signaling pathway', 'B cell apoptotic process', 'B cell homeostasis', 'B cell negative selection', 'blood vessel remodeling', 'brain development', 'calcium ion transport into cytosol', 'cellular response to mechanical stimulus', 'cellular response to unfolded protein', 'cellular response to UV', 'endocrine pancreas development', 'endoplasmic reticulum calcium ion homeostasis', 'epithelial cell proliferation', 'establishment or maintenance of transmembrane electrochemical gradient', 'extrinsic apoptotic signaling pathway in absence of ligand', 'fibroblast apoptotic process', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'limb morphogenesis', 'mitochondrial fusion', 'myeloid cell homeostasis', 'negative regulation of cell population proliferation', 'negative regulation of endoplasmic reticulum calcium ion concentration', 'negative regulation of gene expression', 'negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'peptidyl-serine phosphorylation', 'positive regulation of apoptotic process', 'positive regulation of calcium ion transport into cytosol', 'positive regulation of endoplasmic reticulum unfolded protein response', 'positive regulation of IRE1-mediated unfolded protein response', 'positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway', 'positive regulation of protein-containing complex assembly', 'positive regulation of proteolysis', 'positive regulation of release of cytochrome c from mitochondria', 'post-embryonic camera-type eye morphogenesis', 'regulation of cell cycle', 'regulation of mitochondrial membrane permeability', 'regulation of mitochondrial membrane potential', 'release of cytochrome c from mitochondria', 'response to ethanol', 'response to fungus', 'response to gamma radiation', 'response to hydrogen peroxide', 'response to mycotoxin', 'response to organic cyclic compound', 'response to UV-C', 'response to xenobiotic stimulus', 'thymocyte apoptotic process', 'vagina development']['activation of cysteine-type endopeptidase activity', 'activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c', 'aging', 'animal organ regeneration', 'apoptotic process', 'apoptotic process involved in blood vessel morphogenesis', 'apoptotic signaling pathway', 'B cell apoptotic process', 'B cell homeostasis', 'B cell negative selection', 'blood vessel remodeling', 'brain development', 'calcium ion transport into cytosol', 'cellular response to mechanical stimulus', 'cellular response to unfolded protein', 'cellular response to UV', 'endocrine pancreas development', 'endoplasmic reticulum calcium ion homeostasis', 'epithelial cell proliferation', 'establishment or maintenance of transmembrane electrochemical gradient', 'extrinsic apoptotic signaling pathway in absence of ligand', 'fibroblast apoptotic process', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'limb morphogenesis', 'mitochondrial fusion', 'myeloid cell homeostasis', 'negative regulation of cell population proliferation', 'negative regulation of endoplasmic reticulum calcium ion concentration', 'negative regulation of gene expression', 'negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'peptidyl-serine phosphorylation', 'positive regulation of apoptotic process', 'positive regulation of calcium ion transport into cytosol', 'positive regulation of endoplasmic reticulum unfolded protein response', 'positive regulation of IRE1-mediated unfolded protein response', 'positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway', 'positive regulation of protein-containing complex assembly', 'positive regulation of proteolysis', 'positive regulation of release of cytochrome c from mitochondria', 'post-embryonic camera-type eye morphogenesis', 'regulation of cell cycle', 'regulation of mitochondrial membrane permeability', 'regulation of mitochondrial membrane potential', 'release of cytochrome c from mitochondria', 'response to ethanol', 'response to fungus', 'response to gamma radiation', 'response to hydrogen peroxide', 'response to mycotoxin', 'response to organic cyclic compound', 'response to UV-C', 'response to xenobiotic stimulus', 'thymocyte apoptotic process', 'vagina development']
T cell receptor alpha chain constant
156
T cell receptor beta constant 1
167
2.0
78
0.63
P01848P01850['adaptive immune response', 'alpha-beta T cell activation', 'response to bacterium', 'T cell receptor signaling pathway']['adaptive immune response', 'alpha-beta T cell activation', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'T cell receptor signaling pathway']
Ubiquitin-40S ribosomal protein S27a
76
Histone H3.1
18
2.0
nan
nan
P62979P68431['cytoplasmic translation', 'modification-dependent protein catabolic process', 'protein ubiquitination', 'translation']['DNA replication-dependent chromatin assembly', 'nucleosome assembly', 'regulation of gene expression, epigenetic', 'telomere organization']
MHC class II HLA-DQ-alpha chain
72
HLA class II histocompatibility antigen DQ beta chain
-15
2.2
59
0.76
Q30069U3PYM0['adaptive immune response', 'antigen processing and presentation of peptide or polysaccharide antigen via MHC class II']['adaptive immune response', 'antigen processing and presentation of peptide or polysaccharide antigen via MHC class II']
T cell receptor alpha chain constant
160
T cell receptor beta constant 2
170
2.0
79
0.62
P01848A0A5B9['adaptive immune response', 'alpha-beta T cell activation', 'response to bacterium', 'T cell receptor signaling pathway']['adaptive immune response', 'alpha-beta T cell activation', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'T cell receptor signaling pathway']
Bifunctional peptidase and arginyl-hydroxylase JMJD5
275
40S ribosomal protein S6
138
2.0
nan
nan
Q8N371P62753['chromatin organization', 'circadian regulation of gene expression', 'G2/M transition of mitotic cell cycle', 'histone H3-K36 demethylation', 'negative regulation of transcription, DNA-templated', 'positive regulation of transcription, DNA-templated', 'protein destabilization', 'proteolysis']['activation-induced cell death of T cells', 'cytoplasmic translation', 'erythrocyte development', 'G1/S transition of mitotic cell cycle', 'gastrulation', 'glucose homeostasis', 'mammalian oogenesis stage', 'negative regulation of apoptotic process', 'placenta development', 'positive regulation of apoptotic process', 'positive regulation of cell population proliferation', 'ribosomal small subunit biogenesis', 'rRNA processing', 'T cell differentiation in thymus', 'T cell proliferation involved in immune response', 'TOR signaling', 'translation']
Peroxiredoxin-1
185
Sulfiredoxin-1
43
2.1
56
0.86
Q06830Q9BYN0['cell population proliferation', 'cell redox homeostasis', 'erythrocyte homeostasis', 'fibroblast proliferation', 'hydrogen peroxide catabolic process', 'leukocyte activation', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'regulation of NIK/NF-kappaB signaling', 'regulation of stress-activated MAPK cascade', 'removal of superoxide radicals', 'retina homeostasis', 'skeletal system development']['cellular response to oxidative stress', 'response to oxidative stress']
T cell receptor alpha chain constant
164
T cell receptor beta constant 2
168
2.1
73
0.67
P01848A0A5B9['adaptive immune response', 'alpha-beta T cell activation', 'response to bacterium', 'T cell receptor signaling pathway']['adaptive immune response', 'alpha-beta T cell activation', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'T cell receptor signaling pathway']
T cell receptor alpha chain constant
162
T cell receptor beta constant 1
169
2.0
74
0.67
P01848P01850['adaptive immune response', 'alpha-beta T cell activation', 'response to bacterium', 'T cell receptor signaling pathway']['adaptive immune response', 'alpha-beta T cell activation', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'T cell receptor signaling pathway']
Bcl-2 homologous antagonist/killer
184
BH3-interacting domain death agonist
104
2.1
nan
nan
Q16611P55957['activation of cysteine-type endopeptidase activity', 'activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c', 'aging', 'animal organ regeneration', 'apoptotic process', 'apoptotic process involved in blood vessel morphogenesis', 'apoptotic signaling pathway', 'B cell apoptotic process', 'B cell homeostasis', 'B cell negative selection', 'blood vessel remodeling', 'brain development', 'calcium ion transport into cytosol', 'cellular response to mechanical stimulus', 'cellular response to unfolded protein', 'cellular response to UV', 'endocrine pancreas development', 'endoplasmic reticulum calcium ion homeostasis', 'epithelial cell proliferation', 'establishment or maintenance of transmembrane electrochemical gradient', 'extrinsic apoptotic signaling pathway in absence of ligand', 'fibroblast apoptotic process', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'limb morphogenesis', 'mitochondrial fusion', 'myeloid cell homeostasis', 'negative regulation of cell population proliferation', 'negative regulation of endoplasmic reticulum calcium ion concentration', 'negative regulation of gene expression', 'negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'peptidyl-serine phosphorylation', 'positive regulation of apoptotic process', 'positive regulation of calcium ion transport into cytosol', 'positive regulation of endoplasmic reticulum unfolded protein response', 'positive regulation of IRE1-mediated unfolded protein response', 'positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway', 'positive regulation of protein-containing complex assembly', 'positive regulation of proteolysis', 'positive regulation of release of cytochrome c from mitochondria', 'post-embryonic camera-type eye morphogenesis', 'regulation of cell cycle', 'regulation of mitochondrial membrane permeability', 'regulation of mitochondrial membrane potential', 'release of cytochrome c from mitochondria', 'response to ethanol', 'response to fungus', 'response to gamma radiation', 'response to hydrogen peroxide', 'response to mycotoxin', 'response to organic cyclic compound', 'response to UV-C', 'response to xenobiotic stimulus', 'thymocyte apoptotic process', 'vagina development']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'apoptotic mitochondrial changes', 'establishment of protein localization to membrane', 'extrinsic apoptotic signaling pathway via death domain receptors', 'hepatocyte apoptotic process', 'mitochondrial ATP synthesis coupled electron transport', 'mitochondrial outer membrane permeabilization', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'neuron apoptotic process', 'positive regulation of apoptotic process', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of fibroblast apoptotic process', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of mitochondrial membrane potential', 'positive regulation of protein-containing complex assembly', 'positive regulation of release of cytochrome c from mitochondria', 'protein targeting to mitochondrion', 'protein-containing complex assembly', 'regulation of epithelial cell proliferation', 'regulation of G1/S transition of mitotic cell cycle', 'regulation of T cell proliferation', 'release of cytochrome c from mitochondria', 'signal transduction in response to DNA damage', 'supramolecular fiber organization']
T cell receptor beta constant 1
175
T cell receptor alpha chain constant
163
2.0
73
0.67
P01850P01848['adaptive immune response', 'alpha-beta T cell activation', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'T cell receptor signaling pathway']['adaptive immune response', 'alpha-beta T cell activation', 'response to bacterium', 'T cell receptor signaling pathway']
T cell receptor alpha chain constant
158
T cell receptor beta constant 1
171
2.0
73
0.67
P01848P01850['adaptive immune response', 'alpha-beta T cell activation', 'response to bacterium', 'T cell receptor signaling pathway']['adaptive immune response', 'alpha-beta T cell activation', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'T cell receptor signaling pathway']
Retinol-binding protein 2
32
Retinol-binding protein 2
32
2.0
62
0.79
P50120P50120['epidermis development', 'fatty acid transport', 'vitamin A metabolic process']['epidermis development', 'fatty acid transport', 'vitamin A metabolic process']
Podoplanin
nan
Podoplanin
nan
2.0
nan
nan
Q86YL7Q86YL7['actin-mediated cell contraction', 'cell migration', 'cell morphogenesis', 'cell-cell adhesion', 'lung development', 'lymph node development', 'lymphangiogenesis', 'lymphatic endothelial cell fate commitment', 'negative regulation of apoptotic process', 'negative regulation of cell population proliferation', 'platelet activation', 'positive regulation of cell migration', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of extracellular matrix disassembly', 'positive regulation of platelet aggregation', 'regulation of cell shape', 'regulation of lamellipodium morphogenesis', 'regulation of myofibroblast contraction', 'regulation of substrate adhesion-dependent cell spreading', 'response to hyperoxia', 'Rho protein signal transduction', 'wound healing, spreading of cells']['actin-mediated cell contraction', 'cell migration', 'cell morphogenesis', 'cell-cell adhesion', 'lung development', 'lymph node development', 'lymphangiogenesis', 'lymphatic endothelial cell fate commitment', 'negative regulation of apoptotic process', 'negative regulation of cell population proliferation', 'platelet activation', 'positive regulation of cell migration', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of extracellular matrix disassembly', 'positive regulation of platelet aggregation', 'regulation of cell shape', 'regulation of lamellipodium morphogenesis', 'regulation of myofibroblast contraction', 'regulation of substrate adhesion-dependent cell spreading', 'response to hyperoxia', 'Rho protein signal transduction', 'wound healing, spreading of cells']
Polyubiquitin-B
nan
Histone H3.3
18
2.0
nan
nan
J3QS39P84243[]['cell population proliferation', 'DNA replication-independent chromatin assembly', 'embryo implantation', 'histone H3-S10 phosphorylation', 'histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore', 'male gonad development', 'multicellular organism growth', 'muscle cell differentiation', 'negative regulation of chromosome condensation', 'nucleosome assembly', 'nucleus organization', 'oocyte maturation', 'osteoblast differentiation', 'pericentric heterochromatin assembly', 'positive regulation of cell growth', 'regulation of centromere complex assembly', 'single fertilization', 'spermatid development', 'subtelomeric heterochromatin assembly', 'telomere organization']
Ubiquitin-conjugating enzyme E2 N
87
Polyubiquitin-C
nan
2.0
nan
nan
P61088P0CG48['DNA double-strand break processing', 'double-strand break repair via homologous recombination', 'histone ubiquitination', 'positive regulation of DNA repair', 'positive regulation of double-strand break repair', 'positive regulation of histone modification', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of intracellular signal transduction', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein K63-linked ubiquitination', 'positive regulation of ubiquitin-protein transferase activity', 'postreplication repair', 'protein K63-linked ubiquitination', 'protein polyubiquitination', 'protein ubiquitination', 'regulation of DNA repair', 'regulation of histone ubiquitination', 'T cell receptor signaling pathway', 'ubiquitin-dependent protein catabolic process']['modification-dependent protein catabolic process', 'protein ubiquitination']
Alpha-crystallin B chain
nan
Alpha-crystallin B chain
nan
2.0
59
0.83
P02511P02511['apoptotic process involved in morphogenesis', 'cellular response to gamma radiation', 'lens development in camera-type eye', 'microtubule polymerization or depolymerization', 'multicellular organism aging', 'muscle contraction', 'muscle organ development', 'negative regulation of amyloid fibril formation', 'negative regulation of apoptotic process', 'negative regulation of cell growth', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of gene expression', 'negative regulation of intracellular transport', 'negative regulation of protein-containing complex assembly', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of transcription, DNA-templated', 'protein folding', 'protein refolding', 'protein stabilization', 'regulation of cell death', 'response to estradiol', 'response to heat', 'response to hydrogen peroxide', 'response to hypoxia', 'stress-activated MAPK cascade', 'tubulin complex assembly']['apoptotic process involved in morphogenesis', 'cellular response to gamma radiation', 'lens development in camera-type eye', 'microtubule polymerization or depolymerization', 'multicellular organism aging', 'muscle contraction', 'muscle organ development', 'negative regulation of amyloid fibril formation', 'negative regulation of apoptotic process', 'negative regulation of cell growth', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of gene expression', 'negative regulation of intracellular transport', 'negative regulation of protein-containing complex assembly', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of transcription, DNA-templated', 'protein folding', 'protein refolding', 'protein stabilization', 'regulation of cell death', 'response to estradiol', 'response to heat', 'response to hydrogen peroxide', 'response to hypoxia', 'stress-activated MAPK cascade', 'tubulin complex assembly']
Myc proto-oncogene protein
438
Protein max
nan
3.0
nan
nan
P01106P61244['branching involved in ureteric bud morphogenesis', 'cellular iron ion homeostasis', 'cellular response to DNA damage stimulus', 'cellular response to hypoxia', 'cellular response to UV', 'cellular response to xenobiotic stimulus', 'chromatin remodeling', 'chromosome organization', 'energy reserve metabolic process', 'ERK1 and ERK2 cascade', 'fibroblast apoptotic process', 'G1/S transition of mitotic cell cycle', 'MAPK cascade', 'negative regulation of apoptotic process', 'negative regulation of cell division', 'negative regulation of fibroblast proliferation', 'negative regulation of monocyte differentiation', 'negative regulation of stress-activated MAPK cascade', 'negative regulation of transcription by RNA polymerase II', 'oxygen transport', 'positive regulation of cell population proliferation', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of DNA biosynthetic process', 'positive regulation of DNA methylation', 'positive regulation of epithelial cell proliferation', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'positive regulation of mesenchymal cell proliferation', 'positive regulation of metanephric cap mesenchymal cell proliferation', 'positive regulation of miRNA transcription', 'positive regulation of response to DNA damage stimulus', 'positive regulation of telomerase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein-DNA complex disassembly', 'regulation of cell cycle process', 'regulation of gene expression', 'regulation of somatic stem cell population maintenance', 'regulation of telomere maintenance', 'regulation of transcription by RNA polymerase II', 'response to gamma radiation', 'response to growth factor', 'response to xenobiotic stimulus']['cellular response to peptide hormone stimulus', 'cellular response to starvation', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein-containing complex assembly', 'regulation of transcription by RNA polymerase II', 'response to axon injury', 'response to insulin', 'retina development in camera-type eye']
Galectin-7
16
Galectin-7
16
1.9
70
0.76
P47929P47929['apoptotic process', 'heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules', 'negative regulation of CD4-positive, alpha-beta T cell proliferation', 'negative regulation of interferon-gamma production', 'positive regulation of gene expression']['apoptotic process', 'heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules', 'negative regulation of CD4-positive, alpha-beta T cell proliferation', 'negative regulation of interferon-gamma production', 'positive regulation of gene expression']
Vimentin
265
Vimentin
265
2.0
38
1.29
P08670P08670['astrocyte development', 'Bergmann glial cell differentiation', 'cellular response to interferon-gamma', 'cellular response to lipopolysaccharide', 'cellular response to muramyl dipeptide', 'intermediate filament organization', 'lens fiber cell development', 'negative regulation of neuron projection development', 'neuron projection development', 'positive regulation of collagen biosynthetic process', 'positive regulation of translation', 'regulation of mRNA stability', 'SMAD protein signal transduction']['astrocyte development', 'Bergmann glial cell differentiation', 'cellular response to interferon-gamma', 'cellular response to lipopolysaccharide', 'cellular response to muramyl dipeptide', 'intermediate filament organization', 'lens fiber cell development', 'negative regulation of neuron projection development', 'neuron projection development', 'positive regulation of collagen biosynthetic process', 'positive regulation of translation', 'regulation of mRNA stability', 'SMAD protein signal transduction']
Glutathione S-transferase A1
101
Glutathione S-transferase A1
101
5.8
44
0.39
P08263P08263['epithelial cell differentiation', 'glutathione derivative biosynthetic process', 'glutathione metabolic process', 'linoleic acid metabolic process', 'prostaglandin metabolic process', 'xenobiotic metabolic process']['epithelial cell differentiation', 'glutathione derivative biosynthetic process', 'glutathione metabolic process', 'linoleic acid metabolic process', 'prostaglandin metabolic process', 'xenobiotic metabolic process']
Kinetochore protein Spc25
232
Kinetochore protein Spc24
134
4.4
67
0.34
Q9HBM1Q8NBT2['attachment of spindle microtubules to kinetochore', 'cell division', 'chromosome segregation', 'mitotic spindle assembly checkpoint signaling', 'mitotic spindle organization']['attachment of spindle microtubules to kinetochore', 'cell division', 'chromosome segregation', 'mitotic spindle assembly checkpoint signaling']
Polyubiquitin-B
46
Polyubiquitin-B
46
2.0
48
1.02
P0CG47P0CG47['energy homeostasis', 'fat pad development', 'female gonad development', 'female meiosis I', 'hypothalamus gonadotrophin-releasing hormone neuron development', 'male meiosis I', 'mitochondrion transport along microtubule', 'modification-dependent protein catabolic process', 'neuron projection morphogenesis', 'positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'positive regulation of protein monoubiquitination', 'positive regulation of protein ubiquitination', 'protein ubiquitination', 'regulation of mitochondrial membrane potential', 'regulation of neuron death', 'regulation of proteasomal protein catabolic process', 'seminiferous tubule development']['energy homeostasis', 'fat pad development', 'female gonad development', 'female meiosis I', 'hypothalamus gonadotrophin-releasing hormone neuron development', 'male meiosis I', 'mitochondrion transport along microtubule', 'modification-dependent protein catabolic process', 'neuron projection morphogenesis', 'positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'positive regulation of protein monoubiquitination', 'positive regulation of protein ubiquitination', 'protein ubiquitination', 'regulation of mitochondrial membrane potential', 'regulation of neuron death', 'regulation of proteasomal protein catabolic process', 'seminiferous tubule development']
GTPase KRas
70
GTPase KRas
70
6.6
61
0.25
P01116P01116['actin cytoskeleton organization', 'endocrine signaling', 'epithelial tube branching involved in lung morphogenesis', 'forebrain astrocyte development', 'glial cell proliferation', 'homeostasis of number of cells within a tissue', 'MAPK cascade', 'negative regulation of epithelial cell differentiation', 'negative regulation of neuron apoptotic process', 'neuron apoptotic process', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of glial cell proliferation', 'positive regulation of protein phosphorylation', 'positive regulation of Rac protein signal transduction', 'Rac protein signal transduction', 'Ras protein signal transduction', 'regulation of long-term neuronal synaptic plasticity', 'regulation of protein stability', 'regulation of synaptic transmission, GABAergic', 'skeletal muscle cell differentiation', 'striated muscle cell differentiation', 'type I pneumocyte differentiation', 'visual learning']['actin cytoskeleton organization', 'endocrine signaling', 'epithelial tube branching involved in lung morphogenesis', 'forebrain astrocyte development', 'glial cell proliferation', 'homeostasis of number of cells within a tissue', 'MAPK cascade', 'negative regulation of epithelial cell differentiation', 'negative regulation of neuron apoptotic process', 'neuron apoptotic process', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of glial cell proliferation', 'positive regulation of protein phosphorylation', 'positive regulation of Rac protein signal transduction', 'Rac protein signal transduction', 'Ras protein signal transduction', 'regulation of long-term neuronal synaptic plasticity', 'regulation of protein stability', 'regulation of synaptic transmission, GABAergic', 'skeletal muscle cell differentiation', 'striated muscle cell differentiation', 'type I pneumocyte differentiation', 'visual learning']
Beta-2-microglobulin
20
Beta-2-microglobulin
20
2.0
58
0.85
P61769P61769['amyloid fibril formation', 'antibacterial humoral response', 'antigen processing and presentation of endogenous peptide antigen via MHC class I', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to iron ion', 'cellular response to iron(III) ion', 'cellular response to lipopolysaccharide', 'cellular response to nicotine', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'iron ion homeostasis', 'iron ion transport', 'learning or memory', 'negative regulation of epithelial cell proliferation', 'negative regulation of forebrain neuron differentiation', 'negative regulation of neurogenesis', 'negative regulation of neuron projection development', 'negative regulation of receptor binding', 'peptide antigen assembly with MHC class II protein complex', 'positive regulation of cellular senescence', 'positive regulation of ferrous iron binding', 'positive regulation of protein binding', 'positive regulation of receptor binding', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of T cell activation', 'positive regulation of T cell cytokine production', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of transferrin receptor binding', 'protein homotetramerization', 'protein refolding', 'regulation of erythrocyte differentiation', 'regulation of iron ion transport', 'regulation of membrane depolarization', 'response to molecule of bacterial origin', 'retina homeostasis', 'sensory perception of smell', 'T cell differentiation in thymus', 'T cell mediated cytotoxicity']['amyloid fibril formation', 'antibacterial humoral response', 'antigen processing and presentation of endogenous peptide antigen via MHC class I', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to iron ion', 'cellular response to iron(III) ion', 'cellular response to lipopolysaccharide', 'cellular response to nicotine', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'iron ion homeostasis', 'iron ion transport', 'learning or memory', 'negative regulation of epithelial cell proliferation', 'negative regulation of forebrain neuron differentiation', 'negative regulation of neurogenesis', 'negative regulation of neuron projection development', 'negative regulation of receptor binding', 'peptide antigen assembly with MHC class II protein complex', 'positive regulation of cellular senescence', 'positive regulation of ferrous iron binding', 'positive regulation of protein binding', 'positive regulation of receptor binding', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of T cell activation', 'positive regulation of T cell cytokine production', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of transferrin receptor binding', 'protein homotetramerization', 'protein refolding', 'regulation of erythrocyte differentiation', 'regulation of iron ion transport', 'regulation of membrane depolarization', 'response to molecule of bacterial origin', 'retina homeostasis', 'sensory perception of smell', 'T cell differentiation in thymus', 'T cell mediated cytotoxicity']
Neutrophil defensin 1
1
Neutrophil defensin 1
1
2.0
nan
nan
P59665P59665['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']
Beta-2-microglobulin
50
Beta-2-microglobulin
50
2.0
60
0.83
P61769P61769['amyloid fibril formation', 'antibacterial humoral response', 'antigen processing and presentation of endogenous peptide antigen via MHC class I', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to iron ion', 'cellular response to iron(III) ion', 'cellular response to lipopolysaccharide', 'cellular response to nicotine', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'iron ion homeostasis', 'iron ion transport', 'learning or memory', 'negative regulation of epithelial cell proliferation', 'negative regulation of forebrain neuron differentiation', 'negative regulation of neurogenesis', 'negative regulation of neuron projection development', 'negative regulation of receptor binding', 'peptide antigen assembly with MHC class II protein complex', 'positive regulation of cellular senescence', 'positive regulation of ferrous iron binding', 'positive regulation of protein binding', 'positive regulation of receptor binding', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of T cell activation', 'positive regulation of T cell cytokine production', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of transferrin receptor binding', 'protein homotetramerization', 'protein refolding', 'regulation of erythrocyte differentiation', 'regulation of iron ion transport', 'regulation of membrane depolarization', 'response to molecule of bacterial origin', 'retina homeostasis', 'sensory perception of smell', 'T cell differentiation in thymus', 'T cell mediated cytotoxicity']['amyloid fibril formation', 'antibacterial humoral response', 'antigen processing and presentation of endogenous peptide antigen via MHC class I', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to iron ion', 'cellular response to iron(III) ion', 'cellular response to lipopolysaccharide', 'cellular response to nicotine', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'iron ion homeostasis', 'iron ion transport', 'learning or memory', 'negative regulation of epithelial cell proliferation', 'negative regulation of forebrain neuron differentiation', 'negative regulation of neurogenesis', 'negative regulation of neuron projection development', 'negative regulation of receptor binding', 'peptide antigen assembly with MHC class II protein complex', 'positive regulation of cellular senescence', 'positive regulation of ferrous iron binding', 'positive regulation of protein binding', 'positive regulation of receptor binding', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of T cell activation', 'positive regulation of T cell cytokine production', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of transferrin receptor binding', 'protein homotetramerization', 'protein refolding', 'regulation of erythrocyte differentiation', 'regulation of iron ion transport', 'regulation of membrane depolarization', 'response to molecule of bacterial origin', 'retina homeostasis', 'sensory perception of smell', 'T cell differentiation in thymus', 'T cell mediated cytotoxicity']
Ribonuclease pancreatic
31
Ribonuclease pancreatic
31
7.0
70
0.2
P07998P07998['defense response to Gram-positive bacterium', 'RNA phosphodiester bond hydrolysis']['defense response to Gram-positive bacterium', 'RNA phosphodiester bond hydrolysis']
Bis(5'-adenosyl)-triphosphatase
8
Bis(5'-adenosyl)-triphosphatase
8
5.4
50
0.37
P49789P49789['diadenosine triphosphate catabolic process', 'intrinsic apoptotic signaling pathway by p53 class mediator', 'negative regulation of proteasomal ubiquitin-dependent protein catabolic process', 'purine nucleotide metabolic process']['diadenosine triphosphate catabolic process', 'intrinsic apoptotic signaling pathway by p53 class mediator', 'negative regulation of proteasomal ubiquitin-dependent protein catabolic process', 'purine nucleotide metabolic process']
T-cell receptor alpha chain C region
166
T-cell receptor beta-1 chain C region
168
2.0
72
0.68
P01849P01852['protein homotetramerization', 'response to bacterium', 'T cell lineage commitment']['B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
Polyubiquitin-B
48
Polyubiquitin-B
48
3.9
67
0.39
P0CG47P0CG47['energy homeostasis', 'fat pad development', 'female gonad development', 'female meiosis I', 'hypothalamus gonadotrophin-releasing hormone neuron development', 'male meiosis I', 'mitochondrion transport along microtubule', 'modification-dependent protein catabolic process', 'neuron projection morphogenesis', 'positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'positive regulation of protein monoubiquitination', 'positive regulation of protein ubiquitination', 'protein ubiquitination', 'regulation of mitochondrial membrane potential', 'regulation of neuron death', 'regulation of proteasomal protein catabolic process', 'seminiferous tubule development']['energy homeostasis', 'fat pad development', 'female gonad development', 'female meiosis I', 'hypothalamus gonadotrophin-releasing hormone neuron development', 'male meiosis I', 'mitochondrion transport along microtubule', 'modification-dependent protein catabolic process', 'neuron projection morphogenesis', 'positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'positive regulation of protein monoubiquitination', 'positive regulation of protein ubiquitination', 'protein ubiquitination', 'regulation of mitochondrial membrane potential', 'regulation of neuron death', 'regulation of proteasomal protein catabolic process', 'seminiferous tubule development']
LIM domain-binding protein 1
56
LIM domain-binding protein 1
56
2.0
57
0.87
P70662P70662['anterior/posterior axis specification', 'cell adhesion', 'cell differentiation', 'cellular component assembly', 'cerebellar Purkinje cell differentiation', 'cerebellum development', 'epithelial structure maintenance', 'gastrulation with mouth forming second', 'hair follicle development', 'head development', 'histone H3-K4 acetylation', 'mesendoderm development', 'negative regulation of erythrocyte differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'nervous system development', 'neuron differentiation', 'positive regulation of cell adhesion', 'positive regulation of hemoglobin biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'primitive erythrocyte differentiation', 'regulation of cell migration', 'regulation of focal adhesion assembly', 'regulation of kinase activity', 'regulation of transcription elongation from RNA polymerase II promoter', 'somatic stem cell population maintenance', 'transcription by RNA polymerase II', 'transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery', 'Wnt signaling pathway']['anterior/posterior axis specification', 'cell adhesion', 'cell differentiation', 'cellular component assembly', 'cerebellar Purkinje cell differentiation', 'cerebellum development', 'epithelial structure maintenance', 'gastrulation with mouth forming second', 'hair follicle development', 'head development', 'histone H3-K4 acetylation', 'mesendoderm development', 'negative regulation of erythrocyte differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'nervous system development', 'neuron differentiation', 'positive regulation of cell adhesion', 'positive regulation of hemoglobin biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'primitive erythrocyte differentiation', 'regulation of cell migration', 'regulation of focal adhesion assembly', 'regulation of kinase activity', 'regulation of transcription elongation from RNA polymerase II promoter', 'somatic stem cell population maintenance', 'transcription by RNA polymerase II', 'transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery', 'Wnt signaling pathway']
Ubiquitin-conjugating enzyme E2 K
124
Polyubiquitin-B
48
8.3
45
0.27
P61086P0CG47['cellular response to interferon-beta', 'free ubiquitin chain polymerization', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of tumor necrosis factor-mediated signaling pathway', 'positive regulation of type I interferon-mediated signaling pathway', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein K48-linked ubiquitination', 'protein polyubiquitination', 'regulation of proteasomal ubiquitin-dependent protein catabolic process', 'ubiquitin-dependent protein catabolic process']['energy homeostasis', 'fat pad development', 'female gonad development', 'female meiosis I', 'hypothalamus gonadotrophin-releasing hormone neuron development', 'male meiosis I', 'mitochondrion transport along microtubule', 'modification-dependent protein catabolic process', 'neuron projection morphogenesis', 'positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'positive regulation of protein monoubiquitination', 'positive regulation of protein ubiquitination', 'protein ubiquitination', 'regulation of mitochondrial membrane potential', 'regulation of neuron death', 'regulation of proteasomal protein catabolic process', 'seminiferous tubule development']
Mitogen-activated protein kinase 1
116
Tyrosine-protein phosphatase non-receptor type 7
31
2.0
nan
nan
P63086P35236['aging', 'animal organ morphogenesis', 'apoptotic process', 'B cell receptor signaling pathway', 'Bergmann glial cell differentiation', 'cardiac neural crest cell development involved in heart development', 'caveolin-mediated endocytosis', 'cell cycle', 'cell surface receptor signaling pathway', 'cellular response to amino acid starvation', 'cellular response to cadmium ion', 'cellular response to DNA damage stimulus', 'cellular response to dopamine', 'cellular response to granulocyte macrophage colony-stimulating factor stimulus', 'cellular response to organic substance', 'cellular response to reactive oxygen species', 'cellular response to tumor necrosis factor', 'cytosine metabolic process', 'decidualization', 'diadenosine tetraphosphate biosynthetic process', 'ERBB signaling pathway', 'ERK1 and ERK2 cascade', 'face development', 'heart development', 'intracellular signal transduction', 'labyrinthine layer blood vessel development', 'lipopolysaccharide-mediated signaling pathway', 'long-term synaptic potentiation', 'lung morphogenesis', 'mammary gland epithelial cell proliferation', 'MAPK cascade', 'negative regulation of cell differentiation', 'neural crest cell development', 'outer ear morphogenesis', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of macrophage chemotaxis', 'positive regulation of macrophage proliferation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of telomerase activity', 'positive regulation of telomere capping', 'positive regulation of telomere maintenance via telomerase', 'positive regulation of transcription, DNA-templated', 'positive regulation of translation', 'protein phosphorylation', 'regulation of cellular pH', 'regulation of cytoskeleton organization', 'regulation of early endosome to late endosome transport', 'regulation of Golgi inheritance', 'regulation of ossification', 'regulation of protein stability', 'regulation of stress-activated MAPK cascade', 'response to epidermal growth factor', 'response to estrogen', 'response to exogenous dsRNA', 'response to lipopolysaccharide', 'response to nicotine', 'response to toxic substance', 'sensory perception of pain', 'signal transduction', 'stress-activated MAPK cascade', 'T cell receptor signaling pathway', 'thymus development', 'thyroid gland development', 'trachea formation']['MAPK cascade', 'protein dephosphorylation']
C-C motif chemokine 20
64
C-C motif chemokine 20
64
2.0
68
0.73
P78556P78556['antimicrobial humoral immune response mediated by antimicrobial peptide', 'calcium-mediated signaling using intracellular calcium source', 'cell chemotaxis', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response to bacterium', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of T cell migration', 'signal transduction', 'T cell migration', 'thymocyte migration']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'calcium-mediated signaling using intracellular calcium source', 'cell chemotaxis', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response to bacterium', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of T cell migration', 'signal transduction', 'T cell migration', 'thymocyte migration']
Kinetochore protein Spc25
137
Kinetochore protein Spc24
111
7.9
54
0.24
Q9HBM1Q8NBT2['attachment of spindle microtubules to kinetochore', 'cell division', 'chromosome segregation', 'mitotic spindle assembly checkpoint signaling', 'mitotic spindle organization']['attachment of spindle microtubules to kinetochore', 'cell division', 'chromosome segregation', 'mitotic spindle assembly checkpoint signaling']
Retinol-binding protein 2
36
Retinol-binding protein 2
36
7.9
62
0.2
P50120P50120['epidermis development', 'fatty acid transport', 'vitamin A metabolic process']['epidermis development', 'fatty acid transport', 'vitamin A metabolic process']
LIM domain-binding protein 1
48
LIM domain-binding protein 1
48
7.9
63
0.2
P70662P70662['anterior/posterior axis specification', 'cell adhesion', 'cell differentiation', 'cellular component assembly', 'cerebellar Purkinje cell differentiation', 'cerebellum development', 'epithelial structure maintenance', 'gastrulation with mouth forming second', 'hair follicle development', 'head development', 'histone H3-K4 acetylation', 'mesendoderm development', 'negative regulation of erythrocyte differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'nervous system development', 'neuron differentiation', 'positive regulation of cell adhesion', 'positive regulation of hemoglobin biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'primitive erythrocyte differentiation', 'regulation of cell migration', 'regulation of focal adhesion assembly', 'regulation of kinase activity', 'regulation of transcription elongation from RNA polymerase II promoter', 'somatic stem cell population maintenance', 'transcription by RNA polymerase II', 'transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery', 'Wnt signaling pathway']['anterior/posterior axis specification', 'cell adhesion', 'cell differentiation', 'cellular component assembly', 'cerebellar Purkinje cell differentiation', 'cerebellum development', 'epithelial structure maintenance', 'gastrulation with mouth forming second', 'hair follicle development', 'head development', 'histone H3-K4 acetylation', 'mesendoderm development', 'negative regulation of erythrocyte differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'nervous system development', 'neuron differentiation', 'positive regulation of cell adhesion', 'positive regulation of hemoglobin biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'primitive erythrocyte differentiation', 'regulation of cell migration', 'regulation of focal adhesion assembly', 'regulation of kinase activity', 'regulation of transcription elongation from RNA polymerase II promoter', 'somatic stem cell population maintenance', 'transcription by RNA polymerase II', 'transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery', 'Wnt signaling pathway']
Phospholipase A and acyltransferase 3
67
Phospholipase A and acyltransferase 3
67
5.0
73
0.27
P53816P53816['ether lipid metabolic process', 'lens fiber cell differentiation', 'lipid catabolic process', 'membrane disassembly', 'N-acylphosphatidylethanolamine metabolic process', 'organelle disassembly', 'peroxisome organization', 'phosphatidylethanolamine acyl-chain remodeling', 'phospholipid biosynthetic process', 'phospholipid metabolic process', 'regulation of adipose tissue development', 'response to bacterium', 'triglyceride metabolic process']['ether lipid metabolic process', 'lens fiber cell differentiation', 'lipid catabolic process', 'membrane disassembly', 'N-acylphosphatidylethanolamine metabolic process', 'organelle disassembly', 'peroxisome organization', 'phosphatidylethanolamine acyl-chain remodeling', 'phospholipid biosynthetic process', 'phospholipid metabolic process', 'regulation of adipose tissue development', 'response to bacterium', 'triglyceride metabolic process']
Microtubule-associated protein RP/EB family member 1
1411
Microtubule-associated protein RP/EB family member 1
1411
5.0
57
0.35
Q15691Q15691['attachment of mitotic spindle microtubules to kinetochore', 'cell division', 'cell migration', 'establishment of mitotic spindle orientation', 'microtubule bundle formation', 'microtubule polymerization', 'negative regulation of microtubule polymerization', 'non-motile cilium assembly', 'positive regulation of microtubule plus-end binding', 'positive regulation of microtubule polymerization', 'protein localization', 'protein localization to astral microtubule', 'protein localization to centrosome', 'protein localization to microtubule', 'protein localization to microtubule plus-end', 'regulation of microtubule polymerization or depolymerization', 'spindle assembly']['attachment of mitotic spindle microtubules to kinetochore', 'cell division', 'cell migration', 'establishment of mitotic spindle orientation', 'microtubule bundle formation', 'microtubule polymerization', 'negative regulation of microtubule polymerization', 'non-motile cilium assembly', 'positive regulation of microtubule plus-end binding', 'positive regulation of microtubule polymerization', 'protein localization', 'protein localization to astral microtubule', 'protein localization to centrosome', 'protein localization to microtubule', 'protein localization to microtubule plus-end', 'regulation of microtubule polymerization or depolymerization', 'spindle assembly']
Amyloid-beta precursor protein
5
Amyloid-beta precursor protein
5
9.2
34
0.32
P05067P05067['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
C-X-C chemokine receptor type 2
47
C-X-C chemokine receptor type 2
47
2.0
73
0.67
P25025P25025['acute inflammatory response to antigenic stimulus', 'calcium-mediated signaling', 'cell chemotaxis', 'cell surface receptor signaling pathway', 'cellular defense response', 'chemotaxis', 'dendritic cell chemotaxis', 'immune response', 'inflammatory response', 'interleukin-8-mediated signaling pathway', 'metanephric tubule morphogenesis', 'midbrain development', 'negative regulation of neutrophil apoptotic process', 'neutrophil activation', 'neutrophil chemotaxis', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of angiogenesis', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of cell population proliferation', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of neutrophil chemotaxis', 'positive regulation of vascular permeability', 'receptor internalization', 'signal transduction']['acute inflammatory response to antigenic stimulus', 'calcium-mediated signaling', 'cell chemotaxis', 'cell surface receptor signaling pathway', 'cellular defense response', 'chemotaxis', 'dendritic cell chemotaxis', 'immune response', 'inflammatory response', 'interleukin-8-mediated signaling pathway', 'metanephric tubule morphogenesis', 'midbrain development', 'negative regulation of neutrophil apoptotic process', 'neutrophil activation', 'neutrophil chemotaxis', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of angiogenesis', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of cell population proliferation', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of neutrophil chemotaxis', 'positive regulation of vascular permeability', 'receptor internalization', 'signal transduction']
Nitric oxide synthase, brain
331
Nitric oxide synthase, brain
96
3.6
72
0.38
P29476P29476['aging', 'arginine catabolic process', 'behavioral response to cocaine', 'brain development', 'cellular response to epinephrine stimulus', 'cellular response to growth factor stimulus', 'cellular response to mechanical stimulus', 'establishment of protein localization', 'female pregnancy', 'multicellular organismal response to stress', 'muscle contraction', 'negative regulation of apoptotic process', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of cell population proliferation', 'negative regulation of cytosolic calcium ion concentration', 'negative regulation of heart contraction', 'negative regulation of hepatic stellate cell contraction', 'negative regulation of hydrolase activity', 'negative regulation of insulin secretion', 'negative regulation of iron ion transmembrane transport', 'negative regulation of neuron apoptotic process', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of potassium ion transport', 'negative regulation of serotonin uptake', 'negative regulation of vasoconstriction', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'positive regulation of guanylate cyclase activity', 'positive regulation of histone acetylation', 'positive regulation of long-term synaptic potentiation', 'positive regulation of neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of sodium ion transmembrane transport', 'positive regulation of the force of heart contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of heart contraction', 'regulation of neurogenesis', 'regulation of sensory perception of pain', 'regulation of sodium ion transport', 'response to activity', 'response to estrogen', 'response to ethanol', 'response to heat', 'response to hormone', 'response to hypoxia', 'response to lead ion', 'response to lipopolysaccharide', 'response to nicotine', 'response to nitric oxide', 'response to nutrient levels', 'response to organic cyclic compound', 'response to organonitrogen compound', 'response to peptide hormone', 'response to vitamin E', 'retrograde trans-synaptic signaling by nitric oxide', 'striated muscle contraction', 'synaptic signaling by nitric oxide', 'vasodilation', 'xenobiotic catabolic process']['aging', 'arginine catabolic process', 'behavioral response to cocaine', 'brain development', 'cellular response to epinephrine stimulus', 'cellular response to growth factor stimulus', 'cellular response to mechanical stimulus', 'establishment of protein localization', 'female pregnancy', 'multicellular organismal response to stress', 'muscle contraction', 'negative regulation of apoptotic process', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of cell population proliferation', 'negative regulation of cytosolic calcium ion concentration', 'negative regulation of heart contraction', 'negative regulation of hepatic stellate cell contraction', 'negative regulation of hydrolase activity', 'negative regulation of insulin secretion', 'negative regulation of iron ion transmembrane transport', 'negative regulation of neuron apoptotic process', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of potassium ion transport', 'negative regulation of serotonin uptake', 'negative regulation of vasoconstriction', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'positive regulation of guanylate cyclase activity', 'positive regulation of histone acetylation', 'positive regulation of long-term synaptic potentiation', 'positive regulation of neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of sodium ion transmembrane transport', 'positive regulation of the force of heart contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of heart contraction', 'regulation of neurogenesis', 'regulation of sensory perception of pain', 'regulation of sodium ion transport', 'response to activity', 'response to estrogen', 'response to ethanol', 'response to heat', 'response to hormone', 'response to hypoxia', 'response to lead ion', 'response to lipopolysaccharide', 'response to nicotine', 'response to nitric oxide', 'response to nutrient levels', 'response to organic cyclic compound', 'response to organonitrogen compound', 'response to peptide hormone', 'response to vitamin E', 'retrograde trans-synaptic signaling by nitric oxide', 'striated muscle contraction', 'synaptic signaling by nitric oxide', 'vasodilation', 'xenobiotic catabolic process']
TRA@ protein
166
Human nkt tcr beta chain
176
2.1
70
0.69
Q2YD82K7N5M4[][]
T cell receptor alpha chain constant
163
Human nkt tcr beta chain
176
2.0
76
0.64
P01848K7N5M4['adaptive immune response', 'alpha-beta T cell activation', 'response to bacterium', 'T cell receptor signaling pathway'][]
SUMO-activating enzyme subunit 2
173
Small ubiquitin-related modifier 1
95
9.3
75
0.14
Q9UBT2P63165['positive regulation of protein sumoylation', 'protein modification by small protein conjugation', 'protein sumoylation']['cellular response to cadmium ion', 'cellular response to heat', 'DNA repair', 'negative regulation of action potential', 'negative regulation of delayed rectifier potassium channel activity', 'negative regulation of DNA binding', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of protein import into nucleus', 'negative regulation of transcription by transcription factor localization', 'negative regulation of transcription, DNA-templated', 'PML body organization', 'positive regulation of ATPase-coupled calcium transmembrane transporter activity', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of protein-containing complex assembly', 'protein localization to nuclear pore', 'protein stabilization', 'protein sumoylation', 'regulation of cardiac muscle cell contraction', 'regulation of protein localization', 'roof of mouth development']
Insulin
6
Insulin
31
8.6
nan
nan
P01308P01308['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']
Collagen alpha-1(III) chain
1196
Collagen alpha-1(III) chain
1196
7.5
nan
nan
P02461P02461['aorta smooth muscle tissue morphogenesis', 'basement membrane organization', 'cell-matrix adhesion', 'cellular response to amino acid stimulus', 'cerebral cortex development', 'chondrocyte differentiation', 'collagen fibril organization', 'digestive tract development', 'elastic fiber assembly', 'endochondral bone morphogenesis', 'extracellular matrix organization', 'fibroblast proliferation', 'heart development', 'in utero embryonic development', 'integrin-mediated signaling pathway', 'layer formation in cerebral cortex', 'limb joint morphogenesis', 'lung development', 'multicellular organism growth', 'negative regulation of immune response', 'negative regulation of neuron migration', 'neuron migration', 'peptide cross-linking', 'platelet activation', 'positive regulation of Rho protein signal transduction', 'response to angiotensin', 'response to cytokine', 'response to radiation', 'skin development', 'supramolecular fiber organization', 'tissue homeostasis', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta1 production', 'wound healing']['aorta smooth muscle tissue morphogenesis', 'basement membrane organization', 'cell-matrix adhesion', 'cellular response to amino acid stimulus', 'cerebral cortex development', 'chondrocyte differentiation', 'collagen fibril organization', 'digestive tract development', 'elastic fiber assembly', 'endochondral bone morphogenesis', 'extracellular matrix organization', 'fibroblast proliferation', 'heart development', 'in utero embryonic development', 'integrin-mediated signaling pathway', 'layer formation in cerebral cortex', 'limb joint morphogenesis', 'lung development', 'multicellular organism growth', 'negative regulation of immune response', 'negative regulation of neuron migration', 'neuron migration', 'peptide cross-linking', 'platelet activation', 'positive regulation of Rho protein signal transduction', 'response to angiotensin', 'response to cytokine', 'response to radiation', 'skin development', 'supramolecular fiber organization', 'tissue homeostasis', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta1 production', 'wound healing']
Collagen alpha-1(III) chain
1196
Collagen alpha-1(III) chain
1464
2.0
nan
nan
P02461P02461['aorta smooth muscle tissue morphogenesis', 'basement membrane organization', 'cell-matrix adhesion', 'cellular response to amino acid stimulus', 'cerebral cortex development', 'chondrocyte differentiation', 'collagen fibril organization', 'digestive tract development', 'elastic fiber assembly', 'endochondral bone morphogenesis', 'extracellular matrix organization', 'fibroblast proliferation', 'heart development', 'in utero embryonic development', 'integrin-mediated signaling pathway', 'layer formation in cerebral cortex', 'limb joint morphogenesis', 'lung development', 'multicellular organism growth', 'negative regulation of immune response', 'negative regulation of neuron migration', 'neuron migration', 'peptide cross-linking', 'platelet activation', 'positive regulation of Rho protein signal transduction', 'response to angiotensin', 'response to cytokine', 'response to radiation', 'skin development', 'supramolecular fiber organization', 'tissue homeostasis', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta1 production', 'wound healing']['aorta smooth muscle tissue morphogenesis', 'basement membrane organization', 'cell-matrix adhesion', 'cellular response to amino acid stimulus', 'cerebral cortex development', 'chondrocyte differentiation', 'collagen fibril organization', 'digestive tract development', 'elastic fiber assembly', 'endochondral bone morphogenesis', 'extracellular matrix organization', 'fibroblast proliferation', 'heart development', 'in utero embryonic development', 'integrin-mediated signaling pathway', 'layer formation in cerebral cortex', 'limb joint morphogenesis', 'lung development', 'multicellular organism growth', 'negative regulation of immune response', 'negative regulation of neuron migration', 'neuron migration', 'peptide cross-linking', 'platelet activation', 'positive regulation of Rho protein signal transduction', 'response to angiotensin', 'response to cytokine', 'response to radiation', 'skin development', 'supramolecular fiber organization', 'tissue homeostasis', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta1 production', 'wound healing']
Laminin subunit alpha-5
529
Laminin subunit gamma-1
852
2.1
69
0.68
O15230P11047['animal organ morphogenesis', 'axon guidance', 'branching involved in salivary gland morphogenesis', 'branching involved in ureteric bud morphogenesis', 'cell migration', 'cell-cell adhesion', 'cilium assembly', 'hair follicle development', 'integrin-mediated signaling pathway', 'lung development', 'morphogenesis of a polarized epithelium', 'morphogenesis of embryonic epithelium', 'muscle organ development', 'odontogenesis of dentin-containing tooth', 'protein localization to plasma membrane', 'regulation of cell adhesion', 'regulation of cell migration', 'regulation of embryonic development', 'regulation of epithelial cell proliferation', 'substrate adhesion-dependent cell spreading', 'tissue development', 'trunk neural crest cell migration']['animal organ morphogenesis', 'cell adhesion', 'cell migration', 'endoderm development', 'extracellular matrix disassembly', 'hemidesmosome assembly', 'maintenance of blood-brain barrier', 'positive regulation of cell adhesion', 'positive regulation of epithelial cell proliferation', 'positive regulation of integrin-mediated signaling pathway', 'positive regulation of muscle cell differentiation', 'protein-containing complex assembly', 'regulation of basement membrane organization', 'substrate adhesion-dependent cell spreading', 'tissue development']
Integrin alpha-X
920
Integrin beta-2
695
8.4
57
0.21
P20702P05107['animal organ morphogenesis', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell-cell adhesion', 'cell-matrix adhesion', 'defense response to virus', 'heterotypic cell-cell adhesion', 'integrin-mediated signaling pathway', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of endothelial tube morphogenesis', 'positive regulation of gene expression', 'positive regulation of myelination']['amyloid-beta clearance', 'apoptotic process', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-cell adhesion', 'cell-cell adhesion via plasma-membrane adhesion molecules', 'cell-cell signaling', 'cell-matrix adhesion', 'cellular response to low-density lipoprotein particle stimulus', 'endodermal cell differentiation', 'heterotypic cell-cell adhesion', 'inflammatory response', 'integrin-mediated signaling pathway', 'leukocyte cell-cell adhesion', 'microglial cell activation', 'negative regulation of dopamine metabolic process', 'neutrophil chemotaxis', 'neutrophil migration', 'phagocytosis, engulfment', 'positive regulation of leukocyte adhesion to vascular endothelial cell', 'positive regulation of neuron death', 'positive regulation of neutrophil degranulation', 'positive regulation of prostaglandin-E synthase activity', 'positive regulation of protein targeting to membrane', 'positive regulation of superoxide anion generation', 'receptor clustering', 'receptor internalization', 'receptor-mediated endocytosis', 'regulation of cell shape', 'regulation of peptidyl-tyrosine phosphorylation']
Integrin alpha-IIb
959
Integrin beta-3
713
9.4
nan
nan
Q17R67P05106['angiogenesis', 'cell adhesion mediated by integrin', 'cell-cell adhesion', 'cell-matrix adhesion', 'integrin-mediated signaling pathway']['activation of protein kinase activity', 'angiogenesis involved in wound healing', 'apolipoprotein A-I-mediated signaling pathway', 'apoptotic cell clearance', 'blood coagulation', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-matrix adhesion', 'cell-substrate adhesion', 'cell-substrate junction assembly', 'cellular response to insulin-like growth factor stimulus', 'cellular response to mechanical stimulus', 'cellular response to platelet-derived growth factor stimulus', 'cellular response to xenobiotic stimulus', 'embryo implantation', 'heterotypic cell-cell adhesion', 'integrin-mediated signaling pathway', 'mesodermal cell differentiation', 'negative chemotaxis', 'negative regulation of cell death', 'negative regulation of lipid storage', 'negative regulation of lipid transport', 'negative regulation of lipoprotein metabolic process', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of macrophage derived foam cell differentiation', 'platelet activation', 'platelet aggregation', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway', 'positive regulation of angiogenesis', 'positive regulation of bone resorption', 'positive regulation of cell adhesion mediated by integrin', 'positive regulation of cell-matrix adhesion', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of osteoblast proliferation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein phosphorylation', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of T cell migration', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of actin cytoskeleton organization', 'regulation of bone resorption', 'regulation of extracellular matrix organization', 'regulation of postsynaptic neurotransmitter receptor internalization', 'regulation of protein localization', 'regulation of protein tyrosine kinase activity', 'regulation of release of sequestered calcium ion into cytosol', 'regulation of serotonin uptake', 'regulation of trophoblast cell migration', 'response to activity', 'response to radiation', 'smooth muscle cell migration', 'substrate adhesion-dependent cell spreading', 'tube development', 'viral entry into host cell', 'wound healing']
Protein phosphatase 3 catalytic subunit alpha
336
Calcipressin-1
216
2.0
nan
nan
Q08209P53805['aging', 'brain development', 'calcineurin-mediated signaling', 'calcineurin-NFAT signaling cascade', 'calcium ion transport', 'cardiac muscle hypertrophy in response to stress', 'cellular response to glucose stimulus', 'dendrite morphogenesis', 'dephosphorylation', 'epidermis development', 'excitatory postsynaptic potential', 'G1/S transition of mitotic cell cycle', 'keratinocyte differentiation', 'modulation of chemical synaptic transmission', 'multicellular organismal response to stress', 'negative regulation of calcium ion import across plasma membrane', 'negative regulation of chromatin binding', 'negative regulation of dendrite morphogenesis', 'negative regulation of insulin secretion', 'negative regulation of miRNA maturation', 'negative regulation of signaling', 'negative regulation of voltage-gated calcium channel activity', 'peptidyl-serine dephosphorylation', 'positive regulation of activated T cell proliferation', 'positive regulation of calcineurin-NFAT signaling cascade', 'positive regulation of calcium ion import across plasma membrane', 'positive regulation of cardiac muscle hypertrophy in response to stress', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of connective tissue replacement', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endocytosis', 'positive regulation of glomerulus development', 'positive regulation of osteoblast differentiation', 'positive regulation of osteoclast differentiation', 'positive regulation of saliva secretion', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of voltage-gated calcium channel activity', 'postsynaptic modulation of chemical synaptic transmission', 'protein dephosphorylation', 'protein import into nucleus', 'regulation of cell proliferation involved in kidney morphogenesis', 'renal filtration', 'response to amphetamine', 'response to calcium ion', 'skeletal muscle fiber development', 'skeletal muscle tissue regeneration', 'T cell activation', 'transition between fast and slow fiber', 'wound healing']['calcineurin-NFAT signaling cascade', 'calcium-mediated signaling', 'locomotion involved in locomotory behavior', 'negative regulation of calcineurin-NFAT signaling cascade', 'regulation of phosphoprotein phosphatase activity', 'response to ischemia', 'response to oxidative stress', 'short-term memory', 'skeletal muscle fiber development']
CCAAT/enhancer-binding protein alpha
245
CCAAT/enhancer-binding protein alpha
56
7.5
56
0.24
P49715P49715['brown fat cell differentiation', 'cellular response to lithium ion', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'cholesterol metabolic process', 'cytokine-mediated signaling pathway', 'embryonic placenta development', 'epithelial cell maturation', 'fat cell differentiation', 'generation of precursor metabolites and energy', 'glucose homeostasis', 'granulocyte differentiation', 'hematopoietic stem cell proliferation', 'inner ear development', 'integrated stress response signaling', 'interleukin-6-mediated signaling pathway', 'lipid homeostasis', 'liver development', 'lung development', 'macrophage differentiation', 'mitochondrion organization', 'myeloid cell differentiation', 'negative regulation of cell population proliferation', 'negative regulation of cyclin-dependent protein serine/threonine kinase activity', 'negative regulation of hematopoietic stem cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'Notch signaling pathway', 'positive regulation of DNA-templated transcription, initiation', 'positive regulation of fat cell differentiation', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of macrophage activation', 'positive regulation of osteoblast differentiation', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase III', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'transcription by RNA polymerase I', 'urea cycle', 'white fat cell differentiation']['brown fat cell differentiation', 'cellular response to lithium ion', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'cholesterol metabolic process', 'cytokine-mediated signaling pathway', 'embryonic placenta development', 'epithelial cell maturation', 'fat cell differentiation', 'generation of precursor metabolites and energy', 'glucose homeostasis', 'granulocyte differentiation', 'hematopoietic stem cell proliferation', 'inner ear development', 'integrated stress response signaling', 'interleukin-6-mediated signaling pathway', 'lipid homeostasis', 'liver development', 'lung development', 'macrophage differentiation', 'mitochondrion organization', 'myeloid cell differentiation', 'negative regulation of cell population proliferation', 'negative regulation of cyclin-dependent protein serine/threonine kinase activity', 'negative regulation of hematopoietic stem cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'Notch signaling pathway', 'positive regulation of DNA-templated transcription, initiation', 'positive regulation of fat cell differentiation', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of macrophage activation', 'positive regulation of osteoblast differentiation', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase III', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'transcription by RNA polymerase I', 'urea cycle', 'white fat cell differentiation']
Insulin
7
Insulin
31
2.0
nan
nan
P01308P01308['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']
Uncharacterized protein DKFZp686I04196
97
Tumor necrosis factor receptor superfamily member 13C
24
5.3
76
0.25
Q6N093Q96RJ3[]['adaptive immune response', 'B cell costimulation', 'positive regulation of B cell proliferation', 'positive regulation of T cell proliferation', 'T cell costimulation', 'tumor necrosis factor-mediated signaling pathway']
Uncharacterized protein DKFZp686I04196
100
Tumor necrosis factor receptor superfamily member 13C
24
5.4
58
0.32
Q6N093Q96RJ3[]['adaptive immune response', 'B cell costimulation', 'positive regulation of B cell proliferation', 'positive regulation of T cell proliferation', 'T cell costimulation', 'tumor necrosis factor-mediated signaling pathway']
Chymotrypsinogen A
1
Chymotrypsinogen A
1
10.0
nan
nan
P00766P00766['digestion', 'proteolysis']['digestion', 'proteolysis']
Killer cell lectin-like receptor subfamily G member 1
75
Killer cell lectin-like receptor subfamily G member 1
75
8.6
nan
nan
O88713O88713['cell surface receptor signaling pathway', 'innate immune response']['cell surface receptor signaling pathway', 'innate immune response']
Uncharacterized protein DKFZp686I04196
97
Tumor necrosis factor receptor superfamily member 13C
35
4.6
72
0.3
Q6N093Q96RJ3[]['adaptive immune response', 'B cell costimulation', 'positive regulation of B cell proliferation', 'positive regulation of T cell proliferation', 'T cell costimulation', 'tumor necrosis factor-mediated signaling pathway']
Complement C3
1010
Complement C3
1010
8.1
nan
nan
P01026P01026['amyloid-beta clearance', 'blood coagulation', 'cell surface receptor signaling pathway involved in cell-cell signaling', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'complement-mediated synapse pruning', 'fatty acid metabolic process', 'inflammatory response', 'neuron remodeling', 'opsonization', 'oviduct epithelium development', 'positive regulation of activation of membrane attack complex', 'positive regulation of angiogenesis', 'positive regulation of apoptotic cell clearance', 'positive regulation of developmental growth', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of glucose transmembrane transport', 'positive regulation of lipid storage', 'positive regulation of opsonization', 'positive regulation of phagocytosis', 'positive regulation of phagocytosis, engulfment', 'positive regulation of protein phosphorylation', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of type IIa hypersensitivity', 'positive regulation of vascular endothelial growth factor production', 'proteolysis', 'regulation of complement activation', 'regulation of complement activation, alternative pathway', 'regulation of triglyceride biosynthetic process', 'response to bacterium', 'response to estradiol', 'response to estrogen', 'response to glucocorticoid', 'response to magnesium ion', 'response to paclitaxel', 'response to progesterone', 'retina development in camera-type eye', 'tolerance induction', 'vascular associated smooth muscle cell differentiation', 'vertebrate eye-specific patterning']['amyloid-beta clearance', 'blood coagulation', 'cell surface receptor signaling pathway involved in cell-cell signaling', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'complement-mediated synapse pruning', 'fatty acid metabolic process', 'inflammatory response', 'neuron remodeling', 'opsonization', 'oviduct epithelium development', 'positive regulation of activation of membrane attack complex', 'positive regulation of angiogenesis', 'positive regulation of apoptotic cell clearance', 'positive regulation of developmental growth', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of glucose transmembrane transport', 'positive regulation of lipid storage', 'positive regulation of opsonization', 'positive regulation of phagocytosis', 'positive regulation of phagocytosis, engulfment', 'positive regulation of protein phosphorylation', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of type IIa hypersensitivity', 'positive regulation of vascular endothelial growth factor production', 'proteolysis', 'regulation of complement activation', 'regulation of complement activation, alternative pathway', 'regulation of triglyceride biosynthetic process', 'response to bacterium', 'response to estradiol', 'response to estrogen', 'response to glucocorticoid', 'response to magnesium ion', 'response to paclitaxel', 'response to progesterone', 'retina development in camera-type eye', 'tolerance induction', 'vascular associated smooth muscle cell differentiation', 'vertebrate eye-specific patterning']
Uncharacterized protein DKFZp686I04196
100
Tumor necrosis factor receptor superfamily member 13C
35
5.4
54
0.34
Q6N093Q96RJ3[]['adaptive immune response', 'B cell costimulation', 'positive regulation of B cell proliferation', 'positive regulation of T cell proliferation', 'T cell costimulation', 'tumor necrosis factor-mediated signaling pathway']
Leukocyte elastase inhibitor
344
Leukocyte elastase inhibitor
344
2.0
35
1.4
P30740P30740['negative regulation of endopeptidase activity', 'negative regulation of interleukin-1 beta production', 'type B pancreatic cell proliferation']['negative regulation of endopeptidase activity', 'negative regulation of interleukin-1 beta production', 'type B pancreatic cell proliferation']
Immunoglobulin heavy constant gamma 1
109
Immunoglobulin heavy constant gamma 1
109
2.0
nan
nan
P01857P01857['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
Egl nine homolog 1
201
Hypoxia-inducible factor 1-alpha
780
2.0
78
0.63
Q9GZT9Q16665['cardiac muscle tissue morphogenesis', 'cellular iron ion homeostasis', 'cellular response to hypoxia', 'heart trabecula formation', 'labyrinthine layer development', 'negative regulation of cyclic-nucleotide phosphodiesterase activity', 'negative regulation of DNA-binding transcription factor activity', 'oxygen homeostasis', 'peptidyl-proline hydroxylation to 4-hydroxy-L-proline', 'positive regulation of transcription by RNA polymerase II', 'regulation of angiogenesis', 'regulation of neuron death', 'regulation of postsynapse organization', 'regulation of protein catabolic process at postsynapse, modulating synaptic transmission', 'response to hypoxia', 'response to nitric oxide', 'ventricular septum morphogenesis']['angiogenesis', 'axonal transport of mitochondrion', 'B-1 B cell homeostasis', 'bone mineralization', 'cardiac ventricle morphogenesis', 'cellular glucose homeostasis', 'cellular iron ion homeostasis', 'cellular response to hypoxia', 'cellular response to interleukin-1', 'cellular response to virus', 'cerebral cortex development', 'chondrocyte differentiation', 'collagen metabolic process', 'connective tissue replacement involved in inflammatory response wound healing', 'digestive tract morphogenesis', 'dopaminergic neuron differentiation', 'elastin metabolic process', 'embryonic hemopoiesis', 'embryonic placenta development', 'epithelial cell differentiation involved in mammary gland alveolus development', 'epithelial to mesenchymal transition', 'glandular epithelial cell maturation', 'heart looping', 'hemoglobin biosynthetic process', 'hypoxia-inducible factor-1alpha signaling pathway', 'insulin secretion involved in cellular response to glucose stimulus', 'intestinal epithelial cell maturation', 'iris morphogenesis', 'lactate metabolic process', 'lactation', 'mesenchymal cell apoptotic process', 'muscle cell cellular homeostasis', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'negative regulation of growth', 'negative regulation of mesenchymal cell apoptotic process', 'negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of thymocyte apoptotic process', 'negative regulation of TOR signaling', 'neural crest cell migration', 'neural fold elevation formation', 'neuroblast proliferation', 'neuron apoptotic process', 'outflow tract morphogenesis', 'oxygen homeostasis', 'positive regulation of angiogenesis', 'positive regulation of autophagy of mitochondrion', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of chemokine production', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of erythrocyte differentiation', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of hormone biosynthetic process', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of macroautophagy', 'positive regulation of miRNA transcription', 'positive regulation of neuroblast proliferation', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of signaling receptor activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of aerobic respiration', 'regulation of gene expression', 'regulation of glycolytic process', 'regulation of protein neddylation', 'regulation of transcription by RNA polymerase II', 'regulation of transcription from RNA polymerase II promoter in response to oxidative stress', 'regulation of transcription, DNA-templated', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to iron ion', 'response to muscle activity', 'response to reactive oxygen species', 'retina vasculature development in camera-type eye', 'signal transduction', 'TOR signaling', 'vascular endothelial growth factor production', 'visual learning']
Potassium channel subfamily K member 2
108
Potassium channel subfamily K member 2
108
2.0
38
1.3
P97438P97438['cardiac ventricle development', 'cellular response to hypoxia', 'cochlea development', 'G protein-coupled receptor signaling pathway', 'memory', 'negative regulation of cardiac muscle cell proliferation', 'negative regulation of DNA biosynthetic process', 'positive regulation of cell death', 'positive regulation of cellular response to hypoxia', 'potassium ion transmembrane transport', 'potassium ion transport', 'regulation of membrane potential', 'response to axon injury', 'response to mechanical stimulus', 'stabilization of membrane potential']['cardiac ventricle development', 'cellular response to hypoxia', 'cochlea development', 'G protein-coupled receptor signaling pathway', 'memory', 'negative regulation of cardiac muscle cell proliferation', 'negative regulation of DNA biosynthetic process', 'positive regulation of cell death', 'positive regulation of cellular response to hypoxia', 'potassium ion transmembrane transport', 'potassium ion transport', 'regulation of membrane potential', 'response to axon injury', 'response to mechanical stimulus', 'stabilization of membrane potential']
Glutamate receptor ionotropic, NMDA 1
810
Glutamate receptor ionotropic, NMDA 2B
321
2.0
45
1.09
P35439Q00960['adult locomotory behavior', 'associative learning', 'calcium ion homeostasis', 'calcium ion transmembrane import into cytosol', 'calcium ion transport', 'cation transmembrane transport', 'cation transport', 'cellular calcium ion homeostasis', 'cellular response to manganese ion', 'cerebral cortex development', 'chemical synaptic transmission', 'conditioned taste aversion', 'excitatory postsynaptic potential', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'long-term memory', 'male mating behavior', 'memory', 'negative regulation of neuron apoptotic process', 'neuromuscular process', 'olfactory learning', 'pons maturation', 'positive regulation of apoptotic process', 'positive regulation of calcium ion transport into cytosol', 'positive regulation of cell death', 'positive regulation of cysteine-type endopeptidase activity', 'positive regulation of dendritic spine maintenance', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of reactive oxygen species biosynthetic process', 'positive regulation of Schwann cell migration', 'positive regulation of synaptic transmission, glutamatergic', 'positive regulation of transcription by RNA polymerase II', 'prepulse inhibition', 'propylene metabolic process', 'protein heterotetramerization', 'protein localization to postsynaptic membrane', 'protein-containing complex assembly', 'regulation of axonogenesis', 'regulation of cation transmembrane transport', 'regulation of cell communication', 'regulation of dendrite morphogenesis', 'regulation of long-term neuronal synaptic plasticity', 'regulation of membrane potential', 'regulation of neuron apoptotic process', 'regulation of neuronal synaptic plasticity', 'regulation of respiratory gaseous exchange', 'regulation of synapse assembly', 'regulation of synaptic plasticity', 'response to amine', 'response to amphetamine', 'response to calcium ion', 'response to ethanol', 'response to fungicide', 'response to glycine', 'response to morphine', 'response to organic cyclic compound', 'rhythmic process', 'sensory perception of pain', 'social behavior', 'startle response', 'suckling behavior', 'synaptic transmission, glutamatergic', 'visual learning']['action potential', 'associative learning', 'behavioral fear response', 'behavioral response to pain', 'calcium ion transmembrane import into cytosol', 'calcium ion transport', 'cation transmembrane transport', 'cation transport', 'cellular response to amino acid stimulus', 'cellular response to corticosterone stimulus', 'cellular response to curcumin', 'cellular response to dsRNA', 'cellular response to forskolin', 'cellular response to growth factor stimulus', 'cellular response to lipid', 'cellular response to magnesium starvation', 'cellular response to manganese ion', 'cellular response to organic cyclic compound', 'cerebral cortex development', 'chemical synaptic transmission', 'detection of mechanical stimulus involved in sensory perception of pain', 'excitatory postsynaptic potential', 'fear response', 'hippocampus development', 'in utero embryonic development', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'long-term memory', 'long-term synaptic potentiation', 'memory', 'multicellular organismal response to stress', 'negative regulation of dendritic spine maintenance', 'NMDA selective glutamate receptor signaling pathway', 'positive regulation of cell death', 'positive regulation of cysteine-type endopeptidase activity', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of glutamate secretion', 'positive regulation of neuron death', 'positive regulation of synaptic transmission', 'positive regulation of synaptic transmission, glutamatergic', 'protein heterotetramerization', 'receptor clustering', 'regulation of cation transmembrane transport', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of neuronal synaptic plasticity', 'regulation of postsynaptic cytosolic calcium ion concentration', 'regulation of postsynaptic membrane potential', 'regulation of protein kinase A signaling', 'regulation of synaptic plasticity', 'response to amine', 'response to amphetamine', 'response to calcium ion', 'response to carbohydrate', 'response to cocaine', 'response to cytokine', 'response to electrical stimulus', 'response to ethanol', 'response to fungicide', 'response to growth hormone', 'response to hypoxia', 'response to magnesium ion', 'response to manganese ion', 'response to mechanical stimulus', 'response to methylmercury', 'response to organic cyclic compound', 'response to organonitrogen compound', 'response to other organism', 'response to toxic substance', 'rhythmic process', 'sensitization', 'sensory organ development', 'startle response', 'suckling behavior']
Immunoglobulin heavy constant gamma 1
349
Immunoglobulin heavy constant gamma 1
112
2.1
70
0.69
P01857P01857['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
Integrin alpha-V
400
Integrin beta-6
604
2.0
64
0.77
P06756P18564['angiogenesis', 'apolipoprotein A-I-mediated signaling pathway', 'apoptotic cell clearance', 'calcium ion transmembrane transport', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-cell adhesion', 'cell-matrix adhesion', 'cell-substrate adhesion', 'endodermal cell differentiation', 'entry into host cell by a symbiont-containing vacuole', 'ERK1 and ERK2 cascade', 'extrinsic apoptotic signaling pathway in absence of ligand', 'heterotypic cell-cell adhesion', 'integrin-mediated signaling pathway', 'negative chemotaxis', 'negative regulation of entry of bacterium into host cell', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of lipid storage', 'negative regulation of lipid transport', 'negative regulation of lipoprotein metabolic process', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of macrophage derived foam cell differentiation', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of intracellular signal transduction', 'positive regulation of osteoblast proliferation', 'positive regulation of small GTPase mediated signal transduction', 'regulation of phagocytosis', 'regulation of transforming growth factor beta activation', 'substrate adhesion-dependent cell spreading', 'transforming growth factor beta production', 'vasculogenesis', 'viral entry into host cell']['bone development', 'bronchiole development', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell morphogenesis', 'cell-matrix adhesion', 'cellular response to ionizing radiation', 'enamel mineralization', 'hard palate development', 'immune response', 'inflammatory response', 'integrin-mediated signaling pathway', 'Langerhans cell differentiation', 'lung alveolus development', 'phospholipid homeostasis', 'regulation of transforming growth factor beta activation', 'response to virus', 'skin development', 'SMAD protein signal transduction', 'surfactant homeostasis', 'transforming growth factor beta production', 'transforming growth factor beta receptor signaling pathway', 'wound healing']
Integrin alpha-V
401
Integrin beta-8
601
2.0
65
0.76
P06756P26012['angiogenesis', 'apolipoprotein A-I-mediated signaling pathway', 'apoptotic cell clearance', 'calcium ion transmembrane transport', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-cell adhesion', 'cell-matrix adhesion', 'cell-substrate adhesion', 'endodermal cell differentiation', 'entry into host cell by a symbiont-containing vacuole', 'ERK1 and ERK2 cascade', 'extrinsic apoptotic signaling pathway in absence of ligand', 'heterotypic cell-cell adhesion', 'integrin-mediated signaling pathway', 'negative chemotaxis', 'negative regulation of entry of bacterium into host cell', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of lipid storage', 'negative regulation of lipid transport', 'negative regulation of lipoprotein metabolic process', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of macrophage derived foam cell differentiation', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of intracellular signal transduction', 'positive regulation of osteoblast proliferation', 'positive regulation of small GTPase mediated signal transduction', 'regulation of phagocytosis', 'regulation of transforming growth factor beta activation', 'substrate adhesion-dependent cell spreading', 'transforming growth factor beta production', 'vasculogenesis', 'viral entry into host cell']['cartilage development', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-matrix adhesion', 'ganglioside metabolic process', 'hard palate development', 'immune response', 'integrin-mediated signaling pathway', 'Langerhans cell differentiation', 'negative regulation of gene expression', 'placenta blood vessel development', 'positive regulation of angiogenesis', 'positive regulation of gene expression', 'regulation of transforming growth factor beta activation', 'response to virus', 'transforming growth factor beta receptor signaling pathway', 'vasculogenesis']
Integrin alpha-V
401
Integrin beta-6
604
2.0
65
0.76
P06756P18564['angiogenesis', 'apolipoprotein A-I-mediated signaling pathway', 'apoptotic cell clearance', 'calcium ion transmembrane transport', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-cell adhesion', 'cell-matrix adhesion', 'cell-substrate adhesion', 'endodermal cell differentiation', 'entry into host cell by a symbiont-containing vacuole', 'ERK1 and ERK2 cascade', 'extrinsic apoptotic signaling pathway in absence of ligand', 'heterotypic cell-cell adhesion', 'integrin-mediated signaling pathway', 'negative chemotaxis', 'negative regulation of entry of bacterium into host cell', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of lipid storage', 'negative regulation of lipid transport', 'negative regulation of lipoprotein metabolic process', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of macrophage derived foam cell differentiation', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of intracellular signal transduction', 'positive regulation of osteoblast proliferation', 'positive regulation of small GTPase mediated signal transduction', 'regulation of phagocytosis', 'regulation of transforming growth factor beta activation', 'substrate adhesion-dependent cell spreading', 'transforming growth factor beta production', 'vasculogenesis', 'viral entry into host cell']['bone development', 'bronchiole development', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell morphogenesis', 'cell-matrix adhesion', 'cellular response to ionizing radiation', 'enamel mineralization', 'hard palate development', 'immune response', 'inflammatory response', 'integrin-mediated signaling pathway', 'Langerhans cell differentiation', 'lung alveolus development', 'phospholipid homeostasis', 'regulation of transforming growth factor beta activation', 'response to virus', 'skin development', 'SMAD protein signal transduction', 'surfactant homeostasis', 'transforming growth factor beta production', 'transforming growth factor beta receptor signaling pathway', 'wound healing']
Egl nine homolog 1
317
Hypoxia-inducible factor 1-alpha
780
2.0
54
0.91
Q9GZT9Q16665['cardiac muscle tissue morphogenesis', 'cellular iron ion homeostasis', 'cellular response to hypoxia', 'heart trabecula formation', 'labyrinthine layer development', 'negative regulation of cyclic-nucleotide phosphodiesterase activity', 'negative regulation of DNA-binding transcription factor activity', 'oxygen homeostasis', 'peptidyl-proline hydroxylation to 4-hydroxy-L-proline', 'positive regulation of transcription by RNA polymerase II', 'regulation of angiogenesis', 'regulation of neuron death', 'regulation of postsynapse organization', 'regulation of protein catabolic process at postsynapse, modulating synaptic transmission', 'response to hypoxia', 'response to nitric oxide', 'ventricular septum morphogenesis']['angiogenesis', 'axonal transport of mitochondrion', 'B-1 B cell homeostasis', 'bone mineralization', 'cardiac ventricle morphogenesis', 'cellular glucose homeostasis', 'cellular iron ion homeostasis', 'cellular response to hypoxia', 'cellular response to interleukin-1', 'cellular response to virus', 'cerebral cortex development', 'chondrocyte differentiation', 'collagen metabolic process', 'connective tissue replacement involved in inflammatory response wound healing', 'digestive tract morphogenesis', 'dopaminergic neuron differentiation', 'elastin metabolic process', 'embryonic hemopoiesis', 'embryonic placenta development', 'epithelial cell differentiation involved in mammary gland alveolus development', 'epithelial to mesenchymal transition', 'glandular epithelial cell maturation', 'heart looping', 'hemoglobin biosynthetic process', 'hypoxia-inducible factor-1alpha signaling pathway', 'insulin secretion involved in cellular response to glucose stimulus', 'intestinal epithelial cell maturation', 'iris morphogenesis', 'lactate metabolic process', 'lactation', 'mesenchymal cell apoptotic process', 'muscle cell cellular homeostasis', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'negative regulation of growth', 'negative regulation of mesenchymal cell apoptotic process', 'negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of thymocyte apoptotic process', 'negative regulation of TOR signaling', 'neural crest cell migration', 'neural fold elevation formation', 'neuroblast proliferation', 'neuron apoptotic process', 'outflow tract morphogenesis', 'oxygen homeostasis', 'positive regulation of angiogenesis', 'positive regulation of autophagy of mitochondrion', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of chemokine production', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of erythrocyte differentiation', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of hormone biosynthetic process', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of macroautophagy', 'positive regulation of miRNA transcription', 'positive regulation of neuroblast proliferation', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of signaling receptor activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of aerobic respiration', 'regulation of gene expression', 'regulation of glycolytic process', 'regulation of protein neddylation', 'regulation of transcription by RNA polymerase II', 'regulation of transcription from RNA polymerase II promoter in response to oxidative stress', 'regulation of transcription, DNA-templated', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to iron ion', 'response to muscle activity', 'response to reactive oxygen species', 'retina vasculature development in camera-type eye', 'signal transduction', 'TOR signaling', 'vascular endothelial growth factor production', 'visual learning']
Integrin alpha-V
969
Integrin beta-3
643
2.0
nan
nan
P06756P05106['angiogenesis', 'apolipoprotein A-I-mediated signaling pathway', 'apoptotic cell clearance', 'calcium ion transmembrane transport', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-cell adhesion', 'cell-matrix adhesion', 'cell-substrate adhesion', 'endodermal cell differentiation', 'entry into host cell by a symbiont-containing vacuole', 'ERK1 and ERK2 cascade', 'extrinsic apoptotic signaling pathway in absence of ligand', 'heterotypic cell-cell adhesion', 'integrin-mediated signaling pathway', 'negative chemotaxis', 'negative regulation of entry of bacterium into host cell', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of lipid storage', 'negative regulation of lipid transport', 'negative regulation of lipoprotein metabolic process', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of macrophage derived foam cell differentiation', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of intracellular signal transduction', 'positive regulation of osteoblast proliferation', 'positive regulation of small GTPase mediated signal transduction', 'regulation of phagocytosis', 'regulation of transforming growth factor beta activation', 'substrate adhesion-dependent cell spreading', 'transforming growth factor beta production', 'vasculogenesis', 'viral entry into host cell']['activation of protein kinase activity', 'angiogenesis involved in wound healing', 'apolipoprotein A-I-mediated signaling pathway', 'apoptotic cell clearance', 'blood coagulation', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-matrix adhesion', 'cell-substrate adhesion', 'cell-substrate junction assembly', 'cellular response to insulin-like growth factor stimulus', 'cellular response to mechanical stimulus', 'cellular response to platelet-derived growth factor stimulus', 'cellular response to xenobiotic stimulus', 'embryo implantation', 'heterotypic cell-cell adhesion', 'integrin-mediated signaling pathway', 'mesodermal cell differentiation', 'negative chemotaxis', 'negative regulation of cell death', 'negative regulation of lipid storage', 'negative regulation of lipid transport', 'negative regulation of lipoprotein metabolic process', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of macrophage derived foam cell differentiation', 'platelet activation', 'platelet aggregation', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway', 'positive regulation of angiogenesis', 'positive regulation of bone resorption', 'positive regulation of cell adhesion mediated by integrin', 'positive regulation of cell-matrix adhesion', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of osteoblast proliferation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein phosphorylation', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of T cell migration', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of actin cytoskeleton organization', 'regulation of bone resorption', 'regulation of extracellular matrix organization', 'regulation of postsynaptic neurotransmitter receptor internalization', 'regulation of protein localization', 'regulation of protein tyrosine kinase activity', 'regulation of release of sequestered calcium ion into cytosol', 'regulation of serotonin uptake', 'regulation of trophoblast cell migration', 'response to activity', 'response to radiation', 'smooth muscle cell migration', 'substrate adhesion-dependent cell spreading', 'tube development', 'viral entry into host cell', 'wound healing']
Ribonuclease pancreatic
32
Ribonuclease pancreatic
32
7.0
57
0.25
P07998P07998['defense response to Gram-positive bacterium', 'RNA phosphodiester bond hydrolysis']['defense response to Gram-positive bacterium', 'RNA phosphodiester bond hydrolysis']
Gamma-aminobutyric acid receptor subunit alpha-3
377
Gamma-aminobutyric acid receptor subunit alpha-3
377
5.1
nan
nan
P20236P20236['chemical synaptic transmission', 'chloride transmembrane transport', 'gamma-aminobutyric acid signaling pathway', 'ion transmembrane transport', 'nervous system process', 'regulation of membrane potential', 'regulation of postsynaptic membrane potential', 'signal transduction', 'synaptic transmission, GABAergic']['chemical synaptic transmission', 'chloride transmembrane transport', 'gamma-aminobutyric acid signaling pathway', 'ion transmembrane transport', 'nervous system process', 'regulation of membrane potential', 'regulation of postsynaptic membrane potential', 'signal transduction', 'synaptic transmission, GABAergic']
Ribosomal oxygenase 1
300
60S ribosomal protein L8
214
4.1
55
0.44
Q9H6W3P62917['chromatin organization', 'histone H3-K36 demethylation', 'histone H3-K4 demethylation', 'negative regulation of osteoblast differentiation', 'negative regulation of transcription, DNA-templated']['cytoplasmic translation', 'translation']
Integrin alpha-IIb
959
Integrin beta-3
688
2.0
nan
nan
Q17R67P05106['angiogenesis', 'cell adhesion mediated by integrin', 'cell-cell adhesion', 'cell-matrix adhesion', 'integrin-mediated signaling pathway']['activation of protein kinase activity', 'angiogenesis involved in wound healing', 'apolipoprotein A-I-mediated signaling pathway', 'apoptotic cell clearance', 'blood coagulation', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-matrix adhesion', 'cell-substrate adhesion', 'cell-substrate junction assembly', 'cellular response to insulin-like growth factor stimulus', 'cellular response to mechanical stimulus', 'cellular response to platelet-derived growth factor stimulus', 'cellular response to xenobiotic stimulus', 'embryo implantation', 'heterotypic cell-cell adhesion', 'integrin-mediated signaling pathway', 'mesodermal cell differentiation', 'negative chemotaxis', 'negative regulation of cell death', 'negative regulation of lipid storage', 'negative regulation of lipid transport', 'negative regulation of lipoprotein metabolic process', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of macrophage derived foam cell differentiation', 'platelet activation', 'platelet aggregation', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway', 'positive regulation of angiogenesis', 'positive regulation of bone resorption', 'positive regulation of cell adhesion mediated by integrin', 'positive regulation of cell-matrix adhesion', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of osteoblast proliferation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein phosphorylation', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of T cell migration', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of actin cytoskeleton organization', 'regulation of bone resorption', 'regulation of extracellular matrix organization', 'regulation of postsynaptic neurotransmitter receptor internalization', 'regulation of protein localization', 'regulation of protein tyrosine kinase activity', 'regulation of release of sequestered calcium ion into cytosol', 'regulation of serotonin uptake', 'regulation of trophoblast cell migration', 'response to activity', 'response to radiation', 'smooth muscle cell migration', 'substrate adhesion-dependent cell spreading', 'tube development', 'viral entry into host cell', 'wound healing']
Transcriptional regulator ATRX
200
Transcriptional regulator ATRX
232
4.7
nan
nan
P46100P46100['cellular response to hydroxyurea', 'chromatin remodeling', 'chromosome organization involved in meiotic cell cycle', 'DNA damage response, signal transduction by p53 class mediator', 'DNA methylation', 'DNA repair', 'DNA replication-independent chromatin assembly', 'forebrain development', 'meiotic spindle organization', 'multicellular organism growth', 'negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric', 'negative regulation of telomeric RNA transcription from RNA pol II promoter', 'nucleosome assembly', 'positive regulation of nuclear cell cycle DNA replication', 'positive regulation of telomere maintenance', 'positive regulation of telomeric RNA transcription from RNA pol II promoter', 'positive regulation of transcription by RNA polymerase II', 'post-embryonic forelimb morphogenesis', 'protein localization to chromosome, telomeric region', 'regulation of histone H3-K9 trimethylation', 'regulation of transcription, DNA-templated', 'replication fork processing', 'seminiferous tubule development', 'Sertoli cell development', 'spermatogenesis', 'transcription by RNA polymerase II']['cellular response to hydroxyurea', 'chromatin remodeling', 'chromosome organization involved in meiotic cell cycle', 'DNA damage response, signal transduction by p53 class mediator', 'DNA methylation', 'DNA repair', 'DNA replication-independent chromatin assembly', 'forebrain development', 'meiotic spindle organization', 'multicellular organism growth', 'negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric', 'negative regulation of telomeric RNA transcription from RNA pol II promoter', 'nucleosome assembly', 'positive regulation of nuclear cell cycle DNA replication', 'positive regulation of telomere maintenance', 'positive regulation of telomeric RNA transcription from RNA pol II promoter', 'positive regulation of transcription by RNA polymerase II', 'post-embryonic forelimb morphogenesis', 'protein localization to chromosome, telomeric region', 'regulation of histone H3-K9 trimethylation', 'regulation of transcription, DNA-templated', 'replication fork processing', 'seminiferous tubule development', 'Sertoli cell development', 'spermatogenesis', 'transcription by RNA polymerase II']
Mitochondrial Rho GTPase 2
470
Mitochondrial Rho GTPase 2
470
2.0
74
0.66
Q8IXI1Q8IXI1['cellular homeostasis', 'mitochondrial outer membrane permeabilization', 'mitochondrion organization', 'mitochondrion transport along microtubule', 'regulation of mitochondrion organization', 'small GTPase mediated signal transduction']['cellular homeostasis', 'mitochondrial outer membrane permeabilization', 'mitochondrion organization', 'mitochondrion transport along microtubule', 'regulation of mitochondrion organization', 'small GTPase mediated signal transduction']
Kinesin-like protein KIF21A
1421
Kinesin-like protein KIF21A
1421
9.6
71
0.15
Q7Z4S6Q7Z4S6['microtubule-based movement']['microtubule-based movement']
Inhibitor of nuclear factor kappa-B kinase subunit alpha
114
Inhibitor of nuclear factor kappa-B kinase subunit alpha
114
9.2
71
0.15
O15111O15111['anatomical structure morphogenesis', 'cellular response to cadmium ion', 'cellular response to reactive oxygen species', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'I-kappaB kinase/NF-kappaB signaling', 'I-kappaB phosphorylation', 'immune response', 'inflammatory response', 'innate immune response', 'negative regulation of NF-kappaB transcription factor activity', 'NIK/NF-kappaB signaling', 'peptidyl-serine phosphorylation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interferon-alpha production', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein phosphorylation', 'response to virus', 'tumor necrosis factor-mediated signaling pathway']['anatomical structure morphogenesis', 'cellular response to cadmium ion', 'cellular response to reactive oxygen species', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'I-kappaB kinase/NF-kappaB signaling', 'I-kappaB phosphorylation', 'immune response', 'inflammatory response', 'innate immune response', 'negative regulation of NF-kappaB transcription factor activity', 'NIK/NF-kappaB signaling', 'peptidyl-serine phosphorylation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interferon-alpha production', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein phosphorylation', 'response to virus', 'tumor necrosis factor-mediated signaling pathway']
Caspase-3
220
Caspase-3
220
5.7
82
0.21
P42574P42574['anterior neural tube closure', 'apoptotic process', 'apoptotic signaling pathway', 'axonal fasciculation', 'B cell homeostasis', 'cell fate commitment', 'cellular response to DNA damage stimulus', 'cellular response to staurosporine', 'epithelial cell apoptotic process', 'erythrocyte differentiation', 'execution phase of apoptosis', 'fibroblast apoptotic process', 'glial cell apoptotic process', 'heart development', 'hippocampus development', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway in response to osmotic stress', 'keratinocyte differentiation', 'learning or memory', 'leukocyte apoptotic process', 'luteolysis', 'negative regulation of activated T cell proliferation', 'negative regulation of apoptotic process', 'negative regulation of B cell proliferation', 'neuron apoptotic process', 'neuron differentiation', 'neurotrophin TRK receptor signaling pathway', 'platelet formation', 'positive regulation of amyloid-beta formation', 'positive regulation of apoptotic DNA fragmentation', 'positive regulation of apoptotic process', 'positive regulation of neuron apoptotic process', 'protein catabolic process', 'protein processing', 'proteolysis', 'regulation of macroautophagy', 'regulation of protein stability', 'response to amino acid', 'response to antibiotic', 'response to cobalt ion', 'response to estradiol', 'response to glucocorticoid', 'response to glucose', 'response to hydrogen peroxide', 'response to hypoxia', 'response to lipopolysaccharide', 'response to nicotine', 'response to tumor necrosis factor', 'response to UV', 'response to X-ray', 'response to xenobiotic stimulus', 'sensory perception of sound', 'striated muscle cell differentiation', 'T cell homeostasis', 'wound healing']['anterior neural tube closure', 'apoptotic process', 'apoptotic signaling pathway', 'axonal fasciculation', 'B cell homeostasis', 'cell fate commitment', 'cellular response to DNA damage stimulus', 'cellular response to staurosporine', 'epithelial cell apoptotic process', 'erythrocyte differentiation', 'execution phase of apoptosis', 'fibroblast apoptotic process', 'glial cell apoptotic process', 'heart development', 'hippocampus development', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway in response to osmotic stress', 'keratinocyte differentiation', 'learning or memory', 'leukocyte apoptotic process', 'luteolysis', 'negative regulation of activated T cell proliferation', 'negative regulation of apoptotic process', 'negative regulation of B cell proliferation', 'neuron apoptotic process', 'neuron differentiation', 'neurotrophin TRK receptor signaling pathway', 'platelet formation', 'positive regulation of amyloid-beta formation', 'positive regulation of apoptotic DNA fragmentation', 'positive regulation of apoptotic process', 'positive regulation of neuron apoptotic process', 'protein catabolic process', 'protein processing', 'proteolysis', 'regulation of macroautophagy', 'regulation of protein stability', 'response to amino acid', 'response to antibiotic', 'response to cobalt ion', 'response to estradiol', 'response to glucocorticoid', 'response to glucose', 'response to hydrogen peroxide', 'response to hypoxia', 'response to lipopolysaccharide', 'response to nicotine', 'response to tumor necrosis factor', 'response to UV', 'response to X-ray', 'response to xenobiotic stimulus', 'sensory perception of sound', 'striated muscle cell differentiation', 'T cell homeostasis', 'wound healing']
T-cell receptor alpha chain V region PHDS58
213
T-cell receptor beta-1 chain C region
127
6.3
nan
nan
P01738P01852['adaptive immune response']['B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
Transcriptional regulator ATRX
1614
Transcriptional regulator ATRX
1614
4.6
nan
nan
P46100P46100['cellular response to hydroxyurea', 'chromatin remodeling', 'chromosome organization involved in meiotic cell cycle', 'DNA damage response, signal transduction by p53 class mediator', 'DNA methylation', 'DNA repair', 'DNA replication-independent chromatin assembly', 'forebrain development', 'meiotic spindle organization', 'multicellular organism growth', 'negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric', 'negative regulation of telomeric RNA transcription from RNA pol II promoter', 'nucleosome assembly', 'positive regulation of nuclear cell cycle DNA replication', 'positive regulation of telomere maintenance', 'positive regulation of telomeric RNA transcription from RNA pol II promoter', 'positive regulation of transcription by RNA polymerase II', 'post-embryonic forelimb morphogenesis', 'protein localization to chromosome, telomeric region', 'regulation of histone H3-K9 trimethylation', 'regulation of transcription, DNA-templated', 'replication fork processing', 'seminiferous tubule development', 'Sertoli cell development', 'spermatogenesis', 'transcription by RNA polymerase II']['cellular response to hydroxyurea', 'chromatin remodeling', 'chromosome organization involved in meiotic cell cycle', 'DNA damage response, signal transduction by p53 class mediator', 'DNA methylation', 'DNA repair', 'DNA replication-independent chromatin assembly', 'forebrain development', 'meiotic spindle organization', 'multicellular organism growth', 'negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric', 'negative regulation of telomeric RNA transcription from RNA pol II promoter', 'nucleosome assembly', 'positive regulation of nuclear cell cycle DNA replication', 'positive regulation of telomere maintenance', 'positive regulation of telomeric RNA transcription from RNA pol II promoter', 'positive regulation of transcription by RNA polymerase II', 'post-embryonic forelimb morphogenesis', 'protein localization to chromosome, telomeric region', 'regulation of histone H3-K9 trimethylation', 'regulation of transcription, DNA-templated', 'replication fork processing', 'seminiferous tubule development', 'Sertoli cell development', 'spermatogenesis', 'transcription by RNA polymerase II']
H-2 class II histocompatibility antigen, A-D alpha chain
74
Insulin-1
107
3.0
nan
nan
P04228P01325['adaptive immune response', 'antigen processing and presentation', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'antigen processing and presentation of peptide antigen', 'negative regulation of T cell proliferation', 'peptide antigen assembly with MHC class II protein complex', 'positive regulation of T cell activation', 'positive regulation of T cell differentiation']['glucose homeostasis', 'glucose metabolic process', 'glucose transmembrane transport', 'positive regulation of protein secretion', 'response to cAMP', 'response to cytokine', 'response to peptide hormone']
Glutamate receptor ionotropic, NMDA 1
561
Glutamate receptor ionotropic, NMDA 2B
1006
2.0
37
1.33
P35439Q00960['adult locomotory behavior', 'associative learning', 'calcium ion homeostasis', 'calcium ion transmembrane import into cytosol', 'calcium ion transport', 'cation transmembrane transport', 'cation transport', 'cellular calcium ion homeostasis', 'cellular response to manganese ion', 'cerebral cortex development', 'chemical synaptic transmission', 'conditioned taste aversion', 'excitatory postsynaptic potential', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'long-term memory', 'male mating behavior', 'memory', 'negative regulation of neuron apoptotic process', 'neuromuscular process', 'olfactory learning', 'pons maturation', 'positive regulation of apoptotic process', 'positive regulation of calcium ion transport into cytosol', 'positive regulation of cell death', 'positive regulation of cysteine-type endopeptidase activity', 'positive regulation of dendritic spine maintenance', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of reactive oxygen species biosynthetic process', 'positive regulation of Schwann cell migration', 'positive regulation of synaptic transmission, glutamatergic', 'positive regulation of transcription by RNA polymerase II', 'prepulse inhibition', 'propylene metabolic process', 'protein heterotetramerization', 'protein localization to postsynaptic membrane', 'protein-containing complex assembly', 'regulation of axonogenesis', 'regulation of cation transmembrane transport', 'regulation of cell communication', 'regulation of dendrite morphogenesis', 'regulation of long-term neuronal synaptic plasticity', 'regulation of membrane potential', 'regulation of neuron apoptotic process', 'regulation of neuronal synaptic plasticity', 'regulation of respiratory gaseous exchange', 'regulation of synapse assembly', 'regulation of synaptic plasticity', 'response to amine', 'response to amphetamine', 'response to calcium ion', 'response to ethanol', 'response to fungicide', 'response to glycine', 'response to morphine', 'response to organic cyclic compound', 'rhythmic process', 'sensory perception of pain', 'social behavior', 'startle response', 'suckling behavior', 'synaptic transmission, glutamatergic', 'visual learning']['action potential', 'associative learning', 'behavioral fear response', 'behavioral response to pain', 'calcium ion transmembrane import into cytosol', 'calcium ion transport', 'cation transmembrane transport', 'cation transport', 'cellular response to amino acid stimulus', 'cellular response to corticosterone stimulus', 'cellular response to curcumin', 'cellular response to dsRNA', 'cellular response to forskolin', 'cellular response to growth factor stimulus', 'cellular response to lipid', 'cellular response to magnesium starvation', 'cellular response to manganese ion', 'cellular response to organic cyclic compound', 'cerebral cortex development', 'chemical synaptic transmission', 'detection of mechanical stimulus involved in sensory perception of pain', 'excitatory postsynaptic potential', 'fear response', 'hippocampus development', 'in utero embryonic development', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'long-term memory', 'long-term synaptic potentiation', 'memory', 'multicellular organismal response to stress', 'negative regulation of dendritic spine maintenance', 'NMDA selective glutamate receptor signaling pathway', 'positive regulation of cell death', 'positive regulation of cysteine-type endopeptidase activity', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of glutamate secretion', 'positive regulation of neuron death', 'positive regulation of synaptic transmission', 'positive regulation of synaptic transmission, glutamatergic', 'protein heterotetramerization', 'receptor clustering', 'regulation of cation transmembrane transport', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of neuronal synaptic plasticity', 'regulation of postsynaptic cytosolic calcium ion concentration', 'regulation of postsynaptic membrane potential', 'regulation of protein kinase A signaling', 'regulation of synaptic plasticity', 'response to amine', 'response to amphetamine', 'response to calcium ion', 'response to carbohydrate', 'response to cocaine', 'response to cytokine', 'response to electrical stimulus', 'response to ethanol', 'response to fungicide', 'response to growth hormone', 'response to hypoxia', 'response to magnesium ion', 'response to manganese ion', 'response to mechanical stimulus', 'response to methylmercury', 'response to organic cyclic compound', 'response to organonitrogen compound', 'response to other organism', 'response to toxic substance', 'rhythmic process', 'sensitization', 'sensory organ development', 'startle response', 'suckling behavior']
Glutamate receptor 3
312
Glutamate receptor 3
334
9.4
nan
nan
P19492P19492['regulation of receptor recycling', 'response to fungicide', 'response to lithium ion']['regulation of receptor recycling', 'response to fungicide', 'response to lithium ion']
Annexin A2
262
Annexin A2
262
2.7
38
0.98
P07355P07355['angiogenesis', 'collagen fibril organization', 'fibrinolysis', 'membrane raft assembly', 'mRNA transcription by RNA polymerase II', 'negative regulation of low-density lipoprotein particle receptor catabolic process', 'negative regulation of receptor internalization', 'osteoclast development', 'positive regulation of exocytosis', 'positive regulation of low-density lipoprotein particle clearance', 'positive regulation of low-density lipoprotein particle receptor binding', 'positive regulation of low-density lipoprotein receptor activity', 'positive regulation of plasma membrane repair', 'positive regulation of plasminogen activation', 'positive regulation of receptor recycling', 'positive regulation of receptor-mediated endocytosis involved in cholesterol transport', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vacuole organization', 'positive regulation of vesicle fusion', 'regulation of neurogenesis', 'vesicle budding from membrane']['angiogenesis', 'collagen fibril organization', 'fibrinolysis', 'membrane raft assembly', 'mRNA transcription by RNA polymerase II', 'negative regulation of low-density lipoprotein particle receptor catabolic process', 'negative regulation of receptor internalization', 'osteoclast development', 'positive regulation of exocytosis', 'positive regulation of low-density lipoprotein particle clearance', 'positive regulation of low-density lipoprotein particle receptor binding', 'positive regulation of low-density lipoprotein receptor activity', 'positive regulation of plasma membrane repair', 'positive regulation of plasminogen activation', 'positive regulation of receptor recycling', 'positive regulation of receptor-mediated endocytosis involved in cholesterol transport', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vacuole organization', 'positive regulation of vesicle fusion', 'regulation of neurogenesis', 'vesicle budding from membrane']
Bifunctional peptidase and arginyl-hydroxylase JMJD5
308
RCC1 domain-containing protein 1
139
2.0
nan
nan
Q8N371A6NED2['chromatin organization', 'circadian regulation of gene expression', 'G2/M transition of mitotic cell cycle', 'histone H3-K36 demethylation', 'negative regulation of transcription, DNA-templated', 'positive regulation of transcription, DNA-templated', 'protein destabilization', 'proteolysis']['chromatin organization']
Glutamate receptor ionotropic, NMDA 2B
946
Glutamate receptor ionotropic, NMDA 2B
946
2.0
53
0.93
Q00960Q00960['action potential', 'associative learning', 'behavioral fear response', 'behavioral response to pain', 'calcium ion transmembrane import into cytosol', 'calcium ion transport', 'cation transmembrane transport', 'cation transport', 'cellular response to amino acid stimulus', 'cellular response to corticosterone stimulus', 'cellular response to curcumin', 'cellular response to dsRNA', 'cellular response to forskolin', 'cellular response to growth factor stimulus', 'cellular response to lipid', 'cellular response to magnesium starvation', 'cellular response to manganese ion', 'cellular response to organic cyclic compound', 'cerebral cortex development', 'chemical synaptic transmission', 'detection of mechanical stimulus involved in sensory perception of pain', 'excitatory postsynaptic potential', 'fear response', 'hippocampus development', 'in utero embryonic development', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'long-term memory', 'long-term synaptic potentiation', 'memory', 'multicellular organismal response to stress', 'negative regulation of dendritic spine maintenance', 'NMDA selective glutamate receptor signaling pathway', 'positive regulation of cell death', 'positive regulation of cysteine-type endopeptidase activity', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of glutamate secretion', 'positive regulation of neuron death', 'positive regulation of synaptic transmission', 'positive regulation of synaptic transmission, glutamatergic', 'protein heterotetramerization', 'receptor clustering', 'regulation of cation transmembrane transport', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of neuronal synaptic plasticity', 'regulation of postsynaptic cytosolic calcium ion concentration', 'regulation of postsynaptic membrane potential', 'regulation of protein kinase A signaling', 'regulation of synaptic plasticity', 'response to amine', 'response to amphetamine', 'response to calcium ion', 'response to carbohydrate', 'response to cocaine', 'response to cytokine', 'response to electrical stimulus', 'response to ethanol', 'response to fungicide', 'response to growth hormone', 'response to hypoxia', 'response to magnesium ion', 'response to manganese ion', 'response to mechanical stimulus', 'response to methylmercury', 'response to organic cyclic compound', 'response to organonitrogen compound', 'response to other organism', 'response to toxic substance', 'rhythmic process', 'sensitization', 'sensory organ development', 'startle response', 'suckling behavior']['action potential', 'associative learning', 'behavioral fear response', 'behavioral response to pain', 'calcium ion transmembrane import into cytosol', 'calcium ion transport', 'cation transmembrane transport', 'cation transport', 'cellular response to amino acid stimulus', 'cellular response to corticosterone stimulus', 'cellular response to curcumin', 'cellular response to dsRNA', 'cellular response to forskolin', 'cellular response to growth factor stimulus', 'cellular response to lipid', 'cellular response to magnesium starvation', 'cellular response to manganese ion', 'cellular response to organic cyclic compound', 'cerebral cortex development', 'chemical synaptic transmission', 'detection of mechanical stimulus involved in sensory perception of pain', 'excitatory postsynaptic potential', 'fear response', 'hippocampus development', 'in utero embryonic development', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'long-term memory', 'long-term synaptic potentiation', 'memory', 'multicellular organismal response to stress', 'negative regulation of dendritic spine maintenance', 'NMDA selective glutamate receptor signaling pathway', 'positive regulation of cell death', 'positive regulation of cysteine-type endopeptidase activity', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of glutamate secretion', 'positive regulation of neuron death', 'positive regulation of synaptic transmission', 'positive regulation of synaptic transmission, glutamatergic', 'protein heterotetramerization', 'receptor clustering', 'regulation of cation transmembrane transport', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of neuronal synaptic plasticity', 'regulation of postsynaptic cytosolic calcium ion concentration', 'regulation of postsynaptic membrane potential', 'regulation of protein kinase A signaling', 'regulation of synaptic plasticity', 'response to amine', 'response to amphetamine', 'response to calcium ion', 'response to carbohydrate', 'response to cocaine', 'response to cytokine', 'response to electrical stimulus', 'response to ethanol', 'response to fungicide', 'response to growth hormone', 'response to hypoxia', 'response to magnesium ion', 'response to manganese ion', 'response to mechanical stimulus', 'response to methylmercury', 'response to organic cyclic compound', 'response to organonitrogen compound', 'response to other organism', 'response to toxic substance', 'rhythmic process', 'sensitization', 'sensory organ development', 'startle response', 'suckling behavior']
Store-operated calcium entry-associated regulatory factor
320
Store-operated calcium entry-associated regulatory factor
83
9.6
59
0.18
Q96BY9Q96BY9['calcium ion transport', 'regulation of store-operated calcium entry']['calcium ion transport', 'regulation of store-operated calcium entry']
Protein scribble homolog
864
Protein scribble homolog
864
2.0
80
0.62
Q14160Q14160['activation of GTPase activity', 'apoptotic process involved in morphogenesis', 'astrocyte cell migration', 'auditory receptor cell stereocilium organization', 'cell migration', 'cell population proliferation', 'cell-cell adhesion', 'cochlear nucleus development', 'establishment of apical/basal cell polarity', 'establishment of T cell polarity', 'establishment or maintenance of epithelial cell apical/basal polarity', 'mammary gland duct morphogenesis', 'negative regulation of activated T cell proliferation', 'negative regulation of mitotic cell cycle', 'neural tube closure', 'neurotransmitter receptor transport postsynaptic membrane to endosome', 'neurotransmitter receptor transport, endosome to postsynaptic membrane', 'polarized epithelial cell differentiation', 'positive chemotaxis', 'positive regulation of apoptotic process', 'positive regulation of interferon-gamma production', 'positive regulation of receptor recycling', 'post-anal tail morphogenesis', 'protein localization to adherens junction', 'receptor clustering', 'receptor localization to synapse', 'regulation of postsynaptic neurotransmitter receptor internalization', 'synaptic vesicle endocytosis', 'synaptic vesicle targeting', 'wound healing']['activation of GTPase activity', 'apoptotic process involved in morphogenesis', 'astrocyte cell migration', 'auditory receptor cell stereocilium organization', 'cell migration', 'cell population proliferation', 'cell-cell adhesion', 'cochlear nucleus development', 'establishment of apical/basal cell polarity', 'establishment of T cell polarity', 'establishment or maintenance of epithelial cell apical/basal polarity', 'mammary gland duct morphogenesis', 'negative regulation of activated T cell proliferation', 'negative regulation of mitotic cell cycle', 'neural tube closure', 'neurotransmitter receptor transport postsynaptic membrane to endosome', 'neurotransmitter receptor transport, endosome to postsynaptic membrane', 'polarized epithelial cell differentiation', 'positive chemotaxis', 'positive regulation of apoptotic process', 'positive regulation of interferon-gamma production', 'positive regulation of receptor recycling', 'post-anal tail morphogenesis', 'protein localization to adherens junction', 'receptor clustering', 'receptor localization to synapse', 'regulation of postsynaptic neurotransmitter receptor internalization', 'synaptic vesicle endocytosis', 'synaptic vesicle targeting', 'wound healing']
Cartilage oligomeric matrix protein
71
Cartilage oligomeric matrix protein
68
2.0
54
0.91
P35444P35444['apoptotic process', 'artery morphogenesis', 'blood coagulation', 'BMP signaling pathway', 'bone growth', 'bone mineralization', 'bone morphogenesis', 'cartilage development', 'cartilage homeostasis', 'chondrocyte development', 'chondrocyte proliferation', 'collagen fibril organization', 'endochondral bone growth', 'growth plate cartilage development', 'limb development', 'multicellular organism aging', 'multicellular organism growth', 'muscle cell development', 'musculoskeletal movement', 'negative regulation of apoptotic process', 'negative regulation of hemostasis', 'neuromuscular process', 'ossification', 'platelet aggregation', 'positive regulation of chondrocyte proliferation', 'protein homooligomerization', 'protein processing', 'protein secretion', 'regulation of bone mineralization', 'regulation of gene expression', 'response to unfolded protein', 'skeletal system development', 'skin development', 'tendon development', 'vascular associated smooth muscle cell development', 'vascular associated smooth muscle contraction']['apoptotic process', 'artery morphogenesis', 'blood coagulation', 'BMP signaling pathway', 'bone growth', 'bone mineralization', 'bone morphogenesis', 'cartilage development', 'cartilage homeostasis', 'chondrocyte development', 'chondrocyte proliferation', 'collagen fibril organization', 'endochondral bone growth', 'growth plate cartilage development', 'limb development', 'multicellular organism aging', 'multicellular organism growth', 'muscle cell development', 'musculoskeletal movement', 'negative regulation of apoptotic process', 'negative regulation of hemostasis', 'neuromuscular process', 'ossification', 'platelet aggregation', 'positive regulation of chondrocyte proliferation', 'protein homooligomerization', 'protein processing', 'protein secretion', 'regulation of bone mineralization', 'regulation of gene expression', 'response to unfolded protein', 'skeletal system development', 'skin development', 'tendon development', 'vascular associated smooth muscle cell development', 'vascular associated smooth muscle contraction']
Protein kinase C delta type
280
Protein kinase C delta type
247
9.1
nan
nan
A0A140UHX0A0A140UHX0['apoptotic process', 'cell cycle', 'protein phosphorylation']['apoptotic process', 'cell cycle', 'protein phosphorylation']
Hepatocyte growth factor
289
Hepatocyte growth factor
212
8.5
82
0.14
Q08048Q08048['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'proteolysis', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'proteolysis', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']
Neuropilin-1
424
Neuropilin-1
275
9.5
67
0.16
O14786O14786['actin cytoskeleton reorganization', 'angiogenesis', 'angiogenesis involved in coronary vascular morphogenesis', 'animal organ morphogenesis', 'artery morphogenesis', 'axon extension involved in axon guidance', 'axon guidance', 'axonal fasciculation', 'axonogenesis involved in innervation', 'basal dendrite arborization', 'basal dendrite development', 'branching involved in blood vessel morphogenesis', 'branchiomotor neuron axon guidance', 'cell migration involved in sprouting angiogenesis', 'cell-cell signaling', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to vascular endothelial growth factor stimulus', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'dichotomous subdivision of terminal units involved in salivary gland branching', 'dorsal root ganglion morphogenesis', 'endothelial cell chemotaxis', 'endothelial cell migration', 'endothelial tip cell fate specification', 'facial nerve structural organization', 'facioacoustic ganglion development', 'gonadotrophin-releasing hormone neuronal migration to the hypothalamus', 'hepatocyte growth factor receptor signaling pathway', 'integrin-mediated signaling pathway', 'motor neuron migration', 'negative regulation of axon extension involved in axon guidance', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of neuron apoptotic process', 'nerve development', 'neural crest cell migration', 'neural crest cell migration involved in autonomic nervous system development', 'neuron migration', 'neuropilin signaling pathway', 'otic placode development', 'outflow tract septum morphogenesis', 'platelet-derived growth factor receptor signaling pathway', 'positive chemotaxis', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cytokine activity', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of filopodium assembly', 'positive regulation of focal adhesion assembly', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of smooth muscle cell migration', 'positive regulation of stress fiber assembly', 'positive regulation of substrate adhesion-dependent cell spreading', 'postsynapse organization', 'protein localization to early endosome', 'regulation of Cdc42 protein signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of vesicle-mediated transport', 'renal artery morphogenesis', 'response to wounding', 'retina vasculature morphogenesis in camera-type eye', 'retinal ganglion cell axon guidance', 'semaphorin-plexin signaling pathway', 'semaphorin-plexin signaling pathway involved in axon guidance', 'semaphorin-plexin signaling pathway involved in neuron projection guidance', 'sensory neuron axon guidance', 'signal transduction', 'sprouting angiogenesis', 'substrate adhesion-dependent cell spreading', 'substrate-dependent cell migration, cell extension', 'sympathetic ganglion development', 'sympathetic neuron projection extension', 'sympathetic neuron projection guidance', 'toxin transport', 'trigeminal ganglion development', 'trigeminal nerve structural organization', 'vascular endothelial growth factor receptor signaling pathway', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway', 'VEGF-activated neuropilin signaling pathway involved in axon guidance', 'ventral trunk neural crest cell migration', 'vestibulocochlear nerve structural organization', 'viral entry into host cell']['actin cytoskeleton reorganization', 'angiogenesis', 'angiogenesis involved in coronary vascular morphogenesis', 'animal organ morphogenesis', 'artery morphogenesis', 'axon extension involved in axon guidance', 'axon guidance', 'axonal fasciculation', 'axonogenesis involved in innervation', 'basal dendrite arborization', 'basal dendrite development', 'branching involved in blood vessel morphogenesis', 'branchiomotor neuron axon guidance', 'cell migration involved in sprouting angiogenesis', 'cell-cell signaling', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to vascular endothelial growth factor stimulus', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'dichotomous subdivision of terminal units involved in salivary gland branching', 'dorsal root ganglion morphogenesis', 'endothelial cell chemotaxis', 'endothelial cell migration', 'endothelial tip cell fate specification', 'facial nerve structural organization', 'facioacoustic ganglion development', 'gonadotrophin-releasing hormone neuronal migration to the hypothalamus', 'hepatocyte growth factor receptor signaling pathway', 'integrin-mediated signaling pathway', 'motor neuron migration', 'negative regulation of axon extension involved in axon guidance', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of neuron apoptotic process', 'nerve development', 'neural crest cell migration', 'neural crest cell migration involved in autonomic nervous system development', 'neuron migration', 'neuropilin signaling pathway', 'otic placode development', 'outflow tract septum morphogenesis', 'platelet-derived growth factor receptor signaling pathway', 'positive chemotaxis', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cytokine activity', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of filopodium assembly', 'positive regulation of focal adhesion assembly', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of smooth muscle cell migration', 'positive regulation of stress fiber assembly', 'positive regulation of substrate adhesion-dependent cell spreading', 'postsynapse organization', 'protein localization to early endosome', 'regulation of Cdc42 protein signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of vesicle-mediated transport', 'renal artery morphogenesis', 'response to wounding', 'retina vasculature morphogenesis in camera-type eye', 'retinal ganglion cell axon guidance', 'semaphorin-plexin signaling pathway', 'semaphorin-plexin signaling pathway involved in axon guidance', 'semaphorin-plexin signaling pathway involved in neuron projection guidance', 'sensory neuron axon guidance', 'signal transduction', 'sprouting angiogenesis', 'substrate adhesion-dependent cell spreading', 'substrate-dependent cell migration, cell extension', 'sympathetic ganglion development', 'sympathetic neuron projection extension', 'sympathetic neuron projection guidance', 'toxin transport', 'trigeminal ganglion development', 'trigeminal nerve structural organization', 'vascular endothelial growth factor receptor signaling pathway', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway', 'VEGF-activated neuropilin signaling pathway involved in axon guidance', 'ventral trunk neural crest cell migration', 'vestibulocochlear nerve structural organization', 'viral entry into host cell']
Endothelin-1
55
Endothelin-1
67
7.0
55
0.26
P05305P05305['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'artery smooth muscle contraction', 'axon extension', 'axonogenesis involved in innervation', 'body fluid secretion', 'branching involved in blood vessel morphogenesis', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cardiac neural crest cell migration involved in outflow tract morphogenesis', 'cartilage development', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to calcium ion', 'cellular response to fatty acid', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to human chorionic gonadotropin stimulus', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to luteinizing hormone stimulus', 'cellular response to mineralocorticoid stimulus', 'cellular response to organic substance', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to xenobiotic stimulus', 'dorsal/ventral pattern formation', 'embryonic heart tube development', 'endothelin receptor signaling pathway', 'endothelin receptor signaling pathway involved in heart process', 'epithelial fluid transport', 'ERK1 and ERK2 cascade', 'G protein-coupled receptor signaling pathway', 'histamine secretion', 'I-kappaB kinase/NF-kappaB signaling', 'in utero embryonic development', 'inositol phosphate-mediated signaling', 'leukocyte activation', 'maternal process involved in parturition', 'meiotic cell cycle process involved in oocyte maturation', 'membrane depolarization', 'middle ear morphogenesis', 'mitochondrion organization', 'multicellular organism aging', 'negative regulation of blood coagulation', 'negative regulation of gene expression', 'negative regulation of hormone secretion', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein metabolic process', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'neural crest cell fate commitment', 'nitric oxide transport', 'noradrenergic neuron differentiation', 'peptide hormone secretion', 'pharyngeal arch artery morphogenesis', 'phosphatidylinositol 3-kinase signaling', 'phospholipase D-activating G protein-coupled receptor signaling pathway', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cation channel activity', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell size', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell migration', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of JUN kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of odontogenesis', 'positive regulation of prostaglandin secretion', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'positive regulation of renal sodium excretion', 'positive regulation of sarcomere organization', 'positive regulation of signaling receptor activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'prostaglandin biosynthetic process', 'protein kinase A signaling', 'protein kinase C deactivation', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'regulation of glucose transmembrane transport', 'regulation of pH', 'regulation of sensory perception of pain', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'renal sodium ion absorption', 'respiratory gaseous exchange by respiratory system', 'response to activity', 'response to amino acid', 'response to amphetamine', 'response to dexamethasone', 'response to leptin', 'response to lipopolysaccharide', 'response to muscle stretch', 'response to nicotine', 'response to ozone', 'response to prostaglandin F', 'response to salt', 'response to testosterone', 'rhythmic excitation', 'semaphorin-plexin signaling pathway involved in axon guidance', 'sensory perception of pain', 'superoxide anion generation', 'sympathetic neuron axon guidance', 'thyroid gland development', 'transcription by RNA polymerase II', 'vasoconstriction', 'vein smooth muscle contraction']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'artery smooth muscle contraction', 'axon extension', 'axonogenesis involved in innervation', 'body fluid secretion', 'branching involved in blood vessel morphogenesis', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cardiac neural crest cell migration involved in outflow tract morphogenesis', 'cartilage development', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to calcium ion', 'cellular response to fatty acid', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to human chorionic gonadotropin stimulus', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to luteinizing hormone stimulus', 'cellular response to mineralocorticoid stimulus', 'cellular response to organic substance', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to xenobiotic stimulus', 'dorsal/ventral pattern formation', 'embryonic heart tube development', 'endothelin receptor signaling pathway', 'endothelin receptor signaling pathway involved in heart process', 'epithelial fluid transport', 'ERK1 and ERK2 cascade', 'G protein-coupled receptor signaling pathway', 'histamine secretion', 'I-kappaB kinase/NF-kappaB signaling', 'in utero embryonic development', 'inositol phosphate-mediated signaling', 'leukocyte activation', 'maternal process involved in parturition', 'meiotic cell cycle process involved in oocyte maturation', 'membrane depolarization', 'middle ear morphogenesis', 'mitochondrion organization', 'multicellular organism aging', 'negative regulation of blood coagulation', 'negative regulation of gene expression', 'negative regulation of hormone secretion', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein metabolic process', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'neural crest cell fate commitment', 'nitric oxide transport', 'noradrenergic neuron differentiation', 'peptide hormone secretion', 'pharyngeal arch artery morphogenesis', 'phosphatidylinositol 3-kinase signaling', 'phospholipase D-activating G protein-coupled receptor signaling pathway', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cation channel activity', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell size', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell migration', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of JUN kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of odontogenesis', 'positive regulation of prostaglandin secretion', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'positive regulation of renal sodium excretion', 'positive regulation of sarcomere organization', 'positive regulation of signaling receptor activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'prostaglandin biosynthetic process', 'protein kinase A signaling', 'protein kinase C deactivation', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'regulation of glucose transmembrane transport', 'regulation of pH', 'regulation of sensory perception of pain', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'renal sodium ion absorption', 'respiratory gaseous exchange by respiratory system', 'response to activity', 'response to amino acid', 'response to amphetamine', 'response to dexamethasone', 'response to leptin', 'response to lipopolysaccharide', 'response to muscle stretch', 'response to nicotine', 'response to ozone', 'response to prostaglandin F', 'response to salt', 'response to testosterone', 'rhythmic excitation', 'semaphorin-plexin signaling pathway involved in axon guidance', 'sensory perception of pain', 'superoxide anion generation', 'sympathetic neuron axon guidance', 'thyroid gland development', 'transcription by RNA polymerase II', 'vasoconstriction', 'vein smooth muscle contraction']
C-C chemokine receptor type 5
20
C-C motif chemokine 5
34
9.2
71
0.15
P51681P13501['calcium ion transport', 'calcium-mediated signaling', 'cell chemotaxis', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular defense response', 'cellular response to lipopolysaccharide', 'chemotaxis', 'dendritic cell chemotaxis', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'MAPK cascade', 'positive regulation of cytosolic calcium ion concentration', 'release of sequestered calcium ion into cytosol by sarcoplasmic reticulum', 'response to cholesterol', 'signaling']['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'chemokine-mediated signaling pathway', 'chemotaxis', 'dendritic cell chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of innate immune response', 'positive regulation of macrophage chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of translational initiation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of viral genome replication', 'protein kinase B signaling', 'regulation of chronic inflammatory response', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to toxic substance', 'response to virus']
Ral guanine nucleotide dissociation stimulator
780
Ral guanine nucleotide dissociation stimulator
781
6.3
61
0.26
Q03386Q03386['positive regulation of GTPase activity', 'Ras protein signal transduction', 'small GTPase mediated signal transduction']['positive regulation of GTPase activity', 'Ras protein signal transduction', 'small GTPase mediated signal transduction']
Translationally-controlled tumor protein
28
Translationally-controlled tumor protein
28
2.0
81
0.61
P13693P13693['calcium ion transport', 'cellular calcium ion homeostasis', 'negative regulation of apoptotic process', 'negative regulation of ectoderm development', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'regulation of apoptotic process', 'response to virus', 'stem cell population maintenance']['calcium ion transport', 'cellular calcium ion homeostasis', 'negative regulation of apoptotic process', 'negative regulation of ectoderm development', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'regulation of apoptotic process', 'response to virus', 'stem cell population maintenance']
Amyloid-beta precursor protein
174
Amyloid-beta precursor protein
133
7.3
77
0.18
P05067P05067['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Lactotransferrin
424
Lactotransferrin
703
2.1
45
1.05
P24627P24627['antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'bone morphogenesis', 'defense response to Gram-negative bacterium', 'innate immune response in mucosa', 'iron ion homeostasis', 'iron ion transport', 'killing of cells of another organism', 'membrane disruption in another organism', 'negative regulation by host of viral process', 'negative regulation of apoptotic process', 'negative regulation of ATP-dependent activity', 'negative regulation of cysteine-type endopeptidase activity', 'negative regulation of lipopolysaccharide-mediated signaling pathway', 'negative regulation of osteoclast development', 'negative regulation of single-species biofilm formation in or on host organism', 'negative regulation of tumor necrosis factor (ligand) superfamily member 11 production', 'negative regulation of viral genome replication', 'ossification', 'positive regulation of bone mineralization involved in bone maturation', 'positive regulation of chondrocyte proliferation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of osteoblast differentiation', 'positive regulation of osteoblast proliferation', 'positive regulation of toll-like receptor 4 signaling pathway', 'proteolysis', 'regulation of cytokine production', 'regulation of tumor necrosis factor production']['antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'bone morphogenesis', 'defense response to Gram-negative bacterium', 'innate immune response in mucosa', 'iron ion homeostasis', 'iron ion transport', 'killing of cells of another organism', 'membrane disruption in another organism', 'negative regulation by host of viral process', 'negative regulation of apoptotic process', 'negative regulation of ATP-dependent activity', 'negative regulation of cysteine-type endopeptidase activity', 'negative regulation of lipopolysaccharide-mediated signaling pathway', 'negative regulation of osteoclast development', 'negative regulation of single-species biofilm formation in or on host organism', 'negative regulation of tumor necrosis factor (ligand) superfamily member 11 production', 'negative regulation of viral genome replication', 'ossification', 'positive regulation of bone mineralization involved in bone maturation', 'positive regulation of chondrocyte proliferation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of osteoblast differentiation', 'positive regulation of osteoblast proliferation', 'positive regulation of toll-like receptor 4 signaling pathway', 'proteolysis', 'regulation of cytokine production', 'regulation of tumor necrosis factor production']
Chymotrypsin-C
141
Chymotrypsin-C
17
2.1
nan
nan
Q99895Q99895['cellular calcium ion homeostasis', 'cobalamin metabolic process', 'proteolysis']['cellular calcium ion homeostasis', 'cobalamin metabolic process', 'proteolysis']
Interleukin-4
27
Cytokine receptor common subunit gamma
182
8.5
nan
nan
P05112P31785['activation of Janus kinase activity', 'B cell costimulation', 'B cell differentiation', 'cholesterol metabolic process', 'dendritic cell differentiation', 'extrinsic apoptotic signaling pathway in absence of ligand', 'immune response', 'innate immune response in mucosa', 'macrophage activation', 'microglial cell activation', 'myeloid dendritic cell differentiation', 'negative regulation of acute inflammatory response', 'negative regulation of apoptotic process', 'negative regulation of cellular response to transforming growth factor beta stimulus', 'negative regulation of chronic inflammatory response', 'negative regulation of complement-dependent cytotoxicity', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of epithelial cell migration', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of inflammatory response', 'negative regulation of macrophage activation', 'negative regulation of neuroinflammatory response', 'negative regulation of osteoclast differentiation', 'negative regulation of T-helper 17 cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of tumor necrosis factor production', 'neuroinflammatory response', 'positive regulation of amyloid-beta clearance', 'positive regulation of ATP biosynthetic process', 'positive regulation of B cell proliferation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cellular respiration', 'positive regulation of cold-induced thermogenesis', 'positive regulation of defense response to virus by host', 'positive regulation of eosinophil chemotaxis', 'positive regulation of gene expression', 'positive regulation of interleukin-10 production', 'positive regulation of interleukin-13 production', 'positive regulation of isotype switching to IgE isotypes', 'positive regulation of isotype switching to IgG isotypes', 'positive regulation of macroautophagy', 'positive regulation of mast cell degranulation', 'positive regulation of MHC class II biosynthetic process', 'positive regulation of mononuclear cell migration', 'positive regulation of myoblast fusion', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of T cell differentiation', 'positive regulation of T cell proliferation', 'positive regulation of T-helper 2 cell cytokine production', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of tyrosine phosphorylation of STAT protein', 'regulation of immune response', 'regulation of isotype switching', 'regulation of phosphorylation', 'T cell activation', 'T-helper 2 cell differentiation', 'type 2 immune response']['CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation', 'cytokine-mediated signaling pathway', 'gene expression', 'immune response', 'interleukin-15-mediated signaling pathway', 'interleukin-2-mediated signaling pathway', 'interleukin-4-mediated signaling pathway', 'interleukin-7-mediated signaling pathway', 'mature B cell differentiation', 'positive regulation of B cell differentiation', 'positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation', 'positive regulation of gene expression', 'positive regulation of phagocytosis', 'positive regulation of T cell differentiation in thymus', 'signal transduction', 'T cell differentiation in thymus']
Enteropeptidase
788
Enteropeptidase
912
2.6
nan
nan
P98072P98072['protein digestion', 'trypsinogen activation']['protein digestion', 'trypsinogen activation']
Platelet factor 4 variant
46
Platelet factor 4 variant
46
9.8
71
0.14
P10720P10720['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'inflammatory response', 'neutrophil chemotaxis', 'platelet activation']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'inflammatory response', 'neutrophil chemotaxis', 'platelet activation']
Interleukin-4
27
Cytokine receptor common subunit gamma
231
8.8
nan
nan
D4HNR6P31785['B cell activation', 'immune response']['CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation', 'cytokine-mediated signaling pathway', 'gene expression', 'immune response', 'interleukin-15-mediated signaling pathway', 'interleukin-2-mediated signaling pathway', 'interleukin-4-mediated signaling pathway', 'interleukin-7-mediated signaling pathway', 'mature B cell differentiation', 'positive regulation of B cell differentiation', 'positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation', 'positive regulation of gene expression', 'positive regulation of phagocytosis', 'positive regulation of T cell differentiation in thymus', 'signal transduction', 'T cell differentiation in thymus']
Chymotrypsinogen B
1
Chymotrypsinogen A
122
2.0
nan
nan
P00767P00766['digestion', 'proteolysis']['digestion', 'proteolysis']
Immunoglobulin kappa constant
107
Ig gamma-1 chain C region, membrane-bound form
102
3.7
nan
nan
P01837P01869['adaptive immune response', 'B cell differentiation', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['antibacterial humoral response', 'antibody-dependent cellular cytotoxicity', 'B cell differentiation', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'humoral immune response mediated by circulating immunoglobulin', 'immunoglobulin mediated immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of immune response', 'positive regulation of phagocytosis', 'positive regulation of type I hypersensitivity', 'positive regulation of type IIa hypersensitivity']
Uncharacterized protein
239
IgG H chain
239
6.9
nan
nan
Q8TCD0S6B291[][]
Protein farnesyltransferase subunit beta
95
GTPase KRas
186
7.1
62
0.23
Q02293P01118['lipid metabolic process', 'negative regulation of cell population proliferation', 'positive regulation of cell cycle', 'positive regulation of cell population proliferation', 'positive regulation of fibroblast proliferation', 'positive regulation of nitric-oxide synthase biosynthetic process', 'protein farnesylation', 'protein prenylation', 'regulation of fibroblast proliferation', 'response to cytokine', 'response to inorganic substance', 'response to organic cyclic compound', 'wound healing']['actin cytoskeleton organization', 'endocrine signaling', 'epithelial tube branching involved in lung morphogenesis', 'forebrain astrocyte development', 'glial cell proliferation', 'homeostasis of number of cells within a tissue', 'MAPK cascade', 'negative regulation of epithelial cell differentiation', 'negative regulation of neuron apoptotic process', 'neuron apoptotic process', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of glial cell proliferation', 'positive regulation of protein phosphorylation', 'positive regulation of Rac protein signal transduction', 'Rac protein signal transduction', 'Ras protein signal transduction', 'regulation of long-term neuronal synaptic plasticity', 'regulation of protein stability', 'regulation of synaptic transmission, GABAergic', 'skeletal muscle cell differentiation', 'striated muscle cell differentiation', 'type I pneumocyte differentiation', 'visual learning']
Protein farnesyltransferase subunit beta
366
GTPase KRas
186
9.7
82
0.13
Q02293P01116['lipid metabolic process', 'negative regulation of cell population proliferation', 'positive regulation of cell cycle', 'positive regulation of cell population proliferation', 'positive regulation of fibroblast proliferation', 'positive regulation of nitric-oxide synthase biosynthetic process', 'protein farnesylation', 'protein prenylation', 'regulation of fibroblast proliferation', 'response to cytokine', 'response to inorganic substance', 'response to organic cyclic compound', 'wound healing']['actin cytoskeleton organization', 'endocrine signaling', 'epithelial tube branching involved in lung morphogenesis', 'forebrain astrocyte development', 'glial cell proliferation', 'homeostasis of number of cells within a tissue', 'MAPK cascade', 'negative regulation of epithelial cell differentiation', 'negative regulation of neuron apoptotic process', 'neuron apoptotic process', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of glial cell proliferation', 'positive regulation of protein phosphorylation', 'positive regulation of Rac protein signal transduction', 'Rac protein signal transduction', 'Ras protein signal transduction', 'regulation of long-term neuronal synaptic plasticity', 'regulation of protein stability', 'regulation of synaptic transmission, GABAergic', 'skeletal muscle cell differentiation', 'striated muscle cell differentiation', 'type I pneumocyte differentiation', 'visual learning']
Protein kinase C delta type
272
Protein kinase C delta type
280
9.2
nan
nan
A0A140UHX0A0A140UHX0['apoptotic process', 'cell cycle', 'protein phosphorylation']['apoptotic process', 'cell cycle', 'protein phosphorylation']
Mucin-2
1130
Mucin-2
1130
2.0
nan
nan
Q02817Q02817['maintenance of gastrointestinal epithelium']['maintenance of gastrointestinal epithelium']
Immunoglobulin heavy constant alpha 1
123
Immunoglobulin heavy constant alpha 1
180
2.0
nan
nan
P01876P01876['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']
Thrombomodulin
480
Thrombomodulin
451
10.0
66
0.15
P07204P07204['blood coagulation', 'blood coagulation, common pathway', 'female pregnancy', 'negative regulation of blood coagulation', 'negative regulation of fibrinolysis', 'negative regulation of platelet activation', 'proteolysis', 'response to cAMP', 'response to lipopolysaccharide', 'response to X-ray', 'zymogen activation']['blood coagulation', 'blood coagulation, common pathway', 'female pregnancy', 'negative regulation of blood coagulation', 'negative regulation of fibrinolysis', 'negative regulation of platelet activation', 'proteolysis', 'response to cAMP', 'response to lipopolysaccharide', 'response to X-ray', 'zymogen activation']
Protein farnesyltransferase subunit beta
299
GTPase KRas
186
9.0
71
0.16
Q02293P01118['lipid metabolic process', 'negative regulation of cell population proliferation', 'positive regulation of cell cycle', 'positive regulation of cell population proliferation', 'positive regulation of fibroblast proliferation', 'positive regulation of nitric-oxide synthase biosynthetic process', 'protein farnesylation', 'protein prenylation', 'regulation of fibroblast proliferation', 'response to cytokine', 'response to inorganic substance', 'response to organic cyclic compound', 'wound healing']['actin cytoskeleton organization', 'endocrine signaling', 'epithelial tube branching involved in lung morphogenesis', 'forebrain astrocyte development', 'glial cell proliferation', 'homeostasis of number of cells within a tissue', 'MAPK cascade', 'negative regulation of epithelial cell differentiation', 'negative regulation of neuron apoptotic process', 'neuron apoptotic process', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of glial cell proliferation', 'positive regulation of protein phosphorylation', 'positive regulation of Rac protein signal transduction', 'Rac protein signal transduction', 'Ras protein signal transduction', 'regulation of long-term neuronal synaptic plasticity', 'regulation of protein stability', 'regulation of synaptic transmission, GABAergic', 'skeletal muscle cell differentiation', 'striated muscle cell differentiation', 'type I pneumocyte differentiation', 'visual learning']
Chymotrypsinogen B
19
Chymotrypsinogen B
140
2.0
66
0.74
P07338P07338['digestion', 'positive regulation of apoptotic process', 'protein catabolic process', 'proteolysis', 'response to cytokine', 'response to food', 'response to nutrient', 'response to peptide hormone', 'response to toxic substance']['digestion', 'positive regulation of apoptotic process', 'protein catabolic process', 'proteolysis', 'response to cytokine', 'response to food', 'response to nutrient', 'response to peptide hormone', 'response to toxic substance']
Neutrophil defensin 1
93
Neutrophil defensin 1
66
9.4
67
0.16
P59665P59665['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']
Neutrophil defensin 3
94
Neutrophil defensin 3
66
9.8
nan
nan
P59666P59666['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to virus', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing of cells of another organism', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to virus', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing of cells of another organism', 'membrane disruption in another organism']
Glycylpeptide N-tetradecanoyltransferase 1
294
Apoptosis-inducing factor 3
4
10.0
78
0.13
P30419Q96NN9['cellular ketone metabolic process', 'in utero embryonic development', 'N-terminal peptidyl-glycine N-myristoylation', 'N-terminal protein myristoylation', 'positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway', 'regulation of rhodopsin mediated signaling pathway']['execution phase of apoptosis']
Interleukin-4
27
Cytokine receptor common subunit gamma
231
7.9
nan
nan
P05112P31785['activation of Janus kinase activity', 'B cell costimulation', 'B cell differentiation', 'cholesterol metabolic process', 'dendritic cell differentiation', 'extrinsic apoptotic signaling pathway in absence of ligand', 'immune response', 'innate immune response in mucosa', 'macrophage activation', 'microglial cell activation', 'myeloid dendritic cell differentiation', 'negative regulation of acute inflammatory response', 'negative regulation of apoptotic process', 'negative regulation of cellular response to transforming growth factor beta stimulus', 'negative regulation of chronic inflammatory response', 'negative regulation of complement-dependent cytotoxicity', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of epithelial cell migration', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of inflammatory response', 'negative regulation of macrophage activation', 'negative regulation of neuroinflammatory response', 'negative regulation of osteoclast differentiation', 'negative regulation of T-helper 17 cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of tumor necrosis factor production', 'neuroinflammatory response', 'positive regulation of amyloid-beta clearance', 'positive regulation of ATP biosynthetic process', 'positive regulation of B cell proliferation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cellular respiration', 'positive regulation of cold-induced thermogenesis', 'positive regulation of defense response to virus by host', 'positive regulation of eosinophil chemotaxis', 'positive regulation of gene expression', 'positive regulation of interleukin-10 production', 'positive regulation of interleukin-13 production', 'positive regulation of isotype switching to IgE isotypes', 'positive regulation of isotype switching to IgG isotypes', 'positive regulation of macroautophagy', 'positive regulation of mast cell degranulation', 'positive regulation of MHC class II biosynthetic process', 'positive regulation of mononuclear cell migration', 'positive regulation of myoblast fusion', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of T cell differentiation', 'positive regulation of T cell proliferation', 'positive regulation of T-helper 2 cell cytokine production', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of tyrosine phosphorylation of STAT protein', 'regulation of immune response', 'regulation of isotype switching', 'regulation of phosphorylation', 'T cell activation', 'T-helper 2 cell differentiation', 'type 2 immune response']['CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation', 'cytokine-mediated signaling pathway', 'gene expression', 'immune response', 'interleukin-15-mediated signaling pathway', 'interleukin-2-mediated signaling pathway', 'interleukin-4-mediated signaling pathway', 'interleukin-7-mediated signaling pathway', 'mature B cell differentiation', 'positive regulation of B cell differentiation', 'positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation', 'positive regulation of gene expression', 'positive regulation of phagocytosis', 'positive regulation of T cell differentiation in thymus', 'signal transduction', 'T cell differentiation in thymus']
Uncharacterized protein
239
Immunoglobulin gamma-1 heavy chain
222
2.0
nan
nan
Q8TCD0P0DOX5[]['adaptive immune response']
C-C chemokine receptor type 5
269
C-C motif chemokine 5
33
8.9
67
0.17
P51681P13501['calcium ion transport', 'calcium-mediated signaling', 'cell chemotaxis', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular defense response', 'cellular response to lipopolysaccharide', 'chemotaxis', 'dendritic cell chemotaxis', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'MAPK cascade', 'positive regulation of cytosolic calcium ion concentration', 'release of sequestered calcium ion into cytosol by sarcoplasmic reticulum', 'response to cholesterol', 'signaling']['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'chemokine-mediated signaling pathway', 'chemotaxis', 'dendritic cell chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of innate immune response', 'positive regulation of macrophage chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of translational initiation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of viral genome replication', 'protein kinase B signaling', 'regulation of chronic inflammatory response', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to toxic substance', 'response to virus']
Ephrin type-A receptor 2
201
Ephrin-A1
80
9.9
nan
nan
P29317P20827['activation of GTPase activity', 'axial mesoderm formation', 'axon guidance', 'blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'bone remodeling', 'branching involved in mammary gland duct morphogenesis', 'cAMP metabolic process', 'cell adhesion', 'cell chemotaxis', 'cell migration', 'cell motility', 'defense response to Gram-positive bacterium', 'ephrin receptor signaling pathway', 'inflammatory response', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'keratinocyte differentiation', 'lens fiber cell morphogenesis', 'mammary gland epithelial cell proliferation', 'negative regulation of angiogenesis', 'negative regulation of chemokine production', 'negative regulation of lymphangiogenesis', 'negative regulation of protein kinase B signaling', 'neural tube development', 'notochord cell development', 'notochord formation', 'osteoblast differentiation', 'osteoclast differentiation', 'pericyte cell differentiation', 'positive regulation of bicellular tight junction assembly', 'positive regulation of cell migration', 'positive regulation of kinase activity', 'positive regulation of protein localization to plasma membrane', 'post-anal tail morphogenesis', 'protein kinase B signaling', 'protein localization to plasma membrane', 'regulation of angiogenesis', 'regulation of blood vessel endothelial cell migration', 'regulation of cell adhesion mediated by integrin', 'regulation of ERK1 and ERK2 cascade', 'regulation of lamellipodium assembly', 'response to growth factor', 'skeletal system development', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'vasculogenesis']['angiogenesis', 'aortic valve morphogenesis', 'axon guidance', 'cell migration', 'cell-cell signaling', 'endocardial cushion to mesenchymal transition involved in heart valve formation', 'ephrin receptor signaling pathway', 'mitral valve morphogenesis', 'negative regulation of dendritic spine morphogenesis', 'negative regulation of epithelial to mesenchymal transition', 'negative regulation of MAPK cascade', 'negative regulation of proteolysis involved in protein catabolic process', 'negative regulation of thymocyte apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'notochord formation', 'positive regulation of amyloid-beta formation', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of MAPK cascade', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'protein stabilization', 'regulation of angiogenesis', 'regulation of axonogenesis', 'regulation of blood vessel endothelial cell migration', 'regulation of cell adhesion mediated by integrin', 'regulation of peptidyl-tyrosine phosphorylation', 'substrate adhesion-dependent cell spreading']
Immunoglobulin kappa constant
107
IgG H chain
239
2.0
nan
nan
P01834S6B291['adaptive immune response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'retina homeostasis'][]
Interleukin-4
27
Cytokine receptor common subunit gamma
182
9.2
nan
nan
D4HNR6P31785['B cell activation', 'immune response']['CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation', 'cytokine-mediated signaling pathway', 'gene expression', 'immune response', 'interleukin-15-mediated signaling pathway', 'interleukin-2-mediated signaling pathway', 'interleukin-4-mediated signaling pathway', 'interleukin-7-mediated signaling pathway', 'mature B cell differentiation', 'positive regulation of B cell differentiation', 'positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation', 'positive regulation of gene expression', 'positive regulation of phagocytosis', 'positive regulation of T cell differentiation in thymus', 'signal transduction', 'T cell differentiation in thymus']
Thioredoxin domain-containing protein 5
217
Peroxiredoxin-4
248
2.1
45
1.05
Q8NBS9O08807['negative regulation of apoptotic process', 'protein folding']['cell redox homeostasis', 'extracellular matrix organization', 'male gonad development', 'negative regulation of male germ cell proliferation', 'peptidyl-proline hydroxylation to 4-hydroxy-L-proline', 'protein maturation by protein folding', 'reactive oxygen species metabolic process', 'response to oxidative stress', 'spermatogenesis']
Immunoglobulin lambda constant 3
105
Uncharacterized protein
245
2.0
nan
nan
P0DOY3A8K008['adaptive immune response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation'][]
Interleukin-4
151
Cytokine receptor common subunit gamma
231
8.3
nan
nan
D4HNR6P31785['B cell activation', 'immune response']['CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation', 'cytokine-mediated signaling pathway', 'gene expression', 'immune response', 'interleukin-15-mediated signaling pathway', 'interleukin-2-mediated signaling pathway', 'interleukin-4-mediated signaling pathway', 'interleukin-7-mediated signaling pathway', 'mature B cell differentiation', 'positive regulation of B cell differentiation', 'positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation', 'positive regulation of gene expression', 'positive regulation of phagocytosis', 'positive regulation of T cell differentiation in thymus', 'signal transduction', 'T cell differentiation in thymus']
Glycoprotein hormones alpha chain
31
Follitropin subunit beta
21
9.8
54
0.19
Q96QJ4P01225[]['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Ubiquitin-conjugating enzyme E2 S
95
Polyubiquitin-B
229
2.0
nan
nan
Q16763P0CG47['anaphase-promoting complex-dependent catabolic process', 'cell division', 'exit from mitosis', 'free ubiquitin chain polymerization', 'positive regulation of ubiquitin protein ligase activity', 'protein K11-linked ubiquitination', 'protein K27-linked ubiquitination', 'protein K29-linked ubiquitination', 'protein K6-linked ubiquitination', 'protein K63-linked ubiquitination', 'protein modification process', 'protein polyubiquitination', 'ubiquitin-dependent protein catabolic process']['energy homeostasis', 'fat pad development', 'female gonad development', 'female meiosis I', 'hypothalamus gonadotrophin-releasing hormone neuron development', 'male meiosis I', 'mitochondrion transport along microtubule', 'modification-dependent protein catabolic process', 'neuron projection morphogenesis', 'positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'positive regulation of protein monoubiquitination', 'positive regulation of protein ubiquitination', 'protein ubiquitination', 'regulation of mitochondrial membrane potential', 'regulation of neuron death', 'regulation of proteasomal protein catabolic process', 'seminiferous tubule development']
T-box transcription factor TBX5
202
T-box transcription factor TBX5
202
2.1
71
0.67
Q99593Q99593['atrial septum morphogenesis', 'atrioventricular bundle cell differentiation', 'atrioventricular node cell development', 'atrioventricular node cell fate commitment', 'atrioventricular valve morphogenesis', 'bundle of His cell to Purkinje myocyte communication by electrical coupling', 'bundle of His development', 'cardiac left ventricle formation', 'cardiac muscle cell proliferation', 'cell fate specification', 'cell migration involved in coronary vasculogenesis', 'cell-cell signaling', 'cell-cell signaling involved in cardiac conduction', 'embryonic forelimb morphogenesis', 'embryonic limb morphogenesis', 'endocardial cushion development', 'forelimb morphogenesis', 'heart development', 'lung development', 'morphogenesis of an epithelium', 'negative regulation of cardiac muscle cell proliferation', 'negative regulation of cell migration', 'negative regulation of cell population proliferation', 'negative regulation of epithelial to mesenchymal transition', 'pattern specification process', 'pericardium development', 'positive regulation of cardiac conduction', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cardioblast differentiation', 'positive regulation of cell communication by electrical coupling involved in cardiac conduction', 'positive regulation of gap junction assembly', 'positive regulation of secondary heart field cardioblast proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of atrial cardiac muscle cell membrane depolarization', 'regulation of transcription by RNA polymerase II', 'sinoatrial node development', 'transcription by RNA polymerase II', 'ventricular septum development']['atrial septum morphogenesis', 'atrioventricular bundle cell differentiation', 'atrioventricular node cell development', 'atrioventricular node cell fate commitment', 'atrioventricular valve morphogenesis', 'bundle of His cell to Purkinje myocyte communication by electrical coupling', 'bundle of His development', 'cardiac left ventricle formation', 'cardiac muscle cell proliferation', 'cell fate specification', 'cell migration involved in coronary vasculogenesis', 'cell-cell signaling', 'cell-cell signaling involved in cardiac conduction', 'embryonic forelimb morphogenesis', 'embryonic limb morphogenesis', 'endocardial cushion development', 'forelimb morphogenesis', 'heart development', 'lung development', 'morphogenesis of an epithelium', 'negative regulation of cardiac muscle cell proliferation', 'negative regulation of cell migration', 'negative regulation of cell population proliferation', 'negative regulation of epithelial to mesenchymal transition', 'pattern specification process', 'pericardium development', 'positive regulation of cardiac conduction', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cardioblast differentiation', 'positive regulation of cell communication by electrical coupling involved in cardiac conduction', 'positive regulation of gap junction assembly', 'positive regulation of secondary heart field cardioblast proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of atrial cardiac muscle cell membrane depolarization', 'regulation of transcription by RNA polymerase II', 'sinoatrial node development', 'transcription by RNA polymerase II', 'ventricular septum development']
Uncharacterized protein
239
Immunoglobulin heavy constant gamma 1
103
2.1
nan
nan
Q8TCD0P01857[]['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
Sorting nexin-17
320
Krev interaction trapped protein 1
228
3.5
48
0.6
Q15036O00522['aorta development', 'cardiac septum development', 'cholesterol catabolic process', 'coronary vasculature development', 'endocytic recycling', 'endosomal transport', 'intracellular protein transport', 'kidney development', 'receptor-mediated endocytosis', 'regulation of endocytosis', 'signal transduction']['angiogenesis', 'cell redox homeostasis', 'endothelium development', 'integrin activation', 'negative regulation of angiogenesis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of endothelial cell migration', 'negative regulation of endothelial cell proliferation', 'positive regulation of protein binding', 'regulation of angiogenesis', 'regulation of establishment of cell polarity', 'small GTPase mediated signal transduction']
Amyloid beta precursor like protein 2
319
Amyloid beta precursor like protein 2
343
2.1
76
0.63
Q06481Q06481['axonogenesis', 'central nervous system development', 'G protein-coupled receptor signaling pathway', 'regulation of cellular protein metabolic process']['axonogenesis', 'central nervous system development', 'G protein-coupled receptor signaling pathway', 'regulation of cellular protein metabolic process']
E3 ubiquitin-protein ligase HUWE1
4341
Polyubiquitin-B
229
2.0
nan
nan
Q7Z6Z7P0CG47['base-excision repair', 'cell differentiation', 'circadian regulation of gene expression', 'Golgi organization', 'histone ubiquitination', 'membrane fusion', 'negative regulation of mitochondrial fusion', 'positive regulation of mitophagy in response to mitochondrial depolarization', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of protein ubiquitination', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein monoubiquitination', 'protein polyubiquitination', 'protein ubiquitination']['energy homeostasis', 'fat pad development', 'female gonad development', 'female meiosis I', 'hypothalamus gonadotrophin-releasing hormone neuron development', 'male meiosis I', 'mitochondrion transport along microtubule', 'modification-dependent protein catabolic process', 'neuron projection morphogenesis', 'positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'positive regulation of protein monoubiquitination', 'positive regulation of protein ubiquitination', 'protein ubiquitination', 'regulation of mitochondrial membrane potential', 'regulation of neuron death', 'regulation of proteasomal protein catabolic process', 'seminiferous tubule development']
Protein timeless homolog
1038
Protein timeless homolog
1038
2.0
nan
nan
Q9UNS1Q9UNS1['branching morphogenesis of an epithelial tube', 'cell cycle phase transition', 'cell division', 'cellular response to bleomycin', 'cellular response to cisplatin', 'cellular response to DNA damage stimulus', 'cellular response to hydroxyurea', 'circadian rhythm', 'detection of abiotic stimulus', 'DNA repair', 'DNA replication checkpoint signaling', 'lung development', 'morphogenesis of an epithelium', 'negative regulation of transcription, DNA-templated', 'positive regulation of double-strand break repair', 'positive regulation of double-strand break repair via homologous recombination', 'regulation of circadian rhythm', 'replication fork arrest', 'replication fork protection']['branching morphogenesis of an epithelial tube', 'cell cycle phase transition', 'cell division', 'cellular response to bleomycin', 'cellular response to cisplatin', 'cellular response to DNA damage stimulus', 'cellular response to hydroxyurea', 'circadian rhythm', 'detection of abiotic stimulus', 'DNA repair', 'DNA replication checkpoint signaling', 'lung development', 'morphogenesis of an epithelium', 'negative regulation of transcription, DNA-templated', 'positive regulation of double-strand break repair', 'positive regulation of double-strand break repair via homologous recombination', 'regulation of circadian rhythm', 'replication fork arrest', 'replication fork protection']
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
545
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
518
2.9
69
0.5
Q6RHR9Q6RHR9['positive regulation of cell-cell adhesion', 'signal transduction']['positive regulation of cell-cell adhesion', 'signal transduction']
Interleukin-12 subunit beta
199
Interleukin-12 subunit alpha
96
2.0
nan
nan
P29460P29459['cell migration', 'cellular response to interferon-gamma', 'cellular response to lipopolysaccharide', 'cytokine-mediated signaling pathway', 'defense response to Gram-negative bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'natural killer cell activation', 'natural killer cell activation involved in immune response', 'negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'negative regulation of inflammatory response to antigenic stimulus', 'negative regulation of interleukin-10 production', 'negative regulation of interleukin-17 production', 'negative regulation of protein secretion', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of vascular endothelial growth factor signaling pathway', 'positive regulation of activated T cell proliferation', 'positive regulation of activation of Janus kinase activity', 'positive regulation of cell adhesion', 'positive regulation of defense response to virus by host', 'positive regulation of granulocyte macrophage colony-stimulating factor production', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-10 production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-17 production', 'positive regulation of lymphocyte proliferation', 'positive regulation of memory T cell differentiation', 'positive regulation of mononuclear cell proliferation', 'positive regulation of natural killer cell activation', 'positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target', 'positive regulation of natural killer cell proliferation', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of NK T cell activation', 'positive regulation of NK T cell proliferation', 'positive regulation of osteoclast differentiation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell apoptotic process', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of T cell proliferation', 'positive regulation of T-helper 1 type immune response', 'positive regulation of T-helper 17 cell lineage commitment', 'positive regulation of T-helper 17 type immune response', 'positive regulation of tissue remodeling', 'positive regulation of tumor necrosis factor production', 'positive regulation of tyrosine phosphorylation of STAT protein', 'regulation of cytokine production', 'regulation of tyrosine phosphorylation of STAT protein', 'response to UV-B', 'sensory perception of pain', 'sexual reproduction', 'T cell proliferation', 'T-helper 1 type immune response', 'T-helper cell differentiation']['cell migration', 'cellular response to virus', 'defense response to Gram-positive bacterium', 'extrinsic apoptotic signaling pathway', 'immune response', 'negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'negative regulation of interleukin-17 production', 'negative regulation of protein secretion', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of vascular endothelial growth factor signaling pathway', 'positive regulation of cell adhesion', 'positive regulation of dendritic cell chemotaxis', 'positive regulation of interferon-gamma production', 'positive regulation of lymphocyte proliferation', 'positive regulation of mononuclear cell proliferation', 'positive regulation of natural killer cell activation', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target', 'positive regulation of natural killer cell proliferation', 'positive regulation of NK T cell activation', 'positive regulation of NK T cell proliferation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell apoptotic process', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of T cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'response to lipopolysaccharide', 'response to UV-B', 'response to virus']
E3 ubiquitin-protein ligase NEDD4
1286
Polyubiquitin-B
305
2.0
nan
nan
P46934P0CG53['cellular response to UV', 'formation of structure involved in a symbiotic process', 'glucocorticoid receptor signaling pathway', 'lysosomal transport', 'negative regulation of sodium ion transmembrane transporter activity', 'negative regulation of sodium ion transport', 'negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage', 'negative regulation of vascular endothelial growth factor receptor signaling pathway', 'neuromuscular junction development', 'neuron projection development', 'positive regulation of nucleocytoplasmic transport', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein catabolic process', 'progesterone receptor signaling pathway', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein K63-linked ubiquitination', 'protein polyubiquitination', 'protein targeting to lysosome', 'protein ubiquitination', 'receptor catabolic process', 'receptor internalization', 'regulation of dendrite morphogenesis', 'regulation of ion transmembrane transport', 'regulation of macroautophagy', 'regulation of membrane potential', 'regulation of potassium ion transmembrane transporter activity', 'regulation of synapse organization', 'response to calcium ion', 'ubiquitin-dependent protein catabolic process', 'ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway', 'viral budding']['energy homeostasis', 'fat pad development', 'female gonad development', 'female meiosis I', 'hypothalamus gonadotrophin-releasing hormone neuron development', 'male meiosis I', 'mitochondrion transport along microtubule', 'modification-dependent protein catabolic process', 'neuron projection morphogenesis', 'positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'positive regulation of protein monoubiquitination', 'protein ubiquitination', 'regulation of mitochondrial membrane potential', 'regulation of neuron death', 'regulation of proteasomal protein catabolic process', 'seminiferous tubule development']
MAP/microtubule affinity-regulating kinase 3
213
MAP/microtubule affinity-regulating kinase 3
213
2.0
70
0.7
P27448P27448['intracellular signal transduction', 'microtubule cytoskeleton organization', 'negative regulation of hippo signaling', 'peptidyl-serine autophosphorylation', 'peptidyl-serine phosphorylation', 'positive regulation of protein binding', 'protein phosphorylation']['intracellular signal transduction', 'microtubule cytoskeleton organization', 'negative regulation of hippo signaling', 'peptidyl-serine autophosphorylation', 'peptidyl-serine phosphorylation', 'positive regulation of protein binding', 'protein phosphorylation']
14-3-3 protein gamma
194
E3 ubiquitin-protein ligase NEDD4-like
341
9.6
nan
nan
P61981Q96PU5['cellular response to insulin stimulus', 'negative regulation of protein kinase activity', 'protein localization', 'protein targeting', 'regulation of neuron differentiation', 'regulation of signal transduction', 'regulation of synaptic plasticity', 'signal transduction']['cell differentiation', 'ion transmembrane transport', 'negative regulation of potassium ion transmembrane transport', 'negative regulation of potassium ion transmembrane transporter activity', 'negative regulation of protein localization to cell surface', 'negative regulation of sodium ion transmembrane transport', 'negative regulation of sodium ion transmembrane transporter activity', 'positive regulation of caveolin-mediated endocytosis', 'positive regulation of dendrite extension', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein K48-linked ubiquitination', 'protein polyubiquitination', 'protein ubiquitination', 'regulation of dendrite morphogenesis', 'regulation of ion transmembrane transport', 'regulation of membrane depolarization', 'regulation of membrane potential', 'regulation of membrane repolarization', 'regulation of potassium ion transmembrane transporter activity', 'regulation of protein stability', 'regulation of sodium ion transmembrane transport', 'ubiquitin-dependent protein catabolic process', 'ventricular cardiac muscle cell action potential']
Epididymis luminal protein 214
243
Uncharacterized protein
236
2.1
nan
nan
V9HW68Q7Z3Y4[][]
Coagulation factor VII
238
Pancreatic trypsin inhibitor
49
9.4
100
0.11
P08709P00974['activation of blood coagulation via clotting cascade', 'animal organ regeneration', 'blood coagulation', 'blood coagulation, extrinsic pathway', 'blood coagulation, fibrin clot formation', 'blood coagulation, intrinsic pathway', 'circadian rhythm', 'positive regulation of blood coagulation', 'positive regulation of cell migration', 'positive regulation of leukocyte chemotaxis', 'positive regulation of platelet-derived growth factor receptor signaling pathway', 'positive regulation of positive chemotaxis', 'positive regulation of protein kinase B signaling', 'protein processing', 'proteolysis', 'response to 2,3,7,8-tetrachlorodibenzodioxine', 'response to anticoagulant', 'response to astaxanthin', 'response to carbon dioxide', 'response to cholesterol', 'response to estradiol', 'response to estrogen', 'response to genistein', 'response to growth hormone', 'response to hypoxia', 'response to Thyroid stimulating hormone', 'response to thyrotropin-releasing hormone', 'response to thyroxine', 'response to vitamin K', 'response to wounding', 'zymogen activation']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Protein farnesyltransferase subunit beta
299
GTPase KRas
186
4.0
73
0.34
Q02293P01116['lipid metabolic process', 'negative regulation of cell population proliferation', 'positive regulation of cell cycle', 'positive regulation of cell population proliferation', 'positive regulation of fibroblast proliferation', 'positive regulation of nitric-oxide synthase biosynthetic process', 'protein farnesylation', 'protein prenylation', 'regulation of fibroblast proliferation', 'response to cytokine', 'response to inorganic substance', 'response to organic cyclic compound', 'wound healing']['actin cytoskeleton organization', 'endocrine signaling', 'epithelial tube branching involved in lung morphogenesis', 'forebrain astrocyte development', 'glial cell proliferation', 'homeostasis of number of cells within a tissue', 'MAPK cascade', 'negative regulation of epithelial cell differentiation', 'negative regulation of neuron apoptotic process', 'neuron apoptotic process', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of glial cell proliferation', 'positive regulation of protein phosphorylation', 'positive regulation of Rac protein signal transduction', 'Rac protein signal transduction', 'Ras protein signal transduction', 'regulation of long-term neuronal synaptic plasticity', 'regulation of protein stability', 'regulation of synaptic transmission, GABAergic', 'skeletal muscle cell differentiation', 'striated muscle cell differentiation', 'type I pneumocyte differentiation', 'visual learning']
Complement factor H
1218
Complement factor H
1218
9.9
44
0.23
P08603P08603['complement activation', 'complement activation, alternative pathway', 'proteolysis', 'regulation of complement activation', 'regulation of complement activation, alternative pathway', 'regulation of complement-dependent cytotoxicity']['complement activation', 'complement activation, alternative pathway', 'proteolysis', 'regulation of complement activation', 'regulation of complement activation, alternative pathway', 'regulation of complement-dependent cytotoxicity']
Interleukin-4
151
Cytokine receptor common subunit gamma
182
9.4
nan
nan
D4HNR6P31785['B cell activation', 'immune response']['CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation', 'cytokine-mediated signaling pathway', 'gene expression', 'immune response', 'interleukin-15-mediated signaling pathway', 'interleukin-2-mediated signaling pathway', 'interleukin-4-mediated signaling pathway', 'interleukin-7-mediated signaling pathway', 'mature B cell differentiation', 'positive regulation of B cell differentiation', 'positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation', 'positive regulation of gene expression', 'positive regulation of phagocytosis', 'positive regulation of T cell differentiation in thymus', 'signal transduction', 'T cell differentiation in thymus']
Immunoglobulin kappa constant
107
IGH@ protein
238
2.0
nan
nan
P01834Q6GMX6['adaptive immune response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'retina homeostasis'][]
Hepatocyte growth factor
207
Hepatocyte growth factor
207
4.5
58
0.39
Q08048Q08048['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'proteolysis', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'proteolysis', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']
Chitotriosidase-1
462
Chitotriosidase-1
420
9.6
65
0.16
Q13231Q13231['chitin catabolic process', 'immune response', 'polysaccharide catabolic process', 'polysaccharide digestion', 'response to bacterium']['chitin catabolic process', 'immune response', 'polysaccharide catabolic process', 'polysaccharide digestion', 'response to bacterium']
PDZ and LIM domain protein 4
72
PDZ and LIM domain protein 4
72
2.1
nan
nan
P50479P50479['actin cytoskeleton organization', 'actin cytoskeleton reorganization', 'excitatory chemical synaptic transmission', 'heart development', 'muscle structure development']['actin cytoskeleton organization', 'actin cytoskeleton reorganization', 'excitatory chemical synaptic transmission', 'heart development', 'muscle structure development']
Coagulation factor VII
254
Pancreatic trypsin inhibitor
49
8.7
101
0.11
P08709P00974['activation of blood coagulation via clotting cascade', 'animal organ regeneration', 'blood coagulation', 'blood coagulation, extrinsic pathway', 'blood coagulation, fibrin clot formation', 'blood coagulation, intrinsic pathway', 'circadian rhythm', 'positive regulation of blood coagulation', 'positive regulation of cell migration', 'positive regulation of leukocyte chemotaxis', 'positive regulation of platelet-derived growth factor receptor signaling pathway', 'positive regulation of positive chemotaxis', 'positive regulation of protein kinase B signaling', 'protein processing', 'proteolysis', 'response to 2,3,7,8-tetrachlorodibenzodioxine', 'response to anticoagulant', 'response to astaxanthin', 'response to carbon dioxide', 'response to cholesterol', 'response to estradiol', 'response to estrogen', 'response to genistein', 'response to growth hormone', 'response to hypoxia', 'response to Thyroid stimulating hormone', 'response to thyrotropin-releasing hormone', 'response to thyroxine', 'response to vitamin K', 'response to wounding', 'zymogen activation']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Sodium/calcium exchanger 1
517
Sodium/calcium exchanger 1
517
2.7
81
0.46
P23685P23685['calcium ion import', 'calcium ion import across plasma membrane', 'calcium ion transmembrane transport', 'cell communication', 'cellular sodium ion homeostasis', 'metal ion transport', 'positive regulation of bone mineralization', 'positive regulation of the force of heart contraction', 'response to muscle stretch', 'sodium ion import across plasma membrane', 'sodium ion transmembrane transport']['calcium ion import', 'calcium ion import across plasma membrane', 'calcium ion transmembrane transport', 'cell communication', 'cellular sodium ion homeostasis', 'metal ion transport', 'positive regulation of bone mineralization', 'positive regulation of the force of heart contraction', 'response to muscle stretch', 'sodium ion import across plasma membrane', 'sodium ion transmembrane transport']
Neutrophil defensin 3
83
Neutrophil defensin 3
66
9.6
nan
nan
P59666P59666['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to virus', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing of cells of another organism', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to virus', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing of cells of another organism', 'membrane disruption in another organism']
Aldo-keto reductase family 1 member C21
5
Aldo-keto reductase family 1 member C21
5
8.8
63
0.18
Q91WR5Q91WR5['daunorubicin metabolic process', 'doxorubicin metabolic process', 'progesterone metabolic process', 'prostaglandin metabolic process', 'steroid biosynthetic process', 'steroid metabolic process']['daunorubicin metabolic process', 'doxorubicin metabolic process', 'progesterone metabolic process', 'prostaglandin metabolic process', 'steroid biosynthetic process', 'steroid metabolic process']
Amyloid-beta precursor protein
291
Amyloid-beta precursor protein
341
2.0
55
0.89
P05067P05067['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Inhibitor of nuclear factor kappa-B kinase subunit alpha
658
Inhibitor of nuclear factor kappa-B kinase subunit alpha
658
8.3
46
0.26
O15111O15111['anatomical structure morphogenesis', 'cellular response to cadmium ion', 'cellular response to reactive oxygen species', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'I-kappaB kinase/NF-kappaB signaling', 'I-kappaB phosphorylation', 'immune response', 'inflammatory response', 'innate immune response', 'negative regulation of NF-kappaB transcription factor activity', 'NIK/NF-kappaB signaling', 'peptidyl-serine phosphorylation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interferon-alpha production', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein phosphorylation', 'response to virus', 'tumor necrosis factor-mediated signaling pathway']['anatomical structure morphogenesis', 'cellular response to cadmium ion', 'cellular response to reactive oxygen species', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'I-kappaB kinase/NF-kappaB signaling', 'I-kappaB phosphorylation', 'immune response', 'inflammatory response', 'innate immune response', 'negative regulation of NF-kappaB transcription factor activity', 'NIK/NF-kappaB signaling', 'peptidyl-serine phosphorylation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interferon-alpha production', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein phosphorylation', 'response to virus', 'tumor necrosis factor-mediated signaling pathway']
Defensin alpha 4
65
Defensin alpha 4
67
7.7
67
0.19
P12838P12838['antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'antimicrobial humoral response', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism', 'T cell chemotaxis']['antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'antimicrobial humoral response', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism', 'T cell chemotaxis']
Ral guanine nucleotide dissociation stimulator
780
Ral guanine nucleotide dissociation stimulator
780
5.4
60
0.31
Q03386Q03386['positive regulation of GTPase activity', 'Ras protein signal transduction', 'small GTPase mediated signal transduction']['positive regulation of GTPase activity', 'Ras protein signal transduction', 'small GTPase mediated signal transduction']
Neutrophil defensin 3
68
Neutrophil defensin 3
68
4.0
64
0.39
P59666P59666['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to virus', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing of cells of another organism', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to virus', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing of cells of another organism', 'membrane disruption in another organism']
Fibrinogen alpha chain
47
Fibrinogen alpha chain
47
2.0
48
1.02
P02671P02671['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']
IGH@ protein
238
IGL@ protein
235
2.0
nan
nan
Q6GMX6Q6IPQ0[][]
Protein FEV
135
Protein FEV
135
3.0
53
0.64
Q99581Q99581['cell differentiation', 'neuron fate specification', 'neuron maturation', 'positive regulation of gene expression', 'regulation of transcription by RNA polymerase II']['cell differentiation', 'neuron fate specification', 'neuron maturation', 'positive regulation of gene expression', 'regulation of transcription by RNA polymerase II']
Protein disulfide-isomerase A6
55
Peroxiredoxin-4
248
2.1
50
0.97
Q15084O08807['protein folding', 'response to endoplasmic reticulum stress']['cell redox homeostasis', 'extracellular matrix organization', 'male gonad development', 'negative regulation of male germ cell proliferation', 'peptidyl-proline hydroxylation to 4-hydroxy-L-proline', 'protein maturation by protein folding', 'reactive oxygen species metabolic process', 'response to oxidative stress', 'spermatogenesis']
ATPase WRNIP1
20
ATPase WRNIP1
39
9.1
45
0.24
Q96S55Q96S55['DNA synthesis involved in DNA repair', 'DNA-templated DNA replication', 'innate immune response', 'regulation of DNA repair', 'regulation of DNA-templated DNA replication initiation']['DNA synthesis involved in DNA repair', 'DNA-templated DNA replication', 'innate immune response', 'regulation of DNA repair', 'regulation of DNA-templated DNA replication initiation']
Trypsin-3
105
Tissue factor pathway inhibitor
267
8.6
95
0.12
P35030P10646['antimicrobial humoral response', 'digestion', 'endothelial cell migration', 'proteolysis', 'zymogen activation']['blood coagulation', 'cellular response to steroid hormone stimulus', 'negative regulation of blood coagulation']
Neuropilin-1
275
Neuropilin-1
275
8.7
72
0.16
O14786O14786['actin cytoskeleton reorganization', 'angiogenesis', 'angiogenesis involved in coronary vascular morphogenesis', 'animal organ morphogenesis', 'artery morphogenesis', 'axon extension involved in axon guidance', 'axon guidance', 'axonal fasciculation', 'axonogenesis involved in innervation', 'basal dendrite arborization', 'basal dendrite development', 'branching involved in blood vessel morphogenesis', 'branchiomotor neuron axon guidance', 'cell migration involved in sprouting angiogenesis', 'cell-cell signaling', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to vascular endothelial growth factor stimulus', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'dichotomous subdivision of terminal units involved in salivary gland branching', 'dorsal root ganglion morphogenesis', 'endothelial cell chemotaxis', 'endothelial cell migration', 'endothelial tip cell fate specification', 'facial nerve structural organization', 'facioacoustic ganglion development', 'gonadotrophin-releasing hormone neuronal migration to the hypothalamus', 'hepatocyte growth factor receptor signaling pathway', 'integrin-mediated signaling pathway', 'motor neuron migration', 'negative regulation of axon extension involved in axon guidance', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of neuron apoptotic process', 'nerve development', 'neural crest cell migration', 'neural crest cell migration involved in autonomic nervous system development', 'neuron migration', 'neuropilin signaling pathway', 'otic placode development', 'outflow tract septum morphogenesis', 'platelet-derived growth factor receptor signaling pathway', 'positive chemotaxis', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cytokine activity', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of filopodium assembly', 'positive regulation of focal adhesion assembly', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of smooth muscle cell migration', 'positive regulation of stress fiber assembly', 'positive regulation of substrate adhesion-dependent cell spreading', 'postsynapse organization', 'protein localization to early endosome', 'regulation of Cdc42 protein signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of vesicle-mediated transport', 'renal artery morphogenesis', 'response to wounding', 'retina vasculature morphogenesis in camera-type eye', 'retinal ganglion cell axon guidance', 'semaphorin-plexin signaling pathway', 'semaphorin-plexin signaling pathway involved in axon guidance', 'semaphorin-plexin signaling pathway involved in neuron projection guidance', 'sensory neuron axon guidance', 'signal transduction', 'sprouting angiogenesis', 'substrate adhesion-dependent cell spreading', 'substrate-dependent cell migration, cell extension', 'sympathetic ganglion development', 'sympathetic neuron projection extension', 'sympathetic neuron projection guidance', 'toxin transport', 'trigeminal ganglion development', 'trigeminal nerve structural organization', 'vascular endothelial growth factor receptor signaling pathway', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway', 'VEGF-activated neuropilin signaling pathway involved in axon guidance', 'ventral trunk neural crest cell migration', 'vestibulocochlear nerve structural organization', 'viral entry into host cell']['actin cytoskeleton reorganization', 'angiogenesis', 'angiogenesis involved in coronary vascular morphogenesis', 'animal organ morphogenesis', 'artery morphogenesis', 'axon extension involved in axon guidance', 'axon guidance', 'axonal fasciculation', 'axonogenesis involved in innervation', 'basal dendrite arborization', 'basal dendrite development', 'branching involved in blood vessel morphogenesis', 'branchiomotor neuron axon guidance', 'cell migration involved in sprouting angiogenesis', 'cell-cell signaling', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to vascular endothelial growth factor stimulus', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'dichotomous subdivision of terminal units involved in salivary gland branching', 'dorsal root ganglion morphogenesis', 'endothelial cell chemotaxis', 'endothelial cell migration', 'endothelial tip cell fate specification', 'facial nerve structural organization', 'facioacoustic ganglion development', 'gonadotrophin-releasing hormone neuronal migration to the hypothalamus', 'hepatocyte growth factor receptor signaling pathway', 'integrin-mediated signaling pathway', 'motor neuron migration', 'negative regulation of axon extension involved in axon guidance', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of neuron apoptotic process', 'nerve development', 'neural crest cell migration', 'neural crest cell migration involved in autonomic nervous system development', 'neuron migration', 'neuropilin signaling pathway', 'otic placode development', 'outflow tract septum morphogenesis', 'platelet-derived growth factor receptor signaling pathway', 'positive chemotaxis', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cytokine activity', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of filopodium assembly', 'positive regulation of focal adhesion assembly', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of smooth muscle cell migration', 'positive regulation of stress fiber assembly', 'positive regulation of substrate adhesion-dependent cell spreading', 'postsynapse organization', 'protein localization to early endosome', 'regulation of Cdc42 protein signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of vesicle-mediated transport', 'renal artery morphogenesis', 'response to wounding', 'retina vasculature morphogenesis in camera-type eye', 'retinal ganglion cell axon guidance', 'semaphorin-plexin signaling pathway', 'semaphorin-plexin signaling pathway involved in axon guidance', 'semaphorin-plexin signaling pathway involved in neuron projection guidance', 'sensory neuron axon guidance', 'signal transduction', 'sprouting angiogenesis', 'substrate adhesion-dependent cell spreading', 'substrate-dependent cell migration, cell extension', 'sympathetic ganglion development', 'sympathetic neuron projection extension', 'sympathetic neuron projection guidance', 'toxin transport', 'trigeminal ganglion development', 'trigeminal nerve structural organization', 'vascular endothelial growth factor receptor signaling pathway', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway', 'VEGF-activated neuropilin signaling pathway involved in axon guidance', 'ventral trunk neural crest cell migration', 'vestibulocochlear nerve structural organization', 'viral entry into host cell']
Histone-lysine N-methyltransferase SETD7
119
Histone-lysine N-methyltransferase SETD7
119
3.6
74
0.38
Q8WTS6Q8WTS6['cellular response to DNA damage stimulus', 'chromatin organization', 'heterochromatin organization', 'histone lysine methylation', 'peptidyl-lysine dimethylation', 'peptidyl-lysine monomethylation', 'regulation of histone H3-K9 methylation', 'regulation of transcription, DNA-templated']['cellular response to DNA damage stimulus', 'chromatin organization', 'heterochromatin organization', 'histone lysine methylation', 'peptidyl-lysine dimethylation', 'peptidyl-lysine monomethylation', 'regulation of histone H3-K9 methylation', 'regulation of transcription, DNA-templated']
T-cell surface glycoprotein CD3 epsilon chain
122
T-cell surface glycoprotein CD3 delta chain
93
2.0
40
1.23
P07766P04234['adaptive immune response', 'alpha-beta T cell activation', 'apoptotic signaling pathway', 'calcium-mediated signaling', 'CD4-positive, alpha-beta T cell proliferation', 'cell surface receptor signaling pathway', 'cerebellum development', 'dendrite development', 'G protein-coupled receptor signaling pathway', 'gamma-delta T cell activation', 'negative regulation of gene expression', 'negative regulation of smoothened signaling pathway', 'negative thymic T cell selection', 'peptidyl-tyrosine phosphorylation', 'positive regulation of calcium-mediated signaling', 'positive regulation of CD4-positive, alpha-beta T cell proliferation', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cell-matrix adhesion', 'positive regulation of gene expression', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-2 production', 'positive regulation of interleukin-4 production', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of T cell anergy', 'positive regulation of T cell proliferation', 'positive thymic T cell selection', 'protein-containing complex assembly', 'regulation of apoptotic process', 'signal complex assembly', 'smoothened signaling pathway', 'T cell activation', 'T cell anergy', 'T cell costimulation', 'T cell receptor signaling pathway', 'transmembrane receptor protein tyrosine kinase signaling pathway']['adaptive immune response', 'alpha-beta T cell activation', 'cell surface receptor signaling pathway', 'positive thymic T cell selection', 'T cell receptor signaling pathway']
Lectin-related NK cell receptor LY49L4
107
Lectin-related NK cell receptor LY49L4
107
2.1
36
1.33
Q9JIP9Q9JIP9[][]
Trypsin-3
253
Tissue factor pathway inhibitor
267
9.9
103
0.1
P35030P10646['antimicrobial humoral response', 'digestion', 'endothelial cell migration', 'proteolysis', 'zymogen activation']['blood coagulation', 'cellular response to steroid hormone stimulus', 'negative regulation of blood coagulation']
Histone-lysine N-methyltransferase 2C
1057
Histone-lysine N-methyltransferase 2C
1057
4.1
66
0.37
Q8NEZ4Q8NEZ4['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']
Ribosomal protein S6 kinase alpha-1
575
Ribosomal protein S6 kinase alpha-1
575
2.0
49
1.02
Q15418Q15418['cell cycle', 'chemical synaptic transmission', 'hepatocyte proliferation', 'intracellular signal transduction', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'peptidyl-serine phosphorylation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of hepatic stellate cell activation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of DNA-templated transcription in response to stress', 'regulation of translation in response to stress', 'signal transduction']['cell cycle', 'chemical synaptic transmission', 'hepatocyte proliferation', 'intracellular signal transduction', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'peptidyl-serine phosphorylation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of hepatic stellate cell activation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of DNA-templated transcription in response to stress', 'regulation of translation in response to stress', 'signal transduction']
Secreted frizzled-related protein 3
35
Secreted frizzled-related protein 3
35
9.5
52
0.2
P97401P97401['canonical Wnt signaling pathway', 'cochlea morphogenesis', 'convergent extension involved in organogenesis', 'epithelial cell development', 'hepatocyte differentiation', 'inner ear morphogenesis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cartilage development', 'negative regulation of cell development', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of hepatocyte differentiation', 'negative regulation of Wnt signaling pathway', 'neural crest cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of fat cell differentiation', 'somite development']['canonical Wnt signaling pathway', 'cochlea morphogenesis', 'convergent extension involved in organogenesis', 'epithelial cell development', 'hepatocyte differentiation', 'inner ear morphogenesis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cartilage development', 'negative regulation of cell development', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of hepatocyte differentiation', 'negative regulation of Wnt signaling pathway', 'neural crest cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of fat cell differentiation', 'somite development']
Histone-lysine N-methyltransferase 2C
1136
Histone-lysine N-methyltransferase 2C
1136
9.5
39
0.27
Q8NEZ4Q8NEZ4['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']
Protein capicua homolog
270
Protein capicua homolog
270
2.0
33
1.49
Q96RK0Q96RK0['brain development', 'learning', 'memory', 'negative regulation of transcription, DNA-templated', 'regulation of transcription by RNA polymerase II', 'social behavior']['brain development', 'learning', 'memory', 'negative regulation of transcription, DNA-templated', 'regulation of transcription by RNA polymerase II', 'social behavior']
Oxidized low-density lipoprotein receptor 1
140
Oxidized low-density lipoprotein receptor 1
140
2.0
nan
nan
P78380P78380['blood circulation', 'cell death', 'immune system process', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipoprotein metabolic process', 'proteolysis']['blood circulation', 'cell death', 'immune system process', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipoprotein metabolic process', 'proteolysis']
Protection of telomeres protein 1
621
Adrenocortical dysplasia protein homolog
228
9.7
60
0.17
Q9NUX5Q96AP0['DNA duplex unwinding', 'establishment of protein localization to telomere', 'negative regulation of telomerase activity', 'negative regulation of telomere maintenance via telomerase', 'positive regulation of DNA helicase activity', 'positive regulation of DNA strand elongation', 'positive regulation of helicase activity', 'positive regulation of telomerase activity', 'positive regulation of telomere maintenance', 'positive regulation of telomere maintenance via telomerase', 'regulation of DNA helicase activity', 'regulation of double-strand break repair via nonhomologous end joining', 'regulation of telomere maintenance via telomerase', 'telomere assembly', 'telomere capping', 'telomere maintenance via telomerase', 'telomeric D-loop disassembly']['embryonic limb morphogenesis', 'establishment of protein localization to telomere', 'intracellular protein transport', 'negative regulation of telomere maintenance via telomerase', 'positive regulation of single-stranded telomeric DNA binding', 'positive regulation of telomerase activity', 'positive regulation of telomere maintenance', 'positive regulation of telomere maintenance via telomerase', 'protection from non-homologous end joining at telomere', 'protein localization to chromosome, telomeric region', 'segmentation', 'skeletal system development', 'telomere assembly', 'telomere capping', 'telomere maintenance', 'telomere maintenance via telomerase', 'urogenital system development']
Amyloid-beta precursor protein
144
Amyloid-beta precursor protein
133
5.3
73
0.26
P05067P05067['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Uncharacterized protein
245
Uncharacterized protein
239
2.0
nan
nan
Q6N089Q8TCD0[][]
Protein farnesyltransferase subunit beta
366
GTPase KRas
186
9.8
76
0.13
Q02293P01118['lipid metabolic process', 'negative regulation of cell population proliferation', 'positive regulation of cell cycle', 'positive regulation of cell population proliferation', 'positive regulation of fibroblast proliferation', 'positive regulation of nitric-oxide synthase biosynthetic process', 'protein farnesylation', 'protein prenylation', 'regulation of fibroblast proliferation', 'response to cytokine', 'response to inorganic substance', 'response to organic cyclic compound', 'wound healing']['actin cytoskeleton organization', 'endocrine signaling', 'epithelial tube branching involved in lung morphogenesis', 'forebrain astrocyte development', 'glial cell proliferation', 'homeostasis of number of cells within a tissue', 'MAPK cascade', 'negative regulation of epithelial cell differentiation', 'negative regulation of neuron apoptotic process', 'neuron apoptotic process', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of glial cell proliferation', 'positive regulation of protein phosphorylation', 'positive regulation of Rac protein signal transduction', 'Rac protein signal transduction', 'Ras protein signal transduction', 'regulation of long-term neuronal synaptic plasticity', 'regulation of protein stability', 'regulation of synaptic transmission, GABAergic', 'skeletal muscle cell differentiation', 'striated muscle cell differentiation', 'type I pneumocyte differentiation', 'visual learning']
Prothrombin
594
Prothrombin
594
9.8
nan
nan
P00734P00734['acute-phase response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'blood coagulation', 'blood coagulation, common pathway', 'cell surface receptor signaling pathway', 'cytolysis by host of symbiont cells', 'fibrinolysis', 'negative regulation of astrocyte differentiation', 'negative regulation of blood coagulation', 'negative regulation of cytokine production involved in inflammatory response', 'negative regulation of fibrinolysis', 'negative regulation of platelet activation', 'negative regulation of proteolysis', 'neutrophil-mediated killing of gram-negative bacterium', 'platelet activation', 'positive regulation of blood coagulation', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of lipid kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to nucleus', 'positive regulation of protein phosphorylation', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of release of sequestered calcium ion into cytosol', 'proteolysis', 'regulation of blood coagulation', 'regulation of cell shape', 'regulation of cytosolic calcium ion concentration', 'response to wounding', 'zymogen activation']['acute-phase response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'blood coagulation', 'blood coagulation, common pathway', 'cell surface receptor signaling pathway', 'cytolysis by host of symbiont cells', 'fibrinolysis', 'negative regulation of astrocyte differentiation', 'negative regulation of blood coagulation', 'negative regulation of cytokine production involved in inflammatory response', 'negative regulation of fibrinolysis', 'negative regulation of platelet activation', 'negative regulation of proteolysis', 'neutrophil-mediated killing of gram-negative bacterium', 'platelet activation', 'positive regulation of blood coagulation', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of lipid kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to nucleus', 'positive regulation of protein phosphorylation', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of release of sequestered calcium ion into cytosol', 'proteolysis', 'regulation of blood coagulation', 'regulation of cell shape', 'regulation of cytosolic calcium ion concentration', 'response to wounding', 'zymogen activation']
Immunoglobulin gamma-1 heavy chain
228
Immunoglobulin gamma-1 heavy chain
228
2.0
nan
nan
P0DOX5P0DOX5['adaptive immune response']['adaptive immune response']
Tumor suppressor candidate 3
99
Protein cereblon
234
2.0
49
1.0
Q13454Q96SW2['cognition', 'magnesium ion transport', 'protein N-linked glycosylation', 'protein N-linked glycosylation via asparagine', 'transmembrane transport']['locomotory exploration behavior', 'negative regulation of large conductance calcium-activated potassium channel activity', 'negative regulation of protein-containing complex assembly', 'positive regulation of protein-containing complex assembly', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination']
E3 ubiquitin-protein ligase RNF31
885
E3 ubiquitin-protein ligase RNF31
898
9.9
nan
nan
Q96EP0Q96EP0['CD40 signaling pathway', 'defense response to bacterium', 'negative regulation of necroptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of xenophagy', 'protein linear polyubiquitination', 'protein polyubiquitination', 'T cell receptor signaling pathway']['CD40 signaling pathway', 'defense response to bacterium', 'negative regulation of necroptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of xenophagy', 'protein linear polyubiquitination', 'protein polyubiquitination', 'T cell receptor signaling pathway']
C-C chemokine receptor type 5
20
C-C motif chemokine 5
33
7.1
73
0.19
P51681P13501['calcium ion transport', 'calcium-mediated signaling', 'cell chemotaxis', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular defense response', 'cellular response to lipopolysaccharide', 'chemotaxis', 'dendritic cell chemotaxis', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'MAPK cascade', 'positive regulation of cytosolic calcium ion concentration', 'release of sequestered calcium ion into cytosol by sarcoplasmic reticulum', 'response to cholesterol', 'signaling']['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'chemokine-mediated signaling pathway', 'chemotaxis', 'dendritic cell chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of innate immune response', 'positive regulation of macrophage chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of translational initiation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of viral genome replication', 'protein kinase B signaling', 'regulation of chronic inflammatory response', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to toxic substance', 'response to virus']
Hepatocyte growth factor activator
521
Hepatocyte growth factor activator
394
2.0
61
0.81
Q04756Q04756['blood coagulation', 'proteolysis', 'zymogen activation']['blood coagulation', 'proteolysis', 'zymogen activation']
Kappa-type opioid receptor
345
Kappa-type opioid receptor
345
8.0
50
0.25
P41145P41145['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting opioid receptor signaling pathway', 'behavioral response to cocaine', 'cellular response to glucose stimulus', 'cellular response to lipopolysaccharide', 'chemical synaptic transmission', 'conditioned place preference', 'defense response to virus', 'eating behavior', 'estrous cycle', 'G protein-coupled opioid receptor signaling pathway', 'immune response', 'locomotory behavior', 'maternal behavior', 'negative regulation of luteinizing hormone secretion', 'neuropeptide signaling pathway', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of dopamine secretion', 'positive regulation of eating behavior', 'positive regulation of locomotion', 'positive regulation of p38MAPK cascade', 'positive regulation of potassium ion transmembrane transport', 'regulation of saliva secretion', 'regulation of sensory perception of pain', 'response to acrylamide', 'response to estrogen', 'response to ethanol', 'response to insulin', 'response to morphine', 'response to radiation', 'sensory perception', 'sensory perception of pain', 'sensory perception of temperature stimulus']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting opioid receptor signaling pathway', 'behavioral response to cocaine', 'cellular response to glucose stimulus', 'cellular response to lipopolysaccharide', 'chemical synaptic transmission', 'conditioned place preference', 'defense response to virus', 'eating behavior', 'estrous cycle', 'G protein-coupled opioid receptor signaling pathway', 'immune response', 'locomotory behavior', 'maternal behavior', 'negative regulation of luteinizing hormone secretion', 'neuropeptide signaling pathway', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of dopamine secretion', 'positive regulation of eating behavior', 'positive regulation of locomotion', 'positive regulation of p38MAPK cascade', 'positive regulation of potassium ion transmembrane transport', 'regulation of saliva secretion', 'regulation of sensory perception of pain', 'response to acrylamide', 'response to estrogen', 'response to ethanol', 'response to insulin', 'response to morphine', 'response to radiation', 'sensory perception', 'sensory perception of pain', 'sensory perception of temperature stimulus']
Immunoglobulin lambda constant 1
105
Immunoglobulin heavy constant gamma 1
103
2.1
nan
nan
P01842P01857['adaptive immune response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response', 'antibody-dependent cellular cytotoxicity', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'complement-dependent cytotoxicity', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
Cytotoxic T-lymphocyte protein 4
157
Cytotoxic T-lymphocyte protein 4
157
2.0
29
1.69
P16410P16410['adaptive immune response', 'B cell receptor signaling pathway', 'cellular response to DNA damage stimulus', 'immune response', 'negative regulation of B cell proliferation', 'negative regulation of immune response', 'negative regulation of regulatory T cell differentiation', 'negative regulation of T cell proliferation', 'positive regulation of apoptotic process', 'T cell receptor signaling pathway']['adaptive immune response', 'B cell receptor signaling pathway', 'cellular response to DNA damage stimulus', 'immune response', 'negative regulation of B cell proliferation', 'negative regulation of immune response', 'negative regulation of regulatory T cell differentiation', 'negative regulation of T cell proliferation', 'positive regulation of apoptotic process', 'T cell receptor signaling pathway']
Baculoviral IAP repeat-containing protein 3
28
Baculoviral IAP repeat-containing protein 3
28
2.3
59
0.73
Q13489Q13489['cell surface receptor signaling pathway', 'I-kappaB kinase/NF-kappaB signaling', 'negative regulation of apoptotic process', 'negative regulation of necroptotic process', 'NIK/NF-kappaB signaling', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of protein ubiquitination', 'regulation of apoptotic process', 'regulation of cell cycle', 'regulation of cysteine-type endopeptidase activity', 'regulation of inflammatory response', 'regulation of innate immune response', 'regulation of necroptotic process', 'regulation of nucleotide-binding oligomerization domain containing signaling pathway', 'regulation of RIG-I signaling pathway', 'regulation of toll-like receptor signaling pathway', 'spermatogenesis', 'tumor necrosis factor-mediated signaling pathway']['cell surface receptor signaling pathway', 'I-kappaB kinase/NF-kappaB signaling', 'negative regulation of apoptotic process', 'negative regulation of necroptotic process', 'NIK/NF-kappaB signaling', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of protein ubiquitination', 'regulation of apoptotic process', 'regulation of cell cycle', 'regulation of cysteine-type endopeptidase activity', 'regulation of inflammatory response', 'regulation of innate immune response', 'regulation of necroptotic process', 'regulation of nucleotide-binding oligomerization domain containing signaling pathway', 'regulation of RIG-I signaling pathway', 'regulation of toll-like receptor signaling pathway', 'spermatogenesis', 'tumor necrosis factor-mediated signaling pathway']
Membrane primary amine oxidase
41
Membrane primary amine oxidase
41
9.6
55
0.19
Q16853Q16853['amine metabolic process', 'cell adhesion', 'inflammatory response', 'negative regulation of primary amine oxidase activity', 'response to antibiotic']['amine metabolic process', 'cell adhesion', 'inflammatory response', 'negative regulation of primary amine oxidase activity', 'response to antibiotic']
Neurogenic locus notch homolog protein 1
149
Neurogenic locus notch homolog protein 1
206
9.8
77
0.13
P46531P46531['animal organ regeneration', 'aortic valve morphogenesis', 'apoptotic process involved in embryonic digit morphogenesis', 'arterial endothelial cell differentiation', 'astrocyte differentiation', 'atrioventricular node development', 'atrioventricular valve morphogenesis', 'auditory receptor cell fate commitment', 'axon guidance', 'branching morphogenesis of an epithelial tube', 'calcium-ion regulated exocytosis', 'cardiac atrium morphogenesis', 'cardiac chamber formation', 'cardiac epithelial to mesenchymal transition', 'cardiac left ventricle morphogenesis', 'cardiac muscle cell myoblast differentiation', 'cardiac muscle cell proliferation', 'cardiac muscle tissue morphogenesis', 'cardiac right atrium morphogenesis', 'cardiac right ventricle formation', 'cardiac septum morphogenesis', 'cardiac vascular smooth muscle cell development', 'cardiac ventricle morphogenesis', 'cell differentiation in spinal cord', 'cell migration involved in endocardial cushion formation', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to tumor cell', 'cellular response to vascular endothelial growth factor stimulus', 'cilium assembly', 'collecting duct development', 'compartment pattern specification', 'coronary artery morphogenesis', 'coronary sinus valve morphogenesis', 'coronary vein morphogenesis', 'determination of left/right symmetry', 'distal tubule development', 'embryonic hindlimb morphogenesis', 'endocardial cell differentiation', 'endocardial cushion morphogenesis', 'endocardium development', 'endocardium morphogenesis', 'endoderm development', 'epidermal cell fate specification', 'epithelial cell fate commitment', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'epithelial to mesenchymal transition involved in endocardial cushion formation', 'forebrain development', 'foregut morphogenesis', 'glomerular mesangial cell development', 'growth involved in heart morphogenesis', 'hair follicle morphogenesis', 'heart development', 'heart looping', 'heart trabecula morphogenesis', 'homeostasis of number of cells within a tissue', 'humoral immune response', 'immune response', 'in utero embryonic development', 'inflammatory response to antigenic stimulus', 'inhibition of neuroepithelial cell differentiation', 'interleukin-17-mediated signaling pathway', 'keratinocyte differentiation', 'left/right axis specification', 'liver development', 'lung development', 'mesenchymal cell development', 'mitral valve formation', 'negative regulation of anoikis', 'negative regulation of biomineral tissue development', 'negative regulation of BMP signaling pathway', 'negative regulation of calcium ion-dependent exocytosis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of catalytic activity', 'negative regulation of cell adhesion molecule production', 'negative regulation of cell migration involved in sprouting angiogenesis', 'negative regulation of cell population proliferation', 'negative regulation of cell proliferation involved in heart valve morphogenesis', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cell-substrate adhesion', 'negative regulation of cold-induced thermogenesis', 'negative regulation of endothelial cell chemotaxis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix constituent secretion', 'negative regulation of gene expression', 'negative regulation of glial cell proliferation', 'negative regulation of inner ear auditory receptor cell differentiation', 'negative regulation of myoblast differentiation', 'negative regulation of myotube differentiation', 'negative regulation of neurogenesis', 'negative regulation of oligodendrocyte differentiation', 'negative regulation of ossification', 'negative regulation of osteoblast differentiation', 'negative regulation of photoreceptor cell differentiation', 'negative regulation of pro-B cell differentiation', 'negative regulation of stem cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube development', 'neuroendocrine cell differentiation', 'neuronal stem cell population maintenance', 'Notch signaling involved in heart development', 'Notch signaling pathway', 'Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation', 'oligodendrocyte differentiation', 'outflow tract morphogenesis', 'pericardium morphogenesis', 'positive regulation of aorta morphogenesis', 'positive regulation of apoptotic process involved in morphogenesis', 'positive regulation of astrocyte differentiation', 'positive regulation of BMP signaling pathway', 'positive regulation of cardiac epithelial to mesenchymal transition', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell differentiation', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of keratinocyte differentiation', 'positive regulation of neuroblast proliferation', 'positive regulation of Notch signaling pathway', 'positive regulation of Ras protein signal transduction', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription of Notch receptor target', 'positive regulation of transcription, DNA-templated', 'positive regulation of viral genome replication', 'prostate gland epithelium morphogenesis', 'protein catabolic process', 'protein import into nucleus', 'pulmonary valve morphogenesis', 'regulation of epithelial cell proliferation involved in prostate gland development', 'regulation of extracellular matrix assembly', 'regulation of somitogenesis', 'regulation of stem cell proliferation', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to corticosteroid', 'response to lipopolysaccharide', 'response to muramyl dipeptide', 'retinal cone cell differentiation', 'secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development', 'skeletal muscle cell differentiation', 'somatic stem cell division', 'spermatogenesis', 'sprouting angiogenesis', 'T-helper 17 type immune response', 'tissue regeneration', 'transcription by RNA polymerase II', 'tube formation', 'vasculogenesis involved in coronary vascular morphogenesis', 'venous endothelial cell differentiation', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis']['animal organ regeneration', 'aortic valve morphogenesis', 'apoptotic process involved in embryonic digit morphogenesis', 'arterial endothelial cell differentiation', 'astrocyte differentiation', 'atrioventricular node development', 'atrioventricular valve morphogenesis', 'auditory receptor cell fate commitment', 'axon guidance', 'branching morphogenesis of an epithelial tube', 'calcium-ion regulated exocytosis', 'cardiac atrium morphogenesis', 'cardiac chamber formation', 'cardiac epithelial to mesenchymal transition', 'cardiac left ventricle morphogenesis', 'cardiac muscle cell myoblast differentiation', 'cardiac muscle cell proliferation', 'cardiac muscle tissue morphogenesis', 'cardiac right atrium morphogenesis', 'cardiac right ventricle formation', 'cardiac septum morphogenesis', 'cardiac vascular smooth muscle cell development', 'cardiac ventricle morphogenesis', 'cell differentiation in spinal cord', 'cell migration involved in endocardial cushion formation', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to tumor cell', 'cellular response to vascular endothelial growth factor stimulus', 'cilium assembly', 'collecting duct development', 'compartment pattern specification', 'coronary artery morphogenesis', 'coronary sinus valve morphogenesis', 'coronary vein morphogenesis', 'determination of left/right symmetry', 'distal tubule development', 'embryonic hindlimb morphogenesis', 'endocardial cell differentiation', 'endocardial cushion morphogenesis', 'endocardium development', 'endocardium morphogenesis', 'endoderm development', 'epidermal cell fate specification', 'epithelial cell fate commitment', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'epithelial to mesenchymal transition involved in endocardial cushion formation', 'forebrain development', 'foregut morphogenesis', 'glomerular mesangial cell development', 'growth involved in heart morphogenesis', 'hair follicle morphogenesis', 'heart development', 'heart looping', 'heart trabecula morphogenesis', 'homeostasis of number of cells within a tissue', 'humoral immune response', 'immune response', 'in utero embryonic development', 'inflammatory response to antigenic stimulus', 'inhibition of neuroepithelial cell differentiation', 'interleukin-17-mediated signaling pathway', 'keratinocyte differentiation', 'left/right axis specification', 'liver development', 'lung development', 'mesenchymal cell development', 'mitral valve formation', 'negative regulation of anoikis', 'negative regulation of biomineral tissue development', 'negative regulation of BMP signaling pathway', 'negative regulation of calcium ion-dependent exocytosis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of catalytic activity', 'negative regulation of cell adhesion molecule production', 'negative regulation of cell migration involved in sprouting angiogenesis', 'negative regulation of cell population proliferation', 'negative regulation of cell proliferation involved in heart valve morphogenesis', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cell-substrate adhesion', 'negative regulation of cold-induced thermogenesis', 'negative regulation of endothelial cell chemotaxis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix constituent secretion', 'negative regulation of gene expression', 'negative regulation of glial cell proliferation', 'negative regulation of inner ear auditory receptor cell differentiation', 'negative regulation of myoblast differentiation', 'negative regulation of myotube differentiation', 'negative regulation of neurogenesis', 'negative regulation of oligodendrocyte differentiation', 'negative regulation of ossification', 'negative regulation of osteoblast differentiation', 'negative regulation of photoreceptor cell differentiation', 'negative regulation of pro-B cell differentiation', 'negative regulation of stem cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube development', 'neuroendocrine cell differentiation', 'neuronal stem cell population maintenance', 'Notch signaling involved in heart development', 'Notch signaling pathway', 'Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation', 'oligodendrocyte differentiation', 'outflow tract morphogenesis', 'pericardium morphogenesis', 'positive regulation of aorta morphogenesis', 'positive regulation of apoptotic process involved in morphogenesis', 'positive regulation of astrocyte differentiation', 'positive regulation of BMP signaling pathway', 'positive regulation of cardiac epithelial to mesenchymal transition', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell differentiation', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of keratinocyte differentiation', 'positive regulation of neuroblast proliferation', 'positive regulation of Notch signaling pathway', 'positive regulation of Ras protein signal transduction', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription of Notch receptor target', 'positive regulation of transcription, DNA-templated', 'positive regulation of viral genome replication', 'prostate gland epithelium morphogenesis', 'protein catabolic process', 'protein import into nucleus', 'pulmonary valve morphogenesis', 'regulation of epithelial cell proliferation involved in prostate gland development', 'regulation of extracellular matrix assembly', 'regulation of somitogenesis', 'regulation of stem cell proliferation', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to corticosteroid', 'response to lipopolysaccharide', 'response to muramyl dipeptide', 'retinal cone cell differentiation', 'secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development', 'skeletal muscle cell differentiation', 'somatic stem cell division', 'spermatogenesis', 'sprouting angiogenesis', 'T-helper 17 type immune response', 'tissue regeneration', 'transcription by RNA polymerase II', 'tube formation', 'vasculogenesis involved in coronary vascular morphogenesis', 'venous endothelial cell differentiation', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis']
DNA (cytosine-5)-methyltransferase 3A
559
DNA (cytosine-5)-methyltransferase 3A
520
8.9
69
0.16
Q9Y6K1Q9Y6K1['aging', 'C-5 methylation of cytosine', 'cellular response to amino acid stimulus', 'cellular response to bisphenol A', 'cellular response to ethanol', 'cellular response to hypoxia', 'DNA methylation', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'DNA methylation on cytosine', 'DNA methylation-dependent heterochromatin assembly', 'hepatocyte apoptotic process', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron differentiation', 'positive regulation of cell death', 'regulation of gene expression by genomic imprinting', 'response to cocaine', 'response to estradiol', 'response to ionizing radiation', 'response to lead ion', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'spermatogenesis']['aging', 'C-5 methylation of cytosine', 'cellular response to amino acid stimulus', 'cellular response to bisphenol A', 'cellular response to ethanol', 'cellular response to hypoxia', 'DNA methylation', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'DNA methylation on cytosine', 'DNA methylation-dependent heterochromatin assembly', 'hepatocyte apoptotic process', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron differentiation', 'positive regulation of cell death', 'regulation of gene expression by genomic imprinting', 'response to cocaine', 'response to estradiol', 'response to ionizing radiation', 'response to lead ion', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'spermatogenesis']
Low affinity immunoglobulin epsilon Fc receptor
273
Low affinity immunoglobulin epsilon Fc receptor
273
8.9
85
0.13
P06734P06734['positive regulation of humoral immune response mediated by circulating immunoglobulin', 'positive regulation of killing of cells of another organism', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of nitric-oxide synthase biosynthetic process']['positive regulation of humoral immune response mediated by circulating immunoglobulin', 'positive regulation of killing of cells of another organism', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of nitric-oxide synthase biosynthetic process']
Histone-lysine N-methyltransferase 2A
1575
Histone-lysine N-methyltransferase 2A
1572
8.9
51
0.22
Q03164Q03164['anterior/posterior pattern specification', 'apoptotic process', 'chromatin organization', 'circadian regulation of gene expression', 'definitive hemopoiesis', 'DNA methylation', 'embryonic hemopoiesis', 'exploration behavior', 'fibroblast proliferation', 'histone H3-K4 dimethylation', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'histone H3-K4 trimethylation', 'histone H4-K16 acetylation', 'homeostasis of number of cells within a tissue', 'membrane depolarization', 'negative regulation of DNA methylation', 'negative regulation of fibroblast proliferation', 'peptidyl-lysine monomethylation', 'positive regulation of histone H3-K4 methylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of transporter activity', 'post-embryonic development', 'protein-containing complex assembly', 'regulation of histone H3-K14 acetylation', 'regulation of histone H3-K27 acetylation', 'regulation of histone H3-K9 acetylation', 'regulation of short-term neuronal synaptic plasticity', 'response to potassium ion', 'spleen development', 'visual learning']['anterior/posterior pattern specification', 'apoptotic process', 'chromatin organization', 'circadian regulation of gene expression', 'definitive hemopoiesis', 'DNA methylation', 'embryonic hemopoiesis', 'exploration behavior', 'fibroblast proliferation', 'histone H3-K4 dimethylation', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'histone H3-K4 trimethylation', 'histone H4-K16 acetylation', 'homeostasis of number of cells within a tissue', 'membrane depolarization', 'negative regulation of DNA methylation', 'negative regulation of fibroblast proliferation', 'peptidyl-lysine monomethylation', 'positive regulation of histone H3-K4 methylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of transporter activity', 'post-embryonic development', 'protein-containing complex assembly', 'regulation of histone H3-K14 acetylation', 'regulation of histone H3-K27 acetylation', 'regulation of histone H3-K9 acetylation', 'regulation of short-term neuronal synaptic plasticity', 'response to potassium ion', 'spleen development', 'visual learning']
Prostasin
70
Pancreatic trypsin inhibitor
49
9.8
98
0.1
Q16651P00974['positive regulation of sodium ion transport', 'proteolysis']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Neurogenic locus notch homolog protein 3
1488
Neurogenic locus notch homolog protein 3
1488
8.9
89
0.13
Q9UM47Q9UM47['artery morphogenesis', 'axon guidance', 'forebrain development', 'glomerular capillary formation', 'negative regulation of neuron differentiation', 'negative regulation of transcription by RNA polymerase II', 'neuroblast differentiation', 'neuron fate commitment', 'Notch signaling pathway', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II']['artery morphogenesis', 'axon guidance', 'forebrain development', 'glomerular capillary formation', 'negative regulation of neuron differentiation', 'negative regulation of transcription by RNA polymerase II', 'neuroblast differentiation', 'neuron fate commitment', 'Notch signaling pathway', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II']
Platelet basic protein
105
Platelet basic protein
105
8.8
72
0.16
P02775P02775['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'defense response to bacterium', 'glucose transmembrane transport', 'inflammatory response', 'killing of cells of another organism', 'neutrophil chemotaxis', 'positive regulation of cell division']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'defense response to bacterium', 'glucose transmembrane transport', 'inflammatory response', 'killing of cells of another organism', 'neutrophil chemotaxis', 'positive regulation of cell division']
Axin-1
121
Adenomatous polyposis coli protein
2042
8.1
74
0.17
O15169P25054['activation of protein kinase activity', 'apoptotic process', 'axial mesoderm formation', 'canonical Wnt signaling pathway', 'cell development', 'cytoplasmic microtubule organization', 'dorsal/ventral axis specification', 'genomic imprinting', 'head development', 'in utero embryonic development', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of fat cell differentiation', 'negative regulation of protein metabolic process', 'negative regulation of transcription elongation from RNA polymerase II promoter', 'nucleocytoplasmic transport', 'positive regulation of JNK cascade', 'positive regulation of JUN kinase activity', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of protein catabolic process', 'positive regulation of protein kinase activity', 'positive regulation of protein phosphorylation', 'positive regulation of protein ubiquitination', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta receptor signaling pathway', 'positive regulation of ubiquitin-dependent protein catabolic process', 'positive regulation of ubiquitin-protein transferase activity', 'post-anal tail morphogenesis', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein polyubiquitination', 'protein-containing complex assembly', 'sensory perception of sound']['bicellular tight junction assembly', 'cell adhesion', 'cell fate specification', 'cell migration', 'cellular response to DNA damage stimulus', 'insulin receptor signaling pathway', 'mitotic cytokinesis', 'mitotic spindle assembly checkpoint signaling', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell cycle G1/S phase transition', 'negative regulation of cell population proliferation', 'negative regulation of cyclin-dependent protein serine/threonine kinase activity', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of microtubule depolymerization', 'nervous system development', 'pattern specification process', 'positive regulation of apoptotic process', 'positive regulation of cell death', 'positive regulation of cell migration', 'positive regulation of cold-induced thermogenesis', 'positive regulation of protein catabolic process', 'positive regulation of protein localization to centrosome', 'positive regulation of pseudopodium assembly', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein-containing complex assembly', 'regulation of attachment of spindle microtubules to kinetochore', 'regulation of cell differentiation', 'regulation of microtubule-based process', 'Wnt signaling pathway']
Artemin
187
Artemin
188
10.0
71
0.14
Q5T4W7Q5T4W7['axon guidance', 'induction of positive chemotaxis', 'lymphocyte migration into lymphoid organs', 'neuroblast proliferation', 'peripheral nervous system development', "Peyer's patch morphogenesis", 'signal transduction']['axon guidance', 'induction of positive chemotaxis', 'lymphocyte migration into lymphoid organs', 'neuroblast proliferation', 'peripheral nervous system development', "Peyer's patch morphogenesis", 'signal transduction']
Mothers against decapentaplegic homolog 7
319
Mothers against decapentaplegic homolog 7
319
8.2
80
0.15
O35253O35253['adherens junction assembly', 'anatomical structure morphogenesis', 'artery morphogenesis', 'BMP signaling pathway', 'cell differentiation', 'cellular response to leukemia inhibitory factor', 'cellular response to transforming growth factor beta stimulus', 'intracellular signal transduction', 'negative regulation of BMP signaling pathway', 'negative regulation of chondrocyte proliferation', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of ossification', 'negative regulation of pathway-restricted SMAD protein phosphorylation', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of peptidyl-threonine phosphorylation', 'negative regulation of protein ubiquitination', 'negative regulation of T cell cytokine production', 'negative regulation of T-helper 17 cell differentiation', 'negative regulation of T-helper 17 type immune response', 'negative regulation of transcription by competitive promoter binding', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of ubiquitin-protein transferase activity', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of cell-cell adhesion', 'positive regulation of chondrocyte hypertrophy', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of protein ubiquitination', 'protein stabilization', 'protein-containing complex localization', 'regulation of activin receptor signaling pathway', 'regulation of cardiac muscle contraction', 'regulation of epithelial to mesenchymal transition', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulation of ventricular cardiac muscle cell membrane depolarization', 'response to laminar fluid shear stress', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'ureteric bud development', 'ventricular cardiac muscle tissue morphogenesis', 'ventricular septum morphogenesis']['adherens junction assembly', 'anatomical structure morphogenesis', 'artery morphogenesis', 'BMP signaling pathway', 'cell differentiation', 'cellular response to leukemia inhibitory factor', 'cellular response to transforming growth factor beta stimulus', 'intracellular signal transduction', 'negative regulation of BMP signaling pathway', 'negative regulation of chondrocyte proliferation', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of ossification', 'negative regulation of pathway-restricted SMAD protein phosphorylation', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of peptidyl-threonine phosphorylation', 'negative regulation of protein ubiquitination', 'negative regulation of T cell cytokine production', 'negative regulation of T-helper 17 cell differentiation', 'negative regulation of T-helper 17 type immune response', 'negative regulation of transcription by competitive promoter binding', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of ubiquitin-protein transferase activity', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of cell-cell adhesion', 'positive regulation of chondrocyte hypertrophy', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of protein ubiquitination', 'protein stabilization', 'protein-containing complex localization', 'regulation of activin receptor signaling pathway', 'regulation of cardiac muscle contraction', 'regulation of epithelial to mesenchymal transition', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulation of ventricular cardiac muscle cell membrane depolarization', 'response to laminar fluid shear stress', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'ureteric bud development', 'ventricular cardiac muscle tissue morphogenesis', 'ventricular septum morphogenesis']
Trypsin
49
Tissue factor pathway inhibitor
158
9.8
85
0.12
P00761P10646['digestion', 'proteolysis']['blood coagulation', 'cellular response to steroid hormone stimulus', 'negative regulation of blood coagulation']
Glandular kallikrein
49
Pancreatic trypsin inhibitor
49
8.8
94
0.12
P00752P00974['regulation of systemic arterial blood pressure', 'zymogen activation']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Hemoglobin subunit alpha
111
Hemoglobin subunit beta
112
8.9
81
0.14
P60523P60526[][]
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
165
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
157
10.0
67
0.15
Q01064Q01064['cellular response to granulocyte macrophage colony-stimulating factor stimulus', 'cellular response to macrophage colony-stimulating factor stimulus', 'locomotory behavior', 'monocyte differentiation', 'regulation of dopamine metabolic process', 'regulation of neurotransmitter levels', 'response to amphetamine', 'serotonin metabolic process', 'signal transduction', 'visual learning']['cellular response to granulocyte macrophage colony-stimulating factor stimulus', 'cellular response to macrophage colony-stimulating factor stimulus', 'locomotory behavior', 'monocyte differentiation', 'regulation of dopamine metabolic process', 'regulation of neurotransmitter levels', 'response to amphetamine', 'serotonin metabolic process', 'signal transduction', 'visual learning']
Hepatocyte growth factor activator
432
Kunitz-type protease inhibitor 1
259
8.9
99
0.11
Q04756O43278['blood coagulation', 'proteolysis', 'zymogen activation']['branching involved in labyrinthine layer morphogenesis', 'cellular response to BMP stimulus', 'epidermis development', 'epithelium development', 'extracellular matrix organization', 'negative regulation of neural precursor cell proliferation', 'neural tube closure', 'placenta blood vessel development', 'positive regulation of glial cell differentiation']
F-box only protein 11
853
F-box only protein 11
890
8.7
71
0.16
Q86XK2Q86XK2['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']
Poly(ADP-ribose) glycohydrolase
599
Poly(ADP-ribose) glycohydrolase
599
10.0
54
0.19
Q9QYM2Q9QYM2['ATP generation from poly-ADP-D-ribose', 'carbohydrate metabolic process', 'cellular response to DNA damage stimulus', 'detection of bacterium', 'nucleotide-sugar metabolic process', 'positive regulation of DNA repair', 'regulation of DNA repair', 'regulation of histone modification']['ATP generation from poly-ADP-D-ribose', 'carbohydrate metabolic process', 'cellular response to DNA damage stimulus', 'detection of bacterium', 'nucleotide-sugar metabolic process', 'positive regulation of DNA repair', 'regulation of DNA repair', 'regulation of histone modification']
Proproteinase E
196
Proproteinase E
227
8.1
96
0.13
P05805P05805['digestion', 'proteolysis']['digestion', 'proteolysis']
Tyrosine-protein kinase ABL1
330
Tyrosine-protein kinase ABL1
330
9.9
63
0.16
P00519P00519['actin cytoskeleton organization', 'actin filament polymerization', 'activated T cell proliferation', 'activation of protein kinase C activity', 'alpha-beta T cell differentiation', 'associative learning', 'autophagy', 'B cell proliferation involved in immune response', 'B cell receptor signaling pathway', 'B-1 B cell homeostasis', 'Bergmann glial cell differentiation', 'BMP signaling pathway', 'cell-cell adhesion', 'cellular response to DNA damage stimulus', 'cellular response to dopamine', 'cellular response to hydrogen peroxide', 'cellular response to lipopolysaccharide', 'cellular response to oxidative stress', 'cellular response to transforming growth factor beta stimulus', 'cellular senescence', 'cerebellum morphogenesis', 'circulatory system development', 'DN4 thymocyte differentiation', 'DNA conformation change', 'DNA damage induced protein phosphorylation', 'endocytosis', 'endothelial cell migration', 'epidermal growth factor receptor signaling pathway', 'ERK1 and ERK2 cascade', 'establishment of localization in cell', 'Fc-gamma receptor signaling pathway involved in phagocytosis', 'I-kappaB kinase/NF-kappaB signaling', 'integrin-mediated signaling pathway', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'microspike assembly', 'mismatch repair', 'mitochondrial depolarization', 'mitotic cell cycle', 'negative regulation of BMP signaling pathway', 'negative regulation of cell-cell adhesion', 'negative regulation of cellular senescence', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of long-term synaptic potentiation', 'negative regulation of mitotic cell cycle', 'negative regulation of phospholipase C activity', 'negative regulation of protein serine/threonine kinase activity', 'negative regulation of ubiquitin-protein transferase activity', 'neural tube closure', 'neuroepithelial cell differentiation', 'neuromuscular process controlling balance', 'neuron death', 'neuron differentiation', 'neuropilin signaling pathway', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'platelet-derived growth factor receptor-beta signaling pathway', 'podocyte apoptotic process', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of actin filament binding', 'positive regulation of apoptotic process', 'positive regulation of blood vessel branching', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of dendrite development', 'positive regulation of endothelial cell migration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of establishment of T cell polarity', 'positive regulation of extracellular matrix organization', 'positive regulation of fibroblast proliferation', 'positive regulation of focal adhesion assembly', 'positive regulation of hydrogen peroxide-mediated programmed cell death', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-2 production', 'positive regulation of microtubule binding', 'positive regulation of mitotic cell cycle', 'positive regulation of neuron apoptotic process', 'positive regulation of osteoblast proliferation', 'positive regulation of oxidoreductase activity', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein phosphorylation', 'positive regulation of release of sequestered calcium ion into cytosol', 'positive regulation of stress fiber assembly', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of T cell migration', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vasoconstriction', 'positive regulation of Wnt signaling pathway, planar cell polarity pathway', 'post-embryonic development', 'protein autophosphorylation', 'protein localization to cytoplasmic microtubule plus-end', 'protein modification process', 'protein phosphorylation', 'regulation of actin cytoskeleton organization', 'regulation of actin cytoskeleton reorganization', 'regulation of apoptotic process', 'regulation of autophagy', 'regulation of axon extension', 'regulation of Cdc42 protein signal transduction', 'regulation of cell adhesion', 'regulation of cell cycle', 'regulation of cell motility', 'regulation of endocytosis', 'regulation of hematopoietic stem cell differentiation', 'regulation of microtubule polymerization', 'regulation of modification of synaptic structure', 'regulation of response to DNA damage stimulus', 'regulation of T cell differentiation', 'regulation of transcription, DNA-templated', 'response to endoplasmic reticulum stress', 'response to epinephrine', 'response to oxidative stress', 'response to xenobiotic stimulus', 'signal transduction in response to DNA damage', 'spleen development', 'substrate adhesion-dependent cell spreading', 'T cell receptor signaling pathway', 'thymus development', 'transitional one stage B cell differentiation']['actin cytoskeleton organization', 'actin filament polymerization', 'activated T cell proliferation', 'activation of protein kinase C activity', 'alpha-beta T cell differentiation', 'associative learning', 'autophagy', 'B cell proliferation involved in immune response', 'B cell receptor signaling pathway', 'B-1 B cell homeostasis', 'Bergmann glial cell differentiation', 'BMP signaling pathway', 'cell-cell adhesion', 'cellular response to DNA damage stimulus', 'cellular response to dopamine', 'cellular response to hydrogen peroxide', 'cellular response to lipopolysaccharide', 'cellular response to oxidative stress', 'cellular response to transforming growth factor beta stimulus', 'cellular senescence', 'cerebellum morphogenesis', 'circulatory system development', 'DN4 thymocyte differentiation', 'DNA conformation change', 'DNA damage induced protein phosphorylation', 'endocytosis', 'endothelial cell migration', 'epidermal growth factor receptor signaling pathway', 'ERK1 and ERK2 cascade', 'establishment of localization in cell', 'Fc-gamma receptor signaling pathway involved in phagocytosis', 'I-kappaB kinase/NF-kappaB signaling', 'integrin-mediated signaling pathway', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'microspike assembly', 'mismatch repair', 'mitochondrial depolarization', 'mitotic cell cycle', 'negative regulation of BMP signaling pathway', 'negative regulation of cell-cell adhesion', 'negative regulation of cellular senescence', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of long-term synaptic potentiation', 'negative regulation of mitotic cell cycle', 'negative regulation of phospholipase C activity', 'negative regulation of protein serine/threonine kinase activity', 'negative regulation of ubiquitin-protein transferase activity', 'neural tube closure', 'neuroepithelial cell differentiation', 'neuromuscular process controlling balance', 'neuron death', 'neuron differentiation', 'neuropilin signaling pathway', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'platelet-derived growth factor receptor-beta signaling pathway', 'podocyte apoptotic process', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of actin filament binding', 'positive regulation of apoptotic process', 'positive regulation of blood vessel branching', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of dendrite development', 'positive regulation of endothelial cell migration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of establishment of T cell polarity', 'positive regulation of extracellular matrix organization', 'positive regulation of fibroblast proliferation', 'positive regulation of focal adhesion assembly', 'positive regulation of hydrogen peroxide-mediated programmed cell death', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-2 production', 'positive regulation of microtubule binding', 'positive regulation of mitotic cell cycle', 'positive regulation of neuron apoptotic process', 'positive regulation of osteoblast proliferation', 'positive regulation of oxidoreductase activity', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein phosphorylation', 'positive regulation of release of sequestered calcium ion into cytosol', 'positive regulation of stress fiber assembly', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of T cell migration', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vasoconstriction', 'positive regulation of Wnt signaling pathway, planar cell polarity pathway', 'post-embryonic development', 'protein autophosphorylation', 'protein localization to cytoplasmic microtubule plus-end', 'protein modification process', 'protein phosphorylation', 'regulation of actin cytoskeleton organization', 'regulation of actin cytoskeleton reorganization', 'regulation of apoptotic process', 'regulation of autophagy', 'regulation of axon extension', 'regulation of Cdc42 protein signal transduction', 'regulation of cell adhesion', 'regulation of cell cycle', 'regulation of cell motility', 'regulation of endocytosis', 'regulation of hematopoietic stem cell differentiation', 'regulation of microtubule polymerization', 'regulation of modification of synaptic structure', 'regulation of response to DNA damage stimulus', 'regulation of T cell differentiation', 'regulation of transcription, DNA-templated', 'response to endoplasmic reticulum stress', 'response to epinephrine', 'response to oxidative stress', 'response to xenobiotic stimulus', 'signal transduction in response to DNA damage', 'spleen development', 'substrate adhesion-dependent cell spreading', 'T cell receptor signaling pathway', 'thymus development', 'transitional one stage B cell differentiation']
Mucin-2
1088
Mucin-2
1092
8.1
84
0.15
Q02817Q02817['maintenance of gastrointestinal epithelium']['maintenance of gastrointestinal epithelium']
Poly [ADP-ribose] polymerase
973
Poly [ADP-ribose] polymerase
973
8.2
59
0.21
Q59FX0Q59FX0['positive regulation of telomere maintenance via telomerase', 'spindle assembly', 'Wnt signaling pathway']['positive regulation of telomere maintenance via telomerase', 'spindle assembly', 'Wnt signaling pathway']
Fibrinogen alpha chain
64
Fibrinogen gamma chain
45
8.1
85
0.15
P02671P02679['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'fibrinolysis', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of platelet aggregation', 'plasminogen activation', 'platelet aggregation', 'platelet maturation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein secretion', 'protein-containing complex assembly', 'response to calcium ion']
DNA-binding protein SMUBP-2
258
DNA-binding protein SMUBP-2
191
8.7
47
0.24
P38935P38935['DNA duplex unwinding', 'RNA secondary structure unwinding']['DNA duplex unwinding', 'RNA secondary structure unwinding']
Bone morphogenetic protein 3
399
Bone morphogenetic protein 3
436
8.9
88
0.13
P12645P12645['cartilage development', 'cell-cell signaling', 'osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'skeletal system development', 'SMAD protein signal transduction']['cartilage development', 'cell-cell signaling', 'osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'skeletal system development', 'SMAD protein signal transduction']
Trypsin
33
Antileukoproteinase
122
8.1
88
0.14
P00761P03973['digestion', 'proteolysis']['antibacterial humoral response', 'immune response', 'innate immune response', 'modulation of process of another organism', 'negative regulation of protein binding', 'negative regulation of viral genome replication', 'response to lipopolysaccharide']
Glutamate receptor 2
78
Glutamate receptor 4
84
8.2
73
0.17
P19491P19493['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']['chemical synaptic transmission', 'modulation of chemical synaptic transmission', 'negative regulation of smooth muscle cell apoptotic process', 'positive regulation of synaptic transmission, glutamatergic', 'regulation of synapse structure or activity', 'response to fungicide']
Cytochrome c
18
Cytochrome c
18
8.2
45
0.27
P00004P00004['apoptotic process', 'cytochrome c-heme linkage', 'mitochondrial electron transport, cytochrome c to oxygen', 'mitochondrial electron transport, ubiquinol to cytochrome c', 'positive regulation of apoptotic process', 'positive regulation of cysteine-type endopeptidase activity', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process']['apoptotic process', 'cytochrome c-heme linkage', 'mitochondrial electron transport, cytochrome c to oxygen', 'mitochondrial electron transport, ubiquinol to cytochrome c', 'positive regulation of apoptotic process', 'positive regulation of cysteine-type endopeptidase activity', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process']
Prothrombin
407
Pancreatic trypsin inhibitor
49
8.7
98
0.12
P00734P00974['acute-phase response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'blood coagulation', 'blood coagulation, common pathway', 'cell surface receptor signaling pathway', 'cytolysis by host of symbiont cells', 'fibrinolysis', 'negative regulation of astrocyte differentiation', 'negative regulation of blood coagulation', 'negative regulation of cytokine production involved in inflammatory response', 'negative regulation of fibrinolysis', 'negative regulation of platelet activation', 'negative regulation of proteolysis', 'neutrophil-mediated killing of gram-negative bacterium', 'platelet activation', 'positive regulation of blood coagulation', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of lipid kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to nucleus', 'positive regulation of protein phosphorylation', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of release of sequestered calcium ion into cytosol', 'proteolysis', 'regulation of blood coagulation', 'regulation of cell shape', 'regulation of cytosolic calcium ion concentration', 'response to wounding', 'zymogen activation']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
C-C chemokine receptor type 5
269
C-C motif chemokine 5
73
9.8
62
0.16
P51681P13501['calcium ion transport', 'calcium-mediated signaling', 'cell chemotaxis', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular defense response', 'cellular response to lipopolysaccharide', 'chemotaxis', 'dendritic cell chemotaxis', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'MAPK cascade', 'positive regulation of cytosolic calcium ion concentration', 'release of sequestered calcium ion into cytosol by sarcoplasmic reticulum', 'response to cholesterol', 'signaling']['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'chemokine-mediated signaling pathway', 'chemotaxis', 'dendritic cell chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of innate immune response', 'positive regulation of macrophage chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of translational initiation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of viral genome replication', 'protein kinase B signaling', 'regulation of chronic inflammatory response', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to toxic substance', 'response to virus']
Neurogenic locus notch homolog protein 1
1545
Neurogenic locus notch homolog protein 1
1545
8.8
57
0.2
P46531P46531['animal organ regeneration', 'aortic valve morphogenesis', 'apoptotic process involved in embryonic digit morphogenesis', 'arterial endothelial cell differentiation', 'astrocyte differentiation', 'atrioventricular node development', 'atrioventricular valve morphogenesis', 'auditory receptor cell fate commitment', 'axon guidance', 'branching morphogenesis of an epithelial tube', 'calcium-ion regulated exocytosis', 'cardiac atrium morphogenesis', 'cardiac chamber formation', 'cardiac epithelial to mesenchymal transition', 'cardiac left ventricle morphogenesis', 'cardiac muscle cell myoblast differentiation', 'cardiac muscle cell proliferation', 'cardiac muscle tissue morphogenesis', 'cardiac right atrium morphogenesis', 'cardiac right ventricle formation', 'cardiac septum morphogenesis', 'cardiac vascular smooth muscle cell development', 'cardiac ventricle morphogenesis', 'cell differentiation in spinal cord', 'cell migration involved in endocardial cushion formation', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to tumor cell', 'cellular response to vascular endothelial growth factor stimulus', 'cilium assembly', 'collecting duct development', 'compartment pattern specification', 'coronary artery morphogenesis', 'coronary sinus valve morphogenesis', 'coronary vein morphogenesis', 'determination of left/right symmetry', 'distal tubule development', 'embryonic hindlimb morphogenesis', 'endocardial cell differentiation', 'endocardial cushion morphogenesis', 'endocardium development', 'endocardium morphogenesis', 'endoderm development', 'epidermal cell fate specification', 'epithelial cell fate commitment', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'epithelial to mesenchymal transition involved in endocardial cushion formation', 'forebrain development', 'foregut morphogenesis', 'glomerular mesangial cell development', 'growth involved in heart morphogenesis', 'hair follicle morphogenesis', 'heart development', 'heart looping', 'heart trabecula morphogenesis', 'homeostasis of number of cells within a tissue', 'humoral immune response', 'immune response', 'in utero embryonic development', 'inflammatory response to antigenic stimulus', 'inhibition of neuroepithelial cell differentiation', 'interleukin-17-mediated signaling pathway', 'keratinocyte differentiation', 'left/right axis specification', 'liver development', 'lung development', 'mesenchymal cell development', 'mitral valve formation', 'negative regulation of anoikis', 'negative regulation of biomineral tissue development', 'negative regulation of BMP signaling pathway', 'negative regulation of calcium ion-dependent exocytosis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of catalytic activity', 'negative regulation of cell adhesion molecule production', 'negative regulation of cell migration involved in sprouting angiogenesis', 'negative regulation of cell population proliferation', 'negative regulation of cell proliferation involved in heart valve morphogenesis', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cell-substrate adhesion', 'negative regulation of cold-induced thermogenesis', 'negative regulation of endothelial cell chemotaxis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix constituent secretion', 'negative regulation of gene expression', 'negative regulation of glial cell proliferation', 'negative regulation of inner ear auditory receptor cell differentiation', 'negative regulation of myoblast differentiation', 'negative regulation of myotube differentiation', 'negative regulation of neurogenesis', 'negative regulation of oligodendrocyte differentiation', 'negative regulation of ossification', 'negative regulation of osteoblast differentiation', 'negative regulation of photoreceptor cell differentiation', 'negative regulation of pro-B cell differentiation', 'negative regulation of stem cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube development', 'neuroendocrine cell differentiation', 'neuronal stem cell population maintenance', 'Notch signaling involved in heart development', 'Notch signaling pathway', 'Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation', 'oligodendrocyte differentiation', 'outflow tract morphogenesis', 'pericardium morphogenesis', 'positive regulation of aorta morphogenesis', 'positive regulation of apoptotic process involved in morphogenesis', 'positive regulation of astrocyte differentiation', 'positive regulation of BMP signaling pathway', 'positive regulation of cardiac epithelial to mesenchymal transition', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell differentiation', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of keratinocyte differentiation', 'positive regulation of neuroblast proliferation', 'positive regulation of Notch signaling pathway', 'positive regulation of Ras protein signal transduction', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription of Notch receptor target', 'positive regulation of transcription, DNA-templated', 'positive regulation of viral genome replication', 'prostate gland epithelium morphogenesis', 'protein catabolic process', 'protein import into nucleus', 'pulmonary valve morphogenesis', 'regulation of epithelial cell proliferation involved in prostate gland development', 'regulation of extracellular matrix assembly', 'regulation of somitogenesis', 'regulation of stem cell proliferation', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to corticosteroid', 'response to lipopolysaccharide', 'response to muramyl dipeptide', 'retinal cone cell differentiation', 'secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development', 'skeletal muscle cell differentiation', 'somatic stem cell division', 'spermatogenesis', 'sprouting angiogenesis', 'T-helper 17 type immune response', 'tissue regeneration', 'transcription by RNA polymerase II', 'tube formation', 'vasculogenesis involved in coronary vascular morphogenesis', 'venous endothelial cell differentiation', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis']['animal organ regeneration', 'aortic valve morphogenesis', 'apoptotic process involved in embryonic digit morphogenesis', 'arterial endothelial cell differentiation', 'astrocyte differentiation', 'atrioventricular node development', 'atrioventricular valve morphogenesis', 'auditory receptor cell fate commitment', 'axon guidance', 'branching morphogenesis of an epithelial tube', 'calcium-ion regulated exocytosis', 'cardiac atrium morphogenesis', 'cardiac chamber formation', 'cardiac epithelial to mesenchymal transition', 'cardiac left ventricle morphogenesis', 'cardiac muscle cell myoblast differentiation', 'cardiac muscle cell proliferation', 'cardiac muscle tissue morphogenesis', 'cardiac right atrium morphogenesis', 'cardiac right ventricle formation', 'cardiac septum morphogenesis', 'cardiac vascular smooth muscle cell development', 'cardiac ventricle morphogenesis', 'cell differentiation in spinal cord', 'cell migration involved in endocardial cushion formation', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to tumor cell', 'cellular response to vascular endothelial growth factor stimulus', 'cilium assembly', 'collecting duct development', 'compartment pattern specification', 'coronary artery morphogenesis', 'coronary sinus valve morphogenesis', 'coronary vein morphogenesis', 'determination of left/right symmetry', 'distal tubule development', 'embryonic hindlimb morphogenesis', 'endocardial cell differentiation', 'endocardial cushion morphogenesis', 'endocardium development', 'endocardium morphogenesis', 'endoderm development', 'epidermal cell fate specification', 'epithelial cell fate commitment', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'epithelial to mesenchymal transition involved in endocardial cushion formation', 'forebrain development', 'foregut morphogenesis', 'glomerular mesangial cell development', 'growth involved in heart morphogenesis', 'hair follicle morphogenesis', 'heart development', 'heart looping', 'heart trabecula morphogenesis', 'homeostasis of number of cells within a tissue', 'humoral immune response', 'immune response', 'in utero embryonic development', 'inflammatory response to antigenic stimulus', 'inhibition of neuroepithelial cell differentiation', 'interleukin-17-mediated signaling pathway', 'keratinocyte differentiation', 'left/right axis specification', 'liver development', 'lung development', 'mesenchymal cell development', 'mitral valve formation', 'negative regulation of anoikis', 'negative regulation of biomineral tissue development', 'negative regulation of BMP signaling pathway', 'negative regulation of calcium ion-dependent exocytosis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of catalytic activity', 'negative regulation of cell adhesion molecule production', 'negative regulation of cell migration involved in sprouting angiogenesis', 'negative regulation of cell population proliferation', 'negative regulation of cell proliferation involved in heart valve morphogenesis', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cell-substrate adhesion', 'negative regulation of cold-induced thermogenesis', 'negative regulation of endothelial cell chemotaxis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix constituent secretion', 'negative regulation of gene expression', 'negative regulation of glial cell proliferation', 'negative regulation of inner ear auditory receptor cell differentiation', 'negative regulation of myoblast differentiation', 'negative regulation of myotube differentiation', 'negative regulation of neurogenesis', 'negative regulation of oligodendrocyte differentiation', 'negative regulation of ossification', 'negative regulation of osteoblast differentiation', 'negative regulation of photoreceptor cell differentiation', 'negative regulation of pro-B cell differentiation', 'negative regulation of stem cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube development', 'neuroendocrine cell differentiation', 'neuronal stem cell population maintenance', 'Notch signaling involved in heart development', 'Notch signaling pathway', 'Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation', 'oligodendrocyte differentiation', 'outflow tract morphogenesis', 'pericardium morphogenesis', 'positive regulation of aorta morphogenesis', 'positive regulation of apoptotic process involved in morphogenesis', 'positive regulation of astrocyte differentiation', 'positive regulation of BMP signaling pathway', 'positive regulation of cardiac epithelial to mesenchymal transition', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell differentiation', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of keratinocyte differentiation', 'positive regulation of neuroblast proliferation', 'positive regulation of Notch signaling pathway', 'positive regulation of Ras protein signal transduction', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription of Notch receptor target', 'positive regulation of transcription, DNA-templated', 'positive regulation of viral genome replication', 'prostate gland epithelium morphogenesis', 'protein catabolic process', 'protein import into nucleus', 'pulmonary valve morphogenesis', 'regulation of epithelial cell proliferation involved in prostate gland development', 'regulation of extracellular matrix assembly', 'regulation of somitogenesis', 'regulation of stem cell proliferation', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to corticosteroid', 'response to lipopolysaccharide', 'response to muramyl dipeptide', 'retinal cone cell differentiation', 'secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development', 'skeletal muscle cell differentiation', 'somatic stem cell division', 'spermatogenesis', 'sprouting angiogenesis', 'T-helper 17 type immune response', 'tissue regeneration', 'transcription by RNA polymerase II', 'tube formation', 'vasculogenesis involved in coronary vascular morphogenesis', 'venous endothelial cell differentiation', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis']
Inositol-trisphosphate 3-kinase A
340
Inositol-trisphosphate 3-kinase A
340
8.9
60
0.19
P17105P17105['actin cytoskeleton organization', 'cellular response to calcium ion', 'dendritic spine maintenance', 'inositol metabolic process', 'inositol phosphate biosynthetic process', 'phosphatidylinositol phosphate biosynthetic process', 'phosphorylation', 'positive regulation of dendritic spine morphogenesis', 'regulation of synaptic plasticity', 'response to calcium ion']['actin cytoskeleton organization', 'cellular response to calcium ion', 'dendritic spine maintenance', 'inositol metabolic process', 'inositol phosphate biosynthetic process', 'phosphatidylinositol phosphate biosynthetic process', 'phosphorylation', 'positive regulation of dendritic spine morphogenesis', 'regulation of synaptic plasticity', 'response to calcium ion']
Fibrinogen alpha chain
184
Fibrinogen beta chain
227
8.1
63
0.2
P02671P02675['adaptive immune response', 'blood coagulation, common pathway', 'blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of blood coagulation, common pathway', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']['adaptive immune response', 'blood coagulation, fibrin clot formation', 'cell adhesion', 'cell-matrix adhesion', 'cellular response to interleukin-1', 'cellular response to leptin stimulus', 'fibrinolysis', 'induction of bacterial agglutination', 'innate immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'plasminogen activation', 'platelet aggregation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of exocytosis', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of peptide hormone secretion', 'positive regulation of protein secretion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of vasoconstriction', 'protein polymerization', 'protein-containing complex assembly', 'response to calcium ion']
Glutamate receptor 2
78
Glutamate receptor 2
78
8.1
73
0.17
P42262P42262['chemical synaptic transmission', 'ionotropic glutamate receptor signaling pathway', 'signal transduction', 'synaptic transmission, glutamatergic']['chemical synaptic transmission', 'ionotropic glutamate receptor signaling pathway', 'signal transduction', 'synaptic transmission, glutamatergic']
ADP-ribosylation factor 1
159
ADP-ribosylation factor 1
159
10.0
69
0.15
P84077P84077['cellular copper ion homeostasis', 'cellular response to virus', 'dendritic spine organization', 'intracellular protein transport', 'long-term synaptic depression', 'mitotic cleavage furrow ingression', 'regulation of Arp2/3 complex-mediated actin nucleation', 'regulation of receptor internalization', 'vesicle-mediated transport']['cellular copper ion homeostasis', 'cellular response to virus', 'dendritic spine organization', 'intracellular protein transport', 'long-term synaptic depression', 'mitotic cleavage furrow ingression', 'regulation of Arp2/3 complex-mediated actin nucleation', 'regulation of receptor internalization', 'vesicle-mediated transport']
Cellular tumor antigen p53
238
Cellular tumor antigen p53
182
10.0
77
0.13
P04637P04637['autophagy', 'B cell lineage commitment', 'bone marrow development', 'cardiac muscle cell apoptotic process', 'cardiac septum morphogenesis', 'cellular response to actinomycin D', 'cellular response to DNA damage stimulus', 'cellular response to gamma radiation', 'cellular response to glucose starvation', 'cellular response to hypoxia', 'cellular response to ionizing radiation', 'cellular response to UV', 'cellular response to UV-C', 'cellular response to xenobiotic stimulus', 'cellular senescence', 'cerebellum development', 'chromatin assembly', 'circadian behavior', 'determination of adult lifespan', 'DNA damage response, signal transduction by p53 class mediator', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator', 'double-strand break repair', 'embryonic organ development', 'entrainment of circadian clock by photoperiod', 'ER overload response', 'fibroblast proliferation', 'gastrulation', 'glial cell proliferation', 'glucose catabolic process to lactate via pyruvate', 'hematopoietic progenitor cell differentiation', 'hematopoietic stem cell differentiation', 'in utero embryonic development', 'interferon-gamma-mediated signaling pathway', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'intrinsic apoptotic signaling pathway in response to hypoxia', 'mitochondrial DNA repair', 'mitophagy', 'mitotic G1 DNA damage checkpoint signaling', 'mRNA transcription', 'multicellular organism growth', 'necroptotic process', 'negative regulation of apoptotic process', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of DNA replication', 'negative regulation of fibroblast proliferation', 'negative regulation of G1 to G0 transition', 'negative regulation of glial cell proliferation', 'negative regulation of glucose catabolic process to lactate via pyruvate', 'negative regulation of helicase activity', 'negative regulation of miRNA maturation', 'negative regulation of mitophagy', 'negative regulation of neuroblast proliferation', 'negative regulation of pentose-phosphate shunt', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of stem cell proliferation', 'negative regulation of telomerase activity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'neuroblast proliferation', 'neuron apoptotic process', 'nucleotide-excision repair', 'oligodendrocyte apoptotic process', 'oxidative stress-induced premature senescence', 'positive regulation of apoptotic process', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of cellular senescence', 'positive regulation of execution phase of apoptosis', 'positive regulation of gene expression', 'positive regulation of histone deacetylation', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of mitochondrial membrane permeability', 'positive regulation of neuron apoptotic process', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of programmed necrotic cell death', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of release of cytochrome c from mitochondria', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of thymocyte apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription from RNA polymerase II promoter in response to stress', 'positive regulation of transcription, DNA-templated', 'protein import into nucleus', 'protein localization', 'protein stabilization', 'protein tetramerization', 'protein-containing complex assembly', 'Ras protein signal transduction', 'reactive oxygen species metabolic process', 'regulation of apoptotic process', 'regulation of cell cycle', 'regulation of cell cycle G2/M phase transition', 'regulation of DNA damage response, signal transduction by p53 class mediator', 'regulation of fibroblast apoptotic process', 'regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'regulation of mitochondrial membrane permeability involved in apoptotic process', 'regulation of tissue remodeling', 'regulation of transcription by RNA polymerase II', 'regulation of transcription from RNA polymerase II promoter in response to DNA damage', 'regulation of transcription, DNA-templated', 'release of cytochrome c from mitochondria', 'replicative senescence', 'response to antibiotic', 'response to gamma radiation', 'response to ischemia', 'response to salt stress', 'response to X-ray', 'rRNA transcription', 'signal transduction by p53 class mediator', 'somitogenesis', 'stem cell proliferation', 'T cell differentiation in thymus', 'T cell lineage commitment', 'T cell proliferation involved in immune response', 'thymocyte apoptotic process', 'transforming growth factor beta receptor signaling pathway', 'tumor necrosis factor-mediated signaling pathway', 'viral process']['autophagy', 'B cell lineage commitment', 'bone marrow development', 'cardiac muscle cell apoptotic process', 'cardiac septum morphogenesis', 'cellular response to actinomycin D', 'cellular response to DNA damage stimulus', 'cellular response to gamma radiation', 'cellular response to glucose starvation', 'cellular response to hypoxia', 'cellular response to ionizing radiation', 'cellular response to UV', 'cellular response to UV-C', 'cellular response to xenobiotic stimulus', 'cellular senescence', 'cerebellum development', 'chromatin assembly', 'circadian behavior', 'determination of adult lifespan', 'DNA damage response, signal transduction by p53 class mediator', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator', 'double-strand break repair', 'embryonic organ development', 'entrainment of circadian clock by photoperiod', 'ER overload response', 'fibroblast proliferation', 'gastrulation', 'glial cell proliferation', 'glucose catabolic process to lactate via pyruvate', 'hematopoietic progenitor cell differentiation', 'hematopoietic stem cell differentiation', 'in utero embryonic development', 'interferon-gamma-mediated signaling pathway', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'intrinsic apoptotic signaling pathway in response to hypoxia', 'mitochondrial DNA repair', 'mitophagy', 'mitotic G1 DNA damage checkpoint signaling', 'mRNA transcription', 'multicellular organism growth', 'necroptotic process', 'negative regulation of apoptotic process', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of DNA replication', 'negative regulation of fibroblast proliferation', 'negative regulation of G1 to G0 transition', 'negative regulation of glial cell proliferation', 'negative regulation of glucose catabolic process to lactate via pyruvate', 'negative regulation of helicase activity', 'negative regulation of miRNA maturation', 'negative regulation of mitophagy', 'negative regulation of neuroblast proliferation', 'negative regulation of pentose-phosphate shunt', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of stem cell proliferation', 'negative regulation of telomerase activity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'neuroblast proliferation', 'neuron apoptotic process', 'nucleotide-excision repair', 'oligodendrocyte apoptotic process', 'oxidative stress-induced premature senescence', 'positive regulation of apoptotic process', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of cellular senescence', 'positive regulation of execution phase of apoptosis', 'positive regulation of gene expression', 'positive regulation of histone deacetylation', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of mitochondrial membrane permeability', 'positive regulation of neuron apoptotic process', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of programmed necrotic cell death', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of release of cytochrome c from mitochondria', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of thymocyte apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription from RNA polymerase II promoter in response to stress', 'positive regulation of transcription, DNA-templated', 'protein import into nucleus', 'protein localization', 'protein stabilization', 'protein tetramerization', 'protein-containing complex assembly', 'Ras protein signal transduction', 'reactive oxygen species metabolic process', 'regulation of apoptotic process', 'regulation of cell cycle', 'regulation of cell cycle G2/M phase transition', 'regulation of DNA damage response, signal transduction by p53 class mediator', 'regulation of fibroblast apoptotic process', 'regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'regulation of mitochondrial membrane permeability involved in apoptotic process', 'regulation of tissue remodeling', 'regulation of transcription by RNA polymerase II', 'regulation of transcription from RNA polymerase II promoter in response to DNA damage', 'regulation of transcription, DNA-templated', 'release of cytochrome c from mitochondria', 'replicative senescence', 'response to antibiotic', 'response to gamma radiation', 'response to ischemia', 'response to salt stress', 'response to X-ray', 'rRNA transcription', 'signal transduction by p53 class mediator', 'somitogenesis', 'stem cell proliferation', 'T cell differentiation in thymus', 'T cell lineage commitment', 'T cell proliferation involved in immune response', 'thymocyte apoptotic process', 'transforming growth factor beta receptor signaling pathway', 'tumor necrosis factor-mediated signaling pathway', 'viral process']
Transforming growth factor beta-3 proprotein
377
Transforming growth factor beta-3 proprotein
344
8.9
92
0.12
P10600P10600['aging', 'BMP signaling pathway', 'cell-cell junction organization', 'detection of hypoxia', 'digestive tract development', 'embryonic neurocranium morphogenesis', 'face morphogenesis', 'female pregnancy', 'frontal suture morphogenesis', 'in utero embryonic development', 'inner ear development', 'lung alveolus development', 'mammary gland development', 'negative regulation of cell population proliferation', 'negative regulation of macrophage cytokine production', 'negative regulation of neuron apoptotic process', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of vascular associated smooth muscle cell proliferation', 'odontogenesis', 'ossification involved in bone remodeling', 'positive regulation of apoptotic process', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of filopodium assembly', 'positive regulation of MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stress fiber assembly', 'positive regulation of tight junction disassembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of cell population proliferation', 'response to estrogen', 'response to hypoxia', 'response to laminar fluid shear stress', 'response to progesterone', 'salivary gland morphogenesis', 'secondary palate development', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'wound healing']['aging', 'BMP signaling pathway', 'cell-cell junction organization', 'detection of hypoxia', 'digestive tract development', 'embryonic neurocranium morphogenesis', 'face morphogenesis', 'female pregnancy', 'frontal suture morphogenesis', 'in utero embryonic development', 'inner ear development', 'lung alveolus development', 'mammary gland development', 'negative regulation of cell population proliferation', 'negative regulation of macrophage cytokine production', 'negative regulation of neuron apoptotic process', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of vascular associated smooth muscle cell proliferation', 'odontogenesis', 'ossification involved in bone remodeling', 'positive regulation of apoptotic process', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of filopodium assembly', 'positive regulation of MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stress fiber assembly', 'positive regulation of tight junction disassembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of cell population proliferation', 'response to estrogen', 'response to hypoxia', 'response to laminar fluid shear stress', 'response to progesterone', 'salivary gland morphogenesis', 'secondary palate development', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'wound healing']
Receptor-type tyrosine-protein phosphatase N2
882
Receptor-type tyrosine-protein phosphatase N2
882
8.1
53
0.23
Q92932Q92932['insulin secretion involved in cellular response to glucose stimulus', 'lipid metabolic process', 'neurotransmitter secretion', 'protein dephosphorylation', 'regulation of secretion']['insulin secretion involved in cellular response to glucose stimulus', 'lipid metabolic process', 'neurotransmitter secretion', 'protein dephosphorylation', 'regulation of secretion']
Vascular endothelial growth factor A
77
Vascular endothelial growth factor A
94
8.9
67
0.17
Q96NW5Q96NW5['activation of protein kinase activity', 'angiogenesis', 'artery morphogenesis', 'basophil chemotaxis', 'branching involved in blood vessel morphogenesis', 'camera-type eye morphogenesis', 'cardiac muscle cell development', 'cardiac vascular smooth muscle cell development', 'cell maturation', 'cell migration involved in sprouting angiogenesis', 'cellular response to hypoxia', 'cellular response to vascular endothelial growth factor stimulus', 'cellular stress response to acid chemical', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'coronary vein morphogenesis', 'dopaminergic neuron differentiation', 'endothelial cell chemotaxis', 'epithelial cell differentiation', 'eye photoreceptor cell development', 'heart morphogenesis', 'in utero embryonic development', 'induction of positive chemotaxis', 'kidney development', 'lactation', 'lung development', 'lymph vessel morphogenesis', 'macrophage differentiation', 'mammary gland alveolus development', 'mesoderm development', 'monocyte differentiation', 'motor neuron migration', 'negative regulation of adherens junction organization', 'negative regulation of apoptotic process', 'negative regulation of blood-brain barrier permeability', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of establishment of endothelial barrier', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'outflow tract morphogenesis', 'ovarian follicle development', 'positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell migration by vascular endothelial growth factor signaling pathway', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway', 'positive regulation of cold-induced thermogenesis', 'positive regulation of CREB transcription factor activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of histone deacetylase activity', 'positive regulation of leukocyte migration', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of neuroblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of positive chemotaxis', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C signaling', 'positive regulation of protein kinase D signaling', 'positive regulation of protein localization to early endosome', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor internalization', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of trophoblast cell migration', 'positive regulation of vascular permeability', 'post-embryonic camera-type eye development', 'primitive erythrocyte differentiation', 'regulation of cell shape', 'regulation of nitric oxide mediated signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of transcription by RNA polymerase II', 'response to hypoxia', 'sprouting angiogenesis', 'surfactant homeostasis', 'tube formation', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway']['activation of protein kinase activity', 'angiogenesis', 'artery morphogenesis', 'basophil chemotaxis', 'branching involved in blood vessel morphogenesis', 'camera-type eye morphogenesis', 'cardiac muscle cell development', 'cardiac vascular smooth muscle cell development', 'cell maturation', 'cell migration involved in sprouting angiogenesis', 'cellular response to hypoxia', 'cellular response to vascular endothelial growth factor stimulus', 'cellular stress response to acid chemical', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'coronary vein morphogenesis', 'dopaminergic neuron differentiation', 'endothelial cell chemotaxis', 'epithelial cell differentiation', 'eye photoreceptor cell development', 'heart morphogenesis', 'in utero embryonic development', 'induction of positive chemotaxis', 'kidney development', 'lactation', 'lung development', 'lymph vessel morphogenesis', 'macrophage differentiation', 'mammary gland alveolus development', 'mesoderm development', 'monocyte differentiation', 'motor neuron migration', 'negative regulation of adherens junction organization', 'negative regulation of apoptotic process', 'negative regulation of blood-brain barrier permeability', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of establishment of endothelial barrier', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'outflow tract morphogenesis', 'ovarian follicle development', 'positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell migration by vascular endothelial growth factor signaling pathway', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway', 'positive regulation of cold-induced thermogenesis', 'positive regulation of CREB transcription factor activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of histone deacetylase activity', 'positive regulation of leukocyte migration', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of neuroblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of positive chemotaxis', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C signaling', 'positive regulation of protein kinase D signaling', 'positive regulation of protein localization to early endosome', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor internalization', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of trophoblast cell migration', 'positive regulation of vascular permeability', 'post-embryonic camera-type eye development', 'primitive erythrocyte differentiation', 'regulation of cell shape', 'regulation of nitric oxide mediated signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of transcription by RNA polymerase II', 'response to hypoxia', 'sprouting angiogenesis', 'surfactant homeostasis', 'tube formation', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway']
Glutamate receptor ionotropic, kainate 2
96
Glutamate receptor ionotropic, kainate 2
347
10.0
71
0.14
P42260P42260['behavioral fear response', 'cellular calcium ion homeostasis', 'chemical synaptic transmission', 'detection of cold stimulus involved in thermoception', 'excitatory postsynaptic potential', 'inhibitory postsynaptic potential', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of synaptic transmission, glutamatergic', 'neuron apoptotic process', 'neuronal action potential', 'positive regulation of neuron apoptotic process', 'positive regulation of synaptic transmission', 'presynaptic modulation of chemical synaptic transmission', 'receptor clustering', 'regulation of JNK cascade', 'regulation of long-term neuronal synaptic plasticity', 'regulation of membrane potential', 'regulation of short-term neuronal synaptic plasticity', 'synaptic transmission, glutamatergic']['behavioral fear response', 'cellular calcium ion homeostasis', 'chemical synaptic transmission', 'detection of cold stimulus involved in thermoception', 'excitatory postsynaptic potential', 'inhibitory postsynaptic potential', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of synaptic transmission, glutamatergic', 'neuron apoptotic process', 'neuronal action potential', 'positive regulation of neuron apoptotic process', 'positive regulation of synaptic transmission', 'presynaptic modulation of chemical synaptic transmission', 'receptor clustering', 'regulation of JNK cascade', 'regulation of long-term neuronal synaptic plasticity', 'regulation of membrane potential', 'regulation of short-term neuronal synaptic plasticity', 'synaptic transmission, glutamatergic']
Guanine nucleotide-binding protein G(t) subunit alpha-1
62
Guanine nucleotide-binding protein G(t) subunit alpha-1
210
8.1
65
0.19
P04695P04695['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell population proliferation', 'cellular response to electrical stimulus', 'detection of light stimulus involved in visual perception', 'eye photoreceptor cell development', 'G protein-coupled adenosine receptor signaling pathway', 'negative regulation of cyclic-nucleotide phosphodiesterase activity', 'phototransduction', 'phototransduction, visible light', 'response to light stimulus', 'retina development in camera-type eye', 'sensory perception of umami taste']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell population proliferation', 'cellular response to electrical stimulus', 'detection of light stimulus involved in visual perception', 'eye photoreceptor cell development', 'G protein-coupled adenosine receptor signaling pathway', 'negative regulation of cyclic-nucleotide phosphodiesterase activity', 'phototransduction', 'phototransduction, visible light', 'response to light stimulus', 'retina development in camera-type eye', 'sensory perception of umami taste']
ADP-sugar pyrophosphatase
76
ADP-sugar pyrophosphatase
126
9.8
67
0.15
Q9UKK9Q9UKK9['ATP generation from poly-ADP-D-ribose', 'chromatin remodeling', 'D-ribose catabolic process', 'nucleobase-containing small molecule metabolic process', 'nucleoside phosphate metabolic process', 'nucleotide metabolic process', 'ribonucleoside diphosphate catabolic process', 'ribose phosphate metabolic process']['ATP generation from poly-ADP-D-ribose', 'chromatin remodeling', 'D-ribose catabolic process', 'nucleobase-containing small molecule metabolic process', 'nucleoside phosphate metabolic process', 'nucleotide metabolic process', 'ribonucleoside diphosphate catabolic process', 'ribose phosphate metabolic process']
Trimethylguanosine synthase
745
Trimethylguanosine synthase
745
10.0
81
0.12
Q96RS0Q96RS0['7-methylguanosine cap hypermethylation', '7-methylguanosine RNA capping', 'ribonucleoprotein complex biogenesis', 'spliceosomal snRNP assembly']['7-methylguanosine cap hypermethylation', '7-methylguanosine RNA capping', 'ribonucleoprotein complex biogenesis', 'spliceosomal snRNP assembly']
Interferon alpha/beta receptor 2
207
Interferon alpha/beta receptor 2
227
8.9
78
0.14
P48551P48551['cell surface receptor signaling pathway', 'cellular response to virus', 'cytokine-mediated signaling pathway', 'defense response to virus', 'receptor signaling pathway via JAK-STAT', 'response to interferon-alpha', 'response to interferon-beta', 'response to virus', 'type I interferon signaling pathway']['cell surface receptor signaling pathway', 'cellular response to virus', 'cytokine-mediated signaling pathway', 'defense response to virus', 'receptor signaling pathway via JAK-STAT', 'response to interferon-alpha', 'response to interferon-beta', 'response to virus', 'type I interferon signaling pathway']
C-C motif chemokine 1
33
C-C motif chemokine 1
73
10.0
75
0.13
P22362P22362['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of inflammatory response', 'positive regulation of interleukin-17 production', 'positive regulation of monocyte chemotaxis', 'signal transduction', 'viral process']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of inflammatory response', 'positive regulation of interleukin-17 production', 'positive regulation of monocyte chemotaxis', 'signal transduction', 'viral process']
Isoform L-VEGF206 of Vascular endothelial growth factor A
257
Isoform L-VEGF206 of Vascular endothelial growth factor A
274
8.9
65
0.17
P15692-14P15692-14[][]
Serine protease 1
64
Pancreatic trypsin inhibitor
73
10.0
84
0.12
P07477P00974['digestion', 'extracellular matrix disassembly', 'proteolysis']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Fructose-bisphosphatase
129
Fructose-bisphosphatase
184
8.9
72
0.16
Q2TU34Q2TU34['gluconeogenesis']['gluconeogenesis']
Suppressor of tumorigenicity 14 protein
657
Kunitz-type protease inhibitor 1
259
8.1
101
0.12
Q9Y5Y6O43278['epithelial cell morphogenesis involved in placental branching', 'keratinocyte differentiation', 'neural tube closure', 'protein catabolic process', 'proteolysis']['branching involved in labyrinthine layer morphogenesis', 'cellular response to BMP stimulus', 'epidermis development', 'epithelium development', 'extracellular matrix organization', 'negative regulation of neural precursor cell proliferation', 'neural tube closure', 'placenta blood vessel development', 'positive regulation of glial cell differentiation']
C-C motif chemokine 13
58
C-C motif chemokine 13
58
8.8
52
0.22
Q99616Q99616['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytoskeleton organization', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'regulation of cell shape', 'signal transduction']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytoskeleton organization', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'regulation of cell shape', 'signal transduction']
Complement C5
728
Complement C5
702
8.1
73
0.17
P06684P06684['complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']['complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']
Collagen alpha-1(II) chain
86
Collagen alpha-1(II) chain
86
8.8
55
0.21
P02458P02458['anterior head development', 'cartilage condensation', 'cartilage development', 'cartilage development involved in endochondral bone morphogenesis', 'cellular response to BMP stimulus', 'central nervous system development', 'chondrocyte differentiation', 'collagen fibril organization', 'embryonic skeletal joint morphogenesis', 'endochondral ossification', 'extracellular matrix organization', 'extrinsic apoptotic signaling pathway in absence of ligand', 'heart morphogenesis', 'inner ear morphogenesis', 'limb bud formation', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'notochord development', 'otic vesicle development', 'proteoglycan metabolic process', 'regulation of gene expression', 'roof of mouth development', 'sensory perception of sound', 'skeletal system development', 'tissue homeostasis', 'visual perception']['anterior head development', 'cartilage condensation', 'cartilage development', 'cartilage development involved in endochondral bone morphogenesis', 'cellular response to BMP stimulus', 'central nervous system development', 'chondrocyte differentiation', 'collagen fibril organization', 'embryonic skeletal joint morphogenesis', 'endochondral ossification', 'extracellular matrix organization', 'extrinsic apoptotic signaling pathway in absence of ligand', 'heart morphogenesis', 'inner ear morphogenesis', 'limb bud formation', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'notochord development', 'otic vesicle development', 'proteoglycan metabolic process', 'regulation of gene expression', 'roof of mouth development', 'sensory perception of sound', 'skeletal system development', 'tissue homeostasis', 'visual perception']
Checkpoint protein HUS1
200
Cell cycle checkpoint protein RAD1
92
10.0
76
0.13
O60921O60671['cellular response to DNA damage stimulus', 'cellular response to ionizing radiation', 'DNA damage checkpoint signaling', 'DNA repair', 'double-strand break repair via homologous recombination', 'embryo development ending in birth or egg hatching', 'meiotic DNA integrity checkpoint signaling', 'mitotic DNA replication checkpoint signaling', 'mitotic intra-S DNA damage checkpoint signaling', 'nucleotide-excision repair', 'protein phosphorylation', 'regulation of protein phosphorylation', 'response to UV', 'telomere maintenance']['cellular response to DNA damage stimulus', 'cellular response to ionizing radiation', 'DNA damage checkpoint signaling', 'DNA repair', 'meiotic recombination checkpoint signaling', 'substantia nigra development']
Receptor-type tyrosine-protein phosphatase C
434
Receptor-type tyrosine-protein phosphatase C
434
8.9
57
0.2
P08575P08575['alpha-beta T cell proliferation', 'B cell differentiation', 'B cell proliferation', 'B cell receptor signaling pathway', 'bone marrow development', 'calcium-mediated signaling using intracellular calcium source', 'cell cycle phase transition', 'cell surface receptor signaling pathway', 'cellular response to extracellular stimulus', 'defense response to virus', 'dephosphorylation', 'DN2 thymocyte differentiation', 'extrinsic apoptotic signaling pathway', 'gamma-delta T cell differentiation', 'hematopoietic progenitor cell differentiation', 'heterotypic cell-cell adhesion', 'leukocyte cell-cell adhesion', 'MAPK cascade', 'natural killer cell differentiation', 'negative regulation of cell adhesion involved in substrate-bound cell migration', 'negative regulation of cytokine-mediated signaling pathway', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of interleukin-2 production', 'negative regulation of microglial cell activation', 'negative regulation of protein autophosphorylation', 'negative regulation of protein kinase activity', 'negative regulation of protein tyrosine kinase activity', 'negative regulation of T cell mediated cytotoxicity', 'negative thymic T cell selection', 'peptidyl-tyrosine phosphorylation', 'plasma membrane raft distribution', 'positive regulation of alpha-beta T cell proliferation', 'positive regulation of antigen receptor-mediated signaling pathway', 'positive regulation of B cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis', 'positive regulation of gamma-delta T cell differentiation', 'positive regulation of hematopoietic stem cell migration', 'positive regulation of humoral immune response mediated by circulating immunoglobulin', 'positive regulation of immunoglobulin production', 'positive regulation of interleukin-2 production', 'positive regulation of isotype switching to IgG isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase activity', 'positive regulation of protein tyrosine phosphatase activity', 'positive regulation of stem cell proliferation', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of T cell proliferation', 'positive regulation of tumor necrosis factor production', 'positive thymic T cell selection', 'protein autophosphorylation', 'protein dephosphorylation', 'regulation of cell cycle', 'regulation of gene expression', 'regulation of interleukin-8 production', 'regulation of phagocytosis', 'regulation of protein tyrosine kinase activity', 'regulation of receptor signaling pathway via JAK-STAT', 'release of sequestered calcium ion into cytosol', 'response to gamma radiation', 'stem cell development', 'T cell activation', 'T cell differentiation', 'T cell receptor signaling pathway']['alpha-beta T cell proliferation', 'B cell differentiation', 'B cell proliferation', 'B cell receptor signaling pathway', 'bone marrow development', 'calcium-mediated signaling using intracellular calcium source', 'cell cycle phase transition', 'cell surface receptor signaling pathway', 'cellular response to extracellular stimulus', 'defense response to virus', 'dephosphorylation', 'DN2 thymocyte differentiation', 'extrinsic apoptotic signaling pathway', 'gamma-delta T cell differentiation', 'hematopoietic progenitor cell differentiation', 'heterotypic cell-cell adhesion', 'leukocyte cell-cell adhesion', 'MAPK cascade', 'natural killer cell differentiation', 'negative regulation of cell adhesion involved in substrate-bound cell migration', 'negative regulation of cytokine-mediated signaling pathway', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of interleukin-2 production', 'negative regulation of microglial cell activation', 'negative regulation of protein autophosphorylation', 'negative regulation of protein kinase activity', 'negative regulation of protein tyrosine kinase activity', 'negative regulation of T cell mediated cytotoxicity', 'negative thymic T cell selection', 'peptidyl-tyrosine phosphorylation', 'plasma membrane raft distribution', 'positive regulation of alpha-beta T cell proliferation', 'positive regulation of antigen receptor-mediated signaling pathway', 'positive regulation of B cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis', 'positive regulation of gamma-delta T cell differentiation', 'positive regulation of hematopoietic stem cell migration', 'positive regulation of humoral immune response mediated by circulating immunoglobulin', 'positive regulation of immunoglobulin production', 'positive regulation of interleukin-2 production', 'positive regulation of isotype switching to IgG isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase activity', 'positive regulation of protein tyrosine phosphatase activity', 'positive regulation of stem cell proliferation', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of T cell proliferation', 'positive regulation of tumor necrosis factor production', 'positive thymic T cell selection', 'protein autophosphorylation', 'protein dephosphorylation', 'regulation of cell cycle', 'regulation of gene expression', 'regulation of interleukin-8 production', 'regulation of phagocytosis', 'regulation of protein tyrosine kinase activity', 'regulation of receptor signaling pathway via JAK-STAT', 'release of sequestered calcium ion into cytosol', 'response to gamma radiation', 'stem cell development', 'T cell activation', 'T cell differentiation', 'T cell receptor signaling pathway']
Pulmonary surfactant-associated protein B
298
Pulmonary surfactant-associated protein B
356
8.9
72
0.16
P50405P50405['respiratory gaseous exchange by respiratory system', 'sphingolipid metabolic process']['respiratory gaseous exchange by respiratory system', 'sphingolipid metabolic process']
E3 ubiquitin-protein ligase TRIM37
66
E3 ubiquitin-protein ligase TRIM37
66
8.1
72
0.17
O94972O94972['aggresome assembly', 'histone H2A monoubiquitination', 'histone H2A-K119 monoubiquitination', 'negative regulation of centriole replication', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of NF-kappaB transcription factor activity', 'protein autoubiquitination']['aggresome assembly', 'histone H2A monoubiquitination', 'histone H2A-K119 monoubiquitination', 'negative regulation of centriole replication', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of NF-kappaB transcription factor activity', 'protein autoubiquitination']
Protocadherin-15
268
Protocadherin-15
268
8.1
67
0.18
Q96QU1Q96QU1['cell adhesion', 'equilibrioception', 'homophilic cell adhesion via plasma membrane adhesion molecules', 'inner ear development', 'photoreceptor cell maintenance', 'sensory perception of light stimulus', 'sensory perception of sound']['cell adhesion', 'equilibrioception', 'homophilic cell adhesion via plasma membrane adhesion molecules', 'inner ear development', 'photoreceptor cell maintenance', 'sensory perception of light stimulus', 'sensory perception of sound']
Tumor protein p73
262
Tumor protein p73
194
10.0
63
0.16
O15350O15350['cell cycle', 'cellular response to DNA damage stimulus', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'kidney development', 'mismatch repair', 'negative regulation of cardiac muscle cell proliferation', 'negative regulation of cell population proliferation', 'negative regulation of neuron differentiation', 'positive regulation of apoptotic process', 'positive regulation of lung ciliated cell differentiation', 'positive regulation of MAPK cascade', 'positive regulation of oligodendrocyte differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein tetramerization', 'regulation of cell cycle', 'regulation of gene expression', 'regulation of mitotic cell cycle', 'regulation of transcription by RNA polymerase II', 'response to organonitrogen compound', 'response to xenobiotic stimulus']['cell cycle', 'cellular response to DNA damage stimulus', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'kidney development', 'mismatch repair', 'negative regulation of cardiac muscle cell proliferation', 'negative regulation of cell population proliferation', 'negative regulation of neuron differentiation', 'positive regulation of apoptotic process', 'positive regulation of lung ciliated cell differentiation', 'positive regulation of MAPK cascade', 'positive regulation of oligodendrocyte differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein tetramerization', 'regulation of cell cycle', 'regulation of gene expression', 'regulation of mitotic cell cycle', 'regulation of transcription by RNA polymerase II', 'response to organonitrogen compound', 'response to xenobiotic stimulus']
Growth/differentiation factor 5
433
Growth/differentiation factor 5
465
8.2
79
0.15
P43026P43026['BMP signaling pathway', 'cell-cell signaling', 'chondroblast differentiation', 'chondrocyte differentiation', 'embryonic limb morphogenesis', 'forelimb morphogenesis', 'hindlimb morphogenesis', 'mesenchymal cell apoptotic process', 'negative regulation of chondrocyte differentiation', 'negative regulation of epithelial cell proliferation', 'negative regulation of mesenchymal cell apoptotic process', 'negative regulation of neuron apoptotic process', 'ossification involved in bone remodeling', 'positive regulation of BMP signaling pathway', 'positive regulation of chondrocyte differentiation', 'positive regulation of neuron differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'regulation of multicellular organism growth', 'regulation of SMAD protein signal transduction', 'response to mechanical stimulus', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['BMP signaling pathway', 'cell-cell signaling', 'chondroblast differentiation', 'chondrocyte differentiation', 'embryonic limb morphogenesis', 'forelimb morphogenesis', 'hindlimb morphogenesis', 'mesenchymal cell apoptotic process', 'negative regulation of chondrocyte differentiation', 'negative regulation of epithelial cell proliferation', 'negative regulation of mesenchymal cell apoptotic process', 'negative regulation of neuron apoptotic process', 'ossification involved in bone remodeling', 'positive regulation of BMP signaling pathway', 'positive regulation of chondrocyte differentiation', 'positive regulation of neuron differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'regulation of multicellular organism growth', 'regulation of SMAD protein signal transduction', 'response to mechanical stimulus', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
Mitogen-activated protein kinase kinase kinase kinase 4
202
Mitogen-activated protein kinase kinase kinase kinase 4
202
8.8
59
0.19
O95819O95819['intracellular signal transduction', 'MAPK cascade', 'negative regulation of apoptotic process', 'negative regulation of cell-matrix adhesion', 'neuron projection morphogenesis', 'positive regulation of ARF protein signal transduction', 'positive regulation of cell migration', 'positive regulation of focal adhesion assembly', 'positive regulation of focal adhesion disassembly', 'positive regulation of GTPase activity', 'positive regulation of keratinocyte migration', 'protein phosphorylation', 'regulation of JNK cascade', 'regulation of MAPK cascade']['intracellular signal transduction', 'MAPK cascade', 'negative regulation of apoptotic process', 'negative regulation of cell-matrix adhesion', 'neuron projection morphogenesis', 'positive regulation of ARF protein signal transduction', 'positive regulation of cell migration', 'positive regulation of focal adhesion assembly', 'positive regulation of focal adhesion disassembly', 'positive regulation of GTPase activity', 'positive regulation of keratinocyte migration', 'protein phosphorylation', 'regulation of JNK cascade', 'regulation of MAPK cascade']
NAD-capped RNA hydrolase NUDT12
387
NAD-capped RNA hydrolase NUDT12
400
8.8
74
0.15
Q9DCN1Q9DCN1['circadian regulation of gene expression', 'methylguanosine-cap decapping', 'mRNA catabolic process', 'NAD catabolic process', 'NAD-cap decapping', 'NADH metabolic process', 'NADP catabolic process']['circadian regulation of gene expression', 'methylguanosine-cap decapping', 'mRNA catabolic process', 'NAD catabolic process', 'NAD-cap decapping', 'NADH metabolic process', 'NADP catabolic process']
Oxytocin-neurophysin 1
110
Oxytocin-neurophysin 1
110
8.2
98
0.12
P01175P01175['positive regulation of cold-induced thermogenesis', 'response to estrogen', 'response to external biotic stimulus', 'response to food', 'response to mechanical stimulus']['positive regulation of cold-induced thermogenesis', 'response to estrogen', 'response to external biotic stimulus', 'response to food', 'response to mechanical stimulus']
Antiviral innate immune response receptor RIG-I
136
Mitochondrial antiviral-signaling protein
13
8.2
70
0.17
O95786Q7Z434['antiviral innate immune response', 'cellular response to exogenous dsRNA', 'cytoplasmic pattern recognition receptor signaling pathway in response to virus', 'defense response to virus', 'detection of virus', 'gene expression', 'innate immune response', 'positive regulation of defense response to virus by host', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of gene expression', 'positive regulation of granulocyte macrophage colony-stimulating factor production', 'positive regulation of interferon-alpha production', 'positive regulation of interferon-beta production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of myeloid dendritic cell cytokine production', 'positive regulation of response to cytokine stimulus', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'regulation of cell migration', 'regulation of type III interferon production', 'response to exogenous dsRNA', 'response to virus', 'RIG-I signaling pathway']['activation of innate immune response', 'cellular response to exogenous dsRNA', 'defense response to bacterium', 'defense response to virus', 'innate immune response', 'negative regulation of viral genome replication', 'positive regulation of chemokine (C-C motif) ligand 5 production', 'positive regulation of defense response to virus by host', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interferon-alpha production', 'positive regulation of interferon-beta production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of IP-10 production', 'positive regulation of myeloid dendritic cell cytokine production', 'positive regulation of protein import into nucleus', 'positive regulation of protein phosphorylation', 'positive regulation of response to cytokine stimulus', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'positive regulation of type I interferon-mediated signaling pathway', 'regulation of peroxisome organization', 'signal transduction', 'type I interferon signaling pathway']
Glutamate receptor 1
75
Glutamate receptor 1
75
8.2
77
0.16
P19490P19490['cellular response to amine stimulus', 'cellular response to amino acid stimulus', 'cellular response to ammonium ion', 'cellular response to dsRNA', 'cellular response to growth factor stimulus', 'cellular response to organic cyclic compound', 'cellular response to peptide hormone stimulus', 'chemical synaptic transmission', 'long-term memory', 'long-term synaptic depression', 'modulation of chemical synaptic transmission', 'neuronal action potential', 'positive regulation of membrane potential', 'positive regulation of synaptic transmission', 'receptor internalization', 'regulation of postsynaptic membrane potential', 'regulation of receptor recycling', 'regulation of synaptic plasticity', 'response to arsenic-containing substance', 'response to cocaine', 'response to electrical stimulus', 'response to estradiol', 'response to fungicide', 'response to lithium ion', 'response to organic cyclic compound', 'response to peptide hormone', 'response to toxic substance', 'response to xenobiotic stimulus', 'spinal cord development', 'synaptic transmission, glutamatergic']['cellular response to amine stimulus', 'cellular response to amino acid stimulus', 'cellular response to ammonium ion', 'cellular response to dsRNA', 'cellular response to growth factor stimulus', 'cellular response to organic cyclic compound', 'cellular response to peptide hormone stimulus', 'chemical synaptic transmission', 'long-term memory', 'long-term synaptic depression', 'modulation of chemical synaptic transmission', 'neuronal action potential', 'positive regulation of membrane potential', 'positive regulation of synaptic transmission', 'receptor internalization', 'regulation of postsynaptic membrane potential', 'regulation of receptor recycling', 'regulation of synaptic plasticity', 'response to arsenic-containing substance', 'response to cocaine', 'response to electrical stimulus', 'response to estradiol', 'response to fungicide', 'response to lithium ion', 'response to organic cyclic compound', 'response to peptide hormone', 'response to toxic substance', 'response to xenobiotic stimulus', 'spinal cord development', 'synaptic transmission, glutamatergic']
F-box-like/WD repeat-containing protein TBL1XR1
330
F-box-like/WD repeat-containing protein TBL1XR1
434
8.7
77
0.15
Q8BHJ5Q8BHJ5['adipose tissue development', 'blastocyst hatching', 'chromatin organization', 'fat pad development', 'histone deacetylation', 'lipid catabolic process', 'multicellular organism growth', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'regulation of gene expression', 'regulation of transcription by RNA polymerase II', 'regulation of triglyceride metabolic process', 'response to dietary excess', 'white fat cell differentiation']['adipose tissue development', 'blastocyst hatching', 'chromatin organization', 'fat pad development', 'histone deacetylation', 'lipid catabolic process', 'multicellular organism growth', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'regulation of gene expression', 'regulation of transcription by RNA polymerase II', 'regulation of triglyceride metabolic process', 'response to dietary excess', 'white fat cell differentiation']
Fatty acid synthase
2292
Fatty acid synthase
2292
8.9
71
0.16
P49327P49327['cellular response to interleukin-4', 'establishment of endothelial intestinal barrier', 'ether lipid biosynthetic process', 'fatty acid biosynthetic process', 'fatty acid metabolic process', 'glandular epithelial cell development', 'inflammatory response', 'mammary gland development', 'monocyte differentiation', 'neutrophil differentiation', 'osteoblast differentiation']['cellular response to interleukin-4', 'establishment of endothelial intestinal barrier', 'ether lipid biosynthetic process', 'fatty acid biosynthetic process', 'fatty acid metabolic process', 'glandular epithelial cell development', 'inflammatory response', 'mammary gland development', 'monocyte differentiation', 'neutrophil differentiation', 'osteoblast differentiation']
WD repeat-containing protein 48
200
WD repeat-containing protein 48
200
8.8
65
0.18
Q8TAF3Q8TAF3['cellular response to DNA damage stimulus', 'double-strand break repair via homologous recombination', 'embryonic organ development', 'homeostasis of number of cells', 'multicellular organism growth', 'positive regulation of double-strand break repair via homologous recombination', 'positive regulation of epithelial cell proliferation', 'protein deubiquitination', 'regulation of protein monoubiquitination', 'seminiferous tubule development', 'single fertilization', 'skeletal system morphogenesis', 'skin development', 'spermatogenesis']['cellular response to DNA damage stimulus', 'double-strand break repair via homologous recombination', 'embryonic organ development', 'homeostasis of number of cells', 'multicellular organism growth', 'positive regulation of double-strand break repair via homologous recombination', 'positive regulation of epithelial cell proliferation', 'protein deubiquitination', 'regulation of protein monoubiquitination', 'seminiferous tubule development', 'single fertilization', 'skeletal system morphogenesis', 'skin development', 'spermatogenesis']
Isovaleryl-CoA dehydrogenase, mitochondrial
370
Isovaleryl-CoA dehydrogenase, mitochondrial
370
8.7
81
0.14
P26440P26440['branched-chain amino acid catabolic process', 'fatty acid beta-oxidation using acyl-CoA dehydrogenase', 'leucine catabolic process']['branched-chain amino acid catabolic process', 'fatty acid beta-oxidation using acyl-CoA dehydrogenase', 'leucine catabolic process']
NAD(P)H-hydrate epimerase
277
NAD(P)H-hydrate epimerase
277
8.1
82
0.15
Q8K4Z3Q8K4Z3['lipid transport', 'membrane raft distribution', 'negative regulation of angiogenesis', 'nicotinamide nucleotide metabolic process', 'regulation of cholesterol efflux', 'sprouting angiogenesis']['lipid transport', 'membrane raft distribution', 'negative regulation of angiogenesis', 'nicotinamide nucleotide metabolic process', 'regulation of cholesterol efflux', 'sprouting angiogenesis']
E3 ubiquitin-protein ligase parkin
337
E3 ubiquitin-protein ligase parkin
323
8.7
69
0.17
Q9JK66Q9JK66['adult locomotory behavior', 'aggresome assembly', 'autophagy of mitochondrion', 'brain development', 'cellular response to hydrogen sulfide', 'cellular response to L-glutamate', 'cellular response to L-glutamine', 'cellular response to manganese ion', 'cellular response to toxic substance', 'dopamine metabolic process', 'dopamine uptake involved in synaptic transmission', 'free ubiquitin chain polymerization', 'learning', 'locomotory behavior', 'mitochondrial fission', 'mitochondrial fragmentation involved in apoptotic process', 'mitochondrion localization', 'mitochondrion organization', 'mitochondrion to lysosome transport', 'mitophagy', 'modulation of chemical synaptic transmission', 'negative regulation by host of viral genome replication', 'negative regulation of actin filament bundle assembly', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell death', 'negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of excitatory postsynaptic potential', 'negative regulation of exosomal secretion', 'negative regulation of gene expression', 'negative regulation of glucokinase activity', 'negative regulation of insulin secretion', 'negative regulation of intralumenal vesicle formation', 'negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'negative regulation of JNK cascade', 'negative regulation of mitochondrial fission', 'negative regulation of mitochondrial fusion', 'negative regulation of neuron apoptotic process', 'negative regulation of neuron death', 'negative regulation of oxidative stress-induced neuron death', 'negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of primary amine oxidase activity', 'negative regulation of protein phosphorylation', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of release of cytochrome c from mitochondria', 'negative regulation of spontaneous neurotransmitter secretion', 'negative regulation of synaptic transmission, glutamatergic', 'negative regulation of transcription by RNA polymerase II', 'neuron cellular homeostasis', 'norepinephrine metabolic process', 'parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization', 'positive regulation of apoptotic process', 'positive regulation of ATP biosynthetic process', 'positive regulation of autophagy of mitochondrion', 'positive regulation of dendrite extension', 'positive regulation of DNA binding', 'positive regulation of gene expression', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of mitochondrial fission', 'positive regulation of mitochondrial fusion', 'positive regulation of mitochondrial membrane potential', 'positive regulation of mitophagy', 'positive regulation of mitophagy in response to mitochondrial depolarization', 'positive regulation of neurotransmitter uptake', 'positive regulation of proteasomal protein catabolic process', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of protein binding', 'positive regulation of protein linear polyubiquitination', 'positive regulation of protein localization to membrane', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor-mediated signaling pathway', 'proteasomal protein catabolic process', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein autoubiquitination', 'protein destabilization', 'protein K11-linked ubiquitination', 'protein K48-linked ubiquitination', 'protein K6-linked ubiquitination', 'protein K63-linked ubiquitination', 'protein localization to mitochondrion', 'protein metabolic process', 'protein monoubiquitination', 'protein polyubiquitination', 'protein stabilization', 'protein ubiquitination', 'regulation of apoptotic process', 'regulation of autophagy', 'regulation of cellular response to oxidative stress', 'regulation of dopamine metabolic process', 'regulation of gene expression', 'regulation of mitochondrial membrane potential', 'regulation of mitochondrion organization', 'regulation of neurotransmitter secretion', 'regulation of protein stability', 'regulation of protein ubiquitination', 'regulation of reactive oxygen species metabolic process', 'response to corticosterone', 'response to curcumin', 'response to endoplasmic reticulum stress', 'response to muscle activity', 'response to oxidative stress', 'response to unfolded protein', 'response to xenobiotic stimulus', 'startle response', 'synaptic transmission, dopaminergic', 'synaptic transmission, glutamatergic', 'ubiquitin-dependent protein catabolic process', 'zinc ion homeostasis']['adult locomotory behavior', 'aggresome assembly', 'autophagy of mitochondrion', 'brain development', 'cellular response to hydrogen sulfide', 'cellular response to L-glutamate', 'cellular response to L-glutamine', 'cellular response to manganese ion', 'cellular response to toxic substance', 'dopamine metabolic process', 'dopamine uptake involved in synaptic transmission', 'free ubiquitin chain polymerization', 'learning', 'locomotory behavior', 'mitochondrial fission', 'mitochondrial fragmentation involved in apoptotic process', 'mitochondrion localization', 'mitochondrion organization', 'mitochondrion to lysosome transport', 'mitophagy', 'modulation of chemical synaptic transmission', 'negative regulation by host of viral genome replication', 'negative regulation of actin filament bundle assembly', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell death', 'negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of excitatory postsynaptic potential', 'negative regulation of exosomal secretion', 'negative regulation of gene expression', 'negative regulation of glucokinase activity', 'negative regulation of insulin secretion', 'negative regulation of intralumenal vesicle formation', 'negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'negative regulation of JNK cascade', 'negative regulation of mitochondrial fission', 'negative regulation of mitochondrial fusion', 'negative regulation of neuron apoptotic process', 'negative regulation of neuron death', 'negative regulation of oxidative stress-induced neuron death', 'negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of primary amine oxidase activity', 'negative regulation of protein phosphorylation', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of release of cytochrome c from mitochondria', 'negative regulation of spontaneous neurotransmitter secretion', 'negative regulation of synaptic transmission, glutamatergic', 'negative regulation of transcription by RNA polymerase II', 'neuron cellular homeostasis', 'norepinephrine metabolic process', 'parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization', 'positive regulation of apoptotic process', 'positive regulation of ATP biosynthetic process', 'positive regulation of autophagy of mitochondrion', 'positive regulation of dendrite extension', 'positive regulation of DNA binding', 'positive regulation of gene expression', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of mitochondrial fission', 'positive regulation of mitochondrial fusion', 'positive regulation of mitochondrial membrane potential', 'positive regulation of mitophagy', 'positive regulation of mitophagy in response to mitochondrial depolarization', 'positive regulation of neurotransmitter uptake', 'positive regulation of proteasomal protein catabolic process', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of protein binding', 'positive regulation of protein linear polyubiquitination', 'positive regulation of protein localization to membrane', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor-mediated signaling pathway', 'proteasomal protein catabolic process', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein autoubiquitination', 'protein destabilization', 'protein K11-linked ubiquitination', 'protein K48-linked ubiquitination', 'protein K6-linked ubiquitination', 'protein K63-linked ubiquitination', 'protein localization to mitochondrion', 'protein metabolic process', 'protein monoubiquitination', 'protein polyubiquitination', 'protein stabilization', 'protein ubiquitination', 'regulation of apoptotic process', 'regulation of autophagy', 'regulation of cellular response to oxidative stress', 'regulation of dopamine metabolic process', 'regulation of gene expression', 'regulation of mitochondrial membrane potential', 'regulation of mitochondrion organization', 'regulation of neurotransmitter secretion', 'regulation of protein stability', 'regulation of protein ubiquitination', 'regulation of reactive oxygen species metabolic process', 'response to corticosterone', 'response to curcumin', 'response to endoplasmic reticulum stress', 'response to muscle activity', 'response to oxidative stress', 'response to unfolded protein', 'response to xenobiotic stimulus', 'startle response', 'synaptic transmission, dopaminergic', 'synaptic transmission, glutamatergic', 'ubiquitin-dependent protein catabolic process', 'zinc ion homeostasis']
Galectin-1
131
Galectin-1
131
8.2
62
0.2
P09382P09382['apoptotic process', 'cell-cell adhesion', 'myoblast differentiation', 'plasma cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of inflammatory response', 'positive regulation of viral entry into host cell', 'regulation of apoptotic process', 'T cell costimulation']['apoptotic process', 'cell-cell adhesion', 'myoblast differentiation', 'plasma cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of inflammatory response', 'positive regulation of viral entry into host cell', 'regulation of apoptotic process', 'T cell costimulation']
Twinfilin-1
42
Twinfilin-1
42
8.8
81
0.14
Q91YR1Q91YR1['actin filament depolymerization', 'barbed-end actin filament capping', 'negative regulation of actin filament polymerization', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of neuron projection development', 'regulation of actin phosphorylation', 'regulation of lamellipodium assembly', 'sequestering of actin monomers']['actin filament depolymerization', 'barbed-end actin filament capping', 'negative regulation of actin filament polymerization', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of neuron projection development', 'regulation of actin phosphorylation', 'regulation of lamellipodium assembly', 'sequestering of actin monomers']
PRSS3 protein
68
Amyloid beta precursor like protein 2
343
8.1
78
0.16
Q8N2U3Q06481['proteolysis']['axonogenesis', 'central nervous system development', 'G protein-coupled receptor signaling pathway', 'regulation of cellular protein metabolic process']
Gamma-crystallin S
27
Gamma-crystallin S
25
8.8
65
0.18
P22914P22914['lens development in camera-type eye', 'morphogenesis of an epithelium', 'visual perception']['lens development in camera-type eye', 'morphogenesis of an epithelium', 'visual perception']
E3 ubiquitin-protein ligase RNF13
258
E3 ubiquitin-protein ligase RNF13
266
8.8
63
0.18
O43567O43567['organelle localization', 'positive regulation of stress-activated protein kinase signaling cascade', 'protein autoubiquitination', 'ubiquitin-dependent protein catabolic process']['organelle localization', 'positive regulation of stress-activated protein kinase signaling cascade', 'protein autoubiquitination', 'ubiquitin-dependent protein catabolic process']
Transforming growth factor beta-1 proprotein
355
Transforming growth factor beta-1 proprotein
293
10.0
75
0.13
P07200P07200['adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains', 'aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'branch elongation involved in mammary gland duct branching', 'bronchiole development', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'cellular calcium ion homeostasis', 'cellular response to ionizing radiation', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'chondrocyte differentiation', 'columnar/cuboidal epithelial cell maturation', 'common-partner SMAD protein phosphorylation', 'embryonic liver development', 'enamel mineralization', 'endoderm development', 'epidermal growth factor receptor signaling pathway', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'face morphogenesis', 'gene expression', 'germ cell migration', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'Langerhans cell differentiation', 'lens fiber cell differentiation', 'lipopolysaccharide-mediated signaling pathway', 'lung alveolus development', 'lymph node development', 'mammary gland branching involved in thelarche', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'muscle cell cellular homeostasis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of epithelial cell proliferation', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of interleukin-17 production', 'negative regulation of macrophage cytokine production', 'negative regulation of myoblast differentiation', 'negative regulation of ossification', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of T cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'Notch signaling pathway', 'oligodendrocyte development', 'ossification involved in bone remodeling', 'osteoclast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'phospholipid homeostasis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of histone acetylation', 'positive regulation of histone deacetylation', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of odontogenesis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor clustering', 'positive regulation of regulatory T cell differentiation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stem cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of actin cytoskeleton reorganization', 'regulation of binding', 'regulation of branching involved in mammary gland duct morphogenesis', 'regulation of cartilage development', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of interleukin-23 production', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of sodium ion transport', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulatory T cell differentiation', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'stem cell proliferation', 'surfactant homeostasis', 'T cell homeostasis', 'T cell proliferation', 'tolerance induction to self antigen', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'ureteric bud development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains', 'aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'branch elongation involved in mammary gland duct branching', 'bronchiole development', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'cellular calcium ion homeostasis', 'cellular response to ionizing radiation', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'chondrocyte differentiation', 'columnar/cuboidal epithelial cell maturation', 'common-partner SMAD protein phosphorylation', 'embryonic liver development', 'enamel mineralization', 'endoderm development', 'epidermal growth factor receptor signaling pathway', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'face morphogenesis', 'gene expression', 'germ cell migration', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'Langerhans cell differentiation', 'lens fiber cell differentiation', 'lipopolysaccharide-mediated signaling pathway', 'lung alveolus development', 'lymph node development', 'mammary gland branching involved in thelarche', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'muscle cell cellular homeostasis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of epithelial cell proliferation', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of interleukin-17 production', 'negative regulation of macrophage cytokine production', 'negative regulation of myoblast differentiation', 'negative regulation of ossification', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of T cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'Notch signaling pathway', 'oligodendrocyte development', 'ossification involved in bone remodeling', 'osteoclast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'phospholipid homeostasis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of histone acetylation', 'positive regulation of histone deacetylation', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of odontogenesis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor clustering', 'positive regulation of regulatory T cell differentiation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stem cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of actin cytoskeleton reorganization', 'regulation of binding', 'regulation of branching involved in mammary gland duct morphogenesis', 'regulation of cartilage development', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of interleukin-23 production', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of sodium ion transport', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulatory T cell differentiation', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'stem cell proliferation', 'surfactant homeostasis', 'T cell homeostasis', 'T cell proliferation', 'tolerance induction to self antigen', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'ureteric bud development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']
Bone morphogenetic protein 3
436
Bone morphogenetic protein 3
370
8.2
79
0.15
P12645P12645['cartilage development', 'cell-cell signaling', 'osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'skeletal system development', 'SMAD protein signal transduction']['cartilage development', 'cell-cell signaling', 'osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'skeletal system development', 'SMAD protein signal transduction']
DNA (cytosine-5)-methyltransferase 3A
559
DNA (cytosine-5)-methyltransferase 3A
514
8.1
81
0.15
Q9Y6K1Q9Y6K1['aging', 'C-5 methylation of cytosine', 'cellular response to amino acid stimulus', 'cellular response to bisphenol A', 'cellular response to ethanol', 'cellular response to hypoxia', 'DNA methylation', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'DNA methylation on cytosine', 'DNA methylation-dependent heterochromatin assembly', 'hepatocyte apoptotic process', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron differentiation', 'positive regulation of cell death', 'regulation of gene expression by genomic imprinting', 'response to cocaine', 'response to estradiol', 'response to ionizing radiation', 'response to lead ion', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'spermatogenesis']['aging', 'C-5 methylation of cytosine', 'cellular response to amino acid stimulus', 'cellular response to bisphenol A', 'cellular response to ethanol', 'cellular response to hypoxia', 'DNA methylation', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'DNA methylation on cytosine', 'DNA methylation-dependent heterochromatin assembly', 'hepatocyte apoptotic process', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron differentiation', 'positive regulation of cell death', 'regulation of gene expression by genomic imprinting', 'response to cocaine', 'response to estradiol', 'response to ionizing radiation', 'response to lead ion', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'spermatogenesis']
Pleckstrin homology domain-containing family A member 7
193
Pleckstrin homology domain-containing family A member 7
193
8.7
87
0.13
Q6IQ23Q6IQ23['cell-cell adhesion mediated by cadherin', 'epithelial cell-cell adhesion', 'pore complex assembly', 'zonula adherens maintenance']['cell-cell adhesion mediated by cadherin', 'epithelial cell-cell adhesion', 'pore complex assembly', 'zonula adherens maintenance']
DNA (cytosine-5)-methyltransferase 3A
559
DNA (cytosine-5)-methyltransferase 3A
497
8.2
85
0.14
Q9Y6K1Q9Y6K1['aging', 'C-5 methylation of cytosine', 'cellular response to amino acid stimulus', 'cellular response to bisphenol A', 'cellular response to ethanol', 'cellular response to hypoxia', 'DNA methylation', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'DNA methylation on cytosine', 'DNA methylation-dependent heterochromatin assembly', 'hepatocyte apoptotic process', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron differentiation', 'positive regulation of cell death', 'regulation of gene expression by genomic imprinting', 'response to cocaine', 'response to estradiol', 'response to ionizing radiation', 'response to lead ion', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'spermatogenesis']['aging', 'C-5 methylation of cytosine', 'cellular response to amino acid stimulus', 'cellular response to bisphenol A', 'cellular response to ethanol', 'cellular response to hypoxia', 'DNA methylation', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'DNA methylation on cytosine', 'DNA methylation-dependent heterochromatin assembly', 'hepatocyte apoptotic process', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron differentiation', 'positive regulation of cell death', 'regulation of gene expression by genomic imprinting', 'response to cocaine', 'response to estradiol', 'response to ionizing radiation', 'response to lead ion', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'spermatogenesis']
Glutathione S-transferase Mu 4
78
Glutathione S-transferase Mu 4
78
8.2
79
0.15
Q03013Q03013['glutathione metabolic process', 'long-chain fatty acid biosynthetic process', 'nitrobenzene metabolic process', 'xenobiotic catabolic process']['glutathione metabolic process', 'long-chain fatty acid biosynthetic process', 'nitrobenzene metabolic process', 'xenobiotic catabolic process']
Neuroblastoma suppressor of tumorigenicity 1
63
Neuroblastoma suppressor of tumorigenicity 1
63
10.0
80
0.13
P41271P41271['animal organ morphogenesis', 'determination of dorsal identity', 'negative regulation of BMP signaling pathway', 'negative regulation of monocyte chemotaxis', 'nervous system development', 'neuron projection morphogenesis', 'positive regulation of neuron differentiation', 'sequestering of BMP from receptor via BMP binding', 'sequestering of BMP in extracellular matrix']['animal organ morphogenesis', 'determination of dorsal identity', 'negative regulation of BMP signaling pathway', 'negative regulation of monocyte chemotaxis', 'nervous system development', 'neuron projection morphogenesis', 'positive regulation of neuron differentiation', 'sequestering of BMP from receptor via BMP binding', 'sequestering of BMP in extracellular matrix']
Tumor necrosis factor receptor superfamily member 4
87
Tumor necrosis factor receptor superfamily member 4
43
9.9
75
0.14
P43489P43489['immune response', 'inflammatory response', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of transcription, DNA-templated', 'positive regulation of B cell proliferation', 'positive regulation of immunoglobulin production', 'T cell proliferation']['immune response', 'inflammatory response', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of transcription, DNA-templated', 'positive regulation of B cell proliferation', 'positive regulation of immunoglobulin production', 'T cell proliferation']
Androgen receptor
578
Androgen receptor
584
8.2
65
0.19
P15207P15207['activation of prostate induction by androgen receptor signaling pathway', 'androgen receptor signaling pathway', 'animal organ formation', 'cellular response to estrogen stimulus', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to testosterone stimulus', 'copulation', 'epithelial cell differentiation involved in prostate gland development', 'epithelial cell morphogenesis', 'fertilization', 'in utero embryonic development', 'intracellular estrogen receptor signaling pathway', 'intracellular receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lateral sprouting involved in mammary gland duct morphogenesis', 'Leydig cell differentiation', 'male courtship behavior', 'male genitalia morphogenesis', 'male gonad development', 'male sex differentiation', 'male somatic sex determination', 'mammary gland alveolus development', 'morphogenesis of an epithelial fold', 'multicellular organism growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of integrin biosynthetic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell proliferation involved in prostate gland development', 'positive regulation of gene expression', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of integrin biosynthetic process', 'positive regulation of intracellular estrogen receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of penile erection', 'positive regulation of phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase III', 'positive regulation of transcription, DNA-templated', 'prostate gland epithelium morphogenesis', 'prostate gland growth', 'regulation of developmental growth', 'regulation of gene expression', 'regulation of prostatic bud formation', 'regulation of protein localization to plasma membrane', 'regulation of systemic arterial blood pressure', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'reproductive behavior', 'reproductive structure development', 'reproductive system development', 'response to estradiol', 'response to insulin', 'response to testosterone', 'seminiferous tubule development', 'single fertilization', 'skeletal muscle hypertrophy', 'spermatogenesis', 'tertiary branching involved in mammary gland duct morphogenesis']['activation of prostate induction by androgen receptor signaling pathway', 'androgen receptor signaling pathway', 'animal organ formation', 'cellular response to estrogen stimulus', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to testosterone stimulus', 'copulation', 'epithelial cell differentiation involved in prostate gland development', 'epithelial cell morphogenesis', 'fertilization', 'in utero embryonic development', 'intracellular estrogen receptor signaling pathway', 'intracellular receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lateral sprouting involved in mammary gland duct morphogenesis', 'Leydig cell differentiation', 'male courtship behavior', 'male genitalia morphogenesis', 'male gonad development', 'male sex differentiation', 'male somatic sex determination', 'mammary gland alveolus development', 'morphogenesis of an epithelial fold', 'multicellular organism growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of integrin biosynthetic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell proliferation involved in prostate gland development', 'positive regulation of gene expression', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of integrin biosynthetic process', 'positive regulation of intracellular estrogen receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of penile erection', 'positive regulation of phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase III', 'positive regulation of transcription, DNA-templated', 'prostate gland epithelium morphogenesis', 'prostate gland growth', 'regulation of developmental growth', 'regulation of gene expression', 'regulation of prostatic bud formation', 'regulation of protein localization to plasma membrane', 'regulation of systemic arterial blood pressure', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'reproductive behavior', 'reproductive structure development', 'reproductive system development', 'response to estradiol', 'response to insulin', 'response to testosterone', 'seminiferous tubule development', 'single fertilization', 'skeletal muscle hypertrophy', 'spermatogenesis', 'tertiary branching involved in mammary gland duct morphogenesis']
Prosaposin
66
Prosaposin
66
10.0
81
0.12
Q61207Q61207['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'antigen processing and presentation', 'cellular response to organic substance', 'ceramide metabolic process', 'cerebellar Purkinje cell differentiation', 'cochlea development', 'corneocyte development', 'cornified envelope assembly', 'developmental growth', 'epithelial cell differentiation involved in prostate gland development', 'galactosylceramide catabolic process', 'ganglioside GM1 transport to membrane', 'gene expression', 'glucosylceramide metabolic process', 'glycolipid metabolic process', 'inclusion body assembly', 'intracellular protein transport', 'lysosomal protein catabolic process', 'lysosomal transport', 'membrane lipid metabolic process', 'micturition', 'myelination', 'negative regulation of hydrogen peroxide-induced cell death', 'nervous system process', 'neuromuscular process controlling balance', 'NK T cell differentiation', 'positive regulation of beta-galactosidase activity', 'positive regulation of hydrolase activity', 'positive regulation of MAPK cascade', 'prostate gland growth', 'protein secretion', 'regulation of lipid metabolic process', 'regulation of MAPK cascade', 'sensory perception of sound', 'sphingolipid metabolic process', 'walking behavior']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'antigen processing and presentation', 'cellular response to organic substance', 'ceramide metabolic process', 'cerebellar Purkinje cell differentiation', 'cochlea development', 'corneocyte development', 'cornified envelope assembly', 'developmental growth', 'epithelial cell differentiation involved in prostate gland development', 'galactosylceramide catabolic process', 'ganglioside GM1 transport to membrane', 'gene expression', 'glucosylceramide metabolic process', 'glycolipid metabolic process', 'inclusion body assembly', 'intracellular protein transport', 'lysosomal protein catabolic process', 'lysosomal transport', 'membrane lipid metabolic process', 'micturition', 'myelination', 'negative regulation of hydrogen peroxide-induced cell death', 'nervous system process', 'neuromuscular process controlling balance', 'NK T cell differentiation', 'positive regulation of beta-galactosidase activity', 'positive regulation of hydrolase activity', 'positive regulation of MAPK cascade', 'prostate gland growth', 'protein secretion', 'regulation of lipid metabolic process', 'regulation of MAPK cascade', 'sensory perception of sound', 'sphingolipid metabolic process', 'walking behavior']
Inhibin beta A chain
350
Inhibin beta A chain
390
9.9
73
0.14
P08476P08476['activin receptor signaling pathway', 'cell differentiation', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular response to cholesterol', 'cellular response to follicle-stimulating hormone stimulus', 'defense response', 'endodermal cell differentiation', 'erythrocyte differentiation', 'extrinsic apoptotic signaling pathway', 'eyelid development in camera-type eye', 'GABAergic neuron differentiation', 'hair follicle development', 'hematopoietic progenitor cell differentiation', 'hemoglobin biosynthetic process', 'male gonad development', 'mesodermal cell differentiation', 'multicellular organism aging', 'negative regulation of B cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of follicle-stimulating hormone secretion', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of interferon-gamma production', 'negative regulation of macrophage differentiation', 'negative regulation of phosphorylation', 'nervous system development', 'odontogenesis', 'ovarian follicle development', 'positive regulation of erythrocyte differentiation', 'positive regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'positive regulation of follicle-stimulating hormone secretion', 'positive regulation of gene expression', 'positive regulation of ovulation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein metabolic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'progesterone secretion', 'regulation of follicle-stimulating hormone secretion', 'regulation of transcription by RNA polymerase II', 'response to xenobiotic stimulus', 'roof of mouth development', 'SMAD protein signal transduction', 'striatal medium spiny neuron differentiation', 'transcription by RNA polymerase II']['activin receptor signaling pathway', 'cell differentiation', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular response to cholesterol', 'cellular response to follicle-stimulating hormone stimulus', 'defense response', 'endodermal cell differentiation', 'erythrocyte differentiation', 'extrinsic apoptotic signaling pathway', 'eyelid development in camera-type eye', 'GABAergic neuron differentiation', 'hair follicle development', 'hematopoietic progenitor cell differentiation', 'hemoglobin biosynthetic process', 'male gonad development', 'mesodermal cell differentiation', 'multicellular organism aging', 'negative regulation of B cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of follicle-stimulating hormone secretion', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of interferon-gamma production', 'negative regulation of macrophage differentiation', 'negative regulation of phosphorylation', 'nervous system development', 'odontogenesis', 'ovarian follicle development', 'positive regulation of erythrocyte differentiation', 'positive regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'positive regulation of follicle-stimulating hormone secretion', 'positive regulation of gene expression', 'positive regulation of ovulation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein metabolic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'progesterone secretion', 'regulation of follicle-stimulating hormone secretion', 'regulation of transcription by RNA polymerase II', 'response to xenobiotic stimulus', 'roof of mouth development', 'SMAD protein signal transduction', 'striatal medium spiny neuron differentiation', 'transcription by RNA polymerase II']
Suppressor of tumorigenicity 14 protein
657
Kunitz-type protease inhibitor 1
283
8.2
90
0.14
Q9Y5Y6O43278['epithelial cell morphogenesis involved in placental branching', 'keratinocyte differentiation', 'neural tube closure', 'protein catabolic process', 'proteolysis']['branching involved in labyrinthine layer morphogenesis', 'cellular response to BMP stimulus', 'epidermis development', 'epithelium development', 'extracellular matrix organization', 'negative regulation of neural precursor cell proliferation', 'neural tube closure', 'placenta blood vessel development', 'positive regulation of glial cell differentiation']
Trifunctional purine biosynthetic protein adenosine-3
62
Trifunctional purine biosynthetic protein adenosine-3
322
9.8
78
0.13
P22102P22102["'de novo' AMP biosynthetic process", "'de novo' IMP biosynthetic process", "'de novo' XMP biosynthetic process", 'adenine biosynthetic process', 'brainstem development', 'cerebellum development', 'cerebral cortex development', 'glycine metabolic process', 'GMP biosynthetic process', 'purine nucleotide biosynthetic process', 'purine ribonucleoside monophosphate biosynthetic process', 'response to inorganic substance', 'response to organic substance', 'tetrahydrofolate biosynthetic process']["'de novo' AMP biosynthetic process", "'de novo' IMP biosynthetic process", "'de novo' XMP biosynthetic process", 'adenine biosynthetic process', 'brainstem development', 'cerebellum development', 'cerebral cortex development', 'glycine metabolic process', 'GMP biosynthetic process', 'purine nucleotide biosynthetic process', 'purine ribonucleoside monophosphate biosynthetic process', 'response to inorganic substance', 'response to organic substance', 'tetrahydrofolate biosynthetic process']
Lectin-related NK cell receptor LY49L4
153
Lectin-related NK cell receptor LY49L4
153
8.7
64
0.18
Q9JIP9Q9JIP9[][]
NF-kappa-B essential modulator
76
Inhibitor of nuclear factor kappa-B kinase subunit beta
716
8.7
66
0.17
Q9Y6K9O14920['anoikis', 'apoptotic process', 'cellular response to DNA damage stimulus', 'establishment of vesicle localization', 'I-kappaB kinase/NF-kappaB signaling', 'immune response', 'inflammatory response', 'innate immune response', 'negative regulation of neuron death', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of macroautophagy', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of T cell receptor signaling pathway', 'positive regulation of transcription by RNA polymerase II', 'protein-containing complex assembly', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'response to virus', 'T cell receptor signaling pathway']['antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent', 'cellular response to tumor necrosis factor', 'cortical actin cytoskeleton organization', 'Fc-epsilon receptor signaling pathway', 'I-kappaB kinase/NF-kappaB signaling', 'inflammatory response', 'innate immune response', 'interleukin-1-mediated signaling pathway', 'negative regulation of bicellular tight junction assembly', 'negative regulation of myosin-light-chain-phosphatase activity', 'peptidyl-serine phosphorylation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein localization to plasma membrane', 'protein phosphorylation', 'regulation of establishment of endothelial barrier', 'regulation of phosphorylation', 'regulation of tumor necrosis factor-mediated signaling pathway', 'response to virus', 'stimulatory C-type lectin receptor signaling pathway', 'stress-activated MAPK cascade', 'T cell receptor signaling pathway', 'tumor necrosis factor-mediated signaling pathway']
Ankyrin repeat and SOCS box protein 9
262
Elongin-C
112
8.7
nan
nan
Q96DX5Q15369['intracellular signal transduction', 'positive regulation of protein catabolic process', 'protein ubiquitination']['protein ubiquitination', 'regulation of transcription by RNA polymerase II', 'transcription initiation from RNA polymerase II promoter', 'ubiquitin-dependent protein catabolic process']
Pleckstrin
295
Pleckstrin
250
9.9
78
0.13
P08567P08567['actin cytoskeleton reorganization', 'cell projection organization', 'cortical actin cytoskeleton organization', 'hematopoietic progenitor cell differentiation', 'integrin-mediated signaling pathway', 'negative regulation of calcium-mediated signaling', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of inositol phosphate biosynthetic process', 'phosphatidylinositol metabolic process', 'phospholipase C-inhibiting G protein-coupled receptor signaling pathway', 'platelet aggregation', 'platelet degranulation', 'positive regulation of actin filament bundle assembly', 'positive regulation of actin filament depolymerization', 'positive regulation of inositol-polyphosphate 5-phosphatase activity', 'positive regulation of integrin activation', 'positive regulation of platelet activation', 'protein kinase C signaling', 'protein secretion by platelet', 'regulation of cell diameter', 'ruffle organization', 'thrombin-activated receptor signaling pathway', 'vesicle docking involved in exocytosis']['actin cytoskeleton reorganization', 'cell projection organization', 'cortical actin cytoskeleton organization', 'hematopoietic progenitor cell differentiation', 'integrin-mediated signaling pathway', 'negative regulation of calcium-mediated signaling', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of inositol phosphate biosynthetic process', 'phosphatidylinositol metabolic process', 'phospholipase C-inhibiting G protein-coupled receptor signaling pathway', 'platelet aggregation', 'platelet degranulation', 'positive regulation of actin filament bundle assembly', 'positive regulation of actin filament depolymerization', 'positive regulation of inositol-polyphosphate 5-phosphatase activity', 'positive regulation of integrin activation', 'positive regulation of platelet activation', 'protein kinase C signaling', 'protein secretion by platelet', 'regulation of cell diameter', 'ruffle organization', 'thrombin-activated receptor signaling pathway', 'vesicle docking involved in exocytosis']
Transcription factor IIIB 50 kDa subunit
370
TATA-box-binding protein
262
9.9
54
0.19
Q9HAW0P20226['cellular response to oxidative stress', 'DNA-templated transcription, initiation', 'regulation of transcription by RNA polymerase III', 'transcription preinitiation complex assembly']['DNA-templated transcription, initiation', 'mRNA transcription by RNA polymerase II', 'positive regulation of transcription initiation from RNA polymerase II promoter', 'protein phosphorylation', 'RNA polymerase II preinitiation complex assembly', 'transcription by RNA polymerase II', 'transcription by RNA polymerase III', 'transcription initiation from RNA polymerase II promoter']
Centrosomal protein of 152 kDa
1279
Centrosomal protein of 152 kDa
1279
9.9
40
0.25
O94986O94986['cell projection organization', 'centriole replication', 'centrosome duplication', 'de novo centriole assembly involved in multi-ciliated epithelial cell differentiation']['cell projection organization', 'centriole replication', 'centrosome duplication', 'de novo centriole assembly involved in multi-ciliated epithelial cell differentiation']
Glycine N-methyltransferase
58
Glycine N-methyltransferase
186
8.5
77
0.15
Q9QXF8Q9QXF8['glycine metabolic process', 'glycogen metabolic process', 'methionine metabolic process', 'methylation', 'one-carbon metabolic process', 'protein homotetramerization', 'regulation of gluconeogenesis', 'S-adenosylhomocysteine metabolic process', 'S-adenosylmethionine metabolic process', 'sarcosine metabolic process']['glycine metabolic process', 'glycogen metabolic process', 'methionine metabolic process', 'methylation', 'one-carbon metabolic process', 'protein homotetramerization', 'regulation of gluconeogenesis', 'S-adenosylhomocysteine metabolic process', 'S-adenosylmethionine metabolic process', 'sarcosine metabolic process']
Peptidyl-prolyl cis-trans isomerase FKBP2
97
Peptidyl-prolyl cis-trans isomerase FKBP2
97
8.5
68
0.17
P26885P26885['chaperone-mediated protein folding', 'protein peptidyl-prolyl isomerization']['chaperone-mediated protein folding', 'protein peptidyl-prolyl isomerization']
DNA (cytosine-5)-methyltransferase 3A
537
DNA (cytosine-5)-methyltransferase 3A
497
9.9
89
0.11
Q9Y6K1Q9Y6K1['aging', 'C-5 methylation of cytosine', 'cellular response to amino acid stimulus', 'cellular response to bisphenol A', 'cellular response to ethanol', 'cellular response to hypoxia', 'DNA methylation', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'DNA methylation on cytosine', 'DNA methylation-dependent heterochromatin assembly', 'hepatocyte apoptotic process', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron differentiation', 'positive regulation of cell death', 'regulation of gene expression by genomic imprinting', 'response to cocaine', 'response to estradiol', 'response to ionizing radiation', 'response to lead ion', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'spermatogenesis']['aging', 'C-5 methylation of cytosine', 'cellular response to amino acid stimulus', 'cellular response to bisphenol A', 'cellular response to ethanol', 'cellular response to hypoxia', 'DNA methylation', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'DNA methylation on cytosine', 'DNA methylation-dependent heterochromatin assembly', 'hepatocyte apoptotic process', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron differentiation', 'positive regulation of cell death', 'regulation of gene expression by genomic imprinting', 'response to cocaine', 'response to estradiol', 'response to ionizing radiation', 'response to lead ion', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'spermatogenesis']
Ubiquitin carboxyl-terminal hydrolase 34
1903
Ubiquitin carboxyl-terminal hydrolase 34
1903
8.5
93
0.13
Q70CQ2Q70CQ2['positive regulation of canonical Wnt signaling pathway', 'protein deubiquitination', 'protein K48-linked deubiquitination', 'ubiquitin-dependent protein catabolic process', 'Wnt signaling pathway']['positive regulation of canonical Wnt signaling pathway', 'protein deubiquitination', 'protein K48-linked deubiquitination', 'ubiquitin-dependent protein catabolic process', 'Wnt signaling pathway']
Bone morphogenetic protein 10
388
Bone morphogenetic protein 10
423
9.9
87
0.12
O95393O95393['activin receptor signaling pathway', 'adult heart development', 'atrial cardiac muscle tissue morphogenesis', 'BMP signaling pathway', 'cardiac muscle cell proliferation', 'cell adhesion', 'heart trabecula formation', 'kidney development', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of endothelial cell migration', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cartilage development', 'positive regulation of cell proliferation involved in heart morphogenesis', 'positive regulation of gene expression', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of sarcomere organization', 'positive regulation of transcription, DNA-templated', 'regulation of cardiac muscle contraction', 'regulation of cardiac muscle hypertrophy in response to stress', 'sarcomere organization', 'SMAD protein signal transduction', 'ventricular cardiac muscle cell development', 'ventricular cardiac muscle tissue morphogenesis']['activin receptor signaling pathway', 'adult heart development', 'atrial cardiac muscle tissue morphogenesis', 'BMP signaling pathway', 'cardiac muscle cell proliferation', 'cell adhesion', 'heart trabecula formation', 'kidney development', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of endothelial cell migration', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cartilage development', 'positive regulation of cell proliferation involved in heart morphogenesis', 'positive regulation of gene expression', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of sarcomere organization', 'positive regulation of transcription, DNA-templated', 'regulation of cardiac muscle contraction', 'regulation of cardiac muscle hypertrophy in response to stress', 'sarcomere organization', 'SMAD protein signal transduction', 'ventricular cardiac muscle cell development', 'ventricular cardiac muscle tissue morphogenesis']
Defensin-6
88
Defensin-6
88
9.9
62
0.16
Q01524Q01524['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'killing of cells of another organism', 'membrane disruption in another organism']
Serine/threonine-protein kinase MARK1
217
Serine/threonine-protein kinase MARK1
217
8.4
69
0.17
Q9P0L2Q9P0L2['cytoskeleton organization', 'establishment of mitochondrion localization', 'intracellular signal transduction', 'microtubule cytoskeleton organization', 'negative regulation of epithelial to mesenchymal transition', 'negative regulation of gene expression', 'neuron migration', 'peptidyl-serine phosphorylation', 'positive regulation of gene expression', 'protein phosphorylation', 'regulation of dendrite development', 'regulation of neuron projection development', 'Wnt signaling pathway']['cytoskeleton organization', 'establishment of mitochondrion localization', 'intracellular signal transduction', 'microtubule cytoskeleton organization', 'negative regulation of epithelial to mesenchymal transition', 'negative regulation of gene expression', 'neuron migration', 'peptidyl-serine phosphorylation', 'positive regulation of gene expression', 'protein phosphorylation', 'regulation of dendrite development', 'regulation of neuron projection development', 'Wnt signaling pathway']
3-hydroxy-3-methylglutaryl-coenzyme A reductase
526
3-hydroxy-3-methylglutaryl-coenzyme A reductase
561
9.9
66
0.15
P04035P04035['cholesterol biosynthetic process', 'coenzyme A metabolic process', 'isoprenoid biosynthetic process', 'negative regulation of amyloid-beta clearance', 'negative regulation of MAP kinase activity', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'sterol biosynthetic process', 'visual learning']['cholesterol biosynthetic process', 'coenzyme A metabolic process', 'isoprenoid biosynthetic process', 'negative regulation of amyloid-beta clearance', 'negative regulation of MAP kinase activity', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'sterol biosynthetic process', 'visual learning']
Kunitz-type protease inhibitor 2
47
Trypsin-3
121
8.4
93
0.13
O43291P35030['basement membrane organization', 'cellular response to BMP stimulus', 'epithelial cell morphogenesis involved in placental branching', 'establishment or maintenance of cell polarity', 'negative regulation of cell motility', 'negative regulation of cell-cell adhesion', 'negative regulation of neural precursor cell proliferation', 'neural tube closure']['antimicrobial humoral response', 'digestion', 'endothelial cell migration', 'proteolysis', 'zymogen activation']
Glucocorticoid receptor
473
Glucocorticoid receptor
457
9.9
71
0.14
P79269P79269['cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'chromatin organization', 'positive regulation of transcription by RNA polymerase II']['cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'chromatin organization', 'positive regulation of transcription by RNA polymerase II']
Transcriptional repressor CTCF
356
Transcriptional repressor CTCF
353
8.5
62
0.19
P49711P49711['chromatin looping', 'chromosome segregation', 'DNA methylation', 'genomic imprinting', 'maintenance of DNA methylation', 'negative regulation of cell population proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of gene expression', 'positive regulation of transcription, DNA-templated', 'protein localization to chromosome, centromeric region', 'regulation of centromeric sister chromatid cohesion', 'regulation of gene expression by genomic imprinting', 'regulation of gene expression, epigenetic', 'regulation of histone acetylation', 'regulation of histone methylation', 'regulation of transcription by RNA polymerase II']['chromatin looping', 'chromosome segregation', 'DNA methylation', 'genomic imprinting', 'maintenance of DNA methylation', 'negative regulation of cell population proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of gene expression', 'positive regulation of transcription, DNA-templated', 'protein localization to chromosome, centromeric region', 'regulation of centromeric sister chromatid cohesion', 'regulation of gene expression by genomic imprinting', 'regulation of gene expression, epigenetic', 'regulation of histone acetylation', 'regulation of histone methylation', 'regulation of transcription by RNA polymerase II']
Adrenodoxin, mitochondrial
104
Adrenodoxin, mitochondrial
110
8.4
82
0.15
P00257P00257['cellular response to cAMP', 'cellular response to forskolin', 'cholesterol metabolic process', 'electron transport chain', 'hormone biosynthetic process', 'P450-containing electron transport chain', 'positive regulation of oxidoreductase activity', 'respiratory electron transport chain', 'steroid biosynthetic process']['cellular response to cAMP', 'cellular response to forskolin', 'cholesterol metabolic process', 'electron transport chain', 'hormone biosynthetic process', 'P450-containing electron transport chain', 'positive regulation of oxidoreductase activity', 'respiratory electron transport chain', 'steroid biosynthetic process']
Caspase-8
313
Caspase-8
426
8.3
82
0.15
Q14790Q14790['activation of cysteine-type endopeptidase activity', 'activation of cysteine-type endopeptidase activity involved in apoptotic process', 'angiogenesis', 'apoptotic process', 'apoptotic signaling pathway', 'B cell activation', 'cellular response to mechanical stimulus', 'cellular response to organic cyclic compound', 'execution phase of apoptosis', 'extrinsic apoptotic signaling pathway', 'extrinsic apoptotic signaling pathway via death domain receptors', 'heart development', 'macrophage differentiation', 'natural killer cell activation', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of necroptotic process', 'positive regulation of apoptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interleukin-1 beta production', 'positive regulation of macrophage differentiation', 'positive regulation of neuron death', 'positive regulation of proteolysis', 'proteolysis', 'proteolysis involved in protein catabolic process', 'pyroptosis', 'regulation of cytokine production', 'regulation of innate immune response', 'regulation of tumor necrosis factor-mediated signaling pathway', 'response to antibiotic', 'response to cobalt ion', 'response to cold', 'response to estradiol', 'response to ethanol', 'response to lipopolysaccharide', 'response to tumor necrosis factor', 'self proteolysis', 'syncytiotrophoblast cell differentiation involved in labyrinthine layer development', 'T cell activation', 'TRAIL-activated apoptotic signaling pathway']['activation of cysteine-type endopeptidase activity', 'activation of cysteine-type endopeptidase activity involved in apoptotic process', 'angiogenesis', 'apoptotic process', 'apoptotic signaling pathway', 'B cell activation', 'cellular response to mechanical stimulus', 'cellular response to organic cyclic compound', 'execution phase of apoptosis', 'extrinsic apoptotic signaling pathway', 'extrinsic apoptotic signaling pathway via death domain receptors', 'heart development', 'macrophage differentiation', 'natural killer cell activation', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of necroptotic process', 'positive regulation of apoptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interleukin-1 beta production', 'positive regulation of macrophage differentiation', 'positive regulation of neuron death', 'positive regulation of proteolysis', 'proteolysis', 'proteolysis involved in protein catabolic process', 'pyroptosis', 'regulation of cytokine production', 'regulation of innate immune response', 'regulation of tumor necrosis factor-mediated signaling pathway', 'response to antibiotic', 'response to cobalt ion', 'response to cold', 'response to estradiol', 'response to ethanol', 'response to lipopolysaccharide', 'response to tumor necrosis factor', 'self proteolysis', 'syncytiotrophoblast cell differentiation involved in labyrinthine layer development', 'T cell activation', 'TRAIL-activated apoptotic signaling pathway']
Endothelin receptor type B
255
Endothelin-3
111
9.9
87
0.12
P24530P14138['aging', 'aldosterone metabolic process', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cell surface receptor signaling pathway', 'cellular response to lipopolysaccharide', 'cGMP-mediated signaling', 'developmental pigmentation', 'endothelin receptor signaling pathway', 'enteric nervous system development', 'enteric smooth muscle cell differentiation', 'epithelial fluid transport', 'establishment of endothelial barrier', 'gene expression', 'heparin metabolic process', 'I-kappaB kinase/NF-kappaB signaling', 'macrophage chemotaxis', 'melanocyte differentiation', 'negative regulation of adenylate cyclase activity', 'negative regulation of apoptotic process', 'negative regulation of neuron maturation', 'negative regulation of protein metabolic process', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'neural crest cell migration', 'neuroblast migration', 'peripheral nervous system development', 'pharynx development', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'podocyte differentiation', 'positive regulation of cell population proliferation', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of penile erection', 'positive regulation of protein phosphorylation', 'positive regulation of renal sodium excretion', 'positive regulation of urine volume', 'posterior midgut development', 'protein transmembrane transport', 'regulation of epithelial cell proliferation', 'regulation of fever generation', 'regulation of heart rate', 'regulation of pH', 'regulation of sensory perception of pain', 'renal albumin absorption', 'renal sodium excretion', 'renal sodium ion absorption', 'renin secretion into blood stream', 'response to endothelin', 'response to organic cyclic compound', 'response to pain', 'response to sodium phosphate', 'sensory perception of pain', 'vasoconstriction', 'vasodilation', 'vein smooth muscle contraction']['axon extension', 'axon guidance', 'blood circulation', 'cell population proliferation', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular magnesium ion homeostasis', 'establishment of localization in cell', 'inositol phosphate-mediated signaling', 'melanocyte differentiation', 'neural crest cell migration', 'neutrophil chemotaxis', 'peptide hormone secretion', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of leukocyte chemotaxis', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of potassium ion transmembrane transport', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'potassium ion transmembrane transport', 'regulation of developmental pigmentation', 'regulation of gene expression', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'signal transduction', 'vasoconstriction', 'vein smooth muscle contraction']
V(D)J recombination-activating protein 1
431
V(D)J recombination-activating protein 1
431
8.5
77
0.15
P15919P15919['adaptive immune response', 'B cell differentiation', 'chromatin organization', 'DNA recombination', 'histone monoubiquitination', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of T cell apoptotic process', 'negative regulation of thymocyte apoptotic process', 'positive regulation of T cell differentiation', 'pre-B cell allelic exclusion', 'protein autoubiquitination', 'regulation of behavioral fear response', 'regulation of T cell differentiation', 'T cell differentiation in thymus', 'T cell homeostasis', 'thymus development', 'V(D)J recombination', 'visual learning']['adaptive immune response', 'B cell differentiation', 'chromatin organization', 'DNA recombination', 'histone monoubiquitination', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of T cell apoptotic process', 'negative regulation of thymocyte apoptotic process', 'positive regulation of T cell differentiation', 'pre-B cell allelic exclusion', 'protein autoubiquitination', 'regulation of behavioral fear response', 'regulation of T cell differentiation', 'T cell differentiation in thymus', 'T cell homeostasis', 'thymus development', 'V(D)J recombination', 'visual learning']
Protein polybromo-1
736
Protein polybromo-1
736
8.5
69
0.17
Q86U86Q86U86['chromatin remodeling', 'mitotic cell cycle', 'negative regulation of cell population proliferation', 'positive regulation of cell differentiation', 'positive regulation of double-strand break repair', 'positive regulation of myoblast differentiation', 'positive regulation of T cell differentiation', 'regulation of G0 to G1 transition', 'regulation of G1/S transition of mitotic cell cycle', 'regulation of mitotic metaphase/anaphase transition', 'regulation of nucleotide-excision repair', 'regulation of transcription by RNA polymerase II']['chromatin remodeling', 'mitotic cell cycle', 'negative regulation of cell population proliferation', 'positive regulation of cell differentiation', 'positive regulation of double-strand break repair', 'positive regulation of myoblast differentiation', 'positive regulation of T cell differentiation', 'regulation of G0 to G1 transition', 'regulation of G1/S transition of mitotic cell cycle', 'regulation of mitotic metaphase/anaphase transition', 'regulation of nucleotide-excision repair', 'regulation of transcription by RNA polymerase II']
Ig gamma-2A chain C region, A allele
110
Ig gamma-2A chain C region, A allele
107
8.5
30
0.39
P01863P01863['B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'response to bacterium']['B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'response to bacterium']
Protein S100-B
85
Protein S100-B
85
8.2
59
0.21
P04271P04271['axonogenesis', 'central nervous system development', 'learning or memory', 'memory', 'positive regulation of cell population proliferation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of neuronal synaptic plasticity']['axonogenesis', 'central nervous system development', 'learning or memory', 'memory', 'positive regulation of cell population proliferation', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of neuronal synaptic plasticity']
Pancreatic secretory granule membrane major glycoprotein GP2
138
Pancreatic secretory granule membrane major glycoprotein GP2
172
8.8
73
0.16
P55259P55259['antigen transcytosis by M cells in mucosal-associated lymphoid tissue', 'innate immune response', 'neutrophil migration']['antigen transcytosis by M cells in mucosal-associated lymphoid tissue', 'innate immune response', 'neutrophil migration']
DNA (cytosine-5)-methyltransferase 3A
540
DNA (cytosine-5)-methyltransferase 3A
494
9.8
88
0.12
Q9Y6K1Q9Y6K1['aging', 'C-5 methylation of cytosine', 'cellular response to amino acid stimulus', 'cellular response to bisphenol A', 'cellular response to ethanol', 'cellular response to hypoxia', 'DNA methylation', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'DNA methylation on cytosine', 'DNA methylation-dependent heterochromatin assembly', 'hepatocyte apoptotic process', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron differentiation', 'positive regulation of cell death', 'regulation of gene expression by genomic imprinting', 'response to cocaine', 'response to estradiol', 'response to ionizing radiation', 'response to lead ion', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'spermatogenesis']['aging', 'C-5 methylation of cytosine', 'cellular response to amino acid stimulus', 'cellular response to bisphenol A', 'cellular response to ethanol', 'cellular response to hypoxia', 'DNA methylation', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'DNA methylation on cytosine', 'DNA methylation-dependent heterochromatin assembly', 'hepatocyte apoptotic process', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron differentiation', 'positive regulation of cell death', 'regulation of gene expression by genomic imprinting', 'response to cocaine', 'response to estradiol', 'response to ionizing radiation', 'response to lead ion', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'spermatogenesis']
Laminin subunit beta-1
1785
Laminin subunit beta-1
1785
10.0
64
0.16
P07942P07942['animal organ morphogenesis', 'basement membrane assembly', 'cell adhesion', 'cell migration', 'endodermal cell differentiation', 'neuron projection development', 'neuronal-glial interaction involved in cerebral cortex radial glia guided migration', 'odontogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of epithelial cell proliferation', 'positive regulation of integrin-mediated signaling pathway', 'positive regulation of muscle cell differentiation', 'regulation of basement membrane organization', 'substrate adhesion-dependent cell spreading', 'tissue development']['animal organ morphogenesis', 'basement membrane assembly', 'cell adhesion', 'cell migration', 'endodermal cell differentiation', 'neuron projection development', 'neuronal-glial interaction involved in cerebral cortex radial glia guided migration', 'odontogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of epithelial cell proliferation', 'positive regulation of integrin-mediated signaling pathway', 'positive regulation of muscle cell differentiation', 'regulation of basement membrane organization', 'substrate adhesion-dependent cell spreading', 'tissue development']
GMP synthase [glutamine-hydrolyzing]
523
GMP synthase [glutamine-hydrolyzing]
523
8.9
68
0.17
P49915P49915['glutamine metabolic process', 'GMP biosynthetic process', 'purine nucleobase biosynthetic process', 'purine ribonucleoside monophosphate biosynthetic process']['glutamine metabolic process', 'GMP biosynthetic process', 'purine nucleobase biosynthetic process', 'purine ribonucleoside monophosphate biosynthetic process']
DCN1-like protein 1
115
DCN1-like protein 1
115
8.2
53
0.23
Q96GG9Q96GG9['positive regulation of protein neddylation', 'positive regulation of ubiquitin-protein transferase activity', 'protein neddylation', 'regulation of protein neddylation', 'regulation of protein ubiquitination']['positive regulation of protein neddylation', 'positive regulation of ubiquitin-protein transferase activity', 'protein neddylation', 'regulation of protein neddylation', 'regulation of protein ubiquitination']
NKG2-D type II integral membrane protein
121
NKG2-D type II integral membrane protein
115
8.8
81
0.14
O54709O54709['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of apoptotic process', 'positive regulation of interferon-gamma production', 'positive regulation of myeloid dendritic cell activation', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target', 'positive regulation of nitric oxide biosynthetic process', 'stimulatory C-type lectin receptor signaling pathway']['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of apoptotic process', 'positive regulation of interferon-gamma production', 'positive regulation of myeloid dendritic cell activation', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target', 'positive regulation of nitric oxide biosynthetic process', 'stimulatory C-type lectin receptor signaling pathway']
General transcription factor IIH subunit 3
142
General transcription factor IIH subunit 2
368
8.1
75
0.16
Q13889Q13888['DNA repair', 'nucleotide-excision repair', 'phosphorylation of RNA polymerase II C-terminal domain', 'transcription by RNA polymerase II']['G protein-coupled receptor internalization', 'nucleotide-excision repair', 'positive regulation of DNA helicase activity', 'regulation of transcription by RNA polymerase II', 'response to UV', 'transcription by RNA polymerase II', 'transcription initiation from RNA polymerase II promoter']
Neurotrophin-3
248
Neurotrophin-3
152
8.8
83
0.14
P20783P20783['activation of GTPase activity', 'activation of protein kinase B activity', 'cell-cell signaling', 'induction of positive chemotaxis', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of peptidyl-tyrosine phosphorylation', 'nerve development', 'nerve growth factor signaling pathway', 'nervous system development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of MAP kinase activity', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of receptor internalization', 'regulation of apoptotic process', 'regulation of neuron differentiation', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of GTPase activity', 'activation of protein kinase B activity', 'cell-cell signaling', 'induction of positive chemotaxis', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of peptidyl-tyrosine phosphorylation', 'nerve development', 'nerve growth factor signaling pathway', 'nervous system development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of MAP kinase activity', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of receptor internalization', 'regulation of apoptotic process', 'regulation of neuron differentiation', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Histone deacetylase 6
1148
Histone deacetylase 6
1148
8.8
76
0.15
Q9UBN7Q9UBN7['aggresome assembly', 'autophagy', 'axonal transport of mitochondrion', 'cellular response to hydrogen peroxide', 'cellular response to misfolded protein', 'cellular response to topologically incorrect protein', 'cilium assembly', 'cilium disassembly', 'collateral sprouting', 'dendritic spine morphogenesis', 'histone deacetylation', 'Hsp90 deacetylation', 'intracellular protein transport', 'lysosome localization', 'negative regulation of hydrogen peroxide metabolic process', 'negative regulation of microtubule depolymerization', 'negative regulation of oxidoreductase activity', 'negative regulation of protein-containing complex assembly', 'negative regulation of protein-containing complex disassembly', 'negative regulation of proteolysis', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization', 'peptidyl-lysine deacetylation', 'polyubiquitinated misfolded protein transport', 'positive regulation of epithelial cell migration', 'positive regulation of hydrogen peroxide-mediated programmed cell death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of signaling receptor activity', 'protein deacetylation', 'protein destabilization', 'protein polyubiquitination', 'protein quality control for misfolded or incompletely synthesized proteins', 'protein-containing complex disassembly', 'regulation of androgen receptor signaling pathway', 'regulation of autophagy', 'regulation of autophagy of mitochondrion', 'regulation of establishment of protein localization', 'regulation of fat cell differentiation', 'regulation of gene expression, epigenetic', 'regulation of macroautophagy', 'regulation of microtubule-based movement', 'regulation of protein stability', 'response to growth factor', 'response to misfolded protein', 'tubulin deacetylation', 'ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway']['aggresome assembly', 'autophagy', 'axonal transport of mitochondrion', 'cellular response to hydrogen peroxide', 'cellular response to misfolded protein', 'cellular response to topologically incorrect protein', 'cilium assembly', 'cilium disassembly', 'collateral sprouting', 'dendritic spine morphogenesis', 'histone deacetylation', 'Hsp90 deacetylation', 'intracellular protein transport', 'lysosome localization', 'negative regulation of hydrogen peroxide metabolic process', 'negative regulation of microtubule depolymerization', 'negative regulation of oxidoreductase activity', 'negative regulation of protein-containing complex assembly', 'negative regulation of protein-containing complex disassembly', 'negative regulation of proteolysis', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization', 'peptidyl-lysine deacetylation', 'polyubiquitinated misfolded protein transport', 'positive regulation of epithelial cell migration', 'positive regulation of hydrogen peroxide-mediated programmed cell death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of signaling receptor activity', 'protein deacetylation', 'protein destabilization', 'protein polyubiquitination', 'protein quality control for misfolded or incompletely synthesized proteins', 'protein-containing complex disassembly', 'regulation of androgen receptor signaling pathway', 'regulation of autophagy', 'regulation of autophagy of mitochondrion', 'regulation of establishment of protein localization', 'regulation of fat cell differentiation', 'regulation of gene expression, epigenetic', 'regulation of macroautophagy', 'regulation of microtubule-based movement', 'regulation of protein stability', 'response to growth factor', 'response to misfolded protein', 'tubulin deacetylation', 'ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway']
Microtubule-associated proteins 1A/1B light chain 3A
17
Microtubule-associated proteins 1A/1B light chain 3A
17
8.8
66
0.17
Q9H492Q9H492['autophagosome assembly', 'autophagosome maturation', 'autophagy of mitochondrion', 'cellular response to amino acid starvation', 'cellular response to copper ion', 'cellular response to hydrogen peroxide', 'cellular response to nitrogen starvation', 'cellular response to starvation', 'macroautophagy', 'response to iron(II) ion', 'response to lead ion', 'response to morphine']['autophagosome assembly', 'autophagosome maturation', 'autophagy of mitochondrion', 'cellular response to amino acid starvation', 'cellular response to copper ion', 'cellular response to hydrogen peroxide', 'cellular response to nitrogen starvation', 'cellular response to starvation', 'macroautophagy', 'response to iron(II) ion', 'response to lead ion', 'response to morphine']
Dopamine beta-hydroxylase
530
Dopamine beta-hydroxylase
530
8.2
37
0.33
P09172P09172['behavioral response to ethanol', 'blood vessel remodeling', 'chemical synaptic transmission', 'dopamine catabolic process', 'fear response', 'glucose homeostasis', 'homoiothermy', 'leukocyte mediated immunity', 'leukocyte migration', 'locomotory behavior', 'maternal behavior', 'memory', 'norepinephrine biosynthetic process', 'octopamine biosynthetic process', 'positive regulation of cold-induced thermogenesis', 'positive regulation of vasoconstriction', 'regulation of extrinsic apoptotic signaling pathway', 'regulation of vascular associated smooth muscle cell proliferation', 'regulation of vascular endothelial cell proliferation', 'response to amphetamine', 'response to pain', 'vasoconstriction', 'visual learning']['behavioral response to ethanol', 'blood vessel remodeling', 'chemical synaptic transmission', 'dopamine catabolic process', 'fear response', 'glucose homeostasis', 'homoiothermy', 'leukocyte mediated immunity', 'leukocyte migration', 'locomotory behavior', 'maternal behavior', 'memory', 'norepinephrine biosynthetic process', 'octopamine biosynthetic process', 'positive regulation of cold-induced thermogenesis', 'positive regulation of vasoconstriction', 'regulation of extrinsic apoptotic signaling pathway', 'regulation of vascular associated smooth muscle cell proliferation', 'regulation of vascular endothelial cell proliferation', 'response to amphetamine', 'response to pain', 'vasoconstriction', 'visual learning']
Cytoplasmic FMR1-interacting protein 1
731
Nck-associated protein 1
633
8.8
66
0.17
Q7L576Q9Y2A7['axon extension', 'axon guidance', 'cell morphogenesis', 'cell projection assembly', 'cellular response to insulin stimulus', 'cognition', 'dendrite extension', 'lamellipodium assembly', 'modification of synaptic structure', 'negative regulation of synaptic vesicle recycling', 'positive regulation of Arp2/3 complex-mediated actin nucleation', 'positive regulation of axon extension', 'positive regulation of dendrite development', 'positive regulation of lamellipodium assembly', 'positive regulation of neurotrophin TRK receptor signaling pathway', 'positive regulation of ruffle assembly', 'Rac protein signal transduction', 'regulation of actin filament polymerization', 'regulation of cell shape', 'regulation of modification of postsynaptic actin cytoskeleton', 'regulation of myelination', 'regulation of translation', 'regulation of translation at postsynapse, modulating synaptic transmission', 'response to electrical stimulus', 'ruffle organization']['apoptotic process', 'cell migration', 'cell morphogenesis', 'cell projection assembly', 'central nervous system development', 'cortical actin cytoskeleton organization', 'neuron projection morphogenesis', 'positive regulation of actin filament polymerization', 'positive regulation of Arp2/3 complex-mediated actin nucleation', 'positive regulation of lamellipodium assembly', 'Rac protein signal transduction']
Gamma-interferon-inducible lysosomal thiol reductase
159
Gamma-interferon-inducible lysosomal thiol reductase
145
8.8
78
0.15
Q9ESY9Q9ESY9['antigen processing and presentation of exogenous peptide antigen via MHC class I', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'negative regulation of fibroblast proliferation', 'protein stabilization']['antigen processing and presentation of exogenous peptide antigen via MHC class I', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'negative regulation of fibroblast proliferation', 'protein stabilization']
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
263
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
254
10.0
90
0.11
P50213O43837['carbohydrate metabolic process', 'isocitrate metabolic process', 'tricarboxylic acid cycle']['2-oxoglutarate metabolic process', 'isocitrate metabolic process', 'NADH metabolic process', 'tricarboxylic acid cycle']
PHD finger protein 6
283
PHD finger protein 6
283
10.0
68
0.15
Q8IWS0Q8IWS0['blastocyst hatching', 'negative regulation of transcription by RNA polymerase II', 'regulation of transcription by RNA polymerase II']['blastocyst hatching', 'negative regulation of transcription by RNA polymerase II', 'regulation of transcription by RNA polymerase II']
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
938
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
938
8.2
56
0.22
P04191P04191['calcium ion import into sarcoplasmic reticulum', 'calcium ion transport', 'negative regulation of striated muscle contraction', 'positive regulation of ATPase-coupled calcium transmembrane transporter activity', 'positive regulation of calcium ion import into sarcoplasmic reticulum', 'positive regulation of cardiac muscle cell contraction', 'positive regulation of fast-twitch skeletal muscle fiber contraction', 'regulation of striated muscle contraction']['calcium ion import into sarcoplasmic reticulum', 'calcium ion transport', 'negative regulation of striated muscle contraction', 'positive regulation of ATPase-coupled calcium transmembrane transporter activity', 'positive regulation of calcium ion import into sarcoplasmic reticulum', 'positive regulation of cardiac muscle cell contraction', 'positive regulation of fast-twitch skeletal muscle fiber contraction', 'regulation of striated muscle contraction']
Peroxiredoxin-5, mitochondrial
100
Peroxiredoxin-5, mitochondrial
204
8.5
66
0.18
P30044P30044['cell redox homeostasis', 'cellular response to oxidative stress', 'cellular response to reactive oxygen species', 'hydrogen peroxide catabolic process', 'inflammatory response', 'NADPH oxidation', 'negative regulation of apoptotic process', 'negative regulation of oxidoreductase activity', 'negative regulation of transcription by RNA polymerase III', 'positive regulation of collagen biosynthetic process', 'reactive nitrogen species metabolic process', 'regulation of apoptosis involved in tissue homeostasis', 'response to oxidative stress']['cell redox homeostasis', 'cellular response to oxidative stress', 'cellular response to reactive oxygen species', 'hydrogen peroxide catabolic process', 'inflammatory response', 'NADPH oxidation', 'negative regulation of apoptotic process', 'negative regulation of oxidoreductase activity', 'negative regulation of transcription by RNA polymerase III', 'positive regulation of collagen biosynthetic process', 'reactive nitrogen species metabolic process', 'regulation of apoptosis involved in tissue homeostasis', 'response to oxidative stress']
Prosaposin
201
Prosaposin
201
9.9
76
0.13
P07602P07602['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'epithelial cell differentiation involved in prostate gland development', 'ganglioside GM1 transport to membrane', 'lysosomal transport', 'positive regulation of beta-galactosidase activity', 'prostate gland growth', 'regulation of autophagy', 'regulation of lipid metabolic process', 'sphingolipid metabolic process']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'epithelial cell differentiation involved in prostate gland development', 'ganglioside GM1 transport to membrane', 'lysosomal transport', 'positive regulation of beta-galactosidase activity', 'prostate gland growth', 'regulation of autophagy', 'regulation of lipid metabolic process', 'sphingolipid metabolic process']
Neurogenic locus notch homolog protein 1
1549
Neurogenic locus notch homolog protein 1
1549
8.8
83
0.14
P46531P46531['animal organ regeneration', 'aortic valve morphogenesis', 'apoptotic process involved in embryonic digit morphogenesis', 'arterial endothelial cell differentiation', 'astrocyte differentiation', 'atrioventricular node development', 'atrioventricular valve morphogenesis', 'auditory receptor cell fate commitment', 'axon guidance', 'branching morphogenesis of an epithelial tube', 'calcium-ion regulated exocytosis', 'cardiac atrium morphogenesis', 'cardiac chamber formation', 'cardiac epithelial to mesenchymal transition', 'cardiac left ventricle morphogenesis', 'cardiac muscle cell myoblast differentiation', 'cardiac muscle cell proliferation', 'cardiac muscle tissue morphogenesis', 'cardiac right atrium morphogenesis', 'cardiac right ventricle formation', 'cardiac septum morphogenesis', 'cardiac vascular smooth muscle cell development', 'cardiac ventricle morphogenesis', 'cell differentiation in spinal cord', 'cell migration involved in endocardial cushion formation', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to tumor cell', 'cellular response to vascular endothelial growth factor stimulus', 'cilium assembly', 'collecting duct development', 'compartment pattern specification', 'coronary artery morphogenesis', 'coronary sinus valve morphogenesis', 'coronary vein morphogenesis', 'determination of left/right symmetry', 'distal tubule development', 'embryonic hindlimb morphogenesis', 'endocardial cell differentiation', 'endocardial cushion morphogenesis', 'endocardium development', 'endocardium morphogenesis', 'endoderm development', 'epidermal cell fate specification', 'epithelial cell fate commitment', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'epithelial to mesenchymal transition involved in endocardial cushion formation', 'forebrain development', 'foregut morphogenesis', 'glomerular mesangial cell development', 'growth involved in heart morphogenesis', 'hair follicle morphogenesis', 'heart development', 'heart looping', 'heart trabecula morphogenesis', 'homeostasis of number of cells within a tissue', 'humoral immune response', 'immune response', 'in utero embryonic development', 'inflammatory response to antigenic stimulus', 'inhibition of neuroepithelial cell differentiation', 'interleukin-17-mediated signaling pathway', 'keratinocyte differentiation', 'left/right axis specification', 'liver development', 'lung development', 'mesenchymal cell development', 'mitral valve formation', 'negative regulation of anoikis', 'negative regulation of biomineral tissue development', 'negative regulation of BMP signaling pathway', 'negative regulation of calcium ion-dependent exocytosis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of catalytic activity', 'negative regulation of cell adhesion molecule production', 'negative regulation of cell migration involved in sprouting angiogenesis', 'negative regulation of cell population proliferation', 'negative regulation of cell proliferation involved in heart valve morphogenesis', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cell-substrate adhesion', 'negative regulation of cold-induced thermogenesis', 'negative regulation of endothelial cell chemotaxis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix constituent secretion', 'negative regulation of gene expression', 'negative regulation of glial cell proliferation', 'negative regulation of inner ear auditory receptor cell differentiation', 'negative regulation of myoblast differentiation', 'negative regulation of myotube differentiation', 'negative regulation of neurogenesis', 'negative regulation of oligodendrocyte differentiation', 'negative regulation of ossification', 'negative regulation of osteoblast differentiation', 'negative regulation of photoreceptor cell differentiation', 'negative regulation of pro-B cell differentiation', 'negative regulation of stem cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube development', 'neuroendocrine cell differentiation', 'neuronal stem cell population maintenance', 'Notch signaling involved in heart development', 'Notch signaling pathway', 'Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation', 'oligodendrocyte differentiation', 'outflow tract morphogenesis', 'pericardium morphogenesis', 'positive regulation of aorta morphogenesis', 'positive regulation of apoptotic process involved in morphogenesis', 'positive regulation of astrocyte differentiation', 'positive regulation of BMP signaling pathway', 'positive regulation of cardiac epithelial to mesenchymal transition', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell differentiation', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of keratinocyte differentiation', 'positive regulation of neuroblast proliferation', 'positive regulation of Notch signaling pathway', 'positive regulation of Ras protein signal transduction', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription of Notch receptor target', 'positive regulation of transcription, DNA-templated', 'positive regulation of viral genome replication', 'prostate gland epithelium morphogenesis', 'protein catabolic process', 'protein import into nucleus', 'pulmonary valve morphogenesis', 'regulation of epithelial cell proliferation involved in prostate gland development', 'regulation of extracellular matrix assembly', 'regulation of somitogenesis', 'regulation of stem cell proliferation', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to corticosteroid', 'response to lipopolysaccharide', 'response to muramyl dipeptide', 'retinal cone cell differentiation', 'secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development', 'skeletal muscle cell differentiation', 'somatic stem cell division', 'spermatogenesis', 'sprouting angiogenesis', 'T-helper 17 type immune response', 'tissue regeneration', 'transcription by RNA polymerase II', 'tube formation', 'vasculogenesis involved in coronary vascular morphogenesis', 'venous endothelial cell differentiation', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis']['animal organ regeneration', 'aortic valve morphogenesis', 'apoptotic process involved in embryonic digit morphogenesis', 'arterial endothelial cell differentiation', 'astrocyte differentiation', 'atrioventricular node development', 'atrioventricular valve morphogenesis', 'auditory receptor cell fate commitment', 'axon guidance', 'branching morphogenesis of an epithelial tube', 'calcium-ion regulated exocytosis', 'cardiac atrium morphogenesis', 'cardiac chamber formation', 'cardiac epithelial to mesenchymal transition', 'cardiac left ventricle morphogenesis', 'cardiac muscle cell myoblast differentiation', 'cardiac muscle cell proliferation', 'cardiac muscle tissue morphogenesis', 'cardiac right atrium morphogenesis', 'cardiac right ventricle formation', 'cardiac septum morphogenesis', 'cardiac vascular smooth muscle cell development', 'cardiac ventricle morphogenesis', 'cell differentiation in spinal cord', 'cell migration involved in endocardial cushion formation', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to tumor cell', 'cellular response to vascular endothelial growth factor stimulus', 'cilium assembly', 'collecting duct development', 'compartment pattern specification', 'coronary artery morphogenesis', 'coronary sinus valve morphogenesis', 'coronary vein morphogenesis', 'determination of left/right symmetry', 'distal tubule development', 'embryonic hindlimb morphogenesis', 'endocardial cell differentiation', 'endocardial cushion morphogenesis', 'endocardium development', 'endocardium morphogenesis', 'endoderm development', 'epidermal cell fate specification', 'epithelial cell fate commitment', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'epithelial to mesenchymal transition involved in endocardial cushion formation', 'forebrain development', 'foregut morphogenesis', 'glomerular mesangial cell development', 'growth involved in heart morphogenesis', 'hair follicle morphogenesis', 'heart development', 'heart looping', 'heart trabecula morphogenesis', 'homeostasis of number of cells within a tissue', 'humoral immune response', 'immune response', 'in utero embryonic development', 'inflammatory response to antigenic stimulus', 'inhibition of neuroepithelial cell differentiation', 'interleukin-17-mediated signaling pathway', 'keratinocyte differentiation', 'left/right axis specification', 'liver development', 'lung development', 'mesenchymal cell development', 'mitral valve formation', 'negative regulation of anoikis', 'negative regulation of biomineral tissue development', 'negative regulation of BMP signaling pathway', 'negative regulation of calcium ion-dependent exocytosis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of catalytic activity', 'negative regulation of cell adhesion molecule production', 'negative regulation of cell migration involved in sprouting angiogenesis', 'negative regulation of cell population proliferation', 'negative regulation of cell proliferation involved in heart valve morphogenesis', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cell-substrate adhesion', 'negative regulation of cold-induced thermogenesis', 'negative regulation of endothelial cell chemotaxis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix constituent secretion', 'negative regulation of gene expression', 'negative regulation of glial cell proliferation', 'negative regulation of inner ear auditory receptor cell differentiation', 'negative regulation of myoblast differentiation', 'negative regulation of myotube differentiation', 'negative regulation of neurogenesis', 'negative regulation of oligodendrocyte differentiation', 'negative regulation of ossification', 'negative regulation of osteoblast differentiation', 'negative regulation of photoreceptor cell differentiation', 'negative regulation of pro-B cell differentiation', 'negative regulation of stem cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube development', 'neuroendocrine cell differentiation', 'neuronal stem cell population maintenance', 'Notch signaling involved in heart development', 'Notch signaling pathway', 'Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation', 'oligodendrocyte differentiation', 'outflow tract morphogenesis', 'pericardium morphogenesis', 'positive regulation of aorta morphogenesis', 'positive regulation of apoptotic process involved in morphogenesis', 'positive regulation of astrocyte differentiation', 'positive regulation of BMP signaling pathway', 'positive regulation of cardiac epithelial to mesenchymal transition', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell differentiation', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of keratinocyte differentiation', 'positive regulation of neuroblast proliferation', 'positive regulation of Notch signaling pathway', 'positive regulation of Ras protein signal transduction', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription of Notch receptor target', 'positive regulation of transcription, DNA-templated', 'positive regulation of viral genome replication', 'prostate gland epithelium morphogenesis', 'protein catabolic process', 'protein import into nucleus', 'pulmonary valve morphogenesis', 'regulation of epithelial cell proliferation involved in prostate gland development', 'regulation of extracellular matrix assembly', 'regulation of somitogenesis', 'regulation of stem cell proliferation', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to corticosteroid', 'response to lipopolysaccharide', 'response to muramyl dipeptide', 'retinal cone cell differentiation', 'secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development', 'skeletal muscle cell differentiation', 'somatic stem cell division', 'spermatogenesis', 'sprouting angiogenesis', 'T-helper 17 type immune response', 'tissue regeneration', 'transcription by RNA polymerase II', 'tube formation', 'vasculogenesis involved in coronary vascular morphogenesis', 'venous endothelial cell differentiation', 'ventricular septum morphogenesis', 'ventricular trabecula myocardium morphogenesis']
Chymotrypsin-like elastase family member 1
56
Elafin
83
8.2
96
0.13
P00772P19957['proteolysis']['antibacterial humoral response', 'copulation', 'innate immune response', 'peptide cross-linking']
Glial cell line-derived neurotrophic factor
178
Glial cell line-derived neurotrophic factor
178
2.0
71
0.71
Q07731Q07731['branching involved in ureteric bud morphogenesis', 'cell population proliferation', 'cellular response to dexamethasone stimulus', 'commissural neuron axon guidance', 'dorsal spinal cord development', 'embryonic organ development', 'enteric nervous system development', 'male gonad development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'metanephros development', 'midbrain development', 'mRNA stabilization', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of neuron apoptotic process', 'nervous system development', 'neural crest cell migration', 'neuron differentiation', 'neuron projection development', 'organ induction', 'peripheral nervous system development', 'peristalsis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis', 'positive regulation of monooxygenase activity', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of ureteric bud formation', 'postganglionic parasympathetic fiber development', 'postsynaptic membrane organization', 'regulation of dopamine uptake involved in synaptic transmission', 'regulation of gene expression', 'regulation of morphogenesis of a branching structure', 'regulation of semaphorin-plexin signaling pathway', 'regulation of ureteric bud formation', 'response to wounding', 'retina development in camera-type eye', 'sympathetic nervous system development', 'ureteric bud development', 'ureteric bud formation']['branching involved in ureteric bud morphogenesis', 'cell population proliferation', 'cellular response to dexamethasone stimulus', 'commissural neuron axon guidance', 'dorsal spinal cord development', 'embryonic organ development', 'enteric nervous system development', 'male gonad development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'metanephros development', 'midbrain development', 'mRNA stabilization', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of neuron apoptotic process', 'nervous system development', 'neural crest cell migration', 'neuron differentiation', 'neuron projection development', 'organ induction', 'peripheral nervous system development', 'peristalsis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis', 'positive regulation of monooxygenase activity', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of ureteric bud formation', 'postganglionic parasympathetic fiber development', 'postsynaptic membrane organization', 'regulation of dopamine uptake involved in synaptic transmission', 'regulation of gene expression', 'regulation of morphogenesis of a branching structure', 'regulation of semaphorin-plexin signaling pathway', 'regulation of ureteric bud formation', 'response to wounding', 'retina development in camera-type eye', 'sympathetic nervous system development', 'ureteric bud development', 'ureteric bud formation']
Growth/differentiation factor 5
400
Growth/differentiation factor 5
465
9.8
77
0.13
P43026P43026['BMP signaling pathway', 'cell-cell signaling', 'chondroblast differentiation', 'chondrocyte differentiation', 'embryonic limb morphogenesis', 'forelimb morphogenesis', 'hindlimb morphogenesis', 'mesenchymal cell apoptotic process', 'negative regulation of chondrocyte differentiation', 'negative regulation of epithelial cell proliferation', 'negative regulation of mesenchymal cell apoptotic process', 'negative regulation of neuron apoptotic process', 'ossification involved in bone remodeling', 'positive regulation of BMP signaling pathway', 'positive regulation of chondrocyte differentiation', 'positive regulation of neuron differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'regulation of multicellular organism growth', 'regulation of SMAD protein signal transduction', 'response to mechanical stimulus', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['BMP signaling pathway', 'cell-cell signaling', 'chondroblast differentiation', 'chondrocyte differentiation', 'embryonic limb morphogenesis', 'forelimb morphogenesis', 'hindlimb morphogenesis', 'mesenchymal cell apoptotic process', 'negative regulation of chondrocyte differentiation', 'negative regulation of epithelial cell proliferation', 'negative regulation of mesenchymal cell apoptotic process', 'negative regulation of neuron apoptotic process', 'ossification involved in bone remodeling', 'positive regulation of BMP signaling pathway', 'positive regulation of chondrocyte differentiation', 'positive regulation of neuron differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'regulation of multicellular organism growth', 'regulation of SMAD protein signal transduction', 'response to mechanical stimulus', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
Mitochondrial antiviral-signaling protein
20
Mitochondrial antiviral-signaling protein
79
9.7
51
0.2
Q7Z434Q7Z434['activation of innate immune response', 'cellular response to exogenous dsRNA', 'defense response to bacterium', 'defense response to virus', 'innate immune response', 'negative regulation of viral genome replication', 'positive regulation of chemokine (C-C motif) ligand 5 production', 'positive regulation of defense response to virus by host', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interferon-alpha production', 'positive regulation of interferon-beta production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of IP-10 production', 'positive regulation of myeloid dendritic cell cytokine production', 'positive regulation of protein import into nucleus', 'positive regulation of protein phosphorylation', 'positive regulation of response to cytokine stimulus', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'positive regulation of type I interferon-mediated signaling pathway', 'regulation of peroxisome organization', 'signal transduction', 'type I interferon signaling pathway']['activation of innate immune response', 'cellular response to exogenous dsRNA', 'defense response to bacterium', 'defense response to virus', 'innate immune response', 'negative regulation of viral genome replication', 'positive regulation of chemokine (C-C motif) ligand 5 production', 'positive regulation of defense response to virus by host', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interferon-alpha production', 'positive regulation of interferon-beta production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of IP-10 production', 'positive regulation of myeloid dendritic cell cytokine production', 'positive regulation of protein import into nucleus', 'positive regulation of protein phosphorylation', 'positive regulation of response to cytokine stimulus', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'positive regulation of type I interferon-mediated signaling pathway', 'regulation of peroxisome organization', 'signal transduction', 'type I interferon signaling pathway']
ETS translocation variant 4
422
ETS translocation variant 4
422
2.0
60
0.82
P43268P43268['cell differentiation', 'positive regulation of keratinocyte differentiation', 'positive regulation of transcription by RNA polymerase II', 'regulation of transcription by RNA polymerase II']['cell differentiation', 'positive regulation of keratinocyte differentiation', 'positive regulation of transcription by RNA polymerase II', 'regulation of transcription by RNA polymerase II']
DNA-directed RNA polymerase, mitochondrial
591
Dimethyladenosine transferase 2, mitochondrial
383
9.8
48
0.21
O00411Q9H5Q4['mitochondrial transcription', 'transcription initiation from mitochondrial promoter']['mitochondrial transcription', 'rRNA methylation', 'transcription initiation from mitochondrial promoter']
Ryanodine receptor 3
852
Ryanodine receptor 3
852
2.0
62
0.79
Q15413Q15413['calcium ion transmembrane transport', 'calcium ion transport', 'cellular calcium ion homeostasis', 'cellular response to ATP', 'cellular response to caffeine', 'cellular response to calcium ion', 'cellular response to magnesium ion', 'protein homotetramerization']['calcium ion transmembrane transport', 'calcium ion transport', 'cellular calcium ion homeostasis', 'cellular response to ATP', 'cellular response to caffeine', 'cellular response to calcium ion', 'cellular response to magnesium ion', 'protein homotetramerization']
Isoform L-VEGF206 of Vascular endothelial growth factor A
310
Isoform L-VEGF206 of Vascular endothelial growth factor A
257
9.6
60
0.17
P15692-14P15692-14[][]
Thymidylate synthase
43
Thymidylate synthase
43
9.7
52
0.2
P04818P04818['aging', 'cartilage development', 'circadian rhythm', 'developmental growth', 'DNA biosynthetic process', 'dTMP biosynthetic process', 'dTTP biosynthetic process', 'intestinal epithelial cell maturation', 'liver regeneration', 'methylation', 'negative regulation of translation', 'response to cytokine', 'response to ethanol', 'response to folic acid', 'response to glucocorticoid', 'response to organophosphorus', 'response to progesterone', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'tetrahydrofolate interconversion', 'uracil metabolic process']['aging', 'cartilage development', 'circadian rhythm', 'developmental growth', 'DNA biosynthetic process', 'dTMP biosynthetic process', 'dTTP biosynthetic process', 'intestinal epithelial cell maturation', 'liver regeneration', 'methylation', 'negative regulation of translation', 'response to cytokine', 'response to ethanol', 'response to folic acid', 'response to glucocorticoid', 'response to organophosphorus', 'response to progesterone', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'tetrahydrofolate interconversion', 'uracil metabolic process']
NKG2-D type II integral membrane protein
112
NKG2-D type II integral membrane protein
126
9.6
78
0.13
O54709O54709['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of apoptotic process', 'positive regulation of interferon-gamma production', 'positive regulation of myeloid dendritic cell activation', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target', 'positive regulation of nitric oxide biosynthetic process', 'stimulatory C-type lectin receptor signaling pathway']['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of apoptotic process', 'positive regulation of interferon-gamma production', 'positive regulation of myeloid dendritic cell activation', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target', 'positive regulation of nitric oxide biosynthetic process', 'stimulatory C-type lectin receptor signaling pathway']
Phosphatidylinositide phosphatase SAC2
725
Phosphatidylinositide phosphatase SAC2
725
2.0
57
0.87
Q9Y2H2Q9Y2H2['adult locomotory behavior', 'cardiac muscle hypertrophy in response to stress', 'clathrin-dependent endocytosis', 'negative regulation of axon regeneration', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of tyrosine phosphorylation of STAT protein', 'phosphatidylinositol biosynthetic process', 'phosphatidylinositol catabolic process', 'phosphatidylinositol dephosphorylation', 'phosphatidylinositol-mediated signaling', 'positive regulation of receptor recycling', 'regulation of cell motility', 'regulation of endocytic recycling', 'regulation of protein kinase B signaling']['adult locomotory behavior', 'cardiac muscle hypertrophy in response to stress', 'clathrin-dependent endocytosis', 'negative regulation of axon regeneration', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of tyrosine phosphorylation of STAT protein', 'phosphatidylinositol biosynthetic process', 'phosphatidylinositol catabolic process', 'phosphatidylinositol dephosphorylation', 'phosphatidylinositol-mediated signaling', 'positive regulation of receptor recycling', 'regulation of cell motility', 'regulation of endocytic recycling', 'regulation of protein kinase B signaling']
Angiotensinogen
340
Angiotensinogen
340
2.0
60
0.83
P11859P11859['activation of NF-kappaB-inducing kinase activity', 'activation of phospholipase C activity', 'aldosterone secretion', 'angiotensin-activated signaling pathway', 'angiotensin-mediated drinking behavior', 'angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure', 'artery smooth muscle contraction', 'associative learning', 'astrocyte activation', 'blood vessel development', 'brain renin-angiotensin system', 'branching involved in ureteric bud morphogenesis', 'cell growth involved in cardiac muscle cell development', 'cell population proliferation', 'cell surface receptor signaling pathway', 'cell-matrix adhesion', 'cellular sodium ion homeostasis', 'drinking behavior', 'ERK1 and ERK2 cascade', 'establishment of blood-nerve barrier', 'extracellular matrix organization', 'fibroblast proliferation', 'G protein-coupled receptor signaling pathway', 'hormone metabolic process', 'kidney development', 'MAPK cascade', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of endopeptidase activity', 'negative regulation of gene expression', 'negative regulation of MAP kinase activity', 'negative regulation of neuron apoptotic process', 'negative regulation of neurotrophin TRK receptor signaling pathway', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of tissue remodeling', 'negative regulation of vascular associated smooth muscle cell proliferation', 'neuron apoptotic process', 'operant conditioning', 'organ growth', 'ovarian follicle rupture', 'peristalsis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of blood pressure', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of catalytic activity', 'positive regulation of cell population proliferation', 'positive regulation of CoA-transferase activity', 'positive regulation of cytokine production', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of endothelial cell migration', 'positive regulation of epidermal growth factor receptor signaling pathway', 'positive regulation of extracellular matrix constituent secretion', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of fatty acid biosynthetic process', 'positive regulation of fibroblast proliferation', 'positive regulation of gap junction assembly', 'positive regulation of gene expression', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of L-arginine import across plasma membrane', 'positive regulation of L-lysine import across plasma membrane', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of MAPK cascade', 'positive regulation of membrane hyperpolarization', 'positive regulation of multicellular organism growth', 'positive regulation of neuron projection development', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of organ growth', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase C activity', 'positive regulation of protein metabolic process', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of renal sodium excretion', 'positive regulation of superoxide anion generation', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular associated smooth muscle cell migration', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein import into nucleus', 'regulation of apoptotic process', 'regulation of blood pressure', 'regulation of calcium ion transport', 'regulation of cardiac conduction', 'regulation of extracellular matrix assembly', 'regulation of gene expression', 'regulation of heart rate', 'regulation of inflammatory response', 'regulation of long-term neuronal synaptic plasticity', 'regulation of norepinephrine secretion', 'regulation of renal output by angiotensin', 'regulation of renal sodium excretion', 'regulation of systemic arterial blood pressure by circulatory renin-angiotensin', 'regulation of transmission of nerve impulse', 'renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure', 'renal system process', 'renin-angiotensin regulation of aldosterone production', 'response to cold', 'response to muscle activity involved in regulation of muscle adaptation', 'response to salt stress', 'smooth muscle cell differentiation', 'smooth muscle cell proliferation', 'stress-activated MAPK cascade', 'uterine smooth muscle contraction', 'vascular associated smooth muscle cell proliferation', 'vasoconstriction', 'vasodilation', 'vasopressin secretion']['activation of NF-kappaB-inducing kinase activity', 'activation of phospholipase C activity', 'aldosterone secretion', 'angiotensin-activated signaling pathway', 'angiotensin-mediated drinking behavior', 'angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure', 'artery smooth muscle contraction', 'associative learning', 'astrocyte activation', 'blood vessel development', 'brain renin-angiotensin system', 'branching involved in ureteric bud morphogenesis', 'cell growth involved in cardiac muscle cell development', 'cell population proliferation', 'cell surface receptor signaling pathway', 'cell-matrix adhesion', 'cellular sodium ion homeostasis', 'drinking behavior', 'ERK1 and ERK2 cascade', 'establishment of blood-nerve barrier', 'extracellular matrix organization', 'fibroblast proliferation', 'G protein-coupled receptor signaling pathway', 'hormone metabolic process', 'kidney development', 'MAPK cascade', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of endopeptidase activity', 'negative regulation of gene expression', 'negative regulation of MAP kinase activity', 'negative regulation of neuron apoptotic process', 'negative regulation of neurotrophin TRK receptor signaling pathway', 'negative regulation of smooth muscle cell proliferation', 'negative regulation of tissue remodeling', 'negative regulation of vascular associated smooth muscle cell proliferation', 'neuron apoptotic process', 'operant conditioning', 'organ growth', 'ovarian follicle rupture', 'peristalsis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of blood pressure', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of catalytic activity', 'positive regulation of cell population proliferation', 'positive regulation of CoA-transferase activity', 'positive regulation of cytokine production', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of endothelial cell migration', 'positive regulation of epidermal growth factor receptor signaling pathway', 'positive regulation of extracellular matrix constituent secretion', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of fatty acid biosynthetic process', 'positive regulation of fibroblast proliferation', 'positive regulation of gap junction assembly', 'positive regulation of gene expression', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of L-arginine import across plasma membrane', 'positive regulation of L-lysine import across plasma membrane', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of MAPK cascade', 'positive regulation of membrane hyperpolarization', 'positive regulation of multicellular organism growth', 'positive regulation of neuron projection development', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of organ growth', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase C activity', 'positive regulation of protein metabolic process', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of renal sodium excretion', 'positive regulation of superoxide anion generation', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular associated smooth muscle cell migration', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein import into nucleus', 'regulation of apoptotic process', 'regulation of blood pressure', 'regulation of calcium ion transport', 'regulation of cardiac conduction', 'regulation of extracellular matrix assembly', 'regulation of gene expression', 'regulation of heart rate', 'regulation of inflammatory response', 'regulation of long-term neuronal synaptic plasticity', 'regulation of norepinephrine secretion', 'regulation of renal output by angiotensin', 'regulation of renal sodium excretion', 'regulation of systemic arterial blood pressure by circulatory renin-angiotensin', 'regulation of transmission of nerve impulse', 'renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure', 'renal system process', 'renin-angiotensin regulation of aldosterone production', 'response to cold', 'response to muscle activity involved in regulation of muscle adaptation', 'response to salt stress', 'smooth muscle cell differentiation', 'smooth muscle cell proliferation', 'stress-activated MAPK cascade', 'uterine smooth muscle contraction', 'vascular associated smooth muscle cell proliferation', 'vasoconstriction', 'vasodilation', 'vasopressin secretion']
Rho guanine nucleotide exchange factor TIAM2
592
Rho guanine nucleotide exchange factor TIAM2
564
9.7
67
0.15
Q6ZPF3Q6ZPF3['activation of GTPase activity', 'positive regulation of axonogenesis', 'small GTPase mediated signal transduction']['activation of GTPase activity', 'positive regulation of axonogenesis', 'small GTPase mediated signal transduction']
Acrosin
152
Acrosin
22
2.0
67
0.74
P08001P08001['acrosome reaction', 'activation of adenylate cyclase activity', 'proteolysis', 'single fertilization']['acrosome reaction', 'activation of adenylate cyclase activity', 'proteolysis', 'single fertilization']
Vascular endothelial growth factor A
77
Vascular endothelial growth factor A
130
9.6
70
0.15
Q96NW5Q96NW5['activation of protein kinase activity', 'angiogenesis', 'artery morphogenesis', 'basophil chemotaxis', 'branching involved in blood vessel morphogenesis', 'camera-type eye morphogenesis', 'cardiac muscle cell development', 'cardiac vascular smooth muscle cell development', 'cell maturation', 'cell migration involved in sprouting angiogenesis', 'cellular response to hypoxia', 'cellular response to vascular endothelial growth factor stimulus', 'cellular stress response to acid chemical', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'coronary vein morphogenesis', 'dopaminergic neuron differentiation', 'endothelial cell chemotaxis', 'epithelial cell differentiation', 'eye photoreceptor cell development', 'heart morphogenesis', 'in utero embryonic development', 'induction of positive chemotaxis', 'kidney development', 'lactation', 'lung development', 'lymph vessel morphogenesis', 'macrophage differentiation', 'mammary gland alveolus development', 'mesoderm development', 'monocyte differentiation', 'motor neuron migration', 'negative regulation of adherens junction organization', 'negative regulation of apoptotic process', 'negative regulation of blood-brain barrier permeability', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of establishment of endothelial barrier', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'outflow tract morphogenesis', 'ovarian follicle development', 'positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell migration by vascular endothelial growth factor signaling pathway', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway', 'positive regulation of cold-induced thermogenesis', 'positive regulation of CREB transcription factor activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of histone deacetylase activity', 'positive regulation of leukocyte migration', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of neuroblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of positive chemotaxis', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C signaling', 'positive regulation of protein kinase D signaling', 'positive regulation of protein localization to early endosome', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor internalization', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of trophoblast cell migration', 'positive regulation of vascular permeability', 'post-embryonic camera-type eye development', 'primitive erythrocyte differentiation', 'regulation of cell shape', 'regulation of nitric oxide mediated signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of transcription by RNA polymerase II', 'response to hypoxia', 'sprouting angiogenesis', 'surfactant homeostasis', 'tube formation', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway']['activation of protein kinase activity', 'angiogenesis', 'artery morphogenesis', 'basophil chemotaxis', 'branching involved in blood vessel morphogenesis', 'camera-type eye morphogenesis', 'cardiac muscle cell development', 'cardiac vascular smooth muscle cell development', 'cell maturation', 'cell migration involved in sprouting angiogenesis', 'cellular response to hypoxia', 'cellular response to vascular endothelial growth factor stimulus', 'cellular stress response to acid chemical', 'commissural neuron axon guidance', 'coronary artery morphogenesis', 'coronary vein morphogenesis', 'dopaminergic neuron differentiation', 'endothelial cell chemotaxis', 'epithelial cell differentiation', 'eye photoreceptor cell development', 'heart morphogenesis', 'in utero embryonic development', 'induction of positive chemotaxis', 'kidney development', 'lactation', 'lung development', 'lymph vessel morphogenesis', 'macrophage differentiation', 'mammary gland alveolus development', 'mesoderm development', 'monocyte differentiation', 'motor neuron migration', 'negative regulation of adherens junction organization', 'negative regulation of apoptotic process', 'negative regulation of blood-brain barrier permeability', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of establishment of endothelial barrier', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'outflow tract morphogenesis', 'ovarian follicle development', 'positive chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell migration by vascular endothelial growth factor signaling pathway', 'positive regulation of cell migration involved in sprouting angiogenesis', 'positive regulation of cell population proliferation', 'positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway', 'positive regulation of cold-induced thermogenesis', 'positive regulation of CREB transcription factor activity', 'positive regulation of DNA biosynthetic process', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of epithelial tube formation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of histone deacetylase activity', 'positive regulation of leukocyte migration', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell chemotaxis', 'positive regulation of neuroblast proliferation', 'positive regulation of p38MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of positive chemotaxis', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C signaling', 'positive regulation of protein kinase D signaling', 'positive regulation of protein localization to early endosome', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor internalization', 'positive regulation of retinal ganglion cell axon guidance', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of trophoblast cell migration', 'positive regulation of vascular permeability', 'post-embryonic camera-type eye development', 'primitive erythrocyte differentiation', 'regulation of cell shape', 'regulation of nitric oxide mediated signal transduction', 'regulation of retinal ganglion cell axon guidance', 'regulation of transcription by RNA polymerase II', 'response to hypoxia', 'sprouting angiogenesis', 'surfactant homeostasis', 'tube formation', 'vascular endothelial growth factor receptor signaling pathway', 'vascular endothelial growth factor receptor-2 signaling pathway', 'vascular endothelial growth factor signaling pathway', 'vascular wound healing', 'vasculogenesis', 'VEGF-activated neuropilin signaling pathway']
Protein FAM3C
64
Protein FAM3C
221
2.0
57
0.86
Q91VU0Q91VU0['negative regulation of gluconeogenesis']['negative regulation of gluconeogenesis']
Protein S100-A4
76
Protein S100-A4
76
9.9
78
0.13
P26447P26447['epithelial to mesenchymal transition', 'positive regulation of I-kappaB kinase/NF-kappaB signaling']['epithelial to mesenchymal transition', 'positive regulation of I-kappaB kinase/NF-kappaB signaling']
Transforming growth factor beta-1 proprotein
33
Transforming growth factor beta activator LRRC32
211
2.0
85
0.58
P01137Q14392['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['negative regulation of activated T cell proliferation', 'negative regulation of cytokine production', 'positive regulation of gene expression', 'regulation of transforming growth factor beta activation', 'regulation of transforming growth factor beta3 activation', 'secondary palate development', 'transforming growth factor beta receptor signaling pathway']
Endothelin-1
55
Endothelin-1
55
9.9
54
0.19
P05305P05305['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'artery smooth muscle contraction', 'axon extension', 'axonogenesis involved in innervation', 'body fluid secretion', 'branching involved in blood vessel morphogenesis', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cardiac neural crest cell migration involved in outflow tract morphogenesis', 'cartilage development', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to calcium ion', 'cellular response to fatty acid', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to human chorionic gonadotropin stimulus', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to luteinizing hormone stimulus', 'cellular response to mineralocorticoid stimulus', 'cellular response to organic substance', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to xenobiotic stimulus', 'dorsal/ventral pattern formation', 'embryonic heart tube development', 'endothelin receptor signaling pathway', 'endothelin receptor signaling pathway involved in heart process', 'epithelial fluid transport', 'ERK1 and ERK2 cascade', 'G protein-coupled receptor signaling pathway', 'histamine secretion', 'I-kappaB kinase/NF-kappaB signaling', 'in utero embryonic development', 'inositol phosphate-mediated signaling', 'leukocyte activation', 'maternal process involved in parturition', 'meiotic cell cycle process involved in oocyte maturation', 'membrane depolarization', 'middle ear morphogenesis', 'mitochondrion organization', 'multicellular organism aging', 'negative regulation of blood coagulation', 'negative regulation of gene expression', 'negative regulation of hormone secretion', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein metabolic process', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'neural crest cell fate commitment', 'nitric oxide transport', 'noradrenergic neuron differentiation', 'peptide hormone secretion', 'pharyngeal arch artery morphogenesis', 'phosphatidylinositol 3-kinase signaling', 'phospholipase D-activating G protein-coupled receptor signaling pathway', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cation channel activity', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell size', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell migration', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of JUN kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of odontogenesis', 'positive regulation of prostaglandin secretion', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'positive regulation of renal sodium excretion', 'positive regulation of sarcomere organization', 'positive regulation of signaling receptor activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'prostaglandin biosynthetic process', 'protein kinase A signaling', 'protein kinase C deactivation', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'regulation of glucose transmembrane transport', 'regulation of pH', 'regulation of sensory perception of pain', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'renal sodium ion absorption', 'respiratory gaseous exchange by respiratory system', 'response to activity', 'response to amino acid', 'response to amphetamine', 'response to dexamethasone', 'response to leptin', 'response to lipopolysaccharide', 'response to muscle stretch', 'response to nicotine', 'response to ozone', 'response to prostaglandin F', 'response to salt', 'response to testosterone', 'rhythmic excitation', 'semaphorin-plexin signaling pathway involved in axon guidance', 'sensory perception of pain', 'superoxide anion generation', 'sympathetic neuron axon guidance', 'thyroid gland development', 'transcription by RNA polymerase II', 'vasoconstriction', 'vein smooth muscle contraction']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'artery smooth muscle contraction', 'axon extension', 'axonogenesis involved in innervation', 'body fluid secretion', 'branching involved in blood vessel morphogenesis', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cardiac neural crest cell migration involved in outflow tract morphogenesis', 'cartilage development', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to calcium ion', 'cellular response to fatty acid', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to human chorionic gonadotropin stimulus', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to luteinizing hormone stimulus', 'cellular response to mineralocorticoid stimulus', 'cellular response to organic substance', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to xenobiotic stimulus', 'dorsal/ventral pattern formation', 'embryonic heart tube development', 'endothelin receptor signaling pathway', 'endothelin receptor signaling pathway involved in heart process', 'epithelial fluid transport', 'ERK1 and ERK2 cascade', 'G protein-coupled receptor signaling pathway', 'histamine secretion', 'I-kappaB kinase/NF-kappaB signaling', 'in utero embryonic development', 'inositol phosphate-mediated signaling', 'leukocyte activation', 'maternal process involved in parturition', 'meiotic cell cycle process involved in oocyte maturation', 'membrane depolarization', 'middle ear morphogenesis', 'mitochondrion organization', 'multicellular organism aging', 'negative regulation of blood coagulation', 'negative regulation of gene expression', 'negative regulation of hormone secretion', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein metabolic process', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'neural crest cell fate commitment', 'nitric oxide transport', 'noradrenergic neuron differentiation', 'peptide hormone secretion', 'pharyngeal arch artery morphogenesis', 'phosphatidylinositol 3-kinase signaling', 'phospholipase D-activating G protein-coupled receptor signaling pathway', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cation channel activity', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell size', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell migration', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of JUN kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of odontogenesis', 'positive regulation of prostaglandin secretion', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'positive regulation of renal sodium excretion', 'positive regulation of sarcomere organization', 'positive regulation of signaling receptor activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'prostaglandin biosynthetic process', 'protein kinase A signaling', 'protein kinase C deactivation', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'regulation of glucose transmembrane transport', 'regulation of pH', 'regulation of sensory perception of pain', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'renal sodium ion absorption', 'respiratory gaseous exchange by respiratory system', 'response to activity', 'response to amino acid', 'response to amphetamine', 'response to dexamethasone', 'response to leptin', 'response to lipopolysaccharide', 'response to muscle stretch', 'response to nicotine', 'response to ozone', 'response to prostaglandin F', 'response to salt', 'response to testosterone', 'rhythmic excitation', 'semaphorin-plexin signaling pathway involved in axon guidance', 'sensory perception of pain', 'superoxide anion generation', 'sympathetic neuron axon guidance', 'thyroid gland development', 'transcription by RNA polymerase II', 'vasoconstriction', 'vein smooth muscle contraction']
Peroxynitrite isomerase THAP4
483
Peroxynitrite isomerase THAP4
483
3.4
86
0.34
Q8WY91Q8WY91['nitrate metabolic process', 'tyrosine metabolic process']['nitrate metabolic process', 'tyrosine metabolic process']
Trypsin-3
105
Tissue factor pathway inhibitor
63
9.1
99
0.11
P35030P10646['antimicrobial humoral response', 'digestion', 'endothelial cell migration', 'proteolysis', 'zymogen activation']['blood coagulation', 'cellular response to steroid hormone stimulus', 'negative regulation of blood coagulation']
C-C motif chemokine 3
33
C-C motif chemokine 3
33
3.9
77
0.33
P10147P10147['astrocyte cell migration', 'calcium ion transport', 'calcium-mediated signaling', 'cell activation', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytoskeleton organization', 'eosinophil chemotaxis', 'eosinophil degranulation', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'granulocyte chemotaxis', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'negative regulation of osteoclast differentiation', 'neutrophil chemotaxis', 'osteoblast differentiation', 'positive regulation of calcium ion import', 'positive regulation of calcium ion transport', 'positive regulation of calcium-mediated signaling', 'positive regulation of cell migration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of GTPase activity', 'positive regulation of inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of microglial cell activation', 'positive regulation of microglial cell migration', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of protein kinase B signaling', 'positive regulation of tumor necrosis factor production', 'protein kinase B signaling', 'regulation of behavior', 'regulation of cell shape', 'regulation of sensory perception of pain', 'release of sequestered calcium ion into cytosol by sarcoplasmic reticulum', 'response to cholesterol', 'response to toxic substance', 'signaling', 'T cell chemotaxis']['astrocyte cell migration', 'calcium ion transport', 'calcium-mediated signaling', 'cell activation', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytoskeleton organization', 'eosinophil chemotaxis', 'eosinophil degranulation', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'granulocyte chemotaxis', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'negative regulation of osteoclast differentiation', 'neutrophil chemotaxis', 'osteoblast differentiation', 'positive regulation of calcium ion import', 'positive regulation of calcium ion transport', 'positive regulation of calcium-mediated signaling', 'positive regulation of cell migration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of GTPase activity', 'positive regulation of inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of microglial cell activation', 'positive regulation of microglial cell migration', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of protein kinase B signaling', 'positive regulation of tumor necrosis factor production', 'protein kinase B signaling', 'regulation of behavior', 'regulation of cell shape', 'regulation of sensory perception of pain', 'release of sequestered calcium ion into cytosol by sarcoplasmic reticulum', 'response to cholesterol', 'response to toxic substance', 'signaling', 'T cell chemotaxis']
Neutrophil defensin 3
83
Neutrophil defensin 3
94
9.2
nan
nan
P59666P59666['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to virus', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing of cells of another organism', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to virus', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing of cells of another organism', 'membrane disruption in another organism']
Interleukin-6 receptor subunit alpha
121
Interleukin-6 receptor subunit alpha
165
9.7
62
0.17
P08887P08887['acute-phase response', 'ciliary neurotrophic factor-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'endocrine pancreas development', 'extrinsic apoptotic signaling pathway', 'hepatic immune response', 'interleukin-6-mediated signaling pathway', 'monocyte chemotaxis', 'negative regulation of collagen biosynthetic process', 'negative regulation of interleukin-8 production', 'neutrophil mediated immunity', 'positive regulation of activation of Janus kinase activity', 'positive regulation of cell population proliferation', 'positive regulation of chemokine production', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of interleukin-6 production', 'positive regulation of leukocyte chemotaxis', 'positive regulation of MAPK cascade', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of platelet aggregation', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'response to cytokine', 'T-helper 17 cell lineage commitment', 'vascular endothelial growth factor production']['acute-phase response', 'ciliary neurotrophic factor-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'endocrine pancreas development', 'extrinsic apoptotic signaling pathway', 'hepatic immune response', 'interleukin-6-mediated signaling pathway', 'monocyte chemotaxis', 'negative regulation of collagen biosynthetic process', 'negative regulation of interleukin-8 production', 'neutrophil mediated immunity', 'positive regulation of activation of Janus kinase activity', 'positive regulation of cell population proliferation', 'positive regulation of chemokine production', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of interleukin-6 production', 'positive regulation of leukocyte chemotaxis', 'positive regulation of MAPK cascade', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of platelet aggregation', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'response to cytokine', 'T-helper 17 cell lineage commitment', 'vascular endothelial growth factor production']
Cryptochrome-1
414
Period circadian protein homolog 2
1210
3.3
74
0.41
P97784O54943['circadian regulation of gene expression', 'circadian rhythm', 'DNA damage induced protein phosphorylation', 'entrainment of circadian clock by photoperiod', 'gluconeogenesis', 'glucose homeostasis', 'lipid storage', 'negative regulation of circadian rhythm', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of glucocorticoid receptor signaling pathway', 'negative regulation of glucocorticoid secretion', 'negative regulation of gluconeogenesis', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of protein ubiquitination', 'regulation of circadian rhythm', 'regulation of DNA damage checkpoint', 'response to activity', 'response to glucagon', 'response to insulin', 'response to light stimulus']['circadian regulation of gene expression', 'circadian regulation of translation', 'circadian rhythm', 'entrainment of circadian clock by photoperiod', 'fatty acid metabolic process', 'gluconeogenesis', 'glycogen biosynthetic process', 'histone H3 deacetylation', 'lactate biosynthetic process', 'negative regulation of circadian rhythm', 'negative regulation of DNA-templated transcription, termination', 'negative regulation of fat cell proliferation', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription regulatory region DNA binding', 'negative regulation of transcription, DNA-templated', 'positive regulation of cold-induced thermogenesis', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of glutamate uptake involved in transmission of nerve impulse', 'regulation of insulin secretion', 'regulation of neurogenesis', 'regulation of vasoconstriction', 'response to ischemia', 'white fat cell differentiation']
Pancreatic trypsin inhibitor
40
Pancreatic trypsin inhibitor
86
7.4
60
0.23
P00974P00974['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Thioredoxin-interacting protein
247
Thioredoxin
32
2.2
81
0.57
Q9H3M7P10599['cell cycle', 'cellular response to tumor cell', 'keratinocyte differentiation', 'negative regulation of cell division', 'negative regulation of transcription by RNA polymerase II', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of apoptotic process', 'protein import into nucleus', 'protein transport', 'regulation of cell population proliferation', 'response to calcium ion', 'response to estradiol', 'response to glucose', 'response to hydrogen peroxide', 'response to mechanical stimulus', 'response to progesterone', 'response to xenobiotic stimulus']['activation of protein kinase B activity', 'cell redox homeostasis', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of protein export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA binding', 'positive regulation of peptidyl-cysteine S-nitrosylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'response to nitric oxide', 'response to radiation']
PRSS3 protein
68
Amyloid-beta precursor protein
324
9.7
86
0.12
Q8N2U3P05067['proteolysis']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Frizzled-8
107
Frizzled-8
148
9.7
75
0.14
Q61091Q61091['angiogenesis', 'canonical Wnt signaling pathway', 'positive regulation of JUN kinase activity', 'positive regulation of protein phosphorylation', 'T cell differentiation in thymus', 'Wnt signaling pathway']['angiogenesis', 'canonical Wnt signaling pathway', 'positive regulation of JUN kinase activity', 'positive regulation of protein phosphorylation', 'T cell differentiation in thymus', 'Wnt signaling pathway']
Hepcidin
81
Neutrophil gelatinase-associated lipocalin
195
7.4
76
0.18
P81172P80188['acute-phase response', 'aging', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular iron ion homeostasis', 'cellular response to bile acid', 'cellular response to interleukin-6', 'cellular response to lipopolysaccharide', 'cellular response to tumor necrosis factor', 'cellular response to X-ray', 'defense response to bacterium', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'establishment of localization in cell', 'immune response', 'iron ion transmembrane transport', 'killing of cells of another organism', 'liver regeneration', 'macrophage activation', 'multicellular organismal iron ion homeostasis', 'myeloid cell homeostasis', 'negative regulation of bone resorption', 'negative regulation of inflammatory response', 'negative regulation of intestinal absorption', 'negative regulation of ion transmembrane transporter activity', 'negative regulation of iron export across plasma membrane', 'negative regulation of iron ion transmembrane transport', 'negative regulation of iron ion transmembrane transporter activity', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of macrophage activation', 'positive regulation of protein catabolic process', 'positive regulation of protein polyubiquitination', 'positive regulation of receptor catabolic process', 'positive regulation of receptor internalization', 'positive regulation of transcription by RNA polymerase II', 'protein catabolic process', 'receptor signaling pathway via JAK-STAT', 'response to erythropoietin', 'response to ethanol', 'response to iron ion', 'response to iron ion starvation', 'response to vitamin A', 'response to zinc ion', 'transcription by RNA polymerase II']['apoptotic process', 'defense response to bacterium', 'innate immune response', 'positive regulation of cold-induced thermogenesis', 'sequestering of iron ion', 'siderophore transport']
Aphrodisin
54
Aphrodisin
58
3.1
45
0.72
P09465P09465[][]
Interleukin-17F
154
Interleukin-17F
154
7.4
95
0.14
Q96PD4Q96PD4['adaptive immune response', 'cartilage development', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'inflammatory response', 'innate immune response', 'interleukin-17-mediated signaling pathway', 'negative regulation of angiogenesis', 'positive regulation of antimicrobial peptide production', 'positive regulation of chemokine (C-X-C motif) ligand 1 production', 'positive regulation of cytokine production', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of interleukin-6 production', 'positive regulation of lymphotoxin A production', 'positive regulation of transcription by RNA polymerase II', 'regulation of granulocyte macrophage colony-stimulating factor production', 'regulation of interleukin-2 production', 'regulation of interleukin-6 production', 'regulation of interleukin-8 production', 'regulation of transforming growth factor beta receptor signaling pathway']['adaptive immune response', 'cartilage development', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'inflammatory response', 'innate immune response', 'interleukin-17-mediated signaling pathway', 'negative regulation of angiogenesis', 'positive regulation of antimicrobial peptide production', 'positive regulation of chemokine (C-X-C motif) ligand 1 production', 'positive regulation of cytokine production', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of interleukin-6 production', 'positive regulation of lymphotoxin A production', 'positive regulation of transcription by RNA polymerase II', 'regulation of granulocyte macrophage colony-stimulating factor production', 'regulation of interleukin-2 production', 'regulation of interleukin-6 production', 'regulation of interleukin-8 production', 'regulation of transforming growth factor beta receptor signaling pathway']
Complement C5
711
Complement C5
699
9.3
68
0.16
P01031P01031['cell surface receptor signaling pathway', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'G protein-coupled receptor signaling pathway', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']['cell surface receptor signaling pathway', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'G protein-coupled receptor signaling pathway', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']
EKC/KEOPS complex subunit TPRKB
167
EKC/KEOPS complex subunit TPRKB
167
2.0
63
0.78
Q9Y3C4Q9Y3C4['telomere maintenance via recombination', 'tRNA threonylcarbamoyladenosine modification']['telomere maintenance via recombination', 'tRNA threonylcarbamoyladenosine modification']
C-type lectin domain family 2 member D11
80
C-type lectin domain family 2 member D11
91
9.6
79
0.13
Q0H8B9Q0H8B9[][]
Heat shock factor 2-binding protein
120
Heat shock factor 2-binding protein
120
2.0
62
0.79
O75031O75031['double-strand break repair involved in meiotic recombination', 'female meiosis I', 'male meiosis I', 'spermatogenesis', 'transcription by RNA polymerase II']['double-strand break repair involved in meiotic recombination', 'female meiosis I', 'male meiosis I', 'spermatogenesis', 'transcription by RNA polymerase II']
Mitotic spindle assembly checkpoint protein MAD2B
144
DNA polymerase zeta catalytic subunit
1999
10.0
60
0.17
Q9UI95O60673['actin filament organization', 'cell division', 'DNA damage response, signal transduction resulting in transcription', 'double-strand break repair', 'error-prone translesion synthesis', 'mitotic spindle assembly checkpoint signaling', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of double-strand break repair via homologous recombination', 'negative regulation of epithelial to mesenchymal transition', 'negative regulation of protein catabolic process', 'negative regulation of transcription by competitive promoter binding', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription regulatory region DNA binding', 'negative regulation of ubiquitin protein ligase activity', 'positive regulation of double-strand break repair via nonhomologous end joining', 'positive regulation of isotype switching', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of transcription, DNA-templated', 'regulation of cell growth', 'somatic diversification of immunoglobulins involved in immune response', 'telomere maintenance in response to DNA damage']['DNA-templated DNA replication', 'double-strand break repair via homologous recombination', 'error-prone translesion synthesis']
Prorelaxin H2
185
Prorelaxin H2
47
2.0
nan
nan
P04090P04090['female pregnancy', 'positive regulation of angiogenesis', 'positive regulation of gene expression', 'regulation of catalytic activity']['female pregnancy', 'positive regulation of angiogenesis', 'positive regulation of gene expression', 'regulation of catalytic activity']
Small nuclear ribonucleoprotein Sm D2
63
Small nuclear ribonucleoprotein F
66
6.8
79
0.19
P62316P62306['7-methylguanosine cap hypermethylation', 'mRNA splicing, via spliceosome', 'RNA splicing', 'spliceosomal complex assembly', 'spliceosomal snRNP assembly', 'U2-type prespliceosome assembly']['7-methylguanosine cap hypermethylation', 'mRNA splicing, via spliceosome', 'RNA splicing', 'spliceosomal snRNP assembly', 'U2-type prespliceosome assembly']
WD repeat-containing protein 48
200
Ubiquitin carboxyl-terminal hydrolase 12
48
6.7
68
0.22
Q8TAF3O75317['cellular response to DNA damage stimulus', 'double-strand break repair via homologous recombination', 'embryonic organ development', 'homeostasis of number of cells', 'multicellular organism growth', 'positive regulation of double-strand break repair via homologous recombination', 'positive regulation of epithelial cell proliferation', 'protein deubiquitination', 'regulation of protein monoubiquitination', 'seminiferous tubule development', 'single fertilization', 'skeletal system morphogenesis', 'skin development', 'spermatogenesis']['protein deubiquitination', 'ubiquitin-dependent protein catabolic process']
Protein cereblon
397
Protein cereblon
326
9.7
72
0.14
Q8C7D2Q8C7D2['locomotory exploration behavior', 'negative regulation of ion transmembrane transport', 'negative regulation of large conductance calcium-activated potassium channel activity', 'negative regulation of protein-containing complex assembly', 'positive regulation of protein-containing complex assembly', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination']['locomotory exploration behavior', 'negative regulation of ion transmembrane transport', 'negative regulation of large conductance calcium-activated potassium channel activity', 'negative regulation of protein-containing complex assembly', 'positive regulation of protein-containing complex assembly', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination']
IGK@ protein
235
Immunoglobulin heavy constant mu
14
2.0
nan
nan
Q6PJF2P01871[]['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
Protein fem-1 homolog B
186
Folliculin-interacting protein 1
613
3.7
54
0.5
Q9Z2G0Q68FD7['apoptotic process', 'branching involved in prostate gland morphogenesis', 'epithelial cell maturation', 'epithelial cell maturation involved in prostate gland development', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination', 'regulation of DNA damage checkpoint', 'regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'regulation of ubiquitin-protein transferase activity', 'ubiquitin-dependent protein catabolic process via the C-end degron rule pathway']['B cell apoptotic process', 'cellular response to starvation', 'immature B cell differentiation', 'negative regulation of cell population proliferation', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of TOR signaling', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of B cell apoptotic process', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of TOR signaling', 'regulation of pro-B cell differentiation', 'regulation of protein phosphorylation', 'TOR signaling']
Galectin-1
131
Galectin-1
131
3.5
64
0.44
P11762P11762['apoptotic process', 'cell-cell adhesion', 'cellular response to glucose stimulus', 'cellular response to organic cyclic compound', 'myoblast differentiation', 'negative regulation of cell-substrate adhesion', 'negative regulation of neuron projection development', 'plasma cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of erythrocyte aggregation', 'positive regulation of inflammatory response', 'positive regulation of viral entry into host cell', 'response to axon injury', 'response to isolation stress', 'response to xenobiotic stimulus', 'T cell costimulation']['apoptotic process', 'cell-cell adhesion', 'cellular response to glucose stimulus', 'cellular response to organic cyclic compound', 'myoblast differentiation', 'negative regulation of cell-substrate adhesion', 'negative regulation of neuron projection development', 'plasma cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of erythrocyte aggregation', 'positive regulation of inflammatory response', 'positive regulation of viral entry into host cell', 'response to axon injury', 'response to isolation stress', 'response to xenobiotic stimulus', 'T cell costimulation']
Mothers against decapentaplegic homolog 2
463
Mothers against decapentaplegic homolog 2
436
9.3
73
0.15
Q15796Q15796['activin receptor signaling pathway', 'adrenal gland development', 'anatomical structure morphogenesis', 'anterior/posterior pattern specification', 'BMP signaling pathway', 'cell differentiation', 'cell fate commitment', 'common-partner SMAD protein phosphorylation', 'embryonic cranial skeleton morphogenesis', 'embryonic foregut morphogenesis', 'endoderm formation', 'gastrulation', 'in utero embryonic development', 'insulin secretion', 'intracellular signal transduction', 'lung development', 'mesoderm formation', 'negative regulation of cell population proliferation', 'negative regulation of transcription, DNA-templated', 'nodal signaling pathway', 'organ growth', 'pancreas development', 'paraxial mesoderm morphogenesis', 'pericardium development', 'positive regulation of BMP signaling pathway', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of gene expression', 'positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'post-embryonic development', 'primary miRNA processing', 'regulation of binding', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to glucose', 'secondary palate development', 'signal transduction involved in regulation of gene expression', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transcription, DNA-templated', 'transforming growth factor beta receptor signaling pathway', 'ureteric bud development', 'wound healing', 'zygotic specification of dorsal/ventral axis']['activin receptor signaling pathway', 'adrenal gland development', 'anatomical structure morphogenesis', 'anterior/posterior pattern specification', 'BMP signaling pathway', 'cell differentiation', 'cell fate commitment', 'common-partner SMAD protein phosphorylation', 'embryonic cranial skeleton morphogenesis', 'embryonic foregut morphogenesis', 'endoderm formation', 'gastrulation', 'in utero embryonic development', 'insulin secretion', 'intracellular signal transduction', 'lung development', 'mesoderm formation', 'negative regulation of cell population proliferation', 'negative regulation of transcription, DNA-templated', 'nodal signaling pathway', 'organ growth', 'pancreas development', 'paraxial mesoderm morphogenesis', 'pericardium development', 'positive regulation of BMP signaling pathway', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of gene expression', 'positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'post-embryonic development', 'primary miRNA processing', 'regulation of binding', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to glucose', 'secondary palate development', 'signal transduction involved in regulation of gene expression', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transcription, DNA-templated', 'transforming growth factor beta receptor signaling pathway', 'ureteric bud development', 'wound healing', 'zygotic specification of dorsal/ventral axis']
PRSS3 protein
52
Amyloid-beta A4 protein
222
9.3
100
0.11
Q8N2U3H7C0V9['proteolysis']['nervous system development']
F-box/WD repeat-containing protein 11
145
S-phase kinase-associated protein 1
160
3.5
62
0.47
Q9UKB1P63208['brain morphogenesis', 'establishment of mitotic spindle orientation', 'germ cell development', 'microtubule organizing center organization', 'negative regulation of transcription, DNA-templated', 'nuclear migration', 'positive regulation of circadian rhythm', 'positive regulation of proteolysis', 'positive regulation of transcription, DNA-templated', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein dephosphorylation', 'protein destabilization', 'protein polyubiquitination', 'protein ubiquitination', 'retrograde axonal transport', 'rhythmic process', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process', 'vesicle transport along microtubule', 'Wnt signaling pathway']['histone H2A monoubiquitination', 'maintenance of protein location in nucleus', 'positive regulation of ubiquitin protein ligase activity', 'protein K48-linked ubiquitination', 'protein polyubiquitination', 'protein ubiquitination', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process']
CASP8-associated protein 2
83
CASP8-associated protein 2
83
3.4
45
0.65
Q9UKL3Q9UKL3['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'apoptotic signaling pathway', 'cell cycle', 'cellular response to mechanical stimulus', 'extrinsic apoptotic signaling pathway via death domain receptors', 'Fas signaling pathway', 'signal transduction']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'apoptotic signaling pathway', 'cell cycle', 'cellular response to mechanical stimulus', 'extrinsic apoptotic signaling pathway via death domain receptors', 'Fas signaling pathway', 'signal transduction']
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
414
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
408
9.1
79
0.14
Q9Y233Q9Y233['cAMP catabolic process', 'cGMP catabolic process', 'negative regulation of cGMP-mediated signaling', 'signal transduction']['cAMP catabolic process', 'cGMP catabolic process', 'negative regulation of cGMP-mediated signaling', 'signal transduction']
Geminin coiled-coil domain-containing protein 1
73
Geminin coiled-coil domain-containing protein 1
73
3.9
42
0.62
A6NCL1A6NCL1['cell cycle', 'cilium assembly', 'DNA replication initiation', 'negative regulation of cell cycle', 'negative regulation of DNA replication']['cell cycle', 'cilium assembly', 'DNA replication initiation', 'negative regulation of cell cycle', 'negative regulation of DNA replication']
Aldo-keto reductase family 1 member C21
7
Aldo-keto reductase family 1 member C21
7
9.1
79
0.14
Q91WR5Q91WR5['daunorubicin metabolic process', 'doxorubicin metabolic process', 'progesterone metabolic process', 'prostaglandin metabolic process', 'steroid biosynthetic process', 'steroid metabolic process']['daunorubicin metabolic process', 'doxorubicin metabolic process', 'progesterone metabolic process', 'prostaglandin metabolic process', 'steroid biosynthetic process', 'steroid metabolic process']
NAD kinase
349
NAD kinase
349
4.1
81
0.3
O95544O95544['ATP metabolic process', 'NAD metabolic process', 'NADP biosynthetic process', 'phosphorylation']['ATP metabolic process', 'NAD metabolic process', 'NADP biosynthetic process', 'phosphorylation']
Intercellular adhesion molecule 1
332
Intercellular adhesion molecule 1
332
9.1
73
0.15
P05362P05362['adhesion of symbiont to host', 'cell adhesion', 'cell adhesion mediated by integrin', 'cellular response to amyloid-beta', 'cellular response to glucose stimulus', 'cellular response to leukemia inhibitory factor', 'establishment of endothelial barrier', 'heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules', 'leukocyte cell-cell adhesion', 'leukocyte migration', 'membrane to membrane docking', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'positive regulation of cellular extravasation', 'positive regulation of ERK1 and ERK2 cascade', 'receptor-mediated virion attachment to host cell', 'regulation of leukocyte mediated cytotoxicity', 'regulation of ruffle assembly', 'T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell', 'T cell antigen processing and presentation', 'T cell extravasation']['adhesion of symbiont to host', 'cell adhesion', 'cell adhesion mediated by integrin', 'cellular response to amyloid-beta', 'cellular response to glucose stimulus', 'cellular response to leukemia inhibitory factor', 'establishment of endothelial barrier', 'heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules', 'leukocyte cell-cell adhesion', 'leukocyte migration', 'membrane to membrane docking', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'positive regulation of cellular extravasation', 'positive regulation of ERK1 and ERK2 cascade', 'receptor-mediated virion attachment to host cell', 'regulation of leukocyte mediated cytotoxicity', 'regulation of ruffle assembly', 'T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell', 'T cell antigen processing and presentation', 'T cell extravasation']
SOSS complex subunit B1
99
SOSS complex subunit B1
99
9.0
nan
nan
Q9BQ15Q9BQ15['cellular response to DNA damage stimulus', 'DNA repair', 'double-strand break repair via homologous recombination', 'establishment of protein localization to telomere', 'mitotic G2/M transition checkpoint', 'positive regulation of telomere capping', 'response to ionizing radiation']['cellular response to DNA damage stimulus', 'DNA repair', 'double-strand break repair via homologous recombination', 'establishment of protein localization to telomere', 'mitotic G2/M transition checkpoint', 'positive regulation of telomere capping', 'response to ionizing radiation']
Proprotein convertase subtilisin/kexin type 9
378
Low-density lipoprotein receptor
318
7.7
81
0.16
Q8NBP7P01130['apoptotic process', 'cellular response to insulin stimulus', 'cellular response to starvation', 'cholesterol homeostasis', 'cholesterol metabolic process', 'kidney development', 'lipoprotein metabolic process', 'liver development', 'low-density lipoprotein particle receptor catabolic process', 'lysosomal transport', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of low-density lipoprotein particle receptor binding', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of receptor internalization', 'negative regulation of receptor recycling', 'negative regulation of receptor-mediated endocytosis involved in cholesterol transport', 'negative regulation of sodium ion transmembrane transporter activity', 'neurogenesis', 'neuron differentiation', 'phospholipid metabolic process', 'positive regulation of low-density lipoprotein particle receptor catabolic process', 'positive regulation of neuron apoptotic process', 'positive regulation of receptor internalization', 'protein autoprocessing', 'regulation of neuron apoptotic process', 'regulation of signaling receptor activity', 'triglyceride metabolic process']['amyloid-beta clearance', 'amyloid-beta clearance by cellular catabolic process', 'artery morphogenesis', 'cellular response to fatty acid', 'cellular response to low-density lipoprotein particle stimulus', 'cholesterol homeostasis', 'cholesterol import', 'cholesterol metabolic process', 'cholesterol transport', 'endocytosis', 'high-density lipoprotein particle clearance', 'intestinal cholesterol absorption', 'lipid metabolic process', 'lipoprotein catabolic process', 'long-term memory', 'low-density lipoprotein particle clearance', 'negative regulation of amyloid fibril formation', 'negative regulation of astrocyte activation', 'negative regulation of gene expression', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of microglial cell activation', 'negative regulation of protein metabolic process', 'negative regulation of receptor recycling', 'phagocytosis', 'phospholipid transport', 'plasma lipoprotein particle clearance', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of lysosomal protein catabolic process', 'positive regulation of triglyceride biosynthetic process', 'receptor-mediated endocytosis', 'receptor-mediated endocytosis involved in cholesterol transport', 'regulation of cholesterol metabolic process', 'regulation of phosphatidylcholine catabolic process', 'regulation of protein metabolic process', 'response to caloric restriction']
Tumor necrosis factor receptor superfamily member 9
77
Tumor necrosis factor receptor superfamily member 9
31
9.4
81
0.13
P20334P20334['apoptotic process', 'negative regulation of cell population proliferation', 'regulation of cell population proliferation', 'regulation of immature T cell proliferation in thymus']['apoptotic process', 'negative regulation of cell population proliferation', 'regulation of cell population proliferation', 'regulation of immature T cell proliferation in thymus']
Homeobox protein NANOG
109
Homeobox protein NANOG
151
2.0
53
0.93
Q80Z64Q80Z64['BMP signaling pathway', 'cell dedifferentiation', 'cellular response to erythropoietin', 'cellular response to rapamycin', 'embryonic pattern specification', 'endodermal cell fate specification', 'gene expression', 'gonad development', 'mesodermal cell fate commitment', 'multidimensional cell growth', 'negative regulation of BMP signaling pathway', 'negative regulation of cell fate commitment', 'negative regulation of endodermal cell fate specification', 'negative regulation of stem cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of cell population proliferation', 'positive regulation of mitotic cell cycle', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of stem cell division', 'regulation of transcription by RNA polymerase II', 'response to organic substance', 'response to retinoic acid', 'somatic stem cell population maintenance', 'stem cell differentiation', 'stem cell division', 'stem cell population maintenance', 'tissue regeneration']['BMP signaling pathway', 'cell dedifferentiation', 'cellular response to erythropoietin', 'cellular response to rapamycin', 'embryonic pattern specification', 'endodermal cell fate specification', 'gene expression', 'gonad development', 'mesodermal cell fate commitment', 'multidimensional cell growth', 'negative regulation of BMP signaling pathway', 'negative regulation of cell fate commitment', 'negative regulation of endodermal cell fate specification', 'negative regulation of stem cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of cell population proliferation', 'positive regulation of mitotic cell cycle', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of stem cell division', 'regulation of transcription by RNA polymerase II', 'response to organic substance', 'response to retinoic acid', 'somatic stem cell population maintenance', 'stem cell differentiation', 'stem cell division', 'stem cell population maintenance', 'tissue regeneration']
Glial cell line-derived neurotrophic factor
178
Glial cell line-derived neurotrophic factor
149
8.0
63
0.2
Q07731Q07731['branching involved in ureteric bud morphogenesis', 'cell population proliferation', 'cellular response to dexamethasone stimulus', 'commissural neuron axon guidance', 'dorsal spinal cord development', 'embryonic organ development', 'enteric nervous system development', 'male gonad development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'metanephros development', 'midbrain development', 'mRNA stabilization', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of neuron apoptotic process', 'nervous system development', 'neural crest cell migration', 'neuron differentiation', 'neuron projection development', 'organ induction', 'peripheral nervous system development', 'peristalsis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis', 'positive regulation of monooxygenase activity', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of ureteric bud formation', 'postganglionic parasympathetic fiber development', 'postsynaptic membrane organization', 'regulation of dopamine uptake involved in synaptic transmission', 'regulation of gene expression', 'regulation of morphogenesis of a branching structure', 'regulation of semaphorin-plexin signaling pathway', 'regulation of ureteric bud formation', 'response to wounding', 'retina development in camera-type eye', 'sympathetic nervous system development', 'ureteric bud development', 'ureteric bud formation']['branching involved in ureteric bud morphogenesis', 'cell population proliferation', 'cellular response to dexamethasone stimulus', 'commissural neuron axon guidance', 'dorsal spinal cord development', 'embryonic organ development', 'enteric nervous system development', 'male gonad development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'metanephros development', 'midbrain development', 'mRNA stabilization', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of neuron apoptotic process', 'nervous system development', 'neural crest cell migration', 'neuron differentiation', 'neuron projection development', 'organ induction', 'peripheral nervous system development', 'peristalsis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis', 'positive regulation of monooxygenase activity', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of ureteric bud formation', 'postganglionic parasympathetic fiber development', 'postsynaptic membrane organization', 'regulation of dopamine uptake involved in synaptic transmission', 'regulation of gene expression', 'regulation of morphogenesis of a branching structure', 'regulation of semaphorin-plexin signaling pathway', 'regulation of ureteric bud formation', 'response to wounding', 'retina development in camera-type eye', 'sympathetic nervous system development', 'ureteric bud development', 'ureteric bud formation']
Cryptochrome-1
363
Period circadian protein homolog 2
1210
10.0
77
0.13
P97784O54943['circadian regulation of gene expression', 'circadian rhythm', 'DNA damage induced protein phosphorylation', 'entrainment of circadian clock by photoperiod', 'gluconeogenesis', 'glucose homeostasis', 'lipid storage', 'negative regulation of circadian rhythm', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of glucocorticoid receptor signaling pathway', 'negative regulation of glucocorticoid secretion', 'negative regulation of gluconeogenesis', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of protein ubiquitination', 'regulation of circadian rhythm', 'regulation of DNA damage checkpoint', 'response to activity', 'response to glucagon', 'response to insulin', 'response to light stimulus']['circadian regulation of gene expression', 'circadian regulation of translation', 'circadian rhythm', 'entrainment of circadian clock by photoperiod', 'fatty acid metabolic process', 'gluconeogenesis', 'glycogen biosynthetic process', 'histone H3 deacetylation', 'lactate biosynthetic process', 'negative regulation of circadian rhythm', 'negative regulation of DNA-templated transcription, termination', 'negative regulation of fat cell proliferation', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription regulatory region DNA binding', 'negative regulation of transcription, DNA-templated', 'positive regulation of cold-induced thermogenesis', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of glutamate uptake involved in transmission of nerve impulse', 'regulation of insulin secretion', 'regulation of neurogenesis', 'regulation of vasoconstriction', 'response to ischemia', 'white fat cell differentiation']
Hepatocyte growth factor
129
Hepatocyte growth factor
212
9.6
87
0.12
Q08048Q08048['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'proteolysis', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'proteolysis', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']
Protein cereblon
326
Protein cereblon
329
9.4
78
0.14
Q8C7D2Q8C7D2['locomotory exploration behavior', 'negative regulation of ion transmembrane transport', 'negative regulation of large conductance calcium-activated potassium channel activity', 'negative regulation of protein-containing complex assembly', 'positive regulation of protein-containing complex assembly', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination']['locomotory exploration behavior', 'negative regulation of ion transmembrane transport', 'negative regulation of large conductance calcium-activated potassium channel activity', 'negative regulation of protein-containing complex assembly', 'positive regulation of protein-containing complex assembly', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination']
Double C2-like domain-containing protein beta
249
Double C2-like domain-containing protein beta
249
2.0
74
0.66
P70610P70610['calcium ion-regulated exocytosis of neurotransmitter', 'exocytosis', 'positive regulation of calcium ion-dependent exocytosis', 'positive regulation of insulin secretion', 'positive regulation of vesicle fusion', 'protein localization', 'regulation of calcium ion-dependent exocytosis', 'spontaneous neurotransmitter secretion']['calcium ion-regulated exocytosis of neurotransmitter', 'exocytosis', 'positive regulation of calcium ion-dependent exocytosis', 'positive regulation of insulin secretion', 'positive regulation of vesicle fusion', 'protein localization', 'regulation of calcium ion-dependent exocytosis', 'spontaneous neurotransmitter secretion']
Laminin subunit beta-1
1785
Laminin subunit gamma-1
1600
2.0
61
0.81
P07942P11047['animal organ morphogenesis', 'basement membrane assembly', 'cell adhesion', 'cell migration', 'endodermal cell differentiation', 'neuron projection development', 'neuronal-glial interaction involved in cerebral cortex radial glia guided migration', 'odontogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of epithelial cell proliferation', 'positive regulation of integrin-mediated signaling pathway', 'positive regulation of muscle cell differentiation', 'regulation of basement membrane organization', 'substrate adhesion-dependent cell spreading', 'tissue development']['animal organ morphogenesis', 'cell adhesion', 'cell migration', 'endoderm development', 'extracellular matrix disassembly', 'hemidesmosome assembly', 'maintenance of blood-brain barrier', 'positive regulation of cell adhesion', 'positive regulation of epithelial cell proliferation', 'positive regulation of integrin-mediated signaling pathway', 'positive regulation of muscle cell differentiation', 'protein-containing complex assembly', 'regulation of basement membrane organization', 'substrate adhesion-dependent cell spreading', 'tissue development']
Fibrinogen gamma-B chain
33
Fibrinogen gamma-B chain
33
7.8
51
0.25
P12799P12799['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'platelet aggregation', 'protein polymerization']['blood coagulation, fibrin clot formation', 'cell-matrix adhesion', 'platelet aggregation', 'protein polymerization']
Lysosomal alpha-mannosidase
56
Lysosomal alpha-mannosidase
360
2.0
66
0.74
Q29451Q29451['mannose metabolic process', 'protein modification process']['mannose metabolic process', 'protein modification process']
Actin, cytoplasmic 1
374
Actin, cytoplasmic 1
374
2.0
nan
nan
P60712P60712['adherens junction assembly', 'apical protein localization', 'axonogenesis', 'cell motility', 'cellular response to cytochalasin B', 'establishment or maintenance of cell polarity', 'histone H2A acetylation', 'histone H4 acetylation', 'morphogenesis of a polarized epithelium', 'negative regulation of protein binding', 'positive regulation of double-strand break repair via homologous recombination', 'protein localization to adherens junction', 'regulation of cell cycle', 'regulation of norepinephrine uptake', 'regulation of protein localization to plasma membrane', 'regulation of transepithelial transport', 'regulation of transmembrane transporter activity', 'synaptic vesicle endocytosis']['adherens junction assembly', 'apical protein localization', 'axonogenesis', 'cell motility', 'cellular response to cytochalasin B', 'establishment or maintenance of cell polarity', 'histone H2A acetylation', 'histone H4 acetylation', 'morphogenesis of a polarized epithelium', 'negative regulation of protein binding', 'positive regulation of double-strand break repair via homologous recombination', 'protein localization to adherens junction', 'regulation of cell cycle', 'regulation of norepinephrine uptake', 'regulation of protein localization to plasma membrane', 'regulation of transepithelial transport', 'regulation of transmembrane transporter activity', 'synaptic vesicle endocytosis']
Protein disulfide-isomerase A3
57
Tapasin
115
2.0
67
0.73
P30101O15533['cellular response to interleukin-7', 'extrinsic apoptotic signaling pathway', 'peptide antigen assembly with MHC class I protein complex', 'positive regulation of extrinsic apoptotic signaling pathway', 'protein folding', 'protein folding in endoplasmic reticulum', 'response to endoplasmic reticulum stress']['antigen processing and presentation of endogenous peptide antigen via MHC class I', 'immune response', 'MHC class I protein complex assembly', 'MHC class Ib protein complex assembly', 'peptide antigen assembly with MHC class I protein complex', 'peptide antigen stabilization', 'protein-containing complex assembly', 'regulation of gene expression', 'regulation of immune response', 'regulation of protein complex stability', 'retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum']
Repulsive guidance molecule B
163
Repulsive guidance molecule B
312
2.0
81
0.61
Q6NW40Q6NW40['BMP signaling pathway', 'cell adhesion', 'positive regulation of transcription, DNA-templated', 'signal transduction']['BMP signaling pathway', 'cell adhesion', 'positive regulation of transcription, DNA-templated', 'signal transduction']
Serine protease 1
132
Serine protease 1
233
8.2
77
0.16
P00760P00760['digestion', 'proteolysis']['digestion', 'proteolysis']
Vitamin K-dependent protein C
319
Vitamin K-dependent protein C
183
2.0
81
0.6
P04070P04070['blood coagulation', 'negative regulation of apoptotic process', 'negative regulation of blood coagulation', 'negative regulation of coagulation', 'negative regulation of inflammatory response', 'positive regulation of establishment of endothelial barrier', 'proteolysis']['blood coagulation', 'negative regulation of apoptotic process', 'negative regulation of blood coagulation', 'negative regulation of coagulation', 'negative regulation of inflammatory response', 'positive regulation of establishment of endothelial barrier', 'proteolysis']
Artemin
187
Artemin
218
9.6
66
0.16
Q5T4W7Q5T4W7['axon guidance', 'induction of positive chemotaxis', 'lymphocyte migration into lymphoid organs', 'neuroblast proliferation', 'peripheral nervous system development', "Peyer's patch morphogenesis", 'signal transduction']['axon guidance', 'induction of positive chemotaxis', 'lymphocyte migration into lymphoid organs', 'neuroblast proliferation', 'peripheral nervous system development', "Peyer's patch morphogenesis", 'signal transduction']
Proprotein convertase subtilisin/kexin type 9
378
Low-density lipoprotein receptor
338
9.5
78
0.14
Q8NBP7P01130['apoptotic process', 'cellular response to insulin stimulus', 'cellular response to starvation', 'cholesterol homeostasis', 'cholesterol metabolic process', 'kidney development', 'lipoprotein metabolic process', 'liver development', 'low-density lipoprotein particle receptor catabolic process', 'lysosomal transport', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of low-density lipoprotein particle receptor binding', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of receptor internalization', 'negative regulation of receptor recycling', 'negative regulation of receptor-mediated endocytosis involved in cholesterol transport', 'negative regulation of sodium ion transmembrane transporter activity', 'neurogenesis', 'neuron differentiation', 'phospholipid metabolic process', 'positive regulation of low-density lipoprotein particle receptor catabolic process', 'positive regulation of neuron apoptotic process', 'positive regulation of receptor internalization', 'protein autoprocessing', 'regulation of neuron apoptotic process', 'regulation of signaling receptor activity', 'triglyceride metabolic process']['amyloid-beta clearance', 'amyloid-beta clearance by cellular catabolic process', 'artery morphogenesis', 'cellular response to fatty acid', 'cellular response to low-density lipoprotein particle stimulus', 'cholesterol homeostasis', 'cholesterol import', 'cholesterol metabolic process', 'cholesterol transport', 'endocytosis', 'high-density lipoprotein particle clearance', 'intestinal cholesterol absorption', 'lipid metabolic process', 'lipoprotein catabolic process', 'long-term memory', 'low-density lipoprotein particle clearance', 'negative regulation of amyloid fibril formation', 'negative regulation of astrocyte activation', 'negative regulation of gene expression', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of microglial cell activation', 'negative regulation of protein metabolic process', 'negative regulation of receptor recycling', 'phagocytosis', 'phospholipid transport', 'plasma lipoprotein particle clearance', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of lysosomal protein catabolic process', 'positive regulation of triglyceride biosynthetic process', 'receptor-mediated endocytosis', 'receptor-mediated endocytosis involved in cholesterol transport', 'regulation of cholesterol metabolic process', 'regulation of phosphatidylcholine catabolic process', 'regulation of protein metabolic process', 'response to caloric restriction']
cAMP-dependent protein kinase type I-alpha regulatory subunit
17
cAMP-dependent protein kinase type I-alpha regulatory subunit
38
2.0
64
0.78
1
✔P00514P00514['cardiac muscle cell proliferation', 'mesoderm formation', 'negative regulation of activated T cell proliferation', 'negative regulation of cAMP-dependent protein kinase activity', 'negative regulation of gene expression', 'sarcomere organization']['cardiac muscle cell proliferation', 'mesoderm formation', 'negative regulation of activated T cell proliferation', 'negative regulation of cAMP-dependent protein kinase activity', 'negative regulation of gene expression', 'sarcomere organization']
Cryptochrome-2
381
Period circadian protein homolog 2
1210
9.1
76
0.14
Q9R194O54943['circadian regulation of gene expression', 'circadian rhythm', 'entrainment of circadian clock by photoperiod', 'glucose homeostasis', 'lipid storage', 'negative regulation of circadian rhythm', 'negative regulation of glucocorticoid receptor signaling pathway', 'negative regulation of glucocorticoid secretion', 'negative regulation of phosphoprotein phosphatase activity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'protein import into nucleus', 'regulation of circadian rhythm', 'regulation of sodium-dependent phosphate transport', 'response to activity', 'response to insulin', 'response to light stimulus']['circadian regulation of gene expression', 'circadian regulation of translation', 'circadian rhythm', 'entrainment of circadian clock by photoperiod', 'fatty acid metabolic process', 'gluconeogenesis', 'glycogen biosynthetic process', 'histone H3 deacetylation', 'lactate biosynthetic process', 'negative regulation of circadian rhythm', 'negative regulation of DNA-templated transcription, termination', 'negative regulation of fat cell proliferation', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription regulatory region DNA binding', 'negative regulation of transcription, DNA-templated', 'positive regulation of cold-induced thermogenesis', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of glutamate uptake involved in transmission of nerve impulse', 'regulation of insulin secretion', 'regulation of neurogenesis', 'regulation of vasoconstriction', 'response to ischemia', 'white fat cell differentiation']
D(3) dopamine receptor
122
D(3) dopamine receptor
166
6.1
92
0.18
P35462P35462['acid secretion', 'adenylate cyclase-activating adrenergic receptor signaling pathway', 'adenylate cyclase-activating dopamine receptor signaling pathway', 'adenylate cyclase-inhibiting dopamine receptor signaling pathway', 'arachidonic acid secretion', 'autophagy', 'behavioral response to cocaine', 'cellular calcium ion homeostasis', 'circadian regulation of gene expression', 'dopamine metabolic process', 'G protein-coupled receptor internalization', 'G protein-coupled receptor signaling pathway', 'gastric emptying', 'learning', 'learning or memory', 'locomotory behavior', 'musculoskeletal movement, spinal reflex action', 'negative regulation of adenylate cyclase activity', 'negative regulation of apoptotic process', 'negative regulation of blood pressure', 'negative regulation of cytosolic calcium ion concentration', 'negative regulation of oligodendrocyte differentiation', 'negative regulation of protein kinase B signaling', 'negative regulation of protein secretion', 'negative regulation of sodium', 'negative regulation of synaptic transmission, glutamatergic', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of voltage-gated calcium channel activity', 'phospholipase C-activating dopamine receptor signaling pathway', 'positive regulation of cell population proliferation', 'positive regulation of cytokinesis', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of dopamine receptor signaling pathway', 'positive regulation of mitotic nuclear division', 'positive regulation of renal sodium excretion', 'positive regulation of transcription by RNA polymerase II', 'prepulse inhibition', 'regulation of circadian sleep/wake cycle, sleep', 'regulation of dopamine secretion', 'regulation of dopamine uptake involved in synaptic transmission', 'regulation of locomotion involved in locomotory behavior', 'regulation of postsynaptic neurotransmitter receptor internalization', 'regulation of potassium ion transport', 'response to cocaine', 'response to histamine', 'response to morphine', 'response to xenobiotic stimulus', 'social behavior', 'visual learning']['acid secretion', 'adenylate cyclase-activating adrenergic receptor signaling pathway', 'adenylate cyclase-activating dopamine receptor signaling pathway', 'adenylate cyclase-inhibiting dopamine receptor signaling pathway', 'arachidonic acid secretion', 'autophagy', 'behavioral response to cocaine', 'cellular calcium ion homeostasis', 'circadian regulation of gene expression', 'dopamine metabolic process', 'G protein-coupled receptor internalization', 'G protein-coupled receptor signaling pathway', 'gastric emptying', 'learning', 'learning or memory', 'locomotory behavior', 'musculoskeletal movement, spinal reflex action', 'negative regulation of adenylate cyclase activity', 'negative regulation of apoptotic process', 'negative regulation of blood pressure', 'negative regulation of cytosolic calcium ion concentration', 'negative regulation of oligodendrocyte differentiation', 'negative regulation of protein kinase B signaling', 'negative regulation of protein secretion', 'negative regulation of sodium', 'negative regulation of synaptic transmission, glutamatergic', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of voltage-gated calcium channel activity', 'phospholipase C-activating dopamine receptor signaling pathway', 'positive regulation of cell population proliferation', 'positive regulation of cytokinesis', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of dopamine receptor signaling pathway', 'positive regulation of mitotic nuclear division', 'positive regulation of renal sodium excretion', 'positive regulation of transcription by RNA polymerase II', 'prepulse inhibition', 'regulation of circadian sleep/wake cycle, sleep', 'regulation of dopamine secretion', 'regulation of dopamine uptake involved in synaptic transmission', 'regulation of locomotion involved in locomotory behavior', 'regulation of postsynaptic neurotransmitter receptor internalization', 'regulation of potassium ion transport', 'response to cocaine', 'response to histamine', 'response to morphine', 'response to xenobiotic stimulus', 'social behavior', 'visual learning']
Chitotriosidase-1
440
Chitotriosidase-1
462
8.7
79
0.15
Q13231Q13231['chitin catabolic process', 'immune response', 'polysaccharide catabolic process', 'polysaccharide digestion', 'response to bacterium']['chitin catabolic process', 'immune response', 'polysaccharide catabolic process', 'polysaccharide digestion', 'response to bacterium']
Acid ceramidase
31
Acid ceramidase
340
2.0
64
0.77
Q13510Q13510['cellular response to tumor necrosis factor', 'ceramide biosynthetic process', 'ceramide catabolic process', 'fatty acid metabolic process', 'keratinocyte differentiation', 'negative regulation of nucleic acid-templated transcription', 'regulation of programmed necrotic cell death', 'regulation of steroid biosynthetic process', 'sphingosine biosynthetic process']['cellular response to tumor necrosis factor', 'ceramide biosynthetic process', 'ceramide catabolic process', 'fatty acid metabolic process', 'keratinocyte differentiation', 'negative regulation of nucleic acid-templated transcription', 'regulation of programmed necrotic cell death', 'regulation of steroid biosynthetic process', 'sphingosine biosynthetic process']
Proprotein convertase subtilisin/kexin type 9
375
Low-density lipoprotein receptor
318
8.7
65
0.18
Q8NBP7P01130['apoptotic process', 'cellular response to insulin stimulus', 'cellular response to starvation', 'cholesterol homeostasis', 'cholesterol metabolic process', 'kidney development', 'lipoprotein metabolic process', 'liver development', 'low-density lipoprotein particle receptor catabolic process', 'lysosomal transport', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of low-density lipoprotein particle receptor binding', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of receptor internalization', 'negative regulation of receptor recycling', 'negative regulation of receptor-mediated endocytosis involved in cholesterol transport', 'negative regulation of sodium ion transmembrane transporter activity', 'neurogenesis', 'neuron differentiation', 'phospholipid metabolic process', 'positive regulation of low-density lipoprotein particle receptor catabolic process', 'positive regulation of neuron apoptotic process', 'positive regulation of receptor internalization', 'protein autoprocessing', 'regulation of neuron apoptotic process', 'regulation of signaling receptor activity', 'triglyceride metabolic process']['amyloid-beta clearance', 'amyloid-beta clearance by cellular catabolic process', 'artery morphogenesis', 'cellular response to fatty acid', 'cellular response to low-density lipoprotein particle stimulus', 'cholesterol homeostasis', 'cholesterol import', 'cholesterol metabolic process', 'cholesterol transport', 'endocytosis', 'high-density lipoprotein particle clearance', 'intestinal cholesterol absorption', 'lipid metabolic process', 'lipoprotein catabolic process', 'long-term memory', 'low-density lipoprotein particle clearance', 'negative regulation of amyloid fibril formation', 'negative regulation of astrocyte activation', 'negative regulation of gene expression', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of microglial cell activation', 'negative regulation of protein metabolic process', 'negative regulation of receptor recycling', 'phagocytosis', 'phospholipid transport', 'plasma lipoprotein particle clearance', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of lysosomal protein catabolic process', 'positive regulation of triglyceride biosynthetic process', 'receptor-mediated endocytosis', 'receptor-mediated endocytosis involved in cholesterol transport', 'regulation of cholesterol metabolic process', 'regulation of phosphatidylcholine catabolic process', 'regulation of protein metabolic process', 'response to caloric restriction']
Lamin-B1
317
Lamin-B1
317
2.1
44
1.1
P20700P20700['heterochromatin assembly', 'nuclear envelope organization', 'nuclear migration', 'nuclear pore localization', 'protein localization to nuclear envelope']['heterochromatin assembly', 'nuclear envelope organization', 'nuclear migration', 'nuclear pore localization', 'protein localization to nuclear envelope']
Complement C5
731
Complement C5
699
9.4
79
0.13
P01031P01031['cell surface receptor signaling pathway', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'G protein-coupled receptor signaling pathway', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']['cell surface receptor signaling pathway', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'G protein-coupled receptor signaling pathway', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']
Regulator of nonsense transcripts 1
237
Regulator of nonsense transcripts 1
237
8.2
72
0.17
Q92900Q92900["3'-UTR-mediated mRNA destabilization", 'cell cycle phase transition', 'cellular response to interleukin-1', 'cellular response to lipopolysaccharide', 'DNA duplex unwinding', 'DNA repair', 'DNA replication', 'histone mRNA catabolic process', 'mRNA export from nucleus', 'nuclear-transcribed mRNA catabolic process', 'nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay', 'nuclear-transcribed mRNA catabolic process, nonsense-mediated decay', 'positive regulation of mRNA catabolic process', 'regulation of telomere maintenance', 'regulation of translational termination', 'telomere maintenance via semi-conservative replication']["3'-UTR-mediated mRNA destabilization", 'cell cycle phase transition', 'cellular response to interleukin-1', 'cellular response to lipopolysaccharide', 'DNA duplex unwinding', 'DNA repair', 'DNA replication', 'histone mRNA catabolic process', 'mRNA export from nucleus', 'nuclear-transcribed mRNA catabolic process', 'nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay', 'nuclear-transcribed mRNA catabolic process, nonsense-mediated decay', 'positive regulation of mRNA catabolic process', 'regulation of telomere maintenance', 'regulation of translational termination', 'telomere maintenance via semi-conservative replication']
C-C motif chemokine 2
34
C-C motif chemokine 2
59
8.2
63
0.19
P13500P13500['angiogenesis', 'animal organ morphogenesis', 'astrocyte cell migration', 'cell adhesion', 'cell surface receptor signaling pathway', 'cellular homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to lipopolysaccharide', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'cytoskeleton organization', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'helper T cell extravasation', 'humoral immune response', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of glial cell apoptotic process', 'negative regulation of natural killer cell chemotaxis', 'negative regulation of neuron apoptotic process', 'negative regulation of vascular endothelial cell proliferation', 'neutrophil chemotaxis', 'positive regulation of apoptotic cell clearance', 'positive regulation of calcium ion import', 'positive regulation of endothelial cell apoptotic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of nitric-oxide synthase biosynthetic process', 'positive regulation of NMDA glutamate receptor activity', 'positive regulation of synaptic transmission, glutamatergic', 'positive regulation of T cell activation', 'protein kinase B signaling', 'protein phosphorylation', 'receptor signaling pathway via JAK-STAT', 'regulation of cell shape', 'response to bacterium', 'sensory perception of pain', 'signal transduction', 'viral genome replication']['angiogenesis', 'animal organ morphogenesis', 'astrocyte cell migration', 'cell adhesion', 'cell surface receptor signaling pathway', 'cellular homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to lipopolysaccharide', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'cytoskeleton organization', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'helper T cell extravasation', 'humoral immune response', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of glial cell apoptotic process', 'negative regulation of natural killer cell chemotaxis', 'negative regulation of neuron apoptotic process', 'negative regulation of vascular endothelial cell proliferation', 'neutrophil chemotaxis', 'positive regulation of apoptotic cell clearance', 'positive regulation of calcium ion import', 'positive regulation of endothelial cell apoptotic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of nitric-oxide synthase biosynthetic process', 'positive regulation of NMDA glutamate receptor activity', 'positive regulation of synaptic transmission, glutamatergic', 'positive regulation of T cell activation', 'protein kinase B signaling', 'protein phosphorylation', 'receptor signaling pathway via JAK-STAT', 'regulation of cell shape', 'response to bacterium', 'sensory perception of pain', 'signal transduction', 'viral genome replication']
Sequestosome-1
131
Sequestosome-1
151
8.7
70
0.16
Q13501Q13501['aggrephagy', 'apoptotic process', 'autophagy', 'autophagy of mitochondrion', 'brown fat cell proliferation', 'cell differentiation', 'endosomal transport', 'endosome organization', 'energy homeostasis', 'immune system process', 'intracellular signal transduction', 'macroautophagy', 'mitophagy', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of apoptotic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'protein import into nucleus', 'protein localization', 'protein localization to perinuclear region of cytoplasm', 'protein phosphorylation', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of mitochondrion organization', 'regulation of protein complex stability', 'regulation of Ras protein signal transduction', 'response to ischemia', 'response to mitochondrial depolarisation', 'selective autophagy', 'temperature homeostasis', 'transcription by RNA polymerase II', 'ubiquitin-dependent protein catabolic process']['aggrephagy', 'apoptotic process', 'autophagy', 'autophagy of mitochondrion', 'brown fat cell proliferation', 'cell differentiation', 'endosomal transport', 'endosome organization', 'energy homeostasis', 'immune system process', 'intracellular signal transduction', 'macroautophagy', 'mitophagy', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of apoptotic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'protein import into nucleus', 'protein localization', 'protein localization to perinuclear region of cytoplasm', 'protein phosphorylation', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of mitochondrion organization', 'regulation of protein complex stability', 'regulation of Ras protein signal transduction', 'response to ischemia', 'response to mitochondrial depolarisation', 'selective autophagy', 'temperature homeostasis', 'transcription by RNA polymerase II', 'ubiquitin-dependent protein catabolic process']
Ribonuclease pancreatic
100
Ribonuclease inhibitor
409
10.0
69
0.15
P07998P13489['defense response to Gram-positive bacterium', 'RNA phosphodiester bond hydrolysis']['mRNA catabolic process', 'regulation of angiogenesis']
MORC family CW-type zinc finger protein 3
413
MORC family CW-type zinc finger protein 3
413
8.7
75
0.15
Q14149Q14149['innate immune response', 'maintenance of protein location in nucleus', 'negative regulation of fibroblast proliferation', 'peptidyl-serine phosphorylation', 'positive regulation of cellular senescence', 'post-embryonic development', 'protein phosphorylation', 'protein stabilization']['innate immune response', 'maintenance of protein location in nucleus', 'negative regulation of fibroblast proliferation', 'peptidyl-serine phosphorylation', 'positive regulation of cellular senescence', 'post-embryonic development', 'protein phosphorylation', 'protein stabilization']
A disintegrin and metalloproteinase with thrombospondin motifs 5
376
A disintegrin and metalloproteinase with thrombospondin motifs 5
394
8.7
74
0.15
Q9UNA0Q9UNA0['defense response to bacterium', 'extracellular matrix disassembly', 'extracellular matrix organization', 'myoblast fusion', 'negative regulation of cold-induced thermogenesis', 'proteolysis', 'tooth eruption']['defense response to bacterium', 'extracellular matrix disassembly', 'extracellular matrix organization', 'myoblast fusion', 'negative regulation of cold-induced thermogenesis', 'proteolysis', 'tooth eruption']
Peroxiredoxin-5, mitochondrial
100
Peroxiredoxin-5, mitochondrial
100
8.7
71
0.16
P30044P30044['cell redox homeostasis', 'cellular response to oxidative stress', 'cellular response to reactive oxygen species', 'hydrogen peroxide catabolic process', 'inflammatory response', 'NADPH oxidation', 'negative regulation of apoptotic process', 'negative regulation of oxidoreductase activity', 'negative regulation of transcription by RNA polymerase III', 'positive regulation of collagen biosynthetic process', 'reactive nitrogen species metabolic process', 'regulation of apoptosis involved in tissue homeostasis', 'response to oxidative stress']['cell redox homeostasis', 'cellular response to oxidative stress', 'cellular response to reactive oxygen species', 'hydrogen peroxide catabolic process', 'inflammatory response', 'NADPH oxidation', 'negative regulation of apoptotic process', 'negative regulation of oxidoreductase activity', 'negative regulation of transcription by RNA polymerase III', 'positive regulation of collagen biosynthetic process', 'reactive nitrogen species metabolic process', 'regulation of apoptosis involved in tissue homeostasis', 'response to oxidative stress']
Protein fem-1 homolog C
205
Protein fem-1 homolog C
205
9.9
52
0.2
Q96JP0Q96JP0['proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination', 'ubiquitin-dependent protein catabolic process', 'ubiquitin-dependent protein catabolic process via the C-end degron rule pathway']['proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination', 'ubiquitin-dependent protein catabolic process', 'ubiquitin-dependent protein catabolic process via the C-end degron rule pathway']
S-adenosylmethionine synthase isoform type-1
60
S-adenosylmethionine synthase isoform type-1
68
8.2
86
0.14
Q00266Q00266['methionine catabolic process', 'one-carbon metabolic process', 'protein homotetramerization', 'S-adenosylmethionine biosynthetic process']['methionine catabolic process', 'one-carbon metabolic process', 'protein homotetramerization', 'S-adenosylmethionine biosynthetic process']
Protein S100-A3
23
Protein S100-A3
14
10.0
72
0.14
P33764P33764[][]
Interleukin-6 receptor subunit alpha
121
Interleukin-6 receptor subunit alpha
176
7.9
72
0.18
P08887P08887['acute-phase response', 'ciliary neurotrophic factor-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'endocrine pancreas development', 'extrinsic apoptotic signaling pathway', 'hepatic immune response', 'interleukin-6-mediated signaling pathway', 'monocyte chemotaxis', 'negative regulation of collagen biosynthetic process', 'negative regulation of interleukin-8 production', 'neutrophil mediated immunity', 'positive regulation of activation of Janus kinase activity', 'positive regulation of cell population proliferation', 'positive regulation of chemokine production', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of interleukin-6 production', 'positive regulation of leukocyte chemotaxis', 'positive regulation of MAPK cascade', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of platelet aggregation', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'response to cytokine', 'T-helper 17 cell lineage commitment', 'vascular endothelial growth factor production']['acute-phase response', 'ciliary neurotrophic factor-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'endocrine pancreas development', 'extrinsic apoptotic signaling pathway', 'hepatic immune response', 'interleukin-6-mediated signaling pathway', 'monocyte chemotaxis', 'negative regulation of collagen biosynthetic process', 'negative regulation of interleukin-8 production', 'neutrophil mediated immunity', 'positive regulation of activation of Janus kinase activity', 'positive regulation of cell population proliferation', 'positive regulation of chemokine production', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of interleukin-6 production', 'positive regulation of leukocyte chemotaxis', 'positive regulation of MAPK cascade', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of platelet aggregation', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'response to cytokine', 'T-helper 17 cell lineage commitment', 'vascular endothelial growth factor production']
General transcription factor IIH subunit 3
142
General transcription factor IIH subunit 2
382
9.5
88
0.12
Q13889Q13888['DNA repair', 'nucleotide-excision repair', 'phosphorylation of RNA polymerase II C-terminal domain', 'transcription by RNA polymerase II']['G protein-coupled receptor internalization', 'nucleotide-excision repair', 'positive regulation of DNA helicase activity', 'regulation of transcription by RNA polymerase II', 'response to UV', 'transcription by RNA polymerase II', 'transcription initiation from RNA polymerase II promoter']
Thioredoxin
73
Thioredoxin
73
2.0
74
0.67
P10599P10599['activation of protein kinase B activity', 'cell redox homeostasis', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of protein export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA binding', 'positive regulation of peptidyl-cysteine S-nitrosylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'response to nitric oxide', 'response to radiation']['activation of protein kinase B activity', 'cell redox homeostasis', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of protein export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA binding', 'positive regulation of peptidyl-cysteine S-nitrosylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'response to nitric oxide', 'response to radiation']
Interleukin-17A
146
Interleukin-17F
154
7.9
96
0.13
Q16552Q96PD4['adaptive immune response', 'apoptotic process', 'cell death', 'cell-cell signaling', 'cellular response to interleukin-1', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'fibroblast activation', 'granulocyte migration', 'immune response', 'inflammatory response', 'innate immune response', 'interleukin-17-mediated signaling pathway', 'intestinal epithelial structure maintenance', 'Notch signaling pathway', 'positive regulation of antimicrobial peptide production', 'positive regulation of bicellular tight junction assembly', 'positive regulation of chemokine (C-X-C motif) ligand 1 production', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-16 production', 'positive regulation of interleukin-23 production', 'positive regulation of interleukin-6 production', 'positive regulation of osteoclast differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production']['adaptive immune response', 'cartilage development', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'inflammatory response', 'innate immune response', 'interleukin-17-mediated signaling pathway', 'negative regulation of angiogenesis', 'positive regulation of antimicrobial peptide production', 'positive regulation of chemokine (C-X-C motif) ligand 1 production', 'positive regulation of cytokine production', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of interleukin-6 production', 'positive regulation of lymphotoxin A production', 'positive regulation of transcription by RNA polymerase II', 'regulation of granulocyte macrophage colony-stimulating factor production', 'regulation of interleukin-2 production', 'regulation of interleukin-6 production', 'regulation of interleukin-8 production', 'regulation of transforming growth factor beta receptor signaling pathway']
Pancreatic trypsin inhibitor
40
Pancreatic trypsin inhibitor
65
8.1
62
0.2
P00974P00974['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
Serine/threonine-protein kinase Nek1
163
Serine/threonine-protein kinase Nek1
276
2.1
76
0.63
Q96PY6Q96PY6['cell cycle', 'cell division', 'cilium assembly', 'protein phosphorylation']['cell cycle', 'cell division', 'cilium assembly', 'protein phosphorylation']
Insulin-like growth factor I
54
Insulin-like growth factor-binding protein 1
206
4.5
85
0.26
P05019P08833['activation of protein kinase B activity', 'bone mineralization involved in bone maturation', 'cell activation', 'cell population proliferation', 'cellular response to amyloid-beta', 'ERK1 and ERK2 cascade', 'glycolate metabolic process', 'insulin-like growth factor receptor signaling pathway', 'muscle hypertrophy', 'muscle organ development', 'myoblast differentiation', 'myoblast proliferation', 'myotube cell development', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of gene expression', 'negative regulation of interleukin-1 beta production', 'negative regulation of neuroinflammatory response', 'negative regulation of oocyte development', 'negative regulation of release of cytochrome c from mitochondria', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of tumor necrosis factor production', 'negative regulation of vascular associated smooth muscle cell apoptotic process', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol-mediated signaling', 'positive regulation of activated T cell proliferation', 'positive regulation of calcineurin-NFAT signaling cascade', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of DNA binding', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Ras protein signal transduction', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of trophectodermal cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase B signaling', 'protein stabilization', 'proteoglycan biosynthetic process', 'Ras protein signal transduction', 'regulation of gene expression', 'regulation of multicellular organism growth', 'regulation of protein phosphorylation', 'response to heat', 'signal transduction', 'skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration', 'skeletal system development', 'wound healing']['aging', 'insulin receptor signaling pathway', 'negative regulation of canonical Wnt signaling pathway', 'positive regulation of cell growth', 'regulation of insulin-like growth factor receptor signaling pathway', 'signal transduction', 'tissue regeneration']
Cryptochrome-1
412
Period circadian protein homolog 2
1210
7.2
78
0.18
P97784O54943['circadian regulation of gene expression', 'circadian rhythm', 'DNA damage induced protein phosphorylation', 'entrainment of circadian clock by photoperiod', 'gluconeogenesis', 'glucose homeostasis', 'lipid storage', 'negative regulation of circadian rhythm', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of glucocorticoid receptor signaling pathway', 'negative regulation of glucocorticoid secretion', 'negative regulation of gluconeogenesis', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of protein ubiquitination', 'regulation of circadian rhythm', 'regulation of DNA damage checkpoint', 'response to activity', 'response to glucagon', 'response to insulin', 'response to light stimulus']['circadian regulation of gene expression', 'circadian regulation of translation', 'circadian rhythm', 'entrainment of circadian clock by photoperiod', 'fatty acid metabolic process', 'gluconeogenesis', 'glycogen biosynthetic process', 'histone H3 deacetylation', 'lactate biosynthetic process', 'negative regulation of circadian rhythm', 'negative regulation of DNA-templated transcription, termination', 'negative regulation of fat cell proliferation', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription regulatory region DNA binding', 'negative regulation of transcription, DNA-templated', 'positive regulation of cold-induced thermogenesis', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of glutamate uptake involved in transmission of nerve impulse', 'regulation of insulin secretion', 'regulation of neurogenesis', 'regulation of vasoconstriction', 'response to ischemia', 'white fat cell differentiation']
Hepcidin
73
Neutrophil gelatinase-associated lipocalin
195
5.4
79
0.23
P81172P80188['acute-phase response', 'aging', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular iron ion homeostasis', 'cellular response to bile acid', 'cellular response to interleukin-6', 'cellular response to lipopolysaccharide', 'cellular response to tumor necrosis factor', 'cellular response to X-ray', 'defense response to bacterium', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'establishment of localization in cell', 'immune response', 'iron ion transmembrane transport', 'killing of cells of another organism', 'liver regeneration', 'macrophage activation', 'multicellular organismal iron ion homeostasis', 'myeloid cell homeostasis', 'negative regulation of bone resorption', 'negative regulation of inflammatory response', 'negative regulation of intestinal absorption', 'negative regulation of ion transmembrane transporter activity', 'negative regulation of iron export across plasma membrane', 'negative regulation of iron ion transmembrane transport', 'negative regulation of iron ion transmembrane transporter activity', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of macrophage activation', 'positive regulation of protein catabolic process', 'positive regulation of protein polyubiquitination', 'positive regulation of receptor catabolic process', 'positive regulation of receptor internalization', 'positive regulation of transcription by RNA polymerase II', 'protein catabolic process', 'receptor signaling pathway via JAK-STAT', 'response to erythropoietin', 'response to ethanol', 'response to iron ion', 'response to iron ion starvation', 'response to vitamin A', 'response to zinc ion', 'transcription by RNA polymerase II']['apoptotic process', 'defense response to bacterium', 'innate immune response', 'positive regulation of cold-induced thermogenesis', 'sequestering of iron ion', 'siderophore transport']
DNA helicase MCM8
351
DNA helicase MCM8
351
2.0
54
0.91
Q9UJA3Q9UJA3['cell cycle', 'cellular response to DNA damage stimulus', 'DNA duplex unwinding', 'double-strand break repair via homologous recombination', 'female gamete generation', 'male gamete generation', 'mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication', 'protein localization to chromatin', 'protein stabilization', 'recombinational interstrand cross-link repair']['cell cycle', 'cellular response to DNA damage stimulus', 'DNA duplex unwinding', 'double-strand break repair via homologous recombination', 'female gamete generation', 'male gamete generation', 'mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication', 'protein localization to chromatin', 'protein stabilization', 'recombinational interstrand cross-link repair']
Interleukin-4
151
Interleukin-13 receptor subunit alpha-1
320
8.8
51
0.22
P05112P78552['activation of Janus kinase activity', 'B cell costimulation', 'B cell differentiation', 'cholesterol metabolic process', 'dendritic cell differentiation', 'extrinsic apoptotic signaling pathway in absence of ligand', 'immune response', 'innate immune response in mucosa', 'macrophage activation', 'microglial cell activation', 'myeloid dendritic cell differentiation', 'negative regulation of acute inflammatory response', 'negative regulation of apoptotic process', 'negative regulation of cellular response to transforming growth factor beta stimulus', 'negative regulation of chronic inflammatory response', 'negative regulation of complement-dependent cytotoxicity', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of epithelial cell migration', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of inflammatory response', 'negative regulation of macrophage activation', 'negative regulation of neuroinflammatory response', 'negative regulation of osteoclast differentiation', 'negative regulation of T-helper 17 cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of tumor necrosis factor production', 'neuroinflammatory response', 'positive regulation of amyloid-beta clearance', 'positive regulation of ATP biosynthetic process', 'positive regulation of B cell proliferation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cellular respiration', 'positive regulation of cold-induced thermogenesis', 'positive regulation of defense response to virus by host', 'positive regulation of eosinophil chemotaxis', 'positive regulation of gene expression', 'positive regulation of interleukin-10 production', 'positive regulation of interleukin-13 production', 'positive regulation of isotype switching to IgE isotypes', 'positive regulation of isotype switching to IgG isotypes', 'positive regulation of macroautophagy', 'positive regulation of mast cell degranulation', 'positive regulation of MHC class II biosynthetic process', 'positive regulation of mononuclear cell migration', 'positive regulation of myoblast fusion', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of T cell differentiation', 'positive regulation of T cell proliferation', 'positive regulation of T-helper 2 cell cytokine production', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of tyrosine phosphorylation of STAT protein', 'regulation of immune response', 'regulation of isotype switching', 'regulation of phosphorylation', 'T cell activation', 'T-helper 2 cell differentiation', 'type 2 immune response']['cell surface receptor signaling pathway', 'cytokine-mediated signaling pathway', 'oncostatin-M-mediated signaling pathway', 'positive regulation of cell population proliferation']
Proprotein convertase subtilisin/kexin type 9
378
Low-density lipoprotein receptor
340
9.8
74
0.14
Q8NBP7P01130['apoptotic process', 'cellular response to insulin stimulus', 'cellular response to starvation', 'cholesterol homeostasis', 'cholesterol metabolic process', 'kidney development', 'lipoprotein metabolic process', 'liver development', 'low-density lipoprotein particle receptor catabolic process', 'lysosomal transport', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of low-density lipoprotein particle receptor binding', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of receptor internalization', 'negative regulation of receptor recycling', 'negative regulation of receptor-mediated endocytosis involved in cholesterol transport', 'negative regulation of sodium ion transmembrane transporter activity', 'neurogenesis', 'neuron differentiation', 'phospholipid metabolic process', 'positive regulation of low-density lipoprotein particle receptor catabolic process', 'positive regulation of neuron apoptotic process', 'positive regulation of receptor internalization', 'protein autoprocessing', 'regulation of neuron apoptotic process', 'regulation of signaling receptor activity', 'triglyceride metabolic process']['amyloid-beta clearance', 'amyloid-beta clearance by cellular catabolic process', 'artery morphogenesis', 'cellular response to fatty acid', 'cellular response to low-density lipoprotein particle stimulus', 'cholesterol homeostasis', 'cholesterol import', 'cholesterol metabolic process', 'cholesterol transport', 'endocytosis', 'high-density lipoprotein particle clearance', 'intestinal cholesterol absorption', 'lipid metabolic process', 'lipoprotein catabolic process', 'long-term memory', 'low-density lipoprotein particle clearance', 'negative regulation of amyloid fibril formation', 'negative regulation of astrocyte activation', 'negative regulation of gene expression', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of microglial cell activation', 'negative regulation of protein metabolic process', 'negative regulation of receptor recycling', 'phagocytosis', 'phospholipid transport', 'plasma lipoprotein particle clearance', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of lysosomal protein catabolic process', 'positive regulation of triglyceride biosynthetic process', 'receptor-mediated endocytosis', 'receptor-mediated endocytosis involved in cholesterol transport', 'regulation of cholesterol metabolic process', 'regulation of phosphatidylcholine catabolic process', 'regulation of protein metabolic process', 'response to caloric restriction']
Tumor necrosis factor receptor superfamily member 9
64
Tumor necrosis factor receptor superfamily member 9
31
8.8
68
0.17
P20334P20334['apoptotic process', 'negative regulation of cell population proliferation', 'regulation of cell population proliferation', 'regulation of immature T cell proliferation in thymus']['apoptotic process', 'negative regulation of cell population proliferation', 'regulation of cell population proliferation', 'regulation of immature T cell proliferation in thymus']
Interleukin-4
151
Interleukin-13 receptor subunit alpha-1
257
9.1
50
0.22
P05112P78552['activation of Janus kinase activity', 'B cell costimulation', 'B cell differentiation', 'cholesterol metabolic process', 'dendritic cell differentiation', 'extrinsic apoptotic signaling pathway in absence of ligand', 'immune response', 'innate immune response in mucosa', 'macrophage activation', 'microglial cell activation', 'myeloid dendritic cell differentiation', 'negative regulation of acute inflammatory response', 'negative regulation of apoptotic process', 'negative regulation of cellular response to transforming growth factor beta stimulus', 'negative regulation of chronic inflammatory response', 'negative regulation of complement-dependent cytotoxicity', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of epithelial cell migration', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of inflammatory response', 'negative regulation of macrophage activation', 'negative regulation of neuroinflammatory response', 'negative regulation of osteoclast differentiation', 'negative regulation of T-helper 17 cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of tumor necrosis factor production', 'neuroinflammatory response', 'positive regulation of amyloid-beta clearance', 'positive regulation of ATP biosynthetic process', 'positive regulation of B cell proliferation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cellular respiration', 'positive regulation of cold-induced thermogenesis', 'positive regulation of defense response to virus by host', 'positive regulation of eosinophil chemotaxis', 'positive regulation of gene expression', 'positive regulation of interleukin-10 production', 'positive regulation of interleukin-13 production', 'positive regulation of isotype switching to IgE isotypes', 'positive regulation of isotype switching to IgG isotypes', 'positive regulation of macroautophagy', 'positive regulation of mast cell degranulation', 'positive regulation of MHC class II biosynthetic process', 'positive regulation of mononuclear cell migration', 'positive regulation of myoblast fusion', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of T cell differentiation', 'positive regulation of T cell proliferation', 'positive regulation of T-helper 2 cell cytokine production', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of tyrosine phosphorylation of STAT protein', 'regulation of immune response', 'regulation of isotype switching', 'regulation of phosphorylation', 'T cell activation', 'T-helper 2 cell differentiation', 'type 2 immune response']['cell surface receptor signaling pathway', 'cytokine-mediated signaling pathway', 'oncostatin-M-mediated signaling pathway', 'positive regulation of cell population proliferation']
Endothelin-1
63
Endothelin-1
55
9.1
53
0.21
P05305P05305['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'artery smooth muscle contraction', 'axon extension', 'axonogenesis involved in innervation', 'body fluid secretion', 'branching involved in blood vessel morphogenesis', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cardiac neural crest cell migration involved in outflow tract morphogenesis', 'cartilage development', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to calcium ion', 'cellular response to fatty acid', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to human chorionic gonadotropin stimulus', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to luteinizing hormone stimulus', 'cellular response to mineralocorticoid stimulus', 'cellular response to organic substance', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to xenobiotic stimulus', 'dorsal/ventral pattern formation', 'embryonic heart tube development', 'endothelin receptor signaling pathway', 'endothelin receptor signaling pathway involved in heart process', 'epithelial fluid transport', 'ERK1 and ERK2 cascade', 'G protein-coupled receptor signaling pathway', 'histamine secretion', 'I-kappaB kinase/NF-kappaB signaling', 'in utero embryonic development', 'inositol phosphate-mediated signaling', 'leukocyte activation', 'maternal process involved in parturition', 'meiotic cell cycle process involved in oocyte maturation', 'membrane depolarization', 'middle ear morphogenesis', 'mitochondrion organization', 'multicellular organism aging', 'negative regulation of blood coagulation', 'negative regulation of gene expression', 'negative regulation of hormone secretion', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein metabolic process', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'neural crest cell fate commitment', 'nitric oxide transport', 'noradrenergic neuron differentiation', 'peptide hormone secretion', 'pharyngeal arch artery morphogenesis', 'phosphatidylinositol 3-kinase signaling', 'phospholipase D-activating G protein-coupled receptor signaling pathway', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cation channel activity', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell size', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell migration', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of JUN kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of odontogenesis', 'positive regulation of prostaglandin secretion', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'positive regulation of renal sodium excretion', 'positive regulation of sarcomere organization', 'positive regulation of signaling receptor activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'prostaglandin biosynthetic process', 'protein kinase A signaling', 'protein kinase C deactivation', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'regulation of glucose transmembrane transport', 'regulation of pH', 'regulation of sensory perception of pain', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'renal sodium ion absorption', 'respiratory gaseous exchange by respiratory system', 'response to activity', 'response to amino acid', 'response to amphetamine', 'response to dexamethasone', 'response to leptin', 'response to lipopolysaccharide', 'response to muscle stretch', 'response to nicotine', 'response to ozone', 'response to prostaglandin F', 'response to salt', 'response to testosterone', 'rhythmic excitation', 'semaphorin-plexin signaling pathway involved in axon guidance', 'sensory perception of pain', 'superoxide anion generation', 'sympathetic neuron axon guidance', 'thyroid gland development', 'transcription by RNA polymerase II', 'vasoconstriction', 'vein smooth muscle contraction']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'artery smooth muscle contraction', 'axon extension', 'axonogenesis involved in innervation', 'body fluid secretion', 'branching involved in blood vessel morphogenesis', 'calcium ion transmembrane transport', 'calcium-mediated signaling', 'canonical Wnt signaling pathway', 'cardiac neural crest cell migration involved in outflow tract morphogenesis', 'cartilage development', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to calcium ion', 'cellular response to fatty acid', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to human chorionic gonadotropin stimulus', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to luteinizing hormone stimulus', 'cellular response to mineralocorticoid stimulus', 'cellular response to organic substance', 'cellular response to transforming growth factor beta stimulus', 'cellular response to tumor necrosis factor', 'cellular response to xenobiotic stimulus', 'dorsal/ventral pattern formation', 'embryonic heart tube development', 'endothelin receptor signaling pathway', 'endothelin receptor signaling pathway involved in heart process', 'epithelial fluid transport', 'ERK1 and ERK2 cascade', 'G protein-coupled receptor signaling pathway', 'histamine secretion', 'I-kappaB kinase/NF-kappaB signaling', 'in utero embryonic development', 'inositol phosphate-mediated signaling', 'leukocyte activation', 'maternal process involved in parturition', 'meiotic cell cycle process involved in oocyte maturation', 'membrane depolarization', 'middle ear morphogenesis', 'mitochondrion organization', 'multicellular organism aging', 'negative regulation of blood coagulation', 'negative regulation of gene expression', 'negative regulation of hormone secretion', 'negative regulation of nitric-oxide synthase biosynthetic process', 'negative regulation of protein metabolic process', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'neural crest cell fate commitment', 'nitric oxide transport', 'noradrenergic neuron differentiation', 'peptide hormone secretion', 'pharyngeal arch artery morphogenesis', 'phosphatidylinositol 3-kinase signaling', 'phospholipase D-activating G protein-coupled receptor signaling pathway', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cation channel activity', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell size', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell migration', 'positive regulation of heart rate', 'positive regulation of hormone secretion', 'positive regulation of JUN kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of mitotic nuclear division', 'positive regulation of neutrophil chemotaxis', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of odontogenesis', 'positive regulation of prostaglandin secretion', 'positive regulation of prostaglandin-endoperoxide synthase activity', 'positive regulation of renal sodium excretion', 'positive regulation of sarcomere organization', 'positive regulation of signaling receptor activity', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of smooth muscle contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'prostaglandin biosynthetic process', 'protein kinase A signaling', 'protein kinase C deactivation', 'protein kinase C-activating G protein-coupled receptor signaling pathway', 'protein phosphorylation', 'regulation of glucose transmembrane transport', 'regulation of pH', 'regulation of sensory perception of pain', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of vasoconstriction', 'renal sodium ion absorption', 'respiratory gaseous exchange by respiratory system', 'response to activity', 'response to amino acid', 'response to amphetamine', 'response to dexamethasone', 'response to leptin', 'response to lipopolysaccharide', 'response to muscle stretch', 'response to nicotine', 'response to ozone', 'response to prostaglandin F', 'response to salt', 'response to testosterone', 'rhythmic excitation', 'semaphorin-plexin signaling pathway involved in axon guidance', 'sensory perception of pain', 'superoxide anion generation', 'sympathetic neuron axon guidance', 'thyroid gland development', 'transcription by RNA polymerase II', 'vasoconstriction', 'vein smooth muscle contraction']
Tumor necrosis factor receptor superfamily, member 25
399
Tumor necrosis factor receptor superfamily, member 25
399
4.4
79
0.29
B1AWN9B1AWN9['apoptotic process', 'signal transduction']['apoptotic process', 'signal transduction']
If kappa light chain
219
Igh protein
149
5.7
nan
nan
A2NHM3Q6PIP8[][]
Brain-derived neurotrophic factor
239
Neurotrophin-3
152
8.8
79
0.14
P23560P20783['axon guidance', 'brain-derived neurotrophic factor receptor signaling pathway', 'collateral sprouting', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of apoptotic signaling pathway', 'negative regulation of myotube differentiation', 'negative regulation of neuron apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'nervous system development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of brain-derived neurotrophic factor receptor signaling pathway', 'positive regulation of collateral sprouting', 'positive regulation of neuron projection development', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of receptor binding', 'positive regulation of synapse assembly', 'regulation of neuron differentiation', 'regulation of protein localization to cell surface', 'synapse assembly', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of GTPase activity', 'activation of protein kinase B activity', 'cell-cell signaling', 'induction of positive chemotaxis', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of peptidyl-tyrosine phosphorylation', 'nerve development', 'nerve growth factor signaling pathway', 'nervous system development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of MAP kinase activity', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of receptor internalization', 'regulation of apoptotic process', 'regulation of neuron differentiation', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Thioredoxin
73
Thioredoxin
32
7.5
76
0.18
P10599P10599['activation of protein kinase B activity', 'cell redox homeostasis', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of protein export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA binding', 'positive regulation of peptidyl-cysteine S-nitrosylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'response to nitric oxide', 'response to radiation']['activation of protein kinase B activity', 'cell redox homeostasis', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of protein export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA binding', 'positive regulation of peptidyl-cysteine S-nitrosylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'response to nitric oxide', 'response to radiation']
Hsc70-interacting protein
208
Hsc70-interacting protein
208
3.6
74
0.37
P50503P50503['chaperone cofactor-dependent protein refolding', 'negative regulation of protein refolding', 'response to bacterium']['chaperone cofactor-dependent protein refolding', 'negative regulation of protein refolding', 'response to bacterium']
Neutrophil defensin 1
83
Neutrophil defensin 1
73
9.7
72
0.14
P59665P59665['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemotaxis', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'defense response to protozoan', 'defense response to virus', 'immune response', 'innate immune response in mucosa', 'intracellular estrogen receptor signaling pathway', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'modification by host of symbiont membrane', 'T cell chemotaxis']
Interleukin-4
151
Cytokine receptor common subunit gamma
231
8.4
56
0.21
P05112P31785['activation of Janus kinase activity', 'B cell costimulation', 'B cell differentiation', 'cholesterol metabolic process', 'dendritic cell differentiation', 'extrinsic apoptotic signaling pathway in absence of ligand', 'immune response', 'innate immune response in mucosa', 'macrophage activation', 'microglial cell activation', 'myeloid dendritic cell differentiation', 'negative regulation of acute inflammatory response', 'negative regulation of apoptotic process', 'negative regulation of cellular response to transforming growth factor beta stimulus', 'negative regulation of chronic inflammatory response', 'negative regulation of complement-dependent cytotoxicity', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of epithelial cell migration', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of inflammatory response', 'negative regulation of macrophage activation', 'negative regulation of neuroinflammatory response', 'negative regulation of osteoclast differentiation', 'negative regulation of T-helper 17 cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of tumor necrosis factor production', 'neuroinflammatory response', 'positive regulation of amyloid-beta clearance', 'positive regulation of ATP biosynthetic process', 'positive regulation of B cell proliferation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cellular respiration', 'positive regulation of cold-induced thermogenesis', 'positive regulation of defense response to virus by host', 'positive regulation of eosinophil chemotaxis', 'positive regulation of gene expression', 'positive regulation of interleukin-10 production', 'positive regulation of interleukin-13 production', 'positive regulation of isotype switching to IgE isotypes', 'positive regulation of isotype switching to IgG isotypes', 'positive regulation of macroautophagy', 'positive regulation of mast cell degranulation', 'positive regulation of MHC class II biosynthetic process', 'positive regulation of mononuclear cell migration', 'positive regulation of myoblast fusion', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of T cell differentiation', 'positive regulation of T cell proliferation', 'positive regulation of T-helper 2 cell cytokine production', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of tyrosine phosphorylation of STAT protein', 'regulation of immune response', 'regulation of isotype switching', 'regulation of phosphorylation', 'T cell activation', 'T-helper 2 cell differentiation', 'type 2 immune response']['CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation', 'cytokine-mediated signaling pathway', 'gene expression', 'immune response', 'interleukin-15-mediated signaling pathway', 'interleukin-2-mediated signaling pathway', 'interleukin-4-mediated signaling pathway', 'interleukin-7-mediated signaling pathway', 'mature B cell differentiation', 'positive regulation of B cell differentiation', 'positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation', 'positive regulation of gene expression', 'positive regulation of phagocytosis', 'positive regulation of T cell differentiation in thymus', 'signal transduction', 'T cell differentiation in thymus']
F-box only protein 11
890
F-box only protein 11
865
7.0
64
0.22
Q86XK2Q86XK2['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']
Eukaryotic translation initiation factor 3 subunit J
207
Eukaryotic translation initiation factor 3 subunit J
188
9.3
68
0.16
O75822O75822['formation of cytoplasmic translation initiation complex', 'translational initiation']['formation of cytoplasmic translation initiation complex', 'translational initiation']
C-C chemokine receptor type 5
20
C-C motif chemokine 5
73
9.2
68
0.16
P51681P13501['calcium ion transport', 'calcium-mediated signaling', 'cell chemotaxis', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular defense response', 'cellular response to lipopolysaccharide', 'chemotaxis', 'dendritic cell chemotaxis', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'MAPK cascade', 'positive regulation of cytosolic calcium ion concentration', 'release of sequestered calcium ion into cytosol by sarcoplasmic reticulum', 'response to cholesterol', 'signaling']['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'chemokine-mediated signaling pathway', 'chemotaxis', 'dendritic cell chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of innate immune response', 'positive regulation of macrophage chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of translational initiation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of viral genome replication', 'protein kinase B signaling', 'regulation of chronic inflammatory response', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to toxic substance', 'response to virus']
Cryptochrome-2
430
Period circadian protein homolog 2
1210
6.3
78
0.2
Q9R194O54943['circadian regulation of gene expression', 'circadian rhythm', 'entrainment of circadian clock by photoperiod', 'glucose homeostasis', 'lipid storage', 'negative regulation of circadian rhythm', 'negative regulation of glucocorticoid receptor signaling pathway', 'negative regulation of glucocorticoid secretion', 'negative regulation of phosphoprotein phosphatase activity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'protein import into nucleus', 'regulation of circadian rhythm', 'regulation of sodium-dependent phosphate transport', 'response to activity', 'response to insulin', 'response to light stimulus']['circadian regulation of gene expression', 'circadian regulation of translation', 'circadian rhythm', 'entrainment of circadian clock by photoperiod', 'fatty acid metabolic process', 'gluconeogenesis', 'glycogen biosynthetic process', 'histone H3 deacetylation', 'lactate biosynthetic process', 'negative regulation of circadian rhythm', 'negative regulation of DNA-templated transcription, termination', 'negative regulation of fat cell proliferation', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription regulatory region DNA binding', 'negative regulation of transcription, DNA-templated', 'positive regulation of cold-induced thermogenesis', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of glutamate uptake involved in transmission of nerve impulse', 'regulation of insulin secretion', 'regulation of neurogenesis', 'regulation of vasoconstriction', 'response to ischemia', 'white fat cell differentiation']
Estrogen receptor
227
Estrogen receptor
227
5.9
65
0.26
P03372P03372['androgen metabolic process', 'antral ovarian follicle growth', 'cellular response to estradiol stimulus', 'cellular response to estrogen stimulus', 'chromatin remodeling', 'epithelial cell development', 'epithelial cell proliferation involved in mammary gland duct elongation', 'fibroblast proliferation', 'intracellular estrogen receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'male gonad development', 'mammary gland alveolus development', 'mammary gland branching involved in pregnancy', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of gene expression', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of miRNA maturation', 'negative regulation of transcription by RNA polymerase II', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of fibroblast proliferation', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of phospholipase C activity', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis', 'prostate epithelial cord elongation', 'protein localization to chromatin', 'regulation of branching involved in prostate gland morphogenesis', 'regulation of epithelial cell apoptotic process', 'regulation of inflammatory response', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to estradiol', 'response to estrogen', 'signal transduction', 'stem cell differentiation', 'transcription by RNA polymerase II', 'uterus development', 'vagina development']['androgen metabolic process', 'antral ovarian follicle growth', 'cellular response to estradiol stimulus', 'cellular response to estrogen stimulus', 'chromatin remodeling', 'epithelial cell development', 'epithelial cell proliferation involved in mammary gland duct elongation', 'fibroblast proliferation', 'intracellular estrogen receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'male gonad development', 'mammary gland alveolus development', 'mammary gland branching involved in pregnancy', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of gene expression', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of miRNA maturation', 'negative regulation of transcription by RNA polymerase II', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of fibroblast proliferation', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of phospholipase C activity', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis', 'prostate epithelial cord elongation', 'protein localization to chromatin', 'regulation of branching involved in prostate gland morphogenesis', 'regulation of epithelial cell apoptotic process', 'regulation of inflammatory response', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to estradiol', 'response to estrogen', 'signal transduction', 'stem cell differentiation', 'transcription by RNA polymerase II', 'uterus development', 'vagina development']
Cysteine desulfurase, mitochondrial
381
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
138
6.5
87
0.18
Q9Y697Q9H1K1['[2Fe-2S] cluster assembly', 'iron incorporation into metallo-sulfur cluster', 'iron-sulfur cluster assembly', 'Mo-molybdopterin cofactor biosynthetic process']['cellular iron ion homeostasis', 'iron-sulfur cluster assembly', 'negative regulation of iron ion import across plasma membrane', 'positive regulation of aconitate hydratase activity', 'positive regulation of mitochondrial electron transport, NADH to ubiquinone']
Cyclin-dependent kinase 4
78
Cyclin-dependent kinase inhibitor 1
41
6.0
75
0.22
P11802P38936['adipose tissue development', 'cell division', 'cellular response to insulin stimulus', 'cellular response to interleukin-4', 'cellular response to ionomycin', 'cellular response to lipopolysaccharide', 'cellular response to phorbol 13-acetate 12-myristate', 'G1/S transition of mitotic cell cycle', 'positive regulation of cell population proliferation', 'positive regulation of fibroblast proliferation', 'positive regulation of G2/M transition of mitotic cell cycle', 'protein phosphorylation', 'regulation of cell cycle', 'regulation of gene expression', 'regulation of insulin receptor signaling pathway', 'regulation of lipid biosynthetic process', 'regulation of lipid catabolic process', 'regulation of multicellular organism growth', 'regulation of transcription initiation from RNA polymerase II promoter', 'regulation of type B pancreatic cell proliferation', 'response to xenobiotic stimulus', 'signal transduction']['cellular response to amino acid starvation', 'cellular response to DNA damage stimulus', 'cellular response to extracellular stimulus', 'cellular response to gamma radiation', 'cellular response to ionizing radiation', 'cellular response to UV-B', 'cellular senescence', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator', 'G1/S transition of mitotic cell cycle', 'heart development', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'mitotic G2 DNA damage checkpoint signaling', 'negative regulation of cardiac muscle tissue regeneration', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cyclin-dependent protein kinase activity', 'negative regulation of cyclin-dependent protein serine/threonine kinase activity', 'negative regulation of DNA biosynthetic process', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of gene expression', 'negative regulation of phosphorylation', 'negative regulation of protein binding', 'negative regulation of vascular associated smooth muscle cell proliferation', 'positive regulation of B cell proliferation', 'positive regulation of fibroblast proliferation', 'positive regulation of programmed cell death', 'positive regulation of protein kinase activity', 'positive regulation of reactive oxygen species metabolic process', 'protein import into nucleus', 'Ras protein signal transduction', 'regulation of cell cycle', 'regulation of cell cycle G1/S phase transition', 'regulation of cyclin-dependent protein serine/threonine kinase activity', 'regulation of G1/S transition of mitotic cell cycle', 'regulation of G2/M transition of mitotic cell cycle', 'replicative senescence', 'stress-induced premature senescence', 'tissue regeneration', 'wound healing']
Defensin alpha 5
92
Defensin alpha 5
82
9.8
nan
nan
Q01523Q01523['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']
Cryptochrome-2
432
Period circadian protein homolog 2
1210
4.6
77
0.28
Q9R194O54943['circadian regulation of gene expression', 'circadian rhythm', 'entrainment of circadian clock by photoperiod', 'glucose homeostasis', 'lipid storage', 'negative regulation of circadian rhythm', 'negative regulation of glucocorticoid receptor signaling pathway', 'negative regulation of glucocorticoid secretion', 'negative regulation of phosphoprotein phosphatase activity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'protein import into nucleus', 'regulation of circadian rhythm', 'regulation of sodium-dependent phosphate transport', 'response to activity', 'response to insulin', 'response to light stimulus']['circadian regulation of gene expression', 'circadian regulation of translation', 'circadian rhythm', 'entrainment of circadian clock by photoperiod', 'fatty acid metabolic process', 'gluconeogenesis', 'glycogen biosynthetic process', 'histone H3 deacetylation', 'lactate biosynthetic process', 'negative regulation of circadian rhythm', 'negative regulation of DNA-templated transcription, termination', 'negative regulation of fat cell proliferation', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription regulatory region DNA binding', 'negative regulation of transcription, DNA-templated', 'positive regulation of cold-induced thermogenesis', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of glutamate uptake involved in transmission of nerve impulse', 'regulation of insulin secretion', 'regulation of neurogenesis', 'regulation of vasoconstriction', 'response to ischemia', 'white fat cell differentiation']
Insulin-like growth factor-binding protein 4
204
Insulin-like growth factor I
54
4.6
87
0.25
P22692P05019['inflammatory response', 'MAPK cascade', 'negative regulation of canonical Wnt signaling pathway', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'regulation of cell growth', 'regulation of glucose metabolic process', 'regulation of insulin-like growth factor receptor signaling pathway', 'signal transduction', 'type B pancreatic cell proliferation']['activation of protein kinase B activity', 'bone mineralization involved in bone maturation', 'cell activation', 'cell population proliferation', 'cellular response to amyloid-beta', 'ERK1 and ERK2 cascade', 'glycolate metabolic process', 'insulin-like growth factor receptor signaling pathway', 'muscle hypertrophy', 'muscle organ development', 'myoblast differentiation', 'myoblast proliferation', 'myotube cell development', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of gene expression', 'negative regulation of interleukin-1 beta production', 'negative regulation of neuroinflammatory response', 'negative regulation of oocyte development', 'negative regulation of release of cytochrome c from mitochondria', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of tumor necrosis factor production', 'negative regulation of vascular associated smooth muscle cell apoptotic process', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol-mediated signaling', 'positive regulation of activated T cell proliferation', 'positive regulation of calcineurin-NFAT signaling cascade', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of DNA binding', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Ras protein signal transduction', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of trophectodermal cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase B signaling', 'protein stabilization', 'proteoglycan biosynthetic process', 'Ras protein signal transduction', 'regulation of gene expression', 'regulation of multicellular organism growth', 'regulation of protein phosphorylation', 'response to heat', 'signal transduction', 'skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration', 'skeletal system development', 'wound healing']
E3 ubiquitin-protein ligase parkin
352
E3 ubiquitin-protein ligase parkin
323
9.0
64
0.17
Q9JK66Q9JK66['adult locomotory behavior', 'aggresome assembly', 'autophagy of mitochondrion', 'brain development', 'cellular response to hydrogen sulfide', 'cellular response to L-glutamate', 'cellular response to L-glutamine', 'cellular response to manganese ion', 'cellular response to toxic substance', 'dopamine metabolic process', 'dopamine uptake involved in synaptic transmission', 'free ubiquitin chain polymerization', 'learning', 'locomotory behavior', 'mitochondrial fission', 'mitochondrial fragmentation involved in apoptotic process', 'mitochondrion localization', 'mitochondrion organization', 'mitochondrion to lysosome transport', 'mitophagy', 'modulation of chemical synaptic transmission', 'negative regulation by host of viral genome replication', 'negative regulation of actin filament bundle assembly', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell death', 'negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of excitatory postsynaptic potential', 'negative regulation of exosomal secretion', 'negative regulation of gene expression', 'negative regulation of glucokinase activity', 'negative regulation of insulin secretion', 'negative regulation of intralumenal vesicle formation', 'negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'negative regulation of JNK cascade', 'negative regulation of mitochondrial fission', 'negative regulation of mitochondrial fusion', 'negative regulation of neuron apoptotic process', 'negative regulation of neuron death', 'negative regulation of oxidative stress-induced neuron death', 'negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of primary amine oxidase activity', 'negative regulation of protein phosphorylation', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of release of cytochrome c from mitochondria', 'negative regulation of spontaneous neurotransmitter secretion', 'negative regulation of synaptic transmission, glutamatergic', 'negative regulation of transcription by RNA polymerase II', 'neuron cellular homeostasis', 'norepinephrine metabolic process', 'parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization', 'positive regulation of apoptotic process', 'positive regulation of ATP biosynthetic process', 'positive regulation of autophagy of mitochondrion', 'positive regulation of dendrite extension', 'positive regulation of DNA binding', 'positive regulation of gene expression', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of mitochondrial fission', 'positive regulation of mitochondrial fusion', 'positive regulation of mitochondrial membrane potential', 'positive regulation of mitophagy', 'positive regulation of mitophagy in response to mitochondrial depolarization', 'positive regulation of neurotransmitter uptake', 'positive regulation of proteasomal protein catabolic process', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of protein binding', 'positive regulation of protein linear polyubiquitination', 'positive regulation of protein localization to membrane', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor-mediated signaling pathway', 'proteasomal protein catabolic process', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein autoubiquitination', 'protein destabilization', 'protein K11-linked ubiquitination', 'protein K48-linked ubiquitination', 'protein K6-linked ubiquitination', 'protein K63-linked ubiquitination', 'protein localization to mitochondrion', 'protein metabolic process', 'protein monoubiquitination', 'protein polyubiquitination', 'protein stabilization', 'protein ubiquitination', 'regulation of apoptotic process', 'regulation of autophagy', 'regulation of cellular response to oxidative stress', 'regulation of dopamine metabolic process', 'regulation of gene expression', 'regulation of mitochondrial membrane potential', 'regulation of mitochondrion organization', 'regulation of neurotransmitter secretion', 'regulation of protein stability', 'regulation of protein ubiquitination', 'regulation of reactive oxygen species metabolic process', 'response to corticosterone', 'response to curcumin', 'response to endoplasmic reticulum stress', 'response to muscle activity', 'response to oxidative stress', 'response to unfolded protein', 'response to xenobiotic stimulus', 'startle response', 'synaptic transmission, dopaminergic', 'synaptic transmission, glutamatergic', 'ubiquitin-dependent protein catabolic process', 'zinc ion homeostasis']['adult locomotory behavior', 'aggresome assembly', 'autophagy of mitochondrion', 'brain development', 'cellular response to hydrogen sulfide', 'cellular response to L-glutamate', 'cellular response to L-glutamine', 'cellular response to manganese ion', 'cellular response to toxic substance', 'dopamine metabolic process', 'dopamine uptake involved in synaptic transmission', 'free ubiquitin chain polymerization', 'learning', 'locomotory behavior', 'mitochondrial fission', 'mitochondrial fragmentation involved in apoptotic process', 'mitochondrion localization', 'mitochondrion organization', 'mitochondrion to lysosome transport', 'mitophagy', 'modulation of chemical synaptic transmission', 'negative regulation by host of viral genome replication', 'negative regulation of actin filament bundle assembly', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell death', 'negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of excitatory postsynaptic potential', 'negative regulation of exosomal secretion', 'negative regulation of gene expression', 'negative regulation of glucokinase activity', 'negative regulation of insulin secretion', 'negative regulation of intralumenal vesicle formation', 'negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'negative regulation of JNK cascade', 'negative regulation of mitochondrial fission', 'negative regulation of mitochondrial fusion', 'negative regulation of neuron apoptotic process', 'negative regulation of neuron death', 'negative regulation of oxidative stress-induced neuron death', 'negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of primary amine oxidase activity', 'negative regulation of protein phosphorylation', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of release of cytochrome c from mitochondria', 'negative regulation of spontaneous neurotransmitter secretion', 'negative regulation of synaptic transmission, glutamatergic', 'negative regulation of transcription by RNA polymerase II', 'neuron cellular homeostasis', 'norepinephrine metabolic process', 'parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization', 'positive regulation of apoptotic process', 'positive regulation of ATP biosynthetic process', 'positive regulation of autophagy of mitochondrion', 'positive regulation of dendrite extension', 'positive regulation of DNA binding', 'positive regulation of gene expression', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of mitochondrial fission', 'positive regulation of mitochondrial fusion', 'positive regulation of mitochondrial membrane potential', 'positive regulation of mitophagy', 'positive regulation of mitophagy in response to mitochondrial depolarization', 'positive regulation of neurotransmitter uptake', 'positive regulation of proteasomal protein catabolic process', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of protein binding', 'positive regulation of protein linear polyubiquitination', 'positive regulation of protein localization to membrane', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor-mediated signaling pathway', 'proteasomal protein catabolic process', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein autoubiquitination', 'protein destabilization', 'protein K11-linked ubiquitination', 'protein K48-linked ubiquitination', 'protein K6-linked ubiquitination', 'protein K63-linked ubiquitination', 'protein localization to mitochondrion', 'protein metabolic process', 'protein monoubiquitination', 'protein polyubiquitination', 'protein stabilization', 'protein ubiquitination', 'regulation of apoptotic process', 'regulation of autophagy', 'regulation of cellular response to oxidative stress', 'regulation of dopamine metabolic process', 'regulation of gene expression', 'regulation of mitochondrial membrane potential', 'regulation of mitochondrion organization', 'regulation of neurotransmitter secretion', 'regulation of protein stability', 'regulation of protein ubiquitination', 'regulation of reactive oxygen species metabolic process', 'response to corticosterone', 'response to curcumin', 'response to endoplasmic reticulum stress', 'response to muscle activity', 'response to oxidative stress', 'response to unfolded protein', 'response to xenobiotic stimulus', 'startle response', 'synaptic transmission, dopaminergic', 'synaptic transmission, glutamatergic', 'ubiquitin-dependent protein catabolic process', 'zinc ion homeostasis']
Killer cell lectin-like receptor 3
149
Killer cell lectin-like receptor 3
149
4.6
68
0.32
Q64329Q64329['cell adhesion']['cell adhesion']
Killer cell lectin-like receptor 3
154
Killer cell lectin-like receptor 3
149
4.9
75
0.27
Q64329Q64329['cell adhesion']['cell adhesion']
Interleukin-4
151
Cytokine receptor common subunit gamma
182
8.9
57
0.2
P05112P31785['activation of Janus kinase activity', 'B cell costimulation', 'B cell differentiation', 'cholesterol metabolic process', 'dendritic cell differentiation', 'extrinsic apoptotic signaling pathway in absence of ligand', 'immune response', 'innate immune response in mucosa', 'macrophage activation', 'microglial cell activation', 'myeloid dendritic cell differentiation', 'negative regulation of acute inflammatory response', 'negative regulation of apoptotic process', 'negative regulation of cellular response to transforming growth factor beta stimulus', 'negative regulation of chronic inflammatory response', 'negative regulation of complement-dependent cytotoxicity', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of epithelial cell migration', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of inflammatory response', 'negative regulation of macrophage activation', 'negative regulation of neuroinflammatory response', 'negative regulation of osteoclast differentiation', 'negative regulation of T-helper 17 cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of tumor necrosis factor production', 'neuroinflammatory response', 'positive regulation of amyloid-beta clearance', 'positive regulation of ATP biosynthetic process', 'positive regulation of B cell proliferation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cellular respiration', 'positive regulation of cold-induced thermogenesis', 'positive regulation of defense response to virus by host', 'positive regulation of eosinophil chemotaxis', 'positive regulation of gene expression', 'positive regulation of interleukin-10 production', 'positive regulation of interleukin-13 production', 'positive regulation of isotype switching to IgE isotypes', 'positive regulation of isotype switching to IgG isotypes', 'positive regulation of macroautophagy', 'positive regulation of mast cell degranulation', 'positive regulation of MHC class II biosynthetic process', 'positive regulation of mononuclear cell migration', 'positive regulation of myoblast fusion', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of T cell differentiation', 'positive regulation of T cell proliferation', 'positive regulation of T-helper 2 cell cytokine production', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of tyrosine phosphorylation of STAT protein', 'regulation of immune response', 'regulation of isotype switching', 'regulation of phosphorylation', 'T cell activation', 'T-helper 2 cell differentiation', 'type 2 immune response']['CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation', 'cytokine-mediated signaling pathway', 'gene expression', 'immune response', 'interleukin-15-mediated signaling pathway', 'interleukin-2-mediated signaling pathway', 'interleukin-4-mediated signaling pathway', 'interleukin-7-mediated signaling pathway', 'mature B cell differentiation', 'positive regulation of B cell differentiation', 'positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation', 'positive regulation of gene expression', 'positive regulation of phagocytosis', 'positive regulation of T cell differentiation in thymus', 'signal transduction', 'T cell differentiation in thymus']
cAMP-dependent protein kinase catalytic subunit alpha
200
cAMP-dependent protein kinase type II-beta regulatory subunit
114
4.8
78
0.27
P05132P12369['cellular response to cold', 'cellular response to glucose stimulus', 'cellular response to heat', 'cellular response to parathyroid hormone stimulus', 'mesoderm formation', 'modulation of chemical synaptic transmission', 'mRNA processing', 'negative regulation of meiotic cell cycle', 'negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning', 'neural tube closure', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of cell population proliferation', 'positive regulation of protein export from nucleus', 'protein autophosphorylation', 'protein export from nucleus', 'protein kinase A signaling', 'protein localization to lipid droplet', 'protein phosphorylation', 'regulation of bicellular tight junction assembly', 'regulation of cell cycle', 'regulation of cellular respiration', 'regulation of osteoblast differentiation', 'regulation of proteasomal protein catabolic process', 'regulation of protein processing', 'regulation of synaptic transmission, glutamatergic', 'sperm capacitation', 'spontaneous exocytosis of neurotransmitter']['fatty acid metabolic process', 'learning', 'modulation of chemical synaptic transmission', 'negative regulation of cAMP-dependent protein kinase activity', 'regulation of protein kinase activity', 'response to antipsychotic drug', 'response to clozapine']
C-C chemokine receptor type 5
20
C-C motif chemokine 5
57
8.9
77
0.15
P51681P13501['calcium ion transport', 'calcium-mediated signaling', 'cell chemotaxis', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular defense response', 'cellular response to lipopolysaccharide', 'chemotaxis', 'dendritic cell chemotaxis', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'MAPK cascade', 'positive regulation of cytosolic calcium ion concentration', 'release of sequestered calcium ion into cytosol by sarcoplasmic reticulum', 'response to cholesterol', 'signaling']['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'chemokine-mediated signaling pathway', 'chemotaxis', 'dendritic cell chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of innate immune response', 'positive regulation of macrophage chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of translational initiation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of viral genome replication', 'protein kinase B signaling', 'regulation of chronic inflammatory response', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to toxic substance', 'response to virus']
Brain-derived neurotrophic factor
141
Neurotrophin-3
248
8.9
84
0.13
P23560P20783['axon guidance', 'brain-derived neurotrophic factor receptor signaling pathway', 'collateral sprouting', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of apoptotic signaling pathway', 'negative regulation of myotube differentiation', 'negative regulation of neuron apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'nervous system development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of brain-derived neurotrophic factor receptor signaling pathway', 'positive regulation of collateral sprouting', 'positive regulation of neuron projection development', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of receptor binding', 'positive regulation of synapse assembly', 'regulation of neuron differentiation', 'regulation of protein localization to cell surface', 'synapse assembly', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of GTPase activity', 'activation of protein kinase B activity', 'cell-cell signaling', 'induction of positive chemotaxis', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of peptidyl-tyrosine phosphorylation', 'nerve development', 'nerve growth factor signaling pathway', 'nervous system development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of MAP kinase activity', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of receptor internalization', 'regulation of apoptotic process', 'regulation of neuron differentiation', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway']
F-box only protein 11
888
F-box only protein 11
865
3.9
61
0.42
Q86XK2Q86XK2['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']
cAMP-dependent protein kinase catalytic subunit alpha
200
cAMP-dependent protein kinase type II-alpha regulatory subunit
98
5.1
67
0.29
P05132P12367['cellular response to cold', 'cellular response to glucose stimulus', 'cellular response to heat', 'cellular response to parathyroid hormone stimulus', 'mesoderm formation', 'modulation of chemical synaptic transmission', 'mRNA processing', 'negative regulation of meiotic cell cycle', 'negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning', 'neural tube closure', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of cell population proliferation', 'positive regulation of protein export from nucleus', 'protein autophosphorylation', 'protein export from nucleus', 'protein kinase A signaling', 'protein localization to lipid droplet', 'protein phosphorylation', 'regulation of bicellular tight junction assembly', 'regulation of cell cycle', 'regulation of cellular respiration', 'regulation of osteoblast differentiation', 'regulation of proteasomal protein catabolic process', 'regulation of protein processing', 'regulation of synaptic transmission, glutamatergic', 'sperm capacitation', 'spontaneous exocytosis of neurotransmitter']['modulation of chemical synaptic transmission', 'negative regulation of cAMP-dependent protein kinase activity', 'regulation of protein kinase activity']
Integrin alpha-X
655
Integrin alpha-X
712
6.1
71
0.23
P20702P20702['animal organ morphogenesis', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell-cell adhesion', 'cell-matrix adhesion', 'defense response to virus', 'heterotypic cell-cell adhesion', 'integrin-mediated signaling pathway', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of endothelial tube morphogenesis', 'positive regulation of gene expression', 'positive regulation of myelination']['animal organ morphogenesis', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell-cell adhesion', 'cell-matrix adhesion', 'defense response to virus', 'heterotypic cell-cell adhesion', 'integrin-mediated signaling pathway', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of endothelial tube morphogenesis', 'positive regulation of gene expression', 'positive regulation of myelination']
Cytidine deaminase
102
Cytidine deaminase
59
6.1
90
0.18
P56389P56389['cellular response to external biotic stimulus', 'CMP catabolic process', 'cytidine deamination', 'dCMP catabolic process', 'negative regulation of cell growth', 'negative regulation of nucleotide metabolic process', 'response to cycloheximide', 'UMP salvage']['cellular response to external biotic stimulus', 'CMP catabolic process', 'cytidine deamination', 'dCMP catabolic process', 'negative regulation of cell growth', 'negative regulation of nucleotide metabolic process', 'response to cycloheximide', 'UMP salvage']
Ephrin type-A receptor 1
969
Ephrin type-A receptor 1
969
6.1
59
0.28
P21709P21709['activation of GTPase activity', 'angiogenesis', 'axon guidance', 'cell surface receptor signaling pathway', 'negative regulation of cell migration', 'negative regulation of protein kinase activity', 'peptidyl-tyrosine phosphorylation', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell-matrix adhesion', 'positive regulation of kinase activity', 'positive regulation of stress fiber assembly', 'protein autophosphorylation', 'regulation of GTPase activity', 'substrate adhesion-dependent cell spreading', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of GTPase activity', 'angiogenesis', 'axon guidance', 'cell surface receptor signaling pathway', 'negative regulation of cell migration', 'negative regulation of protein kinase activity', 'peptidyl-tyrosine phosphorylation', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell-matrix adhesion', 'positive regulation of kinase activity', 'positive regulation of stress fiber assembly', 'protein autophosphorylation', 'regulation of GTPase activity', 'substrate adhesion-dependent cell spreading', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Histone H3.3
111
Histone H3.3
111
6.1
82
0.2
P84243P84243['cell population proliferation', 'DNA replication-independent chromatin assembly', 'embryo implantation', 'histone H3-S10 phosphorylation', 'histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore', 'male gonad development', 'multicellular organism growth', 'muscle cell differentiation', 'negative regulation of chromosome condensation', 'nucleosome assembly', 'nucleus organization', 'oocyte maturation', 'osteoblast differentiation', 'pericentric heterochromatin assembly', 'positive regulation of cell growth', 'regulation of centromere complex assembly', 'single fertilization', 'spermatid development', 'subtelomeric heterochromatin assembly', 'telomere organization']['cell population proliferation', 'DNA replication-independent chromatin assembly', 'embryo implantation', 'histone H3-S10 phosphorylation', 'histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore', 'male gonad development', 'multicellular organism growth', 'muscle cell differentiation', 'negative regulation of chromosome condensation', 'nucleosome assembly', 'nucleus organization', 'oocyte maturation', 'osteoblast differentiation', 'pericentric heterochromatin assembly', 'positive regulation of cell growth', 'regulation of centromere complex assembly', 'single fertilization', 'spermatid development', 'subtelomeric heterochromatin assembly', 'telomere organization']
Histone H3.1
111
Histone H3.1
111
6.1
85
0.19
P68433P68433['DNA replication-dependent chromatin assembly', 'nucleosome assembly', 'regulation of gene expression, epigenetic']['DNA replication-dependent chromatin assembly', 'nucleosome assembly', 'regulation of gene expression, epigenetic']
Phospholipase A2, membrane associated
103
Phospholipase A2, membrane associated
79
6.1
76
0.21
P14555P14555['arachidonic acid secretion', 'cytolysis', 'defense response to Gram-positive bacterium', 'inflammatory response', 'intestinal stem cell homeostasis', 'lipid catabolic process', 'low-density lipoprotein particle remodeling', 'phosphatidic acid metabolic process', 'phosphatidylcholine metabolic process', 'phosphatidylethanolamine metabolic process', 'phospholipid metabolic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of inflammatory response', 'positive regulation of macrophage derived foam cell differentiation', 'regulation of neutrophil activation']['arachidonic acid secretion', 'cytolysis', 'defense response to Gram-positive bacterium', 'inflammatory response', 'intestinal stem cell homeostasis', 'lipid catabolic process', 'low-density lipoprotein particle remodeling', 'phosphatidic acid metabolic process', 'phosphatidylcholine metabolic process', 'phosphatidylethanolamine metabolic process', 'phospholipid metabolic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of inflammatory response', 'positive regulation of macrophage derived foam cell differentiation', 'regulation of neutrophil activation']
Secreted frizzled-related protein 3
108
Secreted frizzled-related protein 3
108
6.2
77
0.21
P97401P97401['canonical Wnt signaling pathway', 'cochlea morphogenesis', 'convergent extension involved in organogenesis', 'epithelial cell development', 'hepatocyte differentiation', 'inner ear morphogenesis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cartilage development', 'negative regulation of cell development', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of hepatocyte differentiation', 'negative regulation of Wnt signaling pathway', 'neural crest cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of fat cell differentiation', 'somite development']['canonical Wnt signaling pathway', 'cochlea morphogenesis', 'convergent extension involved in organogenesis', 'epithelial cell development', 'hepatocyte differentiation', 'inner ear morphogenesis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cartilage development', 'negative regulation of cell development', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of hepatocyte differentiation', 'negative regulation of Wnt signaling pathway', 'neural crest cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of fat cell differentiation', 'somite development']
Histone H3.2
111
Histone H3.2
111
6.1
83
0.2
Q71DI3Q71DI3['nucleosome assembly']['nucleosome assembly']
S-phase kinase-associated protein 2
111
S-phase kinase-associated protein 1
120
6.1
65
0.25
Q13309P63208['defense response to virus', 'G1/S transition of mitotic cell cycle', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'positive regulation of intracellular estrogen receptor signaling pathway', 'positive regulation of protein polyubiquitination', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein K48-linked ubiquitination', 'regulation of apoptotic process', 'regulation of cell cycle', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process']['histone H2A monoubiquitination', 'maintenance of protein location in nucleus', 'positive regulation of ubiquitin protein ligase activity', 'protein K48-linked ubiquitination', 'protein polyubiquitination', 'protein ubiquitination', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process']
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
236
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
254
6.2
89
0.18
P50213O43837['carbohydrate metabolic process', 'isocitrate metabolic process', 'tricarboxylic acid cycle']['2-oxoglutarate metabolic process', 'isocitrate metabolic process', 'NADH metabolic process', 'tricarboxylic acid cycle']
3-hydroxyisobutyrate dehydrogenase, mitochondrial
251
3-hydroxyisobutyrate dehydrogenase, mitochondrial
251
6.2
96
0.17
P31937P31937['valine catabolic process']['valine catabolic process']
Alanine--glyoxylate aminotransferase
84
Alanine--glyoxylate aminotransferase
84
6.2
93
0.17
P21549P21549['glycine biosynthetic process, by transamination of glyoxylate', 'glyoxylate catabolic process', 'glyoxylate metabolic process', 'L-alanine catabolic process', 'L-cysteine catabolic process', 'L-serine metabolic process', 'Notch signaling pathway', 'oxalic acid secretion']['glycine biosynthetic process, by transamination of glyoxylate', 'glyoxylate catabolic process', 'glyoxylate metabolic process', 'L-alanine catabolic process', 'L-cysteine catabolic process', 'L-serine metabolic process', 'Notch signaling pathway', 'oxalic acid secretion']
Glucocorticoid receptor
482
Glucocorticoid receptor
482
6.6
69
0.22
P06536P06536['adrenal gland development', 'aging', 'androgen metabolic process', 'brain development', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to magnesium ion', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin remodeling', 'circadian rhythm', 'epigenetic maintenance of chromatin in transcription-competent conformation', 'female pregnancy', 'glucocorticoid metabolic process', 'glucocorticoid receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lung development', 'mammary gland duct morphogenesis', 'maternal behavior', 'muscle atrophy', 'negative regulation of apoptotic process', 'negative regulation of synaptic plasticity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular permeability', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of dendritic spine development', 'positive regulation of glucocorticoid receptor signaling pathway', 'positive regulation of glutamate secretion', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'protein-containing complex assembly', 'regulation of cell population proliferation', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of glucose metabolic process', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to activity', 'response to arsenic-containing substance', 'response to calcium ion', 'response to corticosterone', 'response to dexamethasone', 'response to electrical stimulus', 'response to inactivity', 'response to insulin', 'response to mercury ion', 'response to radiation']['adrenal gland development', 'aging', 'androgen metabolic process', 'brain development', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to magnesium ion', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin remodeling', 'circadian rhythm', 'epigenetic maintenance of chromatin in transcription-competent conformation', 'female pregnancy', 'glucocorticoid metabolic process', 'glucocorticoid receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lung development', 'mammary gland duct morphogenesis', 'maternal behavior', 'muscle atrophy', 'negative regulation of apoptotic process', 'negative regulation of synaptic plasticity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular permeability', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of dendritic spine development', 'positive regulation of glucocorticoid receptor signaling pathway', 'positive regulation of glutamate secretion', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'protein-containing complex assembly', 'regulation of cell population proliferation', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of glucose metabolic process', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to activity', 'response to arsenic-containing substance', 'response to calcium ion', 'response to corticosterone', 'response to dexamethasone', 'response to electrical stimulus', 'response to inactivity', 'response to insulin', 'response to mercury ion', 'response to radiation']
Serine/threonine-protein kinase PAK 1
360
Serine/threonine-protein kinase PAK 1
360
6.6
72
0.21
Q13153Q13153['actin cytoskeleton reorganization', 'apoptotic process', 'branching morphogenesis of an epithelial tube', 'cell migration', 'cellular response to DNA damage stimulus', 'chromatin remodeling', 'ephrin receptor signaling pathway', 'exocytosis', 'Fc-gamma receptor signaling pathway involved in phagocytosis', 'hepatocyte growth factor receptor signaling pathway', 'intracellular signal transduction', 'negative regulation of cell proliferation involved in contact inhibition', 'neuron projection morphogenesis', 'phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of intracellular estrogen receptor signaling pathway', 'positive regulation of JUN kinase activity', 'positive regulation of microtubule nucleation', 'positive regulation of microtubule polymerization', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein phosphorylation', 'positive regulation of stress fiber assembly', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of actin cytoskeleton organization', 'regulation of axonogenesis', 'regulation of MAPK cascade', 'stimulatory C-type lectin receptor signaling pathway', 'wound healing']['actin cytoskeleton reorganization', 'apoptotic process', 'branching morphogenesis of an epithelial tube', 'cell migration', 'cellular response to DNA damage stimulus', 'chromatin remodeling', 'ephrin receptor signaling pathway', 'exocytosis', 'Fc-gamma receptor signaling pathway involved in phagocytosis', 'hepatocyte growth factor receptor signaling pathway', 'intracellular signal transduction', 'negative regulation of cell proliferation involved in contact inhibition', 'neuron projection morphogenesis', 'phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of intracellular estrogen receptor signaling pathway', 'positive regulation of JUN kinase activity', 'positive regulation of microtubule nucleation', 'positive regulation of microtubule polymerization', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein phosphorylation', 'positive regulation of stress fiber assembly', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of actin cytoskeleton organization', 'regulation of axonogenesis', 'regulation of MAPK cascade', 'stimulatory C-type lectin receptor signaling pathway', 'wound healing']
NKG2-D type II integral membrane protein
105
NKG2-D type II integral membrane protein
105
6.6
86
0.18
P26718P26718['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of interferon-gamma production', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of nitric oxide biosynthetic process', 'signal transduction', 'stimulatory C-type lectin receptor signaling pathway', 'T cell costimulation']['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of interferon-gamma production', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of nitric oxide biosynthetic process', 'signal transduction', 'stimulatory C-type lectin receptor signaling pathway', 'T cell costimulation']
BTB/POZ domain-containing protein KCTD16
250
BTB/POZ domain-containing protein KCTD16
250
6.6
85
0.18
Q68DU8Q68DU8['protein homooligomerization', 'regulation of G protein-coupled receptor signaling pathway']['protein homooligomerization', 'regulation of G protein-coupled receptor signaling pathway']
ATP-binding cassette sub-family G member 8
311
ATP-binding cassette sub-family G member 5
291
6.6
50
0.3
Q9H221Q9H222['bile acid signaling pathway', 'cholesterol efflux', 'cholesterol homeostasis', 'intestinal cholesterol absorption', 'negative regulation of intestinal cholesterol absorption', 'negative regulation of intestinal phytosterol absorption', 'phospholipid transport', 'response to muscle activity', 'response to nutrient', 'response to xenobiotic stimulus', 'sterol transport', 'transmembrane transport', 'triglyceride homeostasis']['bile acid signaling pathway', 'cholesterol efflux', 'cholesterol homeostasis', 'intestinal cholesterol absorption', 'negative regulation of intestinal cholesterol absorption', 'negative regulation of intestinal phytosterol absorption', 'response to ionizing radiation', 'response to muscle activity', 'response to nutrient', 'response to xenobiotic stimulus', 'sterol transport', 'transmembrane transport', 'triglyceride homeostasis']
Neurogenic locus notch homolog protein 3
1484
Neurogenic locus notch homolog protein 3
1484
6.6
60
0.25
Q9UM47Q9UM47['artery morphogenesis', 'axon guidance', 'forebrain development', 'glomerular capillary formation', 'negative regulation of neuron differentiation', 'negative regulation of transcription by RNA polymerase II', 'neuroblast differentiation', 'neuron fate commitment', 'Notch signaling pathway', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II']['artery morphogenesis', 'axon guidance', 'forebrain development', 'glomerular capillary formation', 'negative regulation of neuron differentiation', 'negative regulation of transcription by RNA polymerase II', 'neuroblast differentiation', 'neuron fate commitment', 'Notch signaling pathway', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II']
Protein fem-1 homolog C
64
Protein fem-1 homolog C
64
6.6
72
0.21
Q96JP0Q96JP0['proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination', 'ubiquitin-dependent protein catabolic process', 'ubiquitin-dependent protein catabolic process via the C-end degron rule pathway']['proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination', 'ubiquitin-dependent protein catabolic process', 'ubiquitin-dependent protein catabolic process via the C-end degron rule pathway']
Serine/threonine-protein kinase RIO2
268
Serine/threonine-protein kinase RIO2
268
6.6
66
0.23
Q9BVS4Q9BVS4['cell cycle', 'maturation of SSU-rRNA', 'positive regulation of ribosomal small subunit export from nucleus', 'positive regulation of rRNA processing', 'protein autophosphorylation', 'regulation of mitotic metaphase/anaphase transition', 'ribosomal small subunit biogenesis']['cell cycle', 'maturation of SSU-rRNA', 'positive regulation of ribosomal small subunit export from nucleus', 'positive regulation of rRNA processing', 'protein autophosphorylation', 'regulation of mitotic metaphase/anaphase transition', 'ribosomal small subunit biogenesis']
Bone morphogenetic protein 6
478
Bone morphogenetic protein 6
477
6.6
84
0.18
P22004P22004['BMP signaling pathway', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'cellular response to iron ion', 'cellular response to mechanical stimulus', 'endochondral ossification', 'eye development', 'immune response', 'inflammatory response', 'kidney development', 'male genitalia development', 'multicellular organismal iron ion homeostasis', 'negative regulation of adherens junction organization', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of transcription by RNA polymerase II', 'neuron differentiation', 'osteoblast differentiation', 'positive regulation of aldosterone biosynthetic process', 'positive regulation of aldosterone secretion', 'positive regulation of bone mineralization', 'positive regulation of cell population proliferation', 'positive regulation of chondrocyte differentiation', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of gene expression', 'positive regulation of lipopolysaccharide-mediated signaling pathway', 'positive regulation of neuron differentiation', 'positive regulation of osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vascular permeability', 'response to activity', 'response to glucocorticoid', 'response to magnesium ion', 'response to retinoic acid', 'skeletal system development', 'SMAD protein signal transduction', 'type B pancreatic cell development']['BMP signaling pathway', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'cellular response to iron ion', 'cellular response to mechanical stimulus', 'endochondral ossification', 'eye development', 'immune response', 'inflammatory response', 'kidney development', 'male genitalia development', 'multicellular organismal iron ion homeostasis', 'negative regulation of adherens junction organization', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of transcription by RNA polymerase II', 'neuron differentiation', 'osteoblast differentiation', 'positive regulation of aldosterone biosynthetic process', 'positive regulation of aldosterone secretion', 'positive regulation of bone mineralization', 'positive regulation of cell population proliferation', 'positive regulation of chondrocyte differentiation', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of gene expression', 'positive regulation of lipopolysaccharide-mediated signaling pathway', 'positive regulation of neuron differentiation', 'positive regulation of osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vascular permeability', 'response to activity', 'response to glucocorticoid', 'response to magnesium ion', 'response to retinoic acid', 'skeletal system development', 'SMAD protein signal transduction', 'type B pancreatic cell development']
Histone H3.3
111
Histone H3.3
111
6.1
82
0.2
P84244P84244['cell population proliferation', 'DNA replication-independent chromatin assembly', 'embryo implantation', 'male gonad development', 'multicellular organism growth', 'muscle cell differentiation', 'negative regulation of chromosome condensation', 'nucleosome assembly', 'nucleus organization', 'oocyte maturation', 'oogenesis', 'osteoblast differentiation', 'pericentric heterochromatin assembly', 'positive regulation of cell growth', 'regulation of centromere complex assembly', 'single fertilization', 'spermatid development', 'spermatogenesis', 'subtelomeric heterochromatin assembly']['cell population proliferation', 'DNA replication-independent chromatin assembly', 'embryo implantation', 'male gonad development', 'multicellular organism growth', 'muscle cell differentiation', 'negative regulation of chromosome condensation', 'nucleosome assembly', 'nucleus organization', 'oocyte maturation', 'oogenesis', 'osteoblast differentiation', 'pericentric heterochromatin assembly', 'positive regulation of cell growth', 'regulation of centromere complex assembly', 'single fertilization', 'spermatid development', 'spermatogenesis', 'subtelomeric heterochromatin assembly']
DNA repair protein XRCC4
165
DNA repair protein XRCC4
165
6.1
65
0.25
Q13426Q13426['DNA ligation involved in DNA repair', 'double-strand break repair', 'double-strand break repair via nonhomologous end joining', 'immunoglobulin V(D)J recombination', 'positive regulation of ligase activity', 'positive regulation of phosphatidylserine exposure on apoptotic cell surface', 'protein localization to site of double-strand break', 'response to X-ray']['DNA ligation involved in DNA repair', 'double-strand break repair', 'double-strand break repair via nonhomologous end joining', 'immunoglobulin V(D)J recombination', 'positive regulation of ligase activity', 'positive regulation of phosphatidylserine exposure on apoptotic cell surface', 'protein localization to site of double-strand break', 'response to X-ray']
Interleukin-1 receptor-associated kinase 4
276
Interleukin-1 receptor-associated kinase 4
276
6.1
67
0.24
Q9NWZ3Q9NWZ3['cytokine-mediated signaling pathway', 'innate immune response', 'interleukin-1-mediated signaling pathway', 'intracellular signal transduction', 'JNK cascade', 'MyD88-dependent toll-like receptor signaling pathway', 'neutrophil mediated immunity', 'neutrophil migration', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of smooth muscle cell proliferation', 'protein phosphorylation', 'toll-like receptor 9 signaling pathway', 'toll-like receptor signaling pathway']['cytokine-mediated signaling pathway', 'innate immune response', 'interleukin-1-mediated signaling pathway', 'intracellular signal transduction', 'JNK cascade', 'MyD88-dependent toll-like receptor signaling pathway', 'neutrophil mediated immunity', 'neutrophil migration', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of smooth muscle cell proliferation', 'protein phosphorylation', 'toll-like receptor 9 signaling pathway', 'toll-like receptor signaling pathway']
Tyrosine-protein kinase BTK
481
Baculoviral IAP repeat-containing protein 2
315
6.6
64
0.24
Q06187Q13490['adaptive immune response', 'apoptotic signaling pathway', 'B cell activation', 'B cell affinity maturation', 'B cell receptor signaling pathway', 'calcium-mediated signaling', 'cell maturation', 'cellular response to interleukin-7', 'cellular response to molecule of fungal origin', 'cellular response to reactive oxygen species', 'eosinophil homeostasis', 'Fc-epsilon receptor signaling pathway', 'histamine secretion by mast cell', 'I-kappaB kinase/NF-kappaB signaling', 'innate immune response', 'intracellular signal transduction', 'mesoderm development', 'monocyte proliferation', 'MyD88-dependent toll-like receptor signaling pathway', 'negative regulation of B cell proliferation', 'negative regulation of interleukin-10 production', 'neutrophil homeostasis', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of B cell differentiation', 'positive regulation of B cell proliferation', 'positive regulation of immunoglobulin production', 'positive regulation of interleukin-17A production', 'positive regulation of interleukin-6 production', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of phagocytosis', 'positive regulation of synoviocyte proliferation', 'positive regulation of tumor necrosis factor production', 'positive regulation of type I hypersensitivity', 'positive regulation of type III hypersensitivity', 'protein phosphorylation', 'proteoglycan catabolic process', 'regulation of B cell apoptotic process', 'regulation of B cell cytokine production', 'response to lipopolysaccharide']['cell surface receptor signaling pathway', 'I-kappaB kinase/NF-kappaB signaling', 'necroptotic process', 'negative regulation of apoptotic process', 'negative regulation of necroptotic process', 'negative regulation of ripoptosome assembly involved in necroptotic process', 'NIK/NF-kappaB signaling', 'placenta development', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of protein K48-linked ubiquitination', 'positive regulation of protein K63-linked ubiquitination', 'positive regulation of protein monoubiquitination', 'positive regulation of protein ubiquitination', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein polyubiquitination', 'regulation of apoptotic process', 'regulation of cell cycle', 'regulation of cell differentiation', 'regulation of cell population proliferation', 'regulation of cysteine-type endopeptidase activity', 'regulation of inflammatory response', 'regulation of innate immune response', 'regulation of necroptotic process', 'regulation of NIK/NF-kappaB signaling', 'regulation of nucleotide-binding oligomerization domain containing signaling pathway', 'regulation of reactive oxygen species metabolic process', 'regulation of RIG-I signaling pathway', 'regulation of toll-like receptor signaling pathway', 'response to cAMP', 'response to ethanol', 'response to hypoxia', 'tumor necrosis factor-mediated signaling pathway']
Histone-lysine N-methyltransferase 2C
1078
Histone-lysine N-methyltransferase 2C
1078
6.1
71
0.23
Q8NEZ4Q8NEZ4['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']
Complement C5
1159
Complement C5
1101
6.0
79
0.21
P01031P01031['cell surface receptor signaling pathway', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'G protein-coupled receptor signaling pathway', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']['cell surface receptor signaling pathway', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'G protein-coupled receptor signaling pathway', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']
Killer cell lectin-like receptor 3
154
Killer cell lectin-like receptor 3
154
6.1
80
0.2
Q61198Q61198['cell adhesion']['cell adhesion']
C-C motif chemokine 14
59
C-C motif chemokine 14
35
6.1
65
0.25
Q16627Q16627['cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']['cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']
Glucocorticoid receptor
463
Glucocorticoid receptor
463
6.1
68
0.24
P04150P04150['adrenal gland development', 'apoptotic process', 'cell cycle', 'cell division', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin organization', 'chromosome segregation', 'glucocorticoid metabolic process', 'intracellular steroid hormone receptor signaling pathway', 'mammary gland duct morphogenesis', 'maternal behavior', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'signal transduction']['adrenal gland development', 'apoptotic process', 'cell cycle', 'cell division', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin organization', 'chromosome segregation', 'glucocorticoid metabolic process', 'intracellular steroid hormone receptor signaling pathway', 'mammary gland duct morphogenesis', 'maternal behavior', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'signal transduction']
Caspase-2
320
Caspase-2
370
6.1
85
0.19
P42575P42575['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'aging', 'apoptotic process', 'apoptotic signaling pathway', 'brain development', 'cellular response to DNA damage stimulus', 'cellular response to mechanical stimulus', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'ectopic germ cell programmed cell death', 'execution phase of apoptosis', 'extrinsic apoptotic signaling pathway in absence of ligand', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'luteolysis', 'negative regulation of apoptotic process', 'negative regulation of necroptotic process', 'neural retina development', 'positive regulation of apoptotic process', 'positive regulation of apoptotic signaling pathway', 'positive regulation of neuron apoptotic process', 'protein processing', 'release of cytochrome c from mitochondria']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'aging', 'apoptotic process', 'apoptotic signaling pathway', 'brain development', 'cellular response to DNA damage stimulus', 'cellular response to mechanical stimulus', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'ectopic germ cell programmed cell death', 'execution phase of apoptosis', 'extrinsic apoptotic signaling pathway in absence of ligand', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'luteolysis', 'negative regulation of apoptotic process', 'negative regulation of necroptotic process', 'neural retina development', 'positive regulation of apoptotic process', 'positive regulation of apoptotic signaling pathway', 'positive regulation of neuron apoptotic process', 'protein processing', 'release of cytochrome c from mitochondria']
TNF receptor-associated factor 2
272
TNF receptor-associated factor 2
272
6.1
62
0.27
Q12933Q12933['activation of NF-kappaB-inducing kinase activity', 'cellular response to nitric oxide', 'interleukin-17-mediated signaling pathway', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'mRNA stabilization', 'negative regulation of glial cell apoptotic process', 'negative regulation of neuron death', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of I-kappaB phosphorylation', 'positive regulation of interleukin-2 production', 'positive regulation of JNK cascade', 'positive regulation of JUN kinase activity', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of T cell cytokine production', 'positive regulation of tumor necrosis factor-mediated signaling pathway', 'programmed necrotic cell death', 'protein autoubiquitination', 'protein catabolic process', 'protein K63-linked ubiquitination', 'protein-containing complex assembly', 'regulation of apoptotic process', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of immunoglobulin production', 'regulation of protein-containing complex assembly', 'response to endoplasmic reticulum stress', 'signal transduction', 'signal transduction involved in regulation of gene expression', 'tumor necrosis factor-mediated signaling pathway']['activation of NF-kappaB-inducing kinase activity', 'cellular response to nitric oxide', 'interleukin-17-mediated signaling pathway', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'mRNA stabilization', 'negative regulation of glial cell apoptotic process', 'negative regulation of neuron death', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of I-kappaB phosphorylation', 'positive regulation of interleukin-2 production', 'positive regulation of JNK cascade', 'positive regulation of JUN kinase activity', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of T cell cytokine production', 'positive regulation of tumor necrosis factor-mediated signaling pathway', 'programmed necrotic cell death', 'protein autoubiquitination', 'protein catabolic process', 'protein K63-linked ubiquitination', 'protein-containing complex assembly', 'regulation of apoptotic process', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of immunoglobulin production', 'regulation of protein-containing complex assembly', 'response to endoplasmic reticulum stress', 'signal transduction', 'signal transduction involved in regulation of gene expression', 'tumor necrosis factor-mediated signaling pathway']
APOBEC3H
85
APOBEC3H
85
6.1
81
0.2
B7TQM6B7TQM6[][]
Glutathione peroxidase 1
98
Glutathione peroxidase 1
98
6.2
85
0.19
P00435P00435['angiogenesis involved in wound healing', 'arachidonic acid metabolic process', 'biological process involved in interaction with symbiont', 'blood vessel endothelial cell migration', 'cell redox homeostasis', 'endothelial cell development', 'fat cell differentiation', 'fibroblast proliferation', 'glutathione metabolic process', 'heart contraction', 'hydrogen peroxide catabolic process', 'intrinsic apoptotic signaling pathway in response to oxidative stress', 'lipoxygenase pathway', 'myoblast differentiation', 'myoblast proliferation', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of inflammatory response to antigenic stimulus', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of release of cytochrome c from mitochondria', 'neuron apoptotic process', 'positive regulation of protein kinase B signaling', 'positive regulation of supramolecular fiber organization', 'protein oxidation', 'regulation of gene expression, epigenetic', 'regulation of mammary gland epithelial cell proliferation', 'regulation of proteasomal protein catabolic process', 'response to gamma radiation', 'response to hydrogen peroxide', 'response to hydroperoxide', 'response to selenium ion', 'response to symbiotic bacterium', 'response to xenobiotic stimulus', 'sensory perception of sound', 'skeletal muscle fiber development', 'skeletal muscle tissue regeneration', 'temperature homeostasis', 'triglyceride metabolic process', 'UV protection', 'vasodilation']['angiogenesis involved in wound healing', 'arachidonic acid metabolic process', 'biological process involved in interaction with symbiont', 'blood vessel endothelial cell migration', 'cell redox homeostasis', 'endothelial cell development', 'fat cell differentiation', 'fibroblast proliferation', 'glutathione metabolic process', 'heart contraction', 'hydrogen peroxide catabolic process', 'intrinsic apoptotic signaling pathway in response to oxidative stress', 'lipoxygenase pathway', 'myoblast differentiation', 'myoblast proliferation', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of inflammatory response to antigenic stimulus', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of release of cytochrome c from mitochondria', 'neuron apoptotic process', 'positive regulation of protein kinase B signaling', 'positive regulation of supramolecular fiber organization', 'protein oxidation', 'regulation of gene expression, epigenetic', 'regulation of mammary gland epithelial cell proliferation', 'regulation of proteasomal protein catabolic process', 'response to gamma radiation', 'response to hydrogen peroxide', 'response to hydroperoxide', 'response to selenium ion', 'response to symbiotic bacterium', 'response to xenobiotic stimulus', 'sensory perception of sound', 'skeletal muscle fiber development', 'skeletal muscle tissue regeneration', 'temperature homeostasis', 'triglyceride metabolic process', 'UV protection', 'vasodilation']
C-C motif chemokine 2
34
C-C motif chemokine 2
34
6.2
72
0.23
P13500P13500['angiogenesis', 'animal organ morphogenesis', 'astrocyte cell migration', 'cell adhesion', 'cell surface receptor signaling pathway', 'cellular homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to lipopolysaccharide', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'cytoskeleton organization', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'helper T cell extravasation', 'humoral immune response', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of glial cell apoptotic process', 'negative regulation of natural killer cell chemotaxis', 'negative regulation of neuron apoptotic process', 'negative regulation of vascular endothelial cell proliferation', 'neutrophil chemotaxis', 'positive regulation of apoptotic cell clearance', 'positive regulation of calcium ion import', 'positive regulation of endothelial cell apoptotic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of nitric-oxide synthase biosynthetic process', 'positive regulation of NMDA glutamate receptor activity', 'positive regulation of synaptic transmission, glutamatergic', 'positive regulation of T cell activation', 'protein kinase B signaling', 'protein phosphorylation', 'receptor signaling pathway via JAK-STAT', 'regulation of cell shape', 'response to bacterium', 'sensory perception of pain', 'signal transduction', 'viral genome replication']['angiogenesis', 'animal organ morphogenesis', 'astrocyte cell migration', 'cell adhesion', 'cell surface receptor signaling pathway', 'cellular homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to lipopolysaccharide', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'cytoskeleton organization', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'helper T cell extravasation', 'humoral immune response', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of glial cell apoptotic process', 'negative regulation of natural killer cell chemotaxis', 'negative regulation of neuron apoptotic process', 'negative regulation of vascular endothelial cell proliferation', 'neutrophil chemotaxis', 'positive regulation of apoptotic cell clearance', 'positive regulation of calcium ion import', 'positive regulation of endothelial cell apoptotic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of nitric-oxide synthase biosynthetic process', 'positive regulation of NMDA glutamate receptor activity', 'positive regulation of synaptic transmission, glutamatergic', 'positive regulation of T cell activation', 'protein kinase B signaling', 'protein phosphorylation', 'receptor signaling pathway via JAK-STAT', 'regulation of cell shape', 'response to bacterium', 'sensory perception of pain', 'signal transduction', 'viral genome replication']
Kelch-like ECH-associated protein 1
434
Kelch-like ECH-associated protein 1
395
6.6
61
0.25
Q14145Q14145['cellular response to interleukin-4', 'cellular response to oxidative stress', 'cytoplasmic sequestering of transcription factor', 'in utero embryonic development', 'negative regulation of DNA-binding transcription factor activity', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'protein ubiquitination', 'regulation of autophagy', 'regulation of epidermal cell differentiation', 'ubiquitin-dependent protein catabolic process']['cellular response to interleukin-4', 'cellular response to oxidative stress', 'cytoplasmic sequestering of transcription factor', 'in utero embryonic development', 'negative regulation of DNA-binding transcription factor activity', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'protein ubiquitination', 'regulation of autophagy', 'regulation of epidermal cell differentiation', 'ubiquitin-dependent protein catabolic process']
Histone H3.3C
110
Histone H3.3C
110
6.4
84
0.19
Q6NXT2Q6NXT2['positive regulation of cell growth']['positive regulation of cell growth']
DNA (cytosine-5)-methyltransferase 3A
540
DNA (cytosine-5)-methyltransferase 3A
514
6.4
89
0.18
Q9Y6K1Q9Y6K1['aging', 'C-5 methylation of cytosine', 'cellular response to amino acid stimulus', 'cellular response to bisphenol A', 'cellular response to ethanol', 'cellular response to hypoxia', 'DNA methylation', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'DNA methylation on cytosine', 'DNA methylation-dependent heterochromatin assembly', 'hepatocyte apoptotic process', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron differentiation', 'positive regulation of cell death', 'regulation of gene expression by genomic imprinting', 'response to cocaine', 'response to estradiol', 'response to ionizing radiation', 'response to lead ion', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'spermatogenesis']['aging', 'C-5 methylation of cytosine', 'cellular response to amino acid stimulus', 'cellular response to bisphenol A', 'cellular response to ethanol', 'cellular response to hypoxia', 'DNA methylation', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'DNA methylation on cytosine', 'DNA methylation-dependent heterochromatin assembly', 'hepatocyte apoptotic process', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron differentiation', 'positive regulation of cell death', 'regulation of gene expression by genomic imprinting', 'response to cocaine', 'response to estradiol', 'response to ionizing radiation', 'response to lead ion', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'spermatogenesis']
Protein arginine N-methyltransferase 8
273
Protein arginine N-methyltransferase 8
295
6.4
81
0.19
Q9NR22Q9NR22['histone methylation', 'peptidyl-arginine methylation', 'peptidyl-arginine methylation, to asymmetrical-dimethyl arginine', 'protein homooligomerization', 'protein methylation', 'regulation of protein binding']['histone methylation', 'peptidyl-arginine methylation', 'peptidyl-arginine methylation, to asymmetrical-dimethyl arginine', 'protein homooligomerization', 'protein methylation', 'regulation of protein binding']
Heat shock protein beta-1
137
Heat shock protein beta-1
137
6.4
66
0.24
P04792P04792['anterograde axonal protein transport', 'cellular response to vascular endothelial growth factor stimulus', 'chaperone-mediated protein folding', 'intracellular signal transduction', 'negative regulation of apoptotic process', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein kinase activity', 'platelet aggregation', 'positive regulation of angiogenesis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of endothelial cell chemotaxis', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of interleukin-1 beta production', 'positive regulation of tumor necrosis factor production', 'protein refolding', 'regulation of autophagy', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of protein phosphorylation', 'regulation of translational initiation', 'response to heat', 'response to unfolded protein', 'response to virus', 'retina homeostasis']['anterograde axonal protein transport', 'cellular response to vascular endothelial growth factor stimulus', 'chaperone-mediated protein folding', 'intracellular signal transduction', 'negative regulation of apoptotic process', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein kinase activity', 'platelet aggregation', 'positive regulation of angiogenesis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of endothelial cell chemotaxis', 'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway', 'positive regulation of interleukin-1 beta production', 'positive regulation of tumor necrosis factor production', 'protein refolding', 'regulation of autophagy', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of protein phosphorylation', 'regulation of translational initiation', 'response to heat', 'response to unfolded protein', 'response to virus', 'retina homeostasis']
G-protein-signaling modulator 2
614
G-protein-signaling modulator 2
125
6.4
89
0.17
Q8VDU0Q8VDU0['cell division', 'establishment of mitotic spindle orientation', 'maintenance of centrosome location', 'mitotic spindle organization', 'positive regulation of protein localization to cell cortex', 'positive regulation of spindle assembly', 'Ran protein signal transduction', 'regulation of mitotic spindle organization']['cell division', 'establishment of mitotic spindle orientation', 'maintenance of centrosome location', 'mitotic spindle organization', 'positive regulation of protein localization to cell cortex', 'positive regulation of spindle assembly', 'Ran protein signal transduction', 'regulation of mitotic spindle organization']
Proproteinase E
227
Proproteinase E
227
6.4
96
0.16
P05805P05805['digestion', 'proteolysis']['digestion', 'proteolysis']
Myosin-7
1748
Myosin-7
1748
6.4
92
0.17
P12883P12883['adult heart development', 'ATP metabolic process', 'cardiac muscle contraction', 'cardiac muscle hypertrophy in response to stress', 'muscle contraction', 'muscle filament sliding', 'regulation of heart rate', 'regulation of slow-twitch skeletal muscle fiber contraction', 'regulation of the force of heart contraction', 'regulation of the force of skeletal muscle contraction', 'sarcomere organization', 'skeletal muscle contraction', 'striated muscle contraction', 'transition between fast and slow fiber', 'ventricular cardiac muscle tissue morphogenesis']['adult heart development', 'ATP metabolic process', 'cardiac muscle contraction', 'cardiac muscle hypertrophy in response to stress', 'muscle contraction', 'muscle filament sliding', 'regulation of heart rate', 'regulation of slow-twitch skeletal muscle fiber contraction', 'regulation of the force of heart contraction', 'regulation of the force of skeletal muscle contraction', 'sarcomere organization', 'skeletal muscle contraction', 'striated muscle contraction', 'transition between fast and slow fiber', 'ventricular cardiac muscle tissue morphogenesis']
TNF receptor-associated factor 2
303
TNF receptor-associated factor 2
303
6.4
67
0.23
Q12933Q12933['activation of NF-kappaB-inducing kinase activity', 'cellular response to nitric oxide', 'interleukin-17-mediated signaling pathway', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'mRNA stabilization', 'negative regulation of glial cell apoptotic process', 'negative regulation of neuron death', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of I-kappaB phosphorylation', 'positive regulation of interleukin-2 production', 'positive regulation of JNK cascade', 'positive regulation of JUN kinase activity', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of T cell cytokine production', 'positive regulation of tumor necrosis factor-mediated signaling pathway', 'programmed necrotic cell death', 'protein autoubiquitination', 'protein catabolic process', 'protein K63-linked ubiquitination', 'protein-containing complex assembly', 'regulation of apoptotic process', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of immunoglobulin production', 'regulation of protein-containing complex assembly', 'response to endoplasmic reticulum stress', 'signal transduction', 'signal transduction involved in regulation of gene expression', 'tumor necrosis factor-mediated signaling pathway']['activation of NF-kappaB-inducing kinase activity', 'cellular response to nitric oxide', 'interleukin-17-mediated signaling pathway', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'mRNA stabilization', 'negative regulation of glial cell apoptotic process', 'negative regulation of neuron death', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of I-kappaB phosphorylation', 'positive regulation of interleukin-2 production', 'positive regulation of JNK cascade', 'positive regulation of JUN kinase activity', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of T cell cytokine production', 'positive regulation of tumor necrosis factor-mediated signaling pathway', 'programmed necrotic cell death', 'protein autoubiquitination', 'protein catabolic process', 'protein K63-linked ubiquitination', 'protein-containing complex assembly', 'regulation of apoptotic process', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of immunoglobulin production', 'regulation of protein-containing complex assembly', 'response to endoplasmic reticulum stress', 'signal transduction', 'signal transduction involved in regulation of gene expression', 'tumor necrosis factor-mediated signaling pathway']
4-aminobutyrate aminotransferase, mitochondrial
163
4-aminobutyrate aminotransferase, mitochondrial
163
6.5
90
0.17
P80147P80147['behavioral response to cocaine', 'gamma-aminobutyric acid catabolic process', 'neurotransmitter catabolic process']['behavioral response to cocaine', 'gamma-aminobutyric acid catabolic process', 'neurotransmitter catabolic process']
DNA polymerase alpha subunit B
392
DNA polymerase alpha catalytic subunit
1281
6.5
65
0.24
Q14181P09884['DNA replication', 'DNA replication initiation', 'DNA replication, synthesis of RNA primer', 'protein import into nucleus']['DNA repair', 'DNA replication', 'DNA replication initiation', 'DNA replication, synthesis of RNA primer', 'DNA strand elongation involved in DNA replication', 'DNA synthesis involved in DNA repair', 'double-strand break repair via nonhomologous end joining', 'lagging strand elongation', 'leading strand elongation', 'mitotic DNA replication initiation', 'regulation of type I interferon production']
Glutamine synthetase
42
Glutamine synthetase
163
6.5
81
0.19
P15104P15104['ammonia assimilation cycle', 'angiogenesis', 'cell population proliferation', 'cellular response to starvation', 'glutamate catabolic process', 'glutamine biosynthetic process', 'positive regulation of epithelial cell proliferation', 'positive regulation of insulin secretion', 'positive regulation of synaptic transmission, glutamatergic', 'protein palmitoylation', 'regulation of endothelial cell migration', 'regulation of protein localization to nucleolus', 'regulation of sprouting angiogenesis', 'response to glucose', 'ribosome biogenesis']['ammonia assimilation cycle', 'angiogenesis', 'cell population proliferation', 'cellular response to starvation', 'glutamate catabolic process', 'glutamine biosynthetic process', 'positive regulation of epithelial cell proliferation', 'positive regulation of insulin secretion', 'positive regulation of synaptic transmission, glutamatergic', 'protein palmitoylation', 'regulation of endothelial cell migration', 'regulation of protein localization to nucleolus', 'regulation of sprouting angiogenesis', 'response to glucose', 'ribosome biogenesis']
C-C motif chemokine 4
58
C-C motif chemokine 4
34
6.5
70
0.22
P13236P13236['cell adhesion', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'eosinophil chemotaxis', 'establishment or maintenance of cell polarity', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'neutrophil chemotaxis', 'positive regulation of calcium ion transport', 'positive regulation of calcium-mediated signaling', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of natural killer cell chemotaxis', 'response to toxic substance', 'response to virus', 'signal transduction']['cell adhesion', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'eosinophil chemotaxis', 'establishment or maintenance of cell polarity', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'neutrophil chemotaxis', 'positive regulation of calcium ion transport', 'positive regulation of calcium-mediated signaling', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of natural killer cell chemotaxis', 'response to toxic substance', 'response to virus', 'signal transduction']
Speckle targeted PIP5K1A-regulated poly(A) polymerase
351
Speckle targeted PIP5K1A-regulated poly(A) polymerase
351
6.5
65
0.24
Q9H6E5Q9H6E5['mRNA polyadenylation', 'pre-mRNA cleavage required for polyadenylation', "RNA 3'-end processing", 'snRNA processing', "U6 snRNA 3'-end processing"]['mRNA polyadenylation', 'pre-mRNA cleavage required for polyadenylation', "RNA 3'-end processing", 'snRNA processing', "U6 snRNA 3'-end processing"]
Baculoviral IAP repeat-containing protein 2
315
Baculoviral IAP repeat-containing protein 2
315
6.5
41
0.38
Q13490Q13490['cell surface receptor signaling pathway', 'I-kappaB kinase/NF-kappaB signaling', 'necroptotic process', 'negative regulation of apoptotic process', 'negative regulation of necroptotic process', 'negative regulation of ripoptosome assembly involved in necroptotic process', 'NIK/NF-kappaB signaling', 'placenta development', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of protein K48-linked ubiquitination', 'positive regulation of protein K63-linked ubiquitination', 'positive regulation of protein monoubiquitination', 'positive regulation of protein ubiquitination', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein polyubiquitination', 'regulation of apoptotic process', 'regulation of cell cycle', 'regulation of cell differentiation', 'regulation of cell population proliferation', 'regulation of cysteine-type endopeptidase activity', 'regulation of inflammatory response', 'regulation of innate immune response', 'regulation of necroptotic process', 'regulation of NIK/NF-kappaB signaling', 'regulation of nucleotide-binding oligomerization domain containing signaling pathway', 'regulation of reactive oxygen species metabolic process', 'regulation of RIG-I signaling pathway', 'regulation of toll-like receptor signaling pathway', 'response to cAMP', 'response to ethanol', 'response to hypoxia', 'tumor necrosis factor-mediated signaling pathway']['cell surface receptor signaling pathway', 'I-kappaB kinase/NF-kappaB signaling', 'necroptotic process', 'negative regulation of apoptotic process', 'negative regulation of necroptotic process', 'negative regulation of ripoptosome assembly involved in necroptotic process', 'NIK/NF-kappaB signaling', 'placenta development', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of protein K48-linked ubiquitination', 'positive regulation of protein K63-linked ubiquitination', 'positive regulation of protein monoubiquitination', 'positive regulation of protein ubiquitination', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein polyubiquitination', 'regulation of apoptotic process', 'regulation of cell cycle', 'regulation of cell differentiation', 'regulation of cell population proliferation', 'regulation of cysteine-type endopeptidase activity', 'regulation of inflammatory response', 'regulation of innate immune response', 'regulation of necroptotic process', 'regulation of NIK/NF-kappaB signaling', 'regulation of nucleotide-binding oligomerization domain containing signaling pathway', 'regulation of reactive oxygen species metabolic process', 'regulation of RIG-I signaling pathway', 'regulation of toll-like receptor signaling pathway', 'response to cAMP', 'response to ethanol', 'response to hypoxia', 'tumor necrosis factor-mediated signaling pathway']
Adrenodoxin, mitochondrial
110
Adrenodoxin, mitochondrial
110
6.5
93
0.17
P00257P00257['cellular response to cAMP', 'cellular response to forskolin', 'cholesterol metabolic process', 'electron transport chain', 'hormone biosynthetic process', 'P450-containing electron transport chain', 'positive regulation of oxidoreductase activity', 'respiratory electron transport chain', 'steroid biosynthetic process']['cellular response to cAMP', 'cellular response to forskolin', 'cholesterol metabolic process', 'electron transport chain', 'hormone biosynthetic process', 'P450-containing electron transport chain', 'positive regulation of oxidoreductase activity', 'respiratory electron transport chain', 'steroid biosynthetic process']
N-lysine methyltransferase KMT5A
311
N-lysine methyltransferase KMT5A
311
6.5
62
0.25
Q9NQR1Q9NQR1['cell division', 'chromatin organization', 'histone H4-K20 monomethylation', 'mitotic chromosome condensation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'peptidyl-lysine monomethylation', 'regulation of DNA damage response, signal transduction by p53 class mediator', 'regulation of signal transduction by p53 class mediator', 'regulation of transcription by RNA polymerase II']['cell division', 'chromatin organization', 'histone H4-K20 monomethylation', 'mitotic chromosome condensation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'peptidyl-lysine monomethylation', 'regulation of DNA damage response, signal transduction by p53 class mediator', 'regulation of signal transduction by p53 class mediator', 'regulation of transcription by RNA polymerase II']
Uromodulin
425
Uromodulin
335
6.5
87
0.18
P07911P07911['apoptotic signaling pathway', 'autophagy', 'cellular calcium ion homeostasis', 'cellular chloride ion homeostasis', 'cellular defense response', 'cellular phosphate ion homeostasis', 'cellular response to unfolded protein', 'cellular sodium ion homeostasis', 'chaperone-mediated protein folding', 'citric acid secretion', 'collecting duct development', 'connective tissue replacement', 'creatinine homeostasis', 'defense response to Gram-negative bacterium', 'endoplasmic reticulum organization', 'glomerular filtration', 'heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules', 'inflammatory response', 'juxtaglomerular apparatus development', 'leukocyte cell-cell adhesion', 'lipid metabolic process', 'metanephric ascending thin limb development', 'metanephric distal convoluted tubule development', 'metanephric thick ascending limb development', 'micturition', 'multicellular organismal response to stress', 'negative regulation of cell population proliferation', 'neutrophil migration', 'organ or tissue specific immune response', 'peptidyl-threonine phosphorylation', 'potassium ion homeostasis', 'protein localization to vacuole', 'protein transport into plasma membrane raft', 'regulation of blood pressure', 'regulation of protein transport', 'regulation of urine volume', 'renal sodium ion absorption', 'renal urate salt excretion', 'renal water homeostasis', 'response to lipopolysaccharide', 'response to water deprivation', 'response to xenobiotic stimulus', 'RNA splicing', 'tumor necrosis factor-mediated signaling pathway', 'ubiquitin-dependent ERAD pathway', 'urate transport', 'urea transmembrane transport']['apoptotic signaling pathway', 'autophagy', 'cellular calcium ion homeostasis', 'cellular chloride ion homeostasis', 'cellular defense response', 'cellular phosphate ion homeostasis', 'cellular response to unfolded protein', 'cellular sodium ion homeostasis', 'chaperone-mediated protein folding', 'citric acid secretion', 'collecting duct development', 'connective tissue replacement', 'creatinine homeostasis', 'defense response to Gram-negative bacterium', 'endoplasmic reticulum organization', 'glomerular filtration', 'heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules', 'inflammatory response', 'juxtaglomerular apparatus development', 'leukocyte cell-cell adhesion', 'lipid metabolic process', 'metanephric ascending thin limb development', 'metanephric distal convoluted tubule development', 'metanephric thick ascending limb development', 'micturition', 'multicellular organismal response to stress', 'negative regulation of cell population proliferation', 'neutrophil migration', 'organ or tissue specific immune response', 'peptidyl-threonine phosphorylation', 'potassium ion homeostasis', 'protein localization to vacuole', 'protein transport into plasma membrane raft', 'regulation of blood pressure', 'regulation of protein transport', 'regulation of urine volume', 'renal sodium ion absorption', 'renal urate salt excretion', 'renal water homeostasis', 'response to lipopolysaccharide', 'response to water deprivation', 'response to xenobiotic stimulus', 'RNA splicing', 'tumor necrosis factor-mediated signaling pathway', 'ubiquitin-dependent ERAD pathway', 'urate transport', 'urea transmembrane transport']
Exportin-1
723
Snurportin-1
356
6.5
61
0.25
Q6P5F9O95149['mRNA transport', 'negative regulation of transcription by RNA polymerase II', 'nucleocytoplasmic transport', 'protein export from nucleus', 'protein localization to nucleus', 'regulation of centrosome duplication', 'regulation of proteasomal ubiquitin-dependent protein catabolic process', 'regulation of protein catabolic process', 'regulation of protein export from nucleus', 'ribosomal large subunit export from nucleus', 'ribosomal small subunit export from nucleus', 'ribosomal subunit export from nucleus', 'ribosome biogenesis']['protein import into nucleus', 'RNA import into nucleus', 'snRNA import into nucleus']
Proteasome subunit beta type-7
74
Proteasome subunit beta type-3
129
6.5
73
0.21
Q99436P49720['proteasomal protein catabolic process', 'proteasome-mediated ubiquitin-dependent protein catabolic process']['proteasomal protein catabolic process', 'proteasome-mediated ubiquitin-dependent protein catabolic process']
4-aminobutyrate aminotransferase, mitochondrial
166
4-aminobutyrate aminotransferase, mitochondrial
166
6.7
104
0.14
P80147P80147['behavioral response to cocaine', 'gamma-aminobutyric acid catabolic process', 'neurotransmitter catabolic process']['behavioral response to cocaine', 'gamma-aminobutyric acid catabolic process', 'neurotransmitter catabolic process']
Nitric-oxide synthase (NADPH)
382
Nitric-oxide synthase (NADPH)
382
6.7
70
0.21
A0S0A6A0S0A6['nitric oxide biosynthetic process']['nitric oxide biosynthetic process']
Serine protease 1
132
Serine protease 1
132
6.6
73
0.21
P00760P00760['digestion', 'proteolysis']['digestion', 'proteolysis']
Complement C5
1101
Complement C5
1101
6.4
80
0.19
P01031P01031['cell surface receptor signaling pathway', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'G protein-coupled receptor signaling pathway', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']['cell surface receptor signaling pathway', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'G protein-coupled receptor signaling pathway', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']
ADP-ribosylation factor-binding protein GGA1
77
ADP-ribosylation factor-binding protein GGA1
73
6.7
75
0.2
Q9UJY5Q9UJY5['Golgi to plasma membrane protein transport', 'Golgi to plasma membrane transport', 'intracellular protein transport', 'positive regulation of protein catabolic process', 'protein catabolic process', 'protein localization', 'protein localization to cell surface', 'protein localization to ciliary membrane', 'retrograde transport, endosome to Golgi', 'toxin transport']['Golgi to plasma membrane protein transport', 'Golgi to plasma membrane transport', 'intracellular protein transport', 'positive regulation of protein catabolic process', 'protein catabolic process', 'protein localization', 'protein localization to cell surface', 'protein localization to ciliary membrane', 'retrograde transport, endosome to Golgi', 'toxin transport']
Androgen receptor
584
Androgen receptor
584
6.7
68
0.22
P15207P15207['activation of prostate induction by androgen receptor signaling pathway', 'androgen receptor signaling pathway', 'animal organ formation', 'cellular response to estrogen stimulus', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to testosterone stimulus', 'copulation', 'epithelial cell differentiation involved in prostate gland development', 'epithelial cell morphogenesis', 'fertilization', 'in utero embryonic development', 'intracellular estrogen receptor signaling pathway', 'intracellular receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lateral sprouting involved in mammary gland duct morphogenesis', 'Leydig cell differentiation', 'male courtship behavior', 'male genitalia morphogenesis', 'male gonad development', 'male sex differentiation', 'male somatic sex determination', 'mammary gland alveolus development', 'morphogenesis of an epithelial fold', 'multicellular organism growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of integrin biosynthetic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell proliferation involved in prostate gland development', 'positive regulation of gene expression', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of integrin biosynthetic process', 'positive regulation of intracellular estrogen receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of penile erection', 'positive regulation of phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase III', 'positive regulation of transcription, DNA-templated', 'prostate gland epithelium morphogenesis', 'prostate gland growth', 'regulation of developmental growth', 'regulation of gene expression', 'regulation of prostatic bud formation', 'regulation of protein localization to plasma membrane', 'regulation of systemic arterial blood pressure', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'reproductive behavior', 'reproductive structure development', 'reproductive system development', 'response to estradiol', 'response to insulin', 'response to testosterone', 'seminiferous tubule development', 'single fertilization', 'skeletal muscle hypertrophy', 'spermatogenesis', 'tertiary branching involved in mammary gland duct morphogenesis']['activation of prostate induction by androgen receptor signaling pathway', 'androgen receptor signaling pathway', 'animal organ formation', 'cellular response to estrogen stimulus', 'cellular response to follicle-stimulating hormone stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to testosterone stimulus', 'copulation', 'epithelial cell differentiation involved in prostate gland development', 'epithelial cell morphogenesis', 'fertilization', 'in utero embryonic development', 'intracellular estrogen receptor signaling pathway', 'intracellular receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lateral sprouting involved in mammary gland duct morphogenesis', 'Leydig cell differentiation', 'male courtship behavior', 'male genitalia morphogenesis', 'male gonad development', 'male sex differentiation', 'male somatic sex determination', 'mammary gland alveolus development', 'morphogenesis of an epithelial fold', 'multicellular organism growth', 'negative regulation of cell population proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of integrin biosynthetic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell proliferation involved in prostate gland development', 'positive regulation of gene expression', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of integrin biosynthetic process', 'positive regulation of intracellular estrogen receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of penile erection', 'positive regulation of phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase III', 'positive regulation of transcription, DNA-templated', 'prostate gland epithelium morphogenesis', 'prostate gland growth', 'regulation of developmental growth', 'regulation of gene expression', 'regulation of prostatic bud formation', 'regulation of protein localization to plasma membrane', 'regulation of systemic arterial blood pressure', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'reproductive behavior', 'reproductive structure development', 'reproductive system development', 'response to estradiol', 'response to insulin', 'response to testosterone', 'seminiferous tubule development', 'single fertilization', 'skeletal muscle hypertrophy', 'spermatogenesis', 'tertiary branching involved in mammary gland duct morphogenesis']
Transforming growth factor beta-1 proprotein
225
Transforming growth factor beta-1 proprotein
225
6.7
64
0.23
P07200P07200['adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains', 'aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'branch elongation involved in mammary gland duct branching', 'bronchiole development', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'cellular calcium ion homeostasis', 'cellular response to ionizing radiation', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'chondrocyte differentiation', 'columnar/cuboidal epithelial cell maturation', 'common-partner SMAD protein phosphorylation', 'embryonic liver development', 'enamel mineralization', 'endoderm development', 'epidermal growth factor receptor signaling pathway', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'face morphogenesis', 'gene expression', 'germ cell migration', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'Langerhans cell differentiation', 'lens fiber cell differentiation', 'lipopolysaccharide-mediated signaling pathway', 'lung alveolus development', 'lymph node development', 'mammary gland branching involved in thelarche', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'muscle cell cellular homeostasis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of epithelial cell proliferation', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of interleukin-17 production', 'negative regulation of macrophage cytokine production', 'negative regulation of myoblast differentiation', 'negative regulation of ossification', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of T cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'Notch signaling pathway', 'oligodendrocyte development', 'ossification involved in bone remodeling', 'osteoclast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'phospholipid homeostasis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of histone acetylation', 'positive regulation of histone deacetylation', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of odontogenesis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor clustering', 'positive regulation of regulatory T cell differentiation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stem cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of actin cytoskeleton reorganization', 'regulation of binding', 'regulation of branching involved in mammary gland duct morphogenesis', 'regulation of cartilage development', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of interleukin-23 production', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of sodium ion transport', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulatory T cell differentiation', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'stem cell proliferation', 'surfactant homeostasis', 'T cell homeostasis', 'T cell proliferation', 'tolerance induction to self antigen', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'ureteric bud development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains', 'aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'branch elongation involved in mammary gland duct branching', 'bronchiole development', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'cellular calcium ion homeostasis', 'cellular response to ionizing radiation', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'chondrocyte differentiation', 'columnar/cuboidal epithelial cell maturation', 'common-partner SMAD protein phosphorylation', 'embryonic liver development', 'enamel mineralization', 'endoderm development', 'epidermal growth factor receptor signaling pathway', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'face morphogenesis', 'gene expression', 'germ cell migration', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'Langerhans cell differentiation', 'lens fiber cell differentiation', 'lipopolysaccharide-mediated signaling pathway', 'lung alveolus development', 'lymph node development', 'mammary gland branching involved in thelarche', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'muscle cell cellular homeostasis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of epithelial cell proliferation', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of interleukin-17 production', 'negative regulation of macrophage cytokine production', 'negative regulation of myoblast differentiation', 'negative regulation of ossification', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of T cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'Notch signaling pathway', 'oligodendrocyte development', 'ossification involved in bone remodeling', 'osteoclast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'phospholipid homeostasis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of histone acetylation', 'positive regulation of histone deacetylation', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of odontogenesis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor clustering', 'positive regulation of regulatory T cell differentiation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stem cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of actin cytoskeleton reorganization', 'regulation of binding', 'regulation of branching involved in mammary gland duct morphogenesis', 'regulation of cartilage development', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of interleukin-23 production', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of sodium ion transport', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulatory T cell differentiation', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'stem cell proliferation', 'surfactant homeostasis', 'T cell homeostasis', 'T cell proliferation', 'tolerance induction to self antigen', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'ureteric bud development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']
Histone H3.1t
111
Histone H3.1t
111
6.6
86
0.18
Q16695Q16695['nucleosome assembly']['nucleosome assembly']
Calcium/calmodulin-dependent protein kinase type II subunit alpha
428
Calcium/calmodulin-dependent protein kinase type II subunit alpha
428
7.0
97
0.15
Q9UQM7Q9UQM7['angiotensin-activated signaling pathway', 'calcium ion transport', 'dendritic spine development', 'G1/S transition of mitotic cell cycle', 'negative regulation of hydrolase activity', 'peptidyl-serine phosphorylation', 'peptidyl-threonine autophosphorylation', 'positive regulation of calcium ion transport', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of NF-kappaB transcription factor activity', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of endocannabinoid signaling pathway', 'regulation of mitochondrial membrane permeability involved in apoptotic process', 'regulation of neuron migration', 'regulation of neuronal synaptic plasticity', 'regulation of neurotransmitter secretion', 'response to ischemia']['angiotensin-activated signaling pathway', 'calcium ion transport', 'dendritic spine development', 'G1/S transition of mitotic cell cycle', 'negative regulation of hydrolase activity', 'peptidyl-serine phosphorylation', 'peptidyl-threonine autophosphorylation', 'positive regulation of calcium ion transport', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of NF-kappaB transcription factor activity', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of endocannabinoid signaling pathway', 'regulation of mitochondrial membrane permeability involved in apoptotic process', 'regulation of neuron migration', 'regulation of neuronal synaptic plasticity', 'regulation of neurotransmitter secretion', 'response to ischemia']
Acetyl-coenzyme A thioesterase
270
Acetyl-coenzyme A thioesterase
51
7.0
76
0.19
Q8WYK0Q8WYK0['acetyl-CoA metabolic process', 'acyl-CoA metabolic process', 'fatty acid metabolic process']['acetyl-CoA metabolic process', 'acyl-CoA metabolic process', 'fatty acid metabolic process']
Protein cereblon
329
Protein cereblon
397
7.0
65
0.22
Q8C7D2Q8C7D2['locomotory exploration behavior', 'negative regulation of ion transmembrane transport', 'negative regulation of large conductance calcium-activated potassium channel activity', 'negative regulation of protein-containing complex assembly', 'positive regulation of protein-containing complex assembly', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination']['locomotory exploration behavior', 'negative regulation of ion transmembrane transport', 'negative regulation of large conductance calcium-activated potassium channel activity', 'negative regulation of protein-containing complex assembly', 'positive regulation of protein-containing complex assembly', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination']
Malonyl-CoA decarboxylase, mitochondrial
243
Malonyl-CoA decarboxylase, mitochondrial
243
7.0
61
0.23
1
✔O95822O95822['acetyl-CoA biosynthetic process', 'acyl-CoA metabolic process', 'fatty acid biosynthetic process', 'fatty acid oxidation', 'malonyl-CoA catabolic process', 'positive regulation of fatty acid oxidation', 'regulation of fatty acid beta-oxidation', 'regulation of glucose metabolic process', 'response to ischemia']['acetyl-CoA biosynthetic process', 'acyl-CoA metabolic process', 'fatty acid biosynthetic process', 'fatty acid oxidation', 'malonyl-CoA catabolic process', 'positive regulation of fatty acid oxidation', 'regulation of fatty acid beta-oxidation', 'regulation of glucose metabolic process', 'response to ischemia']
Nitric oxide synthase, endothelial
382
Nitric oxide synthase, endothelial
382
7.0
72
0.2
P29474P29474['angiogenesis', 'aortic valve morphogenesis', 'arginine catabolic process', 'blood vessel diameter maintenance', 'blood vessel remodeling', 'calcium ion transport', 'cell redox homeostasis', 'endocardial cushion morphogenesis', 'endothelial cell migration', 'establishment of localization in cell', 'homeostasis of number of cells within a tissue', 'in utero embryonic development', 'lipopolysaccharide-mediated signaling pathway', 'lung development', 'mitochondrion organization', 'negative regulation of biomineral tissue development', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of cell population proliferation', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrolase activity', 'negative regulation of muscle hyperplasia', 'negative regulation of platelet activation', 'negative regulation of potassium ion transport', 'negative regulation of smooth muscle cell proliferation', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'ovulation from ovarian follicle', 'positive regulation of angiogenesis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of gene expression', 'positive regulation of guanylate cyclase activity', 'positive regulation of Notch signaling pathway', 'potassium ion transport', 'pulmonary valve morphogenesis', 'regulation of blood pressure', 'regulation of nervous system process', 'regulation of sodium ion transport', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of the force of heart contraction by chemical signal', 'removal of superoxide radicals', 'response to fluid shear stress', 'response to heat', 'response to hormone', 'response to lipopolysaccharide', 'smooth muscle hyperplasia', 'vasodilation', 'ventricular septum morphogenesis']['angiogenesis', 'aortic valve morphogenesis', 'arginine catabolic process', 'blood vessel diameter maintenance', 'blood vessel remodeling', 'calcium ion transport', 'cell redox homeostasis', 'endocardial cushion morphogenesis', 'endothelial cell migration', 'establishment of localization in cell', 'homeostasis of number of cells within a tissue', 'in utero embryonic development', 'lipopolysaccharide-mediated signaling pathway', 'lung development', 'mitochondrion organization', 'negative regulation of biomineral tissue development', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of cell population proliferation', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrolase activity', 'negative regulation of muscle hyperplasia', 'negative regulation of platelet activation', 'negative regulation of potassium ion transport', 'negative regulation of smooth muscle cell proliferation', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'ovulation from ovarian follicle', 'positive regulation of angiogenesis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of gene expression', 'positive regulation of guanylate cyclase activity', 'positive regulation of Notch signaling pathway', 'potassium ion transport', 'pulmonary valve morphogenesis', 'regulation of blood pressure', 'regulation of nervous system process', 'regulation of sodium ion transport', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of the force of heart contraction by chemical signal', 'removal of superoxide radicals', 'response to fluid shear stress', 'response to heat', 'response to hormone', 'response to lipopolysaccharide', 'smooth muscle hyperplasia', 'vasodilation', 'ventricular septum morphogenesis']
Kinesin-like protein KIF21A
1006
Kinesin-like protein KIF21A
1006
7.0
73
0.19
Q7Z4S6Q7Z4S6['microtubule-based movement']['microtubule-based movement']
Glucocorticoid receptor
476
Glucocorticoid receptor
482
7.1
66
0.21
P06536P06536['adrenal gland development', 'aging', 'androgen metabolic process', 'brain development', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to magnesium ion', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin remodeling', 'circadian rhythm', 'epigenetic maintenance of chromatin in transcription-competent conformation', 'female pregnancy', 'glucocorticoid metabolic process', 'glucocorticoid receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lung development', 'mammary gland duct morphogenesis', 'maternal behavior', 'muscle atrophy', 'negative regulation of apoptotic process', 'negative regulation of synaptic plasticity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular permeability', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of dendritic spine development', 'positive regulation of glucocorticoid receptor signaling pathway', 'positive regulation of glutamate secretion', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'protein-containing complex assembly', 'regulation of cell population proliferation', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of glucose metabolic process', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to activity', 'response to arsenic-containing substance', 'response to calcium ion', 'response to corticosterone', 'response to dexamethasone', 'response to electrical stimulus', 'response to inactivity', 'response to insulin', 'response to mercury ion', 'response to radiation']['adrenal gland development', 'aging', 'androgen metabolic process', 'brain development', 'cellular response to dexamethasone stimulus', 'cellular response to glucocorticoid stimulus', 'cellular response to magnesium ion', 'cellular response to steroid hormone stimulus', 'cellular response to transforming growth factor beta stimulus', 'chromatin remodeling', 'circadian rhythm', 'epigenetic maintenance of chromatin in transcription-competent conformation', 'female pregnancy', 'glucocorticoid metabolic process', 'glucocorticoid receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'lung development', 'mammary gland duct morphogenesis', 'maternal behavior', 'muscle atrophy', 'negative regulation of apoptotic process', 'negative regulation of synaptic plasticity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of vascular permeability', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of dendritic spine development', 'positive regulation of glucocorticoid receptor signaling pathway', 'positive regulation of glutamate secretion', 'positive regulation of miRNA transcription', 'positive regulation of neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'protein-containing complex assembly', 'regulation of cell population proliferation', 'regulation of glucocorticoid biosynthetic process', 'regulation of gluconeogenesis', 'regulation of glucose metabolic process', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to activity', 'response to arsenic-containing substance', 'response to calcium ion', 'response to corticosterone', 'response to dexamethasone', 'response to electrical stimulus', 'response to inactivity', 'response to insulin', 'response to mercury ion', 'response to radiation']
C-C motif chemokine 16
37
C-C motif chemokine 16
60
7.1
64
0.22
O15467O15467['cell communication', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']['cell communication', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']
SPARC
95
SPARC
95
7.1
82
0.17
P09486P09486['anatomical structure development', 'negative regulation of angiogenesis', 'negative regulation of endothelial cell proliferation', 'positive regulation of endothelial cell migration', 'regulation of cell morphogenesis']['anatomical structure development', 'negative regulation of angiogenesis', 'negative regulation of endothelial cell proliferation', 'positive regulation of endothelial cell migration', 'regulation of cell morphogenesis']
Protein PML
72
Protein PML
72
7.0
67
0.21
P29590P29590['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'apoptotic process', 'branching involved in mammary gland duct morphogenesis', 'cell fate commitment', 'cellular response to interleukin-4', 'cellular response to leukemia inhibitory factor', 'cellular senescence', 'circadian regulation of gene expression', 'common-partner SMAD protein phosphorylation', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'endoplasmic reticulum calcium ion homeostasis', 'entrainment of circadian clock by photoperiod', 'extrinsic apoptotic signaling pathway', 'fibroblast migration', 'innate immune response', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'intrinsic apoptotic signaling pathway in response to oxidative stress', 'maintenance of protein location in nucleus', 'myeloid cell differentiation', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of interleukin-1 beta production', 'negative regulation of mitotic cell cycle', 'negative regulation of telomerase activity', 'negative regulation of telomere maintenance via telomerase', 'negative regulation of transcription, DNA-templated', 'negative regulation of translation in response to oxidative stress', 'negative regulation of ubiquitin-dependent protein catabolic process', 'oncogene-induced cell senescence', 'PML body organization', 'positive regulation of apoptotic process involved in mammary gland involution', 'positive regulation of defense response to virus by host', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of fibroblast proliferation', 'positive regulation of histone deacetylation', 'positive regulation of peptidyl-lysine acetylation', 'positive regulation of protein localization to chromosome, telomeric region', 'positive regulation of signal transduction by p53 class mediator', 'positive regulation of telomere maintenance', 'positive regulation of transcription, DNA-templated', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein import into nucleus', 'protein stabilization', 'protein targeting', 'protein-containing complex assembly', 'protein-containing complex localization', 'regulation of calcium ion transport into cytosol', 'regulation of cell adhesion', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of double-strand break repair', 'regulation of transcription, DNA-templated', 'response to cytokine', 'response to gamma radiation', 'response to hypoxia', 'response to UV', 'retinoic acid receptor signaling pathway', 'suppression of viral release by host', 'transforming growth factor beta receptor signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'apoptotic process', 'branching involved in mammary gland duct morphogenesis', 'cell fate commitment', 'cellular response to interleukin-4', 'cellular response to leukemia inhibitory factor', 'cellular senescence', 'circadian regulation of gene expression', 'common-partner SMAD protein phosphorylation', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'endoplasmic reticulum calcium ion homeostasis', 'entrainment of circadian clock by photoperiod', 'extrinsic apoptotic signaling pathway', 'fibroblast migration', 'innate immune response', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'intrinsic apoptotic signaling pathway in response to oxidative stress', 'maintenance of protein location in nucleus', 'myeloid cell differentiation', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of interleukin-1 beta production', 'negative regulation of mitotic cell cycle', 'negative regulation of telomerase activity', 'negative regulation of telomere maintenance via telomerase', 'negative regulation of transcription, DNA-templated', 'negative regulation of translation in response to oxidative stress', 'negative regulation of ubiquitin-dependent protein catabolic process', 'oncogene-induced cell senescence', 'PML body organization', 'positive regulation of apoptotic process involved in mammary gland involution', 'positive regulation of defense response to virus by host', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of fibroblast proliferation', 'positive regulation of histone deacetylation', 'positive regulation of peptidyl-lysine acetylation', 'positive regulation of protein localization to chromosome, telomeric region', 'positive regulation of signal transduction by p53 class mediator', 'positive regulation of telomere maintenance', 'positive regulation of transcription, DNA-templated', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein import into nucleus', 'protein stabilization', 'protein targeting', 'protein-containing complex assembly', 'protein-containing complex localization', 'regulation of calcium ion transport into cytosol', 'regulation of cell adhesion', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of double-strand break repair', 'regulation of transcription, DNA-templated', 'response to cytokine', 'response to gamma radiation', 'response to hypoxia', 'response to UV', 'retinoic acid receptor signaling pathway', 'suppression of viral release by host', 'transforming growth factor beta receptor signaling pathway']
Nuclear RNA export factor 1
492
NTF2-related export protein 1
132
7.0
89
0.16
Q9UBU9Q9UKK6['mRNA export from nucleus', 'poly(A)+ mRNA export from nucleus', 'protein transport']['mRNA export from nucleus', 'nucleocytoplasmic transport', 'protein export from nucleus', 'protein import into nucleus']
Integrin beta-2
36
Integrin beta-2
447
7.1
68
0.21
P05107P05107['amyloid-beta clearance', 'apoptotic process', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-cell adhesion', 'cell-cell adhesion via plasma-membrane adhesion molecules', 'cell-cell signaling', 'cell-matrix adhesion', 'cellular response to low-density lipoprotein particle stimulus', 'endodermal cell differentiation', 'heterotypic cell-cell adhesion', 'inflammatory response', 'integrin-mediated signaling pathway', 'leukocyte cell-cell adhesion', 'microglial cell activation', 'negative regulation of dopamine metabolic process', 'neutrophil chemotaxis', 'neutrophil migration', 'phagocytosis, engulfment', 'positive regulation of leukocyte adhesion to vascular endothelial cell', 'positive regulation of neuron death', 'positive regulation of neutrophil degranulation', 'positive regulation of prostaglandin-E synthase activity', 'positive regulation of protein targeting to membrane', 'positive regulation of superoxide anion generation', 'receptor clustering', 'receptor internalization', 'receptor-mediated endocytosis', 'regulation of cell shape', 'regulation of peptidyl-tyrosine phosphorylation']['amyloid-beta clearance', 'apoptotic process', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-cell adhesion', 'cell-cell adhesion via plasma-membrane adhesion molecules', 'cell-cell signaling', 'cell-matrix adhesion', 'cellular response to low-density lipoprotein particle stimulus', 'endodermal cell differentiation', 'heterotypic cell-cell adhesion', 'inflammatory response', 'integrin-mediated signaling pathway', 'leukocyte cell-cell adhesion', 'microglial cell activation', 'negative regulation of dopamine metabolic process', 'neutrophil chemotaxis', 'neutrophil migration', 'phagocytosis, engulfment', 'positive regulation of leukocyte adhesion to vascular endothelial cell', 'positive regulation of neuron death', 'positive regulation of neutrophil degranulation', 'positive regulation of prostaglandin-E synthase activity', 'positive regulation of protein targeting to membrane', 'positive regulation of superoxide anion generation', 'receptor clustering', 'receptor internalization', 'receptor-mediated endocytosis', 'regulation of cell shape', 'regulation of peptidyl-tyrosine phosphorylation']
Serine/threonine-protein kinase receptor R3
443
Serine/threonine-protein kinase receptor R3
389
7.1
63
0.22
P37023P37023['angiogenesis', 'artery development', 'blood circulation', 'blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'blood vessel maturation', 'blood vessel remodeling', 'BMP signaling pathway', 'cellular response to BMP stimulus', 'cellular response to growth factor stimulus', 'cellular response to transforming growth factor beta stimulus', 'dorsal aorta morphogenesis', 'dorsal/ventral pattern formation', 'endocardial cushion morphogenesis', 'endothelial tube morphogenesis', 'heart development', 'in utero embryonic development', 'lymphangiogenesis', 'lymphatic endothelial cell differentiation', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell adhesion', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of cell population proliferation', 'negative regulation of DNA biosynthetic process', 'negative regulation of endothelial cell differentiation', 'negative regulation of endothelial cell migration', 'negative regulation of endothelial cell proliferation', 'negative regulation of focal adhesion assembly', 'negative regulation of gene expression', 'positive regulation of angiogenesis', 'positive regulation of BMP signaling pathway', 'positive regulation of chondrocyte differentiation', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein phosphorylation', 'regulation of blood pressure', 'regulation of blood vessel endothelial cell migration', 'regulation of DNA replication', 'regulation of endothelial cell proliferation', 'regulation of transcription, DNA-templated', 'response to hypoxia', 'retina vasculature development in camera-type eye', 'signal transduction', 'transforming growth factor beta receptor signaling pathway', 'venous blood vessel development', 'wound healing, spreading of epidermal cells']['angiogenesis', 'artery development', 'blood circulation', 'blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'blood vessel maturation', 'blood vessel remodeling', 'BMP signaling pathway', 'cellular response to BMP stimulus', 'cellular response to growth factor stimulus', 'cellular response to transforming growth factor beta stimulus', 'dorsal aorta morphogenesis', 'dorsal/ventral pattern formation', 'endocardial cushion morphogenesis', 'endothelial tube morphogenesis', 'heart development', 'in utero embryonic development', 'lymphangiogenesis', 'lymphatic endothelial cell differentiation', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell adhesion', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of cell population proliferation', 'negative regulation of DNA biosynthetic process', 'negative regulation of endothelial cell differentiation', 'negative regulation of endothelial cell migration', 'negative regulation of endothelial cell proliferation', 'negative regulation of focal adhesion assembly', 'negative regulation of gene expression', 'positive regulation of angiogenesis', 'positive regulation of BMP signaling pathway', 'positive regulation of chondrocyte differentiation', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein phosphorylation', 'regulation of blood pressure', 'regulation of blood vessel endothelial cell migration', 'regulation of DNA replication', 'regulation of endothelial cell proliferation', 'regulation of transcription, DNA-templated', 'response to hypoxia', 'retina vasculature development in camera-type eye', 'signal transduction', 'transforming growth factor beta receptor signaling pathway', 'venous blood vessel development', 'wound healing, spreading of epidermal cells']
Glucocorticoid receptor
463
Glucocorticoid receptor
457
7.1
66
0.21
P79269P79269['cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'chromatin organization', 'positive regulation of transcription by RNA polymerase II']['cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'chromatin organization', 'positive regulation of transcription by RNA polymerase II']
DNA (cytosine-5)-methyltransferase 3A
540
DNA (cytosine-5)-methyltransferase 3A
497
7.1
93
0.15
Q9Y6K1Q9Y6K1['aging', 'C-5 methylation of cytosine', 'cellular response to amino acid stimulus', 'cellular response to bisphenol A', 'cellular response to ethanol', 'cellular response to hypoxia', 'DNA methylation', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'DNA methylation on cytosine', 'DNA methylation-dependent heterochromatin assembly', 'hepatocyte apoptotic process', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron differentiation', 'positive regulation of cell death', 'regulation of gene expression by genomic imprinting', 'response to cocaine', 'response to estradiol', 'response to ionizing radiation', 'response to lead ion', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'spermatogenesis']['aging', 'C-5 methylation of cytosine', 'cellular response to amino acid stimulus', 'cellular response to bisphenol A', 'cellular response to ethanol', 'cellular response to hypoxia', 'DNA methylation', 'DNA methylation involved in embryo development', 'DNA methylation involved in gamete generation', 'DNA methylation on cytosine', 'DNA methylation-dependent heterochromatin assembly', 'hepatocyte apoptotic process', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neuron differentiation', 'positive regulation of cell death', 'regulation of gene expression by genomic imprinting', 'response to cocaine', 'response to estradiol', 'response to ionizing radiation', 'response to lead ion', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'spermatogenesis']
BTB/POZ domain-containing protein KCTD12
294
BTB/POZ domain-containing protein KCTD12
294
7.1
85
0.17
Q96CX2Q96CX2['protein homooligomerization']['protein homooligomerization']
Dopamine beta-hydroxylase
154
Dopamine beta-hydroxylase
154
7.1
47
0.3
P09172P09172['behavioral response to ethanol', 'blood vessel remodeling', 'chemical synaptic transmission', 'dopamine catabolic process', 'fear response', 'glucose homeostasis', 'homoiothermy', 'leukocyte mediated immunity', 'leukocyte migration', 'locomotory behavior', 'maternal behavior', 'memory', 'norepinephrine biosynthetic process', 'octopamine biosynthetic process', 'positive regulation of cold-induced thermogenesis', 'positive regulation of vasoconstriction', 'regulation of extrinsic apoptotic signaling pathway', 'regulation of vascular associated smooth muscle cell proliferation', 'regulation of vascular endothelial cell proliferation', 'response to amphetamine', 'response to pain', 'vasoconstriction', 'visual learning']['behavioral response to ethanol', 'blood vessel remodeling', 'chemical synaptic transmission', 'dopamine catabolic process', 'fear response', 'glucose homeostasis', 'homoiothermy', 'leukocyte mediated immunity', 'leukocyte migration', 'locomotory behavior', 'maternal behavior', 'memory', 'norepinephrine biosynthetic process', 'octopamine biosynthetic process', 'positive regulation of cold-induced thermogenesis', 'positive regulation of vasoconstriction', 'regulation of extrinsic apoptotic signaling pathway', 'regulation of vascular associated smooth muscle cell proliferation', 'regulation of vascular endothelial cell proliferation', 'response to amphetamine', 'response to pain', 'vasoconstriction', 'visual learning']
Mineralocorticoid receptor
645
Mineralocorticoid receptor
639
7.1
65
0.22
P08235P08235['intracellular steroid hormone receptor signaling pathway', 'positive regulation of NIK/NF-kappaB signaling', 'regulation of transcription by RNA polymerase II', 'signal transduction']['intracellular steroid hormone receptor signaling pathway', 'positive regulation of NIK/NF-kappaB signaling', 'regulation of transcription by RNA polymerase II', 'signal transduction']
Group 10 secretory phospholipase A2
125
Group 10 secretory phospholipase A2
125
7.1
79
0.18
O15496O15496['arachidonic acid metabolic process', 'arachidonic acid secretion', 'axon guidance', 'cellular response to leukemia inhibitory factor', 'cholesterol homeostasis', 'defense response to virus', 'erythrocyte maturation', 'fertilization', 'hair follicle morphogenesis', 'intestinal stem cell homeostasis', 'low-density lipoprotein particle remodeling', 'lysophospholipid transport', 'macrophage activation', 'negative regulation of cholesterol efflux', 'negative regulation of cytokine production involved in inflammatory response', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of inflammatory response', 'phosphatidic acid metabolic process', 'phosphatidylcholine catabolic process', 'phosphatidylcholine metabolic process', 'phosphatidylethanolamine metabolic process', 'phosphatidylglycerol metabolic process', 'phosphatidylserine metabolic process', 'phospholipid metabolic process', 'platelet activating factor catabolic process', 'positive regulation of acrosome reaction', 'positive regulation of arachidonic acid secretion', 'positive regulation of lipid storage', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of prostaglandin secretion', 'positive regulation of protein metabolic process', 'production of molecular mediator involved in inflammatory response', 'prostaglandin biosynthetic process', 'regulation of macrophage activation']['arachidonic acid metabolic process', 'arachidonic acid secretion', 'axon guidance', 'cellular response to leukemia inhibitory factor', 'cholesterol homeostasis', 'defense response to virus', 'erythrocyte maturation', 'fertilization', 'hair follicle morphogenesis', 'intestinal stem cell homeostasis', 'low-density lipoprotein particle remodeling', 'lysophospholipid transport', 'macrophage activation', 'negative regulation of cholesterol efflux', 'negative regulation of cytokine production involved in inflammatory response', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of inflammatory response', 'phosphatidic acid metabolic process', 'phosphatidylcholine catabolic process', 'phosphatidylcholine metabolic process', 'phosphatidylethanolamine metabolic process', 'phosphatidylglycerol metabolic process', 'phosphatidylserine metabolic process', 'phospholipid metabolic process', 'platelet activating factor catabolic process', 'positive regulation of acrosome reaction', 'positive regulation of arachidonic acid secretion', 'positive regulation of lipid storage', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of prostaglandin secretion', 'positive regulation of protein metabolic process', 'production of molecular mediator involved in inflammatory response', 'prostaglandin biosynthetic process', 'regulation of macrophage activation']
Histone-lysine N-methyltransferase 2C
1078
Histone-lysine N-methyltransferase 2C
1081
7.3
73
0.19
Q8NEZ4Q8NEZ4['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']
Calcium/calmodulin-dependent protein kinase type II subunit alpha
428
Calcium/calmodulin-dependent protein kinase type II subunit alpha
428
7.3
104
0.13
P11798P11798['angiotensin-activated signaling pathway', 'calcium ion transport', 'calmodulin dependent kinase signaling pathway', 'dendrite morphogenesis', 'dendritic spine development', 'G1/S transition of mitotic cell cycle', 'ionotropic glutamate receptor signaling pathway', 'negative regulation of hydrolase activity', 'NMDA selective glutamate receptor signaling pathway', 'peptidyl-serine phosphorylation', 'peptidyl-threonine autophosphorylation', 'positive regulation of calcium ion transport', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of NF-kappaB transcription factor activity', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of endocannabinoid signaling pathway', 'regulation of mitochondrial membrane permeability involved in apoptotic process', 'regulation of neuron migration', 'regulation of neuronal synaptic plasticity', 'regulation of neurotransmitter receptor localization to postsynaptic specialization membrane', 'regulation of neurotransmitter secretion', 'regulation of protein localization to plasma membrane', 'regulation of synaptic vesicle docking', 'response to ischemia']['angiotensin-activated signaling pathway', 'calcium ion transport', 'calmodulin dependent kinase signaling pathway', 'dendrite morphogenesis', 'dendritic spine development', 'G1/S transition of mitotic cell cycle', 'ionotropic glutamate receptor signaling pathway', 'negative regulation of hydrolase activity', 'NMDA selective glutamate receptor signaling pathway', 'peptidyl-serine phosphorylation', 'peptidyl-threonine autophosphorylation', 'positive regulation of calcium ion transport', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of NF-kappaB transcription factor activity', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of endocannabinoid signaling pathway', 'regulation of mitochondrial membrane permeability involved in apoptotic process', 'regulation of neuron migration', 'regulation of neuronal synaptic plasticity', 'regulation of neurotransmitter receptor localization to postsynaptic specialization membrane', 'regulation of neurotransmitter secretion', 'regulation of protein localization to plasma membrane', 'regulation of synaptic vesicle docking', 'response to ischemia']
Thioredoxin
32
Thioredoxin
62
7.2
73
0.19
P10599P10599['activation of protein kinase B activity', 'cell redox homeostasis', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of protein export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA binding', 'positive regulation of peptidyl-cysteine S-nitrosylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'response to nitric oxide', 'response to radiation']['activation of protein kinase B activity', 'cell redox homeostasis', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of protein export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA binding', 'positive regulation of peptidyl-cysteine S-nitrosylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'response to nitric oxide', 'response to radiation']
Lectin-related NK cell receptor LY49L4
148
Lectin-related NK cell receptor LY49L4
153
7.3
61
0.23
Q9JIP9Q9JIP9[][]
Putative methyltransferase C9orf114
343
Putative methyltransferase C9orf114
108
7.3
87
0.16
Q5T280Q5T280['cell cycle', 'cell division', 'maintenance of centrosome location', 'methylation', 'miRNA processing', 'post-transcriptional regulation of gene expression']['cell cycle', 'cell division', 'maintenance of centrosome location', 'methylation', 'miRNA processing', 'post-transcriptional regulation of gene expression']
Amyloid-beta precursor protein
105
Amyloid-beta precursor protein
105
7.1
60
0.24
P05067P05067['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adult locomotory behavior', 'amyloid fibril formation', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'associative learning', 'astrocyte activation', 'astrocyte activation involved in immune response', 'axo-dendritic transport', 'axon midline choice point recognition', 'axonogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to cAMP', 'cellular response to copper ion', 'cellular response to manganese ion', 'cellular response to nerve growth factor stimulus', 'cellular response to norepinephrine stimulus', 'central nervous system development', 'cholesterol metabolic process', 'cognition', 'collateral sprouting in absence of injury', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'dendrite development', 'endocytosis', 'extracellular matrix organization', 'forebrain development', 'G protein-coupled receptor signaling pathway', 'G2/M transition of mitotic cell cycle', 'innate immune response', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'lipoprotein metabolic process', 'locomotory behavior', 'mating behavior', 'memory', 'microglia development', 'microglial cell activation', 'modulation of excitatory postsynaptic potential', 'mRNA polyadenylation', 'negative regulation of blood circulation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of dendritic spine maintenance', 'negative regulation of gene expression', 'negative regulation of long-term synaptic potentiation', 'negative regulation of miRNA transcription', 'negative regulation of mitochondrion organization', 'negative regulation of neuron death', 'negative regulation of neuron differentiation', 'negative regulation of protein localization to nucleus', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of Wnt signaling pathway', 'neuromuscular process controlling balance', 'neuron apoptotic process', 'neuron cellular homeostasis', 'neuron projection development', 'neuron projection maintenance', 'neuron remodeling', 'Notch signaling pathway', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of amyloid fibril formation', 'positive regulation of apoptotic process', 'positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process', 'positive regulation of cell activation', 'positive regulation of cellular response to thapsigargin', 'positive regulation of cellular response to tunicamycin', 'positive regulation of chemokine production', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelin production', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of G protein-coupled receptor internalization', 'positive regulation of G protein-coupled receptor signaling pathway', 'positive regulation of G2/M transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of histone acetylation', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of JNK cascade', 'positive regulation of long-term synaptic depression', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of membrane protein ectodomain proteolysis', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of oxidative stress-induced neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein import', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein tyrosine kinase activity', 'positive regulation of receptor binding', 'positive regulation of response to endoplasmic reticulum stress', 'positive regulation of superoxide anion generation', 'positive regulation of T cell migration', 'positive regulation of tau-protein kinase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'protein homooligomerization', 'protein phosphorylation', 'protein tetramerization', 'protein trimerization', 'regulation of acetylcholine-gated cation channel activity', 'regulation of amyloid fibril formation', 'regulation of amyloid-beta clearance', 'regulation of cellular protein metabolic process', 'regulation of dendritic spine maintenance', 'regulation of epidermal growth factor-activated receptor activity', 'regulation of gene expression', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of multicellular organism growth', 'regulation of NMDA receptor activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of presynapse assembly', 'regulation of protein tyrosine kinase activity', 'regulation of response to calcium ion', 'regulation of signaling receptor activity', 'regulation of spontaneous synaptic transmission', 'regulation of synapse structure or activity', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of translation', 'regulation of Wnt signaling pathway', 'response to interleukin-1', 'response to lead ion', 'response to oxidative stress', 'response to yeast', 'smooth endoplasmic reticulum calcium ion homeostasis', 'suckling behavior', 'synapse organization', 'synaptic assembly at neuromuscular junction', 'visual learning']
Interferon alpha/beta receptor 2
227
Interferon alpha/beta receptor 2
227
7.0
81
0.18
P48551P48551['cell surface receptor signaling pathway', 'cellular response to virus', 'cytokine-mediated signaling pathway', 'defense response to virus', 'receptor signaling pathway via JAK-STAT', 'response to interferon-alpha', 'response to interferon-beta', 'response to virus', 'type I interferon signaling pathway']['cell surface receptor signaling pathway', 'cellular response to virus', 'cytokine-mediated signaling pathway', 'defense response to virus', 'receptor signaling pathway via JAK-STAT', 'response to interferon-alpha', 'response to interferon-beta', 'response to virus', 'type I interferon signaling pathway']
F-box only protein 11
872
F-box only protein 11
888
7.2
60
0.23
Q86XK2Q86XK2['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']
RNA demethylase ALKBH5
200
RNA demethylase ALKBH5
200
7.2
73
0.19
Q6P6C2Q6P6C2['cell differentiation', 'mRNA export from nucleus', 'mRNA processing', 'oxidative single-stranded RNA demethylation', 'regulation of mRNA stability', 'response to hypoxia', 'spermatogenesis']['cell differentiation', 'mRNA export from nucleus', 'mRNA processing', 'oxidative single-stranded RNA demethylation', 'regulation of mRNA stability', 'response to hypoxia', 'spermatogenesis']
Transforming growth factor beta-3 proprotein
377
Transforming growth factor beta-3 proprotein
348
7.2
81
0.17
P10600P10600['aging', 'BMP signaling pathway', 'cell-cell junction organization', 'detection of hypoxia', 'digestive tract development', 'embryonic neurocranium morphogenesis', 'face morphogenesis', 'female pregnancy', 'frontal suture morphogenesis', 'in utero embryonic development', 'inner ear development', 'lung alveolus development', 'mammary gland development', 'negative regulation of cell population proliferation', 'negative regulation of macrophage cytokine production', 'negative regulation of neuron apoptotic process', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of vascular associated smooth muscle cell proliferation', 'odontogenesis', 'ossification involved in bone remodeling', 'positive regulation of apoptotic process', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of filopodium assembly', 'positive regulation of MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stress fiber assembly', 'positive regulation of tight junction disassembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of cell population proliferation', 'response to estrogen', 'response to hypoxia', 'response to laminar fluid shear stress', 'response to progesterone', 'salivary gland morphogenesis', 'secondary palate development', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'wound healing']['aging', 'BMP signaling pathway', 'cell-cell junction organization', 'detection of hypoxia', 'digestive tract development', 'embryonic neurocranium morphogenesis', 'face morphogenesis', 'female pregnancy', 'frontal suture morphogenesis', 'in utero embryonic development', 'inner ear development', 'lung alveolus development', 'mammary gland development', 'negative regulation of cell population proliferation', 'negative regulation of macrophage cytokine production', 'negative regulation of neuron apoptotic process', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of vascular associated smooth muscle cell proliferation', 'odontogenesis', 'ossification involved in bone remodeling', 'positive regulation of apoptotic process', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of filopodium assembly', 'positive regulation of MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stress fiber assembly', 'positive regulation of tight junction disassembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of cell population proliferation', 'response to estrogen', 'response to hypoxia', 'response to laminar fluid shear stress', 'response to progesterone', 'salivary gland morphogenesis', 'secondary palate development', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'wound healing']
Transforming growth factor beta-3 proprotein
377
Transforming growth factor beta-3 proprotein
378
7.1
85
0.17
P10600P10600['aging', 'BMP signaling pathway', 'cell-cell junction organization', 'detection of hypoxia', 'digestive tract development', 'embryonic neurocranium morphogenesis', 'face morphogenesis', 'female pregnancy', 'frontal suture morphogenesis', 'in utero embryonic development', 'inner ear development', 'lung alveolus development', 'mammary gland development', 'negative regulation of cell population proliferation', 'negative regulation of macrophage cytokine production', 'negative regulation of neuron apoptotic process', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of vascular associated smooth muscle cell proliferation', 'odontogenesis', 'ossification involved in bone remodeling', 'positive regulation of apoptotic process', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of filopodium assembly', 'positive regulation of MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stress fiber assembly', 'positive regulation of tight junction disassembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of cell population proliferation', 'response to estrogen', 'response to hypoxia', 'response to laminar fluid shear stress', 'response to progesterone', 'salivary gland morphogenesis', 'secondary palate development', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'wound healing']['aging', 'BMP signaling pathway', 'cell-cell junction organization', 'detection of hypoxia', 'digestive tract development', 'embryonic neurocranium morphogenesis', 'face morphogenesis', 'female pregnancy', 'frontal suture morphogenesis', 'in utero embryonic development', 'inner ear development', 'lung alveolus development', 'mammary gland development', 'negative regulation of cell population proliferation', 'negative regulation of macrophage cytokine production', 'negative regulation of neuron apoptotic process', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of vascular associated smooth muscle cell proliferation', 'odontogenesis', 'ossification involved in bone remodeling', 'positive regulation of apoptotic process', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of filopodium assembly', 'positive regulation of MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stress fiber assembly', 'positive regulation of tight junction disassembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of cell population proliferation', 'response to estrogen', 'response to hypoxia', 'response to laminar fluid shear stress', 'response to progesterone', 'salivary gland morphogenesis', 'secondary palate development', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'wound healing']
MHC class II HLA-DQ-alpha chain
11
HLA class II histocompatibility antigen, DQ beta 1 chain
111
6.3
91
0.17
Q30066Q5SU54['adaptive immune response', 'antigen processing and presentation of peptide or polysaccharide antigen via MHC class II']['adaptive immune response', 'antigen processing and presentation of peptide or polysaccharide antigen via MHC class II']
Cytidine deaminase
102
Cytidine deaminase
59
6.3
62
0.25
P32320P32320['cell surface receptor signaling pathway', 'cellular response to external biotic stimulus', 'cytidine deamination', 'cytosine metabolic process', 'negative regulation of cell growth', 'negative regulation of nucleotide metabolic process', 'pyrimidine-containing compound salvage', 'response to cycloheximide', 'UMP salvage']['cell surface receptor signaling pathway', 'cellular response to external biotic stimulus', 'cytidine deamination', 'cytosine metabolic process', 'negative regulation of cell growth', 'negative regulation of nucleotide metabolic process', 'pyrimidine-containing compound salvage', 'response to cycloheximide', 'UMP salvage']
Immunoglobulin heavy constant alpha 1
180
Immunoglobulin heavy constant alpha 1
182
6.3
52
0.3
P01876P01876['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']
Crk-like protein
249
Crk-like protein
249
6.3
37
0.43
P46109P46109['acetylcholine receptor signaling pathway', 'activation of GTPase activity', 'anterior/posterior pattern specification', 'B cell apoptotic process', 'blood vessel development', 'cell chemotaxis', 'cell migration', 'cellular response to interleukin-7', 'cellular response to transforming growth factor beta stimulus', 'cellular response to xenobiotic stimulus', 'cerebellar neuron development', 'cerebral cortex development', 'cranial skeletal system development', 'dendrite development', 'endothelin receptor signaling pathway', 'establishment of cell polarity', 'fibroblast growth factor receptor signaling pathway', 'helper T cell diapedesis', 'hippocampus development', 'intracellular signal transduction', 'JNK cascade', 'lipid metabolic process', 'male gonad development', 'negative regulation of gene expression', 'negative regulation of protein phosphorylation', 'neuron migration', 'outflow tract morphogenesis', 'parathyroid gland development', 'pharynx development', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of glial cell migration', 'positive regulation of protein phosphorylation', 'positive regulation of substrate adhesion-dependent cell spreading', 'Ras protein signal transduction', 'reelin-mediated signaling pathway', 'regulation of cell adhesion mediated by integrin', 'regulation of cell growth', 'regulation of dendrite development', 'regulation of skeletal muscle acetylcholine-gated channel clustering', 'regulation of T cell migration', 'retinoic acid receptor signaling pathway', 'signal transduction', 'single fertilization', 'spermatogenesis', 'synapse assembly', 'T cell receptor signaling pathway', 'thymus development', 'urogenital system development']['acetylcholine receptor signaling pathway', 'activation of GTPase activity', 'anterior/posterior pattern specification', 'B cell apoptotic process', 'blood vessel development', 'cell chemotaxis', 'cell migration', 'cellular response to interleukin-7', 'cellular response to transforming growth factor beta stimulus', 'cellular response to xenobiotic stimulus', 'cerebellar neuron development', 'cerebral cortex development', 'cranial skeletal system development', 'dendrite development', 'endothelin receptor signaling pathway', 'establishment of cell polarity', 'fibroblast growth factor receptor signaling pathway', 'helper T cell diapedesis', 'hippocampus development', 'intracellular signal transduction', 'JNK cascade', 'lipid metabolic process', 'male gonad development', 'negative regulation of gene expression', 'negative regulation of protein phosphorylation', 'neuron migration', 'outflow tract morphogenesis', 'parathyroid gland development', 'pharynx development', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of glial cell migration', 'positive regulation of protein phosphorylation', 'positive regulation of substrate adhesion-dependent cell spreading', 'Ras protein signal transduction', 'reelin-mediated signaling pathway', 'regulation of cell adhesion mediated by integrin', 'regulation of cell growth', 'regulation of dendrite development', 'regulation of skeletal muscle acetylcholine-gated channel clustering', 'regulation of T cell migration', 'retinoic acid receptor signaling pathway', 'signal transduction', 'single fertilization', 'spermatogenesis', 'synapse assembly', 'T cell receptor signaling pathway', 'thymus development', 'urogenital system development']
E3 ubiquitin/ISG15 ligase TRIM25
351
E3 ubiquitin/ISG15 ligase TRIM25
351
6.3
58
0.27
Q14258Q14258['cellular response to leukemia inhibitory factor', 'innate immune response', 'negative regulation of viral entry into host cell', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'protein monoubiquitination', 'regulation of protein localization', 'regulation of viral entry into host cell', 'response to estrogen', 'response to vitamin D', 'suppression of viral release by host', 'ubiquitin-dependent ERAD pathway', 'ubiquitin-dependent protein catabolic process', 'viral release from host cell']['cellular response to leukemia inhibitory factor', 'innate immune response', 'negative regulation of viral entry into host cell', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'protein monoubiquitination', 'regulation of protein localization', 'regulation of viral entry into host cell', 'response to estrogen', 'response to vitamin D', 'suppression of viral release by host', 'ubiquitin-dependent ERAD pathway', 'ubiquitin-dependent protein catabolic process', 'viral release from host cell']
cGMP-dependent protein kinase 2
183
cGMP-dependent protein kinase 2
183
6.2
76
0.21
Q13237Q13237['negative regulation of chloride transport', 'negative regulation of chondrocyte proliferation', 'peptidyl-serine autophosphorylation', 'protein localization to plasma membrane', 'protein phosphorylation', 'regulation of chondrocyte differentiation', 'signal transduction', 'tetrahydrobiopterin metabolic process']['negative regulation of chloride transport', 'negative regulation of chondrocyte proliferation', 'peptidyl-serine autophosphorylation', 'protein localization to plasma membrane', 'protein phosphorylation', 'regulation of chondrocyte differentiation', 'signal transduction', 'tetrahydrobiopterin metabolic process']
Regulator of G-protein signaling 3
314
Regulator of G-protein signaling 3
314
6.2
72
0.22
P49796P49796['G protein-coupled receptor signaling pathway', 'negative regulation of signal transduction', 'regulation of G protein-coupled receptor signaling pathway', 'signal transduction']['G protein-coupled receptor signaling pathway', 'negative regulation of signal transduction', 'regulation of G protein-coupled receptor signaling pathway', 'signal transduction']
Mothers against decapentaplegic homolog 2
374
Zinc finger FYVE domain-containing protein 9
783
6.2
82
0.2
Q15796O95405['activin receptor signaling pathway', 'adrenal gland development', 'anatomical structure morphogenesis', 'anterior/posterior pattern specification', 'BMP signaling pathway', 'cell differentiation', 'cell fate commitment', 'common-partner SMAD protein phosphorylation', 'embryonic cranial skeleton morphogenesis', 'embryonic foregut morphogenesis', 'endoderm formation', 'gastrulation', 'in utero embryonic development', 'insulin secretion', 'intracellular signal transduction', 'lung development', 'mesoderm formation', 'negative regulation of cell population proliferation', 'negative regulation of transcription, DNA-templated', 'nodal signaling pathway', 'organ growth', 'pancreas development', 'paraxial mesoderm morphogenesis', 'pericardium development', 'positive regulation of BMP signaling pathway', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of gene expression', 'positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'post-embryonic development', 'primary miRNA processing', 'regulation of binding', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to glucose', 'secondary palate development', 'signal transduction involved in regulation of gene expression', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transcription, DNA-templated', 'transforming growth factor beta receptor signaling pathway', 'ureteric bud development', 'wound healing', 'zygotic specification of dorsal/ventral axis']['endocytosis', 'endosomal transport', 'transforming growth factor beta receptor signaling pathway']
Tumor necrosis factor receptor superfamily member 9
64
Tumor necrosis factor receptor superfamily member 9
44
7.1
75
0.19
P20334P20334['apoptotic process', 'negative regulation of cell population proliferation', 'regulation of cell population proliferation', 'regulation of immature T cell proliferation in thymus']['apoptotic process', 'negative regulation of cell population proliferation', 'regulation of cell population proliferation', 'regulation of immature T cell proliferation in thymus']
Periaxin
86
Periaxin
86
7.1
68
0.21
Q9BXM0Q9BXM0['axon ensheathment', 'peripheral nervous system myelin maintenance', 'regulation of RNA splicing']['axon ensheathment', 'peripheral nervous system myelin maintenance', 'regulation of RNA splicing']
Phospholipase A2, membrane associated
103
Phospholipase A2, membrane associated
103
6.3
76
0.21
P14555P14555['arachidonic acid secretion', 'cytolysis', 'defense response to Gram-positive bacterium', 'inflammatory response', 'intestinal stem cell homeostasis', 'lipid catabolic process', 'low-density lipoprotein particle remodeling', 'phosphatidic acid metabolic process', 'phosphatidylcholine metabolic process', 'phosphatidylethanolamine metabolic process', 'phospholipid metabolic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of inflammatory response', 'positive regulation of macrophage derived foam cell differentiation', 'regulation of neutrophil activation']['arachidonic acid secretion', 'cytolysis', 'defense response to Gram-positive bacterium', 'inflammatory response', 'intestinal stem cell homeostasis', 'lipid catabolic process', 'low-density lipoprotein particle remodeling', 'phosphatidic acid metabolic process', 'phosphatidylcholine metabolic process', 'phosphatidylethanolamine metabolic process', 'phospholipid metabolic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of inflammatory response', 'positive regulation of macrophage derived foam cell differentiation', 'regulation of neutrophil activation']
Glutamate receptor 2
78
Glutamate receptor 3
334
7.9
75
0.17
P19491P19492['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']['regulation of receptor recycling', 'response to fungicide', 'response to lithium ion']
Protein ENL
99
Protein ENL
99
7.9
67
0.19
Q03111Q03111['chromatin remodeling', 'histone acetylation', 'negative regulation of protein kinase activity', 'regulation of transcription by RNA polymerase II']['chromatin remodeling', 'histone acetylation', 'negative regulation of protein kinase activity', 'regulation of transcription by RNA polymerase II']
Histone-lysine N-methyltransferase 2C
1081
Histone-lysine N-methyltransferase 2C
1081
7.9
74
0.17
Q8NEZ4Q8NEZ4['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']
CCR4-NOT transcription complex subunit 7
202
Protein Tob1
57
8.1
82
0.15
Q9UIV1P50616['deadenylation-dependent decapping of nuclear-transcribed mRNA', 'defense response to virus', 'exonucleolytic catabolism of deadenylated mRNA', 'gene silencing by RNA', 'miRNA-mediated gene silencing', 'negative regulation of cell population proliferation', 'negative regulation of gene expression', 'negative regulation of transcription, DNA-templated', 'negative regulation of type I interferon-mediated signaling pathway', 'nuclear-transcribed mRNA poly(A) tail shortening', 'P-body assembly', 'positive regulation of cell population proliferation', 'positive regulation of mRNA catabolic process', 'positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay', 'positive regulation of nuclear-transcribed mRNA poly(A) tail shortening', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of viral genome replication', 'regulation of tyrosine phosphorylation of STAT protein']['negative regulation of BMP signaling pathway', 'negative regulation of cell population proliferation', 'negative regulation of nuclear-transcribed mRNA poly(A) tail shortening', 'negative regulation of osteoblast differentiation', 'negative regulation of translation', 'positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay', 'positive regulation of nuclear-transcribed mRNA poly(A) tail shortening', 'regulation of gene expression', 'regulation of SMAD protein signal transduction']
Complement C5
704
Complement C5
711
7.9
70
0.18
P01031P01031['cell surface receptor signaling pathway', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'G protein-coupled receptor signaling pathway', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']['cell surface receptor signaling pathway', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'G protein-coupled receptor signaling pathway', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']
Glucocorticoid receptor
473
Glucocorticoid receptor
463
7.9
74
0.17
P79269P79269['cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'chromatin organization', 'positive regulation of transcription by RNA polymerase II']['cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'chromatin organization', 'positive regulation of transcription by RNA polymerase II']
Growth factor receptor-bound protein 7
526
Growth factor receptor-bound protein 7
526
7.9
79
0.16
Q14451Q14451['epidermal growth factor receptor signaling pathway', 'negative regulation of translation', 'positive regulation of cell migration', 'stress granule assembly']['epidermal growth factor receptor signaling pathway', 'negative regulation of translation', 'positive regulation of cell migration', 'stress granule assembly']
Fatty acid-binding protein 5
47
Fatty acid-binding protein 5
67
7.9
53
0.24
Q01469Q01469['epidermis development', 'fatty acid transport', 'glucose homeostasis', 'glucose metabolic process', 'lipid metabolic process', 'lipid transport across blood-brain barrier', 'long-chain fatty acid transport', 'negative regulation of glucose transmembrane transport', 'phosphatidylcholine biosynthetic process', 'positive regulation of cold-induced thermogenesis', 'positive regulation of peroxisome proliferator activated receptor signaling pathway', 'regulation of prostaglandin biosynthetic process', 'regulation of retrograde trans-synaptic signaling by endocanabinoid', 'regulation of sensory perception of pain']['epidermis development', 'fatty acid transport', 'glucose homeostasis', 'glucose metabolic process', 'lipid metabolic process', 'lipid transport across blood-brain barrier', 'long-chain fatty acid transport', 'negative regulation of glucose transmembrane transport', 'phosphatidylcholine biosynthetic process', 'positive regulation of cold-induced thermogenesis', 'positive regulation of peroxisome proliferator activated receptor signaling pathway', 'regulation of prostaglandin biosynthetic process', 'regulation of retrograde trans-synaptic signaling by endocanabinoid', 'regulation of sensory perception of pain']
E3 ubiquitin-protein ligase RNF13
278
E3 ubiquitin-protein ligase RNF13
266
7.9
74
0.17
O43567O43567['organelle localization', 'positive regulation of stress-activated protein kinase signaling cascade', 'protein autoubiquitination', 'ubiquitin-dependent protein catabolic process']['organelle localization', 'positive regulation of stress-activated protein kinase signaling cascade', 'protein autoubiquitination', 'ubiquitin-dependent protein catabolic process']
Coagulation factor XIII A chain
424
Coagulation factor XIII A chain
424
8.0
70
0.18
P00488P00488['blood coagulation', 'blood coagulation, fibrin clot formation', 'peptide cross-linking']['blood coagulation', 'blood coagulation, fibrin clot formation', 'peptide cross-linking']
Neutrophil elastase
55
Antileukoproteinase
122
8.0
85
0.15
P08246P03973['acute inflammatory response to antigenic stimulus', 'biosynthetic process of antibacterial peptides active against Gram-negative bacteria', 'cellular calcium ion homeostasis', 'defense response to bacterium', 'extracellular matrix disassembly', 'leukocyte migration involved in inflammatory response', 'negative regulation of chemokine production', 'negative regulation of chemotaxis', 'negative regulation of inflammatory response', 'negative regulation of interleukin-8 production', 'negative regulation of transcription by RNA polymerase II', 'neutrophil-mediated killing of fungus', 'neutrophil-mediated killing of gram-negative bacterium', 'phagocytosis', 'positive regulation of immune response', 'positive regulation of interleukin-8 production', 'positive regulation of leukocyte tethering or rolling', 'positive regulation of MAP kinase activity', 'positive regulation of smooth muscle cell proliferation', 'protein catabolic process', 'proteolysis', 'pyroptosis', 'response to lipopolysaccharide', 'response to UV', 'response to yeast']['antibacterial humoral response', 'immune response', 'innate immune response', 'modulation of process of another organism', 'negative regulation of protein binding', 'negative regulation of viral genome replication', 'response to lipopolysaccharide']
Corticotropin-releasing factor receptor 1
128
Corticotropin-releasing factor receptor 1
128
7.9
66
0.19
P34998P34998['activation of adenylate cyclase activity', 'adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'adrenal gland development', 'behavioral response to ethanol', 'cell surface receptor signaling pathway', 'cellular response to corticotropin-releasing hormone stimulus', 'corticotropin secretion', 'fear response', 'female pregnancy', 'general adaptation syndrome, behavioral process', 'immune response', 'negative regulation of voltage-gated calcium channel activity', 'parturition', 'regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway', 'regulation of corticosterone secretion']['activation of adenylate cyclase activity', 'adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'adrenal gland development', 'behavioral response to ethanol', 'cell surface receptor signaling pathway', 'cellular response to corticotropin-releasing hormone stimulus', 'corticotropin secretion', 'fear response', 'female pregnancy', 'general adaptation syndrome, behavioral process', 'immune response', 'negative regulation of voltage-gated calcium channel activity', 'parturition', 'regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway', 'regulation of corticosterone secretion']
Chymotrypsin-like elastase family member 1
72
Elafin
83
7.9
98
0.13
P00772P19957['proteolysis']['antibacterial humoral response', 'copulation', 'innate immune response', 'peptide cross-linking']
Complement C5
1159
Complement C5
1159
7.9
70
0.18
P01031P01031['cell surface receptor signaling pathway', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'G protein-coupled receptor signaling pathway', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']['cell surface receptor signaling pathway', 'chemotaxis', 'complement activation', 'complement activation, alternative pathway', 'complement activation, classical pathway', 'cytolysis', 'G protein-coupled receptor signaling pathway', 'in utero embryonic development', 'inflammatory response', 'negative regulation of macrophage chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of chemokine production', 'positive regulation of immune response', 'positive regulation of vascular endothelial growth factor production']
Glycoprotein hormones alpha chain
55
Follitropin subunit beta
102
7.9
77
0.16
Q96QJ4P01225[]['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Integrator complex subunit 13
406
Integrator complex subunit 14
310
8.1
78
0.16
Q9NVM9Q96SY0['cell division', 'centrosome localization', 'flagellated sperm motility', 'mitotic spindle organization', 'protein localization to nuclear envelope', 'regulation of fertilization', 'regulation of mitotic cell cycle', 'regulation of transcription elongation from RNA polymerase II promoter', 'snRNA processing']['regulation of transcription elongation from RNA polymerase II promoter', "snRNA 3'-end processing", 'snRNA processing']
Leukocyte immunoglobulin-like receptor subfamily A member 2
195
Leukocyte immunoglobulin-like receptor subfamily A member 2
155
8.0
78
0.16
Q8N149Q8N149['cytokine-mediated signaling pathway', 'defense response', 'innate immune response', 'innate immune response activating cell surface receptor signaling pathway', 'negative regulation of lipopolysaccharide-mediated signaling pathway', 'negative regulation of toll-like receptor 4 signaling pathway', 'neutrophil activation involved in immune response', 'positive regulation of calcium ion transport', 'positive regulation of cell activation', 'positive regulation of granulocyte colony-stimulating factor production', 'positive regulation of granulocyte macrophage colony-stimulating factor production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of tumor necrosis factor production', 'signal transduction']['cytokine-mediated signaling pathway', 'defense response', 'innate immune response', 'innate immune response activating cell surface receptor signaling pathway', 'negative regulation of lipopolysaccharide-mediated signaling pathway', 'negative regulation of toll-like receptor 4 signaling pathway', 'neutrophil activation involved in immune response', 'positive regulation of calcium ion transport', 'positive regulation of cell activation', 'positive regulation of granulocyte colony-stimulating factor production', 'positive regulation of granulocyte macrophage colony-stimulating factor production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of tumor necrosis factor production', 'signal transduction']
APOBEC3H
88
APOBEC3H
85
8.1
74
0.17
B7TQM6B7TQM6[][]
Ubl carboxyl-terminal hydrolase 18
345
Ubl carboxyl-terminal hydrolase 18
345
8.1
55
0.23
Q9WTV6Q9WTV6['negative regulation of type I interferon-mediated signaling pathway', 'protein deubiquitination', 'regulation of inflammatory response', 'response to bacterium', 'response to stilbenoid', 'ubiquitin-dependent protein catabolic process']['negative regulation of type I interferon-mediated signaling pathway', 'protein deubiquitination', 'regulation of inflammatory response', 'response to bacterium', 'response to stilbenoid', 'ubiquitin-dependent protein catabolic process']
Hydroxymethylglutaryl-CoA synthase, mitochondrial
454
Hydroxymethylglutaryl-CoA synthase, mitochondrial
454
8.1
66
0.19
P54868P54868['acetyl-CoA metabolic process', 'adipose tissue development', 'brain development', 'cellular response to amino acid stimulus', 'cellular response to fatty acid', 'cellular response to glucocorticoid stimulus', 'cellular response to insulin stimulus', 'cellular response to lipopolysaccharide', 'cholesterol biosynthetic process', 'farnesyl diphosphate biosynthetic process, mevalonate pathway', 'ketone body biosynthetic process', 'kidney development', 'liver development', 'lung development', 'midgut development', 'multicellular organismal response to stress', 'response to cAMP', 'response to ethanol', 'response to glucagon', 'response to growth hormone', 'response to linoleic acid', 'response to metal ion', 'response to monosaccharide', 'response to nutrient', 'response to prostaglandin F', 'response to starvation', 'response to temperature stimulus', 'response to testosterone', 'response to triglyceride', 'response to xenobiotic stimulus']['acetyl-CoA metabolic process', 'adipose tissue development', 'brain development', 'cellular response to amino acid stimulus', 'cellular response to fatty acid', 'cellular response to glucocorticoid stimulus', 'cellular response to insulin stimulus', 'cellular response to lipopolysaccharide', 'cholesterol biosynthetic process', 'farnesyl diphosphate biosynthetic process, mevalonate pathway', 'ketone body biosynthetic process', 'kidney development', 'liver development', 'lung development', 'midgut development', 'multicellular organismal response to stress', 'response to cAMP', 'response to ethanol', 'response to glucagon', 'response to growth hormone', 'response to linoleic acid', 'response to metal ion', 'response to monosaccharide', 'response to nutrient', 'response to prostaglandin F', 'response to starvation', 'response to temperature stimulus', 'response to testosterone', 'response to triglyceride', 'response to xenobiotic stimulus']
Dual specificity protein phosphatase 16
50
Dual specificity protein phosphatase 16
50
8.1
77
0.16
Q9BY84Q9BY84['dephosphorylation', 'MAPK export from nucleus', 'negative regulation of JUN kinase activity', 'negative regulation of MAPK cascade', 'protein dephosphorylation']['dephosphorylation', 'MAPK export from nucleus', 'negative regulation of JUN kinase activity', 'negative regulation of MAPK cascade', 'protein dephosphorylation']
Intersectin-1
1410
Intersectin-1
1410
7.4
73
0.18
Q9Z0R4Q9Z0R4['clathrin-dependent synaptic vesicle endocytosis', 'endocytosis', 'endosomal transport', 'exocytosis', 'negative regulation of neuron apoptotic process', 'neuron apoptotic process', 'positive regulation of caveolin-mediated endocytosis', 'positive regulation of dendritic spine development', 'positive regulation of growth hormone secretion', 'positive regulation of protein kinase B signaling', 'protein localization', 'protein transport', 'regulation of modification of postsynaptic actin cytoskeleton', 'small GTPase mediated signal transduction', 'synaptic vesicle endocytosis']['clathrin-dependent synaptic vesicle endocytosis', 'endocytosis', 'endosomal transport', 'exocytosis', 'negative regulation of neuron apoptotic process', 'neuron apoptotic process', 'positive regulation of caveolin-mediated endocytosis', 'positive regulation of dendritic spine development', 'positive regulation of growth hormone secretion', 'positive regulation of protein kinase B signaling', 'protein localization', 'protein transport', 'regulation of modification of postsynaptic actin cytoskeleton', 'small GTPase mediated signal transduction', 'synaptic vesicle endocytosis']
Serine/threonine-protein kinase Nek1
175
Serine/threonine-protein kinase Nek1
276
7.4
76
0.18
Q96PY6Q96PY6['cell cycle', 'cell division', 'cilium assembly', 'protein phosphorylation']['cell cycle', 'cell division', 'cilium assembly', 'protein phosphorylation']
ATP-dependent RNA helicase DHX58
559
ATP-dependent RNA helicase DHX58
615
7.4
62
0.22
Q96C10Q96C10['cytoplasmic pattern recognition receptor signaling pathway in response to virus', 'innate immune response', 'negative regulation of innate immune response', 'negative regulation of MDA-5 signaling pathway', 'negative regulation of RIG-I signaling pathway', 'negative regulation of type I interferon production', 'positive regulation of interferon-beta production', 'positive regulation of MDA-5 signaling pathway', 'positive regulation of RIG-I signaling pathway', 'positive regulation of type I interferon production', 'regulation of innate immune response', 'response to bacterium', 'response to virus']['cytoplasmic pattern recognition receptor signaling pathway in response to virus', 'innate immune response', 'negative regulation of innate immune response', 'negative regulation of MDA-5 signaling pathway', 'negative regulation of RIG-I signaling pathway', 'negative regulation of type I interferon production', 'positive regulation of interferon-beta production', 'positive regulation of MDA-5 signaling pathway', 'positive regulation of RIG-I signaling pathway', 'positive regulation of type I interferon production', 'regulation of innate immune response', 'response to bacterium', 'response to virus']
MORC family CW-type zinc finger protein 3
446
MORC family CW-type zinc finger protein 3
435
7.5
79
0.17
Q14149Q14149['innate immune response', 'maintenance of protein location in nucleus', 'negative regulation of fibroblast proliferation', 'peptidyl-serine phosphorylation', 'positive regulation of cellular senescence', 'post-embryonic development', 'protein phosphorylation', 'protein stabilization']['innate immune response', 'maintenance of protein location in nucleus', 'negative regulation of fibroblast proliferation', 'peptidyl-serine phosphorylation', 'positive regulation of cellular senescence', 'post-embryonic development', 'protein phosphorylation', 'protein stabilization']
Thioredoxin
35
Thioredoxin
62
7.5
69
0.19
P10599P10599['activation of protein kinase B activity', 'cell redox homeostasis', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of protein export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA binding', 'positive regulation of peptidyl-cysteine S-nitrosylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'response to nitric oxide', 'response to radiation']['activation of protein kinase B activity', 'cell redox homeostasis', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of protein export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA binding', 'positive regulation of peptidyl-cysteine S-nitrosylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'response to nitric oxide', 'response to radiation']
Phospholipase A2, membrane associated
79
Phospholipase A2, membrane associated
79
7.5
82
0.16
P14555P14555['arachidonic acid secretion', 'cytolysis', 'defense response to Gram-positive bacterium', 'inflammatory response', 'intestinal stem cell homeostasis', 'lipid catabolic process', 'low-density lipoprotein particle remodeling', 'phosphatidic acid metabolic process', 'phosphatidylcholine metabolic process', 'phosphatidylethanolamine metabolic process', 'phospholipid metabolic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of inflammatory response', 'positive regulation of macrophage derived foam cell differentiation', 'regulation of neutrophil activation']['arachidonic acid secretion', 'cytolysis', 'defense response to Gram-positive bacterium', 'inflammatory response', 'intestinal stem cell homeostasis', 'lipid catabolic process', 'low-density lipoprotein particle remodeling', 'phosphatidic acid metabolic process', 'phosphatidylcholine metabolic process', 'phosphatidylethanolamine metabolic process', 'phospholipid metabolic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of inflammatory response', 'positive regulation of macrophage derived foam cell differentiation', 'regulation of neutrophil activation']
Chromodomain-helicase-DNA-binding protein 5
622
Chromodomain-helicase-DNA-binding protein 5
622
7.5
67
0.2
Q8TDI0Q8TDI0['cerebral cortex neuron differentiation', 'chromatin remodeling', 'histone H3-K27 trimethylation', 'histone H4 acetylation', 'negative regulation of cell population proliferation', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of signal transduction by p53 class mediator', 'regulation of transcription by RNA polymerase II', 'spermatogenesis, exchange of chromosomal proteins']['cerebral cortex neuron differentiation', 'chromatin remodeling', 'histone H3-K27 trimethylation', 'histone H4 acetylation', 'negative regulation of cell population proliferation', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of signal transduction by p53 class mediator', 'regulation of transcription by RNA polymerase II', 'spermatogenesis, exchange of chromosomal proteins']
Bone morphogenetic protein 6
445
Bone morphogenetic protein 6
477
7.4
77
0.17
P22004P22004['BMP signaling pathway', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'cellular response to iron ion', 'cellular response to mechanical stimulus', 'endochondral ossification', 'eye development', 'immune response', 'inflammatory response', 'kidney development', 'male genitalia development', 'multicellular organismal iron ion homeostasis', 'negative regulation of adherens junction organization', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of transcription by RNA polymerase II', 'neuron differentiation', 'osteoblast differentiation', 'positive regulation of aldosterone biosynthetic process', 'positive regulation of aldosterone secretion', 'positive regulation of bone mineralization', 'positive regulation of cell population proliferation', 'positive regulation of chondrocyte differentiation', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of gene expression', 'positive regulation of lipopolysaccharide-mediated signaling pathway', 'positive regulation of neuron differentiation', 'positive regulation of osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vascular permeability', 'response to activity', 'response to glucocorticoid', 'response to magnesium ion', 'response to retinoic acid', 'skeletal system development', 'SMAD protein signal transduction', 'type B pancreatic cell development']['BMP signaling pathway', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'cellular response to iron ion', 'cellular response to mechanical stimulus', 'endochondral ossification', 'eye development', 'immune response', 'inflammatory response', 'kidney development', 'male genitalia development', 'multicellular organismal iron ion homeostasis', 'negative regulation of adherens junction organization', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of transcription by RNA polymerase II', 'neuron differentiation', 'osteoblast differentiation', 'positive regulation of aldosterone biosynthetic process', 'positive regulation of aldosterone secretion', 'positive regulation of bone mineralization', 'positive regulation of cell population proliferation', 'positive regulation of chondrocyte differentiation', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of gene expression', 'positive regulation of lipopolysaccharide-mediated signaling pathway', 'positive regulation of neuron differentiation', 'positive regulation of osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vascular permeability', 'response to activity', 'response to glucocorticoid', 'response to magnesium ion', 'response to retinoic acid', 'skeletal system development', 'SMAD protein signal transduction', 'type B pancreatic cell development']
Elafin
109
Elafin
109
7.4
64
0.21
P19957P19957['antibacterial humoral response', 'copulation', 'innate immune response', 'peptide cross-linking']['antibacterial humoral response', 'copulation', 'innate immune response', 'peptide cross-linking']
Thioredoxin
73
Thioredoxin
69
7.5
57
0.24
P10599P10599['activation of protein kinase B activity', 'cell redox homeostasis', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of protein export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA binding', 'positive regulation of peptidyl-cysteine S-nitrosylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'response to nitric oxide', 'response to radiation']['activation of protein kinase B activity', 'cell redox homeostasis', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of protein export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA binding', 'positive regulation of peptidyl-cysteine S-nitrosylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'response to nitric oxide', 'response to radiation']
ATP-dependent RNA helicase DHX8
637
ATP-dependent RNA helicase DHX8
651
7.5
82
0.16
Q14562Q14562['mRNA splicing, via spliceosome', 'RNA processing', 'RNA splicing', 'spliceosomal complex disassembly']['mRNA splicing, via spliceosome', 'RNA processing', 'RNA splicing', 'spliceosomal complex disassembly']
Histone deacetylase 6
1145
Histone deacetylase 6
1120
7.5
87
0.15
Q9UBN7Q9UBN7['aggresome assembly', 'autophagy', 'axonal transport of mitochondrion', 'cellular response to hydrogen peroxide', 'cellular response to misfolded protein', 'cellular response to topologically incorrect protein', 'cilium assembly', 'cilium disassembly', 'collateral sprouting', 'dendritic spine morphogenesis', 'histone deacetylation', 'Hsp90 deacetylation', 'intracellular protein transport', 'lysosome localization', 'negative regulation of hydrogen peroxide metabolic process', 'negative regulation of microtubule depolymerization', 'negative regulation of oxidoreductase activity', 'negative regulation of protein-containing complex assembly', 'negative regulation of protein-containing complex disassembly', 'negative regulation of proteolysis', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization', 'peptidyl-lysine deacetylation', 'polyubiquitinated misfolded protein transport', 'positive regulation of epithelial cell migration', 'positive regulation of hydrogen peroxide-mediated programmed cell death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of signaling receptor activity', 'protein deacetylation', 'protein destabilization', 'protein polyubiquitination', 'protein quality control for misfolded or incompletely synthesized proteins', 'protein-containing complex disassembly', 'regulation of androgen receptor signaling pathway', 'regulation of autophagy', 'regulation of autophagy of mitochondrion', 'regulation of establishment of protein localization', 'regulation of fat cell differentiation', 'regulation of gene expression, epigenetic', 'regulation of macroautophagy', 'regulation of microtubule-based movement', 'regulation of protein stability', 'response to growth factor', 'response to misfolded protein', 'tubulin deacetylation', 'ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway']['aggresome assembly', 'autophagy', 'axonal transport of mitochondrion', 'cellular response to hydrogen peroxide', 'cellular response to misfolded protein', 'cellular response to topologically incorrect protein', 'cilium assembly', 'cilium disassembly', 'collateral sprouting', 'dendritic spine morphogenesis', 'histone deacetylation', 'Hsp90 deacetylation', 'intracellular protein transport', 'lysosome localization', 'negative regulation of hydrogen peroxide metabolic process', 'negative regulation of microtubule depolymerization', 'negative regulation of oxidoreductase activity', 'negative regulation of protein-containing complex assembly', 'negative regulation of protein-containing complex disassembly', 'negative regulation of proteolysis', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization', 'peptidyl-lysine deacetylation', 'polyubiquitinated misfolded protein transport', 'positive regulation of epithelial cell migration', 'positive regulation of hydrogen peroxide-mediated programmed cell death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of signaling receptor activity', 'protein deacetylation', 'protein destabilization', 'protein polyubiquitination', 'protein quality control for misfolded or incompletely synthesized proteins', 'protein-containing complex disassembly', 'regulation of androgen receptor signaling pathway', 'regulation of autophagy', 'regulation of autophagy of mitochondrion', 'regulation of establishment of protein localization', 'regulation of fat cell differentiation', 'regulation of gene expression, epigenetic', 'regulation of macroautophagy', 'regulation of microtubule-based movement', 'regulation of protein stability', 'response to growth factor', 'response to misfolded protein', 'tubulin deacetylation', 'ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway']
Regulator of G-protein signaling 3
354
Regulator of G-protein signaling 3
315
7.5
67
0.2
P49796P49796['G protein-coupled receptor signaling pathway', 'negative regulation of signal transduction', 'regulation of G protein-coupled receptor signaling pathway', 'signal transduction']['G protein-coupled receptor signaling pathway', 'negative regulation of signal transduction', 'regulation of G protein-coupled receptor signaling pathway', 'signal transduction']
Resistin-like beta
102
Resistin-like beta
102
7.5
77
0.17
Q99P86Q99P86['response to bacterium']['response to bacterium']
BTB/POZ domain-containing protein KCTD1
221
BTB/POZ domain-containing protein KCTD1
221
7.4
104
0.13
Q719H9Q719H9['negative regulation of transcription, DNA-templated', 'protein homooligomerization']['negative regulation of transcription, DNA-templated', 'protein homooligomerization']
Mitotic spindle assembly checkpoint protein MAD1
568
Mitotic spindle assembly checkpoint protein MAD1
568
7.5
38
0.35
Q9Y6D9Q9Y6D9['attachment of mitotic spindle microtubules to kinetochore', 'cell division', 'cytoplasmic sequestering of protein', 'deactivation of mitotic spindle assembly checkpoint', 'mitotic spindle assembly checkpoint signaling', 'negative regulation of T cell proliferation', 'positive regulation of mitotic cell cycle spindle assembly checkpoint', 'regulation of metaphase plate congression', 'thymus development']['attachment of mitotic spindle microtubules to kinetochore', 'cell division', 'cytoplasmic sequestering of protein', 'deactivation of mitotic spindle assembly checkpoint', 'mitotic spindle assembly checkpoint signaling', 'negative regulation of T cell proliferation', 'positive regulation of mitotic cell cycle spindle assembly checkpoint', 'regulation of metaphase plate congression', 'thymus development']
Pulmonary surfactant-associated protein B
298
Pulmonary surfactant-associated protein B
298
7.5
71
0.19
P50405P50405['respiratory gaseous exchange by respiratory system', 'sphingolipid metabolic process']['respiratory gaseous exchange by respiratory system', 'sphingolipid metabolic process']
Glycoprotein hormones alpha chain
55
Follitropin subunit beta
50
7.5
73
0.18
P01215P01225['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Bone morphogenetic protein 3
437
Bone morphogenetic protein 3
436
7.5
88
0.15
P12645P12645['cartilage development', 'cell-cell signaling', 'osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'skeletal system development', 'SMAD protein signal transduction']['cartilage development', 'cell-cell signaling', 'osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'skeletal system development', 'SMAD protein signal transduction']
Mineralocorticoid receptor
655
Mineralocorticoid receptor
645
8.0
72
0.17
P08235P08235['intracellular steroid hormone receptor signaling pathway', 'positive regulation of NIK/NF-kappaB signaling', 'regulation of transcription by RNA polymerase II', 'signal transduction']['intracellular steroid hormone receptor signaling pathway', 'positive regulation of NIK/NF-kappaB signaling', 'regulation of transcription by RNA polymerase II', 'signal transduction']
Protein kinase C delta type
247
Protein kinase C delta type
264
8.0
63
0.2
A0A140UHX0A0A140UHX0['apoptotic process', 'cell cycle', 'protein phosphorylation']['apoptotic process', 'cell cycle', 'protein phosphorylation']
Interleukin-10
132
Interleukin-10
132
8.0
76
0.16
P18893P18893['aging', 'branching involved in labyrinthine layer morphogenesis', 'cellular response to estradiol stimulus', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to lipopolysaccharide', 'chronic inflammatory response to antigenic stimulus', 'defense response to bacterium', 'defense response to protozoan', 'immune response', 'liver regeneration', 'negative regulation of apoptotic process', 'negative regulation of autophagy', 'negative regulation of B cell proliferation', 'negative regulation of cell population proliferation', 'negative regulation of chronic inflammatory response to antigenic stimulus', 'negative regulation of cytokine activity', 'negative regulation of cytokine production', 'negative regulation of cytokine production involved in immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of heterotypic cell-cell adhesion', 'negative regulation of hydrogen peroxide-induced neuron death', 'negative regulation of inflammatory response', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-12 production', 'negative regulation of interleukin-6 production', 'negative regulation of membrane protein ectodomain proteolysis', 'negative regulation of MHC class II biosynthetic process', 'negative regulation of myeloid dendritic cell activation', 'negative regulation of neuron apoptotic process', 'negative regulation of nitric oxide biosynthetic process', 'negative regulation of sensory perception of pain', 'negative regulation of tumor necrosis factor production', 'negative regulation of vascular associated smooth muscle cell proliferation', 'positive regulation of B cell apoptotic process', 'positive regulation of cell cycle', 'positive regulation of cytokine production', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell proliferation', 'positive regulation of immunoglobulin production', 'positive regulation of macrophage activation', 'positive regulation of MHC class II biosynthetic process', 'positive regulation of miRNA transcription', 'positive regulation of plasma cell differentiation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of signaling receptor activity', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of gene expression', 'regulation of response to wounding', 'regulation of sensory perception of pain', 'regulation of synapse organization', 'response to activity', 'response to carbon monoxide', 'response to glucocorticoid', 'response to inactivity', 'response to insulin', 'response to molecule of bacterial origin', 'response to xenobiotic stimulus']['aging', 'branching involved in labyrinthine layer morphogenesis', 'cellular response to estradiol stimulus', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to lipopolysaccharide', 'chronic inflammatory response to antigenic stimulus', 'defense response to bacterium', 'defense response to protozoan', 'immune response', 'liver regeneration', 'negative regulation of apoptotic process', 'negative regulation of autophagy', 'negative regulation of B cell proliferation', 'negative regulation of cell population proliferation', 'negative regulation of chronic inflammatory response to antigenic stimulus', 'negative regulation of cytokine activity', 'negative regulation of cytokine production', 'negative regulation of cytokine production involved in immune response', 'negative regulation of endothelial cell apoptotic process', 'negative regulation of heterotypic cell-cell adhesion', 'negative regulation of hydrogen peroxide-induced neuron death', 'negative regulation of inflammatory response', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-12 production', 'negative regulation of interleukin-6 production', 'negative regulation of membrane protein ectodomain proteolysis', 'negative regulation of MHC class II biosynthetic process', 'negative regulation of myeloid dendritic cell activation', 'negative regulation of neuron apoptotic process', 'negative regulation of nitric oxide biosynthetic process', 'negative regulation of sensory perception of pain', 'negative regulation of tumor necrosis factor production', 'negative regulation of vascular associated smooth muscle cell proliferation', 'positive regulation of B cell apoptotic process', 'positive regulation of cell cycle', 'positive regulation of cytokine production', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of endothelial cell proliferation', 'positive regulation of immunoglobulin production', 'positive regulation of macrophage activation', 'positive regulation of MHC class II biosynthetic process', 'positive regulation of miRNA transcription', 'positive regulation of plasma cell differentiation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of signaling receptor activity', 'positive regulation of sprouting angiogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of gene expression', 'regulation of response to wounding', 'regulation of sensory perception of pain', 'regulation of synapse organization', 'response to activity', 'response to carbon monoxide', 'response to glucocorticoid', 'response to inactivity', 'response to insulin', 'response to molecule of bacterial origin', 'response to xenobiotic stimulus']
Vasopressin-neurophysin 2-copeptin
110
Vasopressin-neurophysin 2-copeptin
110
8.0
98
0.13
P01180P01180['vasoconstriction']['vasoconstriction']
Bone morphogenetic protein 6
477
Bone morphogenetic protein 6
441
7.5
85
0.16
P22004P22004['BMP signaling pathway', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'cellular response to iron ion', 'cellular response to mechanical stimulus', 'endochondral ossification', 'eye development', 'immune response', 'inflammatory response', 'kidney development', 'male genitalia development', 'multicellular organismal iron ion homeostasis', 'negative regulation of adherens junction organization', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of transcription by RNA polymerase II', 'neuron differentiation', 'osteoblast differentiation', 'positive regulation of aldosterone biosynthetic process', 'positive regulation of aldosterone secretion', 'positive regulation of bone mineralization', 'positive regulation of cell population proliferation', 'positive regulation of chondrocyte differentiation', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of gene expression', 'positive regulation of lipopolysaccharide-mediated signaling pathway', 'positive regulation of neuron differentiation', 'positive regulation of osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vascular permeability', 'response to activity', 'response to glucocorticoid', 'response to magnesium ion', 'response to retinoic acid', 'skeletal system development', 'SMAD protein signal transduction', 'type B pancreatic cell development']['BMP signaling pathway', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'cellular response to iron ion', 'cellular response to mechanical stimulus', 'endochondral ossification', 'eye development', 'immune response', 'inflammatory response', 'kidney development', 'male genitalia development', 'multicellular organismal iron ion homeostasis', 'negative regulation of adherens junction organization', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of transcription by RNA polymerase II', 'neuron differentiation', 'osteoblast differentiation', 'positive regulation of aldosterone biosynthetic process', 'positive regulation of aldosterone secretion', 'positive regulation of bone mineralization', 'positive regulation of cell population proliferation', 'positive regulation of chondrocyte differentiation', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of gene expression', 'positive regulation of lipopolysaccharide-mediated signaling pathway', 'positive regulation of neuron differentiation', 'positive regulation of osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vascular permeability', 'response to activity', 'response to glucocorticoid', 'response to magnesium ion', 'response to retinoic acid', 'skeletal system development', 'SMAD protein signal transduction', 'type B pancreatic cell development']
Spondin-1
156
Spondin-1
156
8.0
68
0.18
Q9HCB6Q9HCB6['cell adhesion', 'negative regulation of amyloid-beta formation', 'positive regulation of amyloid precursor protein catabolic process', 'positive regulation of protein binding', 'positive regulation of protein processing', 'protein processing']['cell adhesion', 'negative regulation of amyloid-beta formation', 'positive regulation of amyloid precursor protein catabolic process', 'positive regulation of protein binding', 'positive regulation of protein processing', 'protein processing']
Secreted frizzled-related protein 3
147
Secreted frizzled-related protein 3
108
7.4
83
0.16
P97401P97401['canonical Wnt signaling pathway', 'cochlea morphogenesis', 'convergent extension involved in organogenesis', 'epithelial cell development', 'hepatocyte differentiation', 'inner ear morphogenesis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cartilage development', 'negative regulation of cell development', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of hepatocyte differentiation', 'negative regulation of Wnt signaling pathway', 'neural crest cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of fat cell differentiation', 'somite development']['canonical Wnt signaling pathway', 'cochlea morphogenesis', 'convergent extension involved in organogenesis', 'epithelial cell development', 'hepatocyte differentiation', 'inner ear morphogenesis', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cartilage development', 'negative regulation of cell development', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of hepatocyte differentiation', 'negative regulation of Wnt signaling pathway', 'neural crest cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of fat cell differentiation', 'somite development']
Neutrophil elastase
55
Antileukoproteinase
96
8.0
94
0.13
P08246P03973['acute inflammatory response to antigenic stimulus', 'biosynthetic process of antibacterial peptides active against Gram-negative bacteria', 'cellular calcium ion homeostasis', 'defense response to bacterium', 'extracellular matrix disassembly', 'leukocyte migration involved in inflammatory response', 'negative regulation of chemokine production', 'negative regulation of chemotaxis', 'negative regulation of inflammatory response', 'negative regulation of interleukin-8 production', 'negative regulation of transcription by RNA polymerase II', 'neutrophil-mediated killing of fungus', 'neutrophil-mediated killing of gram-negative bacterium', 'phagocytosis', 'positive regulation of immune response', 'positive regulation of interleukin-8 production', 'positive regulation of leukocyte tethering or rolling', 'positive regulation of MAP kinase activity', 'positive regulation of smooth muscle cell proliferation', 'protein catabolic process', 'proteolysis', 'pyroptosis', 'response to lipopolysaccharide', 'response to UV', 'response to yeast']['antibacterial humoral response', 'immune response', 'innate immune response', 'modulation of process of another organism', 'negative regulation of protein binding', 'negative regulation of viral genome replication', 'response to lipopolysaccharide']
E3 ubiquitin-protein ligase RNF13
281
E3 ubiquitin-protein ligase RNF13
266
8.0
68
0.19
O43567O43567['organelle localization', 'positive regulation of stress-activated protein kinase signaling cascade', 'protein autoubiquitination', 'ubiquitin-dependent protein catabolic process']['organelle localization', 'positive regulation of stress-activated protein kinase signaling cascade', 'protein autoubiquitination', 'ubiquitin-dependent protein catabolic process']
Uromodulin
425
Uromodulin
425
8.0
94
0.13
P07911P07911['apoptotic signaling pathway', 'autophagy', 'cellular calcium ion homeostasis', 'cellular chloride ion homeostasis', 'cellular defense response', 'cellular phosphate ion homeostasis', 'cellular response to unfolded protein', 'cellular sodium ion homeostasis', 'chaperone-mediated protein folding', 'citric acid secretion', 'collecting duct development', 'connective tissue replacement', 'creatinine homeostasis', 'defense response to Gram-negative bacterium', 'endoplasmic reticulum organization', 'glomerular filtration', 'heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules', 'inflammatory response', 'juxtaglomerular apparatus development', 'leukocyte cell-cell adhesion', 'lipid metabolic process', 'metanephric ascending thin limb development', 'metanephric distal convoluted tubule development', 'metanephric thick ascending limb development', 'micturition', 'multicellular organismal response to stress', 'negative regulation of cell population proliferation', 'neutrophil migration', 'organ or tissue specific immune response', 'peptidyl-threonine phosphorylation', 'potassium ion homeostasis', 'protein localization to vacuole', 'protein transport into plasma membrane raft', 'regulation of blood pressure', 'regulation of protein transport', 'regulation of urine volume', 'renal sodium ion absorption', 'renal urate salt excretion', 'renal water homeostasis', 'response to lipopolysaccharide', 'response to water deprivation', 'response to xenobiotic stimulus', 'RNA splicing', 'tumor necrosis factor-mediated signaling pathway', 'ubiquitin-dependent ERAD pathway', 'urate transport', 'urea transmembrane transport']['apoptotic signaling pathway', 'autophagy', 'cellular calcium ion homeostasis', 'cellular chloride ion homeostasis', 'cellular defense response', 'cellular phosphate ion homeostasis', 'cellular response to unfolded protein', 'cellular sodium ion homeostasis', 'chaperone-mediated protein folding', 'citric acid secretion', 'collecting duct development', 'connective tissue replacement', 'creatinine homeostasis', 'defense response to Gram-negative bacterium', 'endoplasmic reticulum organization', 'glomerular filtration', 'heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules', 'inflammatory response', 'juxtaglomerular apparatus development', 'leukocyte cell-cell adhesion', 'lipid metabolic process', 'metanephric ascending thin limb development', 'metanephric distal convoluted tubule development', 'metanephric thick ascending limb development', 'micturition', 'multicellular organismal response to stress', 'negative regulation of cell population proliferation', 'neutrophil migration', 'organ or tissue specific immune response', 'peptidyl-threonine phosphorylation', 'potassium ion homeostasis', 'protein localization to vacuole', 'protein transport into plasma membrane raft', 'regulation of blood pressure', 'regulation of protein transport', 'regulation of urine volume', 'renal sodium ion absorption', 'renal urate salt excretion', 'renal water homeostasis', 'response to lipopolysaccharide', 'response to water deprivation', 'response to xenobiotic stimulus', 'RNA splicing', 'tumor necrosis factor-mediated signaling pathway', 'ubiquitin-dependent ERAD pathway', 'urate transport', 'urea transmembrane transport']
Origin recognition complex subunit 1
829
Origin recognition complex subunit 4
194
7.7
81
0.16
Q13415O43929['DNA replication initiation', 'mitotic DNA replication checkpoint signaling']['DNA replication initiation']
Glycoprotein hormones alpha chain
55
Follitropin subunit beta
102
7.9
70
0.18
P01215P01225['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Hepatocyte growth factor activator
448
Kunitz-type protease inhibitor 1
259
7.9
96
0.13
Q04756O43278['blood coagulation', 'proteolysis', 'zymogen activation']['branching involved in labyrinthine layer morphogenesis', 'cellular response to BMP stimulus', 'epidermis development', 'epithelium development', 'extracellular matrix organization', 'negative regulation of neural precursor cell proliferation', 'neural tube closure', 'placenta blood vessel development', 'positive regulation of glial cell differentiation']
Dual specificity protein phosphatase 15
73
Dual specificity protein phosphatase 15
73
7.9
68
0.19
Q5QP65Q5QP65['dephosphorylation', 'protein dephosphorylation', 'regulation of oligodendrocyte differentiation', 'signal transduction']['dephosphorylation', 'protein dephosphorylation', 'regulation of oligodendrocyte differentiation', 'signal transduction']
Bone morphogenetic protein 3
403
Bone morphogenetic protein 3
436
7.9
85
0.15
P12645P12645['cartilage development', 'cell-cell signaling', 'osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'skeletal system development', 'SMAD protein signal transduction']['cartilage development', 'cell-cell signaling', 'osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'skeletal system development', 'SMAD protein signal transduction']
NACHT, LRR and PYD domains-containing protein 1 allele 2
866
NACHT, LRR and PYD domains-containing protein 1 allele 2
1013
7.8
67
0.19
D9I2G3D9I2G3['inflammatory response', 'innate immune response', 'programmed cell death', 'proteolysis', 'regulation of apoptotic process']['inflammatory response', 'innate immune response', 'programmed cell death', 'proteolysis', 'regulation of apoptotic process']
Trypsin
33
Antileukoproteinase
96
7.8
96
0.13
P00761P03973['digestion', 'proteolysis']['antibacterial humoral response', 'immune response', 'innate immune response', 'modulation of process of another organism', 'negative regulation of protein binding', 'negative regulation of viral genome replication', 'response to lipopolysaccharide']
C-C motif chemokine 1
57
C-C motif chemokine 1
57
7.8
46
0.28
P22362P22362['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of inflammatory response', 'positive regulation of interleukin-17 production', 'positive regulation of monocyte chemotaxis', 'signal transduction', 'viral process']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of inflammatory response', 'positive regulation of interleukin-17 production', 'positive regulation of monocyte chemotaxis', 'signal transduction', 'viral process']
E3 ubiquitin-protein ligase parkin
360
E3 ubiquitin-protein ligase parkin
323
7.8
73
0.18
Q9JK66Q9JK66['adult locomotory behavior', 'aggresome assembly', 'autophagy of mitochondrion', 'brain development', 'cellular response to hydrogen sulfide', 'cellular response to L-glutamate', 'cellular response to L-glutamine', 'cellular response to manganese ion', 'cellular response to toxic substance', 'dopamine metabolic process', 'dopamine uptake involved in synaptic transmission', 'free ubiquitin chain polymerization', 'learning', 'locomotory behavior', 'mitochondrial fission', 'mitochondrial fragmentation involved in apoptotic process', 'mitochondrion localization', 'mitochondrion organization', 'mitochondrion to lysosome transport', 'mitophagy', 'modulation of chemical synaptic transmission', 'negative regulation by host of viral genome replication', 'negative regulation of actin filament bundle assembly', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell death', 'negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of excitatory postsynaptic potential', 'negative regulation of exosomal secretion', 'negative regulation of gene expression', 'negative regulation of glucokinase activity', 'negative regulation of insulin secretion', 'negative regulation of intralumenal vesicle formation', 'negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'negative regulation of JNK cascade', 'negative regulation of mitochondrial fission', 'negative regulation of mitochondrial fusion', 'negative regulation of neuron apoptotic process', 'negative regulation of neuron death', 'negative regulation of oxidative stress-induced neuron death', 'negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of primary amine oxidase activity', 'negative regulation of protein phosphorylation', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of release of cytochrome c from mitochondria', 'negative regulation of spontaneous neurotransmitter secretion', 'negative regulation of synaptic transmission, glutamatergic', 'negative regulation of transcription by RNA polymerase II', 'neuron cellular homeostasis', 'norepinephrine metabolic process', 'parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization', 'positive regulation of apoptotic process', 'positive regulation of ATP biosynthetic process', 'positive regulation of autophagy of mitochondrion', 'positive regulation of dendrite extension', 'positive regulation of DNA binding', 'positive regulation of gene expression', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of mitochondrial fission', 'positive regulation of mitochondrial fusion', 'positive regulation of mitochondrial membrane potential', 'positive regulation of mitophagy', 'positive regulation of mitophagy in response to mitochondrial depolarization', 'positive regulation of neurotransmitter uptake', 'positive regulation of proteasomal protein catabolic process', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of protein binding', 'positive regulation of protein linear polyubiquitination', 'positive regulation of protein localization to membrane', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor-mediated signaling pathway', 'proteasomal protein catabolic process', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein autoubiquitination', 'protein destabilization', 'protein K11-linked ubiquitination', 'protein K48-linked ubiquitination', 'protein K6-linked ubiquitination', 'protein K63-linked ubiquitination', 'protein localization to mitochondrion', 'protein metabolic process', 'protein monoubiquitination', 'protein polyubiquitination', 'protein stabilization', 'protein ubiquitination', 'regulation of apoptotic process', 'regulation of autophagy', 'regulation of cellular response to oxidative stress', 'regulation of dopamine metabolic process', 'regulation of gene expression', 'regulation of mitochondrial membrane potential', 'regulation of mitochondrion organization', 'regulation of neurotransmitter secretion', 'regulation of protein stability', 'regulation of protein ubiquitination', 'regulation of reactive oxygen species metabolic process', 'response to corticosterone', 'response to curcumin', 'response to endoplasmic reticulum stress', 'response to muscle activity', 'response to oxidative stress', 'response to unfolded protein', 'response to xenobiotic stimulus', 'startle response', 'synaptic transmission, dopaminergic', 'synaptic transmission, glutamatergic', 'ubiquitin-dependent protein catabolic process', 'zinc ion homeostasis']['adult locomotory behavior', 'aggresome assembly', 'autophagy of mitochondrion', 'brain development', 'cellular response to hydrogen sulfide', 'cellular response to L-glutamate', 'cellular response to L-glutamine', 'cellular response to manganese ion', 'cellular response to toxic substance', 'dopamine metabolic process', 'dopamine uptake involved in synaptic transmission', 'free ubiquitin chain polymerization', 'learning', 'locomotory behavior', 'mitochondrial fission', 'mitochondrial fragmentation involved in apoptotic process', 'mitochondrion localization', 'mitochondrion organization', 'mitochondrion to lysosome transport', 'mitophagy', 'modulation of chemical synaptic transmission', 'negative regulation by host of viral genome replication', 'negative regulation of actin filament bundle assembly', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell death', 'negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of excitatory postsynaptic potential', 'negative regulation of exosomal secretion', 'negative regulation of gene expression', 'negative regulation of glucokinase activity', 'negative regulation of insulin secretion', 'negative regulation of intralumenal vesicle formation', 'negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'negative regulation of JNK cascade', 'negative regulation of mitochondrial fission', 'negative regulation of mitochondrial fusion', 'negative regulation of neuron apoptotic process', 'negative regulation of neuron death', 'negative regulation of oxidative stress-induced neuron death', 'negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of primary amine oxidase activity', 'negative regulation of protein phosphorylation', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of release of cytochrome c from mitochondria', 'negative regulation of spontaneous neurotransmitter secretion', 'negative regulation of synaptic transmission, glutamatergic', 'negative regulation of transcription by RNA polymerase II', 'neuron cellular homeostasis', 'norepinephrine metabolic process', 'parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization', 'positive regulation of apoptotic process', 'positive regulation of ATP biosynthetic process', 'positive regulation of autophagy of mitochondrion', 'positive regulation of dendrite extension', 'positive regulation of DNA binding', 'positive regulation of gene expression', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of mitochondrial fission', 'positive regulation of mitochondrial fusion', 'positive regulation of mitochondrial membrane potential', 'positive regulation of mitophagy', 'positive regulation of mitophagy in response to mitochondrial depolarization', 'positive regulation of neurotransmitter uptake', 'positive regulation of proteasomal protein catabolic process', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of protein binding', 'positive regulation of protein linear polyubiquitination', 'positive regulation of protein localization to membrane', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor-mediated signaling pathway', 'proteasomal protein catabolic process', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein autoubiquitination', 'protein destabilization', 'protein K11-linked ubiquitination', 'protein K48-linked ubiquitination', 'protein K6-linked ubiquitination', 'protein K63-linked ubiquitination', 'protein localization to mitochondrion', 'protein metabolic process', 'protein monoubiquitination', 'protein polyubiquitination', 'protein stabilization', 'protein ubiquitination', 'regulation of apoptotic process', 'regulation of autophagy', 'regulation of cellular response to oxidative stress', 'regulation of dopamine metabolic process', 'regulation of gene expression', 'regulation of mitochondrial membrane potential', 'regulation of mitochondrion organization', 'regulation of neurotransmitter secretion', 'regulation of protein stability', 'regulation of protein ubiquitination', 'regulation of reactive oxygen species metabolic process', 'response to corticosterone', 'response to curcumin', 'response to endoplasmic reticulum stress', 'response to muscle activity', 'response to oxidative stress', 'response to unfolded protein', 'response to xenobiotic stimulus', 'startle response', 'synaptic transmission, dopaminergic', 'synaptic transmission, glutamatergic', 'ubiquitin-dependent protein catabolic process', 'zinc ion homeostasis']
Ceramide transfer protein
27
Ceramide transfer protein
27
7.9
74
0.17
Q9Y5P4Q9Y5P4['cell morphogenesis', 'cell population proliferation', 'ceramide metabolic process', 'ceramide transport', 'endoplasmic reticulum organization', 'ER to Golgi ceramide transport', 'heart morphogenesis', 'immune response', 'in utero embryonic development', 'intermembrane lipid transfer', 'intermembrane sphingolipid transfer', 'lipid homeostasis', 'mitochondrion morphogenesis', 'muscle contraction', 'response to endoplasmic reticulum stress', 'signal transduction']['cell morphogenesis', 'cell population proliferation', 'ceramide metabolic process', 'ceramide transport', 'endoplasmic reticulum organization', 'ER to Golgi ceramide transport', 'heart morphogenesis', 'immune response', 'in utero embryonic development', 'intermembrane lipid transfer', 'intermembrane sphingolipid transfer', 'lipid homeostasis', 'mitochondrion morphogenesis', 'muscle contraction', 'response to endoplasmic reticulum stress', 'signal transduction']
Probable ubiquitin carboxyl-terminal hydrolase FAF-X
1733
Probable ubiquitin carboxyl-terminal hydrolase FAF-X
1733
7.9
43
0.3
Q93008Q93008['amyloid fibril formation', 'axon extension', 'BMP signaling pathway', 'cell cycle', 'cell division', 'cell migration', 'chromosome segregation', 'female gamete generation', 'negative regulation of proteasomal ubiquitin-dependent protein catabolic process', 'negative regulation of transcription by RNA polymerase II', 'neuron migration', 'positive regulation of DNA demethylation', 'positive regulation of protein binding', 'positive regulation of TORC2 signaling', 'protein deubiquitination', 'protein deubiquitination involved in ubiquitin-dependent protein catabolic process', 'protein K63-linked deubiquitination', 'protein localization', 'protein stabilization', 'protein ubiquitination', 'regulation of circadian rhythm', 'rhythmic process', 'transforming growth factor beta receptor signaling pathway']['amyloid fibril formation', 'axon extension', 'BMP signaling pathway', 'cell cycle', 'cell division', 'cell migration', 'chromosome segregation', 'female gamete generation', 'negative regulation of proteasomal ubiquitin-dependent protein catabolic process', 'negative regulation of transcription by RNA polymerase II', 'neuron migration', 'positive regulation of DNA demethylation', 'positive regulation of protein binding', 'positive regulation of TORC2 signaling', 'protein deubiquitination', 'protein deubiquitination involved in ubiquitin-dependent protein catabolic process', 'protein K63-linked deubiquitination', 'protein localization', 'protein stabilization', 'protein ubiquitination', 'regulation of circadian rhythm', 'rhythmic process', 'transforming growth factor beta receptor signaling pathway']
NACHT, LRR and PYD domains-containing protein 1 allele 2
1064
NACHT, LRR and PYD domains-containing protein 1 allele 2
1064
7.9
76
0.17
D9I2G3D9I2G3['inflammatory response', 'innate immune response', 'programmed cell death', 'proteolysis', 'regulation of apoptotic process']['inflammatory response', 'innate immune response', 'programmed cell death', 'proteolysis', 'regulation of apoptotic process']
MIT domain-containing protein 1
226
MIT domain-containing protein 1
226
7.7
68
0.19
Q8WV92Q8WV92['midbody abscission', 'mitotic cytokinesis', 'negative regulation of protein binding']['midbody abscission', 'mitotic cytokinesis', 'negative regulation of protein binding']
Glycoprotein hormones alpha chain
55
Follitropin subunit beta
50
7.7
79
0.16
Q96QJ4P01225[]['female gamete generation', 'female pregnancy', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'positive regulation of bone resorption', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of gene expression', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'progesterone biosynthetic process', 'regulation of osteoclast differentiation', 'regulation of signaling receptor activity', 'Sertoli cell proliferation', 'spermatogenesis', 'transforming growth factor beta receptor signaling pathway']
Protein disulfide-isomerase
397
Microsomal triglyceride transfer protein large subunit
866
7.7
72
0.18
P07237P55157['cellular response to hypoxia', 'cellular response to interleukin-7', 'interleukin-12-mediated signaling pathway', 'interleukin-23-mediated signaling pathway', 'peptidyl-proline hydroxylation to 4-hydroxy-L-proline', 'positive regulation of cell adhesion', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of viral entry into host cell', 'protein folding', 'protein folding in endoplasmic reticulum', 'regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'response to endoplasmic reticulum stress']['cholesterol homeostasis', 'chylomicron assembly', 'circadian rhythm', 'establishment of localization in cell', 'lipid metabolic process', 'lipoprotein metabolic process', 'lipoprotein transport', 'low-density lipoprotein particle remodeling', 'phospholipid transport', 'plasma lipoprotein particle assembly', 'protein lipidation', 'protein secretion', 'response to calcium ion', 'triglyceride metabolic process', 'triglyceride transport', 'very-low-density lipoprotein particle assembly']
Interleukin enhancer-binding factor 2
37
Interleukin enhancer-binding factor 3
278
7.7
75
0.17
Q9CXY6Q9Z1X4['positive regulation of transcription, DNA-templated']['defense response to virus', 'negative regulation of transcription, DNA-templated', 'negative regulation of translation', 'negative regulation of viral genome replication', 'positive regulation of transcription, DNA-templated', 'protein methylation', 'protein phosphorylation']
Chymotrypsin-like elastase family member 1
72
Elafin
109
7.8
90
0.14
P00772P19957['proteolysis']['antibacterial humoral response', 'copulation', 'innate immune response', 'peptide cross-linking']
MIT domain-containing protein 1
37
MIT domain-containing protein 1
37
6.5
93
0.17
Q8WV92Q8WV92['midbody abscission', 'mitotic cytokinesis', 'negative regulation of protein binding']['midbody abscission', 'mitotic cytokinesis', 'negative regulation of protein binding']
Mothers against decapentaplegic homolog 3
332
Zinc finger FYVE domain-containing protein 9
783
6.5
79
0.2
P84022O95405['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'activin receptor signaling pathway', 'adrenal gland development', 'anatomical structure morphogenesis', 'BMP signaling pathway', 'cell differentiation', 'cell-cell junction organization', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'developmental growth', 'embryonic cranial skeleton morphogenesis', 'embryonic foregut morphogenesis', 'embryonic pattern specification', 'endoderm development', 'extrinsic apoptotic signaling pathway', 'heart looping', 'immune response', 'immune system development', 'in utero embryonic development', 'JNK cascade', 'lens fiber cell differentiation', 'liver development', 'mesoderm formation', 'negative regulation of apoptotic process', 'negative regulation of cardiac muscle hypertrophy in response to stress', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cytosolic calcium ion concentration', 'negative regulation of fat cell differentiation', 'negative regulation of inflammatory response', 'negative regulation of lung blood pressure', 'negative regulation of osteoblast differentiation', 'negative regulation of osteoblast proliferation', 'negative regulation of protein catabolic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of wound healing', 'nodal signaling pathway', 'osteoblast development', 'paraxial mesoderm morphogenesis', 'pericardium development', 'positive regulation of alkaline phosphatase activity', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cell migration', 'positive regulation of chondrocyte differentiation', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of extracellular matrix assembly', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of interleukin-1 beta production', 'positive regulation of miRNA transcription', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of positive chemotaxis', 'positive regulation of protein import into nucleus', 'positive regulation of stress fiber assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta3 production', 'primary miRNA processing', 'protein stabilization', 'regulation of binding', 'regulation of epithelial cell proliferation', 'regulation of immune response', 'regulation of miRNA transcription', 'regulation of striated muscle tissue development', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'signal transduction involved in regulation of gene expression', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'somitogenesis', 'T cell activation', 'thyroid gland development', 'transdifferentiation', 'transforming growth factor beta receptor signaling pathway', 'ureteric bud development', 'wound healing']['endocytosis', 'endosomal transport', 'transforming growth factor beta receptor signaling pathway']
G-protein-signaling modulator 2
604
G-protein-signaling modulator 2
125
7.8
72
0.18
Q8VDU0Q8VDU0['cell division', 'establishment of mitotic spindle orientation', 'maintenance of centrosome location', 'mitotic spindle organization', 'positive regulation of protein localization to cell cortex', 'positive regulation of spindle assembly', 'Ran protein signal transduction', 'regulation of mitotic spindle organization']['cell division', 'establishment of mitotic spindle orientation', 'maintenance of centrosome location', 'mitotic spindle organization', 'positive regulation of protein localization to cell cortex', 'positive regulation of spindle assembly', 'Ran protein signal transduction', 'regulation of mitotic spindle organization']
Defensin beta 4A
38
Defensin beta 4A
38
6.5
99
0.16
O15263O15263['antifungal innate immune response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell chemotaxis', 'chemotaxis', 'defense response to bacterium', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'G protein-coupled receptor signaling pathway', 'immune response', 'killing of cells of another organism', 'membrane disruption in another organism']['antifungal innate immune response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell chemotaxis', 'chemotaxis', 'defense response to bacterium', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'G protein-coupled receptor signaling pathway', 'immune response', 'killing of cells of another organism', 'membrane disruption in another organism']
Exocyst complex component 8
202
Exocyst complex component 8
202
6.5
74
0.21
O54924O54924['endosome organization', 'exocytosis', 'extracellular matrix disassembly', 'Golgi to plasma membrane transport', 'protein localization', 'protein transport']['endosome organization', 'exocytosis', 'extracellular matrix disassembly', 'Golgi to plasma membrane transport', 'protein localization', 'protein transport']
cAMP-dependent protein kinase type I-beta regulatory subunit
34
cAMP-dependent protein kinase type I-beta regulatory subunit
34
7.8
57
0.23
P31321P31321['learning or memory', 'negative regulation of cAMP-dependent protein kinase activity', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of fear response', 'positive regulation of long-term synaptic potentiation', 'positive regulation of sensory perception of pain', 'protein phosphorylation', 'regulation of synaptic vesicle cycle']['learning or memory', 'negative regulation of cAMP-dependent protein kinase activity', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of fear response', 'positive regulation of long-term synaptic potentiation', 'positive regulation of sensory perception of pain', 'protein phosphorylation', 'regulation of synaptic vesicle cycle']
Neutrophil elastase
71
Antileukoproteinase
96
7.8
95
0.13
P08246P03973['acute inflammatory response to antigenic stimulus', 'biosynthetic process of antibacterial peptides active against Gram-negative bacteria', 'cellular calcium ion homeostasis', 'defense response to bacterium', 'extracellular matrix disassembly', 'leukocyte migration involved in inflammatory response', 'negative regulation of chemokine production', 'negative regulation of chemotaxis', 'negative regulation of inflammatory response', 'negative regulation of interleukin-8 production', 'negative regulation of transcription by RNA polymerase II', 'neutrophil-mediated killing of fungus', 'neutrophil-mediated killing of gram-negative bacterium', 'phagocytosis', 'positive regulation of immune response', 'positive regulation of interleukin-8 production', 'positive regulation of leukocyte tethering or rolling', 'positive regulation of MAP kinase activity', 'positive regulation of smooth muscle cell proliferation', 'protein catabolic process', 'proteolysis', 'pyroptosis', 'response to lipopolysaccharide', 'response to UV', 'response to yeast']['antibacterial humoral response', 'immune response', 'innate immune response', 'modulation of process of another organism', 'negative regulation of protein binding', 'negative regulation of viral genome replication', 'response to lipopolysaccharide']
Brain-derived neurotrophic factor
239
Neurotrophin-3
248
7.7
90
0.14
P23560P20783['axon guidance', 'brain-derived neurotrophic factor receptor signaling pathway', 'collateral sprouting', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of apoptotic signaling pathway', 'negative regulation of myotube differentiation', 'negative regulation of neuron apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'nervous system development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of brain-derived neurotrophic factor receptor signaling pathway', 'positive regulation of collateral sprouting', 'positive regulation of neuron projection development', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of receptor binding', 'positive regulation of synapse assembly', 'regulation of neuron differentiation', 'regulation of protein localization to cell surface', 'synapse assembly', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of GTPase activity', 'activation of protein kinase B activity', 'cell-cell signaling', 'induction of positive chemotaxis', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of peptidyl-tyrosine phosphorylation', 'nerve development', 'nerve growth factor signaling pathway', 'nervous system development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of MAP kinase activity', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of receptor internalization', 'regulation of apoptotic process', 'regulation of neuron differentiation', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Lethal(3)malignant brain tumor-like protein 2
531
Lethal(3)malignant brain tumor-like protein 2
531
7.8
53
0.24
Q969R5Q969R5['chromatin organization', 'negative regulation of transcription, DNA-templated']['chromatin organization', 'negative regulation of transcription, DNA-templated']
Protein S100-A3
23
Protein S100-A3
83
7.8
80
0.16
P33764P33764[][]
Neurotrophin-3
248
Neurotrophin-3
248
7.7
90
0.14
P20783P20783['activation of GTPase activity', 'activation of protein kinase B activity', 'cell-cell signaling', 'induction of positive chemotaxis', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of peptidyl-tyrosine phosphorylation', 'nerve development', 'nerve growth factor signaling pathway', 'nervous system development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of MAP kinase activity', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of receptor internalization', 'regulation of apoptotic process', 'regulation of neuron differentiation', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of GTPase activity', 'activation of protein kinase B activity', 'cell-cell signaling', 'induction of positive chemotaxis', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of peptidyl-tyrosine phosphorylation', 'nerve development', 'nerve growth factor signaling pathway', 'nervous system development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of MAP kinase activity', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of receptor internalization', 'regulation of apoptotic process', 'regulation of neuron differentiation', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Proteasome subunit beta type-10
70
Proteasome subunit beta type-3
129
8.0
70
0.18
O35955Q9R1P1['cell morphogenesis', 'proteasomal protein catabolic process', 'T cell proliferation']['proteasomal protein catabolic process', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein catabolic process']
C-C motif chemokine 8
34
C-C motif chemokine 8
59
8.0
65
0.19
P80075P80075['antimicrobial humoral immune response mediated by antimicrobial peptide', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation by host of viral genome replication', 'negative regulation of leukocyte proliferation', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of leukocyte migration', 'response to virus', 'signal transduction']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation by host of viral genome replication', 'negative regulation of leukocyte proliferation', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of leukocyte migration', 'response to virus', 'signal transduction']
Ras-related protein Rab-8A
123
Ras-related protein Rab-8A
123
8.0
86
0.14
P61006P61006['autophagy', 'axonogenesis', 'cellular response to insulin stimulus', 'cilium assembly', 'endocytic recycling', 'Golgi organization', 'Golgi vesicle fusion to target membrane', 'neurotransmitter receptor transport to postsynaptic membrane', 'neurotransmitter receptor transport, endosome to postsynaptic membrane', 'protein localization to cilium', 'protein localization to plasma membrane', 'protein secretion', 'regulation of autophagy', 'regulation of exocytosis', 'regulation of long-term neuronal synaptic plasticity', 'regulation of protein transport', 'vesicle docking involved in exocytosis', 'vesicle-mediated transport in synapse']['autophagy', 'axonogenesis', 'cellular response to insulin stimulus', 'cilium assembly', 'endocytic recycling', 'Golgi organization', 'Golgi vesicle fusion to target membrane', 'neurotransmitter receptor transport to postsynaptic membrane', 'neurotransmitter receptor transport, endosome to postsynaptic membrane', 'protein localization to cilium', 'protein localization to plasma membrane', 'protein secretion', 'regulation of autophagy', 'regulation of exocytosis', 'regulation of long-term neuronal synaptic plasticity', 'regulation of protein transport', 'vesicle docking involved in exocytosis', 'vesicle-mediated transport in synapse']
Protein kinase C delta type
264
Protein kinase C delta type
272
7.8
66
0.2
A0A140UHX0A0A140UHX0['apoptotic process', 'cell cycle', 'protein phosphorylation']['apoptotic process', 'cell cycle', 'protein phosphorylation']
Progesterone receptor
619
Progesterone receptor
609
7.7
74
0.18
P06401P06401['cell-cell signaling', 'glandular epithelial cell maturation', 'intracellular steroid hormone receptor signaling pathway', 'lung alveolus development', 'negative regulation of gene expression', 'ovulation from ovarian follicle', 'paracrine signaling', 'positive regulation of gene expression', 'positive regulation of transcription by RNA polymerase II', 'progesterone receptor signaling pathway', 'regulation of epithelial cell proliferation', 'regulation of transcription by RNA polymerase II', 'signal transduction', 'tertiary branching involved in mammary gland duct morphogenesis']['cell-cell signaling', 'glandular epithelial cell maturation', 'intracellular steroid hormone receptor signaling pathway', 'lung alveolus development', 'negative regulation of gene expression', 'ovulation from ovarian follicle', 'paracrine signaling', 'positive regulation of gene expression', 'positive regulation of transcription by RNA polymerase II', 'progesterone receptor signaling pathway', 'regulation of epithelial cell proliferation', 'regulation of transcription by RNA polymerase II', 'signal transduction', 'tertiary branching involved in mammary gland duct morphogenesis']
Trypsin
49
Antileukoproteinase
122
7.7
86
0.15
P00761P03973['digestion', 'proteolysis']['antibacterial humoral response', 'immune response', 'innate immune response', 'modulation of process of another organism', 'negative regulation of protein binding', 'negative regulation of viral genome replication', 'response to lipopolysaccharide']
Polyunsaturated fatty acid 5-lipoxygenase
301
Polyunsaturated fatty acid 5-lipoxygenase
450
7.7
55
0.24
P09917P09917['arachidonic acid metabolic process', 'dendritic cell migration', 'glucose homeostasis', 'hepoxilin biosynthetic process', 'humoral immune response', 'leukocyte chemotaxis involved in inflammatory response', 'leukocyte migration involved in inflammatory response', 'leukotriene A4 biosynthetic process', 'leukotriene biosynthetic process', 'leukotriene metabolic process', 'leukotriene production involved in inflammatory response', 'linoleic acid metabolic process', 'lipid oxidation', 'lipoxin biosynthetic process', 'lipoxygenase pathway', 'long-chain fatty acid biosynthetic process', 'negative regulation of angiogenesis', 'negative regulation of endothelial cell proliferation', 'negative regulation of inflammatory response', 'negative regulation of response to endoplasmic reticulum stress', 'negative regulation of sprouting angiogenesis', 'negative regulation of vascular wound healing', 'negative regulation of wound healing', 'positive regulation of bone mineralization', 'positive regulation of leukocyte adhesion to arterial endothelial cell', 'regulation of cellular response to oxidative stress', 'regulation of cytokine production involved in inflammatory response', 'regulation of fat cell differentiation', 'regulation of inflammatory response', 'regulation of inflammatory response to wounding', 'regulation of insulin secretion', 'regulation of reactive oxygen species biosynthetic process']['arachidonic acid metabolic process', 'dendritic cell migration', 'glucose homeostasis', 'hepoxilin biosynthetic process', 'humoral immune response', 'leukocyte chemotaxis involved in inflammatory response', 'leukocyte migration involved in inflammatory response', 'leukotriene A4 biosynthetic process', 'leukotriene biosynthetic process', 'leukotriene metabolic process', 'leukotriene production involved in inflammatory response', 'linoleic acid metabolic process', 'lipid oxidation', 'lipoxin biosynthetic process', 'lipoxygenase pathway', 'long-chain fatty acid biosynthetic process', 'negative regulation of angiogenesis', 'negative regulation of endothelial cell proliferation', 'negative regulation of inflammatory response', 'negative regulation of response to endoplasmic reticulum stress', 'negative regulation of sprouting angiogenesis', 'negative regulation of vascular wound healing', 'negative regulation of wound healing', 'positive regulation of bone mineralization', 'positive regulation of leukocyte adhesion to arterial endothelial cell', 'regulation of cellular response to oxidative stress', 'regulation of cytokine production involved in inflammatory response', 'regulation of fat cell differentiation', 'regulation of inflammatory response', 'regulation of inflammatory response to wounding', 'regulation of insulin secretion', 'regulation of reactive oxygen species biosynthetic process']
Trypsin
49
Antileukoproteinase
96
7.7
94
0.14
P00761P03973['digestion', 'proteolysis']['antibacterial humoral response', 'immune response', 'innate immune response', 'modulation of process of another organism', 'negative regulation of protein binding', 'negative regulation of viral genome replication', 'response to lipopolysaccharide']
Importin subunit alpha
419
Importin subunit alpha
419
7.8
70
0.18
H0VVB1H0VVB1['entry of viral genome into host nucleus through nuclear pore complex via importin', 'NLS-bearing protein import into nucleus', 'positive regulation of viral life cycle', 'postsynapse to nucleus signaling pathway']['entry of viral genome into host nucleus through nuclear pore complex via importin', 'NLS-bearing protein import into nucleus', 'positive regulation of viral life cycle', 'postsynapse to nucleus signaling pathway']
Microcephalin
776
Microcephalin
776
7.8
85
0.15
Q8NEM0Q8NEM0['bone development', 'cerebral cortex development', 'establishment of mitotic spindle orientation', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'neuronal stem cell population maintenance', 'protein localization to centrosome', 'regulation of centrosome cycle', 'regulation of chromosome condensation', 'regulation of inflammatory response', 'regulation of kinase activity']['bone development', 'cerebral cortex development', 'establishment of mitotic spindle orientation', 'mitotic cell cycle', 'negative regulation of transcription by RNA polymerase II', 'neuronal stem cell population maintenance', 'protein localization to centrosome', 'regulation of centrosome cycle', 'regulation of chromosome condensation', 'regulation of inflammatory response', 'regulation of kinase activity']
Sodium channel subunit beta-4
58
Sodium channel subunit beta-4
58
2.0
40
1.23
Q7M729Q7M729['AV node cell action potential', 'cardiac muscle cell action potential involved in contraction', 'cardiac muscle contraction', 'establishment of localization in cell', 'membrane depolarization during cardiac muscle cell action potential', 'positive regulation of sodium ion transport', 'regulation of heart rate by cardiac conduction', 'regulation of sodium ion transmembrane transporter activity', 'regulation of ventricular cardiac muscle cell membrane repolarization', 'sodium ion transmembrane transport', 'sodium ion transport']['AV node cell action potential', 'cardiac muscle cell action potential involved in contraction', 'cardiac muscle contraction', 'establishment of localization in cell', 'membrane depolarization during cardiac muscle cell action potential', 'positive regulation of sodium ion transport', 'regulation of heart rate by cardiac conduction', 'regulation of sodium ion transmembrane transporter activity', 'regulation of ventricular cardiac muscle cell membrane repolarization', 'sodium ion transmembrane transport', 'sodium ion transport']
Ig gamma-2A chain C region, A allele
112
Ig gamma-2A chain C region, A allele
112
2.0
35
1.4
P01863P01863['B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'response to bacterium']['B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'response to bacterium']
Myc proto-oncogene protein
438
Myc proto-oncogene protein
438
2.0
26
1.89
P01106P01106['branching involved in ureteric bud morphogenesis', 'cellular iron ion homeostasis', 'cellular response to DNA damage stimulus', 'cellular response to hypoxia', 'cellular response to UV', 'cellular response to xenobiotic stimulus', 'chromatin remodeling', 'chromosome organization', 'energy reserve metabolic process', 'ERK1 and ERK2 cascade', 'fibroblast apoptotic process', 'G1/S transition of mitotic cell cycle', 'MAPK cascade', 'negative regulation of apoptotic process', 'negative regulation of cell division', 'negative regulation of fibroblast proliferation', 'negative regulation of monocyte differentiation', 'negative regulation of stress-activated MAPK cascade', 'negative regulation of transcription by RNA polymerase II', 'oxygen transport', 'positive regulation of cell population proliferation', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of DNA biosynthetic process', 'positive regulation of DNA methylation', 'positive regulation of epithelial cell proliferation', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'positive regulation of mesenchymal cell proliferation', 'positive regulation of metanephric cap mesenchymal cell proliferation', 'positive regulation of miRNA transcription', 'positive regulation of response to DNA damage stimulus', 'positive regulation of telomerase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein-DNA complex disassembly', 'regulation of cell cycle process', 'regulation of gene expression', 'regulation of somatic stem cell population maintenance', 'regulation of telomere maintenance', 'regulation of transcription by RNA polymerase II', 'response to gamma radiation', 'response to growth factor', 'response to xenobiotic stimulus']['branching involved in ureteric bud morphogenesis', 'cellular iron ion homeostasis', 'cellular response to DNA damage stimulus', 'cellular response to hypoxia', 'cellular response to UV', 'cellular response to xenobiotic stimulus', 'chromatin remodeling', 'chromosome organization', 'energy reserve metabolic process', 'ERK1 and ERK2 cascade', 'fibroblast apoptotic process', 'G1/S transition of mitotic cell cycle', 'MAPK cascade', 'negative regulation of apoptotic process', 'negative regulation of cell division', 'negative regulation of fibroblast proliferation', 'negative regulation of monocyte differentiation', 'negative regulation of stress-activated MAPK cascade', 'negative regulation of transcription by RNA polymerase II', 'oxygen transport', 'positive regulation of cell population proliferation', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of DNA biosynthetic process', 'positive regulation of DNA methylation', 'positive regulation of epithelial cell proliferation', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'positive regulation of mesenchymal cell proliferation', 'positive regulation of metanephric cap mesenchymal cell proliferation', 'positive regulation of miRNA transcription', 'positive regulation of response to DNA damage stimulus', 'positive regulation of telomerase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein-DNA complex disassembly', 'regulation of cell cycle process', 'regulation of gene expression', 'regulation of somatic stem cell population maintenance', 'regulation of telomere maintenance', 'regulation of transcription by RNA polymerase II', 'response to gamma radiation', 'response to growth factor', 'response to xenobiotic stimulus']
Chymotrypsinogen B
154
Chymotrypsinogen B
219
2.0
69
0.71
P07338P07338['digestion', 'positive regulation of apoptotic process', 'protein catabolic process', 'proteolysis', 'response to cytokine', 'response to food', 'response to nutrient', 'response to peptide hormone', 'response to toxic substance']['digestion', 'positive regulation of apoptotic process', 'protein catabolic process', 'proteolysis', 'response to cytokine', 'response to food', 'response to nutrient', 'response to peptide hormone', 'response to toxic substance']
Lysine-specific demethylase 4B
165
Lysine-specific demethylase 4B
165
2.0
68
0.72
O94953O94953['brain development', 'chromatin remodeling', 'histone H3-K36 demethylation', 'histone H3-K9 demethylation']['brain development', 'chromatin remodeling', 'histone H3-K36 demethylation', 'histone H3-K9 demethylation']
Protein Aster-A
419
Protein Aster-A
419
2.0
45
1.09
Q8VEF1Q8VEF1['autophagy', 'cellular response to cholesterol', 'intracellular sterol transport']['autophagy', 'cellular response to cholesterol', 'intracellular sterol transport']
NACHT, LRR and PYD domains-containing protein 9
612
NACHT, LRR and PYD domains-containing protein 9
296
2.0
79
0.62
Q288C4Q288C4['inflammatory response', 'innate immune response']['inflammatory response', 'innate immune response']
Protein KIBRA
771
Protein KIBRA
771
2.0
71
0.69
Q8IX03Q8IX03['cell migration', 'establishment of cell polarity', 'negative regulation of hippo signaling', 'negative regulation of organ growth', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of MAPK cascade', 'regulation of hippo signaling', 'regulation of intracellular transport', 'regulation of transcription, DNA-templated']['cell migration', 'establishment of cell polarity', 'negative regulation of hippo signaling', 'negative regulation of organ growth', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of MAPK cascade', 'regulation of hippo signaling', 'regulation of intracellular transport', 'regulation of transcription, DNA-templated']
Voltage-gated hydrogen channel 1
249
Voltage-gated hydrogen channel 1
249
2.0
53
0.93
Q96D96Q96D96['cell redox homeostasis', 'cellular response to pH', 'cellular response to zinc ion', 'positive regulation of superoxide anion generation', 'proton transmembrane transport', 'regulation of intracellular pH', 'regulation of ion transmembrane transport', 'response to pH', 'response to zinc ion']['cell redox homeostasis', 'cellular response to pH', 'cellular response to zinc ion', 'positive regulation of superoxide anion generation', 'proton transmembrane transport', 'regulation of intracellular pH', 'regulation of ion transmembrane transport', 'response to pH', 'response to zinc ion']
Transforming growth factor beta-1 proprotein
355
Transforming growth factor beta-1 proprotein
355
2.0
80
0.61
P07200P07200['adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains', 'aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'branch elongation involved in mammary gland duct branching', 'bronchiole development', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'cellular calcium ion homeostasis', 'cellular response to ionizing radiation', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'chondrocyte differentiation', 'columnar/cuboidal epithelial cell maturation', 'common-partner SMAD protein phosphorylation', 'embryonic liver development', 'enamel mineralization', 'endoderm development', 'epidermal growth factor receptor signaling pathway', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'face morphogenesis', 'gene expression', 'germ cell migration', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'Langerhans cell differentiation', 'lens fiber cell differentiation', 'lipopolysaccharide-mediated signaling pathway', 'lung alveolus development', 'lymph node development', 'mammary gland branching involved in thelarche', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'muscle cell cellular homeostasis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of epithelial cell proliferation', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of interleukin-17 production', 'negative regulation of macrophage cytokine production', 'negative regulation of myoblast differentiation', 'negative regulation of ossification', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of T cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'Notch signaling pathway', 'oligodendrocyte development', 'ossification involved in bone remodeling', 'osteoclast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'phospholipid homeostasis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of histone acetylation', 'positive regulation of histone deacetylation', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of odontogenesis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor clustering', 'positive regulation of regulatory T cell differentiation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stem cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of actin cytoskeleton reorganization', 'regulation of binding', 'regulation of branching involved in mammary gland duct morphogenesis', 'regulation of cartilage development', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of interleukin-23 production', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of sodium ion transport', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulatory T cell differentiation', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'stem cell proliferation', 'surfactant homeostasis', 'T cell homeostasis', 'T cell proliferation', 'tolerance induction to self antigen', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'ureteric bud development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains', 'aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'branch elongation involved in mammary gland duct branching', 'bronchiole development', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'cellular calcium ion homeostasis', 'cellular response to ionizing radiation', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'chondrocyte differentiation', 'columnar/cuboidal epithelial cell maturation', 'common-partner SMAD protein phosphorylation', 'embryonic liver development', 'enamel mineralization', 'endoderm development', 'epidermal growth factor receptor signaling pathway', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'face morphogenesis', 'gene expression', 'germ cell migration', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'Langerhans cell differentiation', 'lens fiber cell differentiation', 'lipopolysaccharide-mediated signaling pathway', 'lung alveolus development', 'lymph node development', 'mammary gland branching involved in thelarche', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'muscle cell cellular homeostasis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of epithelial cell proliferation', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of interleukin-17 production', 'negative regulation of macrophage cytokine production', 'negative regulation of myoblast differentiation', 'negative regulation of ossification', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of T cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'Notch signaling pathway', 'oligodendrocyte development', 'ossification involved in bone remodeling', 'osteoclast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'phospholipid homeostasis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of histone acetylation', 'positive regulation of histone deacetylation', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of odontogenesis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor clustering', 'positive regulation of regulatory T cell differentiation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stem cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of actin cytoskeleton reorganization', 'regulation of binding', 'regulation of branching involved in mammary gland duct morphogenesis', 'regulation of cartilage development', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of interleukin-23 production', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of sodium ion transport', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulatory T cell differentiation', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'stem cell proliferation', 'surfactant homeostasis', 'T cell homeostasis', 'T cell proliferation', 'tolerance induction to self antigen', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'ureteric bud development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']
Mannan-binding lectin serine protease 1
436
Mannan-binding lectin serine protease 1
572
2.0
81
0.61
P48740P48740['cell surface pattern recognition receptor signaling pathway', 'complement activation, lectin pathway', 'negative regulation of complement activation', 'positive regulation of opsonization', 'proteolysis']['cell surface pattern recognition receptor signaling pathway', 'complement activation, lectin pathway', 'negative regulation of complement activation', 'positive regulation of opsonization', 'proteolysis']
Cryptochrome-2
430
F-box/LRR-repeat protein 3
340
2.0
89
0.55
Q9R194Q9UKT7['circadian regulation of gene expression', 'circadian rhythm', 'entrainment of circadian clock by photoperiod', 'glucose homeostasis', 'lipid storage', 'negative regulation of circadian rhythm', 'negative regulation of glucocorticoid receptor signaling pathway', 'negative regulation of glucocorticoid secretion', 'negative regulation of phosphoprotein phosphatase activity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'protein import into nucleus', 'regulation of circadian rhythm', 'regulation of sodium-dependent phosphate transport', 'response to activity', 'response to insulin', 'response to light stimulus']['entrainment of circadian clock by photoperiod', 'G2/M transition of mitotic cell cycle', 'protein destabilization', 'protein ubiquitination', 'regulation of cell cycle', 'regulation of circadian rhythm', 'rhythmic process', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process']
Norrin
93
Norrin
95
2.0
80
0.61
Q00604Q00604['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']
Induced myeloid leukemia cell differentiation protein Mcl-1
286
Induced myeloid leukemia cell differentiation protein Mcl-1
286
2.0
62
0.79
Q07820Q07820['cell fate determination', 'cellular homeostasis', 'extrinsic apoptotic signaling pathway in absence of ligand', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of anoikis', 'negative regulation of apoptotic process', 'negative regulation of autophagy', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of intrinsic apoptotic signaling pathway', 'positive regulation of apoptotic process', 'positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'regulation of apoptotic process', 'regulation of response to DNA damage stimulus', 'response to cytokine']['cell fate determination', 'cellular homeostasis', 'extrinsic apoptotic signaling pathway in absence of ligand', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of anoikis', 'negative regulation of apoptotic process', 'negative regulation of autophagy', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of intrinsic apoptotic signaling pathway', 'positive regulation of apoptotic process', 'positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'regulation of apoptotic process', 'regulation of response to DNA damage stimulus', 'response to cytokine']
Thymocyte nuclear protein 1
118
Thymocyte nuclear protein 1
118
2.0
48
1.02
Q9P016Q9P016[][]
MAb 106 heavy chain
148
MAb 110 light chain
239
2.0
nan
nan
A0A0F7R1P3A0A0F7R5U8[][]
Interleukin-6 receptor subunit beta
419
Interleukin-6 receptor subunit beta
419
2.0
66
0.74
P40189P40189['ciliary neurotrophic factor-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'glycogen metabolic process', 'interleukin-27-mediated signaling pathway', 'interleukin-6-mediated signaling pathway', 'intestinal epithelial cell development', 'leukemia inhibitory factor signaling pathway', 'negative regulation of apoptotic process', 'negative regulation of interleukin-6-mediated signaling pathway', 'negative regulation of neuron apoptotic process', 'oncostatin-M-mediated signaling pathway', 'positive regulation of acute inflammatory response', 'positive regulation of adaptive immune response', 'positive regulation of astrocyte differentiation', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cell population proliferation', 'positive regulation of Notch signaling pathway', 'positive regulation of osteoblast differentiation', 'positive regulation of platelet aggregation', 'positive regulation of T cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of vascular endothelial growth factor production', 'response to cytokine']['ciliary neurotrophic factor-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'glycogen metabolic process', 'interleukin-27-mediated signaling pathway', 'interleukin-6-mediated signaling pathway', 'intestinal epithelial cell development', 'leukemia inhibitory factor signaling pathway', 'negative regulation of apoptotic process', 'negative regulation of interleukin-6-mediated signaling pathway', 'negative regulation of neuron apoptotic process', 'oncostatin-M-mediated signaling pathway', 'positive regulation of acute inflammatory response', 'positive regulation of adaptive immune response', 'positive regulation of astrocyte differentiation', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cell population proliferation', 'positive regulation of Notch signaling pathway', 'positive regulation of osteoblast differentiation', 'positive regulation of platelet aggregation', 'positive regulation of T cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of vascular endothelial growth factor production', 'response to cytokine']
Complement C4-A
1394
Complement C4-B
1566
2.0
56
0.88
P0C0L4P0C0L5['complement activation', 'complement activation, classical pathway', 'inflammatory response', 'innate immune response', 'positive regulation of apoptotic cell clearance', 'positive regulation of immune response', 'positive regulation of opsonization']['complement activation', 'complement activation, classical pathway', 'detection of molecule of bacterial origin', 'inflammatory response', 'innate immune response', 'opsonization', 'positive regulation of apoptotic cell clearance', 'positive regulation of immune response', 'positive regulation of opsonization']
Kinesin-like protein KIF20A
607
Kinesin-like protein KIF20A
607
2.0
46
1.07
O95235O95235['microtubule bundle formation', 'microtubule-based movement', 'midbody abscission', 'mitotic cytokinesis', 'protein transport', 'regulation of cytokinesis']['microtubule bundle formation', 'microtubule-based movement', 'midbody abscission', 'mitotic cytokinesis', 'protein transport', 'regulation of cytokinesis']
Complement C4-A
876
Complement C4-A
1590
2.0
79
0.62
P0C0L4P0C0L4['complement activation', 'complement activation, classical pathway', 'inflammatory response', 'innate immune response', 'positive regulation of apoptotic cell clearance', 'positive regulation of immune response', 'positive regulation of opsonization']['complement activation', 'complement activation, classical pathway', 'inflammatory response', 'innate immune response', 'positive regulation of apoptotic cell clearance', 'positive regulation of immune response', 'positive regulation of opsonization']
Bone morphogenetic protein 10
388
Bone morphogenetic protein 10
388
2.0
89
0.55
O95393O95393['activin receptor signaling pathway', 'adult heart development', 'atrial cardiac muscle tissue morphogenesis', 'BMP signaling pathway', 'cardiac muscle cell proliferation', 'cell adhesion', 'heart trabecula formation', 'kidney development', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of endothelial cell migration', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cartilage development', 'positive regulation of cell proliferation involved in heart morphogenesis', 'positive regulation of gene expression', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of sarcomere organization', 'positive regulation of transcription, DNA-templated', 'regulation of cardiac muscle contraction', 'regulation of cardiac muscle hypertrophy in response to stress', 'sarcomere organization', 'SMAD protein signal transduction', 'ventricular cardiac muscle cell development', 'ventricular cardiac muscle tissue morphogenesis']['activin receptor signaling pathway', 'adult heart development', 'atrial cardiac muscle tissue morphogenesis', 'BMP signaling pathway', 'cardiac muscle cell proliferation', 'cell adhesion', 'heart trabecula formation', 'kidney development', 'negative regulation of cardiac muscle hypertrophy', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of endothelial cell migration', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cartilage development', 'positive regulation of cell proliferation involved in heart morphogenesis', 'positive regulation of gene expression', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of sarcomere organization', 'positive regulation of transcription, DNA-templated', 'regulation of cardiac muscle contraction', 'regulation of cardiac muscle hypertrophy in response to stress', 'sarcomere organization', 'SMAD protein signal transduction', 'ventricular cardiac muscle cell development', 'ventricular cardiac muscle tissue morphogenesis']
Bone marrow stromal antigen 2
68
Bone marrow stromal antigen 2
68
2.0
50
0.99
Q8R2Q8Q8R2Q8['defense response to virus', 'innate immune response', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of intracellular transport of viral material', 'negative regulation of plasmacytoid dendritic cell cytokine production', 'negative regulation of viral genome replication', 'regulation of actin cytoskeleton organization', 'response to interferon-alpha', 'response to interferon-beta', 'response to interferon-gamma', 'response to virus']['defense response to virus', 'innate immune response', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of intracellular transport of viral material', 'negative regulation of plasmacytoid dendritic cell cytokine production', 'negative regulation of viral genome replication', 'regulation of actin cytoskeleton organization', 'response to interferon-alpha', 'response to interferon-beta', 'response to interferon-gamma', 'response to virus']
cGMP-dependent protein kinase 1
43
cGMP-dependent protein kinase 1
43
2.0
45
1.09
1
✔Q13976Q13976['actin cytoskeleton organization', 'cGMP-mediated signaling', 'dendrite development', 'forebrain development', 'negative regulation of platelet aggregation', 'negative regulation of vascular associated smooth muscle cell migration', 'negative regulation of vascular associated smooth muscle cell proliferation', 'neuron migration', 'protein phosphorylation', 'regulation of GTPase activity', 'relaxation of vascular associated smooth muscle', 'signal transduction']['actin cytoskeleton organization', 'cGMP-mediated signaling', 'dendrite development', 'forebrain development', 'negative regulation of platelet aggregation', 'negative regulation of vascular associated smooth muscle cell migration', 'negative regulation of vascular associated smooth muscle cell proliferation', 'neuron migration', 'protein phosphorylation', 'regulation of GTPase activity', 'relaxation of vascular associated smooth muscle', 'signal transduction']
Nuclear receptor ROR-gamma
393
Nuclear receptor ROR-gamma
393
2.0
66
0.75
P51449P51449['adipose tissue development', 'cellular response to sterol', 'circadian regulation of gene expression', 'lymph node development', 'negative regulation of thymocyte apoptotic process', 'negative regulation of transcription by RNA polymerase II', "Peyer's patch development", 'positive regulation of circadian rhythm', 'positive regulation of transcription, DNA-templated', 'regulation of fat cell differentiation', 'regulation of glucose metabolic process', 'regulation of steroid metabolic process', 'regulation of transcription by RNA polymerase II', 'T-helper 17 cell differentiation', 'T-helper cell differentiation', 'xenobiotic metabolic process']['adipose tissue development', 'cellular response to sterol', 'circadian regulation of gene expression', 'lymph node development', 'negative regulation of thymocyte apoptotic process', 'negative regulation of transcription by RNA polymerase II', "Peyer's patch development", 'positive regulation of circadian rhythm', 'positive regulation of transcription, DNA-templated', 'regulation of fat cell differentiation', 'regulation of glucose metabolic process', 'regulation of steroid metabolic process', 'regulation of transcription by RNA polymerase II', 'T-helper 17 cell differentiation', 'T-helper cell differentiation', 'xenobiotic metabolic process']
Bone morphogenetic protein 6
477
Bone morphogenetic protein 6
477
2.0
84
0.59
P22004P22004['BMP signaling pathway', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'cellular response to iron ion', 'cellular response to mechanical stimulus', 'endochondral ossification', 'eye development', 'immune response', 'inflammatory response', 'kidney development', 'male genitalia development', 'multicellular organismal iron ion homeostasis', 'negative regulation of adherens junction organization', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of transcription by RNA polymerase II', 'neuron differentiation', 'osteoblast differentiation', 'positive regulation of aldosterone biosynthetic process', 'positive regulation of aldosterone secretion', 'positive regulation of bone mineralization', 'positive regulation of cell population proliferation', 'positive regulation of chondrocyte differentiation', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of gene expression', 'positive regulation of lipopolysaccharide-mediated signaling pathway', 'positive regulation of neuron differentiation', 'positive regulation of osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vascular permeability', 'response to activity', 'response to glucocorticoid', 'response to magnesium ion', 'response to retinoic acid', 'skeletal system development', 'SMAD protein signal transduction', 'type B pancreatic cell development']['BMP signaling pathway', 'cartilage development', 'cellular iron ion homeostasis', 'cellular response to BMP stimulus', 'cellular response to iron ion', 'cellular response to mechanical stimulus', 'endochondral ossification', 'eye development', 'immune response', 'inflammatory response', 'kidney development', 'male genitalia development', 'multicellular organismal iron ion homeostasis', 'negative regulation of adherens junction organization', 'negative regulation of cell-cell adhesion mediated by cadherin', 'negative regulation of transcription by RNA polymerase II', 'neuron differentiation', 'osteoblast differentiation', 'positive regulation of aldosterone biosynthetic process', 'positive regulation of aldosterone secretion', 'positive regulation of bone mineralization', 'positive regulation of cell population proliferation', 'positive regulation of chondrocyte differentiation', 'positive regulation of endothelial cell differentiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of gene expression', 'positive regulation of lipopolysaccharide-mediated signaling pathway', 'positive regulation of neuron differentiation', 'positive regulation of osteoblast differentiation', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vascular permeability', 'response to activity', 'response to glucocorticoid', 'response to magnesium ion', 'response to retinoic acid', 'skeletal system development', 'SMAD protein signal transduction', 'type B pancreatic cell development']
Synaptonemal complex protein 1
703
Synaptonemal complex protein 1
703
2.0
61
0.81
Q15431Q15431['cell division', 'chiasma assembly', 'homologous chromosome pairing at meiosis', 'lateral element assembly', 'meiotic DNA repair synthesis', 'protein homotetramerization', 'reciprocal meiotic recombination', 'regulation of protein localization', 'sperm DNA condensation', 'spermatogenesis', 'synaptonemal complex assembly']['cell division', 'chiasma assembly', 'homologous chromosome pairing at meiosis', 'lateral element assembly', 'meiotic DNA repair synthesis', 'protein homotetramerization', 'reciprocal meiotic recombination', 'regulation of protein localization', 'sperm DNA condensation', 'spermatogenesis', 'synaptonemal complex assembly']
Cathepsin B
105
Cathepsin B
150
2.0
71
0.69
P07688P07688['cellular response to thyroid hormone stimulus', 'collagen catabolic process', 'decidualization', 'epithelial cell differentiation', 'negative regulation of peptidase activity', 'proteolysis involved in protein catabolic process', 'thyroid hormone generation', 'viral entry into host cell']['cellular response to thyroid hormone stimulus', 'collagen catabolic process', 'decidualization', 'epithelial cell differentiation', 'negative regulation of peptidase activity', 'proteolysis involved in protein catabolic process', 'thyroid hormone generation', 'viral entry into host cell']
Transforming growth factor beta-1 proprotein
223
Transforming growth factor beta-1 proprotein
225
2.0
67
0.74
P07200P07200['adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains', 'aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'branch elongation involved in mammary gland duct branching', 'bronchiole development', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'cellular calcium ion homeostasis', 'cellular response to ionizing radiation', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'chondrocyte differentiation', 'columnar/cuboidal epithelial cell maturation', 'common-partner SMAD protein phosphorylation', 'embryonic liver development', 'enamel mineralization', 'endoderm development', 'epidermal growth factor receptor signaling pathway', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'face morphogenesis', 'gene expression', 'germ cell migration', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'Langerhans cell differentiation', 'lens fiber cell differentiation', 'lipopolysaccharide-mediated signaling pathway', 'lung alveolus development', 'lymph node development', 'mammary gland branching involved in thelarche', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'muscle cell cellular homeostasis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of epithelial cell proliferation', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of interleukin-17 production', 'negative regulation of macrophage cytokine production', 'negative regulation of myoblast differentiation', 'negative regulation of ossification', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of T cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'Notch signaling pathway', 'oligodendrocyte development', 'ossification involved in bone remodeling', 'osteoclast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'phospholipid homeostasis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of histone acetylation', 'positive regulation of histone deacetylation', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of odontogenesis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor clustering', 'positive regulation of regulatory T cell differentiation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stem cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of actin cytoskeleton reorganization', 'regulation of binding', 'regulation of branching involved in mammary gland duct morphogenesis', 'regulation of cartilage development', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of interleukin-23 production', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of sodium ion transport', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulatory T cell differentiation', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'stem cell proliferation', 'surfactant homeostasis', 'T cell homeostasis', 'T cell proliferation', 'tolerance induction to self antigen', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'ureteric bud development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains', 'aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'branch elongation involved in mammary gland duct branching', 'bronchiole development', 'cell migration', 'cell morphogenesis', 'cell-cell junction organization', 'cellular calcium ion homeostasis', 'cellular response to ionizing radiation', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'chondrocyte differentiation', 'columnar/cuboidal epithelial cell maturation', 'common-partner SMAD protein phosphorylation', 'embryonic liver development', 'enamel mineralization', 'endoderm development', 'epidermal growth factor receptor signaling pathway', 'epithelial cell proliferation', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'face morphogenesis', 'gene expression', 'germ cell migration', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'Langerhans cell differentiation', 'lens fiber cell differentiation', 'lipopolysaccharide-mediated signaling pathway', 'lung alveolus development', 'lymph node development', 'mammary gland branching involved in thelarche', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'muscle cell cellular homeostasis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of epithelial cell proliferation', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of interleukin-17 production', 'negative regulation of macrophage cytokine production', 'negative regulation of myoblast differentiation', 'negative regulation of ossification', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of T cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'Notch signaling pathway', 'oligodendrocyte development', 'ossification involved in bone remodeling', 'osteoclast differentiation', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'phospholipid homeostasis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of histone acetylation', 'positive regulation of histone deacetylation', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of odontogenesis', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor clustering', 'positive regulation of regulatory T cell differentiation', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stem cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of actin cytoskeleton reorganization', 'regulation of binding', 'regulation of branching involved in mammary gland duct morphogenesis', 'regulation of cartilage development', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of interleukin-23 production', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of sodium ion transport', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulatory T cell differentiation', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'stem cell proliferation', 'surfactant homeostasis', 'T cell homeostasis', 'T cell proliferation', 'tolerance induction to self antigen', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'ureteric bud development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']
Complement factor I
327
Complement factor I
453
2.0
72
0.68
P05156P05156['complement activation, classical pathway', 'innate immune response', 'proteolysis', 'regulation of complement activation, alternative pathway']['complement activation, classical pathway', 'innate immune response', 'proteolysis', 'regulation of complement activation, alternative pathway']
DNA-(apurinic or apyrimidinic site) endonuclease
138
DNA-(apurinic or apyrimidinic site) endonuclease
138
2.0
58
0.85
P27695P27695['aging', 'base-excision repair', 'base-excision repair, gap-filling', 'cell redox homeostasis', 'cellular response to cAMP', 'cellular response to hydrogen peroxide', 'cellular response to peptide hormone stimulus', 'DNA catabolic process, endonucleolytic', 'DNA demethylation', 'DNA recombination', 'DNA repair', 'negative regulation of smooth muscle cell migration', 'positive regulation of G1/S transition of mitotic cell cycle', 'positive regulation of transcription by RNA polymerase II', 'regulation of apoptotic process', 'regulation of mRNA stability', 'response to xenobiotic stimulus', 'telomere maintenance', 'telomere maintenance via base-excision repair']['aging', 'base-excision repair', 'base-excision repair, gap-filling', 'cell redox homeostasis', 'cellular response to cAMP', 'cellular response to hydrogen peroxide', 'cellular response to peptide hormone stimulus', 'DNA catabolic process, endonucleolytic', 'DNA demethylation', 'DNA recombination', 'DNA repair', 'negative regulation of smooth muscle cell migration', 'positive regulation of G1/S transition of mitotic cell cycle', 'positive regulation of transcription by RNA polymerase II', 'regulation of apoptotic process', 'regulation of mRNA stability', 'response to xenobiotic stimulus', 'telomere maintenance', 'telomere maintenance via base-excision repair']
Protein AF-9
119
Protein AF-9
119
2.0
60
0.82
P42568P42568['anterior/posterior pattern specification', 'chromatin remodeling', 'gene expression', 'hematopoietic stem cell differentiation', 'histone acetylation', 'negative regulation of canonical Wnt signaling pathway', 'positive regulation of transcription, DNA-templated', 'positive regulation of Wnt signaling pathway, planar cell polarity pathway', 'regulation of chromatin organization', 'regulation of stem cell division', 'regulation of transcription by RNA polymerase II', 'segment specification']['anterior/posterior pattern specification', 'chromatin remodeling', 'gene expression', 'hematopoietic stem cell differentiation', 'histone acetylation', 'negative regulation of canonical Wnt signaling pathway', 'positive regulation of transcription, DNA-templated', 'positive regulation of Wnt signaling pathway, planar cell polarity pathway', 'regulation of chromatin organization', 'regulation of stem cell division', 'regulation of transcription by RNA polymerase II', 'segment specification']
Vesicle-associated membrane protein-associated protein B/C
53
Vesicle-associated membrane protein-associated protein B/C
53
2.0
79
0.62
O95292O95292['cellular calcium ion homeostasis', 'COPII-coated vesicle budding', 'endoplasmic reticulum membrane organization', 'endoplasmic reticulum organization', 'endoplasmic reticulum to Golgi vesicle-mediated transport', 'endoplasmic reticulum unfolded protein response', 'endoplasmic reticulum-plasma membrane tethering', 'IRE1-mediated unfolded protein response', 'modulation by host of viral RNA genome replication', 'negative regulation by host of viral genome replication', 'negative regulation by virus of viral protein levels in host cell', 'positive regulation by host of viral genome replication', 'positive regulation of viral genome replication', 'suppression of viral release by host', 'viral release from host cell']['cellular calcium ion homeostasis', 'COPII-coated vesicle budding', 'endoplasmic reticulum membrane organization', 'endoplasmic reticulum organization', 'endoplasmic reticulum to Golgi vesicle-mediated transport', 'endoplasmic reticulum unfolded protein response', 'endoplasmic reticulum-plasma membrane tethering', 'IRE1-mediated unfolded protein response', 'modulation by host of viral RNA genome replication', 'negative regulation by host of viral genome replication', 'negative regulation by virus of viral protein levels in host cell', 'positive regulation by host of viral genome replication', 'positive regulation of viral genome replication', 'suppression of viral release by host', 'viral release from host cell']
Laminin subunit beta-1
1785
Laminin subunit gamma-1
1598
2.0
45
1.09
P02469P02468['animal organ morphogenesis', 'basement membrane assembly', 'cell migration', 'embryo implantation', 'learning or memory', 'negative regulation of cell adhesion', 'neuron projection development', 'neuronal-glial interaction involved in cerebral cortex radial glia guided migration', 'odontogenesis', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of integrin-mediated signaling pathway', 'positive regulation of muscle cell differentiation', 'regulation of basement membrane organization', 'substrate adhesion-dependent cell spreading', 'tissue development']['animal organ morphogenesis', 'cell adhesion', 'cell migration', 'chromatin organization', 'extracellular matrix disassembly', 'gene expression', 'hair cell differentiation', 'hair follicle cell proliferation', 'hair follicle morphogenesis', 'hemidesmosome assembly', 'neuron projection development', 'positive regulation of cell adhesion', 'positive regulation of integrin-mediated signaling pathway', 'positive regulation of muscle cell differentiation', 'protein-containing complex assembly', 'regulation of basement membrane organization', 'substrate adhesion-dependent cell spreading', 'tissue development', 'tissue morphogenesis']
SUMO-conjugating enzyme UBC9
138
Ran GTPase-activating protein 1
575
2.0
78
0.63
P63279P46061['cell division', 'chromosome segregation', 'mitotic nuclear membrane reassembly', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'nuclear export', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of SUMO transferase activity', 'protein modification process', 'protein sumoylation', 'ubiquitin-dependent protein catabolic process']['activation of GTPase activity', 'cellular response to peptide hormone stimulus', 'cellular response to vasopressin', 'negative regulation of protein export from nucleus', 'nuclear export', 'nucleocytoplasmic transport', 'protein sumoylation', 'response to axon injury', 'signal transduction']
Ig gamma-2A chain C region, A allele
110
Ig gamma-2A chain C region, A allele
110
2.0
30
1.64
P01863P01863['B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'response to bacterium']['B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'response to bacterium']
Regulator of G-protein signaling 3
315
Regulator of G-protein signaling 3
314
2.0
74
0.66
P49796P49796['G protein-coupled receptor signaling pathway', 'negative regulation of signal transduction', 'regulation of G protein-coupled receptor signaling pathway', 'signal transduction']['G protein-coupled receptor signaling pathway', 'negative regulation of signal transduction', 'regulation of G protein-coupled receptor signaling pathway', 'signal transduction']
Macrophage colony-stimulating factor 1
63
Macrophage colony-stimulating factor 1
63
2.0
76
0.65
P07141P07141['branching involved in mammary gland duct morphogenesis', 'cell population proliferation', 'developmental process involved in reproduction', 'homeostasis of number of cells within a tissue', 'inflammatory response', 'innate immune response', 'macrophage colony-stimulating factor signaling pathway', 'macrophage differentiation', 'macrophage homeostasis', 'mammary duct terminal end bud growth', 'mammary gland fat development', 'microglial cell proliferation', 'monocyte differentiation', 'monocyte homeostasis', 'myeloid leukocyte migration', 'negative regulation of neuron death', 'neutrophil homeostasis', 'odontogenesis', 'ossification', 'osteoclast differentiation', 'osteoclast proliferation', 'positive regulation of cell population proliferation', 'positive regulation of cell-matrix adhesion', 'positive regulation of gene expression', 'positive regulation of leukocyte migration', 'positive regulation of macrophage chemotaxis', 'positive regulation of macrophage colony-stimulating factor signaling pathway', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of macrophage differentiation', 'positive regulation of macrophage migration', 'positive regulation of microglial cell migration', 'positive regulation of monocyte differentiation', 'positive regulation of mononuclear cell proliferation', 'positive regulation of multicellular organism growth', 'positive regulation of odontogenesis of dentin-containing tooth', 'positive regulation of osteoclast differentiation', 'positive regulation of protein kinase activity', 'positive regulation of protein metabolic process', 'positive regulation of Ras protein signal transduction', 'Ras protein signal transduction', 'regulation of ossification', 'response to ischemia', 'transmembrane receptor protein tyrosine kinase signaling pathway']['branching involved in mammary gland duct morphogenesis', 'cell population proliferation', 'developmental process involved in reproduction', 'homeostasis of number of cells within a tissue', 'inflammatory response', 'innate immune response', 'macrophage colony-stimulating factor signaling pathway', 'macrophage differentiation', 'macrophage homeostasis', 'mammary duct terminal end bud growth', 'mammary gland fat development', 'microglial cell proliferation', 'monocyte differentiation', 'monocyte homeostasis', 'myeloid leukocyte migration', 'negative regulation of neuron death', 'neutrophil homeostasis', 'odontogenesis', 'ossification', 'osteoclast differentiation', 'osteoclast proliferation', 'positive regulation of cell population proliferation', 'positive regulation of cell-matrix adhesion', 'positive regulation of gene expression', 'positive regulation of leukocyte migration', 'positive regulation of macrophage chemotaxis', 'positive regulation of macrophage colony-stimulating factor signaling pathway', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of macrophage differentiation', 'positive regulation of macrophage migration', 'positive regulation of microglial cell migration', 'positive regulation of monocyte differentiation', 'positive regulation of mononuclear cell proliferation', 'positive regulation of multicellular organism growth', 'positive regulation of odontogenesis of dentin-containing tooth', 'positive regulation of osteoclast differentiation', 'positive regulation of protein kinase activity', 'positive regulation of protein metabolic process', 'positive regulation of Ras protein signal transduction', 'Ras protein signal transduction', 'regulation of ossification', 'response to ischemia', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Tyrosyl-DNA phosphodiesterase 2
137
Tyrosyl-DNA phosphodiesterase 2
137
2.0
63
0.79
Q9JJX7Q9JJX7['double-strand break repair', 'neuron development']['double-strand break repair', 'neuron development']
Immunoglobulin kappa constant
107
Ig heavy chain Mem5
135
2.0
nan
nan
P01837P84751['adaptive immune response', 'B cell differentiation', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response']
Macrophage colony-stimulating factor 1
63
Macrophage colony-stimulating factor 1
63
2.0
52
0.95
P09603P09603['branching involved in mammary gland duct morphogenesis', 'developmental process involved in reproduction', 'homeostasis of number of cells within a tissue', 'inflammatory response', 'innate immune response', 'macrophage colony-stimulating factor signaling pathway', 'macrophage differentiation', 'macrophage homeostasis', 'mammary duct terminal end bud growth', 'mammary gland fat development', 'microglial cell proliferation', 'monocyte activation', 'monocyte differentiation', 'monocyte homeostasis', 'myeloid leukocyte migration', 'negative regulation of neuron death', 'neutrophil homeostasis', 'odontogenesis', 'ossification', 'osteoclast differentiation', 'osteoclast proliferation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell-matrix adhesion', 'positive regulation of gene expression', 'positive regulation of macrophage chemotaxis', 'positive regulation of macrophage colony-stimulating factor signaling pathway', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of macrophage differentiation', 'positive regulation of macrophage migration', 'positive regulation of microglial cell migration', 'positive regulation of monocyte differentiation', 'positive regulation of mononuclear cell proliferation', 'positive regulation of multicellular organism growth', 'positive regulation of odontogenesis of dentin-containing tooth', 'positive regulation of osteoclast differentiation', 'positive regulation of protein kinase activity', 'positive regulation of protein metabolic process', 'positive regulation of Ras protein signal transduction', 'Ras protein signal transduction', 'regulation of macrophage derived foam cell differentiation', 'regulation of ossification', 'response to ischemia', 'transmembrane receptor protein tyrosine kinase signaling pathway']['branching involved in mammary gland duct morphogenesis', 'developmental process involved in reproduction', 'homeostasis of number of cells within a tissue', 'inflammatory response', 'innate immune response', 'macrophage colony-stimulating factor signaling pathway', 'macrophage differentiation', 'macrophage homeostasis', 'mammary duct terminal end bud growth', 'mammary gland fat development', 'microglial cell proliferation', 'monocyte activation', 'monocyte differentiation', 'monocyte homeostasis', 'myeloid leukocyte migration', 'negative regulation of neuron death', 'neutrophil homeostasis', 'odontogenesis', 'ossification', 'osteoclast differentiation', 'osteoclast proliferation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cell-matrix adhesion', 'positive regulation of gene expression', 'positive regulation of macrophage chemotaxis', 'positive regulation of macrophage colony-stimulating factor signaling pathway', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of macrophage differentiation', 'positive regulation of macrophage migration', 'positive regulation of microglial cell migration', 'positive regulation of monocyte differentiation', 'positive regulation of mononuclear cell proliferation', 'positive regulation of multicellular organism growth', 'positive regulation of odontogenesis of dentin-containing tooth', 'positive regulation of osteoclast differentiation', 'positive regulation of protein kinase activity', 'positive regulation of protein metabolic process', 'positive regulation of Ras protein signal transduction', 'Ras protein signal transduction', 'regulation of macrophage derived foam cell differentiation', 'regulation of ossification', 'response to ischemia', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Ras-related protein Rab-5C
64
Ras-related protein Rab-5C
64
2.0
57
0.86
P51148P51148['endocytosis', 'intracellular protein transport', 'plasma membrane to endosome transport', 'regulation of endocytosis']['endocytosis', 'intracellular protein transport', 'plasma membrane to endosome transport', 'regulation of endocytosis']
Gamma-crystallin S
25
Gamma-crystallin S
25
2.0
67
0.73
P22914P22914['lens development in camera-type eye', 'morphogenesis of an epithelium', 'visual perception']['lens development in camera-type eye', 'morphogenesis of an epithelium', 'visual perception']
Centrosomal protein of 135 kDa
110
Centrosomal protein of 135 kDa
110
2.0
48
1.02
Q66GS9Q66GS9['centriole replication', 'centriole-centriole cohesion', 'positive regulation of establishment of protein localization', 'positive regulation of non-motile cilium assembly']['centriole replication', 'centriole-centriole cohesion', 'positive regulation of establishment of protein localization', 'positive regulation of non-motile cilium assembly']
Neuropilin-2
434
Neuropilin-2
434
2.0
50
0.99
O60462O60462['angiogenesis', 'axon extension involved in axon guidance', 'axon guidance', 'cell adhesion', 'cellular response to leukemia inhibitory factor', 'dorsal root ganglion morphogenesis', 'facial nerve structural organization', 'facioacoustic ganglion development', 'gonadotrophin-releasing hormone neuronal migration to the hypothalamus', 'negative chemotaxis', 'nerve development', 'neural crest cell migration involved in autonomic nervous system development', 'outflow tract septum morphogenesis', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'regulation of postsynapse organization', 'semaphorin-plexin signaling pathway involved in neuron projection guidance', 'sensory neuron axon guidance', 'sympathetic ganglion development', 'sympathetic neuron projection extension', 'sympathetic neuron projection guidance', 'trigeminal ganglion development', 'ventral trunk neural crest cell migration', 'vestibulocochlear nerve structural organization']['angiogenesis', 'axon extension involved in axon guidance', 'axon guidance', 'cell adhesion', 'cellular response to leukemia inhibitory factor', 'dorsal root ganglion morphogenesis', 'facial nerve structural organization', 'facioacoustic ganglion development', 'gonadotrophin-releasing hormone neuronal migration to the hypothalamus', 'negative chemotaxis', 'nerve development', 'neural crest cell migration involved in autonomic nervous system development', 'outflow tract septum morphogenesis', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'regulation of postsynapse organization', 'semaphorin-plexin signaling pathway involved in neuron projection guidance', 'sensory neuron axon guidance', 'sympathetic ganglion development', 'sympathetic neuron projection extension', 'sympathetic neuron projection guidance', 'trigeminal ganglion development', 'ventral trunk neural crest cell migration', 'vestibulocochlear nerve structural organization']
Platelet-derived growth factor subunit A
123
Platelet-derived growth factor subunit A
132
2.0
72
0.69
P04085P04085['actin cytoskeleton organization', 'angiogenesis', 'animal organ morphogenesis', 'cell activation', 'cell projection assembly', 'cell-cell signaling', 'cellular response to transforming growth factor beta stimulus', 'embryonic lung development', 'hair follicle development', 'inner ear development', 'lung alveolus development', 'male gonad development', 'negative chemotaxis', 'negative regulation of phosphatidylinositol biosynthetic process', 'negative regulation of platelet activation', 'platelet-derived growth factor receptor signaling pathway', 'platelet-derived growth factor receptor-alpha signaling pathway', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mesenchymal cell proliferation', 'positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'regulation of actin cytoskeleton organization', 'regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of smooth muscle cell migration', 'response to estradiol', 'response to hypoxia', 'response to inorganic substance', 'response to retinoic acid', 'response to wounding', 'response to xenobiotic stimulus', 'skin development', 'wound healing']['actin cytoskeleton organization', 'angiogenesis', 'animal organ morphogenesis', 'cell activation', 'cell projection assembly', 'cell-cell signaling', 'cellular response to transforming growth factor beta stimulus', 'embryonic lung development', 'hair follicle development', 'inner ear development', 'lung alveolus development', 'male gonad development', 'negative chemotaxis', 'negative regulation of phosphatidylinositol biosynthetic process', 'negative regulation of platelet activation', 'platelet-derived growth factor receptor signaling pathway', 'platelet-derived growth factor receptor-alpha signaling pathway', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mesenchymal cell proliferation', 'positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'regulation of actin cytoskeleton organization', 'regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of smooth muscle cell migration', 'response to estradiol', 'response to hypoxia', 'response to inorganic substance', 'response to retinoic acid', 'response to wounding', 'response to xenobiotic stimulus', 'skin development', 'wound healing']
Protein S100-A10
62
Protein S100-A10
62
2.0
42
1.18
P60903P60903['membrane raft assembly', 'mRNA transcription by RNA polymerase II', 'positive regulation of binding', 'positive regulation of exocytosis', 'positive regulation of focal adhesion assembly', 'positive regulation of GTPase activity', 'positive regulation of plasma membrane repair', 'positive regulation of plasminogen activation', 'positive regulation of stress fiber assembly', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of transcription by RNA polymerase II', 'protein localization to plasma membrane', 'regulation of neurogenesis', 'vesicle budding from membrane']['membrane raft assembly', 'mRNA transcription by RNA polymerase II', 'positive regulation of binding', 'positive regulation of exocytosis', 'positive regulation of focal adhesion assembly', 'positive regulation of GTPase activity', 'positive regulation of plasma membrane repair', 'positive regulation of plasminogen activation', 'positive regulation of stress fiber assembly', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of transcription by RNA polymerase II', 'protein localization to plasma membrane', 'regulation of neurogenesis', 'vesicle budding from membrane']
U2 small nuclear ribonucleoprotein A'
77
U2 small nuclear ribonucleoprotein A'
77
2.0
79
0.63
P09661P09661['mRNA splicing, via spliceosome', 'RNA splicing', 'spermatogenesis', 'U2-type prespliceosome assembly']['mRNA splicing, via spliceosome', 'RNA splicing', 'spermatogenesis', 'U2-type prespliceosome assembly']
Plexin-B2
1510
Plexin-B2
1508
2.0
39
1.26
B2RXS4B2RXS4['brain development', 'excitatory synapse assembly', 'homophilic cell adhesion via plasma membrane adhesion molecules', 'negative regulation of cell adhesion', 'neural tube closure', 'neuroblast proliferation', 'positive regulation of axonogenesis', 'positive regulation of neuron projection development', 'positive regulation of translation', 'regulation of cell migration', 'regulation of cell shape', 'regulation of GTPase activity', 'regulation of neuron migration', 'regulation of protein phosphorylation', 'semaphorin-plexin signaling pathway', 'semaphorin-plexin signaling pathway involved in axon guidance']['brain development', 'excitatory synapse assembly', 'homophilic cell adhesion via plasma membrane adhesion molecules', 'negative regulation of cell adhesion', 'neural tube closure', 'neuroblast proliferation', 'positive regulation of axonogenesis', 'positive regulation of neuron projection development', 'positive regulation of translation', 'regulation of cell migration', 'regulation of cell shape', 'regulation of GTPase activity', 'regulation of neuron migration', 'regulation of protein phosphorylation', 'semaphorin-plexin signaling pathway', 'semaphorin-plexin signaling pathway involved in axon guidance']
Leukocyte immunoglobulin-like receptor subfamily A member 2
143
Leukocyte immunoglobulin-like receptor subfamily A member 2
195
2.0
85
0.58
Q8N149Q8N149['cytokine-mediated signaling pathway', 'defense response', 'innate immune response', 'innate immune response activating cell surface receptor signaling pathway', 'negative regulation of lipopolysaccharide-mediated signaling pathway', 'negative regulation of toll-like receptor 4 signaling pathway', 'neutrophil activation involved in immune response', 'positive regulation of calcium ion transport', 'positive regulation of cell activation', 'positive regulation of granulocyte colony-stimulating factor production', 'positive regulation of granulocyte macrophage colony-stimulating factor production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of tumor necrosis factor production', 'signal transduction']['cytokine-mediated signaling pathway', 'defense response', 'innate immune response', 'innate immune response activating cell surface receptor signaling pathway', 'negative regulation of lipopolysaccharide-mediated signaling pathway', 'negative regulation of toll-like receptor 4 signaling pathway', 'neutrophil activation involved in immune response', 'positive regulation of calcium ion transport', 'positive regulation of cell activation', 'positive regulation of granulocyte colony-stimulating factor production', 'positive regulation of granulocyte macrophage colony-stimulating factor production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of tumor necrosis factor production', 'signal transduction']
Glutathione reductase, mitochondrial
134
Glutathione reductase, mitochondrial
134
2.0
50
0.98
P00390P00390['cell redox homeostasis', 'cellular response to oxidative stress', 'glutathione metabolic process']['cell redox homeostasis', 'cellular response to oxidative stress', 'glutathione metabolic process']
Hairy/enhancer-of-split related with YRPW motif protein 1
130
Hairy/enhancer-of-split related with YRPW motif protein 1
130
2.0
78
0.63
Q9Y5J3Q9Y5J3['angiogenesis', 'anterior/posterior pattern specification', 'aortic valve morphogenesis', 'arterial endothelial cell differentiation', 'atrioventricular valve formation', 'cardiac conduction system development', 'cardiac epithelial to mesenchymal transition', 'cardiac septum morphogenesis', 'cardiac ventricle morphogenesis', 'circulatory system development', 'dorsal aorta morphogenesis', 'endocardial cushion morphogenesis', 'heart trabecula formation', 'labyrinthine layer blood vessel development', 'negative regulation of biomineral tissue development', 'negative regulation of neuron differentiation', 'negative regulation of Notch signaling pathway', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation', 'negative regulation of transcription regulatory region DNA binding', 'negative regulation of transcription, DNA-templated', 'Notch signaling involved in heart development', 'Notch signaling pathway', 'positive regulation of gene expression', 'positive regulation of transcription by RNA polymerase II', 'pulmonary valve morphogenesis', 'regulation of neurogenesis', 'regulation of transcription by RNA polymerase II', 'regulation of vasculogenesis', 'umbilical cord morphogenesis', 'ventricular septum morphogenesis']['angiogenesis', 'anterior/posterior pattern specification', 'aortic valve morphogenesis', 'arterial endothelial cell differentiation', 'atrioventricular valve formation', 'cardiac conduction system development', 'cardiac epithelial to mesenchymal transition', 'cardiac septum morphogenesis', 'cardiac ventricle morphogenesis', 'circulatory system development', 'dorsal aorta morphogenesis', 'endocardial cushion morphogenesis', 'heart trabecula formation', 'labyrinthine layer blood vessel development', 'negative regulation of biomineral tissue development', 'negative regulation of neuron differentiation', 'negative regulation of Notch signaling pathway', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation', 'negative regulation of transcription regulatory region DNA binding', 'negative regulation of transcription, DNA-templated', 'Notch signaling involved in heart development', 'Notch signaling pathway', 'positive regulation of gene expression', 'positive regulation of transcription by RNA polymerase II', 'pulmonary valve morphogenesis', 'regulation of neurogenesis', 'regulation of transcription by RNA polymerase II', 'regulation of vasculogenesis', 'umbilical cord morphogenesis', 'ventricular septum morphogenesis']
Integrin beta-2
33
Integrin beta-2
447
2.0
69
0.71
P05107P05107['amyloid-beta clearance', 'apoptotic process', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-cell adhesion', 'cell-cell adhesion via plasma-membrane adhesion molecules', 'cell-cell signaling', 'cell-matrix adhesion', 'cellular response to low-density lipoprotein particle stimulus', 'endodermal cell differentiation', 'heterotypic cell-cell adhesion', 'inflammatory response', 'integrin-mediated signaling pathway', 'leukocyte cell-cell adhesion', 'microglial cell activation', 'negative regulation of dopamine metabolic process', 'neutrophil chemotaxis', 'neutrophil migration', 'phagocytosis, engulfment', 'positive regulation of leukocyte adhesion to vascular endothelial cell', 'positive regulation of neuron death', 'positive regulation of neutrophil degranulation', 'positive regulation of prostaglandin-E synthase activity', 'positive regulation of protein targeting to membrane', 'positive regulation of superoxide anion generation', 'receptor clustering', 'receptor internalization', 'receptor-mediated endocytosis', 'regulation of cell shape', 'regulation of peptidyl-tyrosine phosphorylation']['amyloid-beta clearance', 'apoptotic process', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-cell adhesion', 'cell-cell adhesion via plasma-membrane adhesion molecules', 'cell-cell signaling', 'cell-matrix adhesion', 'cellular response to low-density lipoprotein particle stimulus', 'endodermal cell differentiation', 'heterotypic cell-cell adhesion', 'inflammatory response', 'integrin-mediated signaling pathway', 'leukocyte cell-cell adhesion', 'microglial cell activation', 'negative regulation of dopamine metabolic process', 'neutrophil chemotaxis', 'neutrophil migration', 'phagocytosis, engulfment', 'positive regulation of leukocyte adhesion to vascular endothelial cell', 'positive regulation of neuron death', 'positive regulation of neutrophil degranulation', 'positive regulation of prostaglandin-E synthase activity', 'positive regulation of protein targeting to membrane', 'positive regulation of superoxide anion generation', 'receptor clustering', 'receptor internalization', 'receptor-mediated endocytosis', 'regulation of cell shape', 'regulation of peptidyl-tyrosine phosphorylation']
Cytohesin-3
342
Cytohesin-3
342
2.0
77
0.64
O08967O08967['establishment of epithelial cell polarity', 'Golgi vesicle transport', 'positive regulation of cell adhesion', 'regulation of ARF protein signal transduction']['establishment of epithelial cell polarity', 'Golgi vesicle transport', 'positive regulation of cell adhesion', 'regulation of ARF protein signal transduction']
Bone marrow stromal antigen 2
96
Bone marrow stromal antigen 2
96
2.0
53
0.93
Q8R2Q8Q8R2Q8['defense response to virus', 'innate immune response', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of intracellular transport of viral material', 'negative regulation of plasmacytoid dendritic cell cytokine production', 'negative regulation of viral genome replication', 'regulation of actin cytoskeleton organization', 'response to interferon-alpha', 'response to interferon-beta', 'response to interferon-gamma', 'response to virus']['defense response to virus', 'innate immune response', 'negative regulation of cell growth', 'negative regulation of cell migration', 'negative regulation of intracellular transport of viral material', 'negative regulation of plasmacytoid dendritic cell cytokine production', 'negative regulation of viral genome replication', 'regulation of actin cytoskeleton organization', 'response to interferon-alpha', 'response to interferon-beta', 'response to interferon-gamma', 'response to virus']
Eukaryotic translation initiation factor 5A-1
129
Eukaryotic translation initiation factor 5A-1
129
2.0
44
1.12
P63241P63241['cellular response to virus', 'positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of translational elongation', 'positive regulation of translational termination', 'tumor necrosis factor-mediated signaling pathway']['cellular response to virus', 'positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of translational elongation', 'positive regulation of translational termination', 'tumor necrosis factor-mediated signaling pathway']
ADP-ribosylation factor-binding protein GGA1
77
ADP-ribosylation factor-binding protein GGA1
34
6.9
77
0.19
Q9UJY5Q9UJY5['Golgi to plasma membrane protein transport', 'Golgi to plasma membrane transport', 'intracellular protein transport', 'positive regulation of protein catabolic process', 'protein catabolic process', 'protein localization', 'protein localization to cell surface', 'protein localization to ciliary membrane', 'retrograde transport, endosome to Golgi', 'toxin transport']['Golgi to plasma membrane protein transport', 'Golgi to plasma membrane transport', 'intracellular protein transport', 'positive regulation of protein catabolic process', 'protein catabolic process', 'protein localization', 'protein localization to cell surface', 'protein localization to ciliary membrane', 'retrograde transport, endosome to Golgi', 'toxin transport']
Legumain
189
Legumain
189
6.9
100
0.14
Q99538Q99538['activation of cysteine-type endopeptidase activity', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'associative learning', 'cellular response to amyloid-beta', 'cellular response to calcium ion', 'cellular response to hepatocyte growth factor stimulus', 'dendritic spine organization', 'memory', 'negative regulation of ERBB signaling pathway', 'negative regulation of gene expression', 'negative regulation of multicellular organism growth', 'negative regulation of neuron apoptotic process', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell chemotaxis', 'positive regulation of long-term synaptic potentiation', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'proteolysis', 'proteolysis involved in protein catabolic process', 'receptor catabolic process', 'renal system process', 'response to acidic pH', 'self proteolysis', 'vacuolar protein processing', 'vitamin D metabolic process']['activation of cysteine-type endopeptidase activity', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'associative learning', 'cellular response to amyloid-beta', 'cellular response to calcium ion', 'cellular response to hepatocyte growth factor stimulus', 'dendritic spine organization', 'memory', 'negative regulation of ERBB signaling pathway', 'negative regulation of gene expression', 'negative regulation of multicellular organism growth', 'negative regulation of neuron apoptotic process', 'positive regulation of cell population proliferation', 'positive regulation of endothelial cell chemotaxis', 'positive regulation of long-term synaptic potentiation', 'positive regulation of mitotic cell cycle', 'positive regulation of monocyte chemotaxis', 'proteolysis', 'proteolysis involved in protein catabolic process', 'receptor catabolic process', 'renal system process', 'response to acidic pH', 'self proteolysis', 'vacuolar protein processing', 'vitamin D metabolic process']
Progesterone receptor
603
Progesterone receptor
609
6.9
65
0.22
P06401P06401['cell-cell signaling', 'glandular epithelial cell maturation', 'intracellular steroid hormone receptor signaling pathway', 'lung alveolus development', 'negative regulation of gene expression', 'ovulation from ovarian follicle', 'paracrine signaling', 'positive regulation of gene expression', 'positive regulation of transcription by RNA polymerase II', 'progesterone receptor signaling pathway', 'regulation of epithelial cell proliferation', 'regulation of transcription by RNA polymerase II', 'signal transduction', 'tertiary branching involved in mammary gland duct morphogenesis']['cell-cell signaling', 'glandular epithelial cell maturation', 'intracellular steroid hormone receptor signaling pathway', 'lung alveolus development', 'negative regulation of gene expression', 'ovulation from ovarian follicle', 'paracrine signaling', 'positive regulation of gene expression', 'positive regulation of transcription by RNA polymerase II', 'progesterone receptor signaling pathway', 'regulation of epithelial cell proliferation', 'regulation of transcription by RNA polymerase II', 'signal transduction', 'tertiary branching involved in mammary gland duct morphogenesis']
Glutaredoxin-related protein 5, mitochondrial
67
Glutaredoxin-related protein 5, mitochondrial
67
6.9
61
0.24
Q86SX6Q86SX6['[2Fe-2S] cluster assembly', 'cell redox homeostasis', 'hemopoiesis', 'iron ion homeostasis', 'iron-sulfur cluster assembly', 'protein maturation by [2Fe-2S] cluster transfer', 'protein maturation by [4Fe-4S] cluster transfer']['[2Fe-2S] cluster assembly', 'cell redox homeostasis', 'hemopoiesis', 'iron ion homeostasis', 'iron-sulfur cluster assembly', 'protein maturation by [2Fe-2S] cluster transfer', 'protein maturation by [4Fe-4S] cluster transfer']
Prostaglandin-H2 D-isomerase
89
Prostaglandin-H2 D-isomerase
89
6.9
73
0.2
P41222P41222['cyclooxygenase pathway', 'gene expression', 'mast cell degranulation', 'negative regulation of male germ cell proliferation', 'prostaglandin biosynthetic process', 'regulation of circadian sleep/wake cycle, sleep', 'response to glucocorticoid']['cyclooxygenase pathway', 'gene expression', 'mast cell degranulation', 'negative regulation of male germ cell proliferation', 'prostaglandin biosynthetic process', 'regulation of circadian sleep/wake cycle, sleep', 'response to glucocorticoid']
Gremlin-1
122
Gremlin-1
141
7.0
82
0.18
O60565O60565['animal organ morphogenesis', 'apoptotic process', 'cardiac muscle cell differentiation', 'cardiac muscle cell myoblast differentiation', 'cell migration involved in sprouting angiogenesis', 'cell morphogenesis', 'cell-cell signaling', 'collagen fibril organization', 'determination of dorsal identity', 'embryonic limb morphogenesis', 'limb development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'negative regulation of apoptotic process', 'negative regulation of BMP signaling pathway', 'negative regulation of bone mineralization', 'negative regulation of bone mineralization involved in bone maturation', 'negative regulation of bone remodeling', 'negative regulation of bone trabecula formation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell growth', 'negative regulation of chondrocyte differentiation', 'negative regulation of monocyte chemotaxis', 'negative regulation of osteoblast differentiation', 'negative regulation of osteoblast proliferation', 'negative regulation of osteoclast proliferation', 'negative regulation of pathway-restricted SMAD protein phosphorylation', 'negative regulation of transcription, DNA-templated', 'positive regulation of angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell population proliferation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of receptor internalization', 'positive regulation of signaling receptor activity', 'positive regulation of telomerase activity', 'positive regulation of transcription by RNA polymerase II', 'proximal/distal pattern formation', 'regulation of epithelial to mesenchymal transition', 'regulation of focal adhesion assembly', 'sequestering of BMP from receptor via BMP binding', 'signal transduction', 'ureteric bud formation']['animal organ morphogenesis', 'apoptotic process', 'cardiac muscle cell differentiation', 'cardiac muscle cell myoblast differentiation', 'cell migration involved in sprouting angiogenesis', 'cell morphogenesis', 'cell-cell signaling', 'collagen fibril organization', 'determination of dorsal identity', 'embryonic limb morphogenesis', 'limb development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'negative regulation of apoptotic process', 'negative regulation of BMP signaling pathway', 'negative regulation of bone mineralization', 'negative regulation of bone mineralization involved in bone maturation', 'negative regulation of bone remodeling', 'negative regulation of bone trabecula formation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell growth', 'negative regulation of chondrocyte differentiation', 'negative regulation of monocyte chemotaxis', 'negative regulation of osteoblast differentiation', 'negative regulation of osteoblast proliferation', 'negative regulation of osteoclast proliferation', 'negative regulation of pathway-restricted SMAD protein phosphorylation', 'negative regulation of transcription, DNA-templated', 'positive regulation of angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell population proliferation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of receptor internalization', 'positive regulation of signaling receptor activity', 'positive regulation of telomerase activity', 'positive regulation of transcription by RNA polymerase II', 'proximal/distal pattern formation', 'regulation of epithelial to mesenchymal transition', 'regulation of focal adhesion assembly', 'sequestering of BMP from receptor via BMP binding', 'signal transduction', 'ureteric bud formation']
Copper transport protein ATOX1
15
Copper-transporting ATPase 1
22
6.9
77
0.19
O00244Q04656['cellular copper ion homeostasis', 'copper ion transport', 'response to oxidative stress']['blood vessel development', 'blood vessel remodeling', 'cartilage development', 'catecholamine metabolic process', 'cellular copper ion homeostasis', 'cellular response to amino acid stimulus', 'cellular response to antibiotic', 'cellular response to cadmium ion', 'cellular response to cobalt ion', 'cellular response to copper ion', 'cellular response to hypoxia', 'cellular response to iron ion', 'cellular response to lead ion', 'cellular response to platelet-derived growth factor stimulus', 'central nervous system neuron development', 'cerebellar Purkinje cell differentiation', 'collagen fibril organization', 'copper ion export', 'copper ion homeostasis', 'copper ion import', 'copper ion transport', 'detoxification of copper ion', 'dopamine metabolic process', 'elastic fiber assembly', 'elastin biosynthetic process', 'epinephrine metabolic process', 'extracellular matrix organization', 'female pregnancy', 'hair follicle morphogenesis', 'in utero embryonic development', 'lactation', 'liver development', 'locomotory behavior', 'lung alveolus development', 'mitochondrion organization', 'negative regulation of iron ion transmembrane transport', 'neuron projection morphogenesis', 'norepinephrine metabolic process', 'peptidyl-lysine modification', 'pigmentation', 'positive regulation of catalytic activity', 'positive regulation of cell size', 'positive regulation of epithelial cell proliferation', 'positive regulation of lamellipodium assembly', 'positive regulation of melanin biosynthetic process', 'positive regulation of response to wounding', 'positive regulation of tyrosinase activity', 'positive regulation of vascular associated smooth muscle cell migration', 'pyramidal neuron development', 'regulation of cytochrome-c oxidase activity', 'regulation of gene expression', 'regulation of oxidative phosphorylation', 'removal of superoxide radicals', 'response to iron(III) ion', 'response to manganese ion', 'response to zinc ion', 'serotonin metabolic process', 'skin development', 'T-helper cell differentiation', 'tryptophan metabolic process']
Excision repair cross-complementing rodent repair deficiency, complementation group 6 variant
841
Excision repair cross-complementing rodent repair deficiency, complementation group 6 variant
841
2.0
50
0.98
Q59FF6Q59FF6[][]
Transforming growth factor beta-3 proprotein
377
Transforming growth factor beta-3 proprotein
377
2.0
91
0.54
P10600P10600['aging', 'BMP signaling pathway', 'cell-cell junction organization', 'detection of hypoxia', 'digestive tract development', 'embryonic neurocranium morphogenesis', 'face morphogenesis', 'female pregnancy', 'frontal suture morphogenesis', 'in utero embryonic development', 'inner ear development', 'lung alveolus development', 'mammary gland development', 'negative regulation of cell population proliferation', 'negative regulation of macrophage cytokine production', 'negative regulation of neuron apoptotic process', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of vascular associated smooth muscle cell proliferation', 'odontogenesis', 'ossification involved in bone remodeling', 'positive regulation of apoptotic process', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of filopodium assembly', 'positive regulation of MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stress fiber assembly', 'positive regulation of tight junction disassembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of cell population proliferation', 'response to estrogen', 'response to hypoxia', 'response to laminar fluid shear stress', 'response to progesterone', 'salivary gland morphogenesis', 'secondary palate development', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'wound healing']['aging', 'BMP signaling pathway', 'cell-cell junction organization', 'detection of hypoxia', 'digestive tract development', 'embryonic neurocranium morphogenesis', 'face morphogenesis', 'female pregnancy', 'frontal suture morphogenesis', 'in utero embryonic development', 'inner ear development', 'lung alveolus development', 'mammary gland development', 'negative regulation of cell population proliferation', 'negative regulation of macrophage cytokine production', 'negative regulation of neuron apoptotic process', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of vascular associated smooth muscle cell proliferation', 'odontogenesis', 'ossification involved in bone remodeling', 'positive regulation of apoptotic process', 'positive regulation of bone mineralization', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of filopodium assembly', 'positive regulation of MAPK cascade', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of SMAD protein signal transduction', 'positive regulation of stress fiber assembly', 'positive regulation of tight junction disassembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of cell population proliferation', 'response to estrogen', 'response to hypoxia', 'response to laminar fluid shear stress', 'response to progesterone', 'salivary gland morphogenesis', 'secondary palate development', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'uterine wall breakdown', 'wound healing']
Protein FosB
172
Transcription factor JunD
285
2.0
58
0.85
P53539P17535['cellular response to calcium ion', 'cellular response to hormone stimulus', 'female pregnancy', 'negative regulation of transcription by RNA polymerase II', 'regulation of transcription by RNA polymerase II', 'response to cAMP', 'response to corticosterone', 'response to mechanical stimulus', 'response to morphine', 'response to progesterone', 'response to xenobiotic stimulus', 'transcription by RNA polymerase II']['aging', 'cellular response to calcium ion', 'cellular response to hypoxia', 'circadian rhythm', 'negative regulation of transcription by RNA polymerase II', 'osteoblast development', 'positive regulation of macrophage activation', 'positive regulation of osteoblast differentiation', 'positive regulation of transcription by RNA polymerase II', 'regulation of cell cycle', 'regulation of cell population proliferation', 'regulation of transcription by RNA polymerase II', 'response to light stimulus', 'response to lipopolysaccharide', 'response to mechanical stimulus', 'response to organic cyclic compound', 'response to peptide hormone', 'transcription by RNA polymerase II']
E3 ubiquitin-protein ligase RNF31
890
E3 ubiquitin-protein ligase RNF31
885
7.2
61
0.23
Q96EP0Q96EP0['CD40 signaling pathway', 'defense response to bacterium', 'negative regulation of necroptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of xenophagy', 'protein linear polyubiquitination', 'protein polyubiquitination', 'T cell receptor signaling pathway']['CD40 signaling pathway', 'defense response to bacterium', 'negative regulation of necroptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of xenophagy', 'protein linear polyubiquitination', 'protein polyubiquitination', 'T cell receptor signaling pathway']
MORC family CW-type zinc finger protein 3
416
MORC family CW-type zinc finger protein 3
446
7.2
69
0.2
Q14149Q14149['innate immune response', 'maintenance of protein location in nucleus', 'negative regulation of fibroblast proliferation', 'peptidyl-serine phosphorylation', 'positive regulation of cellular senescence', 'post-embryonic development', 'protein phosphorylation', 'protein stabilization']['innate immune response', 'maintenance of protein location in nucleus', 'negative regulation of fibroblast proliferation', 'peptidyl-serine phosphorylation', 'positive regulation of cellular senescence', 'post-embryonic development', 'protein phosphorylation', 'protein stabilization']
C-C motif chemokine 13
58
C-C motif chemokine 13
34
6.8
63
0.23
Q99616Q99616['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytoskeleton organization', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'regulation of cell shape', 'signal transduction']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytoskeleton organization', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'regulation of cell shape', 'signal transduction']
Immunoglobulin heavy constant alpha 1
180
Immunoglobulin heavy constant alpha 1
180
6.8
44
0.33
P01876P01876['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
157
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
157
7.1
77
0.18
Q01064Q01064['cellular response to granulocyte macrophage colony-stimulating factor stimulus', 'cellular response to macrophage colony-stimulating factor stimulus', 'locomotory behavior', 'monocyte differentiation', 'regulation of dopamine metabolic process', 'regulation of neurotransmitter levels', 'response to amphetamine', 'serotonin metabolic process', 'signal transduction', 'visual learning']['cellular response to granulocyte macrophage colony-stimulating factor stimulus', 'cellular response to macrophage colony-stimulating factor stimulus', 'locomotory behavior', 'monocyte differentiation', 'regulation of dopamine metabolic process', 'regulation of neurotransmitter levels', 'response to amphetamine', 'serotonin metabolic process', 'signal transduction', 'visual learning']
Lysozyme C
99
Lysozyme C
99
7.2
91
0.15
P61626P61626['antimicrobial humoral response', 'cytolysis', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'inflammatory response', 'killing of cells of another organism', 'metabolic process', 'retina homeostasis']['antimicrobial humoral response', 'cytolysis', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'inflammatory response', 'killing of cells of another organism', 'metabolic process', 'retina homeostasis']
E3 ubiquitin-protein ligase UHRF1
321
E3 ubiquitin-protein ligase UHRF1
321
6.8
65
0.23
Q96T88Q96T88['cell cycle', 'chromatin organization', 'DNA repair', 'histone monoubiquitination', 'histone ubiquitination', 'maintenance of DNA methylation', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity', 'positive regulation of protein metabolic process', 'positive regulation of transcription by RNA polymerase II', 'protein autoubiquitination', 'protein ubiquitination', 'regulation of epithelial cell proliferation', 'ubiquitin-dependent protein catabolic process']['cell cycle', 'chromatin organization', 'DNA repair', 'histone monoubiquitination', 'histone ubiquitination', 'maintenance of DNA methylation', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity', 'positive regulation of protein metabolic process', 'positive regulation of transcription by RNA polymerase II', 'protein autoubiquitination', 'protein ubiquitination', 'regulation of epithelial cell proliferation', 'ubiquitin-dependent protein catabolic process']
Importin subunit beta-1
436
Importin subunit beta-1
436
6.8
78
0.19
P70168P70168['astral microtubule organization', 'establishment of mitotic spindle localization', 'establishment of protein localization', 'mitotic chromosome movement towards spindle pole', 'mitotic metaphase plate congression', 'mitotic spindle assembly', 'protein import into nucleus', 'Ran protein signal transduction', 'ribosomal protein import into nucleus', 'RNA import into nucleus']['astral microtubule organization', 'establishment of mitotic spindle localization', 'establishment of protein localization', 'mitotic chromosome movement towards spindle pole', 'mitotic metaphase plate congression', 'mitotic spindle assembly', 'protein import into nucleus', 'Ran protein signal transduction', 'ribosomal protein import into nucleus', 'RNA import into nucleus']
Transcription factor Dp-1
274
Transcription factor Dp-1
274
6.7
68
0.22
Q14186Q14186['anoikis', 'epidermis development', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of fat cell proliferation', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of G1/S transition of mitotic cell cycle', 'positive regulation of transcription by RNA polymerase II', 'regulation of DNA biosynthetic process', 'regulation of transcription by RNA polymerase II', 'regulation of transcription involved in G1/S transition of mitotic cell cycle', 'transcription by RNA polymerase II']['anoikis', 'epidermis development', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of fat cell proliferation', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of G1/S transition of mitotic cell cycle', 'positive regulation of transcription by RNA polymerase II', 'regulation of DNA biosynthetic process', 'regulation of transcription by RNA polymerase II', 'regulation of transcription involved in G1/S transition of mitotic cell cycle', 'transcription by RNA polymerase II']
Inosine triphosphate pyrophosphatase
146
Inosine triphosphate pyrophosphatase
146
6.8
78
0.19
Q9BY32Q9BY32['chromosome organization', 'deoxyribonucleoside triphosphate catabolic process', 'ITP catabolic process', 'nucleoside triphosphate catabolic process']['chromosome organization', 'deoxyribonucleoside triphosphate catabolic process', 'ITP catabolic process', 'nucleoside triphosphate catabolic process']
Glutaredoxin-2, mitochondrial
77
Glutaredoxin-2, mitochondrial
77
6.8
56
0.26
Q9NS18Q9NS18['aging', 'apoptotic process', 'cell differentiation', 'cell redox homeostasis', 'cellular response to superoxide', 'DNA protection', 'glutathione metabolic process', 'regulation of signal transduction', 'regulation of transcription, DNA-templated', 'response to hydrogen peroxide', 'response to organic substance', 'response to redox state', 'response to temperature stimulus']['aging', 'apoptotic process', 'cell differentiation', 'cell redox homeostasis', 'cellular response to superoxide', 'DNA protection', 'glutathione metabolic process', 'regulation of signal transduction', 'regulation of transcription, DNA-templated', 'response to hydrogen peroxide', 'response to organic substance', 'response to redox state', 'response to temperature stimulus']
Pancreatic secretory granule membrane major glycoprotein GP2
146
Pancreatic secretory granule membrane major glycoprotein GP2
172
6.7
71
0.21
P55259P55259['antigen transcytosis by M cells in mucosal-associated lymphoid tissue', 'innate immune response', 'neutrophil migration']['antigen transcytosis by M cells in mucosal-associated lymphoid tissue', 'innate immune response', 'neutrophil migration']
Dopamine beta-hydroxylase
528
Dopamine beta-hydroxylase
530
2.0
33
1.49
P09172P09172['behavioral response to ethanol', 'blood vessel remodeling', 'chemical synaptic transmission', 'dopamine catabolic process', 'fear response', 'glucose homeostasis', 'homoiothermy', 'leukocyte mediated immunity', 'leukocyte migration', 'locomotory behavior', 'maternal behavior', 'memory', 'norepinephrine biosynthetic process', 'octopamine biosynthetic process', 'positive regulation of cold-induced thermogenesis', 'positive regulation of vasoconstriction', 'regulation of extrinsic apoptotic signaling pathway', 'regulation of vascular associated smooth muscle cell proliferation', 'regulation of vascular endothelial cell proliferation', 'response to amphetamine', 'response to pain', 'vasoconstriction', 'visual learning']['behavioral response to ethanol', 'blood vessel remodeling', 'chemical synaptic transmission', 'dopamine catabolic process', 'fear response', 'glucose homeostasis', 'homoiothermy', 'leukocyte mediated immunity', 'leukocyte migration', 'locomotory behavior', 'maternal behavior', 'memory', 'norepinephrine biosynthetic process', 'octopamine biosynthetic process', 'positive regulation of cold-induced thermogenesis', 'positive regulation of vasoconstriction', 'regulation of extrinsic apoptotic signaling pathway', 'regulation of vascular associated smooth muscle cell proliferation', 'regulation of vascular endothelial cell proliferation', 'response to amphetamine', 'response to pain', 'vasoconstriction', 'visual learning']
cDNA FLJ56409, highly similar to Serine/threonine-protein kinase Chk1
424
cDNA FLJ56409, highly similar to Serine/threonine-protein kinase Chk1
424
2.0
45
1.1
B4DT73B4DT73['protein phosphorylation']['protein phosphorylation']
Peroxiredoxin-4
245
Endoplasmic reticulum resident protein 44
58
2.0
78
0.63
Q13162Q9BS26['cell redox homeostasis', 'extracellular matrix organization', 'I-kappaB phosphorylation', 'male gonad development', 'negative regulation of male germ cell proliferation', 'peptidyl-proline hydroxylation to 4-hydroxy-L-proline', 'protein maturation by protein folding', 'reactive oxygen species metabolic process', 'response to oxidative stress', 'spermatogenesis']['cell redox homeostasis', 'glycoprotein metabolic process', 'protein folding', 'response to endoplasmic reticulum stress', 'response to unfolded protein']
Receptor-interacting serine/threonine-protein kinase 3
234
Receptor-interacting serine/threonine-protein kinase 3
234
2.0
57
0.86
Q9Y572Q9Y572['activation of protein kinase activity', 'amyloid fibril formation', 'apoptotic signaling pathway', 'cellular response to hydrogen peroxide', 'defense response to virus', 'execution phase of necroptosis', 'I-kappaB kinase/NF-kappaB signaling', 'lymph node development', 'necroptotic process', 'necroptotic signaling pathway', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of ligase activity', 'positive regulation of necroptotic process', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of oxidoreductase activity', 'positive regulation of phosphatase activity', 'positive regulation of reactive oxygen species metabolic process', 'programmed necrotic cell death', 'protein autophosphorylation', 'protein modification process', 'reactive oxygen species metabolic process', 'regulation of activated T cell proliferation', 'regulation of activation-induced cell death of T cells', 'regulation of adaptive immune response', 'regulation of apoptotic process', 'regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation', 'regulation of interferon-gamma production', 'regulation of T cell mediated cytotoxicity', 'signal transduction', 'spleen development', 'T cell differentiation in thymus', 'T cell homeostasis', 'thymus development']['activation of protein kinase activity', 'amyloid fibril formation', 'apoptotic signaling pathway', 'cellular response to hydrogen peroxide', 'defense response to virus', 'execution phase of necroptosis', 'I-kappaB kinase/NF-kappaB signaling', 'lymph node development', 'necroptotic process', 'necroptotic signaling pathway', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of ligase activity', 'positive regulation of necroptotic process', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of oxidoreductase activity', 'positive regulation of phosphatase activity', 'positive regulation of reactive oxygen species metabolic process', 'programmed necrotic cell death', 'protein autophosphorylation', 'protein modification process', 'reactive oxygen species metabolic process', 'regulation of activated T cell proliferation', 'regulation of activation-induced cell death of T cells', 'regulation of adaptive immune response', 'regulation of apoptotic process', 'regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation', 'regulation of interferon-gamma production', 'regulation of T cell mediated cytotoxicity', 'signal transduction', 'spleen development', 'T cell differentiation in thymus', 'T cell homeostasis', 'thymus development']
Medulloblastoma antigen MU-MB-50.72
96
Medulloblastoma antigen MU-MB-50.72
100
2.0
60
0.82
Q7Z5E2Q7Z5E2[][]
IGL@ protein
234
IGL@ protein
234
2.0
29
1.7
Q6PIK1Q6PIK1[][]
Vesicle-associated membrane protein-associated protein A
60
Vesicle-associated membrane protein-associated protein A
60
2.0
82
0.6
Q9P0L0Q9P0L0['cell death', 'ceramide transport', 'COPII-coated vesicle budding', 'endoplasmic reticulum to Golgi vesicle-mediated transport', 'membrane fusion', 'negative regulation by host of viral genome replication', 'neuron projection development', 'phospholipid transport', 'positive regulation by host of viral genome replication', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'protein localization to endoplasmic reticulum', 'sphingomyelin biosynthetic process', 'sterol transport', 'viral release from host cell']['cell death', 'ceramide transport', 'COPII-coated vesicle budding', 'endoplasmic reticulum to Golgi vesicle-mediated transport', 'membrane fusion', 'negative regulation by host of viral genome replication', 'neuron projection development', 'phospholipid transport', 'positive regulation by host of viral genome replication', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'protein localization to endoplasmic reticulum', 'sphingomyelin biosynthetic process', 'sterol transport', 'viral release from host cell']
Dual specificity protein phosphatase 26
59
Dual specificity protein phosphatase 26
59
2.0
53
0.93
Q9BV47Q9BV47['negative regulation of ERK1 and ERK2 cascade', 'negative regulation of MAPK cascade', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of cell adhesion', 'protein dephosphorylation']['negative regulation of ERK1 and ERK2 cascade', 'negative regulation of MAPK cascade', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of cell adhesion', 'protein dephosphorylation']
HECT-type E3 ubiquitin transferase
4169
HECT-type E3 ubiquitin transferase
4169
2.0
56
0.88
A0A024R9Y3A0A024R9Y3['DNA repair']['DNA repair']
Transcription intermediary factor 1-alpha
917
Transcription intermediary factor 1-alpha
917
2.0
55
0.9
O15164O15164['calcium ion homeostasis', 'cellular response to estrogen stimulus', 'epithelial cell proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of transcription, DNA-templated', 'positive regulation of gene expression', 'protein autophosphorylation', 'protein catabolic process', 'protein ubiquitination', 'regulation of apoptotic process', 'regulation of protein stability', 'regulation of signal transduction by p53 class mediator', 'regulation of vitamin D receptor signaling pathway', 'transcription by RNA polymerase II']['calcium ion homeostasis', 'cellular response to estrogen stimulus', 'epithelial cell proliferation', 'negative regulation of epithelial cell proliferation', 'negative regulation of transcription, DNA-templated', 'positive regulation of gene expression', 'protein autophosphorylation', 'protein catabolic process', 'protein ubiquitination', 'regulation of apoptotic process', 'regulation of protein stability', 'regulation of signal transduction by p53 class mediator', 'regulation of vitamin D receptor signaling pathway', 'transcription by RNA polymerase II']
Mitogen-activated protein kinase 14
119
Mitogen-activated protein kinase 14
119
2.0
55
0.9
Q16539Q16539["3'-UTR-mediated mRNA stabilization", 'angiogenesis', 'apoptotic process', 'bone development', 'cartilage condensation', 'cell morphogenesis', 'cell surface receptor signaling pathway', 'cellular response to ionizing radiation', 'cellular response to lipopolysaccharide', 'cellular response to lipoteichoic acid', 'cellular response to tumor necrosis factor', 'cellular response to vascular endothelial growth factor stimulus', 'cellular response to virus', 'cellular senescence', 'chemotaxis', 'chondrocyte differentiation', 'DNA damage checkpoint signaling', 'fatty acid oxidation', 'glucose import', 'glucose metabolic process', 'intracellular signal transduction', 'lipopolysaccharide-mediated signaling pathway', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of hippo signaling', 'negative regulation of inflammatory response to antigenic stimulus', 'osteoblast differentiation', 'osteoclast differentiation', 'p38MAPK cascade', 'peptidyl-serine phosphorylation', 'placenta development', 'platelet activation', 'positive regulation of brown fat cell differentiation', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cyclase activity', 'positive regulation of erythrocyte differentiation', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of interleukin-12 production', 'positive regulation of muscle cell differentiation', 'positive regulation of myoblast differentiation', 'positive regulation of myoblast fusion', 'positive regulation of myotube differentiation', 'positive regulation of protein import into nucleus', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of cytokine production involved in inflammatory response', 'regulation of ossification', 'regulation of synaptic membrane adhesion', 'regulation of transcription by RNA polymerase II', 'response to dietary excess', 'response to insulin', 'response to muramyl dipeptide', 'response to muscle stretch', 'signal transduction', 'signal transduction in response to DNA damage', 'skeletal muscle tissue development', 'stem cell differentiation', 'stress-induced premature senescence', 'striated muscle cell differentiation', 'transcription by RNA polymerase II', 'transmembrane receptor protein serine/threonine kinase signaling pathway', 'vascular endothelial growth factor receptor signaling pathway']["3'-UTR-mediated mRNA stabilization", 'angiogenesis', 'apoptotic process', 'bone development', 'cartilage condensation', 'cell morphogenesis', 'cell surface receptor signaling pathway', 'cellular response to ionizing radiation', 'cellular response to lipopolysaccharide', 'cellular response to lipoteichoic acid', 'cellular response to tumor necrosis factor', 'cellular response to vascular endothelial growth factor stimulus', 'cellular response to virus', 'cellular senescence', 'chemotaxis', 'chondrocyte differentiation', 'DNA damage checkpoint signaling', 'fatty acid oxidation', 'glucose import', 'glucose metabolic process', 'intracellular signal transduction', 'lipopolysaccharide-mediated signaling pathway', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of hippo signaling', 'negative regulation of inflammatory response to antigenic stimulus', 'osteoblast differentiation', 'osteoclast differentiation', 'p38MAPK cascade', 'peptidyl-serine phosphorylation', 'placenta development', 'platelet activation', 'positive regulation of brown fat cell differentiation', 'positive regulation of cardiac muscle cell proliferation', 'positive regulation of cyclase activity', 'positive regulation of erythrocyte differentiation', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of interleukin-12 production', 'positive regulation of muscle cell differentiation', 'positive regulation of myoblast differentiation', 'positive regulation of myoblast fusion', 'positive regulation of myotube differentiation', 'positive regulation of protein import into nucleus', 'positive regulation of reactive oxygen species metabolic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of cytokine production involved in inflammatory response', 'regulation of ossification', 'regulation of synaptic membrane adhesion', 'regulation of transcription by RNA polymerase II', 'response to dietary excess', 'response to insulin', 'response to muramyl dipeptide', 'response to muscle stretch', 'signal transduction', 'signal transduction in response to DNA damage', 'skeletal muscle tissue development', 'stem cell differentiation', 'stress-induced premature senescence', 'striated muscle cell differentiation', 'transcription by RNA polymerase II', 'transmembrane receptor protein serine/threonine kinase signaling pathway', 'vascular endothelial growth factor receptor signaling pathway']
Complement C4-A
876
Complement C4-B
1590
2.0
76
0.65
P0C0L4P0C0L5['complement activation', 'complement activation, classical pathway', 'inflammatory response', 'innate immune response', 'positive regulation of apoptotic cell clearance', 'positive regulation of immune response', 'positive regulation of opsonization']['complement activation', 'complement activation, classical pathway', 'detection of molecule of bacterial origin', 'inflammatory response', 'innate immune response', 'opsonization', 'positive regulation of apoptotic cell clearance', 'positive regulation of immune response', 'positive regulation of opsonization']
APOBEC3H
73
APOBEC3H
73
2.0
68
0.72
B7TQM8B7TQM8[][]
BTB/POZ domain-containing protein KCTD8
238
BTB/POZ domain-containing protein KCTD8
238
2.0
94
0.52
Q6ZWB6Q6ZWB6['protein homooligomerization', 'regulation of G protein-coupled receptor signaling pathway']['protein homooligomerization', 'regulation of G protein-coupled receptor signaling pathway']
Insulin receptor
551
Insulin receptor
551
2.0
74
0.67
P06213P06213['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell']['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell']
Prostaglandin E synthase 3
58
Prostaglandin E synthase 3
58
2.0
86
0.57
Q15185Q15185['chaperone cofactor-dependent protein refolding', 'chaperone-mediated protein complex assembly', 'cyclooxygenase pathway', 'fibroblast proliferation', 'glucocorticoid receptor signaling pathway', 'glycogen biosynthetic process', 'lung saccule development', 'positive regulation of phosphorylation', 'positive regulation of telomerase activity', 'prostaglandin biosynthetic process', 'protein folding', 'protein stabilization', 'signal transduction', 'skin development', 'telomerase holoenzyme complex assembly', 'telomere maintenance', 'telomere maintenance via telomerase']['chaperone cofactor-dependent protein refolding', 'chaperone-mediated protein complex assembly', 'cyclooxygenase pathway', 'fibroblast proliferation', 'glucocorticoid receptor signaling pathway', 'glycogen biosynthetic process', 'lung saccule development', 'positive regulation of phosphorylation', 'positive regulation of telomerase activity', 'prostaglandin biosynthetic process', 'protein folding', 'protein stabilization', 'signal transduction', 'skin development', 'telomerase holoenzyme complex assembly', 'telomere maintenance', 'telomere maintenance via telomerase']
Interferon lambda-3
69
Interferon lambda-3
69
2.0
60
0.82
Q8IZI9Q8IZI9['cellular response to virus', 'defense response to virus', 'innate immune response', 'negative regulation of viral genome replication', 'positive regulation of immune response', 'receptor signaling pathway via JAK-STAT', 'type III interferon signaling pathway']['cellular response to virus', 'defense response to virus', 'innate immune response', 'negative regulation of viral genome replication', 'positive regulation of immune response', 'receptor signaling pathway via JAK-STAT', 'type III interferon signaling pathway']
Golgi reassembly-stacking protein 2
103
Golgin-45
396
3.9
66
0.38
Q99JX3Q8R2X8['cell differentiation', 'establishment of protein localization to plasma membrane', 'Golgi organization', 'organelle assembly', 'organelle organization', 'response to endoplasmic reticulum stress', 'spermatogenesis']['Golgi organization', 'Golgi to plasma membrane protein transport']
Nitric oxide synthase, endothelial
94
Nitric oxide synthase, endothelial
94
3.9
60
0.42
P29474P29474['angiogenesis', 'aortic valve morphogenesis', 'arginine catabolic process', 'blood vessel diameter maintenance', 'blood vessel remodeling', 'calcium ion transport', 'cell redox homeostasis', 'endocardial cushion morphogenesis', 'endothelial cell migration', 'establishment of localization in cell', 'homeostasis of number of cells within a tissue', 'in utero embryonic development', 'lipopolysaccharide-mediated signaling pathway', 'lung development', 'mitochondrion organization', 'negative regulation of biomineral tissue development', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of cell population proliferation', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrolase activity', 'negative regulation of muscle hyperplasia', 'negative regulation of platelet activation', 'negative regulation of potassium ion transport', 'negative regulation of smooth muscle cell proliferation', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'ovulation from ovarian follicle', 'positive regulation of angiogenesis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of gene expression', 'positive regulation of guanylate cyclase activity', 'positive regulation of Notch signaling pathway', 'potassium ion transport', 'pulmonary valve morphogenesis', 'regulation of blood pressure', 'regulation of nervous system process', 'regulation of sodium ion transport', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of the force of heart contraction by chemical signal', 'removal of superoxide radicals', 'response to fluid shear stress', 'response to heat', 'response to hormone', 'response to lipopolysaccharide', 'smooth muscle hyperplasia', 'vasodilation', 'ventricular septum morphogenesis']['angiogenesis', 'aortic valve morphogenesis', 'arginine catabolic process', 'blood vessel diameter maintenance', 'blood vessel remodeling', 'calcium ion transport', 'cell redox homeostasis', 'endocardial cushion morphogenesis', 'endothelial cell migration', 'establishment of localization in cell', 'homeostasis of number of cells within a tissue', 'in utero embryonic development', 'lipopolysaccharide-mediated signaling pathway', 'lung development', 'mitochondrion organization', 'negative regulation of biomineral tissue development', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of cell population proliferation', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrolase activity', 'negative regulation of muscle hyperplasia', 'negative regulation of platelet activation', 'negative regulation of potassium ion transport', 'negative regulation of smooth muscle cell proliferation', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'ovulation from ovarian follicle', 'positive regulation of angiogenesis', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of gene expression', 'positive regulation of guanylate cyclase activity', 'positive regulation of Notch signaling pathway', 'potassium ion transport', 'pulmonary valve morphogenesis', 'regulation of blood pressure', 'regulation of nervous system process', 'regulation of sodium ion transport', 'regulation of systemic arterial blood pressure by endothelin', 'regulation of the force of heart contraction by chemical signal', 'removal of superoxide radicals', 'response to fluid shear stress', 'response to heat', 'response to hormone', 'response to lipopolysaccharide', 'smooth muscle hyperplasia', 'vasodilation', 'ventricular septum morphogenesis']
Nitric oxide synthase, inducible
110
Nitric oxide synthase, inducible
110
3.9
71
0.36
P35228P35228['arginine catabolic process', 'cell redox homeostasis', 'cellular response to interferon-gamma', 'cellular response to lipopolysaccharide', 'cellular response to xenobiotic stimulus', 'circadian rhythm', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'inflammatory response', 'innate immune response in mucosa', 'negative regulation of blood pressure', 'negative regulation of gene expression', 'negative regulation of protein catabolic process', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of guanylate cyclase activity', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of killing of cells of another organism', 'positive regulation of leukocyte mediated cytotoxicity', 'prostaglandin secretion', 'regulation of cell population proliferation', 'regulation of cellular respiration', 'regulation of cytokine production involved in inflammatory response', 'regulation of insulin secretion', 'response to bacterium', 'response to hormone', 'response to hypoxia', 'response to lipopolysaccharide', 'superoxide metabolic process']['arginine catabolic process', 'cell redox homeostasis', 'cellular response to interferon-gamma', 'cellular response to lipopolysaccharide', 'cellular response to xenobiotic stimulus', 'circadian rhythm', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'inflammatory response', 'innate immune response in mucosa', 'negative regulation of blood pressure', 'negative regulation of gene expression', 'negative regulation of protein catabolic process', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of guanylate cyclase activity', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of killing of cells of another organism', 'positive regulation of leukocyte mediated cytotoxicity', 'prostaglandin secretion', 'regulation of cell population proliferation', 'regulation of cellular respiration', 'regulation of cytokine production involved in inflammatory response', 'regulation of insulin secretion', 'response to bacterium', 'response to hormone', 'response to hypoxia', 'response to lipopolysaccharide', 'superoxide metabolic process']
Nitric-oxide synthase (NADPH)
99
Nitric-oxide synthase (NADPH)
94
3.9
76
0.33
A0S0A6A0S0A6['nitric oxide biosynthetic process']['nitric oxide biosynthetic process']
F-box only protein 11
888
F-box only protein 11
868
3.9
62
0.41
Q86XK2Q86XK2['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']
Nitric oxide synthase, brain
326
Nitric oxide synthase, brain
326
3.9
62
0.41
P29476P29476['aging', 'arginine catabolic process', 'behavioral response to cocaine', 'brain development', 'cellular response to epinephrine stimulus', 'cellular response to growth factor stimulus', 'cellular response to mechanical stimulus', 'establishment of protein localization', 'female pregnancy', 'multicellular organismal response to stress', 'muscle contraction', 'negative regulation of apoptotic process', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of cell population proliferation', 'negative regulation of cytosolic calcium ion concentration', 'negative regulation of heart contraction', 'negative regulation of hepatic stellate cell contraction', 'negative regulation of hydrolase activity', 'negative regulation of insulin secretion', 'negative regulation of iron ion transmembrane transport', 'negative regulation of neuron apoptotic process', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of potassium ion transport', 'negative regulation of serotonin uptake', 'negative regulation of vasoconstriction', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'positive regulation of guanylate cyclase activity', 'positive regulation of histone acetylation', 'positive regulation of long-term synaptic potentiation', 'positive regulation of neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of sodium ion transmembrane transport', 'positive regulation of the force of heart contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of heart contraction', 'regulation of neurogenesis', 'regulation of sensory perception of pain', 'regulation of sodium ion transport', 'response to activity', 'response to estrogen', 'response to ethanol', 'response to heat', 'response to hormone', 'response to hypoxia', 'response to lead ion', 'response to lipopolysaccharide', 'response to nicotine', 'response to nitric oxide', 'response to nutrient levels', 'response to organic cyclic compound', 'response to organonitrogen compound', 'response to peptide hormone', 'response to vitamin E', 'retrograde trans-synaptic signaling by nitric oxide', 'striated muscle contraction', 'synaptic signaling by nitric oxide', 'vasodilation', 'xenobiotic catabolic process']['aging', 'arginine catabolic process', 'behavioral response to cocaine', 'brain development', 'cellular response to epinephrine stimulus', 'cellular response to growth factor stimulus', 'cellular response to mechanical stimulus', 'establishment of protein localization', 'female pregnancy', 'multicellular organismal response to stress', 'muscle contraction', 'negative regulation of apoptotic process', 'negative regulation of blood pressure', 'negative regulation of calcium ion transport', 'negative regulation of cell population proliferation', 'negative regulation of cytosolic calcium ion concentration', 'negative regulation of heart contraction', 'negative regulation of hepatic stellate cell contraction', 'negative regulation of hydrolase activity', 'negative regulation of insulin secretion', 'negative regulation of iron ion transmembrane transport', 'negative regulation of neuron apoptotic process', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of potassium ion transport', 'negative regulation of serotonin uptake', 'negative regulation of vasoconstriction', 'nitric oxide biosynthetic process', 'nitric oxide mediated signal transduction', 'peptidyl-cysteine S-nitrosylation', 'positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'positive regulation of guanylate cyclase activity', 'positive regulation of histone acetylation', 'positive regulation of long-term synaptic potentiation', 'positive regulation of neuron death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of sodium ion transmembrane transport', 'positive regulation of the force of heart contraction', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of heart contraction', 'regulation of neurogenesis', 'regulation of sensory perception of pain', 'regulation of sodium ion transport', 'response to activity', 'response to estrogen', 'response to ethanol', 'response to heat', 'response to hormone', 'response to hypoxia', 'response to lead ion', 'response to lipopolysaccharide', 'response to nicotine', 'response to nitric oxide', 'response to nutrient levels', 'response to organic cyclic compound', 'response to organonitrogen compound', 'response to peptide hormone', 'response to vitamin E', 'retrograde trans-synaptic signaling by nitric oxide', 'striated muscle contraction', 'synaptic signaling by nitric oxide', 'vasodilation', 'xenobiotic catabolic process']
Thymidylate synthase
174
Thymidylate synthase
174
3.9
91
0.28
P07607P07607['aging', 'cartilage development', 'circadian rhythm', 'developmental growth', 'dTMP biosynthetic process', 'dTTP biosynthetic process', 'intestinal epithelial cell maturation', 'liver regeneration', 'methylation', 'negative regulation of translation', 'regulation of translation', 'response to cytokine', 'response to ethanol', 'response to folic acid', 'response to glucocorticoid', 'response to organophosphorus', 'response to progesterone', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'tetrahydrofolate interconversion', 'uracil metabolic process']['aging', 'cartilage development', 'circadian rhythm', 'developmental growth', 'dTMP biosynthetic process', 'dTTP biosynthetic process', 'intestinal epithelial cell maturation', 'liver regeneration', 'methylation', 'negative regulation of translation', 'regulation of translation', 'response to cytokine', 'response to ethanol', 'response to folic acid', 'response to glucocorticoid', 'response to organophosphorus', 'response to progesterone', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'tetrahydrofolate interconversion', 'uracil metabolic process']
Integrin alpha-X
712
Integrin alpha-X
712
3.9
73
0.35
P20702P20702['animal organ morphogenesis', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell-cell adhesion', 'cell-matrix adhesion', 'defense response to virus', 'heterotypic cell-cell adhesion', 'integrin-mediated signaling pathway', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of endothelial tube morphogenesis', 'positive regulation of gene expression', 'positive regulation of myelination']['animal organ morphogenesis', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell-cell adhesion', 'cell-matrix adhesion', 'defense response to virus', 'heterotypic cell-cell adhesion', 'integrin-mediated signaling pathway', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of endothelial tube morphogenesis', 'positive regulation of gene expression', 'positive regulation of myelination']
F-box only protein 11
868
F-box only protein 11
890
3.9
67
0.38
Q86XK2Q86XK2['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']['protein modification process', 'protein ubiquitination', 'regulation of apoptotic process', 'sensory perception of sound', 'ubiquitin-dependent protein catabolic process']
Mast/stem cell growth factor receptor Kit
674
Mast/stem cell growth factor receptor Kit
674
3.9
65
0.39
P10721P10721['actin cytoskeleton reorganization', 'B cell differentiation', 'cell chemotaxis', 'cellular response to thyroid hormone stimulus', 'cytokine-mediated signaling pathway', 'detection of mechanical stimulus involved in sensory perception of sound', 'digestive tract development', 'ectopic germ cell programmed cell death', 'embryonic hemopoiesis', 'epithelial cell proliferation', 'erythrocyte differentiation', 'erythropoietin-mediated signaling pathway', 'Fc receptor signaling pathway', 'germ cell migration', 'glycosphingolipid metabolic process', 'hematopoietic progenitor cell differentiation', 'hematopoietic stem cell migration', 'hemopoiesis', 'immature B cell differentiation', 'inflammatory response', 'intracellular signal transduction', 'Kit signaling pathway', 'lamellipodium assembly', 'lymphoid progenitor cell differentiation', 'male gonad development', 'mast cell chemotaxis', 'mast cell degranulation', 'mast cell differentiation', 'mast cell proliferation', 'megakaryocyte development', 'melanocyte adhesion', 'melanocyte differentiation', 'melanocyte migration', 'myeloid progenitor cell differentiation', 'negative regulation of developmental process', 'negative regulation of programmed cell death', 'negative regulation of reproductive process', 'ovarian follicle development', 'pigmentation', 'positive regulation of cell migration', 'positive regulation of colon smooth muscle contraction', 'positive regulation of dendritic cell cytokine production', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of kinase activity', 'positive regulation of long-term neuronal synaptic plasticity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell cytokine production', 'positive regulation of mast cell proliferation', 'positive regulation of Notch signaling pathway', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phospholipase C activity', 'positive regulation of pseudopodium assembly', 'positive regulation of pyloric antrum smooth muscle contraction', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of small intestine smooth muscle contraction', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of vascular associated smooth muscle cell differentiation', 'protein autophosphorylation', 'regulation of bile acid metabolic process', 'regulation of cell population proliferation', 'regulation of cell shape', 'response to cadmium ion', 'signal transduction', 'somatic stem cell division', 'somatic stem cell population maintenance', 'spermatid development', 'spermatogenesis', 'stem cell differentiation', 'stem cell population maintenance', 'T cell differentiation', 'tongue development', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'visual learning']['actin cytoskeleton reorganization', 'B cell differentiation', 'cell chemotaxis', 'cellular response to thyroid hormone stimulus', 'cytokine-mediated signaling pathway', 'detection of mechanical stimulus involved in sensory perception of sound', 'digestive tract development', 'ectopic germ cell programmed cell death', 'embryonic hemopoiesis', 'epithelial cell proliferation', 'erythrocyte differentiation', 'erythropoietin-mediated signaling pathway', 'Fc receptor signaling pathway', 'germ cell migration', 'glycosphingolipid metabolic process', 'hematopoietic progenitor cell differentiation', 'hematopoietic stem cell migration', 'hemopoiesis', 'immature B cell differentiation', 'inflammatory response', 'intracellular signal transduction', 'Kit signaling pathway', 'lamellipodium assembly', 'lymphoid progenitor cell differentiation', 'male gonad development', 'mast cell chemotaxis', 'mast cell degranulation', 'mast cell differentiation', 'mast cell proliferation', 'megakaryocyte development', 'melanocyte adhesion', 'melanocyte differentiation', 'melanocyte migration', 'myeloid progenitor cell differentiation', 'negative regulation of developmental process', 'negative regulation of programmed cell death', 'negative regulation of reproductive process', 'ovarian follicle development', 'pigmentation', 'positive regulation of cell migration', 'positive regulation of colon smooth muscle contraction', 'positive regulation of dendritic cell cytokine production', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of kinase activity', 'positive regulation of long-term neuronal synaptic plasticity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mast cell cytokine production', 'positive regulation of mast cell proliferation', 'positive regulation of Notch signaling pathway', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phospholipase C activity', 'positive regulation of pseudopodium assembly', 'positive regulation of pyloric antrum smooth muscle contraction', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of small intestine smooth muscle contraction', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of vascular associated smooth muscle cell differentiation', 'protein autophosphorylation', 'regulation of bile acid metabolic process', 'regulation of cell population proliferation', 'regulation of cell shape', 'response to cadmium ion', 'signal transduction', 'somatic stem cell division', 'somatic stem cell population maintenance', 'spermatid development', 'spermatogenesis', 'stem cell differentiation', 'stem cell population maintenance', 'T cell differentiation', 'tongue development', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'visual learning']
E3 ubiquitin-protein ligase CBL-C
189
E3 ubiquitin-protein ligase CBL-C
202
3.9
73
0.35
Q9ULV8Q9ULV8['cell surface receptor signaling pathway', 'negative regulation of epidermal growth factor receptor signaling pathway', 'negative regulation of epidermal growth factor-activated receptor activity', 'negative regulation of MAP kinase activity', 'protein ubiquitination', 'signal transduction', 'ubiquitin-dependent protein catabolic process']['cell surface receptor signaling pathway', 'negative regulation of epidermal growth factor receptor signaling pathway', 'negative regulation of epidermal growth factor-activated receptor activity', 'negative regulation of MAP kinase activity', 'protein ubiquitination', 'signal transduction', 'ubiquitin-dependent protein catabolic process']
Nitric-oxide synthase (NADPH)
94
Nitric-oxide synthase (NADPH)
94
4.0
63
0.4
A0S0A6A0S0A6['nitric oxide biosynthetic process']['nitric oxide biosynthetic process']
Norrin
93
Norrin
93
4.0
75
0.33
Q00604Q00604['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']
LINE-1 retrotransposable element ORF1 protein
104
LINE-1 retrotransposable element ORF1 protein
104
4.0
64
0.39
Q9UN81Q9UN81['transposition, RNA-mediated']['transposition, RNA-mediated']
Poly(A)-specific ribonuclease PARN
108
Poly(A)-specific ribonuclease PARN
108
4.0
77
0.32
Q8VDG3Q8VDG3["box H/ACA RNA 3'-end processing", 'miRNA catabolic process', 'ncRNA deadenylation', 'nuclear-transcribed mRNA catabolic process, nonsense-mediated decay', 'nuclear-transcribed mRNA poly(A) tail shortening', "polyadenylation-dependent snoRNA 3'-end processing", 'positive regulation of telomerase activity', 'positive regulation of telomere maintenance via telomerase', 'regulation of telomerase RNA localization to Cajal body', 'RNA phosphodiester bond hydrolysis, exonucleolytic', 'telomerase RNA stabilization']["box H/ACA RNA 3'-end processing", 'miRNA catabolic process', 'ncRNA deadenylation', 'nuclear-transcribed mRNA catabolic process, nonsense-mediated decay', 'nuclear-transcribed mRNA poly(A) tail shortening', "polyadenylation-dependent snoRNA 3'-end processing", 'positive regulation of telomerase activity', 'positive regulation of telomere maintenance via telomerase', 'regulation of telomerase RNA localization to Cajal body', 'RNA phosphodiester bond hydrolysis, exonucleolytic', 'telomerase RNA stabilization']
Phosphatidylinositol 3-kinase regulatory subunit beta
396
Phosphatidylinositol 3-kinase regulatory subunit beta
396
4.0
68
0.36
O00459O00459['B cell differentiation', 'cellular glucose homeostasis', 'cellular response to insulin stimulus', 'immune response', 'insulin receptor signaling pathway', 'negative regulation of MAPK cascade', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol phosphate biosynthetic process', 'positive regulation of cell adhesion', 'positive regulation of protein import into nucleus', 'positive regulation of transcription by RNA polymerase II', 'protein transport', 'regulation of actin filament polymerization', 'regulation of autophagy', 'regulation of phosphatidylinositol 3-kinase activity', 'regulation of protein localization to plasma membrane', 'regulation of stress fiber assembly', 'response to endoplasmic reticulum stress', 'T cell differentiation']['B cell differentiation', 'cellular glucose homeostasis', 'cellular response to insulin stimulus', 'immune response', 'insulin receptor signaling pathway', 'negative regulation of MAPK cascade', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol phosphate biosynthetic process', 'positive regulation of cell adhesion', 'positive regulation of protein import into nucleus', 'positive regulation of transcription by RNA polymerase II', 'protein transport', 'regulation of actin filament polymerization', 'regulation of autophagy', 'regulation of phosphatidylinositol 3-kinase activity', 'regulation of protein localization to plasma membrane', 'regulation of stress fiber assembly', 'response to endoplasmic reticulum stress', 'T cell differentiation']
Copper transport protein ATOX1
12
Copper-transporting ATPase 1
19
4.0
48
0.52
O00244Q04656['cellular copper ion homeostasis', 'copper ion transport', 'response to oxidative stress']['blood vessel development', 'blood vessel remodeling', 'cartilage development', 'catecholamine metabolic process', 'cellular copper ion homeostasis', 'cellular response to amino acid stimulus', 'cellular response to antibiotic', 'cellular response to cadmium ion', 'cellular response to cobalt ion', 'cellular response to copper ion', 'cellular response to hypoxia', 'cellular response to iron ion', 'cellular response to lead ion', 'cellular response to platelet-derived growth factor stimulus', 'central nervous system neuron development', 'cerebellar Purkinje cell differentiation', 'collagen fibril organization', 'copper ion export', 'copper ion homeostasis', 'copper ion import', 'copper ion transport', 'detoxification of copper ion', 'dopamine metabolic process', 'elastic fiber assembly', 'elastin biosynthetic process', 'epinephrine metabolic process', 'extracellular matrix organization', 'female pregnancy', 'hair follicle morphogenesis', 'in utero embryonic development', 'lactation', 'liver development', 'locomotory behavior', 'lung alveolus development', 'mitochondrion organization', 'negative regulation of iron ion transmembrane transport', 'neuron projection morphogenesis', 'norepinephrine metabolic process', 'peptidyl-lysine modification', 'pigmentation', 'positive regulation of catalytic activity', 'positive regulation of cell size', 'positive regulation of epithelial cell proliferation', 'positive regulation of lamellipodium assembly', 'positive regulation of melanin biosynthetic process', 'positive regulation of response to wounding', 'positive regulation of tyrosinase activity', 'positive regulation of vascular associated smooth muscle cell migration', 'pyramidal neuron development', 'regulation of cytochrome-c oxidase activity', 'regulation of gene expression', 'regulation of oxidative phosphorylation', 'removal of superoxide radicals', 'response to iron(III) ion', 'response to manganese ion', 'response to zinc ion', 'serotonin metabolic process', 'skin development', 'T-helper cell differentiation', 'tryptophan metabolic process']
Xanthine dehydrogenase/oxidase
487
Xanthine dehydrogenase/oxidase
1317
4.0
74
0.34
P80457P80457['xanthine catabolic process']['xanthine catabolic process']
Histone acetyltransferase p300
1408
Histone acetyltransferase p300
1408
4.0
53
0.47
Q09472Q09472['animal organ morphogenesis', 'apoptotic process', 'B cell differentiation', 'behavioral defense response', 'cell cycle', 'cellular response to UV', 'circadian rhythm', 'epigenetic maintenance of chromatin in transcription-competent conformation', 'face morphogenesis', 'fat cell differentiation', 'heart development', 'histone acetylation', 'histone H2B acetylation', 'histone H3-K56 acetylation', 'histone H4 acetylation', 'internal peptidyl-lysine acetylation', 'internal protein amino acid acetylation', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'learning or memory', 'lung development', 'macrophage derived foam cell differentiation', 'megakaryocyte development', 'multicellular organism growth', 'N-terminal peptidyl-lysine acetylation', 'negative regulation of gluconeogenesis', 'negative regulation of protein-containing complex assembly', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'peptidyl-lysine acetylation', 'peptidyl-lysine butyrylation', 'peptidyl-lysine crotonylation', 'peptidyl-lysine propionylation', 'platelet formation', 'positive regulation by host of viral transcription', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of neuron projection development', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of protein binding', 'positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta receptor signaling pathway', 'protein acetylation', 'protein destabilization', 'protein stabilization', 'regulation of androgen receptor signaling pathway', 'regulation of autophagy', 'regulation of cellular response to heat', 'regulation of glycolytic process', 'regulation of mitochondrion organization', 'regulation of signal transduction by p53 class mediator', 'regulation of tubulin deacetylation', 'response to estrogen', 'response to hypoxia', 'skeletal muscle tissue development', 'somitogenesis', 'stimulatory C-type lectin receptor signaling pathway', 'swimming', 'thigmotaxis', 'transcription by RNA polymerase II']['animal organ morphogenesis', 'apoptotic process', 'B cell differentiation', 'behavioral defense response', 'cell cycle', 'cellular response to UV', 'circadian rhythm', 'epigenetic maintenance of chromatin in transcription-competent conformation', 'face morphogenesis', 'fat cell differentiation', 'heart development', 'histone acetylation', 'histone H2B acetylation', 'histone H3-K56 acetylation', 'histone H4 acetylation', 'internal peptidyl-lysine acetylation', 'internal protein amino acid acetylation', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'learning or memory', 'lung development', 'macrophage derived foam cell differentiation', 'megakaryocyte development', 'multicellular organism growth', 'N-terminal peptidyl-lysine acetylation', 'negative regulation of gluconeogenesis', 'negative regulation of protein-containing complex assembly', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'peptidyl-lysine acetylation', 'peptidyl-lysine butyrylation', 'peptidyl-lysine crotonylation', 'peptidyl-lysine propionylation', 'platelet formation', 'positive regulation by host of viral transcription', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of neuron projection development', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of protein binding', 'positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta receptor signaling pathway', 'protein acetylation', 'protein destabilization', 'protein stabilization', 'regulation of androgen receptor signaling pathway', 'regulation of autophagy', 'regulation of cellular response to heat', 'regulation of glycolytic process', 'regulation of mitochondrion organization', 'regulation of signal transduction by p53 class mediator', 'regulation of tubulin deacetylation', 'response to estrogen', 'response to hypoxia', 'skeletal muscle tissue development', 'somitogenesis', 'stimulatory C-type lectin receptor signaling pathway', 'swimming', 'thigmotaxis', 'transcription by RNA polymerase II']
Cytoglobin
38
Cytoglobin
38
4.0
89
0.28
Q8WWM9Q8WWM9['fatty acid oxidation', 'negative regulation of collagen biosynthetic process', 'negative regulation of fibroblast migration', 'negative regulation of hepatic stellate cell activation', 'oxygen transport', 'response to hypoxia', 'response to oxidative stress']['fatty acid oxidation', 'negative regulation of collagen biosynthetic process', 'negative regulation of fibroblast migration', 'negative regulation of hepatic stellate cell activation', 'oxygen transport', 'response to hypoxia', 'response to oxidative stress']
4-aminobutyrate aminotransferase, mitochondrial
166
4-aminobutyrate aminotransferase, mitochondrial
163
5.5
97
0.19
P80147P80147['behavioral response to cocaine', 'gamma-aminobutyric acid catabolic process', 'neurotransmitter catabolic process']['behavioral response to cocaine', 'gamma-aminobutyric acid catabolic process', 'neurotransmitter catabolic process']
Thioredoxin reductase 1, cytoplasmic
458
Thioredoxin reductase 1, cytoplasmic
458
5.5
68
0.27
O89049O89049['benzene-containing compound metabolic process', 'cell population proliferation', 'cell redox homeostasis', 'cellular response to copper ion', 'cellular response to hyperoxia', 'gastrulation', 'halogen metabolic process', 'hydrogen peroxide catabolic process', 'mesoderm formation', 'NADPH oxidation', 'placenta development', 'positive regulation of cell death', 'response to axon injury', 'response to hyperoxia', 'response to oxidative stress', 'response to selenium ion', 'response to xenobiotic stimulus', 'selenocysteine metabolic process']['benzene-containing compound metabolic process', 'cell population proliferation', 'cell redox homeostasis', 'cellular response to copper ion', 'cellular response to hyperoxia', 'gastrulation', 'halogen metabolic process', 'hydrogen peroxide catabolic process', 'mesoderm formation', 'NADPH oxidation', 'placenta development', 'positive regulation of cell death', 'response to axon injury', 'response to hyperoxia', 'response to oxidative stress', 'response to selenium ion', 'response to xenobiotic stimulus', 'selenocysteine metabolic process']
cGMP-dependent 3',5'-cyclic phosphodiesterase
393
cGMP-dependent 3',5'-cyclic phosphodiesterase
393
5.5
61
0.3
O00408O00408['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'aorta development', 'cAMP-mediated signaling', 'cellular response to 2,3,7,8-tetrachlorodibenzodioxine', 'cellular response to cAMP', 'cellular response to cGMP', 'cellular response to granulocyte macrophage colony-stimulating factor stimulus', 'cellular response to macrophage colony-stimulating factor stimulus', 'cellular response to mechanical stimulus', 'cellular response to transforming growth factor beta stimulus', 'cellular response to xenobiotic stimulus', 'cGMP catabolic process', 'cGMP-mediated signaling', 'establishment of endothelial barrier', 'heart valve development', 'monocyte differentiation', 'negative regulation of cAMP-mediated signaling', 'negative regulation of cGMP-mediated signaling', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of vascular permeability', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of vascular permeability', 'regulation of cAMP-mediated signaling', 'regulation of cGMP-mediated signaling', 'regulation of mitochondrion organization', 'signal transduction', 'ventricular septum development']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'aorta development', 'cAMP-mediated signaling', 'cellular response to 2,3,7,8-tetrachlorodibenzodioxine', 'cellular response to cAMP', 'cellular response to cGMP', 'cellular response to granulocyte macrophage colony-stimulating factor stimulus', 'cellular response to macrophage colony-stimulating factor stimulus', 'cellular response to mechanical stimulus', 'cellular response to transforming growth factor beta stimulus', 'cellular response to xenobiotic stimulus', 'cGMP catabolic process', 'cGMP-mediated signaling', 'establishment of endothelial barrier', 'heart valve development', 'monocyte differentiation', 'negative regulation of cAMP-mediated signaling', 'negative regulation of cGMP-mediated signaling', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of vascular permeability', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of vascular permeability', 'regulation of cAMP-mediated signaling', 'regulation of cGMP-mediated signaling', 'regulation of mitochondrion organization', 'signal transduction', 'ventricular septum development']
Dihydropyrimidine dehydrogenase [NADP(+)]
82
Dihydropyrimidine dehydrogenase [NADP(+)]
956
5.5
91
0.2
Q28943Q28943['beta-alanine biosynthetic process', 'thymidine catabolic process', 'thymine catabolic process', 'uracil catabolic process']['beta-alanine biosynthetic process', 'thymidine catabolic process', 'thymine catabolic process', 'uracil catabolic process']
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
112
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
112
5.5
65
0.28
Q9TTF5Q9TTF5['metabolic process']['metabolic process']
Granzyme H
170
Granzyme H
170
5.5
61
0.3
P20718P20718['apoptotic process', 'cytolysis', 'proteolysis']['apoptotic process', 'cytolysis', 'proteolysis']
Tropomyosin alpha-1 chain
190
Tropomyosin alpha-1 chain
190
5.5
53
0.34
1
✔P42639P42639['actin filament organization', 'cardiac muscle contraction', 'muscle contraction']['actin filament organization', 'cardiac muscle contraction', 'muscle contraction']
Probable tRNA(His) guanylyltransferase
51
Probable tRNA(His) guanylyltransferase
51
5.5
71
0.26
Q9NWX6Q9NWX6['mitochondrial fusion', 'protein homotetramerization', 'response to oxidative stress', 'stress-induced mitochondrial fusion', 'tRNA modification', 'tRNA processing']['mitochondrial fusion', 'protein homotetramerization', 'response to oxidative stress', 'stress-induced mitochondrial fusion', 'tRNA modification', 'tRNA processing']
Proline-serine-threonine phosphatase-interacting protein 1
242
Proline-serine-threonine phosphatase-interacting protein 1
242
5.5
75
0.24
O43586O43586['actin filament polymerization', 'cell adhesion', 'endocytosis', 'inflammatory response', 'innate immune response', 'signal transduction']['actin filament polymerization', 'cell adhesion', 'endocytosis', 'inflammatory response', 'innate immune response', 'signal transduction']
Integrator complex subunit 9
637
Integrator complex subunit 11
513
5.5
81
0.22
Q9NV88Q5TA45['regulation of transcription elongation from RNA polymerase II promoter', "snRNA 3'-end processing", 'snRNA processing']['regulation of transcription elongation from RNA polymerase II promoter', 'snRNA processing']
Mothers against decapentaplegic homolog 3
338
Zinc finger FYVE domain-containing protein 9
783
5.5
66
0.28
P84022O95405['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'activin receptor signaling pathway', 'adrenal gland development', 'anatomical structure morphogenesis', 'BMP signaling pathway', 'cell differentiation', 'cell-cell junction organization', 'cellular response to transforming growth factor beta stimulus', 'cellular response to virus', 'developmental growth', 'embryonic cranial skeleton morphogenesis', 'embryonic foregut morphogenesis', 'embryonic pattern specification', 'endoderm development', 'extrinsic apoptotic signaling pathway', 'heart looping', 'immune response', 'immune system development', 'in utero embryonic development', 'JNK cascade', 'lens fiber cell differentiation', 'liver development', 'mesoderm formation', 'negative regulation of apoptotic process', 'negative regulation of cardiac muscle hypertrophy in response to stress', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cytosolic calcium ion concentration', 'negative regulation of fat cell differentiation', 'negative regulation of inflammatory response', 'negative regulation of lung blood pressure', 'negative regulation of osteoblast differentiation', 'negative regulation of osteoblast proliferation', 'negative regulation of protein catabolic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of wound healing', 'nodal signaling pathway', 'osteoblast development', 'paraxial mesoderm morphogenesis', 'pericardium development', 'positive regulation of alkaline phosphatase activity', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cell migration', 'positive regulation of chondrocyte differentiation', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of extracellular matrix assembly', 'positive regulation of focal adhesion assembly', 'positive regulation of gene expression', 'positive regulation of interleukin-1 beta production', 'positive regulation of miRNA transcription', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of positive chemotaxis', 'positive regulation of protein import into nucleus', 'positive regulation of stress fiber assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta3 production', 'primary miRNA processing', 'protein stabilization', 'regulation of binding', 'regulation of epithelial cell proliferation', 'regulation of immune response', 'regulation of miRNA transcription', 'regulation of striated muscle tissue development', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'signal transduction involved in regulation of gene expression', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'somitogenesis', 'T cell activation', 'thyroid gland development', 'transdifferentiation', 'transforming growth factor beta receptor signaling pathway', 'ureteric bud development', 'wound healing']['endocytosis', 'endosomal transport', 'transforming growth factor beta receptor signaling pathway']
DNA repair protein RAD50
681
DNA repair protein RAD50
681
4.0
67
0.38
Q92878Q92878['cellular response to DNA damage stimulus', 'chromosome organization involved in meiotic cell cycle', 'DNA double-strand break processing', 'DNA duplex unwinding', 'DNA recombination', 'DNA repair', 'DNA strand resection involved in replication fork processing', 'double-strand break repair', 'homologous recombination', 'mitotic G2/M transition checkpoint', 'negative regulation of telomere capping', 'nucleic acid phosphodiester bond hydrolysis', 'positive regulation of kinase activity', 'positive regulation of protein autophosphorylation', 'positive regulation of telomere maintenance', 'reciprocal meiotic recombination', 'regulation of mitotic recombination', 'telomere maintenance', 'telomere maintenance via recombination', 'telomere maintenance via telomerase', "telomeric 3' overhang formation"]['cellular response to DNA damage stimulus', 'chromosome organization involved in meiotic cell cycle', 'DNA double-strand break processing', 'DNA duplex unwinding', 'DNA recombination', 'DNA repair', 'DNA strand resection involved in replication fork processing', 'double-strand break repair', 'homologous recombination', 'mitotic G2/M transition checkpoint', 'negative regulation of telomere capping', 'nucleic acid phosphodiester bond hydrolysis', 'positive regulation of kinase activity', 'positive regulation of protein autophosphorylation', 'positive regulation of telomere maintenance', 'reciprocal meiotic recombination', 'regulation of mitotic recombination', 'telomere maintenance', 'telomere maintenance via recombination', 'telomere maintenance via telomerase', "telomeric 3' overhang formation"]
C-C motif chemokine 14
35
C-C motif chemokine 14
35
3.8
78
0.34
Q16627Q16627['cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']['cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']
Beta-adrenergic receptor kinase 1
120
Beta-adrenergic receptor kinase 1
120
3.8
42
0.62
P21146P21146['cardiac muscle contraction', 'desensitization of G protein-coupled receptor signaling pathway', 'G protein-coupled acetylcholine receptor signaling pathway', 'G protein-coupled receptor internalization', 'G protein-coupled receptor signaling pathway', 'heart development', 'intracellular protein transport', 'negative regulation of relaxation of smooth muscle', 'negative regulation of striated muscle contraction', 'negative regulation of the force of heart contraction by chemical signal', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of protein localization to cilium', 'positive regulation of smoothened signaling pathway', 'protein phosphorylation', 'regulation of signal transduction', 'regulation of the force of heart contraction', 'tachykinin receptor signaling pathway', 'viral entry into host cell', 'viral genome replication']['cardiac muscle contraction', 'desensitization of G protein-coupled receptor signaling pathway', 'G protein-coupled acetylcholine receptor signaling pathway', 'G protein-coupled receptor internalization', 'G protein-coupled receptor signaling pathway', 'heart development', 'intracellular protein transport', 'negative regulation of relaxation of smooth muscle', 'negative regulation of striated muscle contraction', 'negative regulation of the force of heart contraction by chemical signal', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of protein localization to cilium', 'positive regulation of smoothened signaling pathway', 'protein phosphorylation', 'regulation of signal transduction', 'regulation of the force of heart contraction', 'tachykinin receptor signaling pathway', 'viral entry into host cell', 'viral genome replication']
Anaphase-promoting complex subunit 11
51
Anaphase-promoting complex subunit 11
76
3.8
37
0.7
Q9NYG5Q9NYG5['anaphase-promoting complex-dependent catabolic process', 'cell division', 'mitotic cell cycle', 'positive regulation of mitotic metaphase/anaphase transition', 'protein K11-linked ubiquitination', 'protein ubiquitination', 'regulation of meiotic cell cycle', 'regulation of mitotic cell cycle', 'ubiquitin-dependent protein catabolic process']['anaphase-promoting complex-dependent catabolic process', 'cell division', 'mitotic cell cycle', 'positive regulation of mitotic metaphase/anaphase transition', 'protein K11-linked ubiquitination', 'protein ubiquitination', 'regulation of meiotic cell cycle', 'regulation of mitotic cell cycle', 'ubiquitin-dependent protein catabolic process']
MORC family CW-type zinc finger protein 3
446
MORC family CW-type zinc finger protein 3
446
3.8
75
0.35
Q14149Q14149['innate immune response', 'maintenance of protein location in nucleus', 'negative regulation of fibroblast proliferation', 'peptidyl-serine phosphorylation', 'positive regulation of cellular senescence', 'post-embryonic development', 'protein phosphorylation', 'protein stabilization']['innate immune response', 'maintenance of protein location in nucleus', 'negative regulation of fibroblast proliferation', 'peptidyl-serine phosphorylation', 'positive regulation of cellular senescence', 'post-embryonic development', 'protein phosphorylation', 'protein stabilization']
Copper transport protein ATOX1
15
Copper transport protein ATOX1
15
3.8
82
0.32
O00244O00244['cellular copper ion homeostasis', 'copper ion transport', 'response to oxidative stress']['cellular copper ion homeostasis', 'copper ion transport', 'response to oxidative stress']
GA-binding protein alpha chain
421
GA-binding protein subunit beta-1
137
4.0
51
0.49
Q00422Q00420['blastocyst formation', 'cell differentiation', 'cellular response to dopamine', 'in utero embryonic development', 'negative regulation of megakaryocyte differentiation', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of gene expression', 'positive regulation of transcription by RNA polymerase II', 'regulation of transcription by RNA polymerase II']['mitochondrion organization', 'positive regulation of transcription by RNA polymerase II']
Nucleoside diphosphate kinase A 1
145
Nucleoside diphosphate kinase A 1
145
4.8
60
0.35
P52174P52174['cell differentiation', 'CTP biosynthetic process', 'endocytosis', 'GTP biosynthetic process', 'nervous system development', 'nucleoside diphosphate phosphorylation', 'UTP biosynthetic process']['cell differentiation', 'CTP biosynthetic process', 'endocytosis', 'GTP biosynthetic process', 'nervous system development', 'nucleoside diphosphate phosphorylation', 'UTP biosynthetic process']
E3 ubiquitin-protein ligase MYLIP
400
E3 ubiquitin-protein ligase MYLIP
400
5.7
68
0.26
Q8WY64Q8WY64['cholesterol homeostasis', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of neuron projection development', 'nervous system development', 'positive regulation of protein catabolic process', 'protein destabilization', 'protein ubiquitination', 'regulation of low-density lipoprotein particle receptor catabolic process', 'ubiquitin-dependent protein catabolic process']['cholesterol homeostasis', 'negative regulation of low-density lipoprotein particle clearance', 'negative regulation of neuron projection development', 'nervous system development', 'positive regulation of protein catabolic process', 'protein destabilization', 'protein ubiquitination', 'regulation of low-density lipoprotein particle receptor catabolic process', 'ubiquitin-dependent protein catabolic process']
NAD(+) hydrolase SARM1
649
NAD(+) hydrolase SARM1
649
5.7
76
0.23
Q6SZW1Q6SZW1['cell differentiation', 'innate immune response', 'NAD catabolic process', 'negative regulation of MyD88-independent toll-like receptor signaling pathway', 'nervous system development', 'positive regulation of neuron death', 'regulation of dendrite morphogenesis', 'regulation of neuron apoptotic process', 'regulation of neuron death', 'response to axon injury', 'response to glucose', 'signal transduction']['cell differentiation', 'innate immune response', 'NAD catabolic process', 'negative regulation of MyD88-independent toll-like receptor signaling pathway', 'nervous system development', 'positive regulation of neuron death', 'regulation of dendrite morphogenesis', 'regulation of neuron apoptotic process', 'regulation of neuron death', 'response to axon injury', 'response to glucose', 'signal transduction']
Killer cell lectin-like receptor 3
149
Killer cell lectin-like receptor 3
149
5.2
71
0.27
Q61198Q61198['cell adhesion']['cell adhesion']
SH3 domain-containing protein
246
SH3 domain-containing protein
246
5.2
92
0.21
Q8BX41Q8BX41[][]
Nucleoside diphosphate kinase B
145
Nucleoside diphosphate kinase B
145
4.8
58
0.36
P22392P22392['cell adhesion', 'CTP biosynthetic process', 'GTP biosynthetic process', 'integrin-mediated signaling pathway', 'negative regulation of apoptotic process', 'nucleoside diphosphate phosphorylation', 'nucleoside triphosphate biosynthetic process', 'positive regulation of epithelial cell proliferation', 'positive regulation of keratinocyte differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of apoptotic process', 'regulation of epidermis development', 'UTP biosynthetic process']['cell adhesion', 'CTP biosynthetic process', 'GTP biosynthetic process', 'integrin-mediated signaling pathway', 'negative regulation of apoptotic process', 'nucleoside diphosphate phosphorylation', 'nucleoside triphosphate biosynthetic process', 'positive regulation of epithelial cell proliferation', 'positive regulation of keratinocyte differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of apoptotic process', 'regulation of epidermis development', 'UTP biosynthetic process']
Norrin
95
Norrin
95
4.8
84
0.25
Q00604Q00604['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']['decidualization', 'extracellular matrix-cell signaling', 'nervous system development', 'Norrin signaling pathway', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription, DNA-templated', 'retina vasculature morphogenesis in camera-type eye', 'vacuole organization', 'visual perception', 'Wnt signaling pathway']
Cysteine desulfurase, mitochondrial
381
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
69
4.8
75
0.28
Q9Y697Q9H1K1['[2Fe-2S] cluster assembly', 'iron incorporation into metallo-sulfur cluster', 'iron-sulfur cluster assembly', 'Mo-molybdopterin cofactor biosynthetic process']['cellular iron ion homeostasis', 'iron-sulfur cluster assembly', 'negative regulation of iron ion import across plasma membrane', 'positive regulation of aconitate hydratase activity', 'positive regulation of mitochondrial electron transport, NADH to ubiquinone']
LINE-1 retrotransposable element ORF1 protein
76
LINE-1 retrotransposable element ORF1 protein
76
4.8
67
0.31
Q9UN81Q9UN81['transposition, RNA-mediated']['transposition, RNA-mediated']
Tripartite motif-containing 25 variant
365
Tripartite motif-containing 25 variant
365
5.7
56
0.31
Q59GW5Q59GW5[][]
Protein PML
72
Protein PML
91
5.7
66
0.27
P29590P29590['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'apoptotic process', 'branching involved in mammary gland duct morphogenesis', 'cell fate commitment', 'cellular response to interleukin-4', 'cellular response to leukemia inhibitory factor', 'cellular senescence', 'circadian regulation of gene expression', 'common-partner SMAD protein phosphorylation', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'endoplasmic reticulum calcium ion homeostasis', 'entrainment of circadian clock by photoperiod', 'extrinsic apoptotic signaling pathway', 'fibroblast migration', 'innate immune response', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'intrinsic apoptotic signaling pathway in response to oxidative stress', 'maintenance of protein location in nucleus', 'myeloid cell differentiation', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of interleukin-1 beta production', 'negative regulation of mitotic cell cycle', 'negative regulation of telomerase activity', 'negative regulation of telomere maintenance via telomerase', 'negative regulation of transcription, DNA-templated', 'negative regulation of translation in response to oxidative stress', 'negative regulation of ubiquitin-dependent protein catabolic process', 'oncogene-induced cell senescence', 'PML body organization', 'positive regulation of apoptotic process involved in mammary gland involution', 'positive regulation of defense response to virus by host', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of fibroblast proliferation', 'positive regulation of histone deacetylation', 'positive regulation of peptidyl-lysine acetylation', 'positive regulation of protein localization to chromosome, telomeric region', 'positive regulation of signal transduction by p53 class mediator', 'positive regulation of telomere maintenance', 'positive regulation of transcription, DNA-templated', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein import into nucleus', 'protein stabilization', 'protein targeting', 'protein-containing complex assembly', 'protein-containing complex localization', 'regulation of calcium ion transport into cytosol', 'regulation of cell adhesion', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of double-strand break repair', 'regulation of transcription, DNA-templated', 'response to cytokine', 'response to gamma radiation', 'response to hypoxia', 'response to UV', 'retinoic acid receptor signaling pathway', 'suppression of viral release by host', 'transforming growth factor beta receptor signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'apoptotic process', 'branching involved in mammary gland duct morphogenesis', 'cell fate commitment', 'cellular response to interleukin-4', 'cellular response to leukemia inhibitory factor', 'cellular senescence', 'circadian regulation of gene expression', 'common-partner SMAD protein phosphorylation', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'endoplasmic reticulum calcium ion homeostasis', 'entrainment of circadian clock by photoperiod', 'extrinsic apoptotic signaling pathway', 'fibroblast migration', 'innate immune response', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'intrinsic apoptotic signaling pathway in response to oxidative stress', 'maintenance of protein location in nucleus', 'myeloid cell differentiation', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of interleukin-1 beta production', 'negative regulation of mitotic cell cycle', 'negative regulation of telomerase activity', 'negative regulation of telomere maintenance via telomerase', 'negative regulation of transcription, DNA-templated', 'negative regulation of translation in response to oxidative stress', 'negative regulation of ubiquitin-dependent protein catabolic process', 'oncogene-induced cell senescence', 'PML body organization', 'positive regulation of apoptotic process involved in mammary gland involution', 'positive regulation of defense response to virus by host', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of fibroblast proliferation', 'positive regulation of histone deacetylation', 'positive regulation of peptidyl-lysine acetylation', 'positive regulation of protein localization to chromosome, telomeric region', 'positive regulation of signal transduction by p53 class mediator', 'positive regulation of telomere maintenance', 'positive regulation of transcription, DNA-templated', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein import into nucleus', 'protein stabilization', 'protein targeting', 'protein-containing complex assembly', 'protein-containing complex localization', 'regulation of calcium ion transport into cytosol', 'regulation of cell adhesion', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of double-strand break repair', 'regulation of transcription, DNA-templated', 'response to cytokine', 'response to gamma radiation', 'response to hypoxia', 'response to UV', 'retinoic acid receptor signaling pathway', 'suppression of viral release by host', 'transforming growth factor beta receptor signaling pathway']
Synaptic vesicle membrane protein VAT-1 homolog
324
Synaptic vesicle membrane protein VAT-1 homolog
324
5.7
109
0.16
Q99536Q99536['negative regulation of mitochondrial fusion']['negative regulation of mitochondrial fusion']
E3 ubiquitin-protein ligase Mdm2
449
E3 ubiquitin-protein ligase Mdm2
449
5.7
100
0.17
Q7YRZ8Q7YRZ8['apoptotic process', 'negative regulation of apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'protein ubiquitination', 'regulation of biological quality', 'regulation of cell cycle', 'regulation of transcription by RNA polymerase II']['apoptotic process', 'negative regulation of apoptotic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'protein ubiquitination', 'regulation of biological quality', 'regulation of cell cycle', 'regulation of transcription by RNA polymerase II']
L-lactate dehydrogenase C chain
21
L-lactate dehydrogenase C chain
21
5.7
68
0.26
P00342P00342['ATP biosynthetic process', 'flagellated sperm motility', 'lactate biosynthetic process from pyruvate', 'lactate oxidation', 'pyruvate metabolic process']['ATP biosynthetic process', 'flagellated sperm motility', 'lactate biosynthetic process from pyruvate', 'lactate oxidation', 'pyruvate metabolic process']
MHC class I recognition receptor Ly49I
149
MHC class I recognition receptor Ly49I
154
5.7
74
0.24
Q9JHN9Q9JHN9[][]
Nucleoside diphosphate kinase A
145
Nucleoside diphosphate kinase A
145
4.8
58
0.36
P15531P15531['cell differentiation', 'CTP biosynthetic process', 'endocytosis', 'GTP biosynthetic process', 'lactation', 'negative regulation of cell population proliferation', 'nervous system development', 'nucleoside diphosphate phosphorylation', 'positive regulation of DNA binding', 'positive regulation of epithelial cell proliferation', 'regulation of apoptotic process', 'UTP biosynthetic process']['cell differentiation', 'CTP biosynthetic process', 'endocytosis', 'GTP biosynthetic process', 'lactation', 'negative regulation of cell population proliferation', 'nervous system development', 'nucleoside diphosphate phosphorylation', 'positive regulation of DNA binding', 'positive regulation of epithelial cell proliferation', 'regulation of apoptotic process', 'UTP biosynthetic process']
RecQ-like DNA helicase BLM
380
RecQ-like DNA helicase BLM
380
4.9
75
0.27
P54132P54132['cellular response to camptothecin', 'cellular response to DNA damage stimulus', 'cellular response to hydroxyurea', 'cellular response to ionizing radiation', 'DNA double-strand break processing', 'DNA duplex unwinding', 'DNA recombination', 'DNA repair', 'DNA replication', 'DNA unwinding involved in DNA replication', 'double-strand break repair via homologous recombination', 'G-quadruplex DNA unwinding', 'mitotic G2 DNA damage checkpoint signaling', 'negative regulation of cell division', 'negative regulation of DNA recombination', 'positive regulation of transcription, DNA-templated', 'protein complex oligomerization', 'protein homooligomerization', 'regulation of cyclin-dependent protein serine/threonine kinase activity', 'regulation of DNA-templated DNA replication', 'replication fork processing', 'replication fork protection', 'resolution of recombination intermediates', 'response to X-ray', 't-circle formation', 'telomere maintenance', 'telomere maintenance via semi-conservative replication', 'telomeric D-loop disassembly']['cellular response to camptothecin', 'cellular response to DNA damage stimulus', 'cellular response to hydroxyurea', 'cellular response to ionizing radiation', 'DNA double-strand break processing', 'DNA duplex unwinding', 'DNA recombination', 'DNA repair', 'DNA replication', 'DNA unwinding involved in DNA replication', 'double-strand break repair via homologous recombination', 'G-quadruplex DNA unwinding', 'mitotic G2 DNA damage checkpoint signaling', 'negative regulation of cell division', 'negative regulation of DNA recombination', 'positive regulation of transcription, DNA-templated', 'protein complex oligomerization', 'protein homooligomerization', 'regulation of cyclin-dependent protein serine/threonine kinase activity', 'regulation of DNA-templated DNA replication', 'replication fork processing', 'replication fork protection', 'resolution of recombination intermediates', 'response to X-ray', 't-circle formation', 'telomere maintenance', 'telomere maintenance via semi-conservative replication', 'telomeric D-loop disassembly']
Inositol-trisphosphate 3-kinase A
342
Inositol-trisphosphate 3-kinase A
342
4.7
60
0.35
P23677P23677['actin cytoskeleton organization', 'cellular response to calcium ion', 'dendritic spine maintenance', 'inositol metabolic process', 'inositol phosphate biosynthetic process', 'phosphatidylinositol phosphate biosynthetic process', 'phosphorylation', 'positive regulation of dendritic spine morphogenesis', 'regulation of synaptic plasticity', 'response to calcium ion', 'signal transduction']['actin cytoskeleton organization', 'cellular response to calcium ion', 'dendritic spine maintenance', 'inositol metabolic process', 'inositol phosphate biosynthetic process', 'phosphatidylinositol phosphate biosynthetic process', 'phosphorylation', 'positive regulation of dendritic spine morphogenesis', 'regulation of synaptic plasticity', 'response to calcium ion', 'signal transduction']
Isoaspartyl peptidase/L-asparaginase
202
Isoaspartyl peptidase/L-asparaginase
202
4.7
114
0.19
Q7L266Q7L266['asparagine catabolic process via L-aspartate', 'proteolysis']['asparagine catabolic process via L-aspartate', 'proteolysis']
Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
22
Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
22
4.7
56
0.38
Q9NUI1Q9NUI1['fatty acid beta-oxidation using acyl-CoA oxidase', 'fatty acid metabolic process', 'unsaturated fatty acid biosynthetic process']['fatty acid beta-oxidation using acyl-CoA oxidase', 'fatty acid metabolic process', 'unsaturated fatty acid biosynthetic process']
ATP-dependent RNA helicase DHX8
651
ATP-dependent RNA helicase DHX8
651
4.9
78
0.26
Q14562Q14562['mRNA splicing, via spliceosome', 'RNA processing', 'RNA splicing', 'spliceosomal complex disassembly']['mRNA splicing, via spliceosome', 'RNA processing', 'RNA splicing', 'spliceosomal complex disassembly']
E3 ubiquitin-protein ligase RNF31
893
E3 ubiquitin-protein ligase RNF31
885
4.9
64
0.32
Q96EP0Q96EP0['CD40 signaling pathway', 'defense response to bacterium', 'negative regulation of necroptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of xenophagy', 'protein linear polyubiquitination', 'protein polyubiquitination', 'T cell receptor signaling pathway']['CD40 signaling pathway', 'defense response to bacterium', 'negative regulation of necroptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of xenophagy', 'protein linear polyubiquitination', 'protein polyubiquitination', 'T cell receptor signaling pathway']
Syntenin-1
120
Syntenin-1
120
4.9
70
0.29
Q9JI92Q9JI92['actin cytoskeleton organization', 'chemical synaptic transmission', 'negative regulation of proteasomal ubiquitin-dependent protein catabolic process', 'negative regulation of receptor internalization', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of exosomal secretion', 'positive regulation of extracellular exosome assembly', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of transforming growth factor beta receptor signaling pathway', 'presynapse assembly', 'Ras protein signal transduction', 'regulation of mitotic cell cycle']['actin cytoskeleton organization', 'chemical synaptic transmission', 'negative regulation of proteasomal ubiquitin-dependent protein catabolic process', 'negative regulation of receptor internalization', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of exosomal secretion', 'positive regulation of extracellular exosome assembly', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of transforming growth factor beta receptor signaling pathway', 'presynapse assembly', 'Ras protein signal transduction', 'regulation of mitotic cell cycle']
Copper transport protein ATOX1
12
Copper-transporting ATPase 1
22
4.9
65
0.32
O00244Q04656['cellular copper ion homeostasis', 'copper ion transport', 'response to oxidative stress']['blood vessel development', 'blood vessel remodeling', 'cartilage development', 'catecholamine metabolic process', 'cellular copper ion homeostasis', 'cellular response to amino acid stimulus', 'cellular response to antibiotic', 'cellular response to cadmium ion', 'cellular response to cobalt ion', 'cellular response to copper ion', 'cellular response to hypoxia', 'cellular response to iron ion', 'cellular response to lead ion', 'cellular response to platelet-derived growth factor stimulus', 'central nervous system neuron development', 'cerebellar Purkinje cell differentiation', 'collagen fibril organization', 'copper ion export', 'copper ion homeostasis', 'copper ion import', 'copper ion transport', 'detoxification of copper ion', 'dopamine metabolic process', 'elastic fiber assembly', 'elastin biosynthetic process', 'epinephrine metabolic process', 'extracellular matrix organization', 'female pregnancy', 'hair follicle morphogenesis', 'in utero embryonic development', 'lactation', 'liver development', 'locomotory behavior', 'lung alveolus development', 'mitochondrion organization', 'negative regulation of iron ion transmembrane transport', 'neuron projection morphogenesis', 'norepinephrine metabolic process', 'peptidyl-lysine modification', 'pigmentation', 'positive regulation of catalytic activity', 'positive regulation of cell size', 'positive regulation of epithelial cell proliferation', 'positive regulation of lamellipodium assembly', 'positive regulation of melanin biosynthetic process', 'positive regulation of response to wounding', 'positive regulation of tyrosinase activity', 'positive regulation of vascular associated smooth muscle cell migration', 'pyramidal neuron development', 'regulation of cytochrome-c oxidase activity', 'regulation of gene expression', 'regulation of oxidative phosphorylation', 'removal of superoxide radicals', 'response to iron(III) ion', 'response to manganese ion', 'response to zinc ion', 'serotonin metabolic process', 'skin development', 'T-helper cell differentiation', 'tryptophan metabolic process']
Laforin
250
Laforin
250
4.9
79
0.26
O95278O95278['autophagosome assembly', 'calcium ion transport', 'carbohydrate phosphorylation', 'dephosphorylation', 'glial cell proliferation', 'glycogen biosynthetic process', 'glycogen metabolic process', 'habituation', 'L-glutamate transmembrane transport', 'mitochondrion organization', 'negative regulation of cell cycle', 'negative regulation of dephosphorylation', 'negative regulation of gene expression', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of phosphatase activity', 'peptidyl-tyrosine dephosphorylation', 'phosphorylated carbohydrate dephosphorylation', 'positive regulation of macroautophagy', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein dephosphorylation', 'regulation of cell growth', 'regulation of glycogen (starch) synthase activity', 'regulation of proteasomal protein catabolic process', 'regulation of protein import into nucleus', 'regulation of protein kinase activity', 'regulation of protein localization to plasma membrane', 'regulation of protein ubiquitination', 'regulation of ubiquitin protein ligase activity', 'Wnt signaling pathway']['autophagosome assembly', 'calcium ion transport', 'carbohydrate phosphorylation', 'dephosphorylation', 'glial cell proliferation', 'glycogen biosynthetic process', 'glycogen metabolic process', 'habituation', 'L-glutamate transmembrane transport', 'mitochondrion organization', 'negative regulation of cell cycle', 'negative regulation of dephosphorylation', 'negative regulation of gene expression', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of phosphatase activity', 'peptidyl-tyrosine dephosphorylation', 'phosphorylated carbohydrate dephosphorylation', 'positive regulation of macroautophagy', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein dephosphorylation', 'regulation of cell growth', 'regulation of glycogen (starch) synthase activity', 'regulation of proteasomal protein catabolic process', 'regulation of protein import into nucleus', 'regulation of protein kinase activity', 'regulation of protein localization to plasma membrane', 'regulation of protein ubiquitination', 'regulation of ubiquitin protein ligase activity', 'Wnt signaling pathway']
Vesicle-associated membrane protein 2
103
Syntaxin-1A
271
4.8
49
0.42
P63045P32851['calcium-ion regulated exocytosis', 'cellular response to insulin stimulus', 'eosinophil degranulation', 'exocytic insertion of neurotransmitter receptor to postsynaptic membrane', 'Golgi to plasma membrane protein transport', 'hormone secretion', 'long-term synaptic potentiation', 'membrane fusion', 'positive regulation of intracellular protein transport', 'protein transport', 'protein-containing complex assembly', 'regulated exocytosis', 'regulation of delayed rectifier potassium channel activity', 'regulation of exocytosis', 'regulation of synaptic vesicle recycling', 'regulation of vesicle-mediated transport', 'response to glucose', 'SNARE complex assembly', 'synaptic vesicle docking', 'synaptic vesicle endocytosis', 'synaptic vesicle exocytosis', 'vesicle fusion', 'vesicle-mediated transport']['calcium-ion regulated exocytosis', 'exocytosis', 'hormone secretion', 'insulin secretion', 'intracellular protein transport', 'modulation of excitatory postsynaptic potential', 'neurotransmitter transport', 'positive regulation of calcium ion-dependent exocytosis', 'positive regulation of catecholamine secretion', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of exocytosis', 'positive regulation of neurotransmitter secretion', 'positive regulation of norepinephrine secretion', 'protein localization to membrane', 'protein sumoylation', 'regulated exocytosis', 'regulation of exocytosis', 'regulation of synaptic vesicle priming', 'response to gravity', 'secretion by cell', 'SNARE complex assembly', 'synaptic vesicle docking', 'synaptic vesicle endocytosis', 'synaptic vesicle exocytosis', 'synaptic vesicle fusion to presynaptic active zone membrane', 'vesicle docking', 'vesicle fusion']
MHC class I recognition receptor Ly49I
154
MHC class I recognition receptor Ly49I
154
5.7
78
0.22
Q9JHN9Q9JHN9[][]
Pygopus homolog 1
371
Pygopus homolog 1
371
5.6
71
0.25
Q9Y3Y4Q9Y3Y4['canonical Wnt signaling pathway', 'hematopoietic progenitor cell differentiation', 'kidney development', 'positive regulation of transcription by RNA polymerase II', 'protein localization to nucleus', 'spermatid nucleus differentiation']['canonical Wnt signaling pathway', 'hematopoietic progenitor cell differentiation', 'kidney development', 'positive regulation of transcription by RNA polymerase II', 'protein localization to nucleus', 'spermatid nucleus differentiation']
Toll-like receptor 13
527
Toll-like receptor 13
527
5.6
77
0.23
Q6R5N8Q6R5N8['inflammatory response', 'innate immune response', 'MyD88-dependent toll-like receptor signaling pathway', 'regulation of MAPK cascade', 'response to virus', 'toll-like receptor 13 signaling pathway', 'toll-like receptor signaling pathway']['inflammatory response', 'innate immune response', 'MyD88-dependent toll-like receptor signaling pathway', 'regulation of MAPK cascade', 'response to virus', 'toll-like receptor 13 signaling pathway', 'toll-like receptor signaling pathway']
Killer cell lectin-like receptor 3
154
Killer cell lectin-like receptor 3
154
5.6
81
0.22
Q64329Q64329['cell adhesion']['cell adhesion']
C-C motif chemokine 1
33
C-C motif chemokine 1
57
5.7
60
0.29
P22362P22362['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of inflammatory response', 'positive regulation of interleukin-17 production', 'positive regulation of monocyte chemotaxis', 'signal transduction', 'viral process']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of inflammatory response', 'positive regulation of interleukin-17 production', 'positive regulation of monocyte chemotaxis', 'signal transduction', 'viral process']
Talin rod domain-containing protein 1
220
Talin rod domain-containing protein 1
220
5.7
88
0.2
Q9H1K6Q9H1K6[][]
E3 ubiquitin-protein ligase Mdm2
449
E3 ubiquitin-protein ligase Mdm2
449
5.6
101
0.18
Q00987Q00987['amyloid fibril formation', 'apoptotic process', 'atrial septum development', 'atrioventricular valve morphogenesis', 'blood vessel development', 'blood vessel remodeling', 'cardiac septum morphogenesis', 'cellular response to actinomycin D', 'cellular response to gamma radiation', 'cellular response to hypoxia', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'endocardial cushion morphogenesis', 'establishment of protein localization', 'negative regulation of DNA damage response, signal transduction by p53 class mediator', 'negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'negative regulation of signal transduction by p53 class mediator', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of cell population proliferation', 'positive regulation of mitotic cell cycle', 'positive regulation of muscle cell differentiation', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein autoubiquitination', 'protein destabilization', 'protein localization to nucleus', 'protein polyubiquitination', 'protein ubiquitination', 'protein-containing complex assembly', 'proteolysis involved in protein catabolic process', 'regulation of cell cycle', 'regulation of heart rate', 'regulation of protein catabolic process', 'regulation of transcription by RNA polymerase II', 'response to antibiotic', 'transcription factor catabolic process', 'traversing start control point of mitotic cell cycle', 'ubiquitin-dependent protein catabolic process', 'ventricular septum development']['amyloid fibril formation', 'apoptotic process', 'atrial septum development', 'atrioventricular valve morphogenesis', 'blood vessel development', 'blood vessel remodeling', 'cardiac septum morphogenesis', 'cellular response to actinomycin D', 'cellular response to gamma radiation', 'cellular response to hypoxia', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'endocardial cushion morphogenesis', 'establishment of protein localization', 'negative regulation of DNA damage response, signal transduction by p53 class mediator', 'negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'negative regulation of signal transduction by p53 class mediator', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of cell population proliferation', 'positive regulation of mitotic cell cycle', 'positive regulation of muscle cell differentiation', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein autoubiquitination', 'protein destabilization', 'protein localization to nucleus', 'protein polyubiquitination', 'protein ubiquitination', 'protein-containing complex assembly', 'proteolysis involved in protein catabolic process', 'regulation of cell cycle', 'regulation of heart rate', 'regulation of protein catabolic process', 'regulation of transcription by RNA polymerase II', 'response to antibiotic', 'transcription factor catabolic process', 'traversing start control point of mitotic cell cycle', 'ubiquitin-dependent protein catabolic process', 'ventricular septum development']
Lectin-related NK cell receptor LY49L4
148
Lectin-related NK cell receptor LY49L4
148
5.8
58
0.3
Q9JIP9Q9JIP9[][]
Mineralocorticoid receptor
645
Mineralocorticoid receptor
645
5.8
67
0.26
P08235P08235['intracellular steroid hormone receptor signaling pathway', 'positive regulation of NIK/NF-kappaB signaling', 'regulation of transcription by RNA polymerase II', 'signal transduction']['intracellular steroid hormone receptor signaling pathway', 'positive regulation of NIK/NF-kappaB signaling', 'regulation of transcription by RNA polymerase II', 'signal transduction']
MHC class I recognition receptor Ly49I
149
MHC class I recognition receptor Ly49I
149
5.8
71
0.24
Q9JHN9Q9JHN9[][]
Insulin-like growth factor I
96
Insulin-like growth factor-binding protein 1
206
5.6
77
0.23
P05019P08833['activation of protein kinase B activity', 'bone mineralization involved in bone maturation', 'cell activation', 'cell population proliferation', 'cellular response to amyloid-beta', 'ERK1 and ERK2 cascade', 'glycolate metabolic process', 'insulin-like growth factor receptor signaling pathway', 'muscle hypertrophy', 'muscle organ development', 'myoblast differentiation', 'myoblast proliferation', 'myotube cell development', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of gene expression', 'negative regulation of interleukin-1 beta production', 'negative regulation of neuroinflammatory response', 'negative regulation of oocyte development', 'negative regulation of release of cytochrome c from mitochondria', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of tumor necrosis factor production', 'negative regulation of vascular associated smooth muscle cell apoptotic process', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol-mediated signaling', 'positive regulation of activated T cell proliferation', 'positive regulation of calcineurin-NFAT signaling cascade', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of DNA binding', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Ras protein signal transduction', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of trophectodermal cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase B signaling', 'protein stabilization', 'proteoglycan biosynthetic process', 'Ras protein signal transduction', 'regulation of gene expression', 'regulation of multicellular organism growth', 'regulation of protein phosphorylation', 'response to heat', 'signal transduction', 'skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration', 'skeletal system development', 'wound healing']['aging', 'insulin receptor signaling pathway', 'negative regulation of canonical Wnt signaling pathway', 'positive regulation of cell growth', 'regulation of insulin-like growth factor receptor signaling pathway', 'signal transduction', 'tissue regeneration']
Brain-specific angiogenesis inhibitor 1-associated protein 2
230
Brain-specific angiogenesis inhibitor 1-associated protein 2
195
5.8
70
0.25
Q9UQB8Q9UQB8['actin crosslink formation', 'actin filament bundle assembly', 'axonogenesis', 'brain development', 'cellular response to epidermal growth factor stimulus', 'cellular response to L-glutamate', 'dendrite development', 'insulin receptor signaling pathway', 'modification of synaptic structure, modulating synaptic transmission', 'plasma membrane organization', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of actin filament polymerization', 'positive regulation of dendritic spine morphogenesis', 'positive regulation of excitatory postsynaptic potential', 'protein localization to synapse', 'regulation of actin cytoskeleton organization', 'regulation of cell shape', 'regulation of modification of postsynaptic actin cytoskeleton', 'regulation of synaptic plasticity', 'response to bacterium']['actin crosslink formation', 'actin filament bundle assembly', 'axonogenesis', 'brain development', 'cellular response to epidermal growth factor stimulus', 'cellular response to L-glutamate', 'dendrite development', 'insulin receptor signaling pathway', 'modification of synaptic structure, modulating synaptic transmission', 'plasma membrane organization', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of actin filament polymerization', 'positive regulation of dendritic spine morphogenesis', 'positive regulation of excitatory postsynaptic potential', 'protein localization to synapse', 'regulation of actin cytoskeleton organization', 'regulation of cell shape', 'regulation of modification of postsynaptic actin cytoskeleton', 'regulation of synaptic plasticity', 'response to bacterium']
Uromodulin
335
Uromodulin
335
4.8
82
0.26
P07911P07911['apoptotic signaling pathway', 'autophagy', 'cellular calcium ion homeostasis', 'cellular chloride ion homeostasis', 'cellular defense response', 'cellular phosphate ion homeostasis', 'cellular response to unfolded protein', 'cellular sodium ion homeostasis', 'chaperone-mediated protein folding', 'citric acid secretion', 'collecting duct development', 'connective tissue replacement', 'creatinine homeostasis', 'defense response to Gram-negative bacterium', 'endoplasmic reticulum organization', 'glomerular filtration', 'heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules', 'inflammatory response', 'juxtaglomerular apparatus development', 'leukocyte cell-cell adhesion', 'lipid metabolic process', 'metanephric ascending thin limb development', 'metanephric distal convoluted tubule development', 'metanephric thick ascending limb development', 'micturition', 'multicellular organismal response to stress', 'negative regulation of cell population proliferation', 'neutrophil migration', 'organ or tissue specific immune response', 'peptidyl-threonine phosphorylation', 'potassium ion homeostasis', 'protein localization to vacuole', 'protein transport into plasma membrane raft', 'regulation of blood pressure', 'regulation of protein transport', 'regulation of urine volume', 'renal sodium ion absorption', 'renal urate salt excretion', 'renal water homeostasis', 'response to lipopolysaccharide', 'response to water deprivation', 'response to xenobiotic stimulus', 'RNA splicing', 'tumor necrosis factor-mediated signaling pathway', 'ubiquitin-dependent ERAD pathway', 'urate transport', 'urea transmembrane transport']['apoptotic signaling pathway', 'autophagy', 'cellular calcium ion homeostasis', 'cellular chloride ion homeostasis', 'cellular defense response', 'cellular phosphate ion homeostasis', 'cellular response to unfolded protein', 'cellular sodium ion homeostasis', 'chaperone-mediated protein folding', 'citric acid secretion', 'collecting duct development', 'connective tissue replacement', 'creatinine homeostasis', 'defense response to Gram-negative bacterium', 'endoplasmic reticulum organization', 'glomerular filtration', 'heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules', 'inflammatory response', 'juxtaglomerular apparatus development', 'leukocyte cell-cell adhesion', 'lipid metabolic process', 'metanephric ascending thin limb development', 'metanephric distal convoluted tubule development', 'metanephric thick ascending limb development', 'micturition', 'multicellular organismal response to stress', 'negative regulation of cell population proliferation', 'neutrophil migration', 'organ or tissue specific immune response', 'peptidyl-threonine phosphorylation', 'potassium ion homeostasis', 'protein localization to vacuole', 'protein transport into plasma membrane raft', 'regulation of blood pressure', 'regulation of protein transport', 'regulation of urine volume', 'renal sodium ion absorption', 'renal urate salt excretion', 'renal water homeostasis', 'response to lipopolysaccharide', 'response to water deprivation', 'response to xenobiotic stimulus', 'RNA splicing', 'tumor necrosis factor-mediated signaling pathway', 'ubiquitin-dependent ERAD pathway', 'urate transport', 'urea transmembrane transport']
Heat shock cognate 71 kDa protein
603
Heat shock cognate 71 kDa protein
574
4.9
63
0.32
P63018P63018['aging', 'ATP metabolic process', 'axo-dendritic transport', 'cellular response to cadmium ion', 'cellular response to heat', 'cellular response to unfolded protein', 'cerebellum development', 'chaperone cofactor-dependent protein refolding', 'chaperone-mediated autophagy', 'chaperone-mediated autophagy translocation complex disassembly', 'chaperone-mediated protein folding', 'clathrin coat disassembly', 'estrous cycle', 'forebrain development', 'G1/S transition of mitotic cell cycle', 'kidney development', 'late endosomal microautophagy', 'maintenance of postsynaptic specialization structure', 'modulation by host of viral process', 'mRNA processing', 'negative regulation of cardiac muscle cell apoptotic process', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of supramolecular fiber organization', 'negative regulation of transcription, DNA-templated', 'positive regulation by host of viral genome replication', 'positive regulation of catalytic activity', 'positive regulation of gene expression', 'positive regulation of lysosomal membrane permeability', 'positive regulation of mRNA splicing, via spliceosome', 'positive regulation of phagocytosis', 'positive regulation of protein refolding', 'positive regulation of proteolysis', 'positive regulation of T cell mediated cytotoxicity', 'protein autophosphorylation', 'protein folding', 'protein import into nucleus', 'protein refolding', 'protein targeting to lysosome involved in chaperone-mediated autophagy', 'protein transmembrane import into intracellular organelle', 'protein-containing complex disassembly', 'regulation of cell cycle', 'regulation of postsynapse organization', 'regulation of protein complex stability', 'regulation of protein stability', 'response to activity', 'response to estradiol', 'response to ethanol', 'response to heat', 'response to nickel cation', 'response to odorant', 'response to progesterone', 'response to starvation', 'response to xenobiotic stimulus', 'RNA splicing', 'sensory perception of smell', 'skeletal muscle tissue development', 'slow axonal transport', 'synaptic vesicle uncoating', 'vesicle-mediated transport']['aging', 'ATP metabolic process', 'axo-dendritic transport', 'cellular response to cadmium ion', 'cellular response to heat', 'cellular response to unfolded protein', 'cerebellum development', 'chaperone cofactor-dependent protein refolding', 'chaperone-mediated autophagy', 'chaperone-mediated autophagy translocation complex disassembly', 'chaperone-mediated protein folding', 'clathrin coat disassembly', 'estrous cycle', 'forebrain development', 'G1/S transition of mitotic cell cycle', 'kidney development', 'late endosomal microautophagy', 'maintenance of postsynaptic specialization structure', 'modulation by host of viral process', 'mRNA processing', 'negative regulation of cardiac muscle cell apoptotic process', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of supramolecular fiber organization', 'negative regulation of transcription, DNA-templated', 'positive regulation by host of viral genome replication', 'positive regulation of catalytic activity', 'positive regulation of gene expression', 'positive regulation of lysosomal membrane permeability', 'positive regulation of mRNA splicing, via spliceosome', 'positive regulation of phagocytosis', 'positive regulation of protein refolding', 'positive regulation of proteolysis', 'positive regulation of T cell mediated cytotoxicity', 'protein autophosphorylation', 'protein folding', 'protein import into nucleus', 'protein refolding', 'protein targeting to lysosome involved in chaperone-mediated autophagy', 'protein transmembrane import into intracellular organelle', 'protein-containing complex disassembly', 'regulation of cell cycle', 'regulation of postsynapse organization', 'regulation of protein complex stability', 'regulation of protein stability', 'response to activity', 'response to estradiol', 'response to ethanol', 'response to heat', 'response to nickel cation', 'response to odorant', 'response to progesterone', 'response to starvation', 'response to xenobiotic stimulus', 'RNA splicing', 'sensory perception of smell', 'skeletal muscle tissue development', 'slow axonal transport', 'synaptic vesicle uncoating', 'vesicle-mediated transport']
Histone deacetylase 6
1148
Histone deacetylase 6
1120
5.1
83
0.23
Q9UBN7Q9UBN7['aggresome assembly', 'autophagy', 'axonal transport of mitochondrion', 'cellular response to hydrogen peroxide', 'cellular response to misfolded protein', 'cellular response to topologically incorrect protein', 'cilium assembly', 'cilium disassembly', 'collateral sprouting', 'dendritic spine morphogenesis', 'histone deacetylation', 'Hsp90 deacetylation', 'intracellular protein transport', 'lysosome localization', 'negative regulation of hydrogen peroxide metabolic process', 'negative regulation of microtubule depolymerization', 'negative regulation of oxidoreductase activity', 'negative regulation of protein-containing complex assembly', 'negative regulation of protein-containing complex disassembly', 'negative regulation of proteolysis', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization', 'peptidyl-lysine deacetylation', 'polyubiquitinated misfolded protein transport', 'positive regulation of epithelial cell migration', 'positive regulation of hydrogen peroxide-mediated programmed cell death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of signaling receptor activity', 'protein deacetylation', 'protein destabilization', 'protein polyubiquitination', 'protein quality control for misfolded or incompletely synthesized proteins', 'protein-containing complex disassembly', 'regulation of androgen receptor signaling pathway', 'regulation of autophagy', 'regulation of autophagy of mitochondrion', 'regulation of establishment of protein localization', 'regulation of fat cell differentiation', 'regulation of gene expression, epigenetic', 'regulation of macroautophagy', 'regulation of microtubule-based movement', 'regulation of protein stability', 'response to growth factor', 'response to misfolded protein', 'tubulin deacetylation', 'ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway']['aggresome assembly', 'autophagy', 'axonal transport of mitochondrion', 'cellular response to hydrogen peroxide', 'cellular response to misfolded protein', 'cellular response to topologically incorrect protein', 'cilium assembly', 'cilium disassembly', 'collateral sprouting', 'dendritic spine morphogenesis', 'histone deacetylation', 'Hsp90 deacetylation', 'intracellular protein transport', 'lysosome localization', 'negative regulation of hydrogen peroxide metabolic process', 'negative regulation of microtubule depolymerization', 'negative regulation of oxidoreductase activity', 'negative regulation of protein-containing complex assembly', 'negative regulation of protein-containing complex disassembly', 'negative regulation of proteolysis', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization', 'peptidyl-lysine deacetylation', 'polyubiquitinated misfolded protein transport', 'positive regulation of epithelial cell migration', 'positive regulation of hydrogen peroxide-mediated programmed cell death', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of signaling receptor activity', 'protein deacetylation', 'protein destabilization', 'protein polyubiquitination', 'protein quality control for misfolded or incompletely synthesized proteins', 'protein-containing complex disassembly', 'regulation of androgen receptor signaling pathway', 'regulation of autophagy', 'regulation of autophagy of mitochondrion', 'regulation of establishment of protein localization', 'regulation of fat cell differentiation', 'regulation of gene expression, epigenetic', 'regulation of macroautophagy', 'regulation of microtubule-based movement', 'regulation of protein stability', 'response to growth factor', 'response to misfolded protein', 'tubulin deacetylation', 'ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway']
Adenylosuccinate synthetase isozyme 1
281
Adenylosuccinate synthetase isozyme 1
281
5.1
97
0.2
P28650P28650["'de novo' AMP biosynthetic process", 'AMP biosynthetic process', 'AMP salvage', 'aspartate metabolic process', 'IMP metabolic process', 'purine nucleotide metabolic process', 'purine ribonucleoside monophosphate biosynthetic process']["'de novo' AMP biosynthetic process", 'AMP biosynthetic process', 'AMP salvage', 'aspartate metabolic process', 'IMP metabolic process', 'purine nucleotide metabolic process', 'purine ribonucleoside monophosphate biosynthetic process']
Protein-glutamine gamma-glutamyltransferase 2
554
Protein-glutamine gamma-glutamyltransferase 2
554
5.2
65
0.3
P21980P21980['apoptotic cell clearance', 'bone development', 'branching involved in salivary gland morphogenesis', 'cellular response to cocaine', 'cellular response to dopamine', 'cellular response to serotonin', 'negative regulation of endoplasmic reticulum calcium ion concentration', 'peptide cross-linking', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of apoptotic process', 'positive regulation of cell adhesion', 'positive regulation of GTPase activity', 'positive regulation of mitochondrial calcium ion concentration', 'positive regulation of neurogenesis', 'positive regulation of small GTPase mediated signal transduction', 'protein deamination', 'protein homooligomerization', 'proteolysis', 'regulation of apoptotic cell clearance', 'regulation of apoptotic process', 'salivary gland cavitation']['apoptotic cell clearance', 'bone development', 'branching involved in salivary gland morphogenesis', 'cellular response to cocaine', 'cellular response to dopamine', 'cellular response to serotonin', 'negative regulation of endoplasmic reticulum calcium ion concentration', 'peptide cross-linking', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of apoptotic process', 'positive regulation of cell adhesion', 'positive regulation of GTPase activity', 'positive regulation of mitochondrial calcium ion concentration', 'positive regulation of neurogenesis', 'positive regulation of small GTPase mediated signal transduction', 'protein deamination', 'protein homooligomerization', 'proteolysis', 'regulation of apoptotic cell clearance', 'regulation of apoptotic process', 'salivary gland cavitation']
C-terminal-binding protein 2
140
C-terminal-binding protein 2
140
5.2
88
0.22
P56545P56545['cellular response to leukemia inhibitory factor', 'negative regulation of cell population proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of chromatin binding', 'positive regulation of retinoic acid receptor signaling pathway', 'positive regulation of transcription by RNA polymerase II', 'regulation of transcription by RNA polymerase II', 'synaptic vesicle docking', 'viral genome replication', 'white fat cell differentiation']['cellular response to leukemia inhibitory factor', 'negative regulation of cell population proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation of chromatin binding', 'positive regulation of retinoic acid receptor signaling pathway', 'positive regulation of transcription by RNA polymerase II', 'regulation of transcription by RNA polymerase II', 'synaptic vesicle docking', 'viral genome replication', 'white fat cell differentiation']
DNA polymerase lambda
300
DNA polymerase lambda
300
5.2
64
0.3
Q9UGP5Q9UGP5['base-excision repair, gap-filling', 'DNA biosynthetic process', 'DNA replication', 'double-strand break repair via homologous recombination', 'double-strand break repair via nonhomologous end joining', 'nucleotide-excision repair', 'somatic hypermutation of immunoglobulin genes']['base-excision repair, gap-filling', 'DNA biosynthetic process', 'DNA replication', 'double-strand break repair via homologous recombination', 'double-strand break repair via nonhomologous end joining', 'nucleotide-excision repair', 'somatic hypermutation of immunoglobulin genes']
Urokinase plasminogen activator surface receptor
46
Urokinase plasminogen activator surface receptor
93
5.1
68
0.29
Q03405Q03405['blood coagulation', 'chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'negative regulation of intrinsic apoptotic signaling pathway', 'positive regulation of DNA binding', 'positive regulation of epidermal growth factor receptor signaling pathway', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of protein phosphorylation', 'positive regulation of release of cytochrome c from mitochondria', 'regulation of cell adhesion', 'regulation of fibrinolysis', 'regulation of plasminogen activation', 'regulation of proteolysis', 'signal transduction', 'urokinase plasminogen activator signaling pathway']['blood coagulation', 'chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'negative regulation of intrinsic apoptotic signaling pathway', 'positive regulation of DNA binding', 'positive regulation of epidermal growth factor receptor signaling pathway', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of protein phosphorylation', 'positive regulation of release of cytochrome c from mitochondria', 'regulation of cell adhesion', 'regulation of fibrinolysis', 'regulation of plasminogen activation', 'regulation of proteolysis', 'signal transduction', 'urokinase plasminogen activator signaling pathway']
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
193
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
193
4.9
78
0.26
Q9TTF5Q9TTF5['metabolic process']['metabolic process']
Pygopus homolog 1
371
Pygopus homolog 1
346
5.2
68
0.28
Q9Y3Y4Q9Y3Y4['canonical Wnt signaling pathway', 'hematopoietic progenitor cell differentiation', 'kidney development', 'positive regulation of transcription by RNA polymerase II', 'protein localization to nucleus', 'spermatid nucleus differentiation']['canonical Wnt signaling pathway', 'hematopoietic progenitor cell differentiation', 'kidney development', 'positive regulation of transcription by RNA polymerase II', 'protein localization to nucleus', 'spermatid nucleus differentiation']
NADPH oxidase activator 1
451
NADPH oxidase activator 1
451
5.0
56
0.36
Q86UR1Q86UR1['regulation of hydrogen peroxide metabolic process', 'regulation of respiratory burst', 'superoxide anion generation', 'superoxide metabolic process']['regulation of hydrogen peroxide metabolic process', 'regulation of respiratory burst', 'superoxide anion generation', 'superoxide metabolic process']
Regulator of G-protein signaling 16
123
Regulator of G-protein signaling 16
123
5.0
75
0.27
O15492O15492['G protein-coupled receptor signaling pathway', 'negative regulation of signal transduction', 'positive regulation of GTPase activity', 'regulation of G protein-coupled receptor signaling pathway', 'visual perception']['G protein-coupled receptor signaling pathway', 'negative regulation of signal transduction', 'positive regulation of GTPase activity', 'regulation of G protein-coupled receptor signaling pathway', 'visual perception']
TNF receptor-associated factor 5
401
TNF receptor-associated factor 5
438
4.9
69
0.29
P70191P70191['apoptotic process', 'interleukin-17-mediated signaling pathway', 'mRNA stabilization', 'positive regulation of cell population proliferation', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of JNK cascade', 'positive regulation of NF-kappaB transcription factor activity', 'protein K63-linked ubiquitination', 'regulation of apoptotic process', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'signal transduction', 'signal transduction involved in regulation of gene expression', 'tumor necrosis factor-mediated signaling pathway']['apoptotic process', 'interleukin-17-mediated signaling pathway', 'mRNA stabilization', 'positive regulation of cell population proliferation', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of JNK cascade', 'positive regulation of NF-kappaB transcription factor activity', 'protein K63-linked ubiquitination', 'regulation of apoptotic process', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'signal transduction', 'signal transduction involved in regulation of gene expression', 'tumor necrosis factor-mediated signaling pathway']
Protein MIS12 homolog
63
Polyamine-modulated factor 1
61
4.9
54
0.38
Q9H081Q6P1K2['attachment of mitotic spindle microtubules to kinetochore', 'cell division', 'chromosome segregation', 'kinetochore assembly', 'mitotic sister chromatid segregation', 'protein localization to kinetochore']['cell cycle', 'cell division', 'chromosome segregation', 'transcription by RNA polymerase II']
Bile acid receptor
429
Bile acid receptor
429
5.0
68
0.3
Q62735Q62735['bile acid and bile salt transport', 'bile acid metabolic process', 'bile acid signaling pathway', 'cell differentiation', 'cell-cell junction assembly', 'cellular glucose homeostasis', 'cellular response to bile acid', 'cellular response to fatty acid', 'cellular response to lipopolysaccharide', 'cellular response to organonitrogen compound', 'cellular response to xenobiotic stimulus', 'cellular triglyceride homeostasis', 'cholesterol homeostasis', 'defense response to bacterium', 'digestive tract development', 'fatty acid homeostasis', 'glucose homeostasis', 'hepatocyte proliferation', 'histone H3-R17 methylation', 'innate immune response', 'intracellular bile acid receptor signaling pathway', 'intracellular receptor signaling pathway', 'leukocyte migration involved in inflammatory response', 'lipid localization', 'liver regeneration', 'negative regulation of apoptotic process', 'negative regulation of collagen biosynthetic process', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of inflammatory response', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-1 production', 'negative regulation of interleukin-2 production', 'negative regulation of interleukin-6 production', 'negative regulation of monocyte chemotactic protein-1 production', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of triglyceride biosynthetic process', 'negative regulation of tumor necrosis factor production', 'negative regulation of tumor necrosis factor-mediated signaling pathway', 'negative regulation of very-low-density lipoprotein particle remodeling', 'Notch signaling pathway', 'positive regulation of adipose tissue development', 'positive regulation of ammonia assimilation cycle', 'positive regulation of gene expression', 'positive regulation of glutamate metabolic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of interleukin-17 production', 'positive regulation of phosphatidic acid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of bile acid secretion', 'regulation of carbohydrate metabolic process', 'regulation of gene expression', 'regulation of insulin secretion involved in cellular response to glucose stimulus', 'regulation of lipid storage', 'regulation of low-density lipoprotein particle clearance', 'regulation of transcription by RNA polymerase II', 'regulation of urea metabolic process', 'response to 17alpha-ethynylestradiol', 'response to cholesterol', 'response to ethanol', 'response to fenofibrate', 'response to glucose', 'response to lipopolysaccharide', 'response to norepinephrine', 'response to nutrient levels', 'response to organic cyclic compound', 'response to xenobiotic stimulus', 'toll-like receptor 4 signaling pathway', 'toll-like receptor 9 signaling pathway', 'triglyceride homeostasis']['bile acid and bile salt transport', 'bile acid metabolic process', 'bile acid signaling pathway', 'cell differentiation', 'cell-cell junction assembly', 'cellular glucose homeostasis', 'cellular response to bile acid', 'cellular response to fatty acid', 'cellular response to lipopolysaccharide', 'cellular response to organonitrogen compound', 'cellular response to xenobiotic stimulus', 'cellular triglyceride homeostasis', 'cholesterol homeostasis', 'defense response to bacterium', 'digestive tract development', 'fatty acid homeostasis', 'glucose homeostasis', 'hepatocyte proliferation', 'histone H3-R17 methylation', 'innate immune response', 'intracellular bile acid receptor signaling pathway', 'intracellular receptor signaling pathway', 'leukocyte migration involved in inflammatory response', 'lipid localization', 'liver regeneration', 'negative regulation of apoptotic process', 'negative regulation of collagen biosynthetic process', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of inflammatory response', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-1 production', 'negative regulation of interleukin-2 production', 'negative regulation of interleukin-6 production', 'negative regulation of monocyte chemotactic protein-1 production', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of triglyceride biosynthetic process', 'negative regulation of tumor necrosis factor production', 'negative regulation of tumor necrosis factor-mediated signaling pathway', 'negative regulation of very-low-density lipoprotein particle remodeling', 'Notch signaling pathway', 'positive regulation of adipose tissue development', 'positive regulation of ammonia assimilation cycle', 'positive regulation of gene expression', 'positive regulation of glutamate metabolic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of interleukin-17 production', 'positive regulation of phosphatidic acid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of bile acid secretion', 'regulation of carbohydrate metabolic process', 'regulation of gene expression', 'regulation of insulin secretion involved in cellular response to glucose stimulus', 'regulation of lipid storage', 'regulation of low-density lipoprotein particle clearance', 'regulation of transcription by RNA polymerase II', 'regulation of urea metabolic process', 'response to 17alpha-ethynylestradiol', 'response to cholesterol', 'response to ethanol', 'response to fenofibrate', 'response to glucose', 'response to lipopolysaccharide', 'response to norepinephrine', 'response to nutrient levels', 'response to organic cyclic compound', 'response to xenobiotic stimulus', 'toll-like receptor 4 signaling pathway', 'toll-like receptor 9 signaling pathway', 'triglyceride homeostasis']
Complement C1s subcomponent
549
Complement C1s subcomponent
425
5.0
75
0.27
P09871P09871['complement activation, classical pathway', 'innate immune response', 'proteolysis']['complement activation, classical pathway', 'innate immune response', 'proteolysis']
Estrogen receptor
530
Estrogen receptor
417
5.0
48
0.42
P03372P03372['androgen metabolic process', 'antral ovarian follicle growth', 'cellular response to estradiol stimulus', 'cellular response to estrogen stimulus', 'chromatin remodeling', 'epithelial cell development', 'epithelial cell proliferation involved in mammary gland duct elongation', 'fibroblast proliferation', 'intracellular estrogen receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'male gonad development', 'mammary gland alveolus development', 'mammary gland branching involved in pregnancy', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of gene expression', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of miRNA maturation', 'negative regulation of transcription by RNA polymerase II', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of fibroblast proliferation', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of phospholipase C activity', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis', 'prostate epithelial cord elongation', 'protein localization to chromatin', 'regulation of branching involved in prostate gland morphogenesis', 'regulation of epithelial cell apoptotic process', 'regulation of inflammatory response', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to estradiol', 'response to estrogen', 'signal transduction', 'stem cell differentiation', 'transcription by RNA polymerase II', 'uterus development', 'vagina development']['androgen metabolic process', 'antral ovarian follicle growth', 'cellular response to estradiol stimulus', 'cellular response to estrogen stimulus', 'chromatin remodeling', 'epithelial cell development', 'epithelial cell proliferation involved in mammary gland duct elongation', 'fibroblast proliferation', 'intracellular estrogen receptor signaling pathway', 'intracellular steroid hormone receptor signaling pathway', 'male gonad development', 'mammary gland alveolus development', 'mammary gland branching involved in pregnancy', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of gene expression', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of miRNA maturation', 'negative regulation of transcription by RNA polymerase II', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of fibroblast proliferation', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of phospholipase C activity', 'positive regulation of RNA polymerase II transcription preinitiation complex assembly', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis', 'prostate epithelial cord elongation', 'protein localization to chromatin', 'regulation of branching involved in prostate gland morphogenesis', 'regulation of epithelial cell apoptotic process', 'regulation of inflammatory response', 'regulation of toll-like receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to estradiol', 'response to estrogen', 'signal transduction', 'stem cell differentiation', 'transcription by RNA polymerase II', 'uterus development', 'vagina development']
Probable ATP-dependent RNA helicase DDX20
98
Probable ATP-dependent RNA helicase DDX20
98
4.9
71
0.29
Q9UHI6Q9UHI6['negative regulation of cell population proliferation', 'negative regulation of transcription by RNA polymerase II', 'oogenesis', 'positive regulation of apoptotic process', 'regulation of steroid biosynthetic process', 'RNA processing', 'spliceosomal snRNP assembly', 'spliceosomal tri-snRNP complex assembly']['negative regulation of cell population proliferation', 'negative regulation of transcription by RNA polymerase II', 'oogenesis', 'positive regulation of apoptotic process', 'regulation of steroid biosynthetic process', 'RNA processing', 'spliceosomal snRNP assembly', 'spliceosomal tri-snRNP complex assembly']
BLM protein
380
BLM protein
380
5.0
77
0.26
Q3B7X0Q3B7X0['DNA replication']['DNA replication']
Protein PML
91
Protein PML
91
5.2
65
0.29
P29590P29590['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'apoptotic process', 'branching involved in mammary gland duct morphogenesis', 'cell fate commitment', 'cellular response to interleukin-4', 'cellular response to leukemia inhibitory factor', 'cellular senescence', 'circadian regulation of gene expression', 'common-partner SMAD protein phosphorylation', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'endoplasmic reticulum calcium ion homeostasis', 'entrainment of circadian clock by photoperiod', 'extrinsic apoptotic signaling pathway', 'fibroblast migration', 'innate immune response', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'intrinsic apoptotic signaling pathway in response to oxidative stress', 'maintenance of protein location in nucleus', 'myeloid cell differentiation', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of interleukin-1 beta production', 'negative regulation of mitotic cell cycle', 'negative regulation of telomerase activity', 'negative regulation of telomere maintenance via telomerase', 'negative regulation of transcription, DNA-templated', 'negative regulation of translation in response to oxidative stress', 'negative regulation of ubiquitin-dependent protein catabolic process', 'oncogene-induced cell senescence', 'PML body organization', 'positive regulation of apoptotic process involved in mammary gland involution', 'positive regulation of defense response to virus by host', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of fibroblast proliferation', 'positive regulation of histone deacetylation', 'positive regulation of peptidyl-lysine acetylation', 'positive regulation of protein localization to chromosome, telomeric region', 'positive regulation of signal transduction by p53 class mediator', 'positive regulation of telomere maintenance', 'positive regulation of transcription, DNA-templated', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein import into nucleus', 'protein stabilization', 'protein targeting', 'protein-containing complex assembly', 'protein-containing complex localization', 'regulation of calcium ion transport into cytosol', 'regulation of cell adhesion', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of double-strand break repair', 'regulation of transcription, DNA-templated', 'response to cytokine', 'response to gamma radiation', 'response to hypoxia', 'response to UV', 'retinoic acid receptor signaling pathway', 'suppression of viral release by host', 'transforming growth factor beta receptor signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'apoptotic process', 'branching involved in mammary gland duct morphogenesis', 'cell fate commitment', 'cellular response to interleukin-4', 'cellular response to leukemia inhibitory factor', 'cellular senescence', 'circadian regulation of gene expression', 'common-partner SMAD protein phosphorylation', 'DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest', 'endoplasmic reticulum calcium ion homeostasis', 'entrainment of circadian clock by photoperiod', 'extrinsic apoptotic signaling pathway', 'fibroblast migration', 'innate immune response', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'intrinsic apoptotic signaling pathway in response to oxidative stress', 'maintenance of protein location in nucleus', 'myeloid cell differentiation', 'negative regulation of angiogenesis', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of interleukin-1 beta production', 'negative regulation of mitotic cell cycle', 'negative regulation of telomerase activity', 'negative regulation of telomere maintenance via telomerase', 'negative regulation of transcription, DNA-templated', 'negative regulation of translation in response to oxidative stress', 'negative regulation of ubiquitin-dependent protein catabolic process', 'oncogene-induced cell senescence', 'PML body organization', 'positive regulation of apoptotic process involved in mammary gland involution', 'positive regulation of defense response to virus by host', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of fibroblast proliferation', 'positive regulation of histone deacetylation', 'positive regulation of peptidyl-lysine acetylation', 'positive regulation of protein localization to chromosome, telomeric region', 'positive regulation of signal transduction by p53 class mediator', 'positive regulation of telomere maintenance', 'positive regulation of transcription, DNA-templated', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein import into nucleus', 'protein stabilization', 'protein targeting', 'protein-containing complex assembly', 'protein-containing complex localization', 'regulation of calcium ion transport into cytosol', 'regulation of cell adhesion', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of double-strand break repair', 'regulation of transcription, DNA-templated', 'response to cytokine', 'response to gamma radiation', 'response to hypoxia', 'response to UV', 'retinoic acid receptor signaling pathway', 'suppression of viral release by host', 'transforming growth factor beta receptor signaling pathway']
MHC class II HLA-DQ-alpha chain
11
MHC class II antigen
111
5.1
92
0.21
Q30066Q67AJ6['adaptive immune response', 'antigen processing and presentation of peptide or polysaccharide antigen via MHC class II']['adaptive immune response', 'antigen processing and presentation of peptide or polysaccharide antigen via MHC class II']
Killer cell lectin-like receptor 3
154
Killer cell lectin-like receptor 3
149
5.1
75
0.26
Q61198Q61198['cell adhesion']['cell adhesion']
Peptidyl-prolyl cis-trans isomerase FKBP5
183
Peptidyl-prolyl cis-trans isomerase FKBP5
183
5.1
66
0.3
Q13451Q13451['chaperone-mediated protein folding', 'protein folding', 'protein peptidyl-prolyl isomerization', 'response to bacterium']['chaperone-mediated protein folding', 'protein folding', 'protein peptidyl-prolyl isomerization', 'response to bacterium']
Cysteine desulfurase, mitochondrial
381
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
95
4.8
86
0.24
Q9Y697Q9H1K1['[2Fe-2S] cluster assembly', 'iron incorporation into metallo-sulfur cluster', 'iron-sulfur cluster assembly', 'Mo-molybdopterin cofactor biosynthetic process']['cellular iron ion homeostasis', 'iron-sulfur cluster assembly', 'negative regulation of iron ion import across plasma membrane', 'positive regulation of aconitate hydratase activity', 'positive regulation of mitochondrial electron transport, NADH to ubiquinone']
Integrin beta-2
33
Integrin beta-2
449
4.8
64
0.33
P05107P05107['amyloid-beta clearance', 'apoptotic process', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-cell adhesion', 'cell-cell adhesion via plasma-membrane adhesion molecules', 'cell-cell signaling', 'cell-matrix adhesion', 'cellular response to low-density lipoprotein particle stimulus', 'endodermal cell differentiation', 'heterotypic cell-cell adhesion', 'inflammatory response', 'integrin-mediated signaling pathway', 'leukocyte cell-cell adhesion', 'microglial cell activation', 'negative regulation of dopamine metabolic process', 'neutrophil chemotaxis', 'neutrophil migration', 'phagocytosis, engulfment', 'positive regulation of leukocyte adhesion to vascular endothelial cell', 'positive regulation of neuron death', 'positive regulation of neutrophil degranulation', 'positive regulation of prostaglandin-E synthase activity', 'positive regulation of protein targeting to membrane', 'positive regulation of superoxide anion generation', 'receptor clustering', 'receptor internalization', 'receptor-mediated endocytosis', 'regulation of cell shape', 'regulation of peptidyl-tyrosine phosphorylation']['amyloid-beta clearance', 'apoptotic process', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-cell adhesion', 'cell-cell adhesion via plasma-membrane adhesion molecules', 'cell-cell signaling', 'cell-matrix adhesion', 'cellular response to low-density lipoprotein particle stimulus', 'endodermal cell differentiation', 'heterotypic cell-cell adhesion', 'inflammatory response', 'integrin-mediated signaling pathway', 'leukocyte cell-cell adhesion', 'microglial cell activation', 'negative regulation of dopamine metabolic process', 'neutrophil chemotaxis', 'neutrophil migration', 'phagocytosis, engulfment', 'positive regulation of leukocyte adhesion to vascular endothelial cell', 'positive regulation of neuron death', 'positive regulation of neutrophil degranulation', 'positive regulation of prostaglandin-E synthase activity', 'positive regulation of protein targeting to membrane', 'positive regulation of superoxide anion generation', 'receptor clustering', 'receptor internalization', 'receptor-mediated endocytosis', 'regulation of cell shape', 'regulation of peptidyl-tyrosine phosphorylation']
Protein fem-1 homolog B
186
Folliculin-interacting protein 1
608
5.1
62
0.32
Q9Z2G0Q68FD7['apoptotic process', 'branching involved in prostate gland morphogenesis', 'epithelial cell maturation', 'epithelial cell maturation involved in prostate gland development', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination', 'regulation of DNA damage checkpoint', 'regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'regulation of ubiquitin-protein transferase activity', 'ubiquitin-dependent protein catabolic process via the C-end degron rule pathway']['B cell apoptotic process', 'cellular response to starvation', 'immature B cell differentiation', 'negative regulation of cell population proliferation', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of TOR signaling', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of B cell apoptotic process', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of TOR signaling', 'regulation of pro-B cell differentiation', 'regulation of protein phosphorylation', 'TOR signaling']
Tropomyosin alpha-1 chain
190
Tropomyosin alpha-1 chain
190
5.2
56
0.34
1
✔P58772P58772[][]
E3 ubiquitin-protein ligase RNF31
874
E3 ubiquitin-protein ligase RNF31
885
5.0
63
0.32
Q96EP0Q96EP0['CD40 signaling pathway', 'defense response to bacterium', 'negative regulation of necroptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of xenophagy', 'protein linear polyubiquitination', 'protein polyubiquitination', 'T cell receptor signaling pathway']['CD40 signaling pathway', 'defense response to bacterium', 'negative regulation of necroptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of xenophagy', 'protein linear polyubiquitination', 'protein polyubiquitination', 'T cell receptor signaling pathway']
STE20/SPS1-related proline-alanine-rich protein kinase
525
STE20/SPS1-related proline-alanine-rich protein kinase
525
5.0
70
0.28
Q9UEW8Q9UEW8['cellular chloride ion homeostasis', 'cellular hypotonic response', 'cellular response to chemokine', 'cellular response to potassium ion', 'chemokine (C-X-C motif) ligand 12 signaling pathway', 'inflammatory response', 'intracellular signal transduction', 'macrophage activation', 'maintenance of lens transparency', 'negative regulation of creatine transmembrane transporter activity', 'negative regulation of pancreatic juice secretion', 'negative regulation of potassium ion transmembrane transport', 'negative regulation of potassium ion transmembrane transporter activity', 'negative regulation of sodium ion transmembrane transporter activity', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of ion transmembrane transporter activity', 'positive regulation of p38MAPK cascade', 'positive regulation of potassium ion transport', 'positive regulation of T cell chemotaxis', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of blood pressure', 'regulation of inflammatory response', 'response to aldosterone', 'response to dietary excess', 'signal transduction', 'sodium ion transmembrane transport']['cellular chloride ion homeostasis', 'cellular hypotonic response', 'cellular response to chemokine', 'cellular response to potassium ion', 'chemokine (C-X-C motif) ligand 12 signaling pathway', 'inflammatory response', 'intracellular signal transduction', 'macrophage activation', 'maintenance of lens transparency', 'negative regulation of creatine transmembrane transporter activity', 'negative regulation of pancreatic juice secretion', 'negative regulation of potassium ion transmembrane transport', 'negative regulation of potassium ion transmembrane transporter activity', 'negative regulation of sodium ion transmembrane transporter activity', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of ion transmembrane transporter activity', 'positive regulation of p38MAPK cascade', 'positive regulation of potassium ion transport', 'positive regulation of T cell chemotaxis', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of blood pressure', 'regulation of inflammatory response', 'response to aldosterone', 'response to dietary excess', 'signal transduction', 'sodium ion transmembrane transport']
DNA polymerase delta subunit 2
314
DNA polymerase delta subunit 2
314
5.2
76
0.25
P49005P49005['DNA biosynthetic process', 'DNA replication', 'DNA strand elongation involved in DNA replication', 'DNA-templated DNA replication', 'error-prone translesion synthesis']['DNA biosynthetic process', 'DNA replication', 'DNA strand elongation involved in DNA replication', 'DNA-templated DNA replication', 'error-prone translesion synthesis']
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
38
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
38
5.3
69
0.28
O43765O43765['negative regulation of ER-associated ubiquitin-dependent protein catabolic process', 'negative regulation of ubiquitin-dependent protein catabolic process', 'positive regulation of ER-associated ubiquitin-dependent protein catabolic process', 'post-translational protein targeting to endoplasmic reticulum membrane', 'tail-anchored membrane protein insertion into ER membrane', 'ubiquitin-dependent ERAD pathway']['negative regulation of ER-associated ubiquitin-dependent protein catabolic process', 'negative regulation of ubiquitin-dependent protein catabolic process', 'positive regulation of ER-associated ubiquitin-dependent protein catabolic process', 'post-translational protein targeting to endoplasmic reticulum membrane', 'tail-anchored membrane protein insertion into ER membrane', 'ubiquitin-dependent ERAD pathway']
Guanine nucleotide exchange factor for Rab-3A
97
Guanine nucleotide exchange factor for Rab-3A
97
5.3
51
0.37
Q8TBN0Q8TBN0['exocytosis', 'protein transport']['exocytosis', 'protein transport']
C-C motif chemokine 16
37
C-C motif chemokine 16
37
5.2
74
0.26
O15467O15467['cell communication', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']['cell communication', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity']
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
201
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
201
5.4
78
0.24
P28907P28907['apoptotic signaling pathway', 'artery smooth muscle contraction', 'B cell proliferation', 'B cell receptor signaling pathway', 'female pregnancy', 'long-term synaptic depression', 'NAD metabolic process', 'negative regulation of apoptotic process', 'negative regulation of bone resorption', 'negative regulation of neuron projection development', 'negative regulation of transcription, DNA-templated', 'positive regulation of B cell proliferation', 'positive regulation of cell growth', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of insulin secretion', 'positive regulation of transcription, DNA-templated', 'positive regulation of vasoconstriction', 'response to estradiol', 'response to hydroperoxide', 'response to hypoxia', 'response to interleukin-1', 'response to progesterone', 'response to retinoic acid', 'response to xenobiotic stimulus', 'signal transduction']['apoptotic signaling pathway', 'artery smooth muscle contraction', 'B cell proliferation', 'B cell receptor signaling pathway', 'female pregnancy', 'long-term synaptic depression', 'NAD metabolic process', 'negative regulation of apoptotic process', 'negative regulation of bone resorption', 'negative regulation of neuron projection development', 'negative regulation of transcription, DNA-templated', 'positive regulation of B cell proliferation', 'positive regulation of cell growth', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of insulin secretion', 'positive regulation of transcription, DNA-templated', 'positive regulation of vasoconstriction', 'response to estradiol', 'response to hydroperoxide', 'response to hypoxia', 'response to interleukin-1', 'response to progesterone', 'response to retinoic acid', 'response to xenobiotic stimulus', 'signal transduction']
cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
178
cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
178
5.4
80
0.23
B7Z5J6B7Z5J6['small GTPase mediated signal transduction']['small GTPase mediated signal transduction']
Pygopus homolog 1
346
Pygopus homolog 1
346
5.2
68
0.28
Q9Y3Y4Q9Y3Y4['canonical Wnt signaling pathway', 'hematopoietic progenitor cell differentiation', 'kidney development', 'positive regulation of transcription by RNA polymerase II', 'protein localization to nucleus', 'spermatid nucleus differentiation']['canonical Wnt signaling pathway', 'hematopoietic progenitor cell differentiation', 'kidney development', 'positive regulation of transcription by RNA polymerase II', 'protein localization to nucleus', 'spermatid nucleus differentiation']
Kallikrein-7
137
Kallikrein-7
137
5.6
66
0.27
P49862P49862['epidermis development', 'extracellular matrix disassembly', 'positive regulation of antibacterial peptide production', 'proteolysis']['epidermis development', 'extracellular matrix disassembly', 'positive regulation of antibacterial peptide production', 'proteolysis']
Protein MIS12 homolog
63
Polyamine-modulated factor 1
64
5.3
54
0.35
Q9H081Q6P1K2['attachment of mitotic spindle microtubules to kinetochore', 'cell division', 'chromosome segregation', 'kinetochore assembly', 'mitotic sister chromatid segregation', 'protein localization to kinetochore']['cell cycle', 'cell division', 'chromosome segregation', 'transcription by RNA polymerase II']
Lysozyme C
127
Lysozyme C
6
6.0
70
0.24
P11375P11375['cytolysis', 'defense response to bacterium', 'metabolic process']['cytolysis', 'defense response to bacterium', 'metabolic process']
C-C motif chemokine 8
34
C-C motif chemokine 8
34
6.0
75
0.22
P80075P80075['antimicrobial humoral immune response mediated by antimicrobial peptide', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation by host of viral genome replication', 'negative regulation of leukocyte proliferation', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of leukocyte migration', 'response to virus', 'signal transduction']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation by host of viral genome replication', 'negative regulation of leukocyte proliferation', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of leukocyte migration', 'response to virus', 'signal transduction']
Insulin-like growth factor-binding protein 4
204
Insulin-like growth factor I
96
6.0
79
0.21
P22692P05019['inflammatory response', 'MAPK cascade', 'negative regulation of canonical Wnt signaling pathway', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'regulation of cell growth', 'regulation of glucose metabolic process', 'regulation of insulin-like growth factor receptor signaling pathway', 'signal transduction', 'type B pancreatic cell proliferation']['activation of protein kinase B activity', 'bone mineralization involved in bone maturation', 'cell activation', 'cell population proliferation', 'cellular response to amyloid-beta', 'ERK1 and ERK2 cascade', 'glycolate metabolic process', 'insulin-like growth factor receptor signaling pathway', 'muscle hypertrophy', 'muscle organ development', 'myoblast differentiation', 'myoblast proliferation', 'myotube cell development', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of gene expression', 'negative regulation of interleukin-1 beta production', 'negative regulation of neuroinflammatory response', 'negative regulation of oocyte development', 'negative regulation of release of cytochrome c from mitochondria', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of tumor necrosis factor production', 'negative regulation of vascular associated smooth muscle cell apoptotic process', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol-mediated signaling', 'positive regulation of activated T cell proliferation', 'positive regulation of calcineurin-NFAT signaling cascade', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of DNA binding', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Ras protein signal transduction', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of trophectodermal cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase B signaling', 'protein stabilization', 'proteoglycan biosynthetic process', 'Ras protein signal transduction', 'regulation of gene expression', 'regulation of multicellular organism growth', 'regulation of protein phosphorylation', 'response to heat', 'signal transduction', 'skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration', 'skeletal system development', 'wound healing']
DNA-binding protein SMUBP-2
191
DNA-binding protein SMUBP-2
191
6.0
45
0.37
P38935P38935['DNA duplex unwinding', 'RNA secondary structure unwinding']['DNA duplex unwinding', 'RNA secondary structure unwinding']
Mothers against decapentaplegic homolog 2
380
Zinc finger FYVE domain-containing protein 9
783
5.8
66
0.26
Q15796O95405['activin receptor signaling pathway', 'adrenal gland development', 'anatomical structure morphogenesis', 'anterior/posterior pattern specification', 'BMP signaling pathway', 'cell differentiation', 'cell fate commitment', 'common-partner SMAD protein phosphorylation', 'embryonic cranial skeleton morphogenesis', 'embryonic foregut morphogenesis', 'endoderm formation', 'gastrulation', 'in utero embryonic development', 'insulin secretion', 'intracellular signal transduction', 'lung development', 'mesoderm formation', 'negative regulation of cell population proliferation', 'negative regulation of transcription, DNA-templated', 'nodal signaling pathway', 'organ growth', 'pancreas development', 'paraxial mesoderm morphogenesis', 'pericardium development', 'positive regulation of BMP signaling pathway', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of gene expression', 'positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'post-embryonic development', 'primary miRNA processing', 'regulation of binding', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to glucose', 'secondary palate development', 'signal transduction involved in regulation of gene expression', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transcription, DNA-templated', 'transforming growth factor beta receptor signaling pathway', 'ureteric bud development', 'wound healing', 'zygotic specification of dorsal/ventral axis']['endocytosis', 'endosomal transport', 'transforming growth factor beta receptor signaling pathway']
cGMP-dependent 3',5'-cyclic phosphodiesterase
234
cGMP-dependent 3',5'-cyclic phosphodiesterase
234
5.7
81
0.22
O00408O00408['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'aorta development', 'cAMP-mediated signaling', 'cellular response to 2,3,7,8-tetrachlorodibenzodioxine', 'cellular response to cAMP', 'cellular response to cGMP', 'cellular response to granulocyte macrophage colony-stimulating factor stimulus', 'cellular response to macrophage colony-stimulating factor stimulus', 'cellular response to mechanical stimulus', 'cellular response to transforming growth factor beta stimulus', 'cellular response to xenobiotic stimulus', 'cGMP catabolic process', 'cGMP-mediated signaling', 'establishment of endothelial barrier', 'heart valve development', 'monocyte differentiation', 'negative regulation of cAMP-mediated signaling', 'negative regulation of cGMP-mediated signaling', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of vascular permeability', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of vascular permeability', 'regulation of cAMP-mediated signaling', 'regulation of cGMP-mediated signaling', 'regulation of mitochondrion organization', 'signal transduction', 'ventricular septum development']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'aorta development', 'cAMP-mediated signaling', 'cellular response to 2,3,7,8-tetrachlorodibenzodioxine', 'cellular response to cAMP', 'cellular response to cGMP', 'cellular response to granulocyte macrophage colony-stimulating factor stimulus', 'cellular response to macrophage colony-stimulating factor stimulus', 'cellular response to mechanical stimulus', 'cellular response to transforming growth factor beta stimulus', 'cellular response to xenobiotic stimulus', 'cGMP catabolic process', 'cGMP-mediated signaling', 'establishment of endothelial barrier', 'heart valve development', 'monocyte differentiation', 'negative regulation of cAMP-mediated signaling', 'negative regulation of cGMP-mediated signaling', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of vascular permeability', 'positive regulation of gene expression', 'positive regulation of inflammatory response', 'positive regulation of vascular permeability', 'regulation of cAMP-mediated signaling', 'regulation of cGMP-mediated signaling', 'regulation of mitochondrion organization', 'signal transduction', 'ventricular septum development']
Glucocorticoid receptor
463
Glucocorticoid receptor
463
5.9
69
0.25
P79269P79269['cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'chromatin organization', 'positive regulation of transcription by RNA polymerase II']['cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'chromatin organization', 'positive regulation of transcription by RNA polymerase II']
Progesterone receptor
609
Progesterone receptor
609
5.8
68
0.25
P06401P06401['cell-cell signaling', 'glandular epithelial cell maturation', 'intracellular steroid hormone receptor signaling pathway', 'lung alveolus development', 'negative regulation of gene expression', 'ovulation from ovarian follicle', 'paracrine signaling', 'positive regulation of gene expression', 'positive regulation of transcription by RNA polymerase II', 'progesterone receptor signaling pathway', 'regulation of epithelial cell proliferation', 'regulation of transcription by RNA polymerase II', 'signal transduction', 'tertiary branching involved in mammary gland duct morphogenesis']['cell-cell signaling', 'glandular epithelial cell maturation', 'intracellular steroid hormone receptor signaling pathway', 'lung alveolus development', 'negative regulation of gene expression', 'ovulation from ovarian follicle', 'paracrine signaling', 'positive regulation of gene expression', 'positive regulation of transcription by RNA polymerase II', 'progesterone receptor signaling pathway', 'regulation of epithelial cell proliferation', 'regulation of transcription by RNA polymerase II', 'signal transduction', 'tertiary branching involved in mammary gland duct morphogenesis']
Vesicle-associated membrane protein 7
21
Vesicle-associated membrane protein 7
21
5.8
65
0.26
P70280P70280['calcium-ion regulated exocytosis', 'endoplasmic reticulum to Golgi vesicle-mediated transport', 'endosome to lysosome transport', 'eosinophil degranulation', 'exocytosis', 'Golgi to plasma membrane protein transport', 'natural killer cell degranulation', 'neutrophil degranulation', 'phagocytosis, engulfment', 'positive regulation of dendrite morphogenesis', 'positive regulation of histamine secretion by mast cell', 'regulation of protein targeting to vacuolar membrane', 'SNARE complex assembly', 'triglyceride transport', 'vesicle fusion', 'vesicle fusion with Golgi apparatus', 'vesicle transport along microtubule', 'vesicle-mediated transport']['calcium-ion regulated exocytosis', 'endoplasmic reticulum to Golgi vesicle-mediated transport', 'endosome to lysosome transport', 'eosinophil degranulation', 'exocytosis', 'Golgi to plasma membrane protein transport', 'natural killer cell degranulation', 'neutrophil degranulation', 'phagocytosis, engulfment', 'positive regulation of dendrite morphogenesis', 'positive regulation of histamine secretion by mast cell', 'regulation of protein targeting to vacuolar membrane', 'SNARE complex assembly', 'triglyceride transport', 'vesicle fusion', 'vesicle fusion with Golgi apparatus', 'vesicle transport along microtubule', 'vesicle-mediated transport']
MORC family CW-type zinc finger protein 3
446
MORC family CW-type zinc finger protein 3
413
5.9
75
0.23
Q14149Q14149['innate immune response', 'maintenance of protein location in nucleus', 'negative regulation of fibroblast proliferation', 'peptidyl-serine phosphorylation', 'positive regulation of cellular senescence', 'post-embryonic development', 'protein phosphorylation', 'protein stabilization']['innate immune response', 'maintenance of protein location in nucleus', 'negative regulation of fibroblast proliferation', 'peptidyl-serine phosphorylation', 'positive regulation of cellular senescence', 'post-embryonic development', 'protein phosphorylation', 'protein stabilization']
Protein arginine N-methyltransferase 8
295
Protein arginine N-methyltransferase 8
295
4.1
81
0.3
Q9NR22Q9NR22['histone methylation', 'peptidyl-arginine methylation', 'peptidyl-arginine methylation, to asymmetrical-dimethyl arginine', 'protein homooligomerization', 'protein methylation', 'regulation of protein binding']['histone methylation', 'peptidyl-arginine methylation', 'peptidyl-arginine methylation, to asymmetrical-dimethyl arginine', 'protein homooligomerization', 'protein methylation', 'regulation of protein binding']
Protein cereblon
329
Protein cereblon
329
7.6
69
0.19
Q8C7D2Q8C7D2['locomotory exploration behavior', 'negative regulation of ion transmembrane transport', 'negative regulation of large conductance calcium-activated potassium channel activity', 'negative regulation of protein-containing complex assembly', 'positive regulation of protein-containing complex assembly', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination']['locomotory exploration behavior', 'negative regulation of ion transmembrane transport', 'negative regulation of large conductance calcium-activated potassium channel activity', 'negative regulation of protein-containing complex assembly', 'positive regulation of protein-containing complex assembly', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination']
Lysozyme C
127
Lysozyme C
127
7.6
67
0.2
P11375P11375['cytolysis', 'defense response to bacterium', 'metabolic process']['cytolysis', 'defense response to bacterium', 'metabolic process']
Kelch-like protein 11
77
Kelch-like protein 11
77
7.6
70
0.19
Q9NVR0Q9NVR0[][]
Peroxiredoxin-5, mitochondrial
204
Peroxiredoxin-5, mitochondrial
204
7.6
65
0.2
P30044P30044['cell redox homeostasis', 'cellular response to oxidative stress', 'cellular response to reactive oxygen species', 'hydrogen peroxide catabolic process', 'inflammatory response', 'NADPH oxidation', 'negative regulation of apoptotic process', 'negative regulation of oxidoreductase activity', 'negative regulation of transcription by RNA polymerase III', 'positive regulation of collagen biosynthetic process', 'reactive nitrogen species metabolic process', 'regulation of apoptosis involved in tissue homeostasis', 'response to oxidative stress']['cell redox homeostasis', 'cellular response to oxidative stress', 'cellular response to reactive oxygen species', 'hydrogen peroxide catabolic process', 'inflammatory response', 'NADPH oxidation', 'negative regulation of apoptotic process', 'negative regulation of oxidoreductase activity', 'negative regulation of transcription by RNA polymerase III', 'positive regulation of collagen biosynthetic process', 'reactive nitrogen species metabolic process', 'regulation of apoptosis involved in tissue homeostasis', 'response to oxidative stress']
Neutrophil elastase
71
Antileukoproteinase
122
7.6
86
0.15
P08246P03973['acute inflammatory response to antigenic stimulus', 'biosynthetic process of antibacterial peptides active against Gram-negative bacteria', 'cellular calcium ion homeostasis', 'defense response to bacterium', 'extracellular matrix disassembly', 'leukocyte migration involved in inflammatory response', 'negative regulation of chemokine production', 'negative regulation of chemotaxis', 'negative regulation of inflammatory response', 'negative regulation of interleukin-8 production', 'negative regulation of transcription by RNA polymerase II', 'neutrophil-mediated killing of fungus', 'neutrophil-mediated killing of gram-negative bacterium', 'phagocytosis', 'positive regulation of immune response', 'positive regulation of interleukin-8 production', 'positive regulation of leukocyte tethering or rolling', 'positive regulation of MAP kinase activity', 'positive regulation of smooth muscle cell proliferation', 'protein catabolic process', 'proteolysis', 'pyroptosis', 'response to lipopolysaccharide', 'response to UV', 'response to yeast']['antibacterial humoral response', 'immune response', 'innate immune response', 'modulation of process of another organism', 'negative regulation of protein binding', 'negative regulation of viral genome replication', 'response to lipopolysaccharide']
Butyrophilin subfamily 3 member A1
387
Butyrophilin subfamily 3 member A1
387
7.6
72
0.18
O00481O00481['activated T cell proliferation', 'adaptive immune response', 'positive regulation of cytokine production', 'positive regulation of interferon-gamma production', 'regulation of cytokine production', 'T cell receptor signaling pathway']['activated T cell proliferation', 'adaptive immune response', 'positive regulation of cytokine production', 'positive regulation of interferon-gamma production', 'regulation of cytokine production', 'T cell receptor signaling pathway']
Protein numb homolog
160
Protein numb homolog
160
7.6
95
0.14
P49757P49757['adherens junction organization', 'axonogenesis', 'lateral ventricle development', 'negative regulation of protein localization to plasma membrane', 'neuroblast division in subventricular zone', 'positive regulation of cell migration', 'positive regulation of neurogenesis', 'regulation of postsynaptic neurotransmitter receptor internalization']['adherens junction organization', 'axonogenesis', 'lateral ventricle development', 'negative regulation of protein localization to plasma membrane', 'neuroblast division in subventricular zone', 'positive regulation of cell migration', 'positive regulation of neurogenesis', 'regulation of postsynaptic neurotransmitter receptor internalization']
Neurotrophin-4
201
Neurotrophin-4
201
7.6
100
0.13
P34130P34130['adult locomotory behavior', 'epidermis development', 'ganglion mother cell fate determination', 'innervation', 'long-term memory', 'mechanoreceptor differentiation', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of peptidyl-serine phosphorylation', 'regulation of neuron differentiation', 'sensory organ boundary specification', 'taste bud development', 'transmembrane receptor protein tyrosine kinase signaling pathway']['adult locomotory behavior', 'epidermis development', 'ganglion mother cell fate determination', 'innervation', 'long-term memory', 'mechanoreceptor differentiation', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of peptidyl-serine phosphorylation', 'regulation of neuron differentiation', 'sensory organ boundary specification', 'taste bud development', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Serine/threonine-protein kinase 32A
346
Serine/threonine-protein kinase 32A
346
4.2
48
0.5
Q8WU08Q8WU08['intracellular signal transduction', 'peptidyl-serine phosphorylation']['intracellular signal transduction', 'peptidyl-serine phosphorylation']
Ubl carboxyl-terminal hydrolase 18
336
Ubl carboxyl-terminal hydrolase 18
336
4.2
73
0.33
Q9WTV6Q9WTV6['negative regulation of type I interferon-mediated signaling pathway', 'protein deubiquitination', 'regulation of inflammatory response', 'response to bacterium', 'response to stilbenoid', 'ubiquitin-dependent protein catabolic process']['negative regulation of type I interferon-mediated signaling pathway', 'protein deubiquitination', 'regulation of inflammatory response', 'response to bacterium', 'response to stilbenoid', 'ubiquitin-dependent protein catabolic process']
LINE-1 retrotransposable element ORF1 protein
111
LINE-1 retrotransposable element ORF1 protein
111
4.2
63
0.38
Q9UN81Q9UN81['transposition, RNA-mediated']['transposition, RNA-mediated']
C-C motif chemokine 4
34
C-C motif chemokine 4
34
4.2
79
0.3
P13236P13236['cell adhesion', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'eosinophil chemotaxis', 'establishment or maintenance of cell polarity', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'neutrophil chemotaxis', 'positive regulation of calcium ion transport', 'positive regulation of calcium-mediated signaling', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of natural killer cell chemotaxis', 'response to toxic substance', 'response to virus', 'signal transduction']['cell adhesion', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'eosinophil chemotaxis', 'establishment or maintenance of cell polarity', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'neutrophil chemotaxis', 'positive regulation of calcium ion transport', 'positive regulation of calcium-mediated signaling', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of natural killer cell chemotaxis', 'response to toxic substance', 'response to virus', 'signal transduction']
Tyrosine aminotransferase
320
Tyrosine aminotransferase
320
4.2
104
0.23
P17735P17735['2-oxoglutarate metabolic process', 'biosynthetic process', 'glutamate metabolic process', 'L-phenylalanine catabolic process', 'response to dexamethasone', 'response to mercury ion', 'response to oxidative stress', 'tyrosine catabolic process']['2-oxoglutarate metabolic process', 'biosynthetic process', 'glutamate metabolic process', 'L-phenylalanine catabolic process', 'response to dexamethasone', 'response to mercury ion', 'response to oxidative stress', 'tyrosine catabolic process']
Zinc finger MYND domain-containing protein 11
528
Zinc finger MYND domain-containing protein 11
528
4.2
48
0.5
Q15326Q15326['cell cycle', 'chromatin organization', 'defense response to virus', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of JNK cascade', 'negative regulation of transcription, DNA-templated', 'regulation of signal transduction', 'regulation of transcription elongation from RNA polymerase II promoter']['cell cycle', 'chromatin organization', 'defense response to virus', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of JNK cascade', 'negative regulation of transcription, DNA-templated', 'regulation of signal transduction', 'regulation of transcription elongation from RNA polymerase II promoter']
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
119
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
119
4.2
88
0.27
P28907P28907['apoptotic signaling pathway', 'artery smooth muscle contraction', 'B cell proliferation', 'B cell receptor signaling pathway', 'female pregnancy', 'long-term synaptic depression', 'NAD metabolic process', 'negative regulation of apoptotic process', 'negative regulation of bone resorption', 'negative regulation of neuron projection development', 'negative regulation of transcription, DNA-templated', 'positive regulation of B cell proliferation', 'positive regulation of cell growth', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of insulin secretion', 'positive regulation of transcription, DNA-templated', 'positive regulation of vasoconstriction', 'response to estradiol', 'response to hydroperoxide', 'response to hypoxia', 'response to interleukin-1', 'response to progesterone', 'response to retinoic acid', 'response to xenobiotic stimulus', 'signal transduction']['apoptotic signaling pathway', 'artery smooth muscle contraction', 'B cell proliferation', 'B cell receptor signaling pathway', 'female pregnancy', 'long-term synaptic depression', 'NAD metabolic process', 'negative regulation of apoptotic process', 'negative regulation of bone resorption', 'negative regulation of neuron projection development', 'negative regulation of transcription, DNA-templated', 'positive regulation of B cell proliferation', 'positive regulation of cell growth', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of insulin secretion', 'positive regulation of transcription, DNA-templated', 'positive regulation of vasoconstriction', 'response to estradiol', 'response to hydroperoxide', 'response to hypoxia', 'response to interleukin-1', 'response to progesterone', 'response to retinoic acid', 'response to xenobiotic stimulus', 'signal transduction']
Transcription initiation factor IIB
223
Transcription initiation factor IIB
223
4.2
90
0.27
Q00403Q00403['DNA-templated transcription, initiation', 'positive regulation of core promoter binding', 'protein acetylation', 'RNA polymerase II core complex assembly', 'RNA polymerase II preinitiation complex assembly', 'transcription by RNA polymerase II', 'transcription initiation from RNA polymerase II promoter', 'transcriptional start site selection at RNA polymerase II promoter', 'viral transcription']['DNA-templated transcription, initiation', 'positive regulation of core promoter binding', 'protein acetylation', 'RNA polymerase II core complex assembly', 'RNA polymerase II preinitiation complex assembly', 'transcription by RNA polymerase II', 'transcription initiation from RNA polymerase II promoter', 'transcriptional start site selection at RNA polymerase II promoter', 'viral transcription']
Lysozyme C
6
Lysozyme C
6
4.2
72
0.33
P11375P11375['cytolysis', 'defense response to bacterium', 'metabolic process']['cytolysis', 'defense response to bacterium', 'metabolic process']
Cytochrome c
18
Cytochrome c
18
4.2
70
0.34
P99999P99999['activation of cysteine-type endopeptidase activity', 'activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c', 'cellular respiration', 'intrinsic apoptotic signaling pathway', 'mitochondrial electron transport, cytochrome c to oxygen', 'mitochondrial electron transport, ubiquinol to cytochrome c', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process']['activation of cysteine-type endopeptidase activity', 'activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c', 'cellular respiration', 'intrinsic apoptotic signaling pathway', 'mitochondrial electron transport, cytochrome c to oxygen', 'mitochondrial electron transport, ubiquinol to cytochrome c', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process']
Caspase-4
273
Caspase-4
331
4.2
54
0.44
P70343P70343['actin filament organization', 'defense response to bacterium', 'defense response to Gram-positive bacterium', 'ectopic germ cell programmed cell death', 'inflammatory response', 'innate immune response', 'positive regulation of inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-18-mediated signaling pathway', 'positive regulation of macrophage cytokine production', 'protein autoprocessing', 'pyroptosis', 'regulation of apoptotic process', 'regulation of inflammatory response']['actin filament organization', 'defense response to bacterium', 'defense response to Gram-positive bacterium', 'ectopic germ cell programmed cell death', 'inflammatory response', 'innate immune response', 'positive regulation of inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-18-mediated signaling pathway', 'positive regulation of macrophage cytokine production', 'protein autoprocessing', 'pyroptosis', 'regulation of apoptotic process', 'regulation of inflammatory response']
Synaptonemal complex protein 1
183
Synaptonemal complex protein 1
183
4.2
52
0.46
Q15431Q15431['cell division', 'chiasma assembly', 'homologous chromosome pairing at meiosis', 'lateral element assembly', 'meiotic DNA repair synthesis', 'protein homotetramerization', 'reciprocal meiotic recombination', 'regulation of protein localization', 'sperm DNA condensation', 'spermatogenesis', 'synaptonemal complex assembly']['cell division', 'chiasma assembly', 'homologous chromosome pairing at meiosis', 'lateral element assembly', 'meiotic DNA repair synthesis', 'protein homotetramerization', 'reciprocal meiotic recombination', 'regulation of protein localization', 'sperm DNA condensation', 'spermatogenesis', 'synaptonemal complex assembly']
Gremlin-1
141
Gremlin-1
141
4.2
80
0.3
O60565O60565['animal organ morphogenesis', 'apoptotic process', 'cardiac muscle cell differentiation', 'cardiac muscle cell myoblast differentiation', 'cell migration involved in sprouting angiogenesis', 'cell morphogenesis', 'cell-cell signaling', 'collagen fibril organization', 'determination of dorsal identity', 'embryonic limb morphogenesis', 'limb development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'negative regulation of apoptotic process', 'negative regulation of BMP signaling pathway', 'negative regulation of bone mineralization', 'negative regulation of bone mineralization involved in bone maturation', 'negative regulation of bone remodeling', 'negative regulation of bone trabecula formation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell growth', 'negative regulation of chondrocyte differentiation', 'negative regulation of monocyte chemotaxis', 'negative regulation of osteoblast differentiation', 'negative regulation of osteoblast proliferation', 'negative regulation of osteoclast proliferation', 'negative regulation of pathway-restricted SMAD protein phosphorylation', 'negative regulation of transcription, DNA-templated', 'positive regulation of angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell population proliferation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of receptor internalization', 'positive regulation of signaling receptor activity', 'positive regulation of telomerase activity', 'positive regulation of transcription by RNA polymerase II', 'proximal/distal pattern formation', 'regulation of epithelial to mesenchymal transition', 'regulation of focal adhesion assembly', 'sequestering of BMP from receptor via BMP binding', 'signal transduction', 'ureteric bud formation']['animal organ morphogenesis', 'apoptotic process', 'cardiac muscle cell differentiation', 'cardiac muscle cell myoblast differentiation', 'cell migration involved in sprouting angiogenesis', 'cell morphogenesis', 'cell-cell signaling', 'collagen fibril organization', 'determination of dorsal identity', 'embryonic limb morphogenesis', 'limb development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'negative regulation of apoptotic process', 'negative regulation of BMP signaling pathway', 'negative regulation of bone mineralization', 'negative regulation of bone mineralization involved in bone maturation', 'negative regulation of bone remodeling', 'negative regulation of bone trabecula formation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell growth', 'negative regulation of chondrocyte differentiation', 'negative regulation of monocyte chemotaxis', 'negative regulation of osteoblast differentiation', 'negative regulation of osteoblast proliferation', 'negative regulation of osteoclast proliferation', 'negative regulation of pathway-restricted SMAD protein phosphorylation', 'negative regulation of transcription, DNA-templated', 'positive regulation of angiogenesis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell population proliferation', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of peptidyl-tyrosine autophosphorylation', 'positive regulation of receptor internalization', 'positive regulation of signaling receptor activity', 'positive regulation of telomerase activity', 'positive regulation of transcription by RNA polymerase II', 'proximal/distal pattern formation', 'regulation of epithelial to mesenchymal transition', 'regulation of focal adhesion assembly', 'sequestering of BMP from receptor via BMP binding', 'signal transduction', 'ureteric bud formation']
Mitotic spindle assembly checkpoint protein MAD1
633
Mitotic spindle assembly checkpoint protein MAD1
633
4.2
88
0.27
Q9Y6D9Q9Y6D9['attachment of mitotic spindle microtubules to kinetochore', 'cell division', 'cytoplasmic sequestering of protein', 'deactivation of mitotic spindle assembly checkpoint', 'mitotic spindle assembly checkpoint signaling', 'negative regulation of T cell proliferation', 'positive regulation of mitotic cell cycle spindle assembly checkpoint', 'regulation of metaphase plate congression', 'thymus development']['attachment of mitotic spindle microtubules to kinetochore', 'cell division', 'cytoplasmic sequestering of protein', 'deactivation of mitotic spindle assembly checkpoint', 'mitotic spindle assembly checkpoint signaling', 'negative regulation of T cell proliferation', 'positive regulation of mitotic cell cycle spindle assembly checkpoint', 'regulation of metaphase plate congression', 'thymus development']
Cytoglobin
83
Cytoglobin
83
7.3
86
0.16
Q8WWM9Q8WWM9['fatty acid oxidation', 'negative regulation of collagen biosynthetic process', 'negative regulation of fibroblast migration', 'negative regulation of hepatic stellate cell activation', 'oxygen transport', 'response to hypoxia', 'response to oxidative stress']['fatty acid oxidation', 'negative regulation of collagen biosynthetic process', 'negative regulation of fibroblast migration', 'negative regulation of hepatic stellate cell activation', 'oxygen transport', 'response to hypoxia', 'response to oxidative stress']
E3 ubiquitin-protein ligase RNF31
871
E3 ubiquitin-protein ligase RNF31
885
7.3
67
0.2
Q96EP0Q96EP0['CD40 signaling pathway', 'defense response to bacterium', 'negative regulation of necroptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of xenophagy', 'protein linear polyubiquitination', 'protein polyubiquitination', 'T cell receptor signaling pathway']['CD40 signaling pathway', 'defense response to bacterium', 'negative regulation of necroptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of xenophagy', 'protein linear polyubiquitination', 'protein polyubiquitination', 'T cell receptor signaling pathway']
Zinc finger and BTB domain-containing protein 7A
468
Zinc finger and BTB domain-containing protein 7A
387
7.4
74
0.18
O95365O95365['B cell differentiation', 'chromatin organization', 'chromatin remodeling', 'double-strand break repair via classical nonhomologous end joining', 'erythrocyte maturation', 'fat cell differentiation', 'negative regulation of androgen receptor signaling pathway', 'negative regulation of Notch signaling pathway', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'positive regulation of NF-kappaB transcription factor activity', 'protein localization to nucleus', 'regulation of alternative mRNA splicing, via spliceosome', 'regulation of apoptotic process', 'regulation of DNA-binding transcription factor activity', 'regulation of glycolytic process', 'regulation of transcription by RNA polymerase II', 'regulation of transcription regulatory region DNA binding', 'transcription, DNA-templated']['B cell differentiation', 'chromatin organization', 'chromatin remodeling', 'double-strand break repair via classical nonhomologous end joining', 'erythrocyte maturation', 'fat cell differentiation', 'negative regulation of androgen receptor signaling pathway', 'negative regulation of Notch signaling pathway', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'positive regulation of NF-kappaB transcription factor activity', 'protein localization to nucleus', 'regulation of alternative mRNA splicing, via spliceosome', 'regulation of apoptotic process', 'regulation of DNA-binding transcription factor activity', 'regulation of glycolytic process', 'regulation of transcription by RNA polymerase II', 'regulation of transcription regulatory region DNA binding', 'transcription, DNA-templated']
E3 ubiquitin-protein ligase MIB1
286
E3 ubiquitin-protein ligase MIB1
286
7.3
84
0.16
Q86YT6Q86YT6['blood vessel development', 'endocytosis', 'heart looping', 'in utero embryonic development', 'negative regulation of neuron differentiation', 'neural tube formation', 'neuron differentiation', 'Notch signaling pathway', 'positive regulation of endocytosis', 'protein ubiquitination', 'somitogenesis', 'ubiquitin-dependent protein catabolic process']['blood vessel development', 'endocytosis', 'heart looping', 'in utero embryonic development', 'negative regulation of neuron differentiation', 'neural tube formation', 'neuron differentiation', 'Notch signaling pathway', 'positive regulation of endocytosis', 'protein ubiquitination', 'somitogenesis', 'ubiquitin-dependent protein catabolic process']
ATP-dependent RNA helicase DHX58
559
ATP-dependent RNA helicase DHX58
559
7.5
64
0.21
Q96C10Q96C10['cytoplasmic pattern recognition receptor signaling pathway in response to virus', 'innate immune response', 'negative regulation of innate immune response', 'negative regulation of MDA-5 signaling pathway', 'negative regulation of RIG-I signaling pathway', 'negative regulation of type I interferon production', 'positive regulation of interferon-beta production', 'positive regulation of MDA-5 signaling pathway', 'positive regulation of RIG-I signaling pathway', 'positive regulation of type I interferon production', 'regulation of innate immune response', 'response to bacterium', 'response to virus']['cytoplasmic pattern recognition receptor signaling pathway in response to virus', 'innate immune response', 'negative regulation of innate immune response', 'negative regulation of MDA-5 signaling pathway', 'negative regulation of RIG-I signaling pathway', 'negative regulation of type I interferon production', 'positive regulation of interferon-beta production', 'positive regulation of MDA-5 signaling pathway', 'positive regulation of RIG-I signaling pathway', 'positive regulation of type I interferon production', 'regulation of innate immune response', 'response to bacterium', 'response to virus']
Gamma-interferon-inducible lysosomal thiol reductase
145
Gamma-interferon-inducible lysosomal thiol reductase
145
7.3
77
0.18
Q9ESY9Q9ESY9['antigen processing and presentation of exogenous peptide antigen via MHC class I', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'negative regulation of fibroblast proliferation', 'protein stabilization']['antigen processing and presentation of exogenous peptide antigen via MHC class I', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'negative regulation of fibroblast proliferation', 'protein stabilization']
Zinc finger MYND domain-containing protein 11
535
Zinc finger MYND domain-containing protein 11
535
7.3
43
0.32
Q15326Q15326['cell cycle', 'chromatin organization', 'defense response to virus', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of JNK cascade', 'negative regulation of transcription, DNA-templated', 'regulation of signal transduction', 'regulation of transcription elongation from RNA polymerase II promoter']['cell cycle', 'chromatin organization', 'defense response to virus', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of JNK cascade', 'negative regulation of transcription, DNA-templated', 'regulation of signal transduction', 'regulation of transcription elongation from RNA polymerase II promoter']
Kallikrein-7
239
Kallikrein-7
137
7.3
72
0.19
P49862P49862['epidermis development', 'extracellular matrix disassembly', 'positive regulation of antibacterial peptide production', 'proteolysis']['epidermis development', 'extracellular matrix disassembly', 'positive regulation of antibacterial peptide production', 'proteolysis']
E3 ubiquitin-protein ligase RNF8
456
E3 ubiquitin-protein ligase RNF8
456
7.4
75
0.18
O76064O76064['cell cycle', 'cell division', 'cellular response to DNA damage stimulus', 'double-strand break repair', 'double-strand break repair via nonhomologous end joining', 'histone exchange', 'histone H2A K63-linked ubiquitination', 'histone H2A ubiquitination', 'histone H2B ubiquitination', 'interstrand cross-link repair', 'isotype switching', 'negative regulation of transcription elongation from RNA polymerase II promoter', 'positive regulation of DNA repair', 'protein autoubiquitination', 'protein K48-linked ubiquitination', 'protein K63-linked ubiquitination', 'protein ubiquitination', 'response to ionizing radiation', 'spermatid development', 'spermatogenesis, exchange of chromosomal proteins', 'ubiquitin-dependent protein catabolic process']['cell cycle', 'cell division', 'cellular response to DNA damage stimulus', 'double-strand break repair', 'double-strand break repair via nonhomologous end joining', 'histone exchange', 'histone H2A K63-linked ubiquitination', 'histone H2A ubiquitination', 'histone H2B ubiquitination', 'interstrand cross-link repair', 'isotype switching', 'negative regulation of transcription elongation from RNA polymerase II promoter', 'positive regulation of DNA repair', 'protein autoubiquitination', 'protein K48-linked ubiquitination', 'protein K63-linked ubiquitination', 'protein ubiquitination', 'response to ionizing radiation', 'spermatid development', 'spermatogenesis, exchange of chromosomal proteins', 'ubiquitin-dependent protein catabolic process']
Kinesin-like protein KIF2C
310
Kinesin-like protein KIF2C
245
7.6
77
0.17
Q99661Q99661['attachment of mitotic spindle microtubules to kinetochore', 'cell division', 'establishment or maintenance of microtubule cytoskeleton polarity', 'metaphase plate congression', 'microtubule depolymerization', 'microtubule-based movement', 'mitotic metaphase plate congression', 'regulation of chromosome segregation']['attachment of mitotic spindle microtubules to kinetochore', 'cell division', 'establishment or maintenance of microtubule cytoskeleton polarity', 'metaphase plate congression', 'microtubule depolymerization', 'microtubule-based movement', 'mitotic metaphase plate congression', 'regulation of chromosome segregation']
Ras and EF-hand domain-containing protein
20
Ras and EF-hand domain-containing protein
20
7.7
78
0.17
Q8IZ41Q8IZ41[][]
Sequestosome-1
145
Sequestosome-1
145
7.5
43
0.31
Q13501Q13501['aggrephagy', 'apoptotic process', 'autophagy', 'autophagy of mitochondrion', 'brown fat cell proliferation', 'cell differentiation', 'endosomal transport', 'endosome organization', 'energy homeostasis', 'immune system process', 'intracellular signal transduction', 'macroautophagy', 'mitophagy', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of apoptotic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'protein import into nucleus', 'protein localization', 'protein localization to perinuclear region of cytoplasm', 'protein phosphorylation', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of mitochondrion organization', 'regulation of protein complex stability', 'regulation of Ras protein signal transduction', 'response to ischemia', 'response to mitochondrial depolarisation', 'selective autophagy', 'temperature homeostasis', 'transcription by RNA polymerase II', 'ubiquitin-dependent protein catabolic process']['aggrephagy', 'apoptotic process', 'autophagy', 'autophagy of mitochondrion', 'brown fat cell proliferation', 'cell differentiation', 'endosomal transport', 'endosome organization', 'energy homeostasis', 'immune system process', 'intracellular signal transduction', 'macroautophagy', 'mitophagy', 'negative regulation of protein ubiquitination', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of apoptotic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'protein import into nucleus', 'protein localization', 'protein localization to perinuclear region of cytoplasm', 'protein phosphorylation', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of mitochondrion organization', 'regulation of protein complex stability', 'regulation of Ras protein signal transduction', 'response to ischemia', 'response to mitochondrial depolarisation', 'selective autophagy', 'temperature homeostasis', 'transcription by RNA polymerase II', 'ubiquitin-dependent protein catabolic process']
Tumor necrosis factor receptor superfamily member 9
77
Tumor necrosis factor receptor superfamily member 9
44
7.7
87
0.15
P20334P20334['apoptotic process', 'negative regulation of cell population proliferation', 'regulation of cell population proliferation', 'regulation of immature T cell proliferation in thymus']['apoptotic process', 'negative regulation of cell population proliferation', 'regulation of cell population proliferation', 'regulation of immature T cell proliferation in thymus']
Calpain-2 catalytic subunit
191
Calpain-2 catalytic subunit
191
7.5
76
0.18
Q07009Q07009['behavioral response to pain', 'blastocyst development', 'cellular response to amino acid stimulus', 'cellular response to interferon-beta', 'cellular response to lipopolysaccharide', 'female pregnancy', 'myoblast fusion', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of myoblast fusion', 'positive regulation of neuron death', 'positive regulation of phosphatidylcholine biosynthetic process', 'protein autoprocessing', 'protein catabolic process', 'proteolysis', 'proteolysis involved in protein catabolic process', 'regulation of cytoskeleton organization', 'regulation of interleukin-6 production', 'response to hydrogen peroxide', 'response to hypoxia', 'response to mechanical stimulus']['behavioral response to pain', 'blastocyst development', 'cellular response to amino acid stimulus', 'cellular response to interferon-beta', 'cellular response to lipopolysaccharide', 'female pregnancy', 'myoblast fusion', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of myoblast fusion', 'positive regulation of neuron death', 'positive regulation of phosphatidylcholine biosynthetic process', 'protein autoprocessing', 'protein catabolic process', 'proteolysis', 'proteolysis involved in protein catabolic process', 'regulation of cytoskeleton organization', 'regulation of interleukin-6 production', 'response to hydrogen peroxide', 'response to hypoxia', 'response to mechanical stimulus']
Enhancer of mRNA-decapping protein 3
311
Enhancer of mRNA-decapping protein 3
311
7.6
86
0.15
Q96F86Q96F86['deadenylation-independent decapping of nuclear-transcribed mRNA', 'P-body assembly']['deadenylation-independent decapping of nuclear-transcribed mRNA', 'P-body assembly']
Dual specificity protein phosphatase 16
81
Dual specificity protein phosphatase 16
81
4.4
68
0.33
Q9BY84Q9BY84['dephosphorylation', 'MAPK export from nucleus', 'negative regulation of JUN kinase activity', 'negative regulation of MAPK cascade', 'protein dephosphorylation']['dephosphorylation', 'MAPK export from nucleus', 'negative regulation of JUN kinase activity', 'negative regulation of MAPK cascade', 'protein dephosphorylation']
Brain-specific angiogenesis inhibitor 1-associated protein 2
230
Brain-specific angiogenesis inhibitor 1-associated protein 2
202
4.4
67
0.34
Q9UQB8Q9UQB8['actin crosslink formation', 'actin filament bundle assembly', 'axonogenesis', 'brain development', 'cellular response to epidermal growth factor stimulus', 'cellular response to L-glutamate', 'dendrite development', 'insulin receptor signaling pathway', 'modification of synaptic structure, modulating synaptic transmission', 'plasma membrane organization', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of actin filament polymerization', 'positive regulation of dendritic spine morphogenesis', 'positive regulation of excitatory postsynaptic potential', 'protein localization to synapse', 'regulation of actin cytoskeleton organization', 'regulation of cell shape', 'regulation of modification of postsynaptic actin cytoskeleton', 'regulation of synaptic plasticity', 'response to bacterium']['actin crosslink formation', 'actin filament bundle assembly', 'axonogenesis', 'brain development', 'cellular response to epidermal growth factor stimulus', 'cellular response to L-glutamate', 'dendrite development', 'insulin receptor signaling pathway', 'modification of synaptic structure, modulating synaptic transmission', 'plasma membrane organization', 'positive regulation of actin cytoskeleton reorganization', 'positive regulation of actin filament polymerization', 'positive regulation of dendritic spine morphogenesis', 'positive regulation of excitatory postsynaptic potential', 'protein localization to synapse', 'regulation of actin cytoskeleton organization', 'regulation of cell shape', 'regulation of modification of postsynaptic actin cytoskeleton', 'regulation of synaptic plasticity', 'response to bacterium']
cGMP-dependent protein kinase 2
240
cGMP-dependent protein kinase 2
240
4.4
53
0.42
Q13237Q13237['negative regulation of chloride transport', 'negative regulation of chondrocyte proliferation', 'peptidyl-serine autophosphorylation', 'protein localization to plasma membrane', 'protein phosphorylation', 'regulation of chondrocyte differentiation', 'signal transduction', 'tetrahydrobiopterin metabolic process']['negative regulation of chloride transport', 'negative regulation of chondrocyte proliferation', 'peptidyl-serine autophosphorylation', 'protein localization to plasma membrane', 'protein phosphorylation', 'regulation of chondrocyte differentiation', 'signal transduction', 'tetrahydrobiopterin metabolic process']
ATP-binding cassette sub-family G member 8
425
ATP-binding cassette sub-family G member 8
425
4.4
59
0.38
Q9H221Q9H221['bile acid signaling pathway', 'cholesterol efflux', 'cholesterol homeostasis', 'intestinal cholesterol absorption', 'negative regulation of intestinal cholesterol absorption', 'negative regulation of intestinal phytosterol absorption', 'phospholipid transport', 'response to muscle activity', 'response to nutrient', 'response to xenobiotic stimulus', 'sterol transport', 'transmembrane transport', 'triglyceride homeostasis']['bile acid signaling pathway', 'cholesterol efflux', 'cholesterol homeostasis', 'intestinal cholesterol absorption', 'negative regulation of intestinal cholesterol absorption', 'negative regulation of intestinal phytosterol absorption', 'phospholipid transport', 'response to muscle activity', 'response to nutrient', 'response to xenobiotic stimulus', 'sterol transport', 'transmembrane transport', 'triglyceride homeostasis']
MHC class II HLA-DQ-alpha chain
11
HLA class II histocompatibility antigen, DQ beta 1 chain
47
4.4
96
0.24
Q30066Q5SU54['adaptive immune response', 'antigen processing and presentation of peptide or polysaccharide antigen via MHC class II']['adaptive immune response', 'antigen processing and presentation of peptide or polysaccharide antigen via MHC class II']
Integrin beta-2
33
Integrin beta-2
467
4.3
73
0.32
P05107P05107['amyloid-beta clearance', 'apoptotic process', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-cell adhesion', 'cell-cell adhesion via plasma-membrane adhesion molecules', 'cell-cell signaling', 'cell-matrix adhesion', 'cellular response to low-density lipoprotein particle stimulus', 'endodermal cell differentiation', 'heterotypic cell-cell adhesion', 'inflammatory response', 'integrin-mediated signaling pathway', 'leukocyte cell-cell adhesion', 'microglial cell activation', 'negative regulation of dopamine metabolic process', 'neutrophil chemotaxis', 'neutrophil migration', 'phagocytosis, engulfment', 'positive regulation of leukocyte adhesion to vascular endothelial cell', 'positive regulation of neuron death', 'positive regulation of neutrophil degranulation', 'positive regulation of prostaglandin-E synthase activity', 'positive regulation of protein targeting to membrane', 'positive regulation of superoxide anion generation', 'receptor clustering', 'receptor internalization', 'receptor-mediated endocytosis', 'regulation of cell shape', 'regulation of peptidyl-tyrosine phosphorylation']['amyloid-beta clearance', 'apoptotic process', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-cell adhesion', 'cell-cell adhesion via plasma-membrane adhesion molecules', 'cell-cell signaling', 'cell-matrix adhesion', 'cellular response to low-density lipoprotein particle stimulus', 'endodermal cell differentiation', 'heterotypic cell-cell adhesion', 'inflammatory response', 'integrin-mediated signaling pathway', 'leukocyte cell-cell adhesion', 'microglial cell activation', 'negative regulation of dopamine metabolic process', 'neutrophil chemotaxis', 'neutrophil migration', 'phagocytosis, engulfment', 'positive regulation of leukocyte adhesion to vascular endothelial cell', 'positive regulation of neuron death', 'positive regulation of neutrophil degranulation', 'positive regulation of prostaglandin-E synthase activity', 'positive regulation of protein targeting to membrane', 'positive regulation of superoxide anion generation', 'receptor clustering', 'receptor internalization', 'receptor-mediated endocytosis', 'regulation of cell shape', 'regulation of peptidyl-tyrosine phosphorylation']
Dopamine beta-hydroxylase
528
Dopamine beta-hydroxylase
528
4.4
42
0.55
P09172P09172['behavioral response to ethanol', 'blood vessel remodeling', 'chemical synaptic transmission', 'dopamine catabolic process', 'fear response', 'glucose homeostasis', 'homoiothermy', 'leukocyte mediated immunity', 'leukocyte migration', 'locomotory behavior', 'maternal behavior', 'memory', 'norepinephrine biosynthetic process', 'octopamine biosynthetic process', 'positive regulation of cold-induced thermogenesis', 'positive regulation of vasoconstriction', 'regulation of extrinsic apoptotic signaling pathway', 'regulation of vascular associated smooth muscle cell proliferation', 'regulation of vascular endothelial cell proliferation', 'response to amphetamine', 'response to pain', 'vasoconstriction', 'visual learning']['behavioral response to ethanol', 'blood vessel remodeling', 'chemical synaptic transmission', 'dopamine catabolic process', 'fear response', 'glucose homeostasis', 'homoiothermy', 'leukocyte mediated immunity', 'leukocyte migration', 'locomotory behavior', 'maternal behavior', 'memory', 'norepinephrine biosynthetic process', 'octopamine biosynthetic process', 'positive regulation of cold-induced thermogenesis', 'positive regulation of vasoconstriction', 'regulation of extrinsic apoptotic signaling pathway', 'regulation of vascular associated smooth muscle cell proliferation', 'regulation of vascular endothelial cell proliferation', 'response to amphetamine', 'response to pain', 'vasoconstriction', 'visual learning']
ATP-dependent RNA helicase DDX25
398
ATP-dependent RNA helicase DDX25
398
4.3
81
0.28
Q9UHL0Q9UHL0['mRNA export from nucleus', 'poly(A)+ mRNA export from nucleus', 'regulation of translation', 'spermatid development']['mRNA export from nucleus', 'poly(A)+ mRNA export from nucleus', 'regulation of translation', 'spermatid development']
3-ketoacyl-CoA thiolase, mitochondrial
128
3-ketoacyl-CoA thiolase, mitochondrial
128
4.3
79
0.29
P42765P42765['cellular response to hypoxia', 'cholesterol biosynthetic process', 'fatty acid beta-oxidation', 'negative regulation of mitochondrial membrane permeability involved in apoptotic process', 'negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway']['cellular response to hypoxia', 'cholesterol biosynthetic process', 'fatty acid beta-oxidation', 'negative regulation of mitochondrial membrane permeability involved in apoptotic process', 'negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway']
Antizyme inhibitor 1
358
Antizyme inhibitor 1
114
4.3
74
0.31
O35484O35484['negative regulation of protein catabolic process', 'polyamine metabolic process', 'positive regulation of centrosome duplication', 'positive regulation of epithelial cell proliferation', 'positive regulation of polyamine transmembrane transport', 'putrescine biosynthetic process from ornithine']['negative regulation of protein catabolic process', 'polyamine metabolic process', 'positive regulation of centrosome duplication', 'positive regulation of epithelial cell proliferation', 'positive regulation of polyamine transmembrane transport', 'putrescine biosynthetic process from ornithine']
Palmitoyltransferase ZDHHC20
263
Palmitoyltransferase ZDHHC20
263
4.3
56
0.42
Q5W0Z9Q5W0Z9['peptidyl-L-cysteine S-palmitoylation', 'protein palmitoylation', 'protein targeting to membrane']['peptidyl-L-cysteine S-palmitoylation', 'protein palmitoylation', 'protein targeting to membrane']
Thymidylate synthase
174
Thymidylate synthase
174
4.3
88
0.27
P45352P45352['aging', 'cartilage development', 'circadian rhythm', 'developmental growth', 'dTMP biosynthetic process', 'dTTP biosynthetic process', 'intestinal epithelial cell maturation', 'liver regeneration', 'methylation', 'modulation by virus of host process', 'negative regulation of translation', 'pyrimidine nucleobase metabolic process', 'regulation of translation', 'response to cytokine', 'response to ethanol', 'response to folic acid', 'response to glucocorticoid', 'response to organic cyclic compound', 'response to organophosphorus', 'response to progesterone', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'tetrahydrofolate interconversion', 'tetrahydrofolate metabolic process', 'uracil metabolic process']['aging', 'cartilage development', 'circadian rhythm', 'developmental growth', 'dTMP biosynthetic process', 'dTTP biosynthetic process', 'intestinal epithelial cell maturation', 'liver regeneration', 'methylation', 'modulation by virus of host process', 'negative regulation of translation', 'pyrimidine nucleobase metabolic process', 'regulation of translation', 'response to cytokine', 'response to ethanol', 'response to folic acid', 'response to glucocorticoid', 'response to organic cyclic compound', 'response to organophosphorus', 'response to progesterone', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'tetrahydrofolate interconversion', 'tetrahydrofolate metabolic process', 'uracil metabolic process']
Early endosome antigen 1
1299
Early endosome antigen 1
1299
4.2
54
0.44
Q15075Q15075['early endosome to late endosome transport', 'endocytosis', 'modulation by host of viral process', 'synaptic vesicle to endosome fusion', 'vesicle fusion']['early endosome to late endosome transport', 'endocytosis', 'modulation by host of viral process', 'synaptic vesicle to endosome fusion', 'vesicle fusion']
Medulloblastoma antigen MU-MB-50.72
96
Medulloblastoma antigen MU-MB-50.72
96
4.2
67
0.35
Q7Z5E2Q7Z5E2[][]
Potassium voltage-gated channel subfamily D member 3
110
Potassium voltage-gated channel subfamily D member 3
132
3.9
62
0.41
Q62897Q62897['cellular response to BMP stimulus', 'membrane repolarization', 'membrane repolarization during ventricular cardiac muscle cell action potential', 'potassium ion export across plasma membrane', 'potassium ion import across plasma membrane', 'potassium ion transmembrane transport', 'potassium ion transport', 'protein homooligomerization', 'regulation of heart rate by cardiac conduction', 'regulation of ion transmembrane transport', 'ventricular cardiac muscle cell membrane repolarization']['cellular response to BMP stimulus', 'membrane repolarization', 'membrane repolarization during ventricular cardiac muscle cell action potential', 'potassium ion export across plasma membrane', 'potassium ion import across plasma membrane', 'potassium ion transmembrane transport', 'potassium ion transport', 'protein homooligomerization', 'regulation of heart rate by cardiac conduction', 'regulation of ion transmembrane transport', 'ventricular cardiac muscle cell membrane repolarization']
Cytosolic iron-sulfur assembly component 2A
90
Cytosolic iron-sulfur assembly component 2A
90
3.9
74
0.35
Q9H5X1Q9H5X1['chromosome segregation', 'iron-sulfur cluster assembly', 'protein maturation by [4Fe-4S] cluster transfer', 'protein maturation by iron-sulfur cluster transfer']['chromosome segregation', 'iron-sulfur cluster assembly', 'protein maturation by [4Fe-4S] cluster transfer', 'protein maturation by iron-sulfur cluster transfer']
Protein fem-1 homolog B
186
Folliculin-interacting protein 1
610
3.9
69
0.38
Q9Z2G0Q68FD7['apoptotic process', 'branching involved in prostate gland morphogenesis', 'epithelial cell maturation', 'epithelial cell maturation involved in prostate gland development', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein ubiquitination', 'regulation of DNA damage checkpoint', 'regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'regulation of ubiquitin-protein transferase activity', 'ubiquitin-dependent protein catabolic process via the C-end degron rule pathway']['B cell apoptotic process', 'cellular response to starvation', 'immature B cell differentiation', 'negative regulation of cell population proliferation', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of TOR signaling', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of B cell apoptotic process', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex assembly', 'positive regulation of TOR signaling', 'regulation of pro-B cell differentiation', 'regulation of protein phosphorylation', 'TOR signaling']
Bcl-2-related protein A1
55
Phorbol-12-myristate-13-acetate-induced protein 1
25
3.9
60
0.43
Q16548Q13794['extrinsic apoptotic signaling pathway in absence of ligand', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of apoptotic process']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'apoptotic process', 'cellular response to DNA damage stimulus', 'cellular response to glucose starvation', 'cellular response to hypoxia', 'defense response to virus', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway by p53 class mediator', 'negative regulation of mitochondrial membrane potential', 'positive regulation of apoptotic process', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of DNA damage response, signal transduction by p53 class mediator', 'positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway', 'positive regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'positive regulation of glucose metabolic process', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of release of cytochrome c from mitochondria', 'proteasomal protein catabolic process', 'reactive oxygen species metabolic process', 'regulation of mitochondrial membrane permeability', 'release of cytochrome c from mitochondria', 'response to dsRNA', 'T cell homeostasis']
Kelch-like ECH-associated protein 1
489
Kelch-like ECH-associated protein 1
434
4.1
76
0.32
Q14145Q14145['cellular response to interleukin-4', 'cellular response to oxidative stress', 'cytoplasmic sequestering of transcription factor', 'in utero embryonic development', 'negative regulation of DNA-binding transcription factor activity', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'protein ubiquitination', 'regulation of autophagy', 'regulation of epidermal cell differentiation', 'ubiquitin-dependent protein catabolic process']['cellular response to interleukin-4', 'cellular response to oxidative stress', 'cytoplasmic sequestering of transcription factor', 'in utero embryonic development', 'negative regulation of DNA-binding transcription factor activity', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'protein ubiquitination', 'regulation of autophagy', 'regulation of epidermal cell differentiation', 'ubiquitin-dependent protein catabolic process']
Protein lin-9 homolog
122
Protein lin-37 homolog
119
4.1
86
0.29
Q5TKA1Q96GY3['cell cycle', 'DNA biosynthetic process', 'regulation of cell cycle', 'regulation of transcription by RNA polymerase II', 'reproduction', 'transcription, DNA-templated']['negative regulation of transcription by RNA polymerase II']
Thymidylate synthase
174
Thymidylate synthase
174
4.1
93
0.26
Q544L2Q544L2['aging', 'cartilage development', 'circadian rhythm', 'developmental growth', 'dTMP biosynthetic process', 'dTTP biosynthetic process', 'intestinal epithelial cell maturation', 'liver regeneration', 'methylation', 'response to cytokine', 'response to ethanol', 'response to folic acid', 'response to glucocorticoid', 'response to organophosphorus', 'response to progesterone', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'tetrahydrofolate interconversion', 'uracil metabolic process']['aging', 'cartilage development', 'circadian rhythm', 'developmental growth', 'dTMP biosynthetic process', 'dTTP biosynthetic process', 'intestinal epithelial cell maturation', 'liver regeneration', 'methylation', 'response to cytokine', 'response to ethanol', 'response to folic acid', 'response to glucocorticoid', 'response to organophosphorus', 'response to progesterone', 'response to toxic substance', 'response to vitamin A', 'response to xenobiotic stimulus', 'tetrahydrofolate interconversion', 'uracil metabolic process']
Myosin-7
905
Myosin-7
905
4.0
55
0.45
P12883P12883['adult heart development', 'ATP metabolic process', 'cardiac muscle contraction', 'cardiac muscle hypertrophy in response to stress', 'muscle contraction', 'muscle filament sliding', 'regulation of heart rate', 'regulation of slow-twitch skeletal muscle fiber contraction', 'regulation of the force of heart contraction', 'regulation of the force of skeletal muscle contraction', 'sarcomere organization', 'skeletal muscle contraction', 'striated muscle contraction', 'transition between fast and slow fiber', 'ventricular cardiac muscle tissue morphogenesis']['adult heart development', 'ATP metabolic process', 'cardiac muscle contraction', 'cardiac muscle hypertrophy in response to stress', 'muscle contraction', 'muscle filament sliding', 'regulation of heart rate', 'regulation of slow-twitch skeletal muscle fiber contraction', 'regulation of the force of heart contraction', 'regulation of the force of skeletal muscle contraction', 'sarcomere organization', 'skeletal muscle contraction', 'striated muscle contraction', 'transition between fast and slow fiber', 'ventricular cardiac muscle tissue morphogenesis']
Glutathione S-transferase P
99
Glutathione S-transferase P
99
4.5
44
0.5
P80031P80031['glutathione derivative biosynthetic process', 'glutathione metabolic process', 'hepoxilin biosynthetic process', 'prostaglandin metabolic process']['glutathione derivative biosynthetic process', 'glutathione metabolic process', 'hepoxilin biosynthetic process', 'prostaglandin metabolic process']
Muskelin
180
Muskelin
180
4.5
52
0.43
Q99PV3Q99PV3['actin cytoskeleton reorganization', 'cell-matrix adhesion', 'regulation of cell shape', 'regulation of receptor internalization']['actin cytoskeleton reorganization', 'cell-matrix adhesion', 'regulation of cell shape', 'regulation of receptor internalization']
Potassium voltage-gated channel subfamily D member 3
132
Potassium voltage-gated channel subfamily D member 3
110
4.5
66
0.34
Q9UK17Q9UK17['membrane repolarization', 'membrane repolarization during cardiac muscle cell action potential', 'membrane repolarization during ventricular cardiac muscle cell action potential', 'potassium ion export across plasma membrane', 'potassium ion transmembrane transport', 'potassium ion transport', 'protein homooligomerization', 'regulation of heart rate by cardiac conduction', 'regulation of ion transmembrane transport', 'ventricular cardiac muscle cell membrane repolarization']['membrane repolarization', 'membrane repolarization during cardiac muscle cell action potential', 'membrane repolarization during ventricular cardiac muscle cell action potential', 'potassium ion export across plasma membrane', 'potassium ion transmembrane transport', 'potassium ion transport', 'protein homooligomerization', 'regulation of heart rate by cardiac conduction', 'regulation of ion transmembrane transport', 'ventricular cardiac muscle cell membrane repolarization']
Mothers against decapentaplegic homolog 7
278
Mothers against decapentaplegic homolog 7
278
4.6
88
0.25
O35253O35253['adherens junction assembly', 'anatomical structure morphogenesis', 'artery morphogenesis', 'BMP signaling pathway', 'cell differentiation', 'cellular response to leukemia inhibitory factor', 'cellular response to transforming growth factor beta stimulus', 'intracellular signal transduction', 'negative regulation of BMP signaling pathway', 'negative regulation of chondrocyte proliferation', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of ossification', 'negative regulation of pathway-restricted SMAD protein phosphorylation', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of peptidyl-threonine phosphorylation', 'negative regulation of protein ubiquitination', 'negative regulation of T cell cytokine production', 'negative regulation of T-helper 17 cell differentiation', 'negative regulation of T-helper 17 type immune response', 'negative regulation of transcription by competitive promoter binding', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of ubiquitin-protein transferase activity', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of cell-cell adhesion', 'positive regulation of chondrocyte hypertrophy', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of protein ubiquitination', 'protein stabilization', 'protein-containing complex localization', 'regulation of activin receptor signaling pathway', 'regulation of cardiac muscle contraction', 'regulation of epithelial to mesenchymal transition', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulation of ventricular cardiac muscle cell membrane depolarization', 'response to laminar fluid shear stress', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'ureteric bud development', 'ventricular cardiac muscle tissue morphogenesis', 'ventricular septum morphogenesis']['adherens junction assembly', 'anatomical structure morphogenesis', 'artery morphogenesis', 'BMP signaling pathway', 'cell differentiation', 'cellular response to leukemia inhibitory factor', 'cellular response to transforming growth factor beta stimulus', 'intracellular signal transduction', 'negative regulation of BMP signaling pathway', 'negative regulation of chondrocyte proliferation', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of ossification', 'negative regulation of pathway-restricted SMAD protein phosphorylation', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of peptidyl-threonine phosphorylation', 'negative regulation of protein ubiquitination', 'negative regulation of T cell cytokine production', 'negative regulation of T-helper 17 cell differentiation', 'negative regulation of T-helper 17 type immune response', 'negative regulation of transcription by competitive promoter binding', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of ubiquitin-protein transferase activity', 'pathway-restricted SMAD protein phosphorylation', 'positive regulation of cell-cell adhesion', 'positive regulation of chondrocyte hypertrophy', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of protein ubiquitination', 'protein stabilization', 'protein-containing complex localization', 'regulation of activin receptor signaling pathway', 'regulation of cardiac muscle contraction', 'regulation of epithelial to mesenchymal transition', 'regulation of transforming growth factor beta receptor signaling pathway', 'regulation of ventricular cardiac muscle cell membrane depolarization', 'response to laminar fluid shear stress', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'ureteric bud development', 'ventricular cardiac muscle tissue morphogenesis', 'ventricular septum morphogenesis']
E3 ubiquitin-protein ligase UHRF2
704
E3 ubiquitin-protein ligase UHRF2
704
4.5
56
0.4
Q96PU4Q96PU4['cell cycle', 'cell differentiation', 'maintenance of DNA methylation', 'protein autoubiquitination', 'protein ubiquitination', 'regulation of cell cycle']['cell cycle', 'cell differentiation', 'maintenance of DNA methylation', 'protein autoubiquitination', 'protein ubiquitination', 'regulation of cell cycle']
C-C motif chemokine 13
34
C-C motif chemokine 13
34
4.7
74
0.29
Q99616Q99616['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytoskeleton organization', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'regulation of cell shape', 'signal transduction']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytoskeleton organization', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'regulation of cell shape', 'signal transduction']
Medulloblastoma antigen MU-MB-50.72
100
Medulloblastoma antigen MU-MB-50.72
100
4.5
52
0.42
Q7Z5E2Q7Z5E2[][]
NKG2-D type II integral membrane protein
121
NKG2-D type II integral membrane protein
121
6.6
89
0.17
O54709O54709['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of apoptotic process', 'positive regulation of interferon-gamma production', 'positive regulation of myeloid dendritic cell activation', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target', 'positive regulation of nitric oxide biosynthetic process', 'stimulatory C-type lectin receptor signaling pathway']['adaptive immune response', 'cell differentiation', 'cellular response to lipopolysaccharide', 'defense response to Gram-positive bacterium', 'natural killer cell activation', 'natural killer cell mediated cytotoxicity', 'negative regulation of GTPase activity', 'negative regulation of natural killer cell chemotaxis', 'nitric oxide biosynthetic process', 'positive regulation of apoptotic process', 'positive regulation of interferon-gamma production', 'positive regulation of myeloid dendritic cell activation', 'positive regulation of natural killer cell mediated cytotoxicity', 'positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target', 'positive regulation of nitric oxide biosynthetic process', 'stimulatory C-type lectin receptor signaling pathway']
Actin, alpha skeletal muscle
376
Thymosin beta-4
nan
1.7
nan
nan
P68135P20065['actin filament bundle assembly', 'actin filament polymerization', 'mesenchyme migration', 'positive regulation of gene expression', 'skeletal muscle fiber development', 'skeletal muscle thin filament assembly']['actin filament organization', 'negative regulation of cell cycle G1/S phase transition', 'negative regulation of hematopoietic stem cell differentiation', 'positive regulation of smooth muscle cell differentiation', 'positive regulation of smooth muscle cell migration', 'positive regulation of transcription, DNA-templated', 'regulation of cell migration', 'sequestering of actin monomers']
Synaptonemal complex protein 1
190
Synaptonemal complex protein 1
190
3.5
51
0.57
Q15431Q15431['cell division', 'chiasma assembly', 'homologous chromosome pairing at meiosis', 'lateral element assembly', 'meiotic DNA repair synthesis', 'protein homotetramerization', 'reciprocal meiotic recombination', 'regulation of protein localization', 'sperm DNA condensation', 'spermatogenesis', 'synaptonemal complex assembly']['cell division', 'chiasma assembly', 'homologous chromosome pairing at meiosis', 'lateral element assembly', 'meiotic DNA repair synthesis', 'protein homotetramerization', 'reciprocal meiotic recombination', 'regulation of protein localization', 'sperm DNA condensation', 'spermatogenesis', 'synaptonemal complex assembly']
NAD-dependent protein deacetylase sirtuin-1
380
NAD-dependent protein deacetylase sirtuin-1
380
3.5
74
0.39
Q96EB6Q96EB6['angiogenesis', 'behavioral response to starvation', 'cellular glucose homeostasis', 'cellular response to DNA damage stimulus', 'cellular response to glucose starvation', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to ionizing radiation', 'cellular response to leukemia inhibitory factor', 'cellular response to starvation', 'cellular response to tumor necrosis factor', 'cellular triglyceride homeostasis', 'cholesterol homeostasis', 'chromatin organization', 'circadian regulation of gene expression', 'DNA methylation-dependent heterochromatin assembly', 'DNA synthesis involved in DNA repair', 'energy homeostasis', 'fatty acid homeostasis', 'heterochromatin assembly', 'histone deacetylation', 'histone H3 deacetylation', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'leptin-mediated signaling pathway', 'macrophage differentiation', 'muscle organ development', 'negative regulation of androgen receptor signaling pathway', 'negative regulation of apoptotic process', 'negative regulation of cAMP-dependent protein kinase activity', 'negative regulation of cell cycle', 'negative regulation of cell growth', 'negative regulation of cellular response to testosterone stimulus', 'negative regulation of cellular senescence', 'negative regulation of DNA damage response, signal transduction by p53 class mediator', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of helicase activity', 'negative regulation of histone H3-K14 acetylation', 'negative regulation of histone H3-K9 trimethylation', 'negative regulation of histone H4-K16 acetylation', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'negative regulation of neuron death', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of peptidyl-lysine acetylation', 'negative regulation of phosphorylation', 'negative regulation of prostaglandin biosynthetic process', 'negative regulation of protein acetylation', 'negative regulation of protein kinase B signaling', 'negative regulation of TOR signaling', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'ovulation from ovarian follicle', 'peptidyl-lysine acetylation', 'peptidyl-lysine deacetylation', 'positive regulation of adaptive immune response', 'positive regulation of adipose tissue development', 'positive regulation of angiogenesis', 'positive regulation of apoptotic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of cAMP-dependent protein kinase activity', 'positive regulation of cell population proliferation', 'positive regulation of cellular senescence', 'positive regulation of cholesterol efflux', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of DNA repair', 'positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway', 'positive regulation of endothelial cell proliferation', 'positive regulation of gluconeogenesis', 'positive regulation of histone deacetylation', 'positive regulation of histone H3-K9 methylation', 'positive regulation of histone methylation', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of macroautophagy', 'positive regulation of macrophage apoptotic process', 'positive regulation of macrophage cytokine production', 'positive regulation of MHC class II biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'positive regulation of smooth muscle cell differentiation', 'positive regulation of transcription by RNA polymerase II', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein deacetylation', 'protein depropionylation', 'protein destabilization', 'protein ubiquitination', 'pyrimidine dimer repair by nucleotide-excision repair', 'rDNA heterochromatin assembly', 'regulation of apoptotic process', 'regulation of bile acid biosynthetic process', 'regulation of brown fat cell differentiation', 'regulation of cell population proliferation', 'regulation of cellular response to heat', 'regulation of centrosome duplication', 'regulation of endodeoxyribonuclease activity', 'regulation of glucose metabolic process', 'regulation of lipid storage', 'regulation of mitotic cell cycle', 'regulation of peroxisome proliferator activated receptor signaling pathway', 'regulation of protein serine/threonine kinase activity', 'regulation of smooth muscle cell apoptotic process', 'regulation of transcription by glucose', 'response to hydrogen peroxide', 'response to insulin', 'response to leptin', 'response to oxidative stress', 'single strand break repair', 'spermatogenesis', 'stress-induced premature senescence', 'transforming growth factor beta receptor signaling pathway', 'triglyceride mobilization', 'UV-damage excision repair', 'white fat cell differentiation']['angiogenesis', 'behavioral response to starvation', 'cellular glucose homeostasis', 'cellular response to DNA damage stimulus', 'cellular response to glucose starvation', 'cellular response to hydrogen peroxide', 'cellular response to hypoxia', 'cellular response to ionizing radiation', 'cellular response to leukemia inhibitory factor', 'cellular response to starvation', 'cellular response to tumor necrosis factor', 'cellular triglyceride homeostasis', 'cholesterol homeostasis', 'chromatin organization', 'circadian regulation of gene expression', 'DNA methylation-dependent heterochromatin assembly', 'DNA synthesis involved in DNA repair', 'energy homeostasis', 'fatty acid homeostasis', 'heterochromatin assembly', 'histone deacetylation', 'histone H3 deacetylation', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'leptin-mediated signaling pathway', 'macrophage differentiation', 'muscle organ development', 'negative regulation of androgen receptor signaling pathway', 'negative regulation of apoptotic process', 'negative regulation of cAMP-dependent protein kinase activity', 'negative regulation of cell cycle', 'negative regulation of cell growth', 'negative regulation of cellular response to testosterone stimulus', 'negative regulation of cellular senescence', 'negative regulation of DNA damage response, signal transduction by p53 class mediator', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of helicase activity', 'negative regulation of histone H3-K14 acetylation', 'negative regulation of histone H3-K9 trimethylation', 'negative regulation of histone H4-K16 acetylation', 'negative regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'negative regulation of neuron death', 'negative regulation of NF-kappaB transcription factor activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of peptidyl-lysine acetylation', 'negative regulation of phosphorylation', 'negative regulation of prostaglandin biosynthetic process', 'negative regulation of protein acetylation', 'negative regulation of protein kinase B signaling', 'negative regulation of TOR signaling', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'ovulation from ovarian follicle', 'peptidyl-lysine acetylation', 'peptidyl-lysine deacetylation', 'positive regulation of adaptive immune response', 'positive regulation of adipose tissue development', 'positive regulation of angiogenesis', 'positive regulation of apoptotic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of cAMP-dependent protein kinase activity', 'positive regulation of cell population proliferation', 'positive regulation of cellular senescence', 'positive regulation of cholesterol efflux', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of DNA repair', 'positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway', 'positive regulation of endothelial cell proliferation', 'positive regulation of gluconeogenesis', 'positive regulation of histone deacetylation', 'positive regulation of histone H3-K9 methylation', 'positive regulation of histone methylation', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of macroautophagy', 'positive regulation of macrophage apoptotic process', 'positive regulation of macrophage cytokine production', 'positive regulation of MHC class II biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'positive regulation of smooth muscle cell differentiation', 'positive regulation of transcription by RNA polymerase II', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein deacetylation', 'protein depropionylation', 'protein destabilization', 'protein ubiquitination', 'pyrimidine dimer repair by nucleotide-excision repair', 'rDNA heterochromatin assembly', 'regulation of apoptotic process', 'regulation of bile acid biosynthetic process', 'regulation of brown fat cell differentiation', 'regulation of cell population proliferation', 'regulation of cellular response to heat', 'regulation of centrosome duplication', 'regulation of endodeoxyribonuclease activity', 'regulation of glucose metabolic process', 'regulation of lipid storage', 'regulation of mitotic cell cycle', 'regulation of peroxisome proliferator activated receptor signaling pathway', 'regulation of protein serine/threonine kinase activity', 'regulation of smooth muscle cell apoptotic process', 'regulation of transcription by glucose', 'response to hydrogen peroxide', 'response to insulin', 'response to leptin', 'response to oxidative stress', 'single strand break repair', 'spermatogenesis', 'stress-induced premature senescence', 'transforming growth factor beta receptor signaling pathway', 'triglyceride mobilization', 'UV-damage excision repair', 'white fat cell differentiation']
Hepatocyte growth factor
129
Hepatocyte growth factor
129
3.5
82
0.35
Q08048Q08048['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'proteolysis', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']['animal organ regeneration', 'cell chemotaxis', 'cell morphogenesis', 'cellular response to hepatocyte growth factor stimulus', 'epithelial cell proliferation', 'hepatocyte growth factor receptor signaling pathway', 'liver development', 'myoblast proliferation', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors', 'negative regulation of hydrogen peroxide-mediated programmed cell death', 'negative regulation of inflammatory response', 'negative regulation of interleukin-6 production', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of release of cytochrome c from mitochondria', 'positive regulation of angiogenesis', 'positive regulation of cell migration', 'positive regulation of DNA biosynthetic process', 'positive regulation of interleukin-10 production', 'positive regulation of MAPK cascade', 'positive regulation of myelination', 'positive regulation of neuron projection regeneration', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein phosphorylation', 'proteolysis', 'regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling', 'regulation of p38MAPK cascade', 'regulation of tau-protein kinase activity', 'skeletal muscle cell proliferation']
Growth factor receptor-bound protein 7
526
Growth factor receptor-bound protein 7
527
2.0
79
0.63
Q14451Q14451['epidermal growth factor receptor signaling pathway', 'negative regulation of translation', 'positive regulation of cell migration', 'stress granule assembly']['epidermal growth factor receptor signaling pathway', 'negative regulation of translation', 'positive regulation of cell migration', 'stress granule assembly']
Cytidine deaminase
59
Cytidine deaminase
65
3.5
93
0.31
P56389P56389['cellular response to external biotic stimulus', 'CMP catabolic process', 'cytidine deamination', 'dCMP catabolic process', 'negative regulation of cell growth', 'negative regulation of nucleotide metabolic process', 'response to cycloheximide', 'UMP salvage']['cellular response to external biotic stimulus', 'CMP catabolic process', 'cytidine deamination', 'dCMP catabolic process', 'negative regulation of cell growth', 'negative regulation of nucleotide metabolic process', 'response to cycloheximide', 'UMP salvage']
Macrophage colony-stimulating factor 1
63
Macrophage colony-stimulating factor 1
63
2.0
56
0.89
Q3U395Q3U395['branching involved in mammary gland duct morphogenesis', 'cell population proliferation', 'developmental process involved in reproduction', 'homeostasis of number of cells within a tissue', 'inflammatory response', 'innate immune response', 'macrophage colony-stimulating factor signaling pathway', 'macrophage differentiation', 'macrophage homeostasis', 'mammary duct terminal end bud growth', 'mammary gland fat development', 'microglial cell proliferation', 'monocyte differentiation', 'monocyte homeostasis', 'myeloid leukocyte migration', 'negative regulation of neuron death', 'neutrophil homeostasis', 'odontogenesis', 'ossification', 'osteoclast differentiation', 'osteoclast proliferation', 'positive regulation of cell population proliferation', 'positive regulation of cell-matrix adhesion', 'positive regulation of gene expression', 'positive regulation of leukocyte migration', 'positive regulation of macrophage chemotaxis', 'positive regulation of macrophage colony-stimulating factor signaling pathway', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of macrophage differentiation', 'positive regulation of macrophage migration', 'positive regulation of microglial cell migration', 'positive regulation of monocyte differentiation', 'positive regulation of mononuclear cell proliferation', 'positive regulation of multicellular organism growth', 'positive regulation of odontogenesis of dentin-containing tooth', 'positive regulation of osteoclast differentiation', 'positive regulation of protein kinase activity', 'positive regulation of protein metabolic process', 'positive regulation of Ras protein signal transduction', 'Ras protein signal transduction', 'regulation of ossification', 'response to ischemia', 'transmembrane receptor protein tyrosine kinase signaling pathway']['branching involved in mammary gland duct morphogenesis', 'cell population proliferation', 'developmental process involved in reproduction', 'homeostasis of number of cells within a tissue', 'inflammatory response', 'innate immune response', 'macrophage colony-stimulating factor signaling pathway', 'macrophage differentiation', 'macrophage homeostasis', 'mammary duct terminal end bud growth', 'mammary gland fat development', 'microglial cell proliferation', 'monocyte differentiation', 'monocyte homeostasis', 'myeloid leukocyte migration', 'negative regulation of neuron death', 'neutrophil homeostasis', 'odontogenesis', 'ossification', 'osteoclast differentiation', 'osteoclast proliferation', 'positive regulation of cell population proliferation', 'positive regulation of cell-matrix adhesion', 'positive regulation of gene expression', 'positive regulation of leukocyte migration', 'positive regulation of macrophage chemotaxis', 'positive regulation of macrophage colony-stimulating factor signaling pathway', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of macrophage differentiation', 'positive regulation of macrophage migration', 'positive regulation of microglial cell migration', 'positive regulation of monocyte differentiation', 'positive regulation of mononuclear cell proliferation', 'positive regulation of multicellular organism growth', 'positive regulation of odontogenesis of dentin-containing tooth', 'positive regulation of osteoclast differentiation', 'positive regulation of protein kinase activity', 'positive regulation of protein metabolic process', 'positive regulation of Ras protein signal transduction', 'Ras protein signal transduction', 'regulation of ossification', 'response to ischemia', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Dystrophin
433
Dystrophin
433
2.0
61
0.82
P11532P11532['actin cytoskeleton organization', 'cardiac muscle cell action potential', 'cardiac muscle contraction', 'maintenance of blood-brain barrier', 'motile cilium assembly', 'muscle cell cellular homeostasis', 'muscle cell development', 'muscle organ development', 'negative regulation of peptidyl-cysteine S-nitrosylation', 'negative regulation of peptidyl-serine phosphorylation', 'neuron development', 'peptide biosynthetic process', 'positive regulation of neuron differentiation', 'positive regulation of neuron projection development', 'positive regulation of sodium ion transmembrane transporter activity', 'protein localization', 'protein-containing complex assembly', 'regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion', 'regulation of cellular response to growth factor stimulus', 'regulation of heart rate', 'regulation of muscle system process', 'regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of skeletal muscle contraction', 'regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion', 'regulation of voltage-gated calcium channel activity', 'response to muscle stretch', 'skeletal muscle tissue development']['actin cytoskeleton organization', 'cardiac muscle cell action potential', 'cardiac muscle contraction', 'maintenance of blood-brain barrier', 'motile cilium assembly', 'muscle cell cellular homeostasis', 'muscle cell development', 'muscle organ development', 'negative regulation of peptidyl-cysteine S-nitrosylation', 'negative regulation of peptidyl-serine phosphorylation', 'neuron development', 'peptide biosynthetic process', 'positive regulation of neuron differentiation', 'positive regulation of neuron projection development', 'positive regulation of sodium ion transmembrane transporter activity', 'protein localization', 'protein-containing complex assembly', 'regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion', 'regulation of cellular response to growth factor stimulus', 'regulation of heart rate', 'regulation of muscle system process', 'regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of skeletal muscle contraction', 'regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion', 'regulation of voltage-gated calcium channel activity', 'response to muscle stretch', 'skeletal muscle tissue development']
MHC class II HLA-DQ-alpha chain
11
MHC class II antigen
47
3.4
94
0.31
Q30066Q67AJ6['adaptive immune response', 'antigen processing and presentation of peptide or polysaccharide antigen via MHC class II']['adaptive immune response', 'antigen processing and presentation of peptide or polysaccharide antigen via MHC class II']
Guanine nucleotide-binding protein G(i) subunit alpha-1
214
Guanine nucleotide-binding protein G(i) subunit alpha-1
214
2.0
51
0.97
P10824P10824['adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell cycle', 'cell division', 'cellular response to forskolin', 'G protein-coupled receptor signaling pathway', 'negative regulation of synaptic transmission', 'positive regulation of protein localization to cell cortex', 'regulation of cAMP-mediated signaling', 'regulation of mitotic spindle organization']['adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell cycle', 'cell division', 'cellular response to forskolin', 'G protein-coupled receptor signaling pathway', 'negative regulation of synaptic transmission', 'positive regulation of protein localization to cell cortex', 'regulation of cAMP-mediated signaling', 'regulation of mitotic spindle organization']
E3 SUMO-protein ligase PIAS3
201
E3 SUMO-protein ligase PIAS3
201
3.4
46
0.64
Q9Y6X2Q9Y6X2['negative regulation of gene expression', 'negative regulation of osteoclast differentiation', 'negative regulation of protein sumoylation', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of gene expression', 'positive regulation of membrane potential', 'positive regulation of protein sumoylation', 'protein sumoylation', 'regulation of transcription by RNA polymerase II', 'response to hormone', 'TNFSF11-mediated signaling pathway']['negative regulation of gene expression', 'negative regulation of osteoclast differentiation', 'negative regulation of protein sumoylation', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of gene expression', 'positive regulation of membrane potential', 'positive regulation of protein sumoylation', 'protein sumoylation', 'regulation of transcription by RNA polymerase II', 'response to hormone', 'TNFSF11-mediated signaling pathway']
Pyrroline-5-carboxylate reductase 2
225
Pyrroline-5-carboxylate reductase 2
225
3.5
78
0.36
Q96C36Q96C36['cellular response to oxidative stress', 'L-proline biosynthetic process', 'proline biosynthetic process']['cellular response to oxidative stress', 'L-proline biosynthetic process', 'proline biosynthetic process']
CCA tRNA nucleotidyltransferase 1, mitochondrial
373
CCA tRNA nucleotidyltransferase 1, mitochondrial
373
2.0
71
0.7
Q96Q11Q96Q11['ATP', 'CTP', 'CTP', "mitochondrial tRNA 3'-end processing", "tRNA 3'-end processing", "tRNA 3'-terminal CCA addition", 'tRNA processing']['ATP', 'CTP', 'CTP', "mitochondrial tRNA 3'-end processing", "tRNA 3'-end processing", "tRNA 3'-terminal CCA addition", 'tRNA processing']
Xenotropic and polytropic retrovirus receptor 1
188
Xenotropic and polytropic retrovirus receptor 1
188
2.0
64
0.77
Q9UBH6Q9UBH6['cellular phosphate ion homeostasis', 'cellular response to phosphate starvation', 'G protein-coupled receptor signaling pathway', 'phosphate ion transmembrane transport', 'phosphate ion transport', 'response to virus']['cellular phosphate ion homeostasis', 'cellular response to phosphate starvation', 'G protein-coupled receptor signaling pathway', 'phosphate ion transmembrane transport', 'phosphate ion transport', 'response to virus']
Cytidine deaminase
99
Cytidine deaminase
59
3.4
58
0.52
P32320P32320['cell surface receptor signaling pathway', 'cellular response to external biotic stimulus', 'cytidine deamination', 'cytosine metabolic process', 'negative regulation of cell growth', 'negative regulation of nucleotide metabolic process', 'pyrimidine-containing compound salvage', 'response to cycloheximide', 'UMP salvage']['cell surface receptor signaling pathway', 'cellular response to external biotic stimulus', 'cytidine deamination', 'cytosine metabolic process', 'negative regulation of cell growth', 'negative regulation of nucleotide metabolic process', 'pyrimidine-containing compound salvage', 'response to cycloheximide', 'UMP salvage']
Ighg protein
155
MAb 6H10 light chain
234
2.0
nan
nan
Q569X1A0A0U5BC76[][]
Cyclin-G-associated kinase
87
Cyclin-G-associated kinase
87
2.0
70
0.71
O14976O14976['cell cycle', 'chaperone cofactor-dependent protein refolding', 'clathrin coat disassembly', 'clathrin-coated pit assembly', 'clathrin-dependent endocytosis', 'endoplasmic reticulum organization', 'Golgi organization', 'Golgi to lysosome transport', 'negative regulation of neuron projection development', 'protein localization to Golgi apparatus', 'protein localization to plasma membrane', 'protein phosphorylation', 'receptor-mediated endocytosis', 'synaptic vesicle uncoating']['cell cycle', 'chaperone cofactor-dependent protein refolding', 'clathrin coat disassembly', 'clathrin-coated pit assembly', 'clathrin-dependent endocytosis', 'endoplasmic reticulum organization', 'Golgi organization', 'Golgi to lysosome transport', 'negative regulation of neuron projection development', 'protein localization to Golgi apparatus', 'protein localization to plasma membrane', 'protein phosphorylation', 'receptor-mediated endocytosis', 'synaptic vesicle uncoating']
Mitogen-activated protein kinase kinase kinase 8
222
Mitogen-activated protein kinase kinase kinase 8
222
3.3
66
0.46
P41279P41279['cell cycle', 'MAPK cascade', 'protein phosphorylation', 'T cell costimulation']['cell cycle', 'MAPK cascade', 'protein phosphorylation', 'T cell costimulation']
Ketimine reductase mu-crystallin
283
Ketimine reductase mu-crystallin
283
3.4
86
0.34
O54983O54983['mitochondrial transport', 'negative regulation of transcription by RNA polymerase II', 'sensory perception of sound', 'thyroid hormone metabolic process', 'thyroid hormone transport']['mitochondrial transport', 'negative regulation of transcription by RNA polymerase II', 'sensory perception of sound', 'thyroid hormone metabolic process', 'thyroid hormone transport']
Golgi reassembly-stacking protein 2
103
Golgin-45
393
3.7
78
0.34
Q99JX3Q8R2X8['cell differentiation', 'establishment of protein localization to plasma membrane', 'Golgi organization', 'organelle assembly', 'organelle organization', 'response to endoplasmic reticulum stress', 'spermatogenesis']['Golgi organization', 'Golgi to plasma membrane protein transport']
Histone-lysine N-methyltransferase 2C
1060
Histone-lysine N-methyltransferase 2C
1060
3.7
64
0.42
Q8NEZ4Q8NEZ4['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']['chromatin organization', 'histone H3-K4 methylation', 'histone H3-K4 monomethylation', 'positive regulation of transcription by RNA polymerase II']
Tumor necrosis factor receptor superfamily member 16
379
Tumor necrosis factor receptor superfamily member 16
379
2.0
86
0.58
P07174P07174['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'axon guidance', 'cellular glucose homeostasis', 'cellular response to amyloid-beta', 'cellular response to oxidative stress', 'central nervous system development', 'circadian regulation of gene expression', 'circadian rhythm', 'detection of temperature stimulus', 'dorsal aorta development', 'glucose homeostasis', 'hair follicle morphogenesis', 'intracellular protein transport', 'negative regulation of angiogenesis', 'negative regulation of apoptotic process', 'negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'negative regulation of cell migration', 'negative regulation of dendritic spine development', 'negative regulation of fibroblast growth factor receptor signaling pathway', 'negative regulation of hair follicle development', 'negative regulation of mitochondrial depolarization', 'negative regulation of neuron apoptotic process', 'negative regulation of neuron projection development', 'nerve development', 'neuron apoptotic process', 'positive regulation of apoptotic process', 'positive regulation of apoptotic signaling pathway', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of fibroblast proliferation', 'positive regulation of MAPK cascade', 'positive regulation of miRNA transcription', 'positive regulation of myelination', 'positive regulation of neural precursor cell proliferation', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of neuron projection development', 'positive regulation of odontogenesis of dentin-containing tooth', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of Rho protein signal transduction', 'positive regulation of synaptic transmission, cholinergic', 'positive regulation of synaptic transmission, glutamatergic', 'regulation of cell death', 'regulation of gene expression', 'regulation of reactive oxygen species metabolic process', 'response to lipopolysaccharide', 'response to wounding', 'Rho protein signal transduction', 'sensory perception of pain', 'signal transduction', 'skeletal muscle cell differentiation', 'skin development']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'axon guidance', 'cellular glucose homeostasis', 'cellular response to amyloid-beta', 'cellular response to oxidative stress', 'central nervous system development', 'circadian regulation of gene expression', 'circadian rhythm', 'detection of temperature stimulus', 'dorsal aorta development', 'glucose homeostasis', 'hair follicle morphogenesis', 'intracellular protein transport', 'negative regulation of angiogenesis', 'negative regulation of apoptotic process', 'negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'negative regulation of cell migration', 'negative regulation of dendritic spine development', 'negative regulation of fibroblast growth factor receptor signaling pathway', 'negative regulation of hair follicle development', 'negative regulation of mitochondrial depolarization', 'negative regulation of neuron apoptotic process', 'negative regulation of neuron projection development', 'nerve development', 'neuron apoptotic process', 'positive regulation of apoptotic process', 'positive regulation of apoptotic signaling pathway', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of fibroblast proliferation', 'positive regulation of MAPK cascade', 'positive regulation of miRNA transcription', 'positive regulation of myelination', 'positive regulation of neural precursor cell proliferation', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of neuron projection development', 'positive regulation of odontogenesis of dentin-containing tooth', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of Rho protein signal transduction', 'positive regulation of synaptic transmission, cholinergic', 'positive regulation of synaptic transmission, glutamatergic', 'regulation of cell death', 'regulation of gene expression', 'regulation of reactive oxygen species metabolic process', 'response to lipopolysaccharide', 'response to wounding', 'Rho protein signal transduction', 'sensory perception of pain', 'signal transduction', 'skeletal muscle cell differentiation', 'skin development']
Urokinase plasminogen activator surface receptor
46
Urokinase plasminogen activator surface receptor
98
3.7
64
0.42
Q03405Q03405['blood coagulation', 'chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'negative regulation of intrinsic apoptotic signaling pathway', 'positive regulation of DNA binding', 'positive regulation of epidermal growth factor receptor signaling pathway', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of protein phosphorylation', 'positive regulation of release of cytochrome c from mitochondria', 'regulation of cell adhesion', 'regulation of fibrinolysis', 'regulation of plasminogen activation', 'regulation of proteolysis', 'signal transduction', 'urokinase plasminogen activator signaling pathway']['blood coagulation', 'chemotaxis', 'negative regulation of apoptotic process', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway', 'negative regulation of intrinsic apoptotic signaling pathway', 'positive regulation of DNA binding', 'positive regulation of epidermal growth factor receptor signaling pathway', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of protein phosphorylation', 'positive regulation of release of cytochrome c from mitochondria', 'regulation of cell adhesion', 'regulation of fibrinolysis', 'regulation of plasminogen activation', 'regulation of proteolysis', 'signal transduction', 'urokinase plasminogen activator signaling pathway']
DNA repair protein RAD50
684
DNA repair protein RAD50
681
3.5
67
0.43
Q92878Q92878['cellular response to DNA damage stimulus', 'chromosome organization involved in meiotic cell cycle', 'DNA double-strand break processing', 'DNA duplex unwinding', 'DNA recombination', 'DNA repair', 'DNA strand resection involved in replication fork processing', 'double-strand break repair', 'homologous recombination', 'mitotic G2/M transition checkpoint', 'negative regulation of telomere capping', 'nucleic acid phosphodiester bond hydrolysis', 'positive regulation of kinase activity', 'positive regulation of protein autophosphorylation', 'positive regulation of telomere maintenance', 'reciprocal meiotic recombination', 'regulation of mitotic recombination', 'telomere maintenance', 'telomere maintenance via recombination', 'telomere maintenance via telomerase', "telomeric 3' overhang formation"]['cellular response to DNA damage stimulus', 'chromosome organization involved in meiotic cell cycle', 'DNA double-strand break processing', 'DNA duplex unwinding', 'DNA recombination', 'DNA repair', 'DNA strand resection involved in replication fork processing', 'double-strand break repair', 'homologous recombination', 'mitotic G2/M transition checkpoint', 'negative regulation of telomere capping', 'nucleic acid phosphodiester bond hydrolysis', 'positive regulation of kinase activity', 'positive regulation of protein autophosphorylation', 'positive regulation of telomere maintenance', 'reciprocal meiotic recombination', 'regulation of mitotic recombination', 'telomere maintenance', 'telomere maintenance via recombination', 'telomere maintenance via telomerase', "telomeric 3' overhang formation"]
Beta-2-microglobulin
45
Beta-2-microglobulin
100
2.0
80
0.63
P61769P61769['amyloid fibril formation', 'antibacterial humoral response', 'antigen processing and presentation of endogenous peptide antigen via MHC class I', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to iron ion', 'cellular response to iron(III) ion', 'cellular response to lipopolysaccharide', 'cellular response to nicotine', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'iron ion homeostasis', 'iron ion transport', 'learning or memory', 'negative regulation of epithelial cell proliferation', 'negative regulation of forebrain neuron differentiation', 'negative regulation of neurogenesis', 'negative regulation of neuron projection development', 'negative regulation of receptor binding', 'peptide antigen assembly with MHC class II protein complex', 'positive regulation of cellular senescence', 'positive regulation of ferrous iron binding', 'positive regulation of protein binding', 'positive regulation of receptor binding', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of T cell activation', 'positive regulation of T cell cytokine production', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of transferrin receptor binding', 'protein homotetramerization', 'protein refolding', 'regulation of erythrocyte differentiation', 'regulation of iron ion transport', 'regulation of membrane depolarization', 'response to molecule of bacterial origin', 'retina homeostasis', 'sensory perception of smell', 'T cell differentiation in thymus', 'T cell mediated cytotoxicity']['amyloid fibril formation', 'antibacterial humoral response', 'antigen processing and presentation of endogenous peptide antigen via MHC class I', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to iron ion', 'cellular response to iron(III) ion', 'cellular response to lipopolysaccharide', 'cellular response to nicotine', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'iron ion homeostasis', 'iron ion transport', 'learning or memory', 'negative regulation of epithelial cell proliferation', 'negative regulation of forebrain neuron differentiation', 'negative regulation of neurogenesis', 'negative regulation of neuron projection development', 'negative regulation of receptor binding', 'peptide antigen assembly with MHC class II protein complex', 'positive regulation of cellular senescence', 'positive regulation of ferrous iron binding', 'positive regulation of protein binding', 'positive regulation of receptor binding', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of T cell activation', 'positive regulation of T cell cytokine production', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of transferrin receptor binding', 'protein homotetramerization', 'protein refolding', 'regulation of erythrocyte differentiation', 'regulation of iron ion transport', 'regulation of membrane depolarization', 'response to molecule of bacterial origin', 'retina homeostasis', 'sensory perception of smell', 'T cell differentiation in thymus', 'T cell mediated cytotoxicity']
Potassium voltage-gated channel subfamily D member 3
131
Potassium voltage-gated channel subfamily D member 3
110
3.8
69
0.39
Q9UK17Q9UK17['membrane repolarization', 'membrane repolarization during cardiac muscle cell action potential', 'membrane repolarization during ventricular cardiac muscle cell action potential', 'potassium ion export across plasma membrane', 'potassium ion transmembrane transport', 'potassium ion transport', 'protein homooligomerization', 'regulation of heart rate by cardiac conduction', 'regulation of ion transmembrane transport', 'ventricular cardiac muscle cell membrane repolarization']['membrane repolarization', 'membrane repolarization during cardiac muscle cell action potential', 'membrane repolarization during ventricular cardiac muscle cell action potential', 'potassium ion export across plasma membrane', 'potassium ion transmembrane transport', 'potassium ion transport', 'protein homooligomerization', 'regulation of heart rate by cardiac conduction', 'regulation of ion transmembrane transport', 'ventricular cardiac muscle cell membrane repolarization']
F-box/WD repeat-containing protein 1A
137
F-box/WD repeat-containing protein 1A
137
3.5
64
0.44
Q9Y297Q9Y297['branching involved in mammary gland duct morphogenesis', 'cellular response to organic cyclic compound', 'mammary gland epithelial cell proliferation', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of smoothened signaling pathway', 'negative regulation of transcription, DNA-templated', 'positive regulation of circadian rhythm', 'positive regulation of proteolysis', 'positive regulation of transcription, DNA-templated', 'positive regulation of ubiquitin protein ligase activity', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein dephosphorylation', 'protein destabilization', 'protein K48-linked ubiquitination', 'protein polyubiquitination', 'protein ubiquitination', 'regulation of canonical Wnt signaling pathway', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of proteasomal protein catabolic process', 'rhythmic process', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process', 'signal transduction', 'ubiquitin-dependent protein catabolic process', 'Wnt signaling pathway']['branching involved in mammary gland duct morphogenesis', 'cellular response to organic cyclic compound', 'mammary gland epithelial cell proliferation', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of smoothened signaling pathway', 'negative regulation of transcription, DNA-templated', 'positive regulation of circadian rhythm', 'positive regulation of proteolysis', 'positive regulation of transcription, DNA-templated', 'positive regulation of ubiquitin protein ligase activity', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein dephosphorylation', 'protein destabilization', 'protein K48-linked ubiquitination', 'protein polyubiquitination', 'protein ubiquitination', 'regulation of canonical Wnt signaling pathway', 'regulation of cell cycle', 'regulation of circadian rhythm', 'regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of proteasomal protein catabolic process', 'rhythmic process', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process', 'signal transduction', 'ubiquitin-dependent protein catabolic process', 'Wnt signaling pathway']
Plexin-B2
1508
Plexin-B2
1508
3.6
34
0.83
B2RXS4B2RXS4['brain development', 'excitatory synapse assembly', 'homophilic cell adhesion via plasma membrane adhesion molecules', 'negative regulation of cell adhesion', 'neural tube closure', 'neuroblast proliferation', 'positive regulation of axonogenesis', 'positive regulation of neuron projection development', 'positive regulation of translation', 'regulation of cell migration', 'regulation of cell shape', 'regulation of GTPase activity', 'regulation of neuron migration', 'regulation of protein phosphorylation', 'semaphorin-plexin signaling pathway', 'semaphorin-plexin signaling pathway involved in axon guidance']['brain development', 'excitatory synapse assembly', 'homophilic cell adhesion via plasma membrane adhesion molecules', 'negative regulation of cell adhesion', 'neural tube closure', 'neuroblast proliferation', 'positive regulation of axonogenesis', 'positive regulation of neuron projection development', 'positive regulation of translation', 'regulation of cell migration', 'regulation of cell shape', 'regulation of GTPase activity', 'regulation of neuron migration', 'regulation of protein phosphorylation', 'semaphorin-plexin signaling pathway', 'semaphorin-plexin signaling pathway involved in axon guidance']
DNA repair protein RAD50
684
DNA repair protein RAD50
684
3.6
64
0.44
Q92878Q92878['cellular response to DNA damage stimulus', 'chromosome organization involved in meiotic cell cycle', 'DNA double-strand break processing', 'DNA duplex unwinding', 'DNA recombination', 'DNA repair', 'DNA strand resection involved in replication fork processing', 'double-strand break repair', 'homologous recombination', 'mitotic G2/M transition checkpoint', 'negative regulation of telomere capping', 'nucleic acid phosphodiester bond hydrolysis', 'positive regulation of kinase activity', 'positive regulation of protein autophosphorylation', 'positive regulation of telomere maintenance', 'reciprocal meiotic recombination', 'regulation of mitotic recombination', 'telomere maintenance', 'telomere maintenance via recombination', 'telomere maintenance via telomerase', "telomeric 3' overhang formation"]['cellular response to DNA damage stimulus', 'chromosome organization involved in meiotic cell cycle', 'DNA double-strand break processing', 'DNA duplex unwinding', 'DNA recombination', 'DNA repair', 'DNA strand resection involved in replication fork processing', 'double-strand break repair', 'homologous recombination', 'mitotic G2/M transition checkpoint', 'negative regulation of telomere capping', 'nucleic acid phosphodiester bond hydrolysis', 'positive regulation of kinase activity', 'positive regulation of protein autophosphorylation', 'positive regulation of telomere maintenance', 'reciprocal meiotic recombination', 'regulation of mitotic recombination', 'telomere maintenance', 'telomere maintenance via recombination', 'telomere maintenance via telomerase', "telomeric 3' overhang formation"]
Kelch-like protein 3
526
Kelch-like protein 3
549
2.0
85
0.59
Q9UH77Q9UH77['distal tubule morphogenesis', 'gene expression', 'ion homeostasis', 'potassium ion homeostasis', 'protein K48-linked ubiquitination', 'protein phosphorylation', 'protein ubiquitination', 'renal sodium ion absorption', 'selective autophagy', 'ubiquitin-dependent protein catabolic process']['distal tubule morphogenesis', 'gene expression', 'ion homeostasis', 'potassium ion homeostasis', 'protein K48-linked ubiquitination', 'protein phosphorylation', 'protein ubiquitination', 'renal sodium ion absorption', 'selective autophagy', 'ubiquitin-dependent protein catabolic process']
Dual specificity protein phosphatase 5
251
Dual specificity protein phosphatase 5
251
3.6
63
0.44
Q16690Q16690['dephosphorylation', 'endoderm formation', 'ERK1 and ERK2 cascade', 'MAPK cascade', 'negative regulation of MAPK cascade', 'peptidyl-threonine dephosphorylation', 'peptidyl-tyrosine dephosphorylation', 'protein dephosphorylation']['dephosphorylation', 'endoderm formation', 'ERK1 and ERK2 cascade', 'MAPK cascade', 'negative regulation of MAPK cascade', 'peptidyl-threonine dephosphorylation', 'peptidyl-tyrosine dephosphorylation', 'protein dephosphorylation']
Cytidine deaminase
59
Cytidine deaminase
65
3.6
74
0.38
P32320P32320['cell surface receptor signaling pathway', 'cellular response to external biotic stimulus', 'cytidine deamination', 'cytosine metabolic process', 'negative regulation of cell growth', 'negative regulation of nucleotide metabolic process', 'pyrimidine-containing compound salvage', 'response to cycloheximide', 'UMP salvage']['cell surface receptor signaling pathway', 'cellular response to external biotic stimulus', 'cytidine deamination', 'cytosine metabolic process', 'negative regulation of cell growth', 'negative regulation of nucleotide metabolic process', 'pyrimidine-containing compound salvage', 'response to cycloheximide', 'UMP salvage']
Protein polybromo-1
450
Protein polybromo-1
450
2.0
66
0.76
Q86U86Q86U86['chromatin remodeling', 'mitotic cell cycle', 'negative regulation of cell population proliferation', 'positive regulation of cell differentiation', 'positive regulation of double-strand break repair', 'positive regulation of myoblast differentiation', 'positive regulation of T cell differentiation', 'regulation of G0 to G1 transition', 'regulation of G1/S transition of mitotic cell cycle', 'regulation of mitotic metaphase/anaphase transition', 'regulation of nucleotide-excision repair', 'regulation of transcription by RNA polymerase II']['chromatin remodeling', 'mitotic cell cycle', 'negative regulation of cell population proliferation', 'positive regulation of cell differentiation', 'positive regulation of double-strand break repair', 'positive regulation of myoblast differentiation', 'positive regulation of T cell differentiation', 'regulation of G0 to G1 transition', 'regulation of G1/S transition of mitotic cell cycle', 'regulation of mitotic metaphase/anaphase transition', 'regulation of nucleotide-excision repair', 'regulation of transcription by RNA polymerase II']
SWI/SNF complex subunit SMARCC1
462
SWI/SNF complex subunit SMARCC1
462
3.3
56
0.54
Q92922Q92922['animal organ morphogenesis', 'chromatin remodeling', 'insulin receptor signaling pathway', 'negative regulation of cell differentiation', 'negative regulation of proteasomal ubiquitin-dependent protein catabolic process', 'nervous system development', 'nucleosome disassembly', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of double-strand break repair', 'positive regulation of myoblast differentiation', 'positive regulation of stem cell population maintenance', 'positive regulation of T cell differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of G0 to G1 transition', 'regulation of G1/S transition of mitotic cell cycle', 'regulation of mitotic metaphase/anaphase transition', 'regulation of nucleotide-excision repair', 'regulation of transcription by RNA polymerase II']['animal organ morphogenesis', 'chromatin remodeling', 'insulin receptor signaling pathway', 'negative regulation of cell differentiation', 'negative regulation of proteasomal ubiquitin-dependent protein catabolic process', 'nervous system development', 'nucleosome disassembly', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of double-strand break repair', 'positive regulation of myoblast differentiation', 'positive regulation of stem cell population maintenance', 'positive regulation of T cell differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of G0 to G1 transition', 'regulation of G1/S transition of mitotic cell cycle', 'regulation of mitotic metaphase/anaphase transition', 'regulation of nucleotide-excision repair', 'regulation of transcription by RNA polymerase II']
Coagulation factor X
341
Coagulation factor X
172
2.0
82
0.6
P00743P00743['blood coagulation', 'proteolysis']['blood coagulation', 'proteolysis']
Plexin-B2
1510
Plexin-B2
1510
3.6
44
0.63
B2RXS4B2RXS4['brain development', 'excitatory synapse assembly', 'homophilic cell adhesion via plasma membrane adhesion molecules', 'negative regulation of cell adhesion', 'neural tube closure', 'neuroblast proliferation', 'positive regulation of axonogenesis', 'positive regulation of neuron projection development', 'positive regulation of translation', 'regulation of cell migration', 'regulation of cell shape', 'regulation of GTPase activity', 'regulation of neuron migration', 'regulation of protein phosphorylation', 'semaphorin-plexin signaling pathway', 'semaphorin-plexin signaling pathway involved in axon guidance']['brain development', 'excitatory synapse assembly', 'homophilic cell adhesion via plasma membrane adhesion molecules', 'negative regulation of cell adhesion', 'neural tube closure', 'neuroblast proliferation', 'positive regulation of axonogenesis', 'positive regulation of neuron projection development', 'positive regulation of translation', 'regulation of cell migration', 'regulation of cell shape', 'regulation of GTPase activity', 'regulation of neuron migration', 'regulation of protein phosphorylation', 'semaphorin-plexin signaling pathway', 'semaphorin-plexin signaling pathway involved in axon guidance']
Tumor necrosis factor receptor superfamily member 9
121
Tumor necrosis factor receptor superfamily member 9
121
2.0
70
0.71
Q07011Q07011['apoptotic process', 'negative regulation of cell population proliferation', 'regulation of cell population proliferation', 'regulation of immature T cell proliferation in thymus']['apoptotic process', 'negative regulation of cell population proliferation', 'regulation of cell population proliferation', 'regulation of immature T cell proliferation in thymus']
ETS domain-containing transcription factor ERF
72
ETS domain-containing transcription factor ERF
72
2.0
39
1.27
P50548P50548['cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'regulation of transcription by RNA polymerase II']['cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'regulation of transcription by RNA polymerase II']
Dipeptidase 1
377
Dipeptidase 1
377
2.0
56
0.88
P16444P16444['antibiotic metabolic process', 'cellular lactam catabolic process', 'cellular response to calcium ion', 'cellular response to nitric oxide', 'cellular response to xenobiotic stimulus', 'glutathione catabolic process', 'glutathione metabolic process', 'homocysteine metabolic process', 'leukotriene D4 catabolic process', 'lipid metabolic process', 'negative regulation of apoptotic process', 'negative regulation of cell migration', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'proteolysis']['antibiotic metabolic process', 'cellular lactam catabolic process', 'cellular response to calcium ion', 'cellular response to nitric oxide', 'cellular response to xenobiotic stimulus', 'glutathione catabolic process', 'glutathione metabolic process', 'homocysteine metabolic process', 'leukotriene D4 catabolic process', 'lipid metabolic process', 'negative regulation of apoptotic process', 'negative regulation of cell migration', 'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'proteolysis']
Protein bicaudal D homolog 2
754
Protein bicaudal D homolog 2
754
3.8
50
0.53
Q8TD16Q8TD16['centrosome localization', 'microtubule anchoring at microtubule organizing center', 'microtubule-based movement', 'minus-end-directed organelle transport along microtubule', 'mRNA transport', 'protein localization to Golgi apparatus', 'protein localization to organelle', 'protein transport', 'regulation of microtubule cytoskeleton organization', 'retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum']['centrosome localization', 'microtubule anchoring at microtubule organizing center', 'microtubule-based movement', 'minus-end-directed organelle transport along microtubule', 'mRNA transport', 'protein localization to Golgi apparatus', 'protein localization to organelle', 'protein transport', 'regulation of microtubule cytoskeleton organization', 'retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum']
DEP domain-containing mTOR-interacting protein
102
DEP domain-containing mTOR-interacting protein
102
2.0
44
1.12
Q8TB45Q8TB45['intracellular signal transduction', 'negative regulation of cell size', 'negative regulation of protein kinase activity', 'negative regulation of TOR signaling', 'negative regulation of TORC1 signaling', 'negative regulation of TORC2 signaling', 'regulation of extrinsic apoptotic signaling pathway']['intracellular signal transduction', 'negative regulation of cell size', 'negative regulation of protein kinase activity', 'negative regulation of TOR signaling', 'negative regulation of TORC1 signaling', 'negative regulation of TORC2 signaling', 'regulation of extrinsic apoptotic signaling pathway']
Immunoglobulin lambda constant 1
105
Immunoglobulin lambda constant 1
105
2.0
29
1.7
P01842P01842['adaptive immune response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
Galectin-1
131
Galectin-1
131
3.8
62
0.43
P16045P16045['apoptotic process', 'cell-cell adhesion', 'heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules', 'myoblast differentiation', 'negative regulation of cell-substrate adhesion', 'negative regulation of neuron projection development', 'plasma cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of erythrocyte aggregation', 'positive regulation of inflammatory response', 'positive regulation of viral entry into host cell', 'T cell costimulation']['apoptotic process', 'cell-cell adhesion', 'heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules', 'myoblast differentiation', 'negative regulation of cell-substrate adhesion', 'negative regulation of neuron projection development', 'plasma cell differentiation', 'positive regulation of apoptotic process', 'positive regulation of erythrocyte aggregation', 'positive regulation of inflammatory response', 'positive regulation of viral entry into host cell', 'T cell costimulation']
Sialoadhesin
36
Sialoadhesin
36
2.0
75
0.66
Q62230Q62230['cell adhesion', 'clathrin-dependent endocytosis of virus by host cell', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of T cell apoptotic process']['cell adhesion', 'clathrin-dependent endocytosis of virus by host cell', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of T cell apoptotic process']
C-C motif chemokine 5
73
C-C motif chemokine 5
33
9.9
75
0.13
P13501P13501['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'chemokine-mediated signaling pathway', 'chemotaxis', 'dendritic cell chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of innate immune response', 'positive regulation of macrophage chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of translational initiation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of viral genome replication', 'protein kinase B signaling', 'regulation of chronic inflammatory response', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to toxic substance', 'response to virus']['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'chemokine-mediated signaling pathway', 'chemotaxis', 'dendritic cell chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of innate immune response', 'positive regulation of macrophage chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of translational initiation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of viral genome replication', 'protein kinase B signaling', 'regulation of chronic inflammatory response', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to toxic substance', 'response to virus']
Cardiac phospholamban
41
Cardiac phospholamban
41
9.7
59
0.18
P61015P61015['adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'cardiac muscle tissue development', 'cellular calcium ion homeostasis', 'muscle cell cellular homeostasis', 'negative regulation of ATPase-coupled calcium transmembrane transporter activity', 'negative regulation of calcium ion binding', 'negative regulation of calcium ion import', 'negative regulation of calcium ion import into sarcoplasmic reticulum', 'negative regulation of calcium ion transmembrane transporter activity', 'negative regulation of catalytic activity', 'negative regulation of heart rate', 'Notch signaling pathway', 'regulation of calcium ion transport', 'regulation of cardiac muscle cell contraction', 'regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion', 'regulation of relaxation of muscle', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of the force of heart contraction by cardiac conduction']['adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'cardiac muscle tissue development', 'cellular calcium ion homeostasis', 'muscle cell cellular homeostasis', 'negative regulation of ATPase-coupled calcium transmembrane transporter activity', 'negative regulation of calcium ion binding', 'negative regulation of calcium ion import', 'negative regulation of calcium ion import into sarcoplasmic reticulum', 'negative regulation of calcium ion transmembrane transporter activity', 'negative regulation of catalytic activity', 'negative regulation of heart rate', 'Notch signaling pathway', 'regulation of calcium ion transport', 'regulation of cardiac muscle cell contraction', 'regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion', 'regulation of relaxation of muscle', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of the force of heart contraction by cardiac conduction']
Cardiac phospholamban
36
Cardiac phospholamban
36
9.7
60
0.17
P61015P61015['adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'cardiac muscle tissue development', 'cellular calcium ion homeostasis', 'muscle cell cellular homeostasis', 'negative regulation of ATPase-coupled calcium transmembrane transporter activity', 'negative regulation of calcium ion binding', 'negative regulation of calcium ion import', 'negative regulation of calcium ion import into sarcoplasmic reticulum', 'negative regulation of calcium ion transmembrane transporter activity', 'negative regulation of catalytic activity', 'negative regulation of heart rate', 'Notch signaling pathway', 'regulation of calcium ion transport', 'regulation of cardiac muscle cell contraction', 'regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion', 'regulation of relaxation of muscle', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of the force of heart contraction by cardiac conduction']['adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'cardiac muscle tissue development', 'cellular calcium ion homeostasis', 'muscle cell cellular homeostasis', 'negative regulation of ATPase-coupled calcium transmembrane transporter activity', 'negative regulation of calcium ion binding', 'negative regulation of calcium ion import', 'negative regulation of calcium ion import into sarcoplasmic reticulum', 'negative regulation of calcium ion transmembrane transporter activity', 'negative regulation of catalytic activity', 'negative regulation of heart rate', 'Notch signaling pathway', 'regulation of calcium ion transport', 'regulation of cardiac muscle cell contraction', 'regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion', 'regulation of relaxation of muscle', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of the force of heart contraction by cardiac conduction']
Cardiac phospholamban
41
Cardiac phospholamban
36
2.7
60
0.63
P61015P61015['adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'cardiac muscle tissue development', 'cellular calcium ion homeostasis', 'muscle cell cellular homeostasis', 'negative regulation of ATPase-coupled calcium transmembrane transporter activity', 'negative regulation of calcium ion binding', 'negative regulation of calcium ion import', 'negative regulation of calcium ion import into sarcoplasmic reticulum', 'negative regulation of calcium ion transmembrane transporter activity', 'negative regulation of catalytic activity', 'negative regulation of heart rate', 'Notch signaling pathway', 'regulation of calcium ion transport', 'regulation of cardiac muscle cell contraction', 'regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion', 'regulation of relaxation of muscle', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of the force of heart contraction by cardiac conduction']['adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'cardiac muscle tissue development', 'cellular calcium ion homeostasis', 'muscle cell cellular homeostasis', 'negative regulation of ATPase-coupled calcium transmembrane transporter activity', 'negative regulation of calcium ion binding', 'negative regulation of calcium ion import', 'negative regulation of calcium ion import into sarcoplasmic reticulum', 'negative regulation of calcium ion transmembrane transporter activity', 'negative regulation of catalytic activity', 'negative regulation of heart rate', 'Notch signaling pathway', 'regulation of calcium ion transport', 'regulation of cardiac muscle cell contraction', 'regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion', 'regulation of relaxation of muscle', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of the force of heart contraction by cardiac conduction']
Thioredoxin
32
DNA-(apurinic or apyrimidinic site) endonuclease
65
2.0
59
0.84
P10599P27695['activation of protein kinase B activity', 'cell redox homeostasis', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of protein export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA binding', 'positive regulation of peptidyl-cysteine S-nitrosylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'response to nitric oxide', 'response to radiation']['aging', 'base-excision repair', 'base-excision repair, gap-filling', 'cell redox homeostasis', 'cellular response to cAMP', 'cellular response to hydrogen peroxide', 'cellular response to peptide hormone stimulus', 'DNA catabolic process, endonucleolytic', 'DNA demethylation', 'DNA recombination', 'DNA repair', 'negative regulation of smooth muscle cell migration', 'positive regulation of G1/S transition of mitotic cell cycle', 'positive regulation of transcription by RNA polymerase II', 'regulation of apoptotic process', 'regulation of mRNA stability', 'response to xenobiotic stimulus', 'telomere maintenance', 'telomere maintenance via base-excision repair']
Cardiac phospholamban
36
Cardiac phospholamban
36
8.8
64
0.18
P26678P26678['adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'blood circulation', 'cardiac muscle tissue development', 'muscle cell cellular homeostasis', 'negative regulation of ATP-dependent activity', 'negative regulation of ATPase-coupled calcium transmembrane transporter activity', 'negative regulation of calcium ion binding', 'negative regulation of calcium ion import', 'negative regulation of calcium ion import into sarcoplasmic reticulum', 'negative regulation of calcium ion transmembrane transporter activity', 'negative regulation of calcium ion transport', 'negative regulation of catalytic activity', 'negative regulation of heart rate', 'Notch signaling pathway', 'regulation of ATPase-coupled calcium transmembrane transporter activity', 'regulation of calcium ion transport', 'regulation of cardiac muscle cell contraction', 'regulation of cardiac muscle cell membrane potential', 'regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion', 'regulation of cytosolic calcium ion concentration', 'regulation of heart contraction', 'regulation of relaxation of cardiac muscle', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of the force of heart contraction', 'regulation of the force of heart contraction by cardiac conduction', 'relaxation of cardiac muscle']['adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'blood circulation', 'cardiac muscle tissue development', 'muscle cell cellular homeostasis', 'negative regulation of ATP-dependent activity', 'negative regulation of ATPase-coupled calcium transmembrane transporter activity', 'negative regulation of calcium ion binding', 'negative regulation of calcium ion import', 'negative regulation of calcium ion import into sarcoplasmic reticulum', 'negative regulation of calcium ion transmembrane transporter activity', 'negative regulation of calcium ion transport', 'negative regulation of catalytic activity', 'negative regulation of heart rate', 'Notch signaling pathway', 'regulation of ATPase-coupled calcium transmembrane transporter activity', 'regulation of calcium ion transport', 'regulation of cardiac muscle cell contraction', 'regulation of cardiac muscle cell membrane potential', 'regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion', 'regulation of cytosolic calcium ion concentration', 'regulation of heart contraction', 'regulation of relaxation of cardiac muscle', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of the force of heart contraction', 'regulation of the force of heart contraction by cardiac conduction', 'relaxation of cardiac muscle']
Thioredoxin
32
Nuclear factor NF-kappa-B p105 subunit
61
2.0
60
0.82
P10599P19838['activation of protein kinase B activity', 'cell redox homeostasis', 'negative regulation of hydrogen peroxide-induced cell death', 'negative regulation of protein export from nucleus', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of DNA binding', 'positive regulation of peptidyl-cysteine S-nitrosylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase B signaling', 'response to nitric oxide', 'response to radiation']['apoptotic process', 'cellular response to angiotensin', 'cellular response to dsRNA', 'cellular response to interleukin-1', 'cellular response to interleukin-6', 'cellular response to lipopolysaccharide', 'cellular response to mechanical stimulus', 'cellular response to nicotine', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'inflammatory response', 'JNK cascade', 'mammary gland involution', 'negative regulation of apoptotic process', 'negative regulation of calcidiol 1-monooxygenase activity', 'negative regulation of cholesterol transport', 'negative regulation of gene expression', 'negative regulation of inflammatory response', 'negative regulation of interleukin-12 production', 'negative regulation of protein metabolic process', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of vitamin D biosynthetic process', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of hyaluronan biosynthetic process', 'positive regulation of lipid storage', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of miRNA metabolic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'regulation of transcription by RNA polymerase II', 'response to muscle stretch', 'transcription by RNA polymerase II']
Trefoil factor 3
57
Trefoil factor 3
78
7.7
84
0.15
Q07654Q07654['maintenance of gastrointestinal epithelium', 'regulation of glucose metabolic process']['maintenance of gastrointestinal epithelium', 'regulation of glucose metabolic process']
C-C motif chemokine 4
74
C-C motif chemokine 4
34
9.8
77
0.13
P13236P13236['cell adhesion', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'eosinophil chemotaxis', 'establishment or maintenance of cell polarity', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'neutrophil chemotaxis', 'positive regulation of calcium ion transport', 'positive regulation of calcium-mediated signaling', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of natural killer cell chemotaxis', 'response to toxic substance', 'response to virus', 'signal transduction']['cell adhesion', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'eosinophil chemotaxis', 'establishment or maintenance of cell polarity', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'neutrophil chemotaxis', 'positive regulation of calcium ion transport', 'positive regulation of calcium-mediated signaling', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of natural killer cell chemotaxis', 'response to toxic substance', 'response to virus', 'signal transduction']
Trefoil factor 3
78
Trefoil factor 3
42
7.7
75
0.17
Q07654Q07654['maintenance of gastrointestinal epithelium', 'regulation of glucose metabolic process']['maintenance of gastrointestinal epithelium', 'regulation of glucose metabolic process']
Tumor necrosis factor receptor superfamily member 16
257
Tumor necrosis factor receptor superfamily member 16
257
2.1
48
1.01
P07174P07174['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'axon guidance', 'cellular glucose homeostasis', 'cellular response to amyloid-beta', 'cellular response to oxidative stress', 'central nervous system development', 'circadian regulation of gene expression', 'circadian rhythm', 'detection of temperature stimulus', 'dorsal aorta development', 'glucose homeostasis', 'hair follicle morphogenesis', 'intracellular protein transport', 'negative regulation of angiogenesis', 'negative regulation of apoptotic process', 'negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'negative regulation of cell migration', 'negative regulation of dendritic spine development', 'negative regulation of fibroblast growth factor receptor signaling pathway', 'negative regulation of hair follicle development', 'negative regulation of mitochondrial depolarization', 'negative regulation of neuron apoptotic process', 'negative regulation of neuron projection development', 'nerve development', 'neuron apoptotic process', 'positive regulation of apoptotic process', 'positive regulation of apoptotic signaling pathway', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of fibroblast proliferation', 'positive regulation of MAPK cascade', 'positive regulation of miRNA transcription', 'positive regulation of myelination', 'positive regulation of neural precursor cell proliferation', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of neuron projection development', 'positive regulation of odontogenesis of dentin-containing tooth', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of Rho protein signal transduction', 'positive regulation of synaptic transmission, cholinergic', 'positive regulation of synaptic transmission, glutamatergic', 'regulation of cell death', 'regulation of gene expression', 'regulation of reactive oxygen species metabolic process', 'response to lipopolysaccharide', 'response to wounding', 'Rho protein signal transduction', 'sensory perception of pain', 'signal transduction', 'skeletal muscle cell differentiation', 'skin development']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'axon guidance', 'cellular glucose homeostasis', 'cellular response to amyloid-beta', 'cellular response to oxidative stress', 'central nervous system development', 'circadian regulation of gene expression', 'circadian rhythm', 'detection of temperature stimulus', 'dorsal aorta development', 'glucose homeostasis', 'hair follicle morphogenesis', 'intracellular protein transport', 'negative regulation of angiogenesis', 'negative regulation of apoptotic process', 'negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'negative regulation of cell migration', 'negative regulation of dendritic spine development', 'negative regulation of fibroblast growth factor receptor signaling pathway', 'negative regulation of hair follicle development', 'negative regulation of mitochondrial depolarization', 'negative regulation of neuron apoptotic process', 'negative regulation of neuron projection development', 'nerve development', 'neuron apoptotic process', 'positive regulation of apoptotic process', 'positive regulation of apoptotic signaling pathway', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of fibroblast proliferation', 'positive regulation of MAPK cascade', 'positive regulation of miRNA transcription', 'positive regulation of myelination', 'positive regulation of neural precursor cell proliferation', 'positive regulation of neuron death', 'positive regulation of neuron differentiation', 'positive regulation of neuron projection development', 'positive regulation of odontogenesis of dentin-containing tooth', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of Rho protein signal transduction', 'positive regulation of synaptic transmission, cholinergic', 'positive regulation of synaptic transmission, glutamatergic', 'regulation of cell death', 'regulation of gene expression', 'regulation of reactive oxygen species metabolic process', 'response to lipopolysaccharide', 'response to wounding', 'Rho protein signal transduction', 'sensory perception of pain', 'signal transduction', 'skeletal muscle cell differentiation', 'skin development']
C-C motif chemokine 5
57
C-C motif chemokine 5
34
10.0
60
0.17
P30882P30882['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'eosinophil chemotaxis', 'epithelial cell proliferation', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of cell death', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of macrophage apoptotic process', 'negative regulation of neuron death', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of chemokine (C-X-C motif) ligand 2 production', 'positive regulation of defense response to virus by host', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fever generation', 'positive regulation of gene expression', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of macrophage chemotaxis', 'positive regulation of mast cell chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of osteoclast differentiation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'protein kinase B signaling', 'pseudopodium assembly', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to cytokine', 'response to interferon-gamma', 'response to toxic substance', 'response to tumor necrosis factor', 'T-helper 1 cell diapedesis']['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'eosinophil chemotaxis', 'epithelial cell proliferation', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of cell death', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of macrophage apoptotic process', 'negative regulation of neuron death', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of chemokine (C-X-C motif) ligand 2 production', 'positive regulation of defense response to virus by host', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fever generation', 'positive regulation of gene expression', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of macrophage chemotaxis', 'positive regulation of mast cell chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of osteoclast differentiation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'protein kinase B signaling', 'pseudopodium assembly', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to cytokine', 'response to interferon-gamma', 'response to toxic substance', 'response to tumor necrosis factor', 'T-helper 1 cell diapedesis']
Cardiac phospholamban
41
Cardiac phospholamban
41
9.8
64
0.16
P26678P26678['adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'blood circulation', 'cardiac muscle tissue development', 'muscle cell cellular homeostasis', 'negative regulation of ATP-dependent activity', 'negative regulation of ATPase-coupled calcium transmembrane transporter activity', 'negative regulation of calcium ion binding', 'negative regulation of calcium ion import', 'negative regulation of calcium ion import into sarcoplasmic reticulum', 'negative regulation of calcium ion transmembrane transporter activity', 'negative regulation of calcium ion transport', 'negative regulation of catalytic activity', 'negative regulation of heart rate', 'Notch signaling pathway', 'regulation of ATPase-coupled calcium transmembrane transporter activity', 'regulation of calcium ion transport', 'regulation of cardiac muscle cell contraction', 'regulation of cardiac muscle cell membrane potential', 'regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion', 'regulation of cytosolic calcium ion concentration', 'regulation of heart contraction', 'regulation of relaxation of cardiac muscle', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of the force of heart contraction', 'regulation of the force of heart contraction by cardiac conduction', 'relaxation of cardiac muscle']['adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'blood circulation', 'cardiac muscle tissue development', 'muscle cell cellular homeostasis', 'negative regulation of ATP-dependent activity', 'negative regulation of ATPase-coupled calcium transmembrane transporter activity', 'negative regulation of calcium ion binding', 'negative regulation of calcium ion import', 'negative regulation of calcium ion import into sarcoplasmic reticulum', 'negative regulation of calcium ion transmembrane transporter activity', 'negative regulation of calcium ion transport', 'negative regulation of catalytic activity', 'negative regulation of heart rate', 'Notch signaling pathway', 'regulation of ATPase-coupled calcium transmembrane transporter activity', 'regulation of calcium ion transport', 'regulation of cardiac muscle cell contraction', 'regulation of cardiac muscle cell membrane potential', 'regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion', 'regulation of cytosolic calcium ion concentration', 'regulation of heart contraction', 'regulation of relaxation of cardiac muscle', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of the force of heart contraction', 'regulation of the force of heart contraction by cardiac conduction', 'relaxation of cardiac muscle']
Insulin-like 3
34
Insulin-like 3
115
7.7
55
0.24
P51460P51460['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'cell-cell signaling', 'male gonad development', 'negative regulation of apoptotic process', 'negative regulation of cell population proliferation', 'oocyte maturation', 'positive regulation of cAMP-mediated signaling', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of wound healing', 'spermatogenesis']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'cell-cell signaling', 'male gonad development', 'negative regulation of apoptotic process', 'negative regulation of cell population proliferation', 'oocyte maturation', 'positive regulation of cAMP-mediated signaling', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of wound healing', 'spermatogenesis']
Defensin alpha-like protein 1
67
Defensin alpha-like protein 1
67
7.3
64
0.21
Q4JEI2Q4JEI2['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']
Cardiac phospholamban
36
Cardiac phospholamban
41
10.0
64
0.16
P26678P26678['adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'blood circulation', 'cardiac muscle tissue development', 'muscle cell cellular homeostasis', 'negative regulation of ATP-dependent activity', 'negative regulation of ATPase-coupled calcium transmembrane transporter activity', 'negative regulation of calcium ion binding', 'negative regulation of calcium ion import', 'negative regulation of calcium ion import into sarcoplasmic reticulum', 'negative regulation of calcium ion transmembrane transporter activity', 'negative regulation of calcium ion transport', 'negative regulation of catalytic activity', 'negative regulation of heart rate', 'Notch signaling pathway', 'regulation of ATPase-coupled calcium transmembrane transporter activity', 'regulation of calcium ion transport', 'regulation of cardiac muscle cell contraction', 'regulation of cardiac muscle cell membrane potential', 'regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion', 'regulation of cytosolic calcium ion concentration', 'regulation of heart contraction', 'regulation of relaxation of cardiac muscle', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of the force of heart contraction', 'regulation of the force of heart contraction by cardiac conduction', 'relaxation of cardiac muscle']['adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'blood circulation', 'cardiac muscle tissue development', 'muscle cell cellular homeostasis', 'negative regulation of ATP-dependent activity', 'negative regulation of ATPase-coupled calcium transmembrane transporter activity', 'negative regulation of calcium ion binding', 'negative regulation of calcium ion import', 'negative regulation of calcium ion import into sarcoplasmic reticulum', 'negative regulation of calcium ion transmembrane transporter activity', 'negative regulation of calcium ion transport', 'negative regulation of catalytic activity', 'negative regulation of heart rate', 'Notch signaling pathway', 'regulation of ATPase-coupled calcium transmembrane transporter activity', 'regulation of calcium ion transport', 'regulation of cardiac muscle cell contraction', 'regulation of cardiac muscle cell membrane potential', 'regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion', 'regulation of cytosolic calcium ion concentration', 'regulation of heart contraction', 'regulation of relaxation of cardiac muscle', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of the force of heart contraction', 'regulation of the force of heart contraction by cardiac conduction', 'relaxation of cardiac muscle']
Insulin
90
Insulin
43
10.0
52
0.19
P01317P01317['estradiol secretion', 'feeding behavior', 'glucose import in response to insulin stimulus', 'glucose metabolic process', 'negative regulation of apoptotic process', 'negative regulation of appetite', 'negative regulation of lactation', 'negative regulation of lipid catabolic process', 'positive regulation of blood circulation', 'positive regulation of cell maturation', 'positive regulation of gene expression', 'positive regulation of insulin secretion', 'positive regulation of lactation', 'positive regulation of mammary gland epithelial cell proliferation', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Rho protein signal transduction', 'protein secretion', 'response to butyrate', 'response to food', 'response to glucose', 'response to growth hormone', 'response to heat', 'response to L-arginine', 'response to nutrient levels']['estradiol secretion', 'feeding behavior', 'glucose import in response to insulin stimulus', 'glucose metabolic process', 'negative regulation of apoptotic process', 'negative regulation of appetite', 'negative regulation of lactation', 'negative regulation of lipid catabolic process', 'positive regulation of blood circulation', 'positive regulation of cell maturation', 'positive regulation of gene expression', 'positive regulation of insulin secretion', 'positive regulation of lactation', 'positive regulation of mammary gland epithelial cell proliferation', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Rho protein signal transduction', 'protein secretion', 'response to butyrate', 'response to food', 'response to glucose', 'response to growth hormone', 'response to heat', 'response to L-arginine', 'response to nutrient levels']
Relaxin-3
47
Relaxin-3
142
2.0
nan
nan
Q8WXF3Q8WXF3[][]
Histone lysine acetyltransferase CREBBP
429
Hypoxia-inducible factor 1-alpha
780
9.7
61
0.17
P45481Q16665['behavioral response to cocaine', 'cell population proliferation', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to UV', 'cellular response to virus', 'face morphogenesis', 'germ-line stem cell population maintenance', 'histone acetylation', 'histone glutamine methylation', 'long-term memory', 'N-terminal peptidyl-lysine acetylation', 'negative regulation of interferon-beta production', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of viral process', 'positive regulation of cell adhesion molecule production', 'positive regulation of CREB transcription factor activity', 'positive regulation of dendritic spine development', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of G1/S transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta receptor signaling pathway', 'protein acetylation', 'protein destabilization', 'regulation of transcription, DNA-templated', 'rhythmic process']['angiogenesis', 'axonal transport of mitochondrion', 'B-1 B cell homeostasis', 'bone mineralization', 'cardiac ventricle morphogenesis', 'cellular glucose homeostasis', 'cellular iron ion homeostasis', 'cellular response to hypoxia', 'cellular response to interleukin-1', 'cellular response to virus', 'cerebral cortex development', 'chondrocyte differentiation', 'collagen metabolic process', 'connective tissue replacement involved in inflammatory response wound healing', 'digestive tract morphogenesis', 'dopaminergic neuron differentiation', 'elastin metabolic process', 'embryonic hemopoiesis', 'embryonic placenta development', 'epithelial cell differentiation involved in mammary gland alveolus development', 'epithelial to mesenchymal transition', 'glandular epithelial cell maturation', 'heart looping', 'hemoglobin biosynthetic process', 'hypoxia-inducible factor-1alpha signaling pathway', 'insulin secretion involved in cellular response to glucose stimulus', 'intestinal epithelial cell maturation', 'iris morphogenesis', 'lactate metabolic process', 'lactation', 'mesenchymal cell apoptotic process', 'muscle cell cellular homeostasis', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'negative regulation of growth', 'negative regulation of mesenchymal cell apoptotic process', 'negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of thymocyte apoptotic process', 'negative regulation of TOR signaling', 'neural crest cell migration', 'neural fold elevation formation', 'neuroblast proliferation', 'neuron apoptotic process', 'outflow tract morphogenesis', 'oxygen homeostasis', 'positive regulation of angiogenesis', 'positive regulation of autophagy of mitochondrion', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of chemokine production', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of erythrocyte differentiation', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of hormone biosynthetic process', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of macroautophagy', 'positive regulation of miRNA transcription', 'positive regulation of neuroblast proliferation', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of signaling receptor activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of aerobic respiration', 'regulation of gene expression', 'regulation of glycolytic process', 'regulation of protein neddylation', 'regulation of transcription by RNA polymerase II', 'regulation of transcription from RNA polymerase II promoter in response to oxidative stress', 'regulation of transcription, DNA-templated', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to iron ion', 'response to muscle activity', 'response to reactive oxygen species', 'retina vasculature development in camera-type eye', 'signal transduction', 'TOR signaling', 'vascular endothelial growth factor production', 'visual learning']
Defensin alpha-like protein 1
65
Defensin alpha-like protein 1
67
7.4
68
0.2
Q4JEI2Q4JEI2['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']
C-C motif chemokine 5
34
C-C motif chemokine 5
33
10.0
72
0.14
P30882P30882['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'eosinophil chemotaxis', 'epithelial cell proliferation', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of cell death', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of macrophage apoptotic process', 'negative regulation of neuron death', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of chemokine (C-X-C motif) ligand 2 production', 'positive regulation of defense response to virus by host', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fever generation', 'positive regulation of gene expression', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of macrophage chemotaxis', 'positive regulation of mast cell chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of osteoclast differentiation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'protein kinase B signaling', 'pseudopodium assembly', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to cytokine', 'response to interferon-gamma', 'response to toxic substance', 'response to tumor necrosis factor', 'T-helper 1 cell diapedesis']['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'eosinophil chemotaxis', 'epithelial cell proliferation', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of cell death', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of macrophage apoptotic process', 'negative regulation of neuron death', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of chemokine (C-X-C motif) ligand 2 production', 'positive regulation of defense response to virus by host', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fever generation', 'positive regulation of gene expression', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of macrophage chemotaxis', 'positive regulation of mast cell chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of osteoclast differentiation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'protein kinase B signaling', 'pseudopodium assembly', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to cytokine', 'response to interferon-gamma', 'response to toxic substance', 'response to tumor necrosis factor', 'T-helper 1 cell diapedesis']
Fibroblast growth factor receptor substrate 3
91
ALK tyrosine kinase receptor
1579
8.9
58
0.19
O43559Q9UM73['fibroblast growth factor receptor signaling pathway', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway']['adult behavior', 'energy homeostasis', 'hippocampus development', 'negative regulation of lipid catabolic process', 'neuron development', 'peptidyl-tyrosine autophosphorylation', 'phosphorylation', 'positive regulation of dendrite development', 'positive regulation of kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of NF-kappaB transcription factor activity', 'protein autophosphorylation', 'regulation of apoptotic process', 'regulation of cell population proliferation', 'regulation of dopamine receptor signaling pathway', 'regulation of neuron differentiation', 'response to environmental enrichment', 'signal transduction', 'swimming behavior', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Insulin-like 3
115
Insulin-like 3
46
9.7
59
0.17
P51460P51460['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'cell-cell signaling', 'male gonad development', 'negative regulation of apoptotic process', 'negative regulation of cell population proliferation', 'oocyte maturation', 'positive regulation of cAMP-mediated signaling', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of wound healing', 'spermatogenesis']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'cell-cell signaling', 'male gonad development', 'negative regulation of apoptotic process', 'negative regulation of cell population proliferation', 'oocyte maturation', 'positive regulation of cAMP-mediated signaling', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of wound healing', 'spermatogenesis']
Cyclin-dependent kinase 2-associated protein 2
116
Cyclin-dependent kinase 2-associated protein 2
116
7.3
75
0.18
O75956O75956['negative regulation of G1/S transition of mitotic cell cycle', 'regulation of microtubule cytoskeleton organization', 'regulation of stem cell division']['negative regulation of G1/S transition of mitotic cell cycle', 'regulation of microtubule cytoskeleton organization', 'regulation of stem cell division']
Transcription factor HES-1
146
Transcription factor HES-1
117
6.0
69
0.24
Q14469Q14469['adenohypophysis development', 'amacrine cell differentiation', 'anterior/posterior pattern specification', 'artery morphogenesis', 'ascending aorta morphogenesis', 'BMP signaling pathway', 'Cajal-Retzius cell differentiation', 'cardiac neural crest cell development involved in outflow tract morphogenesis', 'cell adhesion', 'cell fate determination', 'cell maturation', 'cell migration', 'cell morphogenesis involved in neuron differentiation', 'cellular response to fatty acid', 'cellular response to interleukin-1', 'cellular response to nerve growth factor stimulus', 'cellular response to tumor necrosis factor', 'cochlea development', 'comma-shaped body morphogenesis', 'common bile duct development', 'embryonic heart tube morphogenesis', 'establishment of epithelial cell polarity', 'forebrain radial glial cell differentiation', 'glomerulus vasculature development', 'hindbrain morphogenesis', 'inner ear auditory receptor cell differentiation', 'inner ear receptor cell stereocilium organization', 'labyrinthine layer blood vessel development', 'lateral inhibition', 'liver development', 'lung development', 'metanephric nephron tubule morphogenesis', 'midbrain development', 'midbrain-hindbrain boundary morphogenesis', 'negative regulation of amacrine cell differentiation', 'negative regulation of calcium ion import', 'negative regulation of cell fate determination', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of forebrain neuron differentiation', 'negative regulation of gene expression', 'negative regulation of glial cell proliferation', 'negative regulation of inner ear auditory receptor cell differentiation', 'negative regulation of neuron differentiation', 'negative regulation of neuron projection development', 'negative regulation of oligodendrocyte differentiation', 'negative regulation of pancreatic A cell differentiation', 'negative regulation of pro-B cell differentiation', 'negative regulation of stem cell differentiation', 'negative regulation of stomach neuroendocrine cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'nervous system development', 'neuronal stem cell population maintenance', 'Notch signaling pathway', 'oculomotor nerve development', 'outflow tract morphogenesis', 'pancreatic A cell differentiation', 'pharyngeal arch artery morphogenesis', 'positive regulation of astrocyte differentiation', 'positive regulation of BMP signaling pathway', 'positive regulation of cell population proliferation', 'positive regulation of DNA binding', 'positive regulation of gene expression', 'positive regulation of mitotic cell cycle, embryonic', 'positive regulation of Notch signaling pathway', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of T cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tyrosine phosphorylation of STAT protein', 'protein-containing complex assembly', 'regulation of epithelial cell proliferation', 'regulation of fat cell differentiation', 'regulation of neurogenesis', 'regulation of protein-containing complex assembly', 'regulation of receptor signaling pathway via JAK-STAT', 'regulation of secondary heart field cardioblast proliferation', 'regulation of timing of neuron differentiation', 'regulation of transcription by RNA polymerase II', 'renal interstitial fibroblast development', 'response to alkaloid', 'response to organic cyclic compound', 'response to thyroid hormone', 'S-shaped body morphogenesis', 'smoothened signaling pathway', 'somatic stem cell population maintenance', 'stomach neuroendocrine cell differentiation', 'T cell proliferation', 'telencephalon development', 'thymus development', 'trochlear nerve development', 'ureteric bud morphogenesis', 'vascular associated smooth muscle cell development', 'ventricular septum development', 'ventricular septum morphogenesis']['adenohypophysis development', 'amacrine cell differentiation', 'anterior/posterior pattern specification', 'artery morphogenesis', 'ascending aorta morphogenesis', 'BMP signaling pathway', 'Cajal-Retzius cell differentiation', 'cardiac neural crest cell development involved in outflow tract morphogenesis', 'cell adhesion', 'cell fate determination', 'cell maturation', 'cell migration', 'cell morphogenesis involved in neuron differentiation', 'cellular response to fatty acid', 'cellular response to interleukin-1', 'cellular response to nerve growth factor stimulus', 'cellular response to tumor necrosis factor', 'cochlea development', 'comma-shaped body morphogenesis', 'common bile duct development', 'embryonic heart tube morphogenesis', 'establishment of epithelial cell polarity', 'forebrain radial glial cell differentiation', 'glomerulus vasculature development', 'hindbrain morphogenesis', 'inner ear auditory receptor cell differentiation', 'inner ear receptor cell stereocilium organization', 'labyrinthine layer blood vessel development', 'lateral inhibition', 'liver development', 'lung development', 'metanephric nephron tubule morphogenesis', 'midbrain development', 'midbrain-hindbrain boundary morphogenesis', 'negative regulation of amacrine cell differentiation', 'negative regulation of calcium ion import', 'negative regulation of cell fate determination', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of forebrain neuron differentiation', 'negative regulation of gene expression', 'negative regulation of glial cell proliferation', 'negative regulation of inner ear auditory receptor cell differentiation', 'negative regulation of neuron differentiation', 'negative regulation of neuron projection development', 'negative regulation of oligodendrocyte differentiation', 'negative regulation of pancreatic A cell differentiation', 'negative regulation of pro-B cell differentiation', 'negative regulation of stem cell differentiation', 'negative regulation of stomach neuroendocrine cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'nervous system development', 'neuronal stem cell population maintenance', 'Notch signaling pathway', 'oculomotor nerve development', 'outflow tract morphogenesis', 'pancreatic A cell differentiation', 'pharyngeal arch artery morphogenesis', 'positive regulation of astrocyte differentiation', 'positive regulation of BMP signaling pathway', 'positive regulation of cell population proliferation', 'positive regulation of DNA binding', 'positive regulation of gene expression', 'positive regulation of mitotic cell cycle, embryonic', 'positive regulation of Notch signaling pathway', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of T cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tyrosine phosphorylation of STAT protein', 'protein-containing complex assembly', 'regulation of epithelial cell proliferation', 'regulation of fat cell differentiation', 'regulation of neurogenesis', 'regulation of protein-containing complex assembly', 'regulation of receptor signaling pathway via JAK-STAT', 'regulation of secondary heart field cardioblast proliferation', 'regulation of timing of neuron differentiation', 'regulation of transcription by RNA polymerase II', 'renal interstitial fibroblast development', 'response to alkaloid', 'response to organic cyclic compound', 'response to thyroid hormone', 'S-shaped body morphogenesis', 'smoothened signaling pathway', 'somatic stem cell population maintenance', 'stomach neuroendocrine cell differentiation', 'T cell proliferation', 'telencephalon development', 'thymus development', 'trochlear nerve development', 'ureteric bud morphogenesis', 'vascular associated smooth muscle cell development', 'ventricular septum development', 'ventricular septum morphogenesis']
Tumor necrosis factor receptor superfamily member 16
381
Tumor necrosis factor receptor type 1-associated DEATH domain protein
241
7.8
71
0.18
P08138Q15628['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'axon guidance', 'cellular glucose homeostasis', 'cellular response to amyloid-beta', 'central nervous system development', 'circadian regulation of gene expression', 'detection of temperature stimulus', 'dorsal aorta development', 'fibroblast growth factor receptor signaling pathway', 'fibroblast proliferation', 'glucose homeostasis', 'hair follicle morphogenesis', 'intracellular protein transport', 'negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'negative regulation of cell migration', 'negative regulation of fibroblast growth factor receptor signaling pathway', 'negative regulation of hair follicle development', 'nerve development', 'neuron apoptotic process', 'odontogenesis of dentin-containing tooth', 'positive regulation of apoptotic signaling pathway', 'positive regulation of fibroblast proliferation', 'positive regulation of miRNA transcription', 'positive regulation of odontogenesis of dentin-containing tooth', 'positive regulation of protein localization to nucleus', 'Rho protein signal transduction']['apoptotic process', 'cellular response to tumor necrosis factor', 'extrinsic apoptotic signaling pathway', 'extrinsic apoptotic signaling pathway via death domain receptors', 'positive regulation of apoptotic process', 'positive regulation of cell migration', 'positive regulation of hair follicle development', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of inflammatory response', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'signal transduction', 'tumor necrosis factor-mediated signaling pathway']
Relaxin-3
35
Insulin-like peptide INSL5
126
8.9
54
0.21
Q8WXF3Q9Y5Q6[]['positive regulation of feeding behavior']
C-C motif chemokine 5
33
C-C motif chemokine 5
57
7.8
60
0.21
P30882P30882['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'eosinophil chemotaxis', 'epithelial cell proliferation', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of cell death', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of macrophage apoptotic process', 'negative regulation of neuron death', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of chemokine (C-X-C motif) ligand 2 production', 'positive regulation of defense response to virus by host', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fever generation', 'positive regulation of gene expression', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of macrophage chemotaxis', 'positive regulation of mast cell chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of osteoclast differentiation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'protein kinase B signaling', 'pseudopodium assembly', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to cytokine', 'response to interferon-gamma', 'response to toxic substance', 'response to tumor necrosis factor', 'T-helper 1 cell diapedesis']['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'eosinophil chemotaxis', 'epithelial cell proliferation', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of cell death', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of macrophage apoptotic process', 'negative regulation of neuron death', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of chemokine (C-X-C motif) ligand 2 production', 'positive regulation of defense response to virus by host', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fever generation', 'positive regulation of gene expression', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of macrophage chemotaxis', 'positive regulation of mast cell chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of osteoclast differentiation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'protein kinase B signaling', 'pseudopodium assembly', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to cytokine', 'response to interferon-gamma', 'response to toxic substance', 'response to tumor necrosis factor', 'T-helper 1 cell diapedesis']
C-C motif chemokine 5
57
C-C motif chemokine 5
57
10.0
47
0.21
P30882P30882['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'eosinophil chemotaxis', 'epithelial cell proliferation', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of cell death', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of macrophage apoptotic process', 'negative regulation of neuron death', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of chemokine (C-X-C motif) ligand 2 production', 'positive regulation of defense response to virus by host', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fever generation', 'positive regulation of gene expression', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of macrophage chemotaxis', 'positive regulation of mast cell chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of osteoclast differentiation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'protein kinase B signaling', 'pseudopodium assembly', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to cytokine', 'response to interferon-gamma', 'response to toxic substance', 'response to tumor necrosis factor', 'T-helper 1 cell diapedesis']['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'eosinophil chemotaxis', 'epithelial cell proliferation', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of cell death', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of macrophage apoptotic process', 'negative regulation of neuron death', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of chemokine (C-X-C motif) ligand 2 production', 'positive regulation of defense response to virus by host', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fever generation', 'positive regulation of gene expression', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of macrophage chemotaxis', 'positive regulation of mast cell chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of osteoclast differentiation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'protein kinase B signaling', 'pseudopodium assembly', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to cytokine', 'response to interferon-gamma', 'response to toxic substance', 'response to tumor necrosis factor', 'T-helper 1 cell diapedesis']
Cyclin-dependent kinase 2-associated protein 1
105
Cyclin-dependent kinase 2-associated protein 1
105
7.4
57
0.24
O14519O14519['cell cycle', 'DNA-templated DNA replication', 'positive regulation of protein phosphorylation']['cell cycle', 'DNA-templated DNA replication', 'positive regulation of protein phosphorylation']
Histone lysine acetyltransferase CREBBP
379
Hypoxia-inducible factor 1-alpha
780
9.2
57
0.19
P45481Q16665['behavioral response to cocaine', 'cell population proliferation', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to UV', 'cellular response to virus', 'face morphogenesis', 'germ-line stem cell population maintenance', 'histone acetylation', 'histone glutamine methylation', 'long-term memory', 'N-terminal peptidyl-lysine acetylation', 'negative regulation of interferon-beta production', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of viral process', 'positive regulation of cell adhesion molecule production', 'positive regulation of CREB transcription factor activity', 'positive regulation of dendritic spine development', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of G1/S transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta receptor signaling pathway', 'protein acetylation', 'protein destabilization', 'regulation of transcription, DNA-templated', 'rhythmic process']['angiogenesis', 'axonal transport of mitochondrion', 'B-1 B cell homeostasis', 'bone mineralization', 'cardiac ventricle morphogenesis', 'cellular glucose homeostasis', 'cellular iron ion homeostasis', 'cellular response to hypoxia', 'cellular response to interleukin-1', 'cellular response to virus', 'cerebral cortex development', 'chondrocyte differentiation', 'collagen metabolic process', 'connective tissue replacement involved in inflammatory response wound healing', 'digestive tract morphogenesis', 'dopaminergic neuron differentiation', 'elastin metabolic process', 'embryonic hemopoiesis', 'embryonic placenta development', 'epithelial cell differentiation involved in mammary gland alveolus development', 'epithelial to mesenchymal transition', 'glandular epithelial cell maturation', 'heart looping', 'hemoglobin biosynthetic process', 'hypoxia-inducible factor-1alpha signaling pathway', 'insulin secretion involved in cellular response to glucose stimulus', 'intestinal epithelial cell maturation', 'iris morphogenesis', 'lactate metabolic process', 'lactation', 'mesenchymal cell apoptotic process', 'muscle cell cellular homeostasis', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'negative regulation of growth', 'negative regulation of mesenchymal cell apoptotic process', 'negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of thymocyte apoptotic process', 'negative regulation of TOR signaling', 'neural crest cell migration', 'neural fold elevation formation', 'neuroblast proliferation', 'neuron apoptotic process', 'outflow tract morphogenesis', 'oxygen homeostasis', 'positive regulation of angiogenesis', 'positive regulation of autophagy of mitochondrion', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of chemokine production', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of erythrocyte differentiation', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of hormone biosynthetic process', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of macroautophagy', 'positive regulation of miRNA transcription', 'positive regulation of neuroblast proliferation', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of signaling receptor activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of aerobic respiration', 'regulation of gene expression', 'regulation of glycolytic process', 'regulation of protein neddylation', 'regulation of transcription by RNA polymerase II', 'regulation of transcription from RNA polymerase II promoter in response to oxidative stress', 'regulation of transcription, DNA-templated', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to iron ion', 'response to muscle activity', 'response to reactive oxygen species', 'retina vasculature development in camera-type eye', 'signal transduction', 'TOR signaling', 'vascular endothelial growth factor production', 'visual learning']
Defensin alpha-like protein 1
65
Defensin alpha-like protein 1
77
2.0
72
0.69
Q4JEI2Q4JEI2['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']
Protein S100-A11
13
Protein S100-A11
13
3.6
78
0.36
P31949P31949['negative regulation of cell population proliferation', 'negative regulation of DNA replication', 'positive regulation of smooth muscle cell migration', 'signal transduction']['negative regulation of cell population proliferation', 'negative regulation of DNA replication', 'positive regulation of smooth muscle cell migration', 'signal transduction']
Relaxin-3
35
Insulin-like peptide INSL5
121
7.6
49
0.27
Q8WXF3Q9Y5Q6[]['positive regulation of feeding behavior']
Defensin alpha-like protein 1
77
Defensin alpha-like protein 1
67
7.9
68
0.19
Q4JEI2Q4JEI2['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']
Histone lysine acetyltransferase CREBBP
384
Hypoxia-inducible factor 1-alpha
780
9.8
59
0.17
P45481Q16665['behavioral response to cocaine', 'cell population proliferation', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to UV', 'cellular response to virus', 'face morphogenesis', 'germ-line stem cell population maintenance', 'histone acetylation', 'histone glutamine methylation', 'long-term memory', 'N-terminal peptidyl-lysine acetylation', 'negative regulation of interferon-beta production', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of viral process', 'positive regulation of cell adhesion molecule production', 'positive regulation of CREB transcription factor activity', 'positive regulation of dendritic spine development', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of G1/S transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta receptor signaling pathway', 'protein acetylation', 'protein destabilization', 'regulation of transcription, DNA-templated', 'rhythmic process']['angiogenesis', 'axonal transport of mitochondrion', 'B-1 B cell homeostasis', 'bone mineralization', 'cardiac ventricle morphogenesis', 'cellular glucose homeostasis', 'cellular iron ion homeostasis', 'cellular response to hypoxia', 'cellular response to interleukin-1', 'cellular response to virus', 'cerebral cortex development', 'chondrocyte differentiation', 'collagen metabolic process', 'connective tissue replacement involved in inflammatory response wound healing', 'digestive tract morphogenesis', 'dopaminergic neuron differentiation', 'elastin metabolic process', 'embryonic hemopoiesis', 'embryonic placenta development', 'epithelial cell differentiation involved in mammary gland alveolus development', 'epithelial to mesenchymal transition', 'glandular epithelial cell maturation', 'heart looping', 'hemoglobin biosynthetic process', 'hypoxia-inducible factor-1alpha signaling pathway', 'insulin secretion involved in cellular response to glucose stimulus', 'intestinal epithelial cell maturation', 'iris morphogenesis', 'lactate metabolic process', 'lactation', 'mesenchymal cell apoptotic process', 'muscle cell cellular homeostasis', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'negative regulation of growth', 'negative regulation of mesenchymal cell apoptotic process', 'negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of thymocyte apoptotic process', 'negative regulation of TOR signaling', 'neural crest cell migration', 'neural fold elevation formation', 'neuroblast proliferation', 'neuron apoptotic process', 'outflow tract morphogenesis', 'oxygen homeostasis', 'positive regulation of angiogenesis', 'positive regulation of autophagy of mitochondrion', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of chemokine production', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of erythrocyte differentiation', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of hormone biosynthetic process', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of macroautophagy', 'positive regulation of miRNA transcription', 'positive regulation of neuroblast proliferation', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of signaling receptor activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of aerobic respiration', 'regulation of gene expression', 'regulation of glycolytic process', 'regulation of protein neddylation', 'regulation of transcription by RNA polymerase II', 'regulation of transcription from RNA polymerase II promoter in response to oxidative stress', 'regulation of transcription, DNA-templated', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to iron ion', 'response to muscle activity', 'response to reactive oxygen species', 'retina vasculature development in camera-type eye', 'signal transduction', 'TOR signaling', 'vascular endothelial growth factor production', 'visual learning']
Trefoil factor 3
57
Trefoil factor 3
57
10.0
87
0.12
Q07654Q07654['maintenance of gastrointestinal epithelium', 'regulation of glucose metabolic process']['maintenance of gastrointestinal epithelium', 'regulation of glucose metabolic process']
Relaxin-3
35
Relaxin-3
128
8.9
55
0.2
Q8WXF3Q8WXF3[][]
Zinc finger HIT domain-containing protein 3
143
FMR1-interacting protein NUFIP1
473
3.6
84
0.33
Q15649Q9UHK0['box C/D snoRNP assembly', 'maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)', 'regulation of transcription, DNA-templated', 'snoRNA localization']['box C/D snoRNP assembly', 'positive regulation of transcription by RNA polymerase II', 'RNA processing']
Protegrin-3
145
Protegrin-3
136
7.1
46
0.31
P32196P32196['antimicrobial humoral immune response mediated by antimicrobial peptide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response']
Protegrin-3
136
Protegrin-3
143
9.8
38
0.27
P32196P32196['antimicrobial humoral immune response mediated by antimicrobial peptide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response']
Relaxin-3
35
Relaxin-3
133
9.1
58
0.19
Q8WXF3Q8WXF3[][]
Defensin alpha-like protein 1
65
Defensin alpha-like protein 1
65
3.6
70
0.4
Q4JEI2Q4JEI2['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']
Defensin alpha-like protein 1
67
Defensin alpha-like protein 1
75
2.0
68
0.73
Q4JEI2Q4JEI2['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']
Insulin-like 3
120
Insulin-like 3
34
10.0
56
0.18
P51460P51460['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'cell-cell signaling', 'male gonad development', 'negative regulation of apoptotic process', 'negative regulation of cell population proliferation', 'oocyte maturation', 'positive regulation of cAMP-mediated signaling', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of wound healing', 'spermatogenesis']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'cell-cell signaling', 'male gonad development', 'negative regulation of apoptotic process', 'negative regulation of cell population proliferation', 'oocyte maturation', 'positive regulation of cAMP-mediated signaling', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of wound healing', 'spermatogenesis']
Insulin-like 3
120
Insulin-like 3
46
8.9
56
0.2
P51460P51460['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'cell-cell signaling', 'male gonad development', 'negative regulation of apoptotic process', 'negative regulation of cell population proliferation', 'oocyte maturation', 'positive regulation of cAMP-mediated signaling', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of wound healing', 'spermatogenesis']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'cell-cell signaling', 'male gonad development', 'negative regulation of apoptotic process', 'negative regulation of cell population proliferation', 'oocyte maturation', 'positive regulation of cAMP-mediated signaling', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of wound healing', 'spermatogenesis']
Beta-nerve growth factor
189
Beta-nerve growth factor
189
8.9
64
0.18
P01138P01138['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'extrinsic apoptotic signaling pathway via death domain receptors', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of cell population proliferation', 'negative regulation of neuron apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of collateral sprouting', 'positive regulation of DNA binding', 'positive regulation of gene expression', 'positive regulation of neuron differentiation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of Ras protein signal transduction', 'regulation of neuron differentiation', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'extrinsic apoptotic signaling pathway via death domain receptors', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of cell population proliferation', 'negative regulation of neuron apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of collateral sprouting', 'positive regulation of DNA binding', 'positive regulation of gene expression', 'positive regulation of neuron differentiation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of Ras protein signal transduction', 'regulation of neuron differentiation', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Tumor necrosis factor receptor superfamily member 16
256
Tumor necrosis factor receptor superfamily member 16
256
2.0
49
1.01
P08138P08138['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'axon guidance', 'cellular glucose homeostasis', 'cellular response to amyloid-beta', 'central nervous system development', 'circadian regulation of gene expression', 'detection of temperature stimulus', 'dorsal aorta development', 'fibroblast growth factor receptor signaling pathway', 'fibroblast proliferation', 'glucose homeostasis', 'hair follicle morphogenesis', 'intracellular protein transport', 'negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'negative regulation of cell migration', 'negative regulation of fibroblast growth factor receptor signaling pathway', 'negative regulation of hair follicle development', 'nerve development', 'neuron apoptotic process', 'odontogenesis of dentin-containing tooth', 'positive regulation of apoptotic signaling pathway', 'positive regulation of fibroblast proliferation', 'positive regulation of miRNA transcription', 'positive regulation of odontogenesis of dentin-containing tooth', 'positive regulation of protein localization to nucleus', 'Rho protein signal transduction']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'axon guidance', 'cellular glucose homeostasis', 'cellular response to amyloid-beta', 'central nervous system development', 'circadian regulation of gene expression', 'detection of temperature stimulus', 'dorsal aorta development', 'fibroblast growth factor receptor signaling pathway', 'fibroblast proliferation', 'glucose homeostasis', 'hair follicle morphogenesis', 'intracellular protein transport', 'negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'negative regulation of cell migration', 'negative regulation of fibroblast growth factor receptor signaling pathway', 'negative regulation of hair follicle development', 'nerve development', 'neuron apoptotic process', 'odontogenesis of dentin-containing tooth', 'positive regulation of apoptotic signaling pathway', 'positive regulation of fibroblast proliferation', 'positive regulation of miRNA transcription', 'positive regulation of odontogenesis of dentin-containing tooth', 'positive regulation of protein localization to nucleus', 'Rho protein signal transduction']
C-C motif chemokine 5
34
C-C motif chemokine 5
57
8.1
70
0.18
P13501P13501['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'chemokine-mediated signaling pathway', 'chemotaxis', 'dendritic cell chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of innate immune response', 'positive regulation of macrophage chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of translational initiation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of viral genome replication', 'protein kinase B signaling', 'regulation of chronic inflammatory response', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to toxic substance', 'response to virus']['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'cellular response to virus', 'chemokine-mediated signaling pathway', 'chemotaxis', 'dendritic cell chemotaxis', 'eosinophil chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of activation of Janus kinase activity', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of innate immune response', 'positive regulation of macrophage chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of translational initiation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of viral genome replication', 'protein kinase B signaling', 'regulation of chronic inflammatory response', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to toxic substance', 'response to virus']
C-C motif chemokine 2
34
C-C motif chemokine 2
75
10.0
80
0.13
P13500P13500['angiogenesis', 'animal organ morphogenesis', 'astrocyte cell migration', 'cell adhesion', 'cell surface receptor signaling pathway', 'cellular homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to lipopolysaccharide', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'cytoskeleton organization', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'helper T cell extravasation', 'humoral immune response', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of glial cell apoptotic process', 'negative regulation of natural killer cell chemotaxis', 'negative regulation of neuron apoptotic process', 'negative regulation of vascular endothelial cell proliferation', 'neutrophil chemotaxis', 'positive regulation of apoptotic cell clearance', 'positive regulation of calcium ion import', 'positive regulation of endothelial cell apoptotic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of nitric-oxide synthase biosynthetic process', 'positive regulation of NMDA glutamate receptor activity', 'positive regulation of synaptic transmission, glutamatergic', 'positive regulation of T cell activation', 'protein kinase B signaling', 'protein phosphorylation', 'receptor signaling pathway via JAK-STAT', 'regulation of cell shape', 'response to bacterium', 'sensory perception of pain', 'signal transduction', 'viral genome replication']['angiogenesis', 'animal organ morphogenesis', 'astrocyte cell migration', 'cell adhesion', 'cell surface receptor signaling pathway', 'cellular homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to lipopolysaccharide', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'cytoskeleton organization', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'helper T cell extravasation', 'humoral immune response', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of glial cell apoptotic process', 'negative regulation of natural killer cell chemotaxis', 'negative regulation of neuron apoptotic process', 'negative regulation of vascular endothelial cell proliferation', 'neutrophil chemotaxis', 'positive regulation of apoptotic cell clearance', 'positive regulation of calcium ion import', 'positive regulation of endothelial cell apoptotic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of nitric-oxide synthase biosynthetic process', 'positive regulation of NMDA glutamate receptor activity', 'positive regulation of synaptic transmission, glutamatergic', 'positive regulation of T cell activation', 'protein kinase B signaling', 'protein phosphorylation', 'receptor signaling pathway via JAK-STAT', 'regulation of cell shape', 'response to bacterium', 'sensory perception of pain', 'signal transduction', 'viral genome replication']
Transforming growth factor beta-1 proprotein
387
Transforming growth factor beta-1 proprotein
355
8.7
91
0.13
P01137P01137['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']
Beta-nerve growth factor
189
Beta-nerve growth factor
189
9.8
80
0.13
P01139P01139['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'adult locomotory behavior', 'axon extension', 'circadian rhythm', 'extrinsic apoptotic signaling pathway in absence of ligand', 'extrinsic apoptotic signaling pathway via death domain receptors', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of type B pancreatic cell apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron projection development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of axon extension', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of collateral sprouting', 'positive regulation of DNA binding', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of neuron differentiation', 'positive regulation of neuron maturation', 'positive regulation of neuron projection development', 'positive regulation of neurotrophin TRK receptor signaling pathway', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein autophosphorylation', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of protein ubiquitination', 'positive regulation of Ras protein signal transduction', 'positive regulation of stem cell proliferation', 'protein phosphorylation', 'regulation of neuron differentiation', 'regulation of neurotransmitter secretion', 'regulation of release of sequestered calcium ion into cytosol', 'sensory perception of pain', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'adult locomotory behavior', 'axon extension', 'circadian rhythm', 'extrinsic apoptotic signaling pathway in absence of ligand', 'extrinsic apoptotic signaling pathway via death domain receptors', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of type B pancreatic cell apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron projection development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of axon extension', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of collateral sprouting', 'positive regulation of DNA binding', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of neuron differentiation', 'positive regulation of neuron maturation', 'positive regulation of neuron projection development', 'positive regulation of neurotrophin TRK receptor signaling pathway', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein autophosphorylation', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of protein ubiquitination', 'positive regulation of Ras protein signal transduction', 'positive regulation of stem cell proliferation', 'protein phosphorylation', 'regulation of neuron differentiation', 'regulation of neurotransmitter secretion', 'regulation of release of sequestered calcium ion into cytosol', 'sensory perception of pain', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Trefoil factor 3
42
Trefoil factor 3
57
8.8
79
0.14
Q07654Q07654['maintenance of gastrointestinal epithelium', 'regulation of glucose metabolic process']['maintenance of gastrointestinal epithelium', 'regulation of glucose metabolic process']
Defensin alpha-like protein 1
75
Defensin alpha-like protein 1
77
7.3
74
0.18
Q4JEI2Q4JEI2['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']
Histone lysine acetyltransferase CREBBP
366
Hypoxia-inducible factor 1-alpha
780
9.1
64
0.17
P45481Q16665['behavioral response to cocaine', 'cell population proliferation', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to UV', 'cellular response to virus', 'face morphogenesis', 'germ-line stem cell population maintenance', 'histone acetylation', 'histone glutamine methylation', 'long-term memory', 'N-terminal peptidyl-lysine acetylation', 'negative regulation of interferon-beta production', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of viral process', 'positive regulation of cell adhesion molecule production', 'positive regulation of CREB transcription factor activity', 'positive regulation of dendritic spine development', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of G1/S transition of mitotic cell cycle', 'positive regulation of gene expression', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta receptor signaling pathway', 'protein acetylation', 'protein destabilization', 'regulation of transcription, DNA-templated', 'rhythmic process']['angiogenesis', 'axonal transport of mitochondrion', 'B-1 B cell homeostasis', 'bone mineralization', 'cardiac ventricle morphogenesis', 'cellular glucose homeostasis', 'cellular iron ion homeostasis', 'cellular response to hypoxia', 'cellular response to interleukin-1', 'cellular response to virus', 'cerebral cortex development', 'chondrocyte differentiation', 'collagen metabolic process', 'connective tissue replacement involved in inflammatory response wound healing', 'digestive tract morphogenesis', 'dopaminergic neuron differentiation', 'elastin metabolic process', 'embryonic hemopoiesis', 'embryonic placenta development', 'epithelial cell differentiation involved in mammary gland alveolus development', 'epithelial to mesenchymal transition', 'glandular epithelial cell maturation', 'heart looping', 'hemoglobin biosynthetic process', 'hypoxia-inducible factor-1alpha signaling pathway', 'insulin secretion involved in cellular response to glucose stimulus', 'intestinal epithelial cell maturation', 'iris morphogenesis', 'lactate metabolic process', 'lactation', 'mesenchymal cell apoptotic process', 'muscle cell cellular homeostasis', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'negative regulation of growth', 'negative regulation of mesenchymal cell apoptotic process', 'negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of thymocyte apoptotic process', 'negative regulation of TOR signaling', 'neural crest cell migration', 'neural fold elevation formation', 'neuroblast proliferation', 'neuron apoptotic process', 'outflow tract morphogenesis', 'oxygen homeostasis', 'positive regulation of angiogenesis', 'positive regulation of autophagy of mitochondrion', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of chemokine production', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of erythrocyte differentiation', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of hormone biosynthetic process', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of macroautophagy', 'positive regulation of miRNA transcription', 'positive regulation of neuroblast proliferation', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of signaling receptor activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of aerobic respiration', 'regulation of gene expression', 'regulation of glycolytic process', 'regulation of protein neddylation', 'regulation of transcription by RNA polymerase II', 'regulation of transcription from RNA polymerase II promoter in response to oxidative stress', 'regulation of transcription, DNA-templated', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to iron ion', 'response to muscle activity', 'response to reactive oxygen species', 'retina vasculature development in camera-type eye', 'signal transduction', 'TOR signaling', 'vascular endothelial growth factor production', 'visual learning']
Insulin
100
Insulin
43
9.8
47
0.22
P01308P01308['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']
Protein S100-A11
91
Protein S100-A11
13
9.0
71
0.16
P31949P31949['negative regulation of cell population proliferation', 'negative regulation of DNA replication', 'positive regulation of smooth muscle cell migration', 'signal transduction']['negative regulation of cell population proliferation', 'negative regulation of DNA replication', 'positive regulation of smooth muscle cell migration', 'signal transduction']
Protegrin-3
145
Protegrin-3
143
9.5
45
0.23
P32196P32196['antimicrobial humoral immune response mediated by antimicrobial peptide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response']
T-cell surface glycoprotein CD3 zeta chain
32
T-cell surface glycoprotein CD3 zeta chain
32
2.0
40
1.24
P20963P20963['adaptive immune response', 'alpha-beta T cell activation', 'cell surface receptor signaling pathway', 'Fc-gamma receptor signaling pathway', 'gamma-delta T cell activation', 'positive regulation of protein localization to cell surface', 'protein-containing complex assembly', 'T cell receptor signaling pathway']['adaptive immune response', 'alpha-beta T cell activation', 'cell surface receptor signaling pathway', 'Fc-gamma receptor signaling pathway', 'gamma-delta T cell activation', 'positive regulation of protein localization to cell surface', 'protein-containing complex assembly', 'T cell receptor signaling pathway']
Defensin alpha-like protein 1
75
Defensin alpha-like protein 1
75
3.8
74
0.36
Q4JEI2Q4JEI2['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']
T-cell surface glycoprotein CD8 alpha chain
217
Tyrosine-protein kinase Lck
20
3.9
38
0.67
P01732P06239['adaptive immune response', 'antigen processing and presentation', 'cell surface receptor signaling pathway', 'cytotoxic T cell differentiation', 'immune response', 'T cell activation', 'T cell mediated immunity', 'T cell receptor signaling pathway', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'B cell receptor signaling pathway', 'cell differentiation', 'cellular zinc ion homeostasis', 'Fc-gamma receptor signaling pathway', 'hemopoiesis', 'innate immune response', 'intracellular signal transduction', 'leukocyte migration', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'platelet activation', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of leukocyte cell-cell adhesion', 'positive regulation of T cell activation', 'positive regulation of T cell receptor signaling pathway', 'protein phosphorylation', 'regulation of lymphocyte activation', 'release of sequestered calcium ion into cytosol', 'response to xenobiotic stimulus', 'T cell costimulation', 'T cell differentiation', 'T cell receptor signaling pathway', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Defensin alpha-like protein 1
77
Defensin alpha-like protein 1
77
4.0
72
0.35
Q4JEI2Q4JEI2['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']
Transcription factor HES-1
117
Transcription factor HES-1
117
3.4
82
0.36
Q14469Q14469['adenohypophysis development', 'amacrine cell differentiation', 'anterior/posterior pattern specification', 'artery morphogenesis', 'ascending aorta morphogenesis', 'BMP signaling pathway', 'Cajal-Retzius cell differentiation', 'cardiac neural crest cell development involved in outflow tract morphogenesis', 'cell adhesion', 'cell fate determination', 'cell maturation', 'cell migration', 'cell morphogenesis involved in neuron differentiation', 'cellular response to fatty acid', 'cellular response to interleukin-1', 'cellular response to nerve growth factor stimulus', 'cellular response to tumor necrosis factor', 'cochlea development', 'comma-shaped body morphogenesis', 'common bile duct development', 'embryonic heart tube morphogenesis', 'establishment of epithelial cell polarity', 'forebrain radial glial cell differentiation', 'glomerulus vasculature development', 'hindbrain morphogenesis', 'inner ear auditory receptor cell differentiation', 'inner ear receptor cell stereocilium organization', 'labyrinthine layer blood vessel development', 'lateral inhibition', 'liver development', 'lung development', 'metanephric nephron tubule morphogenesis', 'midbrain development', 'midbrain-hindbrain boundary morphogenesis', 'negative regulation of amacrine cell differentiation', 'negative regulation of calcium ion import', 'negative regulation of cell fate determination', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of forebrain neuron differentiation', 'negative regulation of gene expression', 'negative regulation of glial cell proliferation', 'negative regulation of inner ear auditory receptor cell differentiation', 'negative regulation of neuron differentiation', 'negative regulation of neuron projection development', 'negative regulation of oligodendrocyte differentiation', 'negative regulation of pancreatic A cell differentiation', 'negative regulation of pro-B cell differentiation', 'negative regulation of stem cell differentiation', 'negative regulation of stomach neuroendocrine cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'nervous system development', 'neuronal stem cell population maintenance', 'Notch signaling pathway', 'oculomotor nerve development', 'outflow tract morphogenesis', 'pancreatic A cell differentiation', 'pharyngeal arch artery morphogenesis', 'positive regulation of astrocyte differentiation', 'positive regulation of BMP signaling pathway', 'positive regulation of cell population proliferation', 'positive regulation of DNA binding', 'positive regulation of gene expression', 'positive regulation of mitotic cell cycle, embryonic', 'positive regulation of Notch signaling pathway', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of T cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tyrosine phosphorylation of STAT protein', 'protein-containing complex assembly', 'regulation of epithelial cell proliferation', 'regulation of fat cell differentiation', 'regulation of neurogenesis', 'regulation of protein-containing complex assembly', 'regulation of receptor signaling pathway via JAK-STAT', 'regulation of secondary heart field cardioblast proliferation', 'regulation of timing of neuron differentiation', 'regulation of transcription by RNA polymerase II', 'renal interstitial fibroblast development', 'response to alkaloid', 'response to organic cyclic compound', 'response to thyroid hormone', 'S-shaped body morphogenesis', 'smoothened signaling pathway', 'somatic stem cell population maintenance', 'stomach neuroendocrine cell differentiation', 'T cell proliferation', 'telencephalon development', 'thymus development', 'trochlear nerve development', 'ureteric bud morphogenesis', 'vascular associated smooth muscle cell development', 'ventricular septum development', 'ventricular septum morphogenesis']['adenohypophysis development', 'amacrine cell differentiation', 'anterior/posterior pattern specification', 'artery morphogenesis', 'ascending aorta morphogenesis', 'BMP signaling pathway', 'Cajal-Retzius cell differentiation', 'cardiac neural crest cell development involved in outflow tract morphogenesis', 'cell adhesion', 'cell fate determination', 'cell maturation', 'cell migration', 'cell morphogenesis involved in neuron differentiation', 'cellular response to fatty acid', 'cellular response to interleukin-1', 'cellular response to nerve growth factor stimulus', 'cellular response to tumor necrosis factor', 'cochlea development', 'comma-shaped body morphogenesis', 'common bile duct development', 'embryonic heart tube morphogenesis', 'establishment of epithelial cell polarity', 'forebrain radial glial cell differentiation', 'glomerulus vasculature development', 'hindbrain morphogenesis', 'inner ear auditory receptor cell differentiation', 'inner ear receptor cell stereocilium organization', 'labyrinthine layer blood vessel development', 'lateral inhibition', 'liver development', 'lung development', 'metanephric nephron tubule morphogenesis', 'midbrain development', 'midbrain-hindbrain boundary morphogenesis', 'negative regulation of amacrine cell differentiation', 'negative regulation of calcium ion import', 'negative regulation of cell fate determination', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of forebrain neuron differentiation', 'negative regulation of gene expression', 'negative regulation of glial cell proliferation', 'negative regulation of inner ear auditory receptor cell differentiation', 'negative regulation of neuron differentiation', 'negative regulation of neuron projection development', 'negative regulation of oligodendrocyte differentiation', 'negative regulation of pancreatic A cell differentiation', 'negative regulation of pro-B cell differentiation', 'negative regulation of stem cell differentiation', 'negative regulation of stomach neuroendocrine cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'nervous system development', 'neuronal stem cell population maintenance', 'Notch signaling pathway', 'oculomotor nerve development', 'outflow tract morphogenesis', 'pancreatic A cell differentiation', 'pharyngeal arch artery morphogenesis', 'positive regulation of astrocyte differentiation', 'positive regulation of BMP signaling pathway', 'positive regulation of cell population proliferation', 'positive regulation of DNA binding', 'positive regulation of gene expression', 'positive regulation of mitotic cell cycle, embryonic', 'positive regulation of Notch signaling pathway', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of T cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tyrosine phosphorylation of STAT protein', 'protein-containing complex assembly', 'regulation of epithelial cell proliferation', 'regulation of fat cell differentiation', 'regulation of neurogenesis', 'regulation of protein-containing complex assembly', 'regulation of receptor signaling pathway via JAK-STAT', 'regulation of secondary heart field cardioblast proliferation', 'regulation of timing of neuron differentiation', 'regulation of transcription by RNA polymerase II', 'renal interstitial fibroblast development', 'response to alkaloid', 'response to organic cyclic compound', 'response to thyroid hormone', 'S-shaped body morphogenesis', 'smoothened signaling pathway', 'somatic stem cell population maintenance', 'stomach neuroendocrine cell differentiation', 'T cell proliferation', 'telencephalon development', 'thymus development', 'trochlear nerve development', 'ureteric bud morphogenesis', 'vascular associated smooth muscle cell development', 'ventricular septum development', 'ventricular septum morphogenesis']
Defensin alpha-like protein 1
75
Defensin alpha-like protein 1
65
3.8
72
0.37
Q4JEI2Q4JEI2['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']
Tumor necrosis factor receptor superfamily member 10B
232
Tumor necrosis factor receptor superfamily member 10B
232
3.8
40
0.67
O14763O14763['activation of NF-kappaB-inducing kinase activity', 'apoptotic process', 'cell surface receptor signaling pathway', 'cellular response to mechanical stimulus', 'defense response to tumor cell', 'extrinsic apoptotic signaling pathway via death domain receptors', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'positive regulation of apoptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of apoptotic process', 'response to endoplasmic reticulum stress', 'TRAIL-activated apoptotic signaling pathway']['activation of NF-kappaB-inducing kinase activity', 'apoptotic process', 'cell surface receptor signaling pathway', 'cellular response to mechanical stimulus', 'defense response to tumor cell', 'extrinsic apoptotic signaling pathway via death domain receptors', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'positive regulation of apoptotic process', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'regulation of apoptotic process', 'response to endoplasmic reticulum stress', 'TRAIL-activated apoptotic signaling pathway']
C-C motif chemokine 5
33
C-C motif chemokine 5
33
5.9
72
0.24
P30882P30882['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'eosinophil chemotaxis', 'epithelial cell proliferation', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of cell death', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of macrophage apoptotic process', 'negative regulation of neuron death', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of chemokine (C-X-C motif) ligand 2 production', 'positive regulation of defense response to virus by host', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fever generation', 'positive regulation of gene expression', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of macrophage chemotaxis', 'positive regulation of mast cell chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of osteoclast differentiation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'protein kinase B signaling', 'pseudopodium assembly', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to cytokine', 'response to interferon-gamma', 'response to toxic substance', 'response to tumor necrosis factor', 'T-helper 1 cell diapedesis']['activation of phospholipase D activity', 'calcium ion transport', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'eosinophil chemotaxis', 'epithelial cell proliferation', 'exocytosis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'leukocyte cell-cell adhesion', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation by host of viral transcription', 'negative regulation of cell death', 'negative regulation of G protein-coupled receptor signaling pathway', 'negative regulation of macrophage apoptotic process', 'negative regulation of neuron death', 'negative regulation of T cell apoptotic process', 'negative regulation of viral genome replication', 'neutrophil activation', 'neutrophil chemotaxis', 'positive regulation of angiogenesis', 'positive regulation of calcium ion transport', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cellular biosynthetic process', 'positive regulation of chemokine (C-X-C motif) ligand 2 production', 'positive regulation of defense response to virus by host', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fever generation', 'positive regulation of gene expression', 'positive regulation of GTPase activity', 'positive regulation of homotypic cell-cell adhesion', 'positive regulation of macrophage chemotaxis', 'positive regulation of mast cell chemotaxis', 'positive regulation of monocyte chemotaxis', 'positive regulation of natural killer cell chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of osteoclast differentiation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of T cell apoptotic process', 'positive regulation of T cell chemotaxis', 'positive regulation of T cell migration', 'positive regulation of T cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'protein kinase B signaling', 'pseudopodium assembly', 'regulation of insulin secretion', 'regulation of neuron death', 'regulation of T cell activation', 'response to cytokine', 'response to interferon-gamma', 'response to toxic substance', 'response to tumor necrosis factor', 'T-helper 1 cell diapedesis']
Coagulation factor XI
339
Coagulation factor XI
339
2.0
100
0.49
P03951P03951['blood coagulation', 'blood coagulation, intrinsic pathway', 'plasminogen activation', 'positive regulation of fibrinolysis', 'proteolysis', 'zymogen activation']['blood coagulation', 'blood coagulation, intrinsic pathway', 'plasminogen activation', 'positive regulation of fibrinolysis', 'proteolysis', 'zymogen activation']
T-cell surface glycoprotein CD8 alpha chain
217
Tyrosine-protein kinase Lck
23
3.8
34
0.77
P01732P06239['adaptive immune response', 'antigen processing and presentation', 'cell surface receptor signaling pathway', 'cytotoxic T cell differentiation', 'immune response', 'T cell activation', 'T cell mediated immunity', 'T cell receptor signaling pathway', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'B cell receptor signaling pathway', 'cell differentiation', 'cellular zinc ion homeostasis', 'Fc-gamma receptor signaling pathway', 'hemopoiesis', 'innate immune response', 'intracellular signal transduction', 'leukocyte migration', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'platelet activation', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of leukocyte cell-cell adhesion', 'positive regulation of T cell activation', 'positive regulation of T cell receptor signaling pathway', 'protein phosphorylation', 'regulation of lymphocyte activation', 'release of sequestered calcium ion into cytosol', 'response to xenobiotic stimulus', 'T cell costimulation', 'T cell differentiation', 'T cell receptor signaling pathway', 'transmembrane receptor protein tyrosine kinase signaling pathway']
T-cell surface glycoprotein CD4
447
Tyrosine-protein kinase Lck
20
3.8
35
0.75
P01730P06239['adaptive immune response', 'calcium-mediated signaling', 'cell adhesion', 'cell surface receptor signaling pathway', 'cellular response to granulocyte macrophage colony-stimulating factor stimulus', 'defense response to Gram-negative bacterium', 'enzyme-linked receptor protein signaling pathway', 'helper T cell enhancement of adaptive immune response', 'immune response', 'interleukin-15-mediated signaling pathway', 'macrophage differentiation', 'maintenance of protein location in cell', 'peptidyl-tyrosine phosphorylation', 'positive regulation of calcium-mediated signaling', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interleukin-2 production', 'positive regulation of kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of monocyte differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase activity', 'positive regulation of protein phosphorylation', 'positive regulation of T cell activation', 'positive regulation of transcription, DNA-templated', 'positive regulation of viral entry into host cell', 'regulation of calcium ion transport', 'regulation of T cell activation', 'signal transduction', 'T cell activation', 'T cell differentiation', 'T cell selection', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'B cell receptor signaling pathway', 'cell differentiation', 'cellular zinc ion homeostasis', 'Fc-gamma receptor signaling pathway', 'hemopoiesis', 'innate immune response', 'intracellular signal transduction', 'leukocyte migration', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'platelet activation', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of leukocyte cell-cell adhesion', 'positive regulation of T cell activation', 'positive regulation of T cell receptor signaling pathway', 'protein phosphorylation', 'regulation of lymphocyte activation', 'release of sequestered calcium ion into cytosol', 'response to xenobiotic stimulus', 'T cell costimulation', 'T cell differentiation', 'T cell receptor signaling pathway', 'transmembrane receptor protein tyrosine kinase signaling pathway']
T-cell surface glycoprotein CD4
447
Tyrosine-protein kinase Lck
23
3.8
32
0.82
P01730P06239['adaptive immune response', 'calcium-mediated signaling', 'cell adhesion', 'cell surface receptor signaling pathway', 'cellular response to granulocyte macrophage colony-stimulating factor stimulus', 'defense response to Gram-negative bacterium', 'enzyme-linked receptor protein signaling pathway', 'helper T cell enhancement of adaptive immune response', 'immune response', 'interleukin-15-mediated signaling pathway', 'macrophage differentiation', 'maintenance of protein location in cell', 'peptidyl-tyrosine phosphorylation', 'positive regulation of calcium-mediated signaling', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interleukin-2 production', 'positive regulation of kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of monocyte differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase activity', 'positive regulation of protein phosphorylation', 'positive regulation of T cell activation', 'positive regulation of transcription, DNA-templated', 'positive regulation of viral entry into host cell', 'regulation of calcium ion transport', 'regulation of T cell activation', 'signal transduction', 'T cell activation', 'T cell differentiation', 'T cell selection', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'B cell receptor signaling pathway', 'cell differentiation', 'cellular zinc ion homeostasis', 'Fc-gamma receptor signaling pathway', 'hemopoiesis', 'innate immune response', 'intracellular signal transduction', 'leukocyte migration', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'platelet activation', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of leukocyte cell-cell adhesion', 'positive regulation of T cell activation', 'positive regulation of T cell receptor signaling pathway', 'protein phosphorylation', 'regulation of lymphocyte activation', 'release of sequestered calcium ion into cytosol', 'response to xenobiotic stimulus', 'T cell costimulation', 'T cell differentiation', 'T cell receptor signaling pathway', 'transmembrane receptor protein tyrosine kinase signaling pathway']
T-cell surface glycoprotein CD4
445
Tyrosine-protein kinase Lck
20
3.8
40
0.65
P01730P06239['adaptive immune response', 'calcium-mediated signaling', 'cell adhesion', 'cell surface receptor signaling pathway', 'cellular response to granulocyte macrophage colony-stimulating factor stimulus', 'defense response to Gram-negative bacterium', 'enzyme-linked receptor protein signaling pathway', 'helper T cell enhancement of adaptive immune response', 'immune response', 'interleukin-15-mediated signaling pathway', 'macrophage differentiation', 'maintenance of protein location in cell', 'peptidyl-tyrosine phosphorylation', 'positive regulation of calcium-mediated signaling', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interleukin-2 production', 'positive regulation of kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of monocyte differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase activity', 'positive regulation of protein phosphorylation', 'positive regulation of T cell activation', 'positive regulation of transcription, DNA-templated', 'positive regulation of viral entry into host cell', 'regulation of calcium ion transport', 'regulation of T cell activation', 'signal transduction', 'T cell activation', 'T cell differentiation', 'T cell selection', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'B cell receptor signaling pathway', 'cell differentiation', 'cellular zinc ion homeostasis', 'Fc-gamma receptor signaling pathway', 'hemopoiesis', 'innate immune response', 'intracellular signal transduction', 'leukocyte migration', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'platelet activation', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of leukocyte cell-cell adhesion', 'positive regulation of T cell activation', 'positive regulation of T cell receptor signaling pathway', 'protein phosphorylation', 'regulation of lymphocyte activation', 'release of sequestered calcium ion into cytosol', 'response to xenobiotic stimulus', 'T cell costimulation', 'T cell differentiation', 'T cell receptor signaling pathway', 'transmembrane receptor protein tyrosine kinase signaling pathway']
T-cell surface glycoprotein CD8 alpha chain
215
Tyrosine-protein kinase Lck
20
3.9
44
0.59
P01732P06239['adaptive immune response', 'antigen processing and presentation', 'cell surface receptor signaling pathway', 'cytotoxic T cell differentiation', 'immune response', 'T cell activation', 'T cell mediated immunity', 'T cell receptor signaling pathway', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'B cell receptor signaling pathway', 'cell differentiation', 'cellular zinc ion homeostasis', 'Fc-gamma receptor signaling pathway', 'hemopoiesis', 'innate immune response', 'intracellular signal transduction', 'leukocyte migration', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'platelet activation', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of leukocyte cell-cell adhesion', 'positive regulation of T cell activation', 'positive regulation of T cell receptor signaling pathway', 'protein phosphorylation', 'regulation of lymphocyte activation', 'release of sequestered calcium ion into cytosol', 'response to xenobiotic stimulus', 'T cell costimulation', 'T cell differentiation', 'T cell receptor signaling pathway', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Insulin-like 3
129
Insulin-like 3
46
2.0
48
1.02
P51460P51460['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'cell-cell signaling', 'male gonad development', 'negative regulation of apoptotic process', 'negative regulation of cell population proliferation', 'oocyte maturation', 'positive regulation of cAMP-mediated signaling', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of wound healing', 'spermatogenesis']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'cell-cell signaling', 'male gonad development', 'negative regulation of apoptotic process', 'negative regulation of cell population proliferation', 'oocyte maturation', 'positive regulation of cAMP-mediated signaling', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of wound healing', 'spermatogenesis']
Transcription factor HES-1
128
Transcription factor HES-1
128
3.8
54
0.48
Q14469Q14469['adenohypophysis development', 'amacrine cell differentiation', 'anterior/posterior pattern specification', 'artery morphogenesis', 'ascending aorta morphogenesis', 'BMP signaling pathway', 'Cajal-Retzius cell differentiation', 'cardiac neural crest cell development involved in outflow tract morphogenesis', 'cell adhesion', 'cell fate determination', 'cell maturation', 'cell migration', 'cell morphogenesis involved in neuron differentiation', 'cellular response to fatty acid', 'cellular response to interleukin-1', 'cellular response to nerve growth factor stimulus', 'cellular response to tumor necrosis factor', 'cochlea development', 'comma-shaped body morphogenesis', 'common bile duct development', 'embryonic heart tube morphogenesis', 'establishment of epithelial cell polarity', 'forebrain radial glial cell differentiation', 'glomerulus vasculature development', 'hindbrain morphogenesis', 'inner ear auditory receptor cell differentiation', 'inner ear receptor cell stereocilium organization', 'labyrinthine layer blood vessel development', 'lateral inhibition', 'liver development', 'lung development', 'metanephric nephron tubule morphogenesis', 'midbrain development', 'midbrain-hindbrain boundary morphogenesis', 'negative regulation of amacrine cell differentiation', 'negative regulation of calcium ion import', 'negative regulation of cell fate determination', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of forebrain neuron differentiation', 'negative regulation of gene expression', 'negative regulation of glial cell proliferation', 'negative regulation of inner ear auditory receptor cell differentiation', 'negative regulation of neuron differentiation', 'negative regulation of neuron projection development', 'negative regulation of oligodendrocyte differentiation', 'negative regulation of pancreatic A cell differentiation', 'negative regulation of pro-B cell differentiation', 'negative regulation of stem cell differentiation', 'negative regulation of stomach neuroendocrine cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'nervous system development', 'neuronal stem cell population maintenance', 'Notch signaling pathway', 'oculomotor nerve development', 'outflow tract morphogenesis', 'pancreatic A cell differentiation', 'pharyngeal arch artery morphogenesis', 'positive regulation of astrocyte differentiation', 'positive regulation of BMP signaling pathway', 'positive regulation of cell population proliferation', 'positive regulation of DNA binding', 'positive regulation of gene expression', 'positive regulation of mitotic cell cycle, embryonic', 'positive regulation of Notch signaling pathway', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of T cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tyrosine phosphorylation of STAT protein', 'protein-containing complex assembly', 'regulation of epithelial cell proliferation', 'regulation of fat cell differentiation', 'regulation of neurogenesis', 'regulation of protein-containing complex assembly', 'regulation of receptor signaling pathway via JAK-STAT', 'regulation of secondary heart field cardioblast proliferation', 'regulation of timing of neuron differentiation', 'regulation of transcription by RNA polymerase II', 'renal interstitial fibroblast development', 'response to alkaloid', 'response to organic cyclic compound', 'response to thyroid hormone', 'S-shaped body morphogenesis', 'smoothened signaling pathway', 'somatic stem cell population maintenance', 'stomach neuroendocrine cell differentiation', 'T cell proliferation', 'telencephalon development', 'thymus development', 'trochlear nerve development', 'ureteric bud morphogenesis', 'vascular associated smooth muscle cell development', 'ventricular septum development', 'ventricular septum morphogenesis']['adenohypophysis development', 'amacrine cell differentiation', 'anterior/posterior pattern specification', 'artery morphogenesis', 'ascending aorta morphogenesis', 'BMP signaling pathway', 'Cajal-Retzius cell differentiation', 'cardiac neural crest cell development involved in outflow tract morphogenesis', 'cell adhesion', 'cell fate determination', 'cell maturation', 'cell migration', 'cell morphogenesis involved in neuron differentiation', 'cellular response to fatty acid', 'cellular response to interleukin-1', 'cellular response to nerve growth factor stimulus', 'cellular response to tumor necrosis factor', 'cochlea development', 'comma-shaped body morphogenesis', 'common bile duct development', 'embryonic heart tube morphogenesis', 'establishment of epithelial cell polarity', 'forebrain radial glial cell differentiation', 'glomerulus vasculature development', 'hindbrain morphogenesis', 'inner ear auditory receptor cell differentiation', 'inner ear receptor cell stereocilium organization', 'labyrinthine layer blood vessel development', 'lateral inhibition', 'liver development', 'lung development', 'metanephric nephron tubule morphogenesis', 'midbrain development', 'midbrain-hindbrain boundary morphogenesis', 'negative regulation of amacrine cell differentiation', 'negative regulation of calcium ion import', 'negative regulation of cell fate determination', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of forebrain neuron differentiation', 'negative regulation of gene expression', 'negative regulation of glial cell proliferation', 'negative regulation of inner ear auditory receptor cell differentiation', 'negative regulation of neuron differentiation', 'negative regulation of neuron projection development', 'negative regulation of oligodendrocyte differentiation', 'negative regulation of pancreatic A cell differentiation', 'negative regulation of pro-B cell differentiation', 'negative regulation of stem cell differentiation', 'negative regulation of stomach neuroendocrine cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'nervous system development', 'neuronal stem cell population maintenance', 'Notch signaling pathway', 'oculomotor nerve development', 'outflow tract morphogenesis', 'pancreatic A cell differentiation', 'pharyngeal arch artery morphogenesis', 'positive regulation of astrocyte differentiation', 'positive regulation of BMP signaling pathway', 'positive regulation of cell population proliferation', 'positive regulation of DNA binding', 'positive regulation of gene expression', 'positive regulation of mitotic cell cycle, embryonic', 'positive regulation of Notch signaling pathway', 'positive regulation of receptor signaling pathway via JAK-STAT', 'positive regulation of T cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tyrosine phosphorylation of STAT protein', 'protein-containing complex assembly', 'regulation of epithelial cell proliferation', 'regulation of fat cell differentiation', 'regulation of neurogenesis', 'regulation of protein-containing complex assembly', 'regulation of receptor signaling pathway via JAK-STAT', 'regulation of secondary heart field cardioblast proliferation', 'regulation of timing of neuron differentiation', 'regulation of transcription by RNA polymerase II', 'renal interstitial fibroblast development', 'response to alkaloid', 'response to organic cyclic compound', 'response to thyroid hormone', 'S-shaped body morphogenesis', 'smoothened signaling pathway', 'somatic stem cell population maintenance', 'stomach neuroendocrine cell differentiation', 'T cell proliferation', 'telencephalon development', 'thymus development', 'trochlear nerve development', 'ureteric bud morphogenesis', 'vascular associated smooth muscle cell development', 'ventricular septum development', 'ventricular septum morphogenesis']
Stromal cell-derived factor 1
65
Stromal cell-derived factor 1
236
2.0
78
0.63
P48061P48061['adult locomotory behavior', 'animal organ regeneration', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'axon guidance', 'blood circulation', 'cell adhesion', 'cell chemotaxis', 'cellular calcium ion homeostasis', 'cellular response to chemokine', 'chemokine (C-X-C motif) ligand 12 signaling pathway', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response', 'detection of mechanical stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in sensory perception of pain', 'G protein-coupled receptor signaling pathway', 'immune response', 'induction of positive chemotaxis', 'integrin activation', 'killing of cells of another organism', 'negative regulation of dendritic cell apoptotic process', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of leukocyte tethering or rolling', 'neuron migration', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of calcium ion import', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of dopamine secretion', 'positive regulation of endothelial cell proliferation', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of T cell migration', 'regulation of actin polymerization or depolymerization', 'response to heat', 'response to hypoxia', 'response to peptide hormone', 'response to radiation', 'response to ultrasound', 'response to virus', 'signal transduction', 'T cell chemotaxis', 'telencephalon cell migration']['adult locomotory behavior', 'animal organ regeneration', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'axon guidance', 'blood circulation', 'cell adhesion', 'cell chemotaxis', 'cellular calcium ion homeostasis', 'cellular response to chemokine', 'chemokine (C-X-C motif) ligand 12 signaling pathway', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response', 'detection of mechanical stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in sensory perception of pain', 'G protein-coupled receptor signaling pathway', 'immune response', 'induction of positive chemotaxis', 'integrin activation', 'killing of cells of another organism', 'negative regulation of dendritic cell apoptotic process', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of leukocyte tethering or rolling', 'neuron migration', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of calcium ion import', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of dopamine secretion', 'positive regulation of endothelial cell proliferation', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of T cell migration', 'regulation of actin polymerization or depolymerization', 'response to heat', 'response to hypoxia', 'response to peptide hormone', 'response to radiation', 'response to ultrasound', 'response to virus', 'signal transduction', 'T cell chemotaxis', 'telencephalon cell migration']
Stromal cell-derived factor 1
36
Stromal cell-derived factor 1
265
2.0
73
0.67
P48061P48061['adult locomotory behavior', 'animal organ regeneration', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'axon guidance', 'blood circulation', 'cell adhesion', 'cell chemotaxis', 'cellular calcium ion homeostasis', 'cellular response to chemokine', 'chemokine (C-X-C motif) ligand 12 signaling pathway', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response', 'detection of mechanical stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in sensory perception of pain', 'G protein-coupled receptor signaling pathway', 'immune response', 'induction of positive chemotaxis', 'integrin activation', 'killing of cells of another organism', 'negative regulation of dendritic cell apoptotic process', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of leukocyte tethering or rolling', 'neuron migration', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of calcium ion import', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of dopamine secretion', 'positive regulation of endothelial cell proliferation', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of T cell migration', 'regulation of actin polymerization or depolymerization', 'response to heat', 'response to hypoxia', 'response to peptide hormone', 'response to radiation', 'response to ultrasound', 'response to virus', 'signal transduction', 'T cell chemotaxis', 'telencephalon cell migration']['adult locomotory behavior', 'animal organ regeneration', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'axon guidance', 'blood circulation', 'cell adhesion', 'cell chemotaxis', 'cellular calcium ion homeostasis', 'cellular response to chemokine', 'chemokine (C-X-C motif) ligand 12 signaling pathway', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response', 'detection of mechanical stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in sensory perception of pain', 'G protein-coupled receptor signaling pathway', 'immune response', 'induction of positive chemotaxis', 'integrin activation', 'killing of cells of another organism', 'negative regulation of dendritic cell apoptotic process', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of leukocyte tethering or rolling', 'neuron migration', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of calcium ion import', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of dopamine secretion', 'positive regulation of endothelial cell proliferation', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of T cell migration', 'regulation of actin polymerization or depolymerization', 'response to heat', 'response to hypoxia', 'response to peptide hormone', 'response to radiation', 'response to ultrasound', 'response to virus', 'signal transduction', 'T cell chemotaxis', 'telencephalon cell migration']
Stromal cell-derived factor 1
65
Stromal cell-derived factor 1
265
9.9
65
0.16
P48061P48061['adult locomotory behavior', 'animal organ regeneration', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'axon guidance', 'blood circulation', 'cell adhesion', 'cell chemotaxis', 'cellular calcium ion homeostasis', 'cellular response to chemokine', 'chemokine (C-X-C motif) ligand 12 signaling pathway', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response', 'detection of mechanical stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in sensory perception of pain', 'G protein-coupled receptor signaling pathway', 'immune response', 'induction of positive chemotaxis', 'integrin activation', 'killing of cells of another organism', 'negative regulation of dendritic cell apoptotic process', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of leukocyte tethering or rolling', 'neuron migration', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of calcium ion import', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of dopamine secretion', 'positive regulation of endothelial cell proliferation', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of T cell migration', 'regulation of actin polymerization or depolymerization', 'response to heat', 'response to hypoxia', 'response to peptide hormone', 'response to radiation', 'response to ultrasound', 'response to virus', 'signal transduction', 'T cell chemotaxis', 'telencephalon cell migration']['adult locomotory behavior', 'animal organ regeneration', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'axon guidance', 'blood circulation', 'cell adhesion', 'cell chemotaxis', 'cellular calcium ion homeostasis', 'cellular response to chemokine', 'chemokine (C-X-C motif) ligand 12 signaling pathway', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response', 'detection of mechanical stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in sensory perception of pain', 'G protein-coupled receptor signaling pathway', 'immune response', 'induction of positive chemotaxis', 'integrin activation', 'killing of cells of another organism', 'negative regulation of dendritic cell apoptotic process', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of leukocyte tethering or rolling', 'neuron migration', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of calcium ion import', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of dopamine secretion', 'positive regulation of endothelial cell proliferation', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of T cell migration', 'regulation of actin polymerization or depolymerization', 'response to heat', 'response to hypoxia', 'response to peptide hormone', 'response to radiation', 'response to ultrasound', 'response to virus', 'signal transduction', 'T cell chemotaxis', 'telencephalon cell migration']
Transcription factor Jun
273
Transcription factor Jun
273
2.0
nan
nan
P05412P05412['angiogenesis', 'apoptotic process', 'axon regeneration', 'cell population proliferation', 'cellular response to anisomycin', 'cellular response to cadmium ion', 'cellular response to calcium ion', 'cellular response to reactive oxygen species', 'eyelid development in camera-type eye', 'integrated stress response signaling', 'leading edge cell differentiation', 'liver development', 'microglial cell activation', 'monocyte differentiation', 'negative regulation by host of viral transcription', 'negative regulation of cell population proliferation', 'negative regulation of DNA binding', 'negative regulation of neuron apoptotic process', 'negative regulation of protein autophosphorylation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress', 'negative regulation of transcription, DNA-templated', 'outflow tract morphogenesis', 'positive regulation by host of viral transcription', 'positive regulation of apoptotic process', 'positive regulation of DNA-templated transcription, initiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of miRNA transcription', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular associated smooth muscle cell proliferation', 'Ras protein signal transduction', 'regulation of cell cycle', 'regulation of cell population proliferation', 'regulation of transcription by RNA polymerase II', 'response to muscle stretch', 'response to xenobiotic stimulus', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']['angiogenesis', 'apoptotic process', 'axon regeneration', 'cell population proliferation', 'cellular response to anisomycin', 'cellular response to cadmium ion', 'cellular response to calcium ion', 'cellular response to reactive oxygen species', 'eyelid development in camera-type eye', 'integrated stress response signaling', 'leading edge cell differentiation', 'liver development', 'microglial cell activation', 'monocyte differentiation', 'negative regulation by host of viral transcription', 'negative regulation of cell population proliferation', 'negative regulation of DNA binding', 'negative regulation of neuron apoptotic process', 'negative regulation of protein autophosphorylation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress', 'negative regulation of transcription, DNA-templated', 'outflow tract morphogenesis', 'positive regulation by host of viral transcription', 'positive regulation of apoptotic process', 'positive regulation of DNA-templated transcription, initiation', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of miRNA transcription', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular associated smooth muscle cell proliferation', 'Ras protein signal transduction', 'regulation of cell cycle', 'regulation of cell population proliferation', 'regulation of transcription by RNA polymerase II', 'response to muscle stretch', 'response to xenobiotic stimulus', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway']
DNA fragmentation factor subunit beta
10
DNA fragmentation factor subunit alpha
78
5.2
66
0.29
O54788O54786['apoptotic chromosome condensation', 'apoptotic DNA fragmentation', 'DNA catabolic process', 'negative regulation of apoptotic DNA fragmentation']['apoptotic DNA fragmentation', 'chaperone-mediated protein folding', 'negative regulation of apoptotic DNA fragmentation', 'negative regulation of deoxyribonuclease activity', 'negative regulation of execution phase of apoptosis', 'positive regulation of apoptotic process', 'regulation of apoptotic process', 'thymocyte apoptotic process']
Integrin alpha-IIb
962
Integrin beta-3
488
2.0
42
1.18
P08514P05106['angiogenesis', 'cell adhesion mediated by integrin', 'cell-cell adhesion', 'cell-matrix adhesion', 'integrin-mediated signaling pathway']['activation of protein kinase activity', 'angiogenesis involved in wound healing', 'apolipoprotein A-I-mediated signaling pathway', 'apoptotic cell clearance', 'blood coagulation', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-matrix adhesion', 'cell-substrate adhesion', 'cell-substrate junction assembly', 'cellular response to insulin-like growth factor stimulus', 'cellular response to mechanical stimulus', 'cellular response to platelet-derived growth factor stimulus', 'cellular response to xenobiotic stimulus', 'embryo implantation', 'heterotypic cell-cell adhesion', 'integrin-mediated signaling pathway', 'mesodermal cell differentiation', 'negative chemotaxis', 'negative regulation of cell death', 'negative regulation of lipid storage', 'negative regulation of lipid transport', 'negative regulation of lipoprotein metabolic process', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of macrophage derived foam cell differentiation', 'platelet activation', 'platelet aggregation', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway', 'positive regulation of angiogenesis', 'positive regulation of bone resorption', 'positive regulation of cell adhesion mediated by integrin', 'positive regulation of cell-matrix adhesion', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of osteoblast proliferation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein phosphorylation', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of T cell migration', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of actin cytoskeleton organization', 'regulation of bone resorption', 'regulation of extracellular matrix organization', 'regulation of postsynaptic neurotransmitter receptor internalization', 'regulation of protein localization', 'regulation of protein tyrosine kinase activity', 'regulation of release of sequestered calcium ion into cytosol', 'regulation of serotonin uptake', 'regulation of trophoblast cell migration', 'response to activity', 'response to radiation', 'smooth muscle cell migration', 'substrate adhesion-dependent cell spreading', 'tube development', 'viral entry into host cell', 'wound healing']
SAM and SH3 domain-containing protein 3
68
SAM and SH3 domain-containing protein 3
68
2.0
28
1.76
Q8K352Q8K352['B cell homeostasis', 'B cell proliferation', 'CD4-positive, alpha-beta T cell differentiation', 'homeostasis of number of cells within a tissue', 'positive regulation of adaptive immune response', 'positive regulation of B cell proliferation', 'positive regulation of CD4-positive, alpha-beta T cell differentiation', 'positive regulation of immunoglobulin production', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-10 production', 'positive regulation of interleukin-2 production', 'positive regulation of interleukin-4 production', 'positive regulation of lymphocyte activation', 'positive regulation of organ growth', 'positive regulation of T cell cytokine production', 'positive regulation of T cell proliferation', 'positive regulation of tumor necrosis factor production', 'T cell proliferation']['B cell homeostasis', 'B cell proliferation', 'CD4-positive, alpha-beta T cell differentiation', 'homeostasis of number of cells within a tissue', 'positive regulation of adaptive immune response', 'positive regulation of B cell proliferation', 'positive regulation of CD4-positive, alpha-beta T cell differentiation', 'positive regulation of immunoglobulin production', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-10 production', 'positive regulation of interleukin-2 production', 'positive regulation of interleukin-4 production', 'positive regulation of lymphocyte activation', 'positive regulation of organ growth', 'positive regulation of T cell cytokine production', 'positive regulation of T cell proliferation', 'positive regulation of tumor necrosis factor production', 'T cell proliferation']
Integrin alpha-IIb
963
Integrin beta-3
630
2.0
40
1.24
P08514P05106['angiogenesis', 'cell adhesion mediated by integrin', 'cell-cell adhesion', 'cell-matrix adhesion', 'integrin-mediated signaling pathway']['activation of protein kinase activity', 'angiogenesis involved in wound healing', 'apolipoprotein A-I-mediated signaling pathway', 'apoptotic cell clearance', 'blood coagulation', 'cell adhesion', 'cell adhesion mediated by integrin', 'cell migration', 'cell-matrix adhesion', 'cell-substrate adhesion', 'cell-substrate junction assembly', 'cellular response to insulin-like growth factor stimulus', 'cellular response to mechanical stimulus', 'cellular response to platelet-derived growth factor stimulus', 'cellular response to xenobiotic stimulus', 'embryo implantation', 'heterotypic cell-cell adhesion', 'integrin-mediated signaling pathway', 'mesodermal cell differentiation', 'negative chemotaxis', 'negative regulation of cell death', 'negative regulation of lipid storage', 'negative regulation of lipid transport', 'negative regulation of lipoprotein metabolic process', 'negative regulation of low-density lipoprotein receptor activity', 'negative regulation of macrophage derived foam cell differentiation', 'platelet activation', 'platelet aggregation', 'platelet-derived growth factor receptor signaling pathway', 'positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway', 'positive regulation of angiogenesis', 'positive regulation of bone resorption', 'positive regulation of cell adhesion mediated by integrin', 'positive regulation of cell-matrix adhesion', 'positive regulation of endothelial cell migration', 'positive regulation of endothelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast migration', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glomerular mesangial cell proliferation', 'positive regulation of osteoblast proliferation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein phosphorylation', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of substrate adhesion-dependent cell spreading', 'positive regulation of T cell migration', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of actin cytoskeleton organization', 'regulation of bone resorption', 'regulation of extracellular matrix organization', 'regulation of postsynaptic neurotransmitter receptor internalization', 'regulation of protein localization', 'regulation of protein tyrosine kinase activity', 'regulation of release of sequestered calcium ion into cytosol', 'regulation of serotonin uptake', 'regulation of trophoblast cell migration', 'response to activity', 'response to radiation', 'smooth muscle cell migration', 'substrate adhesion-dependent cell spreading', 'tube development', 'viral entry into host cell', 'wound healing']
Cytoplasmic dynein 1 intermediate chain 2
284
Cytoplasmic dynein 1 intermediate chain 2
212
9.9
71
0.14
Q13409Q13409['microtubule-based movement', 'transport along microtubule']['microtubule-based movement', 'transport along microtubule']
55 kDa erythrocyte membrane protein
85
Glycophorin-C
nan
2.0
61
0.81
Q00013P04921['regulation of neutrophil chemotaxis', 'signal transduction'][]
Tropomyosin alpha-1 chain
249
Tropomyosin alpha-1 chain
249
4.7
36
0.59
1
✔Q63609Q63609['actin filament capping', 'actin filament organization', 'cardiac muscle contraction', 'cellular response to reactive oxygen species', 'in utero embryonic development', 'muscle contraction', 'muscle filament sliding', 'negative regulation of cell migration', 'negative regulation of vascular associated smooth muscle cell migration', 'negative regulation of vascular associated smooth muscle cell proliferation', 'positive regulation of ATP-dependent activity', 'positive regulation of cell adhesion', 'positive regulation of heart rate by epinephrine', 'positive regulation of stress fiber assembly', 'regulation of ATP-dependent activity', 'regulation of cell shape', 'ruffle organization', 'sarcomere organization', 'ventricular cardiac muscle tissue morphogenesis', 'wound healing']['actin filament capping', 'actin filament organization', 'cardiac muscle contraction', 'cellular response to reactive oxygen species', 'in utero embryonic development', 'muscle contraction', 'muscle filament sliding', 'negative regulation of cell migration', 'negative regulation of vascular associated smooth muscle cell migration', 'negative regulation of vascular associated smooth muscle cell proliferation', 'positive regulation of ATP-dependent activity', 'positive regulation of cell adhesion', 'positive regulation of heart rate by epinephrine', 'positive regulation of stress fiber assembly', 'regulation of ATP-dependent activity', 'regulation of cell shape', 'ruffle organization', 'sarcomere organization', 'ventricular cardiac muscle tissue morphogenesis', 'wound healing']
Tropomyosin alpha-1 chain
249
Tropomyosin alpha-1 chain
249
1.8
37
1.47
1
✔P04692P04692['actin filament capping', 'actin filament organization', 'cardiac muscle contraction', 'cellular response to reactive oxygen species', 'in utero embryonic development', 'muscle contraction', 'muscle filament sliding', 'negative regulation of cell migration', 'negative regulation of vascular associated smooth muscle cell migration', 'negative regulation of vascular associated smooth muscle cell proliferation', 'positive regulation of ATP-dependent activity', 'positive regulation of cell adhesion', 'positive regulation of heart rate by epinephrine', 'positive regulation of stress fiber assembly', 'regulation of ATP-dependent activity', 'regulation of cell shape', 'ruffle organization', 'sarcomere organization', 'ventricular cardiac muscle tissue morphogenesis', 'wound healing']['actin filament capping', 'actin filament organization', 'cardiac muscle contraction', 'cellular response to reactive oxygen species', 'in utero embryonic development', 'muscle contraction', 'muscle filament sliding', 'negative regulation of cell migration', 'negative regulation of vascular associated smooth muscle cell migration', 'negative regulation of vascular associated smooth muscle cell proliferation', 'positive regulation of ATP-dependent activity', 'positive regulation of cell adhesion', 'positive regulation of heart rate by epinephrine', 'positive regulation of stress fiber assembly', 'regulation of ATP-dependent activity', 'regulation of cell shape', 'ruffle organization', 'sarcomere organization', 'ventricular cardiac muscle tissue morphogenesis', 'wound healing']
Transmembrane emp24 domain-containing protein 10
1
Transmembrane emp24 domain-containing protein 10
1
2.0
nan
nan
Q28735Q28735['COPI-coated vesicle budding', 'cytosol to ERGIC protein transport', 'positive regulation of interleukin-1 production', 'positive regulation of protein secretion', 'protein localization to ERGIC', 'regulation of amyloid-beta formation', 'retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum']['COPI-coated vesicle budding', 'cytosol to ERGIC protein transport', 'positive regulation of interleukin-1 production', 'positive regulation of protein secretion', 'protein localization to ERGIC', 'regulation of amyloid-beta formation', 'retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum']
Protein max
nan
Protein max
nan
2.0
nan
nan
P61244P61244['cellular response to peptide hormone stimulus', 'cellular response to starvation', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein-containing complex assembly', 'regulation of transcription by RNA polymerase II', 'response to axon injury', 'response to insulin', 'retina development in camera-type eye']['cellular response to peptide hormone stimulus', 'cellular response to starvation', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein-containing complex assembly', 'regulation of transcription by RNA polymerase II', 'response to axon injury', 'response to insulin', 'retina development in camera-type eye']
Myc proto-oncogene protein
3
Protein max
nan
2.0
nan
nan
P01106P28574['branching involved in ureteric bud morphogenesis', 'cellular iron ion homeostasis', 'cellular response to DNA damage stimulus', 'cellular response to hypoxia', 'cellular response to UV', 'cellular response to xenobiotic stimulus', 'chromatin remodeling', 'chromosome organization', 'energy reserve metabolic process', 'ERK1 and ERK2 cascade', 'fibroblast apoptotic process', 'G1/S transition of mitotic cell cycle', 'MAPK cascade', 'negative regulation of apoptotic process', 'negative regulation of cell division', 'negative regulation of fibroblast proliferation', 'negative regulation of monocyte differentiation', 'negative regulation of stress-activated MAPK cascade', 'negative regulation of transcription by RNA polymerase II', 'oxygen transport', 'positive regulation of cell population proliferation', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of DNA biosynthetic process', 'positive regulation of DNA methylation', 'positive regulation of epithelial cell proliferation', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator', 'positive regulation of mesenchymal cell proliferation', 'positive regulation of metanephric cap mesenchymal cell proliferation', 'positive regulation of miRNA transcription', 'positive regulation of response to DNA damage stimulus', 'positive regulation of telomerase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein-DNA complex disassembly', 'regulation of cell cycle process', 'regulation of gene expression', 'regulation of somatic stem cell population maintenance', 'regulation of telomere maintenance', 'regulation of transcription by RNA polymerase II', 'response to gamma radiation', 'response to growth factor', 'response to xenobiotic stimulus']['cellular response to peptide hormone stimulus', 'cellular response to starvation', 'negative regulation of gene expression', 'negative regulation of transcription by RNA polymerase II', 'neuron apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein-containing complex assembly', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to axon injury', 'response to insulin', 'retina development in camera-type eye']
Cytoplasmic dynein 1 intermediate chain 2
69
Cytoplasmic dynein 1 intermediate chain 2
284
9.9
70
0.14
Q13409Q13409['microtubule-based movement', 'transport along microtubule']['microtubule-based movement', 'transport along microtubule']
T-cell surface glycoprotein CD4
445
Tyrosine-protein kinase Lck
23
3.8
37
0.71
P01730P06239['adaptive immune response', 'calcium-mediated signaling', 'cell adhesion', 'cell surface receptor signaling pathway', 'cellular response to granulocyte macrophage colony-stimulating factor stimulus', 'defense response to Gram-negative bacterium', 'enzyme-linked receptor protein signaling pathway', 'helper T cell enhancement of adaptive immune response', 'immune response', 'interleukin-15-mediated signaling pathway', 'macrophage differentiation', 'maintenance of protein location in cell', 'peptidyl-tyrosine phosphorylation', 'positive regulation of calcium-mediated signaling', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interleukin-2 production', 'positive regulation of kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of monocyte differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase activity', 'positive regulation of protein phosphorylation', 'positive regulation of T cell activation', 'positive regulation of transcription, DNA-templated', 'positive regulation of viral entry into host cell', 'regulation of calcium ion transport', 'regulation of T cell activation', 'signal transduction', 'T cell activation', 'T cell differentiation', 'T cell selection', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'B cell receptor signaling pathway', 'cell differentiation', 'cellular zinc ion homeostasis', 'Fc-gamma receptor signaling pathway', 'hemopoiesis', 'innate immune response', 'intracellular signal transduction', 'leukocyte migration', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'platelet activation', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of leukocyte cell-cell adhesion', 'positive regulation of T cell activation', 'positive regulation of T cell receptor signaling pathway', 'protein phosphorylation', 'regulation of lymphocyte activation', 'release of sequestered calcium ion into cytosol', 'response to xenobiotic stimulus', 'T cell costimulation', 'T cell differentiation', 'T cell receptor signaling pathway', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Receptor tyrosine-protein kinase erbB-2
642
Epidermal growth factor receptor
636
9.5
15
0.7
P04626P00533['cell surface receptor signaling pathway', 'cellular response to epidermal growth factor stimulus', 'cellular response to growth factor stimulus', 'enzyme-linked receptor protein signaling pathway', 'ERBB2-EGFR signaling pathway', 'ERBB2-ERBB3 signaling pathway', 'ERBB2-ERBB4 signaling pathway', 'heart development', 'immature T cell proliferation in thymus', 'intracellular signal transduction', 'motor neuron axon guidance', 'myelination', 'negative regulation of immature T cell proliferation in thymus', 'neuromuscular junction development', 'neuron differentiation', 'oligodendrocyte differentiation', 'peptidyl-tyrosine phosphorylation', 'peripheral nervous system development', 'phosphatidylinositol 3-kinase signaling', 'positive regulation of cell adhesion', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell proliferation', 'positive regulation of GTPase activity', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of protein phosphorylation', 'positive regulation of protein targeting to membrane', 'positive regulation of transcription by RNA polymerase I', 'positive regulation of translation', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of angiogenesis', 'regulation of ERK1 and ERK2 cascade', 'regulation of microtubule-based process', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'wound healing']['activation of phospholipase C activity', 'cell differentiation', 'cell morphogenesis', 'cell surface receptor signaling pathway', 'cell-cell adhesion', 'cellular response to amino acid stimulus', 'cellular response to cadmium ion', 'cellular response to epidermal growth factor stimulus', 'cellular response to estradiol stimulus', 'cellular response to reactive oxygen species', 'cerebral cortex cell migration', 'digestive tract morphogenesis', 'embryonic placenta development', 'epidermal growth factor receptor signaling pathway', 'epithelial cell proliferation', 'ERBB2-EGFR signaling pathway', 'eyelid development in camera-type eye', 'hair follicle development', 'learning or memory', 'morphogenesis of an epithelial fold', 'negative regulation of apoptotic process', 'negative regulation of cardiocyte differentiation', 'negative regulation of epidermal growth factor receptor signaling pathway', 'negative regulation of protein catabolic process', 'ossification', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cyclin-dependent protein serine/threonine kinase activity', 'positive regulation of DNA repair', 'positive regulation of DNA replication', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of G1/S transition of mitotic cell cycle', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of miRNA maturation', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein kinase C activity', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein phosphorylation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein insertion into membrane', 'regulation of ERK1 and ERK2 cascade', 'regulation of JNK cascade', 'regulation of nitric-oxide synthase activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of phosphatidylinositol 3-kinase signaling', 'response to UV-A', 'salivary gland morphogenesis', 'signal transduction', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Pancreatic trypsin inhibitor
73
Pancreatic trypsin inhibitor
73
9.2
nan
nan
P00974P00974['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']['negative regulation of platelet aggregation', 'negative regulation of serine-type endopeptidase activity', 'negative regulation of thrombin-activated receptor signaling pathway', 'trypsinogen activation']
TYRO protein tyrosine kinase-binding protein
35
TYRO protein tyrosine kinase-binding protein
35
2.0
nan
nan
O43914O43914['actin cytoskeleton organization', 'apoptotic cell clearance', 'apoptotic signaling pathway', 'cellular defense response', 'forebrain development', 'intracellular signal transduction', 'microglial cell activation involved in immune response', 'myeloid leukocyte activation', 'negative regulation of B cell proliferation', 'negative regulation of interleukin-10 production', 'negative regulation of long-term synaptic potentiation', 'negative regulation of transforming growth factor beta1 production', 'neutrophil activation involved in immune response', 'osteoclast differentiation', 'positive regulation of gene expression', 'positive regulation of hippocampal neuron apoptotic process', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of macrophage fusion', 'positive regulation of microglial cell mediated cytotoxicity', 'positive regulation of natural killer cell activation', 'positive regulation of neuron death', 'positive regulation of osteoclast development', 'positive regulation of protein localization to cell surface', 'positive regulation of receptor localization to synapse', 'positive regulation of superoxide anion generation', 'positive regulation of tumor necrosis factor production', 'protein stabilization', 'response to axon injury', 'signal transduction', 'stimulatory C-type lectin receptor signaling pathway', 'stimulatory killer cell immunoglobulin-like receptor signaling pathway']['actin cytoskeleton organization', 'apoptotic cell clearance', 'apoptotic signaling pathway', 'cellular defense response', 'forebrain development', 'intracellular signal transduction', 'microglial cell activation involved in immune response', 'myeloid leukocyte activation', 'negative regulation of B cell proliferation', 'negative regulation of interleukin-10 production', 'negative regulation of long-term synaptic potentiation', 'negative regulation of transforming growth factor beta1 production', 'neutrophil activation involved in immune response', 'osteoclast differentiation', 'positive regulation of gene expression', 'positive regulation of hippocampal neuron apoptotic process', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of macrophage fusion', 'positive regulation of microglial cell mediated cytotoxicity', 'positive regulation of natural killer cell activation', 'positive regulation of neuron death', 'positive regulation of osteoclast development', 'positive regulation of protein localization to cell surface', 'positive regulation of receptor localization to synapse', 'positive regulation of superoxide anion generation', 'positive regulation of tumor necrosis factor production', 'protein stabilization', 'response to axon injury', 'signal transduction', 'stimulatory C-type lectin receptor signaling pathway', 'stimulatory killer cell immunoglobulin-like receptor signaling pathway']
Stromal cell-derived factor 1
65
Stromal cell-derived factor 1
55
9.9
68
0.15
P48061P48061['adult locomotory behavior', 'animal organ regeneration', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'axon guidance', 'blood circulation', 'cell adhesion', 'cell chemotaxis', 'cellular calcium ion homeostasis', 'cellular response to chemokine', 'chemokine (C-X-C motif) ligand 12 signaling pathway', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response', 'detection of mechanical stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in sensory perception of pain', 'G protein-coupled receptor signaling pathway', 'immune response', 'induction of positive chemotaxis', 'integrin activation', 'killing of cells of another organism', 'negative regulation of dendritic cell apoptotic process', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of leukocyte tethering or rolling', 'neuron migration', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of calcium ion import', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of dopamine secretion', 'positive regulation of endothelial cell proliferation', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of T cell migration', 'regulation of actin polymerization or depolymerization', 'response to heat', 'response to hypoxia', 'response to peptide hormone', 'response to radiation', 'response to ultrasound', 'response to virus', 'signal transduction', 'T cell chemotaxis', 'telencephalon cell migration']['adult locomotory behavior', 'animal organ regeneration', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'axon guidance', 'blood circulation', 'cell adhesion', 'cell chemotaxis', 'cellular calcium ion homeostasis', 'cellular response to chemokine', 'chemokine (C-X-C motif) ligand 12 signaling pathway', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response', 'detection of mechanical stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in sensory perception of pain', 'G protein-coupled receptor signaling pathway', 'immune response', 'induction of positive chemotaxis', 'integrin activation', 'killing of cells of another organism', 'negative regulation of dendritic cell apoptotic process', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of leukocyte tethering or rolling', 'neuron migration', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of calcium ion import', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of dopamine secretion', 'positive regulation of endothelial cell proliferation', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of T cell migration', 'regulation of actin polymerization or depolymerization', 'response to heat', 'response to hypoxia', 'response to peptide hormone', 'response to radiation', 'response to ultrasound', 'response to virus', 'signal transduction', 'T cell chemotaxis', 'telencephalon cell migration']
Cytoplasmic dynein 1 intermediate chain 2
284
Cytoplasmic dynein 1 intermediate chain 2
284
9.2
65
0.17
Q13409Q13409['microtubule-based movement', 'transport along microtubule']['microtubule-based movement', 'transport along microtubule']
Uteroglobin
24
Uteroglobin
24
7.4
32
0.42
P17559P17559['negative regulation of interferon-gamma production', 'negative regulation of interleukin-13 production', 'negative regulation of interleukin-4 production', 'negative regulation of interleukin-5 production', 'negative regulation of T cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'regulation of inflammatory response', 'regulation of mRNA stability', 'response to cytokine', 'response to fibroblast growth factor', 'response to glucocorticoid', 'response to lipopolysaccharide', 'response to organic substance', 'response to ozone', 'response to silicon dioxide', 'response to xenobiotic stimulus', 'signal transduction', 'T cell proliferation']['negative regulation of interferon-gamma production', 'negative regulation of interleukin-13 production', 'negative regulation of interleukin-4 production', 'negative regulation of interleukin-5 production', 'negative regulation of T cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'regulation of inflammatory response', 'regulation of mRNA stability', 'response to cytokine', 'response to fibroblast growth factor', 'response to glucocorticoid', 'response to lipopolysaccharide', 'response to organic substance', 'response to ozone', 'response to silicon dioxide', 'response to xenobiotic stimulus', 'signal transduction', 'T cell proliferation']
Platelet factor 4
41
Platelet factor 4
43
9.9
61
0.17
P02776P02776['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'defense response to protozoan', 'inflammatory response', 'killing by host of symbiont cells', 'killing of cells of another organism', 'leukocyte chemotaxis', 'negative regulation of angiogenesis', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of megakaryocyte differentiation', 'negative regulation of MHC class II biosynthetic process', 'neutrophil chemotaxis', 'platelet activation', 'positive regulation of gene expression', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of macrophage differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'regulation of cell population proliferation']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'chemokine-mediated signaling pathway', 'cytokine-mediated signaling pathway', 'defense response to protozoan', 'inflammatory response', 'killing by host of symbiont cells', 'killing of cells of another organism', 'leukocyte chemotaxis', 'negative regulation of angiogenesis', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of megakaryocyte differentiation', 'negative regulation of MHC class II biosynthetic process', 'neutrophil chemotaxis', 'platelet activation', 'positive regulation of gene expression', 'positive regulation of macrophage derived foam cell differentiation', 'positive regulation of macrophage differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'regulation of cell population proliferation']
Stromal cell-derived factor 1
65
Stromal cell-derived factor 1
32
9.5
68
0.16
P48061P48061['adult locomotory behavior', 'animal organ regeneration', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'axon guidance', 'blood circulation', 'cell adhesion', 'cell chemotaxis', 'cellular calcium ion homeostasis', 'cellular response to chemokine', 'chemokine (C-X-C motif) ligand 12 signaling pathway', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response', 'detection of mechanical stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in sensory perception of pain', 'G protein-coupled receptor signaling pathway', 'immune response', 'induction of positive chemotaxis', 'integrin activation', 'killing of cells of another organism', 'negative regulation of dendritic cell apoptotic process', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of leukocyte tethering or rolling', 'neuron migration', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of calcium ion import', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of dopamine secretion', 'positive regulation of endothelial cell proliferation', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of T cell migration', 'regulation of actin polymerization or depolymerization', 'response to heat', 'response to hypoxia', 'response to peptide hormone', 'response to radiation', 'response to ultrasound', 'response to virus', 'signal transduction', 'T cell chemotaxis', 'telencephalon cell migration']['adult locomotory behavior', 'animal organ regeneration', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'axon guidance', 'blood circulation', 'cell adhesion', 'cell chemotaxis', 'cellular calcium ion homeostasis', 'cellular response to chemokine', 'chemokine (C-X-C motif) ligand 12 signaling pathway', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response', 'detection of mechanical stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in sensory perception of pain', 'G protein-coupled receptor signaling pathway', 'immune response', 'induction of positive chemotaxis', 'integrin activation', 'killing of cells of another organism', 'negative regulation of dendritic cell apoptotic process', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of leukocyte tethering or rolling', 'neuron migration', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of calcium ion import', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of dopamine secretion', 'positive regulation of endothelial cell proliferation', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of T cell migration', 'regulation of actin polymerization or depolymerization', 'response to heat', 'response to hypoxia', 'response to peptide hormone', 'response to radiation', 'response to ultrasound', 'response to virus', 'signal transduction', 'T cell chemotaxis', 'telencephalon cell migration']
Stromal cell-derived factor 1
65
Stromal cell-derived factor 1
71
9.5
78
0.13
P48061P48061['adult locomotory behavior', 'animal organ regeneration', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'axon guidance', 'blood circulation', 'cell adhesion', 'cell chemotaxis', 'cellular calcium ion homeostasis', 'cellular response to chemokine', 'chemokine (C-X-C motif) ligand 12 signaling pathway', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response', 'detection of mechanical stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in sensory perception of pain', 'G protein-coupled receptor signaling pathway', 'immune response', 'induction of positive chemotaxis', 'integrin activation', 'killing of cells of another organism', 'negative regulation of dendritic cell apoptotic process', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of leukocyte tethering or rolling', 'neuron migration', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of calcium ion import', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of dopamine secretion', 'positive regulation of endothelial cell proliferation', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of T cell migration', 'regulation of actin polymerization or depolymerization', 'response to heat', 'response to hypoxia', 'response to peptide hormone', 'response to radiation', 'response to ultrasound', 'response to virus', 'signal transduction', 'T cell chemotaxis', 'telencephalon cell migration']['adult locomotory behavior', 'animal organ regeneration', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'axon guidance', 'blood circulation', 'cell adhesion', 'cell chemotaxis', 'cellular calcium ion homeostasis', 'cellular response to chemokine', 'chemokine (C-X-C motif) ligand 12 signaling pathway', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response', 'detection of mechanical stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in sensory perception of pain', 'G protein-coupled receptor signaling pathway', 'immune response', 'induction of positive chemotaxis', 'integrin activation', 'killing of cells of another organism', 'negative regulation of dendritic cell apoptotic process', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of leukocyte tethering or rolling', 'neuron migration', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of calcium ion import', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of dopamine secretion', 'positive regulation of endothelial cell proliferation', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of T cell migration', 'regulation of actin polymerization or depolymerization', 'response to heat', 'response to hypoxia', 'response to peptide hormone', 'response to radiation', 'response to ultrasound', 'response to virus', 'signal transduction', 'T cell chemotaxis', 'telencephalon cell migration']
Stromal cell-derived factor 1
32
Stromal cell-derived factor 1
265
10.0
73
0.14
P48061P48061['adult locomotory behavior', 'animal organ regeneration', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'axon guidance', 'blood circulation', 'cell adhesion', 'cell chemotaxis', 'cellular calcium ion homeostasis', 'cellular response to chemokine', 'chemokine (C-X-C motif) ligand 12 signaling pathway', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response', 'detection of mechanical stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in sensory perception of pain', 'G protein-coupled receptor signaling pathway', 'immune response', 'induction of positive chemotaxis', 'integrin activation', 'killing of cells of another organism', 'negative regulation of dendritic cell apoptotic process', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of leukocyte tethering or rolling', 'neuron migration', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of calcium ion import', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of dopamine secretion', 'positive regulation of endothelial cell proliferation', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of T cell migration', 'regulation of actin polymerization or depolymerization', 'response to heat', 'response to hypoxia', 'response to peptide hormone', 'response to radiation', 'response to ultrasound', 'response to virus', 'signal transduction', 'T cell chemotaxis', 'telencephalon cell migration']['adult locomotory behavior', 'animal organ regeneration', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'axon guidance', 'blood circulation', 'cell adhesion', 'cell chemotaxis', 'cellular calcium ion homeostasis', 'cellular response to chemokine', 'chemokine (C-X-C motif) ligand 12 signaling pathway', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response', 'detection of mechanical stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in sensory perception of pain', 'G protein-coupled receptor signaling pathway', 'immune response', 'induction of positive chemotaxis', 'integrin activation', 'killing of cells of another organism', 'negative regulation of dendritic cell apoptotic process', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of leukocyte tethering or rolling', 'neuron migration', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of calcium ion import', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of dopamine secretion', 'positive regulation of endothelial cell proliferation', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of T cell migration', 'regulation of actin polymerization or depolymerization', 'response to heat', 'response to hypoxia', 'response to peptide hormone', 'response to radiation', 'response to ultrasound', 'response to virus', 'signal transduction', 'T cell chemotaxis', 'telencephalon cell migration']
Stromal cell-derived factor 1
71
Stromal cell-derived factor 1
265
9.2
76
0.14
P48061P48061['adult locomotory behavior', 'animal organ regeneration', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'axon guidance', 'blood circulation', 'cell adhesion', 'cell chemotaxis', 'cellular calcium ion homeostasis', 'cellular response to chemokine', 'chemokine (C-X-C motif) ligand 12 signaling pathway', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response', 'detection of mechanical stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in sensory perception of pain', 'G protein-coupled receptor signaling pathway', 'immune response', 'induction of positive chemotaxis', 'integrin activation', 'killing of cells of another organism', 'negative regulation of dendritic cell apoptotic process', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of leukocyte tethering or rolling', 'neuron migration', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of calcium ion import', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of dopamine secretion', 'positive regulation of endothelial cell proliferation', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of T cell migration', 'regulation of actin polymerization or depolymerization', 'response to heat', 'response to hypoxia', 'response to peptide hormone', 'response to radiation', 'response to ultrasound', 'response to virus', 'signal transduction', 'T cell chemotaxis', 'telencephalon cell migration']['adult locomotory behavior', 'animal organ regeneration', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'axon guidance', 'blood circulation', 'cell adhesion', 'cell chemotaxis', 'cellular calcium ion homeostasis', 'cellular response to chemokine', 'chemokine (C-X-C motif) ligand 12 signaling pathway', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response', 'detection of mechanical stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in sensory perception of pain', 'G protein-coupled receptor signaling pathway', 'immune response', 'induction of positive chemotaxis', 'integrin activation', 'killing of cells of another organism', 'negative regulation of dendritic cell apoptotic process', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of leukocyte tethering or rolling', 'neuron migration', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of calcium ion import', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of dopamine secretion', 'positive regulation of endothelial cell proliferation', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of T cell migration', 'regulation of actin polymerization or depolymerization', 'response to heat', 'response to hypoxia', 'response to peptide hormone', 'response to radiation', 'response to ultrasound', 'response to virus', 'signal transduction', 'T cell chemotaxis', 'telencephalon cell migration']
Insulin
96
Insulin
31
2.0
nan
nan
Q5EEX2Q5EEX2['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']
Insulin
100
Insulin
31
9.8
nan
nan
Q5EEX2Q5EEX2['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']
Defensin alpha 5
92
Defensin alpha 5
65
9.2
70
0.16
Q01523Q01523['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']
Insulin
95
Insulin
31
9.1
nan
nan
Q5EEX2Q5EEX2['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']
Defensin alpha 5
72
Defensin alpha 5
65
9.9
55
0.18
Q01523Q01523['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'innate immune response in mucosa', 'killing by host of symbiont cells', 'killing of cells of another organism', 'membrane disruption in another organism', 'positive regulation of interleukin-8 production', 'positive regulation of membrane permeability', 'protein homotetramerization']
Protegrin-3
136
Protegrin-3
136
7.7
39
0.33
P32196P32196['antimicrobial humoral immune response mediated by antimicrobial peptide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response']
T-cell surface glycoprotein CD8 alpha chain
215
Tyrosine-protein kinase Lck
23
3.9
40
0.65
P01732P06239['adaptive immune response', 'antigen processing and presentation', 'cell surface receptor signaling pathway', 'cytotoxic T cell differentiation', 'immune response', 'T cell activation', 'T cell mediated immunity', 'T cell receptor signaling pathway', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'B cell receptor signaling pathway', 'cell differentiation', 'cellular zinc ion homeostasis', 'Fc-gamma receptor signaling pathway', 'hemopoiesis', 'innate immune response', 'intracellular signal transduction', 'leukocyte migration', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'platelet activation', 'positive regulation of heterotypic cell-cell adhesion', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of leukocyte cell-cell adhesion', 'positive regulation of T cell activation', 'positive regulation of T cell receptor signaling pathway', 'protein phosphorylation', 'regulation of lymphocyte activation', 'release of sequestered calcium ion into cytosol', 'response to xenobiotic stimulus', 'T cell costimulation', 'T cell differentiation', 'T cell receptor signaling pathway', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Protegrin-3
145
Protegrin-3
145
6.5
50
0.31
P32196P32196['antimicrobial humoral immune response mediated by antimicrobial peptide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response']['antimicrobial humoral immune response mediated by antimicrobial peptide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response']
Trefoil factor 3
78
Trefoil factor 3
78
2.1
82
0.57
Q07654Q07654['maintenance of gastrointestinal epithelium', 'regulation of glucose metabolic process']['maintenance of gastrointestinal epithelium', 'regulation of glucose metabolic process']
Relaxin-3
35
Insulin-like peptide INSL5
122
2.0
43
1.14
Q8WXF3Q9Y5Q6[]['positive regulation of feeding behavior']
Insulin-like 3
116
Insulin-like 3
34
2.0
49
1.0
P51460P51460['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'cell-cell signaling', 'male gonad development', 'negative regulation of apoptotic process', 'negative regulation of cell population proliferation', 'oocyte maturation', 'positive regulation of cAMP-mediated signaling', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of wound healing', 'spermatogenesis']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'cell-cell signaling', 'male gonad development', 'negative regulation of apoptotic process', 'negative regulation of cell population proliferation', 'oocyte maturation', 'positive regulation of cAMP-mediated signaling', 'positive regulation of cell population proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of wound healing', 'spermatogenesis']
Trefoil factor 1
82
Trefoil factor 1
82
2.0
27
1.82
P04155P04155['carbohydrate metabolic process', 'cell differentiation', 'cell population proliferation', 'maintenance of gastrointestinal epithelium', 'negative regulation of cell population proliferation', 'response to immobilization stress', 'response to iron ion', 'response to peptide hormone']['carbohydrate metabolic process', 'cell differentiation', 'cell population proliferation', 'maintenance of gastrointestinal epithelium', 'negative regulation of cell population proliferation', 'response to immobilization stress', 'response to iron ion', 'response to peptide hormone']
Cardiac phospholamban
41
Cardiac phospholamban
46
9.3
58
0.19
P26678P26678['adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'blood circulation', 'cardiac muscle tissue development', 'muscle cell cellular homeostasis', 'negative regulation of ATP-dependent activity', 'negative regulation of ATPase-coupled calcium transmembrane transporter activity', 'negative regulation of calcium ion binding', 'negative regulation of calcium ion import', 'negative regulation of calcium ion import into sarcoplasmic reticulum', 'negative regulation of calcium ion transmembrane transporter activity', 'negative regulation of calcium ion transport', 'negative regulation of catalytic activity', 'negative regulation of heart rate', 'Notch signaling pathway', 'regulation of ATPase-coupled calcium transmembrane transporter activity', 'regulation of calcium ion transport', 'regulation of cardiac muscle cell contraction', 'regulation of cardiac muscle cell membrane potential', 'regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion', 'regulation of cytosolic calcium ion concentration', 'regulation of heart contraction', 'regulation of relaxation of cardiac muscle', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of the force of heart contraction', 'regulation of the force of heart contraction by cardiac conduction', 'relaxation of cardiac muscle']['adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'blood circulation', 'cardiac muscle tissue development', 'muscle cell cellular homeostasis', 'negative regulation of ATP-dependent activity', 'negative regulation of ATPase-coupled calcium transmembrane transporter activity', 'negative regulation of calcium ion binding', 'negative regulation of calcium ion import', 'negative regulation of calcium ion import into sarcoplasmic reticulum', 'negative regulation of calcium ion transmembrane transporter activity', 'negative regulation of calcium ion transport', 'negative regulation of catalytic activity', 'negative regulation of heart rate', 'Notch signaling pathway', 'regulation of ATPase-coupled calcium transmembrane transporter activity', 'regulation of calcium ion transport', 'regulation of cardiac muscle cell contraction', 'regulation of cardiac muscle cell membrane potential', 'regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion', 'regulation of cytosolic calcium ion concentration', 'regulation of heart contraction', 'regulation of relaxation of cardiac muscle', 'regulation of ryanodine-sensitive calcium-release channel activity', 'regulation of the force of heart contraction', 'regulation of the force of heart contraction by cardiac conduction', 'relaxation of cardiac muscle']
Insulin
109
Insulin
43
2.0
50
0.98
Q5EEX2Q5EEX2['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']
Defensin alpha-like protein 1
71
Defensin alpha-like protein 1
71
2.0
28
1.76
Q4JEI2Q4JEI2['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']['antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to lipopolysaccharide', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response in mucosa', 'membrane disruption in another organism']
Oxytocin-neurophysin 1
65
Oxytocin-neurophysin 1
65
9.7
102
0.1
P01175P01175['positive regulation of cold-induced thermogenesis', 'response to estrogen', 'response to external biotic stimulus', 'response to food', 'response to mechanical stimulus']['positive regulation of cold-induced thermogenesis', 'response to estrogen', 'response to external biotic stimulus', 'response to food', 'response to mechanical stimulus']
Protein S100-A11
10
Protein S100-A11
10
9.2
72
0.15
P24480P24480['regulation of cell population proliferation']['regulation of cell population proliferation']
Relaxin-3
47
Insulin-like peptide INSL5
135
2.0
nan
nan
Q8WXF3Q9Y5Q6[]['positive regulation of feeding behavior']
Relaxin-3
35
Relaxin-3
129
2.0
50
0.99
Q8WXF3Q8WXF3[][]
C-C motif chemokine 2
35
C-C motif chemokine 2
34
9.5
76
0.14
P13500P13500['angiogenesis', 'animal organ morphogenesis', 'astrocyte cell migration', 'cell adhesion', 'cell surface receptor signaling pathway', 'cellular homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to lipopolysaccharide', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'cytoskeleton organization', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'helper T cell extravasation', 'humoral immune response', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of glial cell apoptotic process', 'negative regulation of natural killer cell chemotaxis', 'negative regulation of neuron apoptotic process', 'negative regulation of vascular endothelial cell proliferation', 'neutrophil chemotaxis', 'positive regulation of apoptotic cell clearance', 'positive regulation of calcium ion import', 'positive regulation of endothelial cell apoptotic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of nitric-oxide synthase biosynthetic process', 'positive regulation of NMDA glutamate receptor activity', 'positive regulation of synaptic transmission, glutamatergic', 'positive regulation of T cell activation', 'protein kinase B signaling', 'protein phosphorylation', 'receptor signaling pathway via JAK-STAT', 'regulation of cell shape', 'response to bacterium', 'sensory perception of pain', 'signal transduction', 'viral genome replication']['angiogenesis', 'animal organ morphogenesis', 'astrocyte cell migration', 'cell adhesion', 'cell surface receptor signaling pathway', 'cellular homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to lipopolysaccharide', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'cytoskeleton organization', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'helper T cell extravasation', 'humoral immune response', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of glial cell apoptotic process', 'negative regulation of natural killer cell chemotaxis', 'negative regulation of neuron apoptotic process', 'negative regulation of vascular endothelial cell proliferation', 'neutrophil chemotaxis', 'positive regulation of apoptotic cell clearance', 'positive regulation of calcium ion import', 'positive regulation of endothelial cell apoptotic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of nitric-oxide synthase biosynthetic process', 'positive regulation of NMDA glutamate receptor activity', 'positive regulation of synaptic transmission, glutamatergic', 'positive regulation of T cell activation', 'protein kinase B signaling', 'protein phosphorylation', 'receptor signaling pathway via JAK-STAT', 'regulation of cell shape', 'response to bacterium', 'sensory perception of pain', 'signal transduction', 'viral genome replication']
Insulin-like growth factor 2 receptor variant
1521
Insulin-like growth factor II
75
9.3
64
0.17
Q59EZ3P01344['lysosomal transport']['animal organ morphogenesis', 'embryonic placenta development', 'embryonic placenta morphogenesis', 'exocrine pancreas development', 'glucose metabolic process', 'in utero embryonic development', 'insulin receptor signaling pathway', 'insulin receptor signaling pathway via phosphatidylinositol 3-kinase', 'negative regulation of muscle cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'osteoblast differentiation', 'positive regulation of activated T cell proliferation', 'positive regulation of catalytic activity', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of glycogen (starch) synthase activity', 'positive regulation of glycogen biosynthetic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of multicellular organism growth', 'positive regulation of organ growth', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of skeletal muscle tissue growth', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vascular endothelial cell proliferation', 'regulation of gene expression by genomic imprinting', 'regulation of histone modification', 'regulation of muscle cell differentiation', 'regulation of transcription, DNA-templated', 'spongiotrophoblast cell proliferation', 'striated muscle cell differentiation']
Tumor necrosis factor receptor superfamily member 16
381
Tumor necrosis factor receptor superfamily member 16
381
6.9
74
0.2
P08138P08138['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'axon guidance', 'cellular glucose homeostasis', 'cellular response to amyloid-beta', 'central nervous system development', 'circadian regulation of gene expression', 'detection of temperature stimulus', 'dorsal aorta development', 'fibroblast growth factor receptor signaling pathway', 'fibroblast proliferation', 'glucose homeostasis', 'hair follicle morphogenesis', 'intracellular protein transport', 'negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'negative regulation of cell migration', 'negative regulation of fibroblast growth factor receptor signaling pathway', 'negative regulation of hair follicle development', 'nerve development', 'neuron apoptotic process', 'odontogenesis of dentin-containing tooth', 'positive regulation of apoptotic signaling pathway', 'positive regulation of fibroblast proliferation', 'positive regulation of miRNA transcription', 'positive regulation of odontogenesis of dentin-containing tooth', 'positive regulation of protein localization to nucleus', 'Rho protein signal transduction']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'axon guidance', 'cellular glucose homeostasis', 'cellular response to amyloid-beta', 'central nervous system development', 'circadian regulation of gene expression', 'detection of temperature stimulus', 'dorsal aorta development', 'fibroblast growth factor receptor signaling pathway', 'fibroblast proliferation', 'glucose homeostasis', 'hair follicle morphogenesis', 'intracellular protein transport', 'negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis', 'negative regulation of cell migration', 'negative regulation of fibroblast growth factor receptor signaling pathway', 'negative regulation of hair follicle development', 'nerve development', 'neuron apoptotic process', 'odontogenesis of dentin-containing tooth', 'positive regulation of apoptotic signaling pathway', 'positive regulation of fibroblast proliferation', 'positive regulation of miRNA transcription', 'positive regulation of odontogenesis of dentin-containing tooth', 'positive regulation of protein localization to nucleus', 'Rho protein signal transduction']
Microtubule-associated protein RP/EB family member 1
228
Microtubule-associated protein RP/EB family member 1
228
9.8
68
0.15
Q61166Q61166['attachment of mitotic spindle microtubules to kinetochore', 'cell division', 'cell migration', 'establishment of mitotic spindle orientation', 'microtubule bundle formation', 'microtubule polymerization', 'negative regulation of microtubule polymerization', 'non-motile cilium assembly', 'positive regulation of microtubule plus-end binding', 'positive regulation of microtubule polymerization', 'protein localization to astral microtubule', 'protein localization to centrosome', 'protein localization to microtubule', 'protein localization to microtubule plus-end', 'regulation of microtubule polymerization or depolymerization', 'spindle assembly']['attachment of mitotic spindle microtubules to kinetochore', 'cell division', 'cell migration', 'establishment of mitotic spindle orientation', 'microtubule bundle formation', 'microtubule polymerization', 'negative regulation of microtubule polymerization', 'non-motile cilium assembly', 'positive regulation of microtubule plus-end binding', 'positive regulation of microtubule polymerization', 'protein localization to astral microtubule', 'protein localization to centrosome', 'protein localization to microtubule', 'protein localization to microtubule plus-end', 'regulation of microtubule polymerization or depolymerization', 'spindle assembly']
Superoxide dismutase [Cu-Zn]
147
Superoxide dismutase [Cu-Zn]
147
9.8
97
0.11
P00441P00441['aging', 'anterograde axonal transport', 'apoptotic process', 'auditory receptor cell stereocilium organization', 'cellular iron ion homeostasis', 'cellular response to ATP', 'cellular response to cadmium ion', 'cellular response to potassium ion', 'ectopic germ cell programmed cell death', 'embryo implantation', 'glutathione metabolic process', 'heart contraction', 'hydrogen peroxide biosynthetic process', 'locomotory behavior', 'muscle cell cellular homeostasis', 'myeloid cell homeostasis', 'negative regulation of cholesterol biosynthetic process', 'negative regulation of developmental process', 'negative regulation of inflammatory response', 'negative regulation of neuron apoptotic process', 'negative regulation of reproductive process', 'neurofilament cytoskeleton organization', 'ovarian follicle development', 'peripheral nervous system myelin maintenance', 'placenta development', 'positive regulation of apoptotic process', 'positive regulation of catalytic activity', 'positive regulation of cytokine production', 'positive regulation of MAPK cascade', 'positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'positive regulation of phagocytosis', 'positive regulation of superoxide anion generation', 'reactive oxygen species metabolic process', 'regulation of blood pressure', 'regulation of GTPase activity', 'regulation of mitochondrial membrane potential', 'regulation of multicellular organism growth', 'regulation of organ growth', 'regulation of protein kinase activity', 'regulation of T cell differentiation in thymus', 'relaxation of vascular associated smooth muscle', 'removal of superoxide radicals', 'response to amphetamine', 'response to antibiotic', 'response to antipsychotic drug', 'response to axon injury', 'response to carbon monoxide', 'response to copper ion', 'response to ethanol', 'response to heat', 'response to hydrogen peroxide', 'response to nutrient levels', 'response to organic substance', 'response to superoxide', 'response to xenobiotic stimulus', 'retina homeostasis', 'retrograde axonal transport', 'sensory perception of sound', 'spermatogenesis', 'superoxide anion generation', 'superoxide metabolic process', 'thymus development', 'transmission of nerve impulse']['aging', 'anterograde axonal transport', 'apoptotic process', 'auditory receptor cell stereocilium organization', 'cellular iron ion homeostasis', 'cellular response to ATP', 'cellular response to cadmium ion', 'cellular response to potassium ion', 'ectopic germ cell programmed cell death', 'embryo implantation', 'glutathione metabolic process', 'heart contraction', 'hydrogen peroxide biosynthetic process', 'locomotory behavior', 'muscle cell cellular homeostasis', 'myeloid cell homeostasis', 'negative regulation of cholesterol biosynthetic process', 'negative regulation of developmental process', 'negative regulation of inflammatory response', 'negative regulation of neuron apoptotic process', 'negative regulation of reproductive process', 'neurofilament cytoskeleton organization', 'ovarian follicle development', 'peripheral nervous system myelin maintenance', 'placenta development', 'positive regulation of apoptotic process', 'positive regulation of catalytic activity', 'positive regulation of cytokine production', 'positive regulation of MAPK cascade', 'positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'positive regulation of phagocytosis', 'positive regulation of superoxide anion generation', 'reactive oxygen species metabolic process', 'regulation of blood pressure', 'regulation of GTPase activity', 'regulation of mitochondrial membrane potential', 'regulation of multicellular organism growth', 'regulation of organ growth', 'regulation of protein kinase activity', 'regulation of T cell differentiation in thymus', 'relaxation of vascular associated smooth muscle', 'removal of superoxide radicals', 'response to amphetamine', 'response to antibiotic', 'response to antipsychotic drug', 'response to axon injury', 'response to carbon monoxide', 'response to copper ion', 'response to ethanol', 'response to heat', 'response to hydrogen peroxide', 'response to nutrient levels', 'response to organic substance', 'response to superoxide', 'response to xenobiotic stimulus', 'retina homeostasis', 'retrograde axonal transport', 'sensory perception of sound', 'spermatogenesis', 'superoxide anion generation', 'superoxide metabolic process', 'thymus development', 'transmission of nerve impulse']
Oxytocin-neurophysin 1
105
Oxytocin-neurophysin 1
105
9.8
92
0.11
P01175P01175['positive regulation of cold-induced thermogenesis', 'response to estrogen', 'response to external biotic stimulus', 'response to food', 'response to mechanical stimulus']['positive regulation of cold-induced thermogenesis', 'response to estrogen', 'response to external biotic stimulus', 'response to food', 'response to mechanical stimulus']
Insulin
95
Insulin
43
9.5
51
0.21
P01317P01317['estradiol secretion', 'feeding behavior', 'glucose import in response to insulin stimulus', 'glucose metabolic process', 'negative regulation of apoptotic process', 'negative regulation of appetite', 'negative regulation of lactation', 'negative regulation of lipid catabolic process', 'positive regulation of blood circulation', 'positive regulation of cell maturation', 'positive regulation of gene expression', 'positive regulation of insulin secretion', 'positive regulation of lactation', 'positive regulation of mammary gland epithelial cell proliferation', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Rho protein signal transduction', 'protein secretion', 'response to butyrate', 'response to food', 'response to glucose', 'response to growth hormone', 'response to heat', 'response to L-arginine', 'response to nutrient levels']['estradiol secretion', 'feeding behavior', 'glucose import in response to insulin stimulus', 'glucose metabolic process', 'negative regulation of apoptotic process', 'negative regulation of appetite', 'negative regulation of lactation', 'negative regulation of lipid catabolic process', 'positive regulation of blood circulation', 'positive regulation of cell maturation', 'positive regulation of gene expression', 'positive regulation of insulin secretion', 'positive regulation of lactation', 'positive regulation of mammary gland epithelial cell proliferation', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Rho protein signal transduction', 'protein secretion', 'response to butyrate', 'response to food', 'response to glucose', 'response to growth hormone', 'response to heat', 'response to L-arginine', 'response to nutrient levels']
Beta-nerve growth factor
136
Beta-nerve growth factor
189
9.6
77
0.14
P01139P01139['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'adult locomotory behavior', 'axon extension', 'circadian rhythm', 'extrinsic apoptotic signaling pathway in absence of ligand', 'extrinsic apoptotic signaling pathway via death domain receptors', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of type B pancreatic cell apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron projection development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of axon extension', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of collateral sprouting', 'positive regulation of DNA binding', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of neuron differentiation', 'positive regulation of neuron maturation', 'positive regulation of neuron projection development', 'positive regulation of neurotrophin TRK receptor signaling pathway', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein autophosphorylation', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of protein ubiquitination', 'positive regulation of Ras protein signal transduction', 'positive regulation of stem cell proliferation', 'protein phosphorylation', 'regulation of neuron differentiation', 'regulation of neurotransmitter secretion', 'regulation of release of sequestered calcium ion into cytosol', 'sensory perception of pain', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'adult locomotory behavior', 'axon extension', 'circadian rhythm', 'extrinsic apoptotic signaling pathway in absence of ligand', 'extrinsic apoptotic signaling pathway via death domain receptors', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of type B pancreatic cell apoptotic process', 'nerve development', 'nerve growth factor signaling pathway', 'neuron apoptotic process', 'neuron projection development', 'neuron projection morphogenesis', 'peripheral nervous system development', 'positive regulation of axon extension', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of collateral sprouting', 'positive regulation of DNA binding', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of neuron differentiation', 'positive regulation of neuron maturation', 'positive regulation of neuron projection development', 'positive regulation of neurotrophin TRK receptor signaling pathway', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein autophosphorylation', 'positive regulation of protein binding', 'positive regulation of protein phosphorylation', 'positive regulation of protein ubiquitination', 'positive regulation of Ras protein signal transduction', 'positive regulation of stem cell proliferation', 'protein phosphorylation', 'regulation of neuron differentiation', 'regulation of neurotransmitter secretion', 'regulation of release of sequestered calcium ion into cytosol', 'sensory perception of pain', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Suppressor of cytokine signaling 3
193
Elongin-C
112
9.4
nan
nan
O35718P83940['branching involved in labyrinthine layer morphogenesis', 'cell differentiation', 'cellular response to interleukin-17', 'cellular response to leukemia inhibitory factor', 'intracellular signal transduction', 'negative regulation of apoptotic process', 'negative regulation of inflammatory response', 'negative regulation of insulin receptor signaling pathway', 'negative regulation of receptor signaling pathway via JAK-STAT', 'negative regulation of signal transduction', 'negative regulation of tyrosine phosphorylation of STAT protein', 'phosphatidylinositol phosphate biosynthetic process', 'placenta blood vessel development', 'positive regulation of cell differentiation', 'protein ubiquitination', 'receptor signaling pathway via JAK-STAT', 'regulation of growth', 'regulation of protein phosphorylation', 'signal transduction']['positive regulation of transcription elongation from RNA polymerase II promoter', 'protein ubiquitination', 'transcription initiation from RNA polymerase II promoter', 'ubiquitin-dependent protein catabolic process']
Hypoxia-inducible factor 1-alpha
800
Histone acetyltransferase p300
414
9.9
74
0.14
Q16665Q09472['angiogenesis', 'axonal transport of mitochondrion', 'B-1 B cell homeostasis', 'bone mineralization', 'cardiac ventricle morphogenesis', 'cellular glucose homeostasis', 'cellular iron ion homeostasis', 'cellular response to hypoxia', 'cellular response to interleukin-1', 'cellular response to virus', 'cerebral cortex development', 'chondrocyte differentiation', 'collagen metabolic process', 'connective tissue replacement involved in inflammatory response wound healing', 'digestive tract morphogenesis', 'dopaminergic neuron differentiation', 'elastin metabolic process', 'embryonic hemopoiesis', 'embryonic placenta development', 'epithelial cell differentiation involved in mammary gland alveolus development', 'epithelial to mesenchymal transition', 'glandular epithelial cell maturation', 'heart looping', 'hemoglobin biosynthetic process', 'hypoxia-inducible factor-1alpha signaling pathway', 'insulin secretion involved in cellular response to glucose stimulus', 'intestinal epithelial cell maturation', 'iris morphogenesis', 'lactate metabolic process', 'lactation', 'mesenchymal cell apoptotic process', 'muscle cell cellular homeostasis', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'negative regulation of growth', 'negative regulation of mesenchymal cell apoptotic process', 'negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway', 'negative regulation of reactive oxygen species metabolic process', 'negative regulation of thymocyte apoptotic process', 'negative regulation of TOR signaling', 'neural crest cell migration', 'neural fold elevation formation', 'neuroblast proliferation', 'neuron apoptotic process', 'outflow tract morphogenesis', 'oxygen homeostasis', 'positive regulation of angiogenesis', 'positive regulation of autophagy of mitochondrion', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of chemokine production', 'positive regulation of chemokine-mediated signaling pathway', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of endothelial cell proliferation', 'positive regulation of epithelial cell migration', 'positive regulation of erythrocyte differentiation', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of hormone biosynthetic process', 'positive regulation of insulin secretion involved in cellular response to glucose stimulus', 'positive regulation of macroautophagy', 'positive regulation of miRNA transcription', 'positive regulation of neuroblast proliferation', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of signaling receptor activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular endothelial growth factor receptor signaling pathway', 'regulation of aerobic respiration', 'regulation of gene expression', 'regulation of glycolytic process', 'regulation of protein neddylation', 'regulation of transcription by RNA polymerase II', 'regulation of transcription from RNA polymerase II promoter in response to oxidative stress', 'regulation of transcription, DNA-templated', 'regulation of transforming growth factor beta2 production', 'response to hypoxia', 'response to iron ion', 'response to muscle activity', 'response to reactive oxygen species', 'retina vasculature development in camera-type eye', 'signal transduction', 'TOR signaling', 'vascular endothelial growth factor production', 'visual learning']['animal organ morphogenesis', 'apoptotic process', 'B cell differentiation', 'behavioral defense response', 'cell cycle', 'cellular response to UV', 'circadian rhythm', 'epigenetic maintenance of chromatin in transcription-competent conformation', 'face morphogenesis', 'fat cell differentiation', 'heart development', 'histone acetylation', 'histone H2B acetylation', 'histone H3-K56 acetylation', 'histone H4 acetylation', 'internal peptidyl-lysine acetylation', 'internal protein amino acid acetylation', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'learning or memory', 'lung development', 'macrophage derived foam cell differentiation', 'megakaryocyte development', 'multicellular organism growth', 'N-terminal peptidyl-lysine acetylation', 'negative regulation of gluconeogenesis', 'negative regulation of protein-containing complex assembly', 'negative regulation of transcription by RNA polymerase II', 'nervous system development', 'peptidyl-lysine acetylation', 'peptidyl-lysine butyrylation', 'peptidyl-lysine crotonylation', 'peptidyl-lysine propionylation', 'platelet formation', 'positive regulation by host of viral transcription', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of neuron projection development', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of NIK/NF-kappaB signaling', 'positive regulation of protein binding', 'positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response', 'positive regulation of transcription, DNA-templated', 'positive regulation of transforming growth factor beta receptor signaling pathway', 'protein acetylation', 'protein destabilization', 'protein stabilization', 'regulation of androgen receptor signaling pathway', 'regulation of autophagy', 'regulation of cellular response to heat', 'regulation of glycolytic process', 'regulation of mitochondrion organization', 'regulation of signal transduction by p53 class mediator', 'regulation of tubulin deacetylation', 'response to estrogen', 'response to hypoxia', 'skeletal muscle tissue development', 'somitogenesis', 'stimulatory C-type lectin receptor signaling pathway', 'swimming', 'thigmotaxis', 'transcription by RNA polymerase II']
Trefoil factor 3
42
Trefoil factor 3
42
9.2
69
0.16
Q07654Q07654['maintenance of gastrointestinal epithelium', 'regulation of glucose metabolic process']['maintenance of gastrointestinal epithelium', 'regulation of glucose metabolic process']
Protein S100-A14
62
Protein S100-A14
4
8.6
20
0.58
Q9HCY8Q9HCY8['apoptotic process', 'calcium ion homeostasis', 'defense response to bacterium', 'positive regulation of granulocyte chemotaxis', 'positive regulation of monocyte chemotaxis', 'response to lipopolysaccharide', 'toll-like receptor 4 signaling pathway']['apoptotic process', 'calcium ion homeostasis', 'defense response to bacterium', 'positive regulation of granulocyte chemotaxis', 'positive regulation of monocyte chemotaxis', 'response to lipopolysaccharide', 'toll-like receptor 4 signaling pathway']
Receptor-interacting serine/threonine-protein kinase 3
445
Receptor-interacting serine/threonine-protein kinase 3
445
9.9
55
0.18
Q9QZL0Q9QZL0['activation of protein kinase activity', 'amyloid fibril formation', 'apoptotic process', 'cellular response to hydrogen peroxide', 'defense response to virus', 'execution phase of necroptosis', 'I-kappaB kinase/NF-kappaB signaling', 'lymph node development', 'necroptotic process', 'necroptotic signaling pathway', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of ligase activity', 'positive regulation of necroptotic process', 'positive regulation of necrotic cell death', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of oxidoreductase activity', 'positive regulation of phosphatase activity', 'positive regulation of reactive oxygen species metabolic process', 'programmed necrotic cell death', 'protein autophosphorylation', 'reactive oxygen species metabolic process', 'regulation of activated T cell proliferation', 'regulation of activation-induced cell death of T cells', 'regulation of adaptive immune response', 'regulation of apoptotic process', 'regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation', 'regulation of interferon-gamma production', 'regulation of reactive oxygen species metabolic process', 'regulation of T cell mediated cytotoxicity', 'signal transduction', 'spleen development', 'T cell differentiation in thymus', 'T cell homeostasis', 'thymus development']['activation of protein kinase activity', 'amyloid fibril formation', 'apoptotic process', 'cellular response to hydrogen peroxide', 'defense response to virus', 'execution phase of necroptosis', 'I-kappaB kinase/NF-kappaB signaling', 'lymph node development', 'necroptotic process', 'necroptotic signaling pathway', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of ligase activity', 'positive regulation of necroptotic process', 'positive regulation of necrotic cell death', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of oxidoreductase activity', 'positive regulation of phosphatase activity', 'positive regulation of reactive oxygen species metabolic process', 'programmed necrotic cell death', 'protein autophosphorylation', 'reactive oxygen species metabolic process', 'regulation of activated T cell proliferation', 'regulation of activation-induced cell death of T cells', 'regulation of adaptive immune response', 'regulation of apoptotic process', 'regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation', 'regulation of interferon-gamma production', 'regulation of reactive oxygen species metabolic process', 'regulation of T cell mediated cytotoxicity', 'signal transduction', 'spleen development', 'T cell differentiation in thymus', 'T cell homeostasis', 'thymus development']
Receptor-interacting serine/threonine-protein kinase 3
455
Receptor-interacting serine/threonine-protein kinase 3
455
5.2
80
0.24
Q9Y572Q9Y572['activation of protein kinase activity', 'amyloid fibril formation', 'apoptotic signaling pathway', 'cellular response to hydrogen peroxide', 'defense response to virus', 'execution phase of necroptosis', 'I-kappaB kinase/NF-kappaB signaling', 'lymph node development', 'necroptotic process', 'necroptotic signaling pathway', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of ligase activity', 'positive regulation of necroptotic process', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of oxidoreductase activity', 'positive regulation of phosphatase activity', 'positive regulation of reactive oxygen species metabolic process', 'programmed necrotic cell death', 'protein autophosphorylation', 'protein modification process', 'reactive oxygen species metabolic process', 'regulation of activated T cell proliferation', 'regulation of activation-induced cell death of T cells', 'regulation of adaptive immune response', 'regulation of apoptotic process', 'regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation', 'regulation of interferon-gamma production', 'regulation of T cell mediated cytotoxicity', 'signal transduction', 'spleen development', 'T cell differentiation in thymus', 'T cell homeostasis', 'thymus development']['activation of protein kinase activity', 'amyloid fibril formation', 'apoptotic signaling pathway', 'cellular response to hydrogen peroxide', 'defense response to virus', 'execution phase of necroptosis', 'I-kappaB kinase/NF-kappaB signaling', 'lymph node development', 'necroptotic process', 'necroptotic signaling pathway', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of ligase activity', 'positive regulation of necroptotic process', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of oxidoreductase activity', 'positive regulation of phosphatase activity', 'positive regulation of reactive oxygen species metabolic process', 'programmed necrotic cell death', 'protein autophosphorylation', 'protein modification process', 'reactive oxygen species metabolic process', 'regulation of activated T cell proliferation', 'regulation of activation-induced cell death of T cells', 'regulation of adaptive immune response', 'regulation of apoptotic process', 'regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation', 'regulation of interferon-gamma production', 'regulation of T cell mediated cytotoxicity', 'signal transduction', 'spleen development', 'T cell differentiation in thymus', 'T cell homeostasis', 'thymus development']
Beta-2-microglobulin
45
Beta-2-microglobulin
45
5.6
49
0.37
P61769P61769['amyloid fibril formation', 'antibacterial humoral response', 'antigen processing and presentation of endogenous peptide antigen via MHC class I', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to iron ion', 'cellular response to iron(III) ion', 'cellular response to lipopolysaccharide', 'cellular response to nicotine', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'iron ion homeostasis', 'iron ion transport', 'learning or memory', 'negative regulation of epithelial cell proliferation', 'negative regulation of forebrain neuron differentiation', 'negative regulation of neurogenesis', 'negative regulation of neuron projection development', 'negative regulation of receptor binding', 'peptide antigen assembly with MHC class II protein complex', 'positive regulation of cellular senescence', 'positive regulation of ferrous iron binding', 'positive regulation of protein binding', 'positive regulation of receptor binding', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of T cell activation', 'positive regulation of T cell cytokine production', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of transferrin receptor binding', 'protein homotetramerization', 'protein refolding', 'regulation of erythrocyte differentiation', 'regulation of iron ion transport', 'regulation of membrane depolarization', 'response to molecule of bacterial origin', 'retina homeostasis', 'sensory perception of smell', 'T cell differentiation in thymus', 'T cell mediated cytotoxicity']['amyloid fibril formation', 'antibacterial humoral response', 'antigen processing and presentation of endogenous peptide antigen via MHC class I', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to iron ion', 'cellular response to iron(III) ion', 'cellular response to lipopolysaccharide', 'cellular response to nicotine', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'iron ion homeostasis', 'iron ion transport', 'learning or memory', 'negative regulation of epithelial cell proliferation', 'negative regulation of forebrain neuron differentiation', 'negative regulation of neurogenesis', 'negative regulation of neuron projection development', 'negative regulation of receptor binding', 'peptide antigen assembly with MHC class II protein complex', 'positive regulation of cellular senescence', 'positive regulation of ferrous iron binding', 'positive regulation of protein binding', 'positive regulation of receptor binding', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of T cell activation', 'positive regulation of T cell cytokine production', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of transferrin receptor binding', 'protein homotetramerization', 'protein refolding', 'regulation of erythrocyte differentiation', 'regulation of iron ion transport', 'regulation of membrane depolarization', 'response to molecule of bacterial origin', 'retina homeostasis', 'sensory perception of smell', 'T cell differentiation in thymus', 'T cell mediated cytotoxicity']
Mitochondrial antiviral-signaling protein
13
Mitochondrial antiviral-signaling protein
33
9.8
63
0.16
Q7Z434Q7Z434['activation of innate immune response', 'cellular response to exogenous dsRNA', 'defense response to bacterium', 'defense response to virus', 'innate immune response', 'negative regulation of viral genome replication', 'positive regulation of chemokine (C-C motif) ligand 5 production', 'positive regulation of defense response to virus by host', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interferon-alpha production', 'positive regulation of interferon-beta production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of IP-10 production', 'positive regulation of myeloid dendritic cell cytokine production', 'positive regulation of protein import into nucleus', 'positive regulation of protein phosphorylation', 'positive regulation of response to cytokine stimulus', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'positive regulation of type I interferon-mediated signaling pathway', 'regulation of peroxisome organization', 'signal transduction', 'type I interferon signaling pathway']['activation of innate immune response', 'cellular response to exogenous dsRNA', 'defense response to bacterium', 'defense response to virus', 'innate immune response', 'negative regulation of viral genome replication', 'positive regulation of chemokine (C-C motif) ligand 5 production', 'positive regulation of defense response to virus by host', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interferon-alpha production', 'positive regulation of interferon-beta production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of IP-10 production', 'positive regulation of myeloid dendritic cell cytokine production', 'positive regulation of protein import into nucleus', 'positive regulation of protein phosphorylation', 'positive regulation of response to cytokine stimulus', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'positive regulation of type I interferon-mediated signaling pathway', 'regulation of peroxisome organization', 'signal transduction', 'type I interferon signaling pathway']
Mitochondrial antiviral-signaling protein
46
Mitochondrial antiviral-signaling protein
46
9.8
74
0.14
Q7Z434Q7Z434['activation of innate immune response', 'cellular response to exogenous dsRNA', 'defense response to bacterium', 'defense response to virus', 'innate immune response', 'negative regulation of viral genome replication', 'positive regulation of chemokine (C-C motif) ligand 5 production', 'positive regulation of defense response to virus by host', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interferon-alpha production', 'positive regulation of interferon-beta production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of IP-10 production', 'positive regulation of myeloid dendritic cell cytokine production', 'positive regulation of protein import into nucleus', 'positive regulation of protein phosphorylation', 'positive regulation of response to cytokine stimulus', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'positive regulation of type I interferon-mediated signaling pathway', 'regulation of peroxisome organization', 'signal transduction', 'type I interferon signaling pathway']['activation of innate immune response', 'cellular response to exogenous dsRNA', 'defense response to bacterium', 'defense response to virus', 'innate immune response', 'negative regulation of viral genome replication', 'positive regulation of chemokine (C-C motif) ligand 5 production', 'positive regulation of defense response to virus by host', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interferon-alpha production', 'positive regulation of interferon-beta production', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of IP-10 production', 'positive regulation of myeloid dendritic cell cytokine production', 'positive regulation of protein import into nucleus', 'positive regulation of protein phosphorylation', 'positive regulation of response to cytokine stimulus', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production', 'positive regulation of type I interferon-mediated signaling pathway', 'regulation of peroxisome organization', 'signal transduction', 'type I interferon signaling pathway']
Protein cornichon homolog 3
9
Glutamate receptor 2
549
7.8
80
0.16
Q6ZWS4P19491['localization within membrane', 'neurotransmitter receptor localization to postsynaptic specialization membrane', 'regulation of AMPA receptor activity', 'regulation of membrane potential', 'synaptic transmission, glutamatergic', 'vesicle-mediated transport']['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']
Transmembrane protein 106B
253
Transmembrane protein 106B
214
9.1
63
0.17
Q9NUM4Q9NUM4['dendrite morphogenesis', 'lysosomal lumen acidification', 'lysosomal protein catabolic process', 'lysosomal transport', 'lysosome localization', 'lysosome organization', 'neuron cellular homeostasis', 'positive regulation of dendrite development', 'positive regulation of hydrolase activity', 'regulation of lysosome organization']['dendrite morphogenesis', 'lysosomal lumen acidification', 'lysosomal protein catabolic process', 'lysosomal transport', 'lysosome localization', 'lysosome organization', 'neuron cellular homeostasis', 'positive regulation of dendrite development', 'positive regulation of hydrolase activity', 'regulation of lysosome organization']
Stimulator of interferon genes protein
148
Stimulator of interferon genes protein
148
5.3
66
0.29
A0A2R3XZB7A0A2R3XZB7['activation of innate immune response', 'positive regulation of type I interferon production']['activation of innate immune response', 'positive regulation of type I interferon production']
Calcium homeostasis modulator protein 4
83
Calcium homeostasis modulator protein 4
209
3.9
nan
nan
Q5JW98Q5JW98[][]
Glutamate receptor 2
610
Glutamate receptor 2
610
8.5
82
0.14
P19491P19491['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']
Potassium voltage-gated channel subfamily D member 2
132
Potassium voltage-gated channel subfamily D member 2
111
3.8
68
0.39
Q9NZV8Q9NZV8['action potential', 'cellular response to hypoxia', 'chemical synaptic transmission', 'locomotor rhythm', 'neuronal action potential', 'potassium ion transmembrane transport', 'protein homooligomerization', 'regulation of ion transmembrane transport', 'sensory perception of pain']['action potential', 'cellular response to hypoxia', 'chemical synaptic transmission', 'locomotor rhythm', 'neuronal action potential', 'potassium ion transmembrane transport', 'protein homooligomerization', 'regulation of ion transmembrane transport', 'sensory perception of pain']
Choline transporter-like protein 1
485
Choline transporter-like protein 1
485
5.8
42
0.41
Q8WWI5Q8WWI5['choline catabolic process', 'choline transport', 'phosphatidylcholine biosynthetic process', 'transmembrane transport', 'transport across blood-brain barrier']['choline catabolic process', 'choline transport', 'phosphatidylcholine biosynthetic process', 'transmembrane transport', 'transport across blood-brain barrier']
Calcium homeostasis modulator protein 4
83
Calcium homeostasis modulator protein 4
205
9.7
nan
nan
Q5JW98Q5JW98[][]
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
194
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
155
9.2
99
0.11
Q9DC70Q8K3J1['aerobic respiration', 'electron transport coupled proton transport', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'proton motive force-driven mitochondrial ATP synthesis']['aerobic respiration', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'proton motive force-driven mitochondrial ATP synthesis', 'response to oxidative stress']
Glutamate receptor 2
549
Protein cornichon homolog 2
9
6.4
83
0.19
P19491Q5BJU5['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']['localization within membrane', 'negative regulation of anterograde synaptic vesicle transport', 'negative regulation of receptor localization to synapse', 'regulation of AMPA receptor activity', 'regulation of membrane potential', 'regulation of NMDA receptor activity', 'regulation of postsynaptic neurotransmitter receptor activity', 'synaptic transmission, glutamatergic', 'vesicle-mediated transport']
Immunoglobulin heavy constant mu
291
Immunoglobulin heavy constant mu
291
2.0
49
1.0
P01871P01871['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
Glutamate receptor ionotropic, kainate 2
595
Glutamate receptor ionotropic, kainate 2
595
8.5
33
0.36
P42260P42260['behavioral fear response', 'cellular calcium ion homeostasis', 'chemical synaptic transmission', 'detection of cold stimulus involved in thermoception', 'excitatory postsynaptic potential', 'inhibitory postsynaptic potential', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of synaptic transmission, glutamatergic', 'neuron apoptotic process', 'neuronal action potential', 'positive regulation of neuron apoptotic process', 'positive regulation of synaptic transmission', 'presynaptic modulation of chemical synaptic transmission', 'receptor clustering', 'regulation of JNK cascade', 'regulation of long-term neuronal synaptic plasticity', 'regulation of membrane potential', 'regulation of short-term neuronal synaptic plasticity', 'synaptic transmission, glutamatergic']['behavioral fear response', 'cellular calcium ion homeostasis', 'chemical synaptic transmission', 'detection of cold stimulus involved in thermoception', 'excitatory postsynaptic potential', 'inhibitory postsynaptic potential', 'modulation of chemical synaptic transmission', 'negative regulation of neuron apoptotic process', 'negative regulation of synaptic transmission, glutamatergic', 'neuron apoptotic process', 'neuronal action potential', 'positive regulation of neuron apoptotic process', 'positive regulation of synaptic transmission', 'presynaptic modulation of chemical synaptic transmission', 'receptor clustering', 'regulation of JNK cascade', 'regulation of long-term neuronal synaptic plasticity', 'regulation of membrane potential', 'regulation of short-term neuronal synaptic plasticity', 'synaptic transmission, glutamatergic']
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
179
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
6.7
92
0.16
Q9D6J6Q91YT0['aerobic respiration', 'cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development', 'proton motive force-driven mitochondrial ATP synthesis']['aerobic respiration', 'mitochondrial ATP synthesis coupled electron transport', 'mitochondrial electron transport, NADH to ubiquinone', 'proton motive force-driven mitochondrial ATP synthesis']
T-cell surface glycoprotein CD3 epsilon chain
122
T-cell surface glycoprotein CD3 gamma chain
107
5.8
49
0.35
P07766P09693['adaptive immune response', 'alpha-beta T cell activation', 'apoptotic signaling pathway', 'calcium-mediated signaling', 'CD4-positive, alpha-beta T cell proliferation', 'cell surface receptor signaling pathway', 'cerebellum development', 'dendrite development', 'G protein-coupled receptor signaling pathway', 'gamma-delta T cell activation', 'negative regulation of gene expression', 'negative regulation of smoothened signaling pathway', 'negative thymic T cell selection', 'peptidyl-tyrosine phosphorylation', 'positive regulation of calcium-mediated signaling', 'positive regulation of CD4-positive, alpha-beta T cell proliferation', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cell-matrix adhesion', 'positive regulation of gene expression', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-2 production', 'positive regulation of interleukin-4 production', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of T cell anergy', 'positive regulation of T cell proliferation', 'positive thymic T cell selection', 'protein-containing complex assembly', 'regulation of apoptotic process', 'signal complex assembly', 'smoothened signaling pathway', 'T cell activation', 'T cell anergy', 'T cell costimulation', 'T cell receptor signaling pathway', 'transmembrane receptor protein tyrosine kinase signaling pathway']['adaptive immune response', 'alpha-beta T cell activation', 'cell surface receptor signaling pathway', 'establishment or maintenance of cell polarity', 'gamma-delta T cell activation', 'positive thymic T cell selection', 'protein transport', 'protein-containing complex assembly', 'regulation of lymphocyte apoptotic process', 'T cell activation', 'T cell receptor signaling pathway']
NADH-ubiquinone oxidoreductase chain 6
16
NADH-ubiquinone oxidoreductase chain 4L
32
8.0
98
0.13
P03925P03903['aerobic respiration', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'proton motive force-driven mitochondrial ATP synthesis', 'response to cocaine', 'response to hydrogen peroxide', 'response to nicotine']['aerobic respiration', 'ATP synthesis coupled electron transport', 'proton motive force-driven mitochondrial ATP synthesis']
RNA polymerase II elongation factor ELL2
19
ELL-associated factor 1
46
8.6
nan
nan
O00472Q96JC9['positive regulation of transcription elongation from RNA polymerase II promoter', 'snRNA transcription by RNA polymerase II', 'transcription elongation from RNA polymerase II promoter']['positive regulation of transcription, DNA-templated', 'regulation of transcription elongation from RNA polymerase II promoter']
Microtubule-associated protein tau
608
Microtubule-associated protein tau
608
9.8
67
0.15
P10636P10636['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'amyloid fibril formation', 'astrocyte activation', 'axon development', 'axonal transport', 'axonal transport of mitochondrion', 'cell-cell signaling', 'cellular response to brain-derived neurotrophic factor stimulus', 'cellular response to heat', 'cellular response to nerve growth factor stimulus', 'cellular response to reactive oxygen species', 'central nervous system neuron development', 'cytoplasmic microtubule organization', 'generation of neurons', 'internal protein amino acid acetylation', 'intracellular distribution of mitochondria', 'learning or memory', 'memory', 'microglial cell activation', 'microtubule cytoskeleton organization', 'microtubule polymerization', 'negative regulation of establishment of protein localization to mitochondrion', 'negative regulation of gene expression', 'negative regulation of kinase activity', 'negative regulation of mitochondrial fission', 'negative regulation of mitochondrial membrane potential', 'negative regulation of tubulin deacetylation', 'neurofibrillary tangle assembly', 'neuron projection development', 'plus-end-directed organelle transport along microtubule', 'positive regulation of axon extension', 'positive regulation of diacylglycerol kinase activity', 'positive regulation of microtubule polymerization', 'positive regulation of neuron death', 'positive regulation of protein localization', 'positive regulation of protein localization to synapse', 'positive regulation of superoxide anion generation', 'protein homooligomerization', 'protein polymerization', 'regulation of autophagy', 'regulation of calcium-mediated signaling', 'regulation of cellular response to heat', 'regulation of chromosome organization', 'regulation of long-term synaptic depression', 'regulation of microtubule cytoskeleton organization', 'regulation of microtubule polymerization', 'regulation of microtubule polymerization or depolymerization', 'regulation of mitochondrial fission', 'regulation of response to DNA damage stimulus', 'regulation of synaptic plasticity', 'response to lead ion', 'rRNA metabolic process', 'stress granule assembly', 'supramolecular fiber organization', 'synapse assembly', 'synapse organization']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'amyloid fibril formation', 'astrocyte activation', 'axon development', 'axonal transport', 'axonal transport of mitochondrion', 'cell-cell signaling', 'cellular response to brain-derived neurotrophic factor stimulus', 'cellular response to heat', 'cellular response to nerve growth factor stimulus', 'cellular response to reactive oxygen species', 'central nervous system neuron development', 'cytoplasmic microtubule organization', 'generation of neurons', 'internal protein amino acid acetylation', 'intracellular distribution of mitochondria', 'learning or memory', 'memory', 'microglial cell activation', 'microtubule cytoskeleton organization', 'microtubule polymerization', 'negative regulation of establishment of protein localization to mitochondrion', 'negative regulation of gene expression', 'negative regulation of kinase activity', 'negative regulation of mitochondrial fission', 'negative regulation of mitochondrial membrane potential', 'negative regulation of tubulin deacetylation', 'neurofibrillary tangle assembly', 'neuron projection development', 'plus-end-directed organelle transport along microtubule', 'positive regulation of axon extension', 'positive regulation of diacylglycerol kinase activity', 'positive regulation of microtubule polymerization', 'positive regulation of neuron death', 'positive regulation of protein localization', 'positive regulation of protein localization to synapse', 'positive regulation of superoxide anion generation', 'protein homooligomerization', 'protein polymerization', 'regulation of autophagy', 'regulation of calcium-mediated signaling', 'regulation of cellular response to heat', 'regulation of chromosome organization', 'regulation of long-term synaptic depression', 'regulation of microtubule cytoskeleton organization', 'regulation of microtubule polymerization', 'regulation of microtubule polymerization or depolymerization', 'regulation of mitochondrial fission', 'regulation of response to DNA damage stimulus', 'regulation of synaptic plasticity', 'response to lead ion', 'rRNA metabolic process', 'stress granule assembly', 'supramolecular fiber organization', 'synapse assembly', 'synapse organization']
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
177
5.8
102
0.17
W5PUX0W5NRY1['mitochondrial ATP synthesis coupled electron transport'][]
Immunoglobulin heavy constant alpha 2
110
Immunoglobulin heavy constant alpha 2
167
2.0
nan
nan
P01877P01877['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']
Endophilin-B1
226
Endophilin-B1
121
9.5
72
0.15
Q9Y371Q9Y371['apoptotic process', 'autophagic cell death', 'autophagy', 'cellular response to amino acid starvation', 'cellular response to glucose starvation', 'membrane fission', 'membrane organization', 'positive regulation of autophagosome assembly', 'positive regulation of autophagy', 'positive regulation of membrane tubulation', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of protein-containing complex assembly', 'protein localization to vacuolar membrane', 'receptor catabolic process', 'regulation of cytokinesis', 'regulation of macroautophagy', 'regulation of protein stability']['apoptotic process', 'autophagic cell death', 'autophagy', 'cellular response to amino acid starvation', 'cellular response to glucose starvation', 'membrane fission', 'membrane organization', 'positive regulation of autophagosome assembly', 'positive regulation of autophagy', 'positive regulation of membrane tubulation', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of protein-containing complex assembly', 'protein localization to vacuolar membrane', 'receptor catabolic process', 'regulation of cytokinesis', 'regulation of macroautophagy', 'regulation of protein stability']
Calcium homeostasis modulator protein 4
210
Calcium homeostasis modulator protein 4
83
8.6
nan
nan
Q5JW98Q5JW98[][]
Zinc transporter 8
361
Zinc transporter 8
53
7.3
56
0.25
Q8IWU4Q8IWU4['cellular zinc ion homeostasis', 'insulin processing', 'insulin secretion', 'positive regulation of insulin secretion', 'regulation of sequestering of zinc ion', 'regulation of vesicle-mediated transport', 'response to glucose', 'response to interferon-gamma', 'response to interleukin-1', 'response to zinc ion', 'sequestering of zinc ion', 'zinc ion transmembrane transport', 'zinc ion transport']['cellular zinc ion homeostasis', 'insulin processing', 'insulin secretion', 'positive regulation of insulin secretion', 'regulation of sequestering of zinc ion', 'regulation of vesicle-mediated transport', 'response to glucose', 'response to interferon-gamma', 'response to interleukin-1', 'response to zinc ion', 'sequestering of zinc ion', 'zinc ion transmembrane transport', 'zinc ion transport']
Broad substrate specificity ATP-binding cassette transporter ABCG2
603
Broad substrate specificity ATP-binding cassette transporter ABCG2
603
2.0
34
1.44
Q9UNQ0Q9UNQ0['biotin transport', 'cellular detoxification', 'export across plasma membrane', 'lipid transport', 'organic anion transport', 'renal urate salt excretion', 'riboflavin transport', 'transepithelial transport', 'transmembrane transport', 'transport across blood-brain barrier', 'urate metabolic process', 'xenobiotic transport across blood-brain barrier']['biotin transport', 'cellular detoxification', 'export across plasma membrane', 'lipid transport', 'organic anion transport', 'renal urate salt excretion', 'riboflavin transport', 'transepithelial transport', 'transmembrane transport', 'transport across blood-brain barrier', 'urate metabolic process', 'xenobiotic transport across blood-brain barrier']
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
478
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
478
5.9
94
0.18
Q9Y3Q4Q9Y3Q4['blood circulation', 'cation transport', 'cellular response to cAMP', 'cellular response to cGMP', 'membrane depolarization during cardiac muscle cell action potential', 'membrane depolarization during SA node cell action potential', 'muscle contraction', 'potassium ion import across plasma membrane', 'potassium ion transmembrane transport', 'regulation of cardiac muscle cell action potential involved in regulation of contraction', 'regulation of cardiac muscle contraction', 'regulation of cation channel activity', 'regulation of heart rate', 'regulation of heart rate by cardiac conduction', 'regulation of membrane depolarization', 'regulation of membrane potential', 'regulation of SA node cell action potential', 'SA node cell action potential', 'sinoatrial node development', 'sodium ion import across plasma membrane', 'sodium ion transmembrane transport']['blood circulation', 'cation transport', 'cellular response to cAMP', 'cellular response to cGMP', 'membrane depolarization during cardiac muscle cell action potential', 'membrane depolarization during SA node cell action potential', 'muscle contraction', 'potassium ion import across plasma membrane', 'potassium ion transmembrane transport', 'regulation of cardiac muscle cell action potential involved in regulation of contraction', 'regulation of cardiac muscle contraction', 'regulation of cation channel activity', 'regulation of heart rate', 'regulation of heart rate by cardiac conduction', 'regulation of membrane depolarization', 'regulation of membrane potential', 'regulation of SA node cell action potential', 'SA node cell action potential', 'sinoatrial node development', 'sodium ion import across plasma membrane', 'sodium ion transmembrane transport']
Inosine-5'-monophosphate dehydrogenase 2
468
Inosine-5'-monophosphate dehydrogenase 2
339
8.7
96
0.12
P12268P12268["'de novo' XMP biosynthetic process", 'cellular response to interleukin-4', 'circadian rhythm', 'GMP biosynthetic process', 'GTP biosynthetic process', 'lymphocyte proliferation', 'retina development in camera-type eye']["'de novo' XMP biosynthetic process", 'cellular response to interleukin-4', 'circadian rhythm', 'GMP biosynthetic process', 'GTP biosynthetic process', 'lymphocyte proliferation', 'retina development in camera-type eye']
Insulin receptor
714
Insulin receptor
711
2.0
nan
nan
P15208P15208['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'animal organ morphogenesis', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'male gonad development', 'male sex determination', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of protein phosphorylation', 'negative regulation of transporter activity', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of hydrogen peroxide metabolic process', 'regulation of transcription, DNA-templated', 'response to nutrient levels', 'response to tumor necrosis factor', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'viral entry into host cell']['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'animal organ morphogenesis', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'male gonad development', 'male sex determination', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of protein phosphorylation', 'negative regulation of transporter activity', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of hydrogen peroxide metabolic process', 'regulation of transcription, DNA-templated', 'response to nutrient levels', 'response to tumor necrosis factor', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'viral entry into host cell']
B-cell lymphoma/leukemia 10
57
B-cell lymphoma/leukemia 10
57
9.8
46
0.22
O95999O95999['adaptive immune response', 'antifungal innate immune response', 'B cell apoptotic process', 'cell death', 'cellular defense response', 'cellular response to lipopolysaccharide', 'cellular response to mechanical stimulus', 'I-kappaB kinase/NF-kappaB signaling', 'immunoglobulin mediated immune response', 'innate immune response', 'lipopolysaccharide-mediated signaling pathway', 'negative regulation of mature B cell apoptotic process', 'neural tube closure', 'positive regulation of apoptotic process', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of kinase activity', 'positive regulation of lymphotoxin A production', 'positive regulation of mast cell cytokine production', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of phosphorylation', 'positive regulation of protein ubiquitination', 'positive regulation of T cell activation', 'positive regulation of T cell receptor signaling pathway', 'positive regulation of transcription, DNA-templated', 'protein homooligomerization', 'response to food', 'T cell apoptotic process', 'T cell receptor signaling pathway', 'toll-like receptor signaling pathway']['adaptive immune response', 'antifungal innate immune response', 'B cell apoptotic process', 'cell death', 'cellular defense response', 'cellular response to lipopolysaccharide', 'cellular response to mechanical stimulus', 'I-kappaB kinase/NF-kappaB signaling', 'immunoglobulin mediated immune response', 'innate immune response', 'lipopolysaccharide-mediated signaling pathway', 'negative regulation of mature B cell apoptotic process', 'neural tube closure', 'positive regulation of apoptotic process', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'positive regulation of interleukin-6 production', 'positive regulation of interleukin-8 production', 'positive regulation of kinase activity', 'positive regulation of lymphotoxin A production', 'positive regulation of mast cell cytokine production', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of phosphorylation', 'positive regulation of protein ubiquitination', 'positive regulation of T cell activation', 'positive regulation of T cell receptor signaling pathway', 'positive regulation of transcription, DNA-templated', 'protein homooligomerization', 'response to food', 'T cell apoptotic process', 'T cell receptor signaling pathway', 'toll-like receptor signaling pathway']
DNA-directed RNA polymerase II subunit RPB1
641
Transcription elongation factor A protein 1
301
5.3
nan
nan
P24928P23193['DNA-templated transcription, termination', 'positive regulation of RNA splicing', 'regulation of transcription, DNA-templated', 'transcription by RNA polymerase II']['positive regulation of transcription by RNA polymerase II', 'transcription by RNA polymerase II', 'transcription elongation from RNA polymerase II promoter', 'transcription, DNA-templated']
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
358
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
358
8.2
90
0.14
O60741O60741['apical protein localization', 'cellular response to cAMP', 'negative regulation of synaptic transmission, glutamatergic', 'potassium ion transmembrane transport', 'protein homotetramerization', 'regulation of cation channel activity', 'regulation of heart rate by cardiac conduction', 'regulation of membrane depolarization', 'regulation of membrane potential', 'regulation of SA node cell action potential', 'retinal cone cell development', 'sodium ion transmembrane transport']['apical protein localization', 'cellular response to cAMP', 'negative regulation of synaptic transmission, glutamatergic', 'potassium ion transmembrane transport', 'protein homotetramerization', 'regulation of cation channel activity', 'regulation of heart rate by cardiac conduction', 'regulation of membrane depolarization', 'regulation of membrane potential', 'regulation of SA node cell action potential', 'retinal cone cell development', 'sodium ion transmembrane transport']
Immunoglobulin heavy constant alpha 1
180
Immunoglobulin heavy constant alpha 1
122
3.8
nan
nan
P01876P01876['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']
Glycoprotein hormones alpha chain
31
Thyrotropin subunit beta
105
8.4
nan
nan
P01215P01222['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['anatomical structure morphogenesis', 'cell-cell signaling', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'response to calcium ion', 'response to estrogen', 'response to vitamin A']
Calcium homeostasis modulator protein 2
86
Calcium homeostasis modulator protein 2
204
9.9
nan
nan
Q9HA72Q9HA72['positive regulation of apoptotic process']['positive regulation of apoptotic process']
DNA-directed RNA polymerase III subunit RPC2
924
DNA-directed RNA polymerases I, II, and III subunit RPABC5
44
8.0
91
0.14
Q9NW08P62875['defense response to virus', 'innate immune response', 'positive regulation of innate immune response', 'positive regulation of interferon-beta production', 'transcription, DNA-templated']['regulation of transcription by RNA polymerase I', 'transcription by RNA polymerase I', 'transcription by RNA polymerase II', 'tRNA transcription by RNA polymerase III']
Bestrophin
108
Bestrophin
185
5.8
102
0.17
E1BF86E1BF86[][]
SWI/SNF complex subunit SMARCC2
486
Zinc finger protein ubi-d4
24
5.3
90
0.21
Q8TAQ2Q92785['chromatin remodeling', 'negative regulation of transcription, DNA-templated', 'nervous system development', 'nucleosome disassembly', 'positive regulation of cell differentiation', 'positive regulation of double-strand break repair', 'positive regulation of myoblast differentiation', 'positive regulation of T cell differentiation', 'positive regulation of transcription, DNA-templated', 'regulation of G0 to G1 transition', 'regulation of G1/S transition of mitotic cell cycle', 'regulation of mitotic metaphase/anaphase transition', 'regulation of nucleotide-excision repair', 'regulation of transcription by RNA polymerase II']['apoptotic process', 'apoptotic signaling pathway', 'chromatin remodeling', 'negative regulation of myeloid progenitor cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'nervous system development', 'positive regulation of double-strand break repair', 'positive regulation of stem cell population maintenance', 'positive regulation of transcription by RNA polymerase II', 'regulation of G0 to G1 transition', 'regulation of G1/S transition of mitotic cell cycle', 'regulation of mitotic metaphase/anaphase transition', 'regulation of nucleotide-excision repair', 'regulation of transcription by RNA polymerase II']
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
N-formyl peptide receptor 2
63
9.1
81
0.14
P63096P25090['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell cycle', 'cell division', 'cellular response to forskolin', 'G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to cell cortex', 'regulation of cAMP-mediated signaling', 'regulation of mitotic spindle organization', 'response to peptide hormone']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'astrocyte activation', 'calcium-mediated signaling', 'cell adhesion', 'cell surface receptor signaling pathway', 'cellular response to amyloid-beta', 'chemotaxis', 'complement receptor mediated signaling pathway', 'defense response to bacterium', 'G protein-coupled receptor signaling pathway', 'immune response-regulating cell surface receptor signaling pathway', 'inflammatory response', 'microglial cell activation', 'negative regulation of inflammatory response', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive chemotaxis', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of innate immune response', 'positive regulation of monocyte chemotaxis', 'positive regulation of phagocytosis', 'positive regulation of protein phosphorylation', 'positive regulation of superoxide anion generation', 'receptor-mediated endocytosis']
Glutamate receptor 2
78
Glutamate receptor 1
75
8.0
72
0.17
P19491P19490['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']['cellular response to amine stimulus', 'cellular response to amino acid stimulus', 'cellular response to ammonium ion', 'cellular response to dsRNA', 'cellular response to growth factor stimulus', 'cellular response to organic cyclic compound', 'cellular response to peptide hormone stimulus', 'chemical synaptic transmission', 'long-term memory', 'long-term synaptic depression', 'modulation of chemical synaptic transmission', 'neuronal action potential', 'positive regulation of membrane potential', 'positive regulation of synaptic transmission', 'receptor internalization', 'regulation of postsynaptic membrane potential', 'regulation of receptor recycling', 'regulation of synaptic plasticity', 'response to arsenic-containing substance', 'response to cocaine', 'response to electrical stimulus', 'response to estradiol', 'response to fungicide', 'response to lithium ion', 'response to organic cyclic compound', 'response to peptide hormone', 'response to toxic substance', 'response to xenobiotic stimulus', 'spinal cord development', 'synaptic transmission, glutamatergic']
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
154
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
166
8.7
97
0.12
A0A287BDC0I3LK43[][]
Potassium voltage-gated channel, Shaw-related subfamily, member 1
83
Potassium voltage-gated channel, Shaw-related subfamily, member 1
78
6.4
78
0.2
Q3KNS8Q3KNS8['protein homooligomerization', 'regulation of ion transmembrane transport']['protein homooligomerization', 'regulation of ion transmembrane transport']
Transcription initiation factor TFIID subunit 5
577
Transcription initiation factor TFIID subunit 9
121
9.8
74
0.14
Q15542Q16594['DNA-templated transcription, initiation', 'histone H3 acetylation', 'monoubiquitinated histone deubiquitination', 'monoubiquitinated histone H2A deubiquitination', 'mRNA transcription by RNA polymerase II', 'positive regulation of transcription initiation from RNA polymerase II promoter', 'positive regulation of transcription, DNA-templated', 'protein phosphorylation', 'regulation of DNA repair', 'regulation of transcription by RNA polymerase II', 'RNA polymerase II preinitiation complex assembly', 'transcription initiation from RNA polymerase II promoter']['box C/D snoRNP assembly', 'cellular response to DNA damage stimulus', 'histone acetylation', 'histone H3 acetylation', 'monoubiquitinated histone deubiquitination', 'monoubiquitinated histone H2A deubiquitination', 'mRNA transcription by RNA polymerase II', 'negative regulation of apoptotic process', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'negative regulation of proteasomal ubiquitin-dependent protein catabolic process', 'positive regulation of response to cytokine stimulus', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription initiation from RNA polymerase II promoter', 'positive regulation of transcription, DNA-templated', 'protein phosphorylation', 'protein stabilization', 'regulation of DNA repair', 'regulation of RNA splicing', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'response to interleukin-1', 'response to L-glutamate', 'RNA polymerase II preinitiation complex assembly']
Microtubule-associated protein tau
639
Microtubule-associated protein tau
639
6.6
52
0.29
P10636P10636['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'amyloid fibril formation', 'astrocyte activation', 'axon development', 'axonal transport', 'axonal transport of mitochondrion', 'cell-cell signaling', 'cellular response to brain-derived neurotrophic factor stimulus', 'cellular response to heat', 'cellular response to nerve growth factor stimulus', 'cellular response to reactive oxygen species', 'central nervous system neuron development', 'cytoplasmic microtubule organization', 'generation of neurons', 'internal protein amino acid acetylation', 'intracellular distribution of mitochondria', 'learning or memory', 'memory', 'microglial cell activation', 'microtubule cytoskeleton organization', 'microtubule polymerization', 'negative regulation of establishment of protein localization to mitochondrion', 'negative regulation of gene expression', 'negative regulation of kinase activity', 'negative regulation of mitochondrial fission', 'negative regulation of mitochondrial membrane potential', 'negative regulation of tubulin deacetylation', 'neurofibrillary tangle assembly', 'neuron projection development', 'plus-end-directed organelle transport along microtubule', 'positive regulation of axon extension', 'positive regulation of diacylglycerol kinase activity', 'positive regulation of microtubule polymerization', 'positive regulation of neuron death', 'positive regulation of protein localization', 'positive regulation of protein localization to synapse', 'positive regulation of superoxide anion generation', 'protein homooligomerization', 'protein polymerization', 'regulation of autophagy', 'regulation of calcium-mediated signaling', 'regulation of cellular response to heat', 'regulation of chromosome organization', 'regulation of long-term synaptic depression', 'regulation of microtubule cytoskeleton organization', 'regulation of microtubule polymerization', 'regulation of microtubule polymerization or depolymerization', 'regulation of mitochondrial fission', 'regulation of response to DNA damage stimulus', 'regulation of synaptic plasticity', 'response to lead ion', 'rRNA metabolic process', 'stress granule assembly', 'supramolecular fiber organization', 'synapse assembly', 'synapse organization']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'amyloid fibril formation', 'astrocyte activation', 'axon development', 'axonal transport', 'axonal transport of mitochondrion', 'cell-cell signaling', 'cellular response to brain-derived neurotrophic factor stimulus', 'cellular response to heat', 'cellular response to nerve growth factor stimulus', 'cellular response to reactive oxygen species', 'central nervous system neuron development', 'cytoplasmic microtubule organization', 'generation of neurons', 'internal protein amino acid acetylation', 'intracellular distribution of mitochondria', 'learning or memory', 'memory', 'microglial cell activation', 'microtubule cytoskeleton organization', 'microtubule polymerization', 'negative regulation of establishment of protein localization to mitochondrion', 'negative regulation of gene expression', 'negative regulation of kinase activity', 'negative regulation of mitochondrial fission', 'negative regulation of mitochondrial membrane potential', 'negative regulation of tubulin deacetylation', 'neurofibrillary tangle assembly', 'neuron projection development', 'plus-end-directed organelle transport along microtubule', 'positive regulation of axon extension', 'positive regulation of diacylglycerol kinase activity', 'positive regulation of microtubule polymerization', 'positive regulation of neuron death', 'positive regulation of protein localization', 'positive regulation of protein localization to synapse', 'positive regulation of superoxide anion generation', 'protein homooligomerization', 'protein polymerization', 'regulation of autophagy', 'regulation of calcium-mediated signaling', 'regulation of cellular response to heat', 'regulation of chromosome organization', 'regulation of long-term synaptic depression', 'regulation of microtubule cytoskeleton organization', 'regulation of microtubule polymerization', 'regulation of microtubule polymerization or depolymerization', 'regulation of mitochondrial fission', 'regulation of response to DNA damage stimulus', 'regulation of synaptic plasticity', 'response to lead ion', 'rRNA metabolic process', 'stress granule assembly', 'supramolecular fiber organization', 'synapse assembly', 'synapse organization']
P2X purinoceptor 7
362
P2X purinoceptor 7
4
5.8
nan
nan
Q64663Q64663['apoptotic signaling pathway', 'ATP export', 'bleb assembly', 'calcium ion transport', 'cation transport', 'cell death', 'cell morphogenesis', 'cell surface receptor signaling pathway', 'cell volume homeostasis', 'cellular response to dsRNA', 'cellular response to extracellular stimulus', 'cellular response to organic cyclic compound', 'ceramide biosynthetic process', 'collagen metabolic process', 'defense response to Gram-positive bacterium', 'extrinsic apoptotic signaling pathway', 'gene expression', 'homeostasis of number of cells within a tissue', 'inflammatory response', 'membrane depolarization', 'membrane protein ectodomain proteolysis', 'mitochondrion organization', 'NAD transport', 'negative regulation of bone resorption', 'negative regulation of cell volume', 'negative regulation of MAPK cascade', 'neuronal action potential', 'organic cation transport', 'phagolysosome assembly', 'phospholipid transfer to membrane', 'phospholipid translocation', 'plasma membrane organization', 'plasma membrane phospholipid scrambling', 'pore complex assembly', 'positive regulation of apoptotic process', 'positive regulation of bleb assembly', 'positive regulation of bone mineralization', 'positive regulation of calcium ion transport into cytosol', 'positive regulation of catalytic activity', 'positive regulation of cytokine production', 'positive regulation of cytoskeleton organization', 'positive regulation of gamma-aminobutyric acid secretion', 'positive regulation of gene expression', 'positive regulation of glutamate secretion', 'positive regulation of glycolytic process', 'positive regulation of interleukin-1 alpha production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of ion transmembrane transport', 'positive regulation of lymphocyte apoptotic process', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mitochondrial depolarization', 'positive regulation of ossification', 'positive regulation of prostaglandin secretion', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of T cell mediated cytotoxicity', 'programmed cell death', 'protein catabolic process', 'protein phosphorylation', 'protein processing', 'purinergic nucleotide receptor signaling pathway', 'reactive oxygen species metabolic process', 'regulation of presynaptic dense core granule exocytosis', 'regulation of sodium ion transport', 'release of sequestered calcium ion into cytosol', 'response to ATP', 'response to bacterium', 'response to calcium ion', 'response to electrical stimulus', 'response to fluid shear stress', 'response to lipopolysaccharide', 'response to mechanical stimulus', 'response to organic cyclic compound', 'response to organic substance', 'response to xenobiotic stimulus', 'response to zinc ion', 'sensory perception of pain', 'skeletal system morphogenesis', 'synaptic vesicle exocytosis', 'T cell homeostasis', 'T cell proliferation', 'vesicle budding from membrane']['apoptotic signaling pathway', 'ATP export', 'bleb assembly', 'calcium ion transport', 'cation transport', 'cell death', 'cell morphogenesis', 'cell surface receptor signaling pathway', 'cell volume homeostasis', 'cellular response to dsRNA', 'cellular response to extracellular stimulus', 'cellular response to organic cyclic compound', 'ceramide biosynthetic process', 'collagen metabolic process', 'defense response to Gram-positive bacterium', 'extrinsic apoptotic signaling pathway', 'gene expression', 'homeostasis of number of cells within a tissue', 'inflammatory response', 'membrane depolarization', 'membrane protein ectodomain proteolysis', 'mitochondrion organization', 'NAD transport', 'negative regulation of bone resorption', 'negative regulation of cell volume', 'negative regulation of MAPK cascade', 'neuronal action potential', 'organic cation transport', 'phagolysosome assembly', 'phospholipid transfer to membrane', 'phospholipid translocation', 'plasma membrane organization', 'plasma membrane phospholipid scrambling', 'pore complex assembly', 'positive regulation of apoptotic process', 'positive regulation of bleb assembly', 'positive regulation of bone mineralization', 'positive regulation of calcium ion transport into cytosol', 'positive regulation of catalytic activity', 'positive regulation of cytokine production', 'positive regulation of cytoskeleton organization', 'positive regulation of gamma-aminobutyric acid secretion', 'positive regulation of gene expression', 'positive regulation of glutamate secretion', 'positive regulation of glycolytic process', 'positive regulation of interleukin-1 alpha production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of ion transmembrane transport', 'positive regulation of lymphocyte apoptotic process', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mitochondrial depolarization', 'positive regulation of ossification', 'positive regulation of prostaglandin secretion', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of T cell mediated cytotoxicity', 'programmed cell death', 'protein catabolic process', 'protein phosphorylation', 'protein processing', 'purinergic nucleotide receptor signaling pathway', 'reactive oxygen species metabolic process', 'regulation of presynaptic dense core granule exocytosis', 'regulation of sodium ion transport', 'release of sequestered calcium ion into cytosol', 'response to ATP', 'response to bacterium', 'response to calcium ion', 'response to electrical stimulus', 'response to fluid shear stress', 'response to lipopolysaccharide', 'response to mechanical stimulus', 'response to organic cyclic compound', 'response to organic substance', 'response to xenobiotic stimulus', 'response to zinc ion', 'sensory perception of pain', 'skeletal system morphogenesis', 'synaptic vesicle exocytosis', 'T cell homeostasis', 'T cell proliferation', 'vesicle budding from membrane']
Glycoprotein hormones alpha chain
55
Choriogonadotropin subunit beta 3
77
9.5
84
0.13
P01215P0DN86['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['apoptotic process', 'cell-cell signaling', 'female gamete generation', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'signal transduction']
von Willebrand factor
1097
von Willebrand factor
1097
2.0
74
0.67
P04275P04275['blood coagulation', 'cell adhesion', 'cell-substrate adhesion', 'hemostasis', 'platelet activation', 'positive regulation of intracellular signal transduction', 'response to wounding']['blood coagulation', 'cell adhesion', 'cell-substrate adhesion', 'hemostasis', 'platelet activation', 'positive regulation of intracellular signal transduction', 'response to wounding']
Dynactin subunit 6
128
Dynactin subunit 5
149
5.3
78
0.24
D0G6S1A0A286ZK88['mitotic spindle organization']['aorta development', 'coronary vasculature development', 'ventricular septum development']
Igh protein
308
Igh protein
249
9.5
nan
nan
Q99M22Q99M22[][]
Igh protein
308
Igh protein
306
5.4
51
0.36
Q99M22Q99M22[][]
Transient receptor potential cation channel subfamily V member 1
623
Transient receptor potential cation channel subfamily V member 1
623
6.4
54
0.29
I3LZN5I3LZN5['behavioral response to pain', 'calcium ion import across plasma membrane', 'cellular response to acidic pH', 'cellular response to heat', 'detection of chemical stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in thermoception', 'diet induced thermogenesis', 'fever generation', 'lipid metabolic process', 'negative regulation of transcription by RNA polymerase II', 'peptide secretion', 'response to capsazepine', 'sensory perception of mechanical stimulus', 'smooth muscle contraction involved in micturition']['behavioral response to pain', 'calcium ion import across plasma membrane', 'cellular response to acidic pH', 'cellular response to heat', 'detection of chemical stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in thermoception', 'diet induced thermogenesis', 'fever generation', 'lipid metabolic process', 'negative regulation of transcription by RNA polymerase II', 'peptide secretion', 'response to capsazepine', 'sensory perception of mechanical stimulus', 'smooth muscle contraction involved in micturition']
Ig kappa-b4 chain C region
103
IgG heavy chain VDJ region
134
6.7
nan
nan
P01840A0A1Y1B8B1[][]
DNA-directed RNA polymerase I subunit RPA2
93
DNA-directed RNA polymerases I, II, and III subunit RPABC4
36
9.8
62
0.16
Q9H9Y6P53803['embryo implantation', 'neural crest formation', 'nucleologenesis', 'rRNA transcription']['regulation of transcription by RNA polymerase I', 'transcription by RNA polymerase II', 'transcription by RNA polymerase III']
ATP synthase F(0) complex subunit C2, mitochondrial
132
ATP synthase F(0) complex subunit C2, mitochondrial
132
5.8
94
0.18
P07926P07926['proton motive force-driven ATP synthesis']['proton motive force-driven ATP synthesis']
Calcium homeostasis modulator protein 5
203
Calcium homeostasis modulator protein 5
81
5.8
47
0.37
Q8N5C1Q8N5C1[][]
Glycoprotein hormones alpha chain
55
Thyrotropin subunit beta
105
9.5
70
0.15
P01215P01222['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['anatomical structure morphogenesis', 'cell-cell signaling', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'response to calcium ion', 'response to estrogen', 'response to vitamin A']
DDB1- and CUL4-associated factor 1
784
DDB1- and CUL4-associated factor 1
784
9.8
46
0.22
Q9Y4B6Q9Y4B6['B cell differentiation', 'cell competition in a multicellular organism', 'chromatin organization', 'histone H2A-T120 phosphorylation', 'negative regulation of transcription by RNA polymerase II', 'post-translational protein modification', 'protein ubiquitination', 'V(D)J recombination']['B cell differentiation', 'cell competition in a multicellular organism', 'chromatin organization', 'histone H2A-T120 phosphorylation', 'negative regulation of transcription by RNA polymerase II', 'post-translational protein modification', 'protein ubiquitination', 'V(D)J recombination']
Pentraxin-related protein PTX3
318
Pentraxin-related protein PTX3
318
5.3
68
0.28
P26022P26022['extracellular matrix organization', 'inflammatory response', 'innate immune response', 'negative regulation by host of viral exo-alpha-sialidase activity', 'negative regulation by host of viral glycoprotein metabolic process', 'negative regulation by host of viral process', 'negative regulation of exo-alpha-sialidase activity', 'negative regulation of glycoprotein metabolic process', 'negative regulation of viral entry into host cell', 'opsonization', 'ovarian cumulus expansion', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phagocytosis', 'response to yeast']['extracellular matrix organization', 'inflammatory response', 'innate immune response', 'negative regulation by host of viral exo-alpha-sialidase activity', 'negative regulation by host of viral glycoprotein metabolic process', 'negative regulation by host of viral process', 'negative regulation of exo-alpha-sialidase activity', 'negative regulation of glycoprotein metabolic process', 'negative regulation of viral entry into host cell', 'opsonization', 'ovarian cumulus expansion', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phagocytosis', 'response to yeast']
Clathrin heavy chain
1565
Clathrin light chain
178
5.8
66
0.26
C0MHR2F1S398['clathrin coat assembly', 'intracellular protein transport', 'mitotic cell cycle', 'receptor-mediated endocytosis']['clathrin-dependent endocytosis', 'intracellular protein transport']
DNA-directed RNA polymerases I and III subunit RPAC1
333
DNA-directed RNA polymerases I and III subunit RPAC2
107
5.8
73
0.24
O15160P0DPB6['transcription by RNA polymerase I']['transcription, DNA-templated']
Interleukin-25
115
Interleukin-25
170
8.7
87
0.13
Q9H293Q9H293['eosinophil differentiation', 'inflammatory response to antigenic stimulus', 'positive regulation of transcription by RNA polymerase II', 'response to fungus', 'response to nematode']['eosinophil differentiation', 'inflammatory response to antigenic stimulus', 'positive regulation of transcription by RNA polymerase II', 'response to fungus', 'response to nematode']
Sodium channel subunit beta-2
55
Sodium channel protein type 9 subunit alpha
897
9.1
58
0.19
O60939Q15858['cardiac muscle cell action potential involved in contraction', 'cardiac muscle contraction', 'chemical synaptic transmission', 'gene expression', 'membrane depolarization during cardiac muscle cell action potential', 'nervous system development', 'regulation of atrial cardiac muscle cell membrane depolarization', 'regulation of heart rate by cardiac conduction', 'regulation of sodium ion transmembrane transporter activity', 'response to heat', 'response to pyrethroid', 'sodium ion transmembrane transport']['behavioral response to formalin induced pain', 'inflammatory response', 'membrane depolarization during action potential', 'negative regulation of action potential', 'neuronal action potential', 'post-embryonic development', 'regulation of ion transmembrane transport', 'response to cold', 'response to heat', 'response to toxic substance', 'sensory perception of pain', 'sodium ion transmembrane transport', 'sodium ion transport']
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
286
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
222
7.8
99
0.13
W5PUX0W5NRY1['mitochondrial ATP synthesis coupled electron transport'][]
Glycoprotein hormones alpha chain
31
Thyrotropin subunit beta
51
7.6
nan
nan
P01215P01222['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['anatomical structure morphogenesis', 'cell-cell signaling', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'response to calcium ion', 'response to estrogen', 'response to vitamin A']
Glycoprotein hormones alpha chain
83
Choriogonadotropin subunit beta 3
113
8.5
77
0.15
P01215P0DN86['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['apoptotic process', 'cell-cell signaling', 'female gamete generation', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'signal transduction']
Bestrophin-2
185
Bestrophin-2
108
5.6
98
0.18
Q8NFU1Q8NFU1['membrane depolarization', 'sensory perception of smell']['membrane depolarization', 'sensory perception of smell']
Polymeric immunoglobulin receptor
486
Immunoglobulin heavy constant mu
291
2.0
56
0.88
P01833P01871['detection of chemical stimulus involved in sensory perception of bitter taste', 'epidermal growth factor receptor signaling pathway', 'Fc receptor signaling pathway', 'immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor', 'receptor clustering', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
General transcription factor IIH subunit 3
285
General transcription factor IIH subunit 2
247
5.3
68
0.28
Q13889Q13888['DNA repair', 'nucleotide-excision repair', 'phosphorylation of RNA polymerase II C-terminal domain', 'transcription by RNA polymerase II']['G protein-coupled receptor internalization', 'nucleotide-excision repair', 'positive regulation of DNA helicase activity', 'regulation of transcription by RNA polymerase II', 'response to UV', 'transcription by RNA polymerase II', 'transcription initiation from RNA polymerase II promoter']
Major prion protein
179
Major prion protein
179
9.8
88
0.12
P04156P04156['activation of protein kinase activity', 'calcium-mediated signaling using intracellular calcium source', 'cell cycle', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to copper ion', 'cellular response to xenobiotic stimulus', 'dendritic spine maintenance', 'learning or memory', 'long-term memory', 'negative regulation of activated T cell proliferation', 'negative regulation of amyloid precursor protein catabolic process', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of calcineurin-NFAT signaling cascade', 'negative regulation of dendritic spine maintenance', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-17 production', 'negative regulation of interleukin-2 production', 'negative regulation of long-term synaptic potentiation', 'negative regulation of protein phosphorylation', 'negative regulation of protein processing', 'negative regulation of T cell receptor signaling pathway', 'neuron projection maintenance', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein targeting to membrane', 'positive regulation of protein tyrosine kinase activity', 'protein destabilization', 'protein homooligomerization', 'regulation of calcium ion import across plasma membrane', 'regulation of glutamate receptor signaling pathway', 'regulation of intracellular calcium activated chloride channel activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of potassium ion transmembrane transport', 'response to amyloid-beta', 'response to cadmium ion', 'response to oxidative stress']['activation of protein kinase activity', 'calcium-mediated signaling using intracellular calcium source', 'cell cycle', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to copper ion', 'cellular response to xenobiotic stimulus', 'dendritic spine maintenance', 'learning or memory', 'long-term memory', 'negative regulation of activated T cell proliferation', 'negative regulation of amyloid precursor protein catabolic process', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of calcineurin-NFAT signaling cascade', 'negative regulation of dendritic spine maintenance', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-17 production', 'negative regulation of interleukin-2 production', 'negative regulation of long-term synaptic potentiation', 'negative regulation of protein phosphorylation', 'negative regulation of protein processing', 'negative regulation of T cell receptor signaling pathway', 'neuron projection maintenance', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein targeting to membrane', 'positive regulation of protein tyrosine kinase activity', 'protein destabilization', 'protein homooligomerization', 'regulation of calcium ion import across plasma membrane', 'regulation of glutamate receptor signaling pathway', 'regulation of intracellular calcium activated chloride channel activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of potassium ion transmembrane transport', 'response to amyloid-beta', 'response to cadmium ion', 'response to oxidative stress']
Uncharacterized protein
248
IGK@ protein
236
2.0
nan
nan
Q6N095Q6PIL8[][]
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
180
6.4
96
0.16
F1RVN1A0A287BG40['mitochondrial electron transport, NADH to ubiquinone']['cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development']
Inosine-5'-monophosphate dehydrogenase 1
468
Inosine-5'-monophosphate dehydrogenase 1
339
9.9
98
0.1
P20839P20839['GMP biosynthetic process', 'GTP biosynthetic process']['GMP biosynthetic process', 'GTP biosynthetic process']
Transmembrane protein 106B
214
Transmembrane protein 106B
214
9.9
72
0.14
Q9NUM4Q9NUM4['dendrite morphogenesis', 'lysosomal lumen acidification', 'lysosomal protein catabolic process', 'lysosomal transport', 'lysosome localization', 'lysosome organization', 'neuron cellular homeostasis', 'positive regulation of dendrite development', 'positive regulation of hydrolase activity', 'regulation of lysosome organization']['dendrite morphogenesis', 'lysosomal lumen acidification', 'lysosomal protein catabolic process', 'lysosomal transport', 'lysosome localization', 'lysosome organization', 'neuron cellular homeostasis', 'positive regulation of dendrite development', 'positive regulation of hydrolase activity', 'regulation of lysosome organization']
Insulin receptor
710
Insulin receptor
712
9.1
50
0.22
P06213P06213['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell']['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell']
Neuronal acetylcholine receptor subunit alpha-3
269
Neuronal acetylcholine receptor subunit beta-4
260
8.7
68
0.17
P32297P30926['acetylcholine receptor signaling pathway', 'activation of transmembrane receptor protein tyrosine kinase activity', 'behavioral response to nicotine', 'chemical synaptic transmission', 'excitatory postsynaptic potential', 'ion transmembrane transport', 'ion transport', 'locomotory behavior', 'membrane depolarization', 'nervous system development', 'nervous system process', 'regulation of acetylcholine secretion, neurotransmission', 'regulation of dendrite morphogenesis', 'regulation of membrane potential', 'regulation of smooth muscle contraction', 'response to acetylcholine', 'signal transduction', 'synaptic transmission involved in micturition', 'synaptic transmission, cholinergic']['behavioral response to nicotine', 'chemical synaptic transmission', 'ion transmembrane transport', 'ion transport', 'locomotory behavior', 'membrane depolarization', 'nervous system process', 'neuronal action potential', 'positive regulation of transmission of nerve impulse', 'regulation of membrane potential', 'regulation of neurotransmitter secretion', 'regulation of smooth muscle contraction', 'signal transduction', 'smooth muscle contraction', 'synaptic transmission involved in micturition', 'synaptic transmission, cholinergic']
DNA-directed RNA polymerase II subunit RPB3
236
DNA-directed RNA polymerases I, II, and III subunit RPABC5
7
9.9
93
0.11
I3LCH3A0A4X1VYD0['transcription by RNA polymerase II']['transcription, DNA-templated']
Uncharacterized protein
245
IGL@ protein
232
2.3
nan
nan
Q6N089Q8N5F4[][]
Igh protein
306
Igh protein
249
7.0
nan
nan
Q99M22Q99M22[][]
Two pore channel protein 2
623
Two pore channel protein 2
623
2.0
40
1.22
Q8NHX9Q8NHX9['calcium-mediated signaling', 'cellular calcium ion homeostasis', 'endocytosis involved in viral entry into host cell', 'endosome to lysosome transport of low-density lipoprotein particle', 'ion transmembrane transport', 'lysosome organization', 'receptor-mediated endocytosis of virus by host cell', 'regulation of autophagy', 'regulation of exocytosis', 'regulation of ion transmembrane transport', 'response to vitamin D', 'smooth muscle contraction', 'sodium ion transmembrane transport']['calcium-mediated signaling', 'cellular calcium ion homeostasis', 'endocytosis involved in viral entry into host cell', 'endosome to lysosome transport of low-density lipoprotein particle', 'ion transmembrane transport', 'lysosome organization', 'receptor-mediated endocytosis of virus by host cell', 'regulation of autophagy', 'regulation of exocytosis', 'regulation of ion transmembrane transport', 'response to vitamin D', 'smooth muscle contraction', 'sodium ion transmembrane transport']
39S ribosomal protein L37, mitochondrial
203
39S ribosomal protein S30, mitochondrial
149
9.5
79
0.13
Q9BZE1Q9NP92['mitochondrial translation', 'translation']['apoptotic process', 'mitochondrial translation']
Transient receptor potential cation channel subfamily V member 3
75
Transient receptor potential cation channel subfamily V member 3
721
9.2
nan
nan
Q8K424Q8K424['calcium ion import across plasma membrane', 'negative regulation of hair cycle', 'positive regulation of calcium ion import', 'response to heat', 'response to temperature stimulus']['calcium ion import across plasma membrane', 'negative regulation of hair cycle', 'positive regulation of calcium ion import', 'response to heat', 'response to temperature stimulus']
Insulin receptor
714
Insulin receptor
712
9.4
27
0.4
P15208P15208['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'animal organ morphogenesis', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'male gonad development', 'male sex determination', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of protein phosphorylation', 'negative regulation of transporter activity', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of hydrogen peroxide metabolic process', 'regulation of transcription, DNA-templated', 'response to nutrient levels', 'response to tumor necrosis factor', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'viral entry into host cell']['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'animal organ morphogenesis', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'male gonad development', 'male sex determination', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of protein phosphorylation', 'negative regulation of transporter activity', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of hydrogen peroxide metabolic process', 'regulation of transcription, DNA-templated', 'response to nutrient levels', 'response to tumor necrosis factor', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'viral entry into host cell']
DNA-directed RNA polymerase III subunit RPC2
924
DNA-directed RNA polymerases I, II, and III subunit RPABC5
10
5.6
104
0.17
Q9NW08P62875['defense response to virus', 'innate immune response', 'positive regulation of innate immune response', 'positive regulation of interferon-beta production', 'transcription, DNA-templated']['regulation of transcription by RNA polymerase I', 'transcription by RNA polymerase I', 'transcription by RNA polymerase II', 'tRNA transcription by RNA polymerase III']
Glycoprotein hormones alpha chain
111
Choriogonadotropin subunit beta 3
113
9.5
62
0.17
P01215P0DN86['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['apoptotic process', 'cell-cell signaling', 'female gamete generation', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'signal transduction']
Transient receptor potential cation channel subfamily V member 3
75
Transient receptor potential cation channel subfamily V member 3
731
9.1
45
0.24
Q8K424Q8K424['calcium ion import across plasma membrane', 'negative regulation of hair cycle', 'positive regulation of calcium ion import', 'response to heat', 'response to temperature stimulus']['calcium ion import across plasma membrane', 'negative regulation of hair cycle', 'positive regulation of calcium ion import', 'response to heat', 'response to temperature stimulus']
Calcium homeostasis modulator protein 6
82
Calcium homeostasis modulator protein 6
198
3.9
nan
nan
Q5R3K3Q5R3K3[][]
Solute carrier family 12 member 6
846
Solute carrier family 12 member 6
846
9.6
92
0.11
Q9UHW9Q9UHW9['ammonium import across plasma membrane', 'angiogenesis', 'cell volume homeostasis', 'cellular hypotonic response', 'cellular hypotonic salinity response', 'cellular response to glucose stimulus', 'chemical synaptic transmission', 'chloride ion homeostasis', 'chloride transmembrane transport', 'ion transport', 'potassium ion homeostasis', 'potassium ion import across plasma membrane']['ammonium import across plasma membrane', 'angiogenesis', 'cell volume homeostasis', 'cellular hypotonic response', 'cellular hypotonic salinity response', 'cellular response to glucose stimulus', 'chemical synaptic transmission', 'chloride ion homeostasis', 'chloride transmembrane transport', 'ion transport', 'potassium ion homeostasis', 'potassium ion import across plasma membrane']
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
222
6.7
96
0.16
W5PUX0W5NRY1['mitochondrial ATP synthesis coupled electron transport'][]
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
175
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
8.5
92
0.13
Q9D6J6Q91YT0['aerobic respiration', 'cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development', 'proton motive force-driven mitochondrial ATP synthesis']['aerobic respiration', 'mitochondrial ATP synthesis coupled electron transport', 'mitochondrial electron transport, NADH to ubiquinone', 'proton motive force-driven mitochondrial ATP synthesis']
DNA-directed RNA polymerase II subunit RPB3
236
DNA-directed RNA polymerases I, II, and III subunit RPABC5
45
9.8
87
0.12
I3LCH3A0A4X1VYD0['transcription by RNA polymerase II']['transcription, DNA-templated']
von Willebrand factor
1126
von Willebrand factor
1097
6.4
65
0.24
P04275P04275['blood coagulation', 'cell adhesion', 'cell-substrate adhesion', 'hemostasis', 'platelet activation', 'positive regulation of intracellular signal transduction', 'response to wounding']['blood coagulation', 'cell adhesion', 'cell-substrate adhesion', 'hemostasis', 'platelet activation', 'positive regulation of intracellular signal transduction', 'response to wounding']
GPI-anchor transamidase
92
GPI transamidase component PIG-T
182
2.0
80
0.61
Q92643Q969N2['attachment of GPI anchor to protein', 'protein localization to cell surface', 'proteolysis']['attachment of GPI anchor to protein', 'neuron apoptotic process', 'neuron differentiation']
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
382
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
64
9.5
87
0.12
W5PUX0W5QB34['mitochondrial ATP synthesis coupled electron transport']['apoptotic mitochondrial changes', 'ATP metabolic process', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'reactive oxygen species metabolic process', 'regulation of mitochondrial membrane potential']
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
137
9.5
91
0.12
W5PUX0W5NRY1['mitochondrial ATP synthesis coupled electron transport'][]
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
176
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
8.0
94
0.13
P04394P25708['cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development']['mitochondrial electron transport, NADH to ubiquinone']
Glial cell line-derived neurotrophic factor
149
Glial cell line-derived neurotrophic factor
178
7.8
52
0.25
P39905P39905['adult locomotory behavior', 'branching involved in ureteric bud morphogenesis', 'commissural neuron axon guidance', 'dorsal spinal cord development', 'embryonic organ development', 'enteric nervous system development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'metanephros development', 'mRNA stabilization', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of neuron apoptotic process', 'nervous system development', 'neural crest cell migration', 'neuron projection development', 'organ induction', 'peripheral nervous system development', 'peristalsis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of dopamine secretion', 'positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis', 'positive regulation of monooxygenase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of ureteric bud formation', 'postganglionic parasympathetic fiber development', 'postsynaptic membrane organization', 'regulation of dopamine uptake involved in synaptic transmission', 'regulation of gene expression', 'regulation of morphogenesis of a branching structure', 'regulation of semaphorin-plexin signaling pathway', 'regulation of stem cell differentiation', 'signal transduction', 'sympathetic nervous system development', 'ureteric bud formation']['adult locomotory behavior', 'branching involved in ureteric bud morphogenesis', 'commissural neuron axon guidance', 'dorsal spinal cord development', 'embryonic organ development', 'enteric nervous system development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'metanephros development', 'mRNA stabilization', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of neuron apoptotic process', 'nervous system development', 'neural crest cell migration', 'neuron projection development', 'organ induction', 'peripheral nervous system development', 'peristalsis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of dopamine secretion', 'positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis', 'positive regulation of monooxygenase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of ureteric bud formation', 'postganglionic parasympathetic fiber development', 'postsynaptic membrane organization', 'regulation of dopamine uptake involved in synaptic transmission', 'regulation of gene expression', 'regulation of morphogenesis of a branching structure', 'regulation of semaphorin-plexin signaling pathway', 'regulation of stem cell differentiation', 'signal transduction', 'sympathetic nervous system development', 'ureteric bud formation']
Serine palmitoyltransferase 1
133
Serine palmitoyltransferase 2
511
9.8
99
0.1
O15269O15270['ceramide biosynthetic process', 'positive regulation of lipophagy', 'regulation of fat cell apoptotic process', 'sphinganine biosynthetic process', 'sphingolipid biosynthetic process', 'sphingolipid metabolic process', 'sphingomyelin biosynthetic process', 'sphingosine biosynthetic process']['adipose tissue development', 'ceramide biosynthetic process', 'positive regulation of lipophagy', 'sphinganine biosynthetic process', 'sphingolipid biosynthetic process', 'sphingomyelin biosynthetic process', 'sphingosine biosynthetic process']
THO complex subunit 2
500
THO complex subunit 3
258
5.3
78
0.24
Q8NI27Q96J01['blastocyst development', 'cell morphogenesis', 'generation of neurons', 'mRNA export from nucleus', 'mRNA processing', 'negative regulation of neuron projection development', 'neuron development', 'poly(A)+ mRNA export from nucleus', 'regulation of gene expression', 'regulation of mRNA export from nucleus', 'RNA splicing', 'stem cell division', 'viral mRNA export from host cell nucleus']['mRNA export from nucleus', 'mRNA processing', 'RNA splicing', 'viral mRNA export from host cell nucleus']
Broad substrate specificity ATP-binding cassette transporter ABCG2
603
Broad substrate specificity ATP-binding cassette transporter ABCG2
608
6.7
63
0.24
Q9UNQ0Q9UNQ0['biotin transport', 'cellular detoxification', 'export across plasma membrane', 'lipid transport', 'organic anion transport', 'renal urate salt excretion', 'riboflavin transport', 'transepithelial transport', 'transmembrane transport', 'transport across blood-brain barrier', 'urate metabolic process', 'xenobiotic transport across blood-brain barrier']['biotin transport', 'cellular detoxification', 'export across plasma membrane', 'lipid transport', 'organic anion transport', 'renal urate salt excretion', 'riboflavin transport', 'transepithelial transport', 'transmembrane transport', 'transport across blood-brain barrier', 'urate metabolic process', 'xenobiotic transport across blood-brain barrier']
Potassium voltage-gated channel subfamily D member 2
236
Dipeptidyl-peptidase 6
43
8.7
58
0.2
Q9NZV8A7E2E4['action potential', 'cellular response to hypoxia', 'chemical synaptic transmission', 'locomotor rhythm', 'neuronal action potential', 'potassium ion transmembrane transport', 'protein homooligomerization', 'regulation of ion transmembrane transport', 'sensory perception of pain']['proteolysis']
39S ribosomal protein L37, mitochondrial
153
39S ribosomal protein S30, mitochondrial
292
8.8
64
0.18
Q9BZE1Q9NP92['mitochondrial translation', 'translation']['apoptotic process', 'mitochondrial translation']
Insulin receptor
674
Insulin receptor
899
2.0
57
0.86
P06213P06213['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell']['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell']
Glutamate receptor ionotropic, delta-1
80
Glutamate receptor ionotropic, delta-1
351
10.0
76
0.13
Q62640Q62640['modulation of chemical synaptic transmission', 'social behavior', 'synaptic transmission, glutamatergic']['modulation of chemical synaptic transmission', 'social behavior', 'synaptic transmission, glutamatergic']
Excitatory amino acid transporter 2
184
Excitatory amino acid transporter 2
184
9.5
80
0.13
P43004P43004['adult behavior', 'cellular response to cocaine', 'cellular response to extracellular stimulus', 'chemical synaptic transmission', 'D-aspartate import across plasma membrane', 'glutathione biosynthetic process', 'ion transport', 'L-aspartate import across plasma membrane', 'L-aspartate transmembrane transport', 'L-glutamate import across plasma membrane', 'L-glutamate transmembrane transport', 'multicellular organism aging', 'multicellular organism growth', 'neurotransmitter reuptake', 'neurotransmitter transport', 'positive regulation of glucose import', 'protein homotrimerization', 'response to amino acid', 'response to wounding', 'response to xenobiotic stimulus', 'telencephalon development', 'transepithelial transport', 'transport across blood-brain barrier', 'visual behavior']['adult behavior', 'cellular response to cocaine', 'cellular response to extracellular stimulus', 'chemical synaptic transmission', 'D-aspartate import across plasma membrane', 'glutathione biosynthetic process', 'ion transport', 'L-aspartate import across plasma membrane', 'L-aspartate transmembrane transport', 'L-glutamate import across plasma membrane', 'L-glutamate transmembrane transport', 'multicellular organism aging', 'multicellular organism growth', 'neurotransmitter reuptake', 'neurotransmitter transport', 'positive regulation of glucose import', 'protein homotrimerization', 'response to amino acid', 'response to wounding', 'response to xenobiotic stimulus', 'telencephalon development', 'transepithelial transport', 'transport across blood-brain barrier', 'visual behavior']
Neutral and basic amino acid transport protein rBAT
114
b(0,+)-type amino acid transporter 1
144
2.0
54
0.91
Q07837P82251['amino acid transport', 'aspartate transmembrane transport', 'basic amino acid transport', 'carbohydrate metabolic process', 'gene expression', 'L-cystine transport', 'L-glutamate transmembrane transport']['L-cystine transport', 'neutral amino acid transport', 'protein-containing complex assembly']
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
186
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
152
7.7
99
0.13
P42026P42028['aerobic respiration', 'electron transport coupled proton transport', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly']['aerobic respiration', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'response to oxidative stress']
Glycoprotein hormones alpha chain
111
Choriogonadotropin subunit beta 3
120
8.2
77
0.16
P01215P0DN86['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['apoptotic process', 'cell-cell signaling', 'female gamete generation', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'signal transduction']
Translation initiation factor eIF-2B subunit beta
198
Translation initiation factor eIF-2B subunit delta
465
3.7
67
0.4
P49770Q9UI10['central nervous system development', 'myelination', 'oligodendrocyte development', 'ovarian follicle development', 'regulation of catalytic activity', 'regulation of translational initiation', 'response to glucose', 'response to heat', 'response to peptide hormone', 'T cell receptor signaling pathway', 'translational initiation']['myelination', 'oligodendrocyte development', 'ovarian follicle development', 'regulation of catalytic activity', 'regulation of translation', 'response to glucose', 'response to heat', 'response to peptide hormone', 'T cell receptor signaling pathway', 'translational initiation']
Immunoglobulin heavy constant alpha 1
192
Polymeric immunoglobulin receptor
486
5.4
62
0.3
P01876P01833['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']['detection of chemical stimulus involved in sensory perception of bitter taste', 'epidermal growth factor receptor signaling pathway', 'Fc receptor signaling pathway', 'immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor', 'receptor clustering', 'retina homeostasis']
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
225
8.1
96
0.13
F1RVN1A0A287BG40['mitochondrial electron transport, NADH to ubiquinone']['cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development']
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
69
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
130
6.4
80
0.2
Q9H1K1Q9H1K1['cellular iron ion homeostasis', 'iron-sulfur cluster assembly', 'negative regulation of iron ion import across plasma membrane', 'positive regulation of aconitate hydratase activity', 'positive regulation of mitochondrial electron transport, NADH to ubiquinone']['cellular iron ion homeostasis', 'iron-sulfur cluster assembly', 'negative regulation of iron ion import across plasma membrane', 'positive regulation of aconitate hydratase activity', 'positive regulation of mitochondrial electron transport, NADH to ubiquinone']
Serine/threonine-protein kinase mTOR
1498
DEP domain-containing mTOR-interacting protein
304
6.9
nan
nan
P42345Q8TB45["'de novo' pyrimidine nucleobase biosynthetic process", 'activation of protein kinase B activity', 'anoikis', 'behavioral response to pain', 'calcineurin-NFAT signaling cascade', 'cardiac muscle cell development', 'cardiac muscle contraction', 'cellular response to amino acid starvation', 'cellular response to amino acid stimulus', 'cellular response to DNA damage stimulus', 'cellular response to hypoxia', 'cellular response to leucine', 'cellular response to leucine starvation', 'cellular response to nutrient levels', 'cellular response to osmotic stress', 'cellular response to starvation', 'cytoskeleton organization', 'energy reserve metabolic process', 'germ cell development', 'heart morphogenesis', 'heart valve morphogenesis', 'inflammatory response', 'lysosome organization', 'macroautophagy', 'multicellular organism growth', 'negative regulation of apoptotic process', 'negative regulation of autophagy', 'negative regulation of calcineurin-NFAT signaling cascade', 'negative regulation of cell size', 'negative regulation of macroautophagy', 'neuronal action potential', 'nucleus localization', 'oligodendrocyte differentiation', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'phosphorylation', 'positive regulation of actin filament polymerization', 'positive regulation of cell growth', 'positive regulation of cytoplasmic translational initiation', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of gene expression', 'positive regulation of glycolytic process', 'positive regulation of keratinocyte migration', 'positive regulation of lamellipodium assembly', 'positive regulation of lipid biosynthetic process', 'positive regulation of myotube differentiation', 'positive regulation of oligodendrocyte differentiation', 'positive regulation of pentose-phosphate shunt', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphoprotein phosphatase activity', 'positive regulation of stress fiber assembly', 'positive regulation of transcription by RNA polymerase III', 'positive regulation of transcription of nucleolar large rRNA by RNA polymerase I', 'positive regulation of translation', 'positive regulation of wound healing, spreading of epidermal cells', 'post-embryonic development', 'protein autophosphorylation', 'protein catabolic process', 'protein phosphorylation', 'regulation of actin cytoskeleton organization', 'regulation of cell growth', 'regulation of cell size', 'regulation of cellular response to heat', 'regulation of circadian rhythm', 'regulation of GTPase activity', 'regulation of locomotor rhythm', 'regulation of macroautophagy', 'regulation of membrane permeability', 'regulation of myelination', 'regulation of osteoclast differentiation', 'regulation of protein kinase B signaling', 'regulation of signal transduction by p53 class mediator', 'response to amino acid', 'response to heat', 'response to insulin', 'response to nutrient', 'response to nutrient levels', 'rhythmic process', 'ruffle organization', 'T-helper 1 cell lineage commitment', 'TOR signaling', 'TORC1 signaling', 'voluntary musculoskeletal movement']['intracellular signal transduction', 'negative regulation of cell size', 'negative regulation of protein kinase activity', 'negative regulation of TOR signaling', 'negative regulation of TORC1 signaling', 'negative regulation of TORC2 signaling', 'regulation of extrinsic apoptotic signaling pathway']
Major prion protein
178
Major prion protein
178
9.8
65
0.16
P04925P04925['activation of protein kinase activity', 'calcium-mediated signaling using intracellular calcium source', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to copper ion', 'cellular response to xenobiotic stimulus', 'learning or memory', 'negative regulation of activated T cell proliferation', 'negative regulation of amyloid precursor protein catabolic process', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of calcineurin-NFAT signaling cascade', 'negative regulation of catalytic activity', 'negative regulation of dendritic spine maintenance', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-17 production', 'negative regulation of interleukin-2 production', 'negative regulation of long-term synaptic potentiation', 'negative regulation of protein phosphorylation', 'negative regulation of T cell receptor signaling pathway', 'neuron projection maintenance', 'nucleobase-containing compound metabolic process', 'positive regulation of cell death', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein targeting to membrane', 'positive regulation of protein tyrosine kinase activity', 'protein destabilization', 'protein homooligomerization', 'regulation of calcium ion import across plasma membrane', 'regulation of glutamate receptor signaling pathway', 'regulation of intracellular calcium activated chloride channel activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of potassium ion transmembrane transport', 'regulation of protein localization', 'response to amyloid-beta', 'response to cadmium ion', 'response to copper ion', 'response to oxidative stress']['activation of protein kinase activity', 'calcium-mediated signaling using intracellular calcium source', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to copper ion', 'cellular response to xenobiotic stimulus', 'learning or memory', 'negative regulation of activated T cell proliferation', 'negative regulation of amyloid precursor protein catabolic process', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of calcineurin-NFAT signaling cascade', 'negative regulation of catalytic activity', 'negative regulation of dendritic spine maintenance', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-17 production', 'negative regulation of interleukin-2 production', 'negative regulation of long-term synaptic potentiation', 'negative regulation of protein phosphorylation', 'negative regulation of T cell receptor signaling pathway', 'neuron projection maintenance', 'nucleobase-containing compound metabolic process', 'positive regulation of cell death', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein targeting to membrane', 'positive regulation of protein tyrosine kinase activity', 'protein destabilization', 'protein homooligomerization', 'regulation of calcium ion import across plasma membrane', 'regulation of glutamate receptor signaling pathway', 'regulation of intracellular calcium activated chloride channel activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of potassium ion transmembrane transport', 'regulation of protein localization', 'response to amyloid-beta', 'response to cadmium ion', 'response to copper ion', 'response to oxidative stress']
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
176
6.6
96
0.16
F1RVN1A0A287BG40['mitochondrial electron transport, NADH to ubiquinone']['cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development']
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
479
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
479
5.9
90
0.19
Q9TV66Q9TV66['cellular response to cAMP', 'potassium ion transmembrane transport', 'regulation of heart rate', 'regulation of ion transmembrane transport']['cellular response to cAMP', 'potassium ion transmembrane transport', 'regulation of heart rate', 'regulation of ion transmembrane transport']
Glutamate receptor 1
75
Glutamate receptor 2
330
7.8
75
0.17
P19490P19491['cellular response to amine stimulus', 'cellular response to amino acid stimulus', 'cellular response to ammonium ion', 'cellular response to dsRNA', 'cellular response to growth factor stimulus', 'cellular response to organic cyclic compound', 'cellular response to peptide hormone stimulus', 'chemical synaptic transmission', 'long-term memory', 'long-term synaptic depression', 'modulation of chemical synaptic transmission', 'neuronal action potential', 'positive regulation of membrane potential', 'positive regulation of synaptic transmission', 'receptor internalization', 'regulation of postsynaptic membrane potential', 'regulation of receptor recycling', 'regulation of synaptic plasticity', 'response to arsenic-containing substance', 'response to cocaine', 'response to electrical stimulus', 'response to estradiol', 'response to fungicide', 'response to lithium ion', 'response to organic cyclic compound', 'response to peptide hormone', 'response to toxic substance', 'response to xenobiotic stimulus', 'spinal cord development', 'synaptic transmission, glutamatergic']['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
95
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
138
9.5
88
0.12
Q9H1K1Q9H1K1['cellular iron ion homeostasis', 'iron-sulfur cluster assembly', 'negative regulation of iron ion import across plasma membrane', 'positive regulation of aconitate hydratase activity', 'positive regulation of mitochondrial electron transport, NADH to ubiquinone']['cellular iron ion homeostasis', 'iron-sulfur cluster assembly', 'negative regulation of iron ion import across plasma membrane', 'positive regulation of aconitate hydratase activity', 'positive regulation of mitochondrial electron transport, NADH to ubiquinone']
Insulin receptor
712
Insulin receptor
712
9.6
21
0.5
P15208P15208['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'animal organ morphogenesis', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'male gonad development', 'male sex determination', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of protein phosphorylation', 'negative regulation of transporter activity', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of hydrogen peroxide metabolic process', 'regulation of transcription, DNA-templated', 'response to nutrient levels', 'response to tumor necrosis factor', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'viral entry into host cell']['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'animal organ morphogenesis', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'male gonad development', 'male sex determination', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of protein phosphorylation', 'negative regulation of transporter activity', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of hydrogen peroxide metabolic process', 'regulation of transcription, DNA-templated', 'response to nutrient levels', 'response to tumor necrosis factor', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'viral entry into host cell']
Inosine-5'-monophosphate dehydrogenase 2
26
Inosine-5'-monophosphate dehydrogenase 2
26
9.8
51
0.2
P12268P12268["'de novo' XMP biosynthetic process", 'cellular response to interleukin-4', 'circadian rhythm', 'GMP biosynthetic process', 'GTP biosynthetic process', 'lymphocyte proliferation', 'retina development in camera-type eye']["'de novo' XMP biosynthetic process", 'cellular response to interleukin-4', 'circadian rhythm', 'GMP biosynthetic process', 'GTP biosynthetic process', 'lymphocyte proliferation', 'retina development in camera-type eye']
ATP synthase lipid-binding protein
99
ATP synthase lipid-binding protein
99
9.6
93
0.11
F1RWF6F1RWF6['proton motive force-driven ATP synthesis']['proton motive force-driven ATP synthesis']
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
135
9.8
92
0.11
F1RVN1A0A287BG40['mitochondrial electron transport, NADH to ubiquinone']['cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development']
Calcium homeostasis modulator protein 4
205
Calcium homeostasis modulator protein 4
82
6.0
38
0.44
Q5JW98Q5JW98[][]
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
151
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
166
8.0
97
0.13
A0A287BDC0I3LK43[][]
Potassium voltage-gated channel subfamily C member 1
78
Potassium voltage-gated channel subfamily C member 1
83
8.5
77
0.15
P48547P48547['cellular response to xenobiotic stimulus', 'cerebellum development', 'globus pallidus development', 'positive regulation of voltage-gated potassium channel activity', 'potassium ion transmembrane transport', 'potassium ion transport', 'protein homooligomerization', 'protein tetramerization', 'response to amine', 'response to auditory stimulus', 'response to fibroblast growth factor', 'response to light intensity', 'response to nerve growth factor', 'response to potassium ion', 'response to toxic substance']['cellular response to xenobiotic stimulus', 'cerebellum development', 'globus pallidus development', 'positive regulation of voltage-gated potassium channel activity', 'potassium ion transmembrane transport', 'potassium ion transport', 'protein homooligomerization', 'protein tetramerization', 'response to amine', 'response to auditory stimulus', 'response to fibroblast growth factor', 'response to light intensity', 'response to nerve growth factor', 'response to potassium ion', 'response to toxic substance']
Neuronal acetylcholine receptor subunit beta-2
262
Neuronal acetylcholine receptor subunit alpha-4
271
8.7
61
0.19
P17787P43681['acetylcholine receptor signaling pathway', 'associative learning', 'B cell activation', 'behavioral response to nicotine', 'calcium ion transport', 'central nervous system projection neuron axonogenesis', 'chemical synaptic transmission', 'cognition', 'ion transmembrane transport', 'ion transport', 'lateral geniculate nucleus development', 'learning', 'locomotory behavior', 'membrane depolarization', 'memory', 'negative regulation of action potential', 'nervous system process', 'optic nerve morphogenesis', 'positive regulation of B cell proliferation', 'positive regulation of dopamine secretion', 'regulation of circadian sleep/wake cycle, REM sleep', 'regulation of dendrite morphogenesis', 'regulation of dopamine metabolic process', 'regulation of dopamine secretion', 'regulation of membrane potential', 'regulation of synapse assembly', 'regulation of synaptic transmission, dopaminergic', 'response to acetylcholine', 'response to cocaine', 'response to ethanol', 'response to hypoxia', 'response to nicotine', 'sensory perception of pain', 'sensory perception of sound', 'signal transduction', 'smooth muscle contraction', 'social behavior', 'synaptic transmission involved in micturition', 'synaptic transmission, cholinergic', 'vestibulocochlear nerve development', 'visual learning', 'visual perception']['action potential', 'B cell activation', 'behavioral response to nicotine', 'calcium ion transport', 'chemical synaptic transmission', 'cognition', 'DNA repair', 'inhibitory postsynaptic potential', 'ion transmembrane transport', 'ion transport', 'membrane depolarization', 'nervous system process', 'regulation of dopamine secretion', 'regulation of membrane potential', 'response to hypoxia', 'response to nicotine', 'response to oxidative stress', 'sensory perception of pain', 'signal transduction', 'synaptic transmission, cholinergic']
Mediator of RNA polymerase II transcription subunit 10
84
Mediator of RNA polymerase II transcription subunit 14
115
5.7
69
0.25
Q9BTT4O60244['positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription elongation from RNA polymerase II promoter', 'positive regulation of transcription initiation from RNA polymerase II promoter', 'RNA polymerase II preinitiation complex assembly']['positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription elongation from RNA polymerase II promoter', 'positive regulation of transcription initiation from RNA polymerase II promoter', 'positive regulation of transcription, DNA-templated', 'regulation of transcription by RNA polymerase II', 'RNA polymerase II preinitiation complex assembly', 'somatic stem cell population maintenance']
Isoform Tau-F of Microtubule-associated protein tau
322
Isoform Tau-F of Microtubule-associated protein tau
322
9.6
70
0.15
P10636-8P10636-8[][]
Glutamate receptor ionotropic, NMDA 1
79
Glutamate receptor ionotropic, NMDA 2A
87
8.9
65
0.17
P35439Q00959['adult locomotory behavior', 'associative learning', 'calcium ion homeostasis', 'calcium ion transmembrane import into cytosol', 'calcium ion transport', 'cation transmembrane transport', 'cation transport', 'cellular calcium ion homeostasis', 'cellular response to manganese ion', 'cerebral cortex development', 'chemical synaptic transmission', 'conditioned taste aversion', 'excitatory postsynaptic potential', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'long-term memory', 'male mating behavior', 'memory', 'negative regulation of neuron apoptotic process', 'neuromuscular process', 'olfactory learning', 'pons maturation', 'positive regulation of apoptotic process', 'positive regulation of calcium ion transport into cytosol', 'positive regulation of cell death', 'positive regulation of cysteine-type endopeptidase activity', 'positive regulation of dendritic spine maintenance', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of reactive oxygen species biosynthetic process', 'positive regulation of Schwann cell migration', 'positive regulation of synaptic transmission, glutamatergic', 'positive regulation of transcription by RNA polymerase II', 'prepulse inhibition', 'propylene metabolic process', 'protein heterotetramerization', 'protein localization to postsynaptic membrane', 'protein-containing complex assembly', 'regulation of axonogenesis', 'regulation of cation transmembrane transport', 'regulation of cell communication', 'regulation of dendrite morphogenesis', 'regulation of long-term neuronal synaptic plasticity', 'regulation of membrane potential', 'regulation of neuron apoptotic process', 'regulation of neuronal synaptic plasticity', 'regulation of respiratory gaseous exchange', 'regulation of synapse assembly', 'regulation of synaptic plasticity', 'response to amine', 'response to amphetamine', 'response to calcium ion', 'response to ethanol', 'response to fungicide', 'response to glycine', 'response to morphine', 'response to organic cyclic compound', 'rhythmic process', 'sensory perception of pain', 'social behavior', 'startle response', 'suckling behavior', 'synaptic transmission, glutamatergic', 'visual learning']['action potential', 'calcium ion transmembrane import into cytosol', 'calcium ion transport', 'cation transmembrane transport', 'cellular response to amino acid stimulus', 'cellular response to dsRNA', 'cellular response to growth factor stimulus', 'cellular response to lipid', 'cellular response to magnesium ion', 'cellular response to manganese ion', 'cellular response to zinc ion', 'cerebral cortex development', 'chemical synaptic transmission', 'dendritic spine organization', 'directional locomotion', 'dopamine metabolic process', 'excitatory postsynaptic potential', 'hippocampus development', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'locomotion', 'long-term synaptic potentiation', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of protein catabolic process', 'neurogenesis', 'positive regulation of apoptotic process', 'positive regulation of cell death', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of synaptic transmission, glutamatergic', 'protein localization to postsynaptic membrane', 'regulation of cation transmembrane transport', 'regulation of long-term neuronal synaptic plasticity', 'regulation of membrane potential', 'regulation of neuronal synaptic plasticity', 'regulation of NMDA receptor activity', 'regulation of postsynaptic membrane potential', 'regulation of synaptic plasticity', 'response to amine', 'response to ammonium ion', 'response to amphetamine', 'response to calcium ion', 'response to carbohydrate', 'response to cocaine', 'response to ethanol', 'response to fungicide', 'response to light stimulus', 'response to manganese ion', 'response to methylmercury', 'response to organic cyclic compound', 'response to other organism', 'response to wounding', 'response to xenobiotic stimulus', 'rhythmic process', 'sensory perception of pain', 'serotonin metabolic process', 'sleep', 'spinal cord development', 'startle response', 'visual learning']
Glutamate receptor ionotropic, delta-1
351
Glutamate receptor ionotropic, delta-1
351
9.1
73
0.15
Q62640Q62640['modulation of chemical synaptic transmission', 'social behavior', 'synaptic transmission, glutamatergic']['modulation of chemical synaptic transmission', 'social behavior', 'synaptic transmission, glutamatergic']
Potassium voltage-gated channel subfamily D member 2
133
Potassium voltage-gated channel subfamily D member 2
111
3.8
68
0.39
Q9NZV8Q9NZV8['action potential', 'cellular response to hypoxia', 'chemical synaptic transmission', 'locomotor rhythm', 'neuronal action potential', 'potassium ion transmembrane transport', 'protein homooligomerization', 'regulation of ion transmembrane transport', 'sensory perception of pain']['action potential', 'cellular response to hypoxia', 'chemical synaptic transmission', 'locomotor rhythm', 'neuronal action potential', 'potassium ion transmembrane transport', 'protein homooligomerization', 'regulation of ion transmembrane transport', 'sensory perception of pain']
ATP synthase F(0) complex subunit C1, mitochondrial
125
ATP synthase F(0) complex subunit C1, mitochondrial
125
9.8
87
0.12
P32876P32876['proton motive force-driven ATP synthesis']['proton motive force-driven ATP synthesis']
Calcium homeostasis modulator protein 4
82
Calcium homeostasis modulator protein 4
209
6.0
40
0.42
Q5JW98Q5JW98[][]
Cysteine desulfurase, mitochondrial
381
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
130
5.9
84
0.2
Q9Y697Q9H1K1['[2Fe-2S] cluster assembly', 'iron incorporation into metallo-sulfur cluster', 'iron-sulfur cluster assembly', 'Mo-molybdopterin cofactor biosynthetic process']['cellular iron ion homeostasis', 'iron-sulfur cluster assembly', 'negative regulation of iron ion import across plasma membrane', 'positive regulation of aconitate hydratase activity', 'positive regulation of mitochondrial electron transport, NADH to ubiquinone']
C-C motif chemokine 20
74
C-C chemokine receptor type 6
36
9.0
66
0.17
P78556P51684['antimicrobial humoral immune response mediated by antimicrobial peptide', 'calcium-mediated signaling using intracellular calcium source', 'cell chemotaxis', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response to bacterium', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of T cell migration', 'signal transduction', 'T cell migration', 'thymocyte migration']['calcium-mediated signaling', 'cell chemotaxis', 'cellular defense response', 'chemotaxis', 'dendritic cell chemotaxis', 'DN2 thymocyte differentiation', 'DN3 thymocyte differentiation', 'humoral immune response', 'immune response', 'isotype switching to IgA isotypes', 'leukocyte migration involved in inflammatory response', 'lymphocyte migration', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of dendritic cell chemotaxis', 'positive regulation of flagellated sperm motility involved in capacitation', 'regulation of T cell migration', 'signal transduction', 'T cell migration', 'thymocyte migration']
P2X purinoceptor 7
363
P2X purinoceptor 7
4
8.5
nan
nan
Q64663Q64663['apoptotic signaling pathway', 'ATP export', 'bleb assembly', 'calcium ion transport', 'cation transport', 'cell death', 'cell morphogenesis', 'cell surface receptor signaling pathway', 'cell volume homeostasis', 'cellular response to dsRNA', 'cellular response to extracellular stimulus', 'cellular response to organic cyclic compound', 'ceramide biosynthetic process', 'collagen metabolic process', 'defense response to Gram-positive bacterium', 'extrinsic apoptotic signaling pathway', 'gene expression', 'homeostasis of number of cells within a tissue', 'inflammatory response', 'membrane depolarization', 'membrane protein ectodomain proteolysis', 'mitochondrion organization', 'NAD transport', 'negative regulation of bone resorption', 'negative regulation of cell volume', 'negative regulation of MAPK cascade', 'neuronal action potential', 'organic cation transport', 'phagolysosome assembly', 'phospholipid transfer to membrane', 'phospholipid translocation', 'plasma membrane organization', 'plasma membrane phospholipid scrambling', 'pore complex assembly', 'positive regulation of apoptotic process', 'positive regulation of bleb assembly', 'positive regulation of bone mineralization', 'positive regulation of calcium ion transport into cytosol', 'positive regulation of catalytic activity', 'positive regulation of cytokine production', 'positive regulation of cytoskeleton organization', 'positive regulation of gamma-aminobutyric acid secretion', 'positive regulation of gene expression', 'positive regulation of glutamate secretion', 'positive regulation of glycolytic process', 'positive regulation of interleukin-1 alpha production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of ion transmembrane transport', 'positive regulation of lymphocyte apoptotic process', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mitochondrial depolarization', 'positive regulation of ossification', 'positive regulation of prostaglandin secretion', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of T cell mediated cytotoxicity', 'programmed cell death', 'protein catabolic process', 'protein phosphorylation', 'protein processing', 'purinergic nucleotide receptor signaling pathway', 'reactive oxygen species metabolic process', 'regulation of presynaptic dense core granule exocytosis', 'regulation of sodium ion transport', 'release of sequestered calcium ion into cytosol', 'response to ATP', 'response to bacterium', 'response to calcium ion', 'response to electrical stimulus', 'response to fluid shear stress', 'response to lipopolysaccharide', 'response to mechanical stimulus', 'response to organic cyclic compound', 'response to organic substance', 'response to xenobiotic stimulus', 'response to zinc ion', 'sensory perception of pain', 'skeletal system morphogenesis', 'synaptic vesicle exocytosis', 'T cell homeostasis', 'T cell proliferation', 'vesicle budding from membrane']['apoptotic signaling pathway', 'ATP export', 'bleb assembly', 'calcium ion transport', 'cation transport', 'cell death', 'cell morphogenesis', 'cell surface receptor signaling pathway', 'cell volume homeostasis', 'cellular response to dsRNA', 'cellular response to extracellular stimulus', 'cellular response to organic cyclic compound', 'ceramide biosynthetic process', 'collagen metabolic process', 'defense response to Gram-positive bacterium', 'extrinsic apoptotic signaling pathway', 'gene expression', 'homeostasis of number of cells within a tissue', 'inflammatory response', 'membrane depolarization', 'membrane protein ectodomain proteolysis', 'mitochondrion organization', 'NAD transport', 'negative regulation of bone resorption', 'negative regulation of cell volume', 'negative regulation of MAPK cascade', 'neuronal action potential', 'organic cation transport', 'phagolysosome assembly', 'phospholipid transfer to membrane', 'phospholipid translocation', 'plasma membrane organization', 'plasma membrane phospholipid scrambling', 'pore complex assembly', 'positive regulation of apoptotic process', 'positive regulation of bleb assembly', 'positive regulation of bone mineralization', 'positive regulation of calcium ion transport into cytosol', 'positive regulation of catalytic activity', 'positive regulation of cytokine production', 'positive regulation of cytoskeleton organization', 'positive regulation of gamma-aminobutyric acid secretion', 'positive regulation of gene expression', 'positive regulation of glutamate secretion', 'positive regulation of glycolytic process', 'positive regulation of interleukin-1 alpha production', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-6 production', 'positive regulation of ion transmembrane transport', 'positive regulation of lymphocyte apoptotic process', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of mitochondrial depolarization', 'positive regulation of ossification', 'positive regulation of prostaglandin secretion', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of T cell mediated cytotoxicity', 'programmed cell death', 'protein catabolic process', 'protein phosphorylation', 'protein processing', 'purinergic nucleotide receptor signaling pathway', 'reactive oxygen species metabolic process', 'regulation of presynaptic dense core granule exocytosis', 'regulation of sodium ion transport', 'release of sequestered calcium ion into cytosol', 'response to ATP', 'response to bacterium', 'response to calcium ion', 'response to electrical stimulus', 'response to fluid shear stress', 'response to lipopolysaccharide', 'response to mechanical stimulus', 'response to organic cyclic compound', 'response to organic substance', 'response to xenobiotic stimulus', 'response to zinc ion', 'sensory perception of pain', 'skeletal system morphogenesis', 'synaptic vesicle exocytosis', 'T cell homeostasis', 'T cell proliferation', 'vesicle budding from membrane']
Calcium homeostasis modulator protein 5
203
Calcium homeostasis modulator protein 5
80
4.8
56
0.37
Q8N5C1Q8N5C1[][]
Immunoglobulin heavy constant alpha 1
182
Immunoglobulin heavy constant alpha 1
122
3.9
nan
nan
P01876P01876['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']
28S ribosomal protein S16, mitochondrial
26
28S ribosomal protein S25, mitochondrial
141
6.6
45
0.34
P82915P82669['mitochondrial translation']['mitochondrial translation']
Broad substrate specificity ATP-binding cassette transporter ABCG2
603
Broad substrate specificity ATP-binding cassette transporter ABCG2
592
9.5
49
0.22
Q9UNQ0Q9UNQ0['biotin transport', 'cellular detoxification', 'export across plasma membrane', 'lipid transport', 'organic anion transport', 'renal urate salt excretion', 'riboflavin transport', 'transepithelial transport', 'transmembrane transport', 'transport across blood-brain barrier', 'urate metabolic process', 'xenobiotic transport across blood-brain barrier']['biotin transport', 'cellular detoxification', 'export across plasma membrane', 'lipid transport', 'organic anion transport', 'renal urate salt excretion', 'riboflavin transport', 'transepithelial transport', 'transmembrane transport', 'transport across blood-brain barrier', 'urate metabolic process', 'xenobiotic transport across blood-brain barrier']
Caveolin-1
133
Caveolin-1
143
5.6
48
0.37
Q03135Q03135['angiogenesis', 'angiotensin-activated signaling pathway involved in heart process', 'apoptotic signaling pathway', 'basement membrane organization', 'calcium ion homeostasis', 'calcium ion transport', 'caveola assembly', 'caveolin-mediated endocytosis', 'cell differentiation', 'cellular calcium ion homeostasis', 'cellular response to exogenous dsRNA', 'cellular response to hyperoxia', 'cellular response to peptide hormone stimulus', 'cellular response to starvation', 'cellular response to transforming growth factor beta stimulus', 'cholesterol homeostasis', 'cholesterol transport', 'cytokine-mediated signaling pathway', 'endothelial cell proliferation', 'establishment of localization in cell', 'fibroblast proliferation', 'glandular epithelial cell differentiation', 'insulin receptor internalization', 'lactation', 'lipid storage', 'maintenance of protein location in cell', 'mammary gland development', 'mammary gland involution', 'MAPK cascade', 'membrane depolarization', 'muscle cell cellular homeostasis', 'negative regulation of anoikis', 'negative regulation of BMP signaling pathway', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cytokine-mediated signaling pathway', 'negative regulation of endothelial cell proliferation', 'negative regulation of epithelial cell differentiation', 'negative regulation of fibroblast proliferation', 'negative regulation of inward rectifier potassium channel activity', 'negative regulation of MAP kinase activity', 'negative regulation of MAPK cascade', 'negative regulation of necroptotic process', 'negative regulation of nitric oxide biosynthetic process', 'negative regulation of nitric-oxide synthase activity', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of peptidyl-tyrosine autophosphorylation', 'negative regulation of pinocytosis', 'negative regulation of potassium ion transmembrane transport', 'negative regulation of protein binding', 'negative regulation of protein tyrosine kinase activity', 'negative regulation of protein ubiquitination', 'negative regulation of receptor signaling pathway via JAK-STAT', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of tyrosine phosphorylation of STAT protein', 'nitric oxide biosynthetic process', 'nitric oxide homeostasis', 'positive regulation of calcium ion transport into cytosol', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of catalytic activity', 'positive regulation of cell adhesion molecule production', 'positive regulation of cell migration', 'positive regulation of cholesterol efflux', 'positive regulation of cold-induced thermogenesis', 'positive regulation of ER-associated ubiquitin-dependent protein catabolic process', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of gap junction assembly', 'positive regulation of gene expression', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein ubiquitination', 'positive regulation of toll-like receptor 3 signaling pathway', 'positive regulation of vasoconstriction', 'post-transcriptional regulation of gene expression', 'protein localization', 'protein localization to basolateral plasma membrane', 'protein localization to plasma membrane raft', 'protein transport', 'receptor internalization', 'receptor internalization involved in canonical Wnt signaling pathway', 'receptor-mediated endocytosis of virus by host cell', 'regulation of blood coagulation', 'regulation of cardiac muscle cell action potential involved in regulation of contraction', 'regulation of cell communication by electrical coupling involved in cardiac conduction', 'regulation of cytosolic calcium ion concentration', 'regulation of entry of bacterium into host cell', 'regulation of fatty acid metabolic process', 'regulation of heart rate by cardiac conduction', 'regulation of membrane repolarization during action potential', 'regulation of peptidase activity', 'regulation of ruffle assembly', 'regulation of smooth muscle contraction', 'regulation of the force of heart contraction by chemical signal', 'regulation of ventricular cardiac muscle cell action potential', 'response to bacterium', 'response to calcium ion', 'response to estrogen', 'response to hypoxia', 'response to ischemia', 'response to progesterone', 'skeletal muscle tissue development', 'T cell costimulation', 'triglyceride metabolic process', 'tyrosine phosphorylation of STAT protein', 'vasculogenesis', 'vasoconstriction', 'vesicle organization']['angiogenesis', 'angiotensin-activated signaling pathway involved in heart process', 'apoptotic signaling pathway', 'basement membrane organization', 'calcium ion homeostasis', 'calcium ion transport', 'caveola assembly', 'caveolin-mediated endocytosis', 'cell differentiation', 'cellular calcium ion homeostasis', 'cellular response to exogenous dsRNA', 'cellular response to hyperoxia', 'cellular response to peptide hormone stimulus', 'cellular response to starvation', 'cellular response to transforming growth factor beta stimulus', 'cholesterol homeostasis', 'cholesterol transport', 'cytokine-mediated signaling pathway', 'endothelial cell proliferation', 'establishment of localization in cell', 'fibroblast proliferation', 'glandular epithelial cell differentiation', 'insulin receptor internalization', 'lactation', 'lipid storage', 'maintenance of protein location in cell', 'mammary gland development', 'mammary gland involution', 'MAPK cascade', 'membrane depolarization', 'muscle cell cellular homeostasis', 'negative regulation of anoikis', 'negative regulation of BMP signaling pathway', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cytokine-mediated signaling pathway', 'negative regulation of endothelial cell proliferation', 'negative regulation of epithelial cell differentiation', 'negative regulation of fibroblast proliferation', 'negative regulation of inward rectifier potassium channel activity', 'negative regulation of MAP kinase activity', 'negative regulation of MAPK cascade', 'negative regulation of necroptotic process', 'negative regulation of nitric oxide biosynthetic process', 'negative regulation of nitric-oxide synthase activity', 'negative regulation of peptidyl-serine phosphorylation', 'negative regulation of peptidyl-tyrosine autophosphorylation', 'negative regulation of pinocytosis', 'negative regulation of potassium ion transmembrane transport', 'negative regulation of protein binding', 'negative regulation of protein tyrosine kinase activity', 'negative regulation of protein ubiquitination', 'negative regulation of receptor signaling pathway via JAK-STAT', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transforming growth factor beta receptor signaling pathway', 'negative regulation of tyrosine phosphorylation of STAT protein', 'nitric oxide biosynthetic process', 'nitric oxide homeostasis', 'positive regulation of calcium ion transport into cytosol', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of catalytic activity', 'positive regulation of cell adhesion molecule production', 'positive regulation of cell migration', 'positive regulation of cholesterol efflux', 'positive regulation of cold-induced thermogenesis', 'positive regulation of ER-associated ubiquitin-dependent protein catabolic process', 'positive regulation of extrinsic apoptotic signaling pathway', 'positive regulation of gap junction assembly', 'positive regulation of gene expression', 'positive regulation of intrinsic apoptotic signaling pathway', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein binding', 'positive regulation of protein ubiquitination', 'positive regulation of toll-like receptor 3 signaling pathway', 'positive regulation of vasoconstriction', 'post-transcriptional regulation of gene expression', 'protein localization', 'protein localization to basolateral plasma membrane', 'protein localization to plasma membrane raft', 'protein transport', 'receptor internalization', 'receptor internalization involved in canonical Wnt signaling pathway', 'receptor-mediated endocytosis of virus by host cell', 'regulation of blood coagulation', 'regulation of cardiac muscle cell action potential involved in regulation of contraction', 'regulation of cell communication by electrical coupling involved in cardiac conduction', 'regulation of cytosolic calcium ion concentration', 'regulation of entry of bacterium into host cell', 'regulation of fatty acid metabolic process', 'regulation of heart rate by cardiac conduction', 'regulation of membrane repolarization during action potential', 'regulation of peptidase activity', 'regulation of ruffle assembly', 'regulation of smooth muscle contraction', 'regulation of the force of heart contraction by chemical signal', 'regulation of ventricular cardiac muscle cell action potential', 'response to bacterium', 'response to calcium ion', 'response to estrogen', 'response to hypoxia', 'response to ischemia', 'response to progesterone', 'skeletal muscle tissue development', 'T cell costimulation', 'triglyceride metabolic process', 'tyrosine phosphorylation of STAT protein', 'vasculogenesis', 'vasoconstriction', 'vesicle organization']
DNA-directed RNA polymerase II subunit RPB1
1430
DNA-directed RNA polymerase subunit beta
1232
9.1
85
0.13
P11414I3LGP4['positive regulation of RNA splicing', 'transcription by RNA polymerase II']['transcription by RNA polymerase II']
Protein unc-79 homolog
541
Protein unc-80 homolog
2958
7.5
nan
nan
E5CYJ9B8XCJ6[]['cation homeostasis']
Ion channel TACAN
12
Ion channel TACAN
68
6.7
45
0.33
Q9BXJ8Q9BXJ8['detection of mechanical stimulus involved in sensory perception of pain', 'fat cell differentiation', 'ion transmembrane transport', 'protein heterooligomerization', 'protein homooligomerization']['detection of mechanical stimulus involved in sensory perception of pain', 'fat cell differentiation', 'ion transmembrane transport', 'protein heterooligomerization', 'protein homooligomerization']
Pre-mRNA-processing-splicing factor 8
719
SNW domain-containing protein 1
250
8.8
67
0.17
Q6P2Q9Q13573['cellular response to lipopolysaccharide', 'cellular response to tumor necrosis factor', 'mRNA processing', 'mRNA splicing, via spliceosome', 'RNA splicing', 'RNA splicing, via transesterification reactions', 'spliceosomal tri-snRNP complex assembly']['cellular response to retinoic acid', 'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator', 'mRNA splicing, via spliceosome', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'positive regulation by host of viral transcription', 'positive regulation of histone H3-K4 methylation', 'positive regulation of mRNA splicing, via spliceosome', 'positive regulation of neurogenesis', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transforming growth factor beta receptor signaling pathway', 'positive regulation of vitamin D receptor signaling pathway', 'regulation of retinoic acid receptor signaling pathway', 'regulation of transcription by RNA polymerase II', 'regulation of vitamin D receptor signaling pathway', 'retinoic acid receptor signaling pathway']
Immunoglobulin heavy constant alpha 1
352
Immunoglobulin J chain
37
2.0
67
0.74
P01876P01591['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'glomerular filtration', 'humoral immune response', 'immune response', 'innate immune response', 'positive regulation of respiratory burst', 'protein-containing complex assembly', 'retina homeostasis']
Mas-related G-protein coupled receptor member X2
180
Cortistatin
93
4.4
52
0.44
Q96LB1O00230['G protein-coupled receptor signaling pathway', 'mast cell activation', 'mast cell degranulation', 'positive regulation of cytokinesis', 'sensory perception of pain', 'sleep']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'chemical synaptic transmission', 'replication fork processing', 'resolution of meiotic recombination intermediates']
DNA-directed RNA polymerase III subunit RPC2
924
DNA-directed RNA polymerases I, II, and III subunit RPABC5
7
8.5
97
0.12
Q9NW08P62875['defense response to virus', 'innate immune response', 'positive regulation of innate immune response', 'positive regulation of interferon-beta production', 'transcription, DNA-templated']['regulation of transcription by RNA polymerase I', 'transcription by RNA polymerase I', 'transcription by RNA polymerase II', 'tRNA transcription by RNA polymerase III']
DNA-directed RNA polymerase I subunit RPA1
968
DNA-directed RNA polymerase I subunit RPA2
689
10.0
79
0.13
O95602Q9H9Y6['negative regulation of protein localization to nucleolus']['embryo implantation', 'neural crest formation', 'nucleologenesis', 'rRNA transcription']
Glycoprotein hormones alpha chain
55
Choriogonadotropin subunit beta 3
58
7.8
77
0.17
P01215P0DN86['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['apoptotic process', 'cell-cell signaling', 'female gamete generation', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'signal transduction']
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
223
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
8.0
87
0.14
Q9D6J6Q91YT0['aerobic respiration', 'cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development', 'proton motive force-driven mitochondrial ATP synthesis']['aerobic respiration', 'mitochondrial ATP synthesis coupled electron transport', 'mitochondrial electron transport, NADH to ubiquinone', 'proton motive force-driven mitochondrial ATP synthesis']
T cell receptor alpha chain constant
94
T cell receptor beta constant 2
131
2.0
39
1.26
P01848A0A0G2JMB4['adaptive immune response', 'alpha-beta T cell activation', 'response to bacterium', 'T cell receptor signaling pathway'][]
Potassium voltage-gated channel subfamily C member 1
83
Potassium voltage-gated channel subfamily C member 1
105
3.7
67
0.4
P48547P48547['cellular response to xenobiotic stimulus', 'cerebellum development', 'globus pallidus development', 'positive regulation of voltage-gated potassium channel activity', 'potassium ion transmembrane transport', 'potassium ion transport', 'protein homooligomerization', 'protein tetramerization', 'response to amine', 'response to auditory stimulus', 'response to fibroblast growth factor', 'response to light intensity', 'response to nerve growth factor', 'response to potassium ion', 'response to toxic substance']['cellular response to xenobiotic stimulus', 'cerebellum development', 'globus pallidus development', 'positive regulation of voltage-gated potassium channel activity', 'potassium ion transmembrane transport', 'potassium ion transport', 'protein homooligomerization', 'protein tetramerization', 'response to amine', 'response to auditory stimulus', 'response to fibroblast growth factor', 'response to light intensity', 'response to nerve growth factor', 'response to potassium ion', 'response to toxic substance']
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
176
9.1
84
0.13
P49821P19404['aerobic respiration', 'mitochondrial ATP synthesis coupled electron transport', 'mitochondrial electron transport, NADH to ubiquinone', 'proton motive force-driven mitochondrial ATP synthesis']['aerobic respiration', 'cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development', 'proton motive force-driven mitochondrial ATP synthesis']
Immunoglobulin heavy constant alpha 2
167
Immunoglobulin heavy constant alpha 2
167
7.8
41
0.31
P01877P01877['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']
Clathrin heavy chain
1569
Clathrin light chain
178
9.1
74
0.15
C0MHR2F1S398['clathrin coat assembly', 'intracellular protein transport', 'mitotic cell cycle', 'receptor-mediated endocytosis']['clathrin-dependent endocytosis', 'intracellular protein transport']
Isoform 1 of Extracellular calcium-sensing receptor
129
Isoform 1 of Extracellular calcium-sensing receptor
131
2.0
51
0.96
P41180-1P41180-1[][]
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
224
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
5.8
97
0.18
Q9D6J6Q91YT0['aerobic respiration', 'cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development', 'proton motive force-driven mitochondrial ATP synthesis']['aerobic respiration', 'mitochondrial ATP synthesis coupled electron transport', 'mitochondrial electron transport, NADH to ubiquinone', 'proton motive force-driven mitochondrial ATP synthesis']
Insulin receptor
551
Insulin receptor
712
7.8
50
0.26
P06213P06213['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell']['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell']
Calcium homeostasis modulator protein 4
210
Calcium homeostasis modulator protein 4
82
9.8
39
0.26
Q5JW98Q5JW98[][]
Immunoglobulin kappa constant
107
Immunoglobulin gamma-1 heavy chain
222
2.0
nan
nan
P01834P0DOX5['adaptive immune response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'retina homeostasis']['adaptive immune response']
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
140
9.8
86
0.12
P49821P19404['aerobic respiration', 'mitochondrial ATP synthesis coupled electron transport', 'mitochondrial electron transport, NADH to ubiquinone', 'proton motive force-driven mitochondrial ATP synthesis']['aerobic respiration', 'cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development', 'proton motive force-driven mitochondrial ATP synthesis']
Extracellular calcium-sensing receptor
131
Extracellular calcium-sensing receptor
129
5.9
50
0.34
P41180P41180['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'anatomical structure morphogenesis', 'apoptotic process', 'bile acid secretion', 'branching morphogenesis of an epithelial tube', 'calcium ion import', 'cellular calcium ion homeostasis', 'cellular response to glucose stimulus', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to hypoxia', 'cellular response to low-density lipoprotein particle stimulus', 'cellular response to peptide', 'cellular response to vitamin D', 'chemosensory behavior', 'chloride transmembrane transport', 'detection of calcium ion', 'fat pad development', 'G protein-coupled receptor signaling pathway', 'JNK cascade', 'ossification', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of ATP-dependent activity', 'positive regulation of calcium ion import', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of insulin secretion', 'positive regulation of positive chemotaxis', 'positive regulation of vasoconstriction', 'regulation of calcium ion transport', 'response to fibroblast growth factor', 'response to ischemia', 'vasodilation']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'anatomical structure morphogenesis', 'apoptotic process', 'bile acid secretion', 'branching morphogenesis of an epithelial tube', 'calcium ion import', 'cellular calcium ion homeostasis', 'cellular response to glucose stimulus', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to hypoxia', 'cellular response to low-density lipoprotein particle stimulus', 'cellular response to peptide', 'cellular response to vitamin D', 'chemosensory behavior', 'chloride transmembrane transport', 'detection of calcium ion', 'fat pad development', 'G protein-coupled receptor signaling pathway', 'JNK cascade', 'ossification', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of ATP-dependent activity', 'positive regulation of calcium ion import', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of insulin secretion', 'positive regulation of positive chemotaxis', 'positive regulation of vasoconstriction', 'regulation of calcium ion transport', 'response to fibroblast growth factor', 'response to ischemia', 'vasodilation']
Diacylglycerol O-acyltransferase 1
92
Diacylglycerol O-acyltransferase 1
92
5.7
46
0.38
O75907O75907['diacylglycerol metabolic process', 'fatty acid homeostasis', 'lipid storage', 'long-chain fatty-acyl-CoA metabolic process', 'monoacylglycerol biosynthetic process', 'triglyceride biosynthetic process', 'triglyceride metabolic process', 'very-low-density lipoprotein particle assembly']['diacylglycerol metabolic process', 'fatty acid homeostasis', 'lipid storage', 'long-chain fatty-acyl-CoA metabolic process', 'monoacylglycerol biosynthetic process', 'triglyceride biosynthetic process', 'triglyceride metabolic process', 'very-low-density lipoprotein particle assembly']
DNA-directed RNA polymerase II subunit RPB2
958
DNA-directed RNA polymerases I, II, and III subunit RPABC5
44
9.6
74
0.14
P30876P62875['transcription by RNA polymerase II']['regulation of transcription by RNA polymerase I', 'transcription by RNA polymerase I', 'transcription by RNA polymerase II', 'tRNA transcription by RNA polymerase III']
39S ribosomal protein L20, mitochondrial
93
39S ribosomal protein L42, mitochondrial
60
9.8
84
0.12
Q9BYC9Q9Y6G3['mitochondrial translation', 'ribosomal large subunit assembly']['mitochondrial translation', 'translation']
N-formyl peptide receptor 2
126
Guanine nucleotide-binding protein G(i) subunit alpha-2
352
5.8
74
0.23
P25090P04899['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'astrocyte activation', 'calcium-mediated signaling', 'cell adhesion', 'cell surface receptor signaling pathway', 'cellular response to amyloid-beta', 'chemotaxis', 'complement receptor mediated signaling pathway', 'defense response to bacterium', 'G protein-coupled receptor signaling pathway', 'immune response-regulating cell surface receptor signaling pathway', 'inflammatory response', 'microglial cell activation', 'negative regulation of inflammatory response', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive chemotaxis', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of innate immune response', 'positive regulation of monocyte chemotaxis', 'positive regulation of phagocytosis', 'positive regulation of protein phosphorylation', 'positive regulation of superoxide anion generation', 'receptor-mediated endocytosis']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell cycle', 'cell division', 'cell population proliferation', 'G protein-coupled acetylcholine receptor signaling pathway', 'G protein-coupled adenosine receptor signaling pathway', 'G protein-coupled receptor signaling pathway', 'gamma-aminobutyric acid signaling pathway', 'negative regulation of adenylate cyclase activity', 'negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'negative regulation of apoptotic signaling pathway', 'negative regulation of calcium ion-dependent exocytosis', 'negative regulation of protein tyrosine phosphatase activity', 'negative regulation of synaptic transmission', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of NAD(P)H oxidase activity', 'positive regulation of neural precursor cell proliferation', 'positive regulation of renal sodium excretion', 'positive regulation of superoxide anion generation', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'regulation of calcium ion transport', 'response to nutrient', 'signal transduction']
Pentraxin-related protein PTX3
317
Pentraxin-related protein PTX3
317
5.4
63
0.29
P26022P26022['extracellular matrix organization', 'inflammatory response', 'innate immune response', 'negative regulation by host of viral exo-alpha-sialidase activity', 'negative regulation by host of viral glycoprotein metabolic process', 'negative regulation by host of viral process', 'negative regulation of exo-alpha-sialidase activity', 'negative regulation of glycoprotein metabolic process', 'negative regulation of viral entry into host cell', 'opsonization', 'ovarian cumulus expansion', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phagocytosis', 'response to yeast']['extracellular matrix organization', 'inflammatory response', 'innate immune response', 'negative regulation by host of viral exo-alpha-sialidase activity', 'negative regulation by host of viral glycoprotein metabolic process', 'negative regulation by host of viral process', 'negative regulation of exo-alpha-sialidase activity', 'negative regulation of glycoprotein metabolic process', 'negative regulation of viral entry into host cell', 'opsonization', 'ovarian cumulus expansion', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phagocytosis', 'response to yeast']
Ion channel TACAN
173
Ion channel TACAN
173
9.0
60
0.18
Q9BXJ8Q9BXJ8['detection of mechanical stimulus involved in sensory perception of pain', 'fat cell differentiation', 'ion transmembrane transport', 'protein heterooligomerization', 'protein homooligomerization']['detection of mechanical stimulus involved in sensory perception of pain', 'fat cell differentiation', 'ion transmembrane transport', 'protein heterooligomerization', 'protein homooligomerization']
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
382
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
75
9.8
89
0.11
P25708P15690['mitochondrial electron transport, NADH to ubiquinone']['apoptotic mitochondrial changes', 'ATP metabolic process', 'cellular respiration', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'reactive oxygen species metabolic process', 'regulation of mitochondrial membrane potential']
Guided entry of tail-anchored proteins factor 1
162
Guided entry of tail-anchored proteins factor CAMLG
275
7.7
64
0.2
O00258P49069['protein insertion into ER membrane', 'protein stabilization', 'tail-anchored membrane protein insertion into ER membrane']['B cell homeostasis', 'defense response', 'epidermal growth factor receptor signaling pathway', 'negative regulation of proteasomal ubiquitin-dependent protein catabolic process', 'negative regulation of protein ubiquitination', 'protein insertion into ER membrane', 'protein stabilization', 'receptor recycling', 'signal transduction', 'tail-anchored membrane protein insertion into ER membrane', 'vesicle-mediated transport']
Glutamate receptor
549
Protein cornichon homolog 2
9
6.7
83
0.18
C9K0Z0O35089[]['localization within membrane', 'negative regulation of anterograde synaptic vesicle transport', 'negative regulation of receptor localization to synapse', 'regulation of AMPA receptor activity', 'regulation of membrane potential', 'regulation of NMDA receptor activity', 'regulation of postsynaptic neurotransmitter receptor activity', 'synaptic transmission, glutamatergic', 'vesicle-mediated transport']
Immunoglobulin heavy constant mu
452
Immunoglobulin heavy constant mu
452
2.0
47
1.05
P01871P01871['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
382
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
75
9.8
84
0.12
Q91YT0Q91VD9['aerobic respiration', 'mitochondrial ATP synthesis coupled electron transport', 'mitochondrial electron transport, NADH to ubiquinone', 'proton motive force-driven mitochondrial ATP synthesis']['aerobic respiration', 'apoptotic mitochondrial changes', 'ATP metabolic process', 'cellular respiration', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'proton motive force-driven mitochondrial ATP synthesis', 'reactive oxygen species metabolic process', 'regulation of mitochondrial membrane potential']
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
186
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
155
9.0
103
0.11
P42026P42028['aerobic respiration', 'electron transport coupled proton transport', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly']['aerobic respiration', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'response to oxidative stress']
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
382
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
75
8.9
88
0.13
W5PUX0W5QB34['mitochondrial ATP synthesis coupled electron transport']['apoptotic mitochondrial changes', 'ATP metabolic process', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'reactive oxygen species metabolic process', 'regulation of mitochondrial membrane potential']
DNA polymerase delta catalytic subunit
1011
Proliferating cell nuclear antigen
27
9.1
63
0.17
P28340P12004['base-excision repair, gap-filling', 'cellular response to UV', 'DNA biosynthetic process', 'DNA repair', 'DNA replication', 'DNA replication proofreading', 'DNA synthesis involved in DNA repair', 'DNA-templated DNA replication', 'error-free translesion synthesis', 'fatty acid homeostasis', 'nucleotide-excision repair, DNA gap filling', 'response to UV']['base-excision repair, gap-filling', 'cellular response to hydrogen peroxide', 'cellular response to UV', 'cellular response to xenobiotic stimulus', 'epithelial cell differentiation', 'estrous cycle', 'heart development', 'leading strand elongation', 'liver regeneration', 'mismatch repair', 'mitotic telomere maintenance via semi-conservative replication', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of deoxyribonuclease activity', 'positive regulation of DNA repair', 'positive regulation of DNA replication', 'positive regulation of DNA-directed DNA polymerase activity', 'replication fork processing', 'response to cadmium ion', 'response to dexamethasone', 'response to estradiol', 'response to L-glutamate', 'translesion synthesis']
Zinc transporter 8
53
Zinc transporter 8
364
6.3
67
0.24
Q8IWU4Q8IWU4['cellular zinc ion homeostasis', 'insulin processing', 'insulin secretion', 'positive regulation of insulin secretion', 'regulation of sequestering of zinc ion', 'regulation of vesicle-mediated transport', 'response to glucose', 'response to interferon-gamma', 'response to interleukin-1', 'response to zinc ion', 'sequestering of zinc ion', 'zinc ion transmembrane transport', 'zinc ion transport']['cellular zinc ion homeostasis', 'insulin processing', 'insulin secretion', 'positive regulation of insulin secretion', 'regulation of sequestering of zinc ion', 'regulation of vesicle-mediated transport', 'response to glucose', 'response to interferon-gamma', 'response to interleukin-1', 'response to zinc ion', 'sequestering of zinc ion', 'zinc ion transmembrane transport', 'zinc ion transport']
Excitatory amino acid transporter 3
158
Excitatory amino acid transporter 3
158
9.6
84
0.12
P43005P43005['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'activation of protein kinase B activity', 'adult behavior', 'behavioral fear response', 'blood vessel morphogenesis', 'brain development', 'cellular response to ammonium ion', 'cellular response to bisphenol A', 'cellular response to cocaine', 'cellular response to mercury ion', 'cellular response to organic cyclic compound', 'cellular zinc ion homeostasis', 'chemical synaptic transmission', 'chloride transmembrane transport', 'conditioned place preference', 'cysteine transport', 'cytokine-mediated signaling pathway', 'D-aspartate import across plasma membrane', 'D-aspartate transport', 'dopamine metabolic process', 'dopamine receptor signaling pathway', 'gene expression', 'glutamate homeostasis', 'glutamate receptor signaling pathway', 'glutathione biosynthetic process', 'grooming behavior', 'heart contraction', 'ion transport', 'L-aspartate import across plasma membrane', 'L-aspartate transmembrane transport', 'L-glutamate import', 'L-glutamate import across plasma membrane', 'L-glutamate transmembrane transport', 'locomotory behavior', 'long-term synaptic potentiation', 'maintenance of blood-brain barrier', 'memory', 'motor behavior', 'motor neuron apoptotic process', 'negative regulation of neuron apoptotic process', 'neurogenesis', 'neuron death in response to oxidative stress', 'neurotransmitter receptor transport to plasma membrane', 'neurotransmitter transport', 'peptidyl-serine phosphorylation', 'positive regulation of heart rate', 'regulation of protein targeting to membrane', 'response to amphetamine', 'response to anesthetic', 'response to axon injury', 'response to decreased oxygen levels', 'response to morphine', 'response to xenobiotic stimulus', 'retina layer formation', 'righting reflex', 'superoxide metabolic process', 'synapse organization', 'transepithelial transport', 'transport across blood-brain barrier', 'zinc ion transmembrane transport']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'activation of protein kinase B activity', 'adult behavior', 'behavioral fear response', 'blood vessel morphogenesis', 'brain development', 'cellular response to ammonium ion', 'cellular response to bisphenol A', 'cellular response to cocaine', 'cellular response to mercury ion', 'cellular response to organic cyclic compound', 'cellular zinc ion homeostasis', 'chemical synaptic transmission', 'chloride transmembrane transport', 'conditioned place preference', 'cysteine transport', 'cytokine-mediated signaling pathway', 'D-aspartate import across plasma membrane', 'D-aspartate transport', 'dopamine metabolic process', 'dopamine receptor signaling pathway', 'gene expression', 'glutamate homeostasis', 'glutamate receptor signaling pathway', 'glutathione biosynthetic process', 'grooming behavior', 'heart contraction', 'ion transport', 'L-aspartate import across plasma membrane', 'L-aspartate transmembrane transport', 'L-glutamate import', 'L-glutamate import across plasma membrane', 'L-glutamate transmembrane transport', 'locomotory behavior', 'long-term synaptic potentiation', 'maintenance of blood-brain barrier', 'memory', 'motor behavior', 'motor neuron apoptotic process', 'negative regulation of neuron apoptotic process', 'neurogenesis', 'neuron death in response to oxidative stress', 'neurotransmitter receptor transport to plasma membrane', 'neurotransmitter transport', 'peptidyl-serine phosphorylation', 'positive regulation of heart rate', 'regulation of protein targeting to membrane', 'response to amphetamine', 'response to anesthetic', 'response to axon injury', 'response to decreased oxygen levels', 'response to morphine', 'response to xenobiotic stimulus', 'retina layer formation', 'righting reflex', 'superoxide metabolic process', 'synapse organization', 'transepithelial transport', 'transport across blood-brain barrier', 'zinc ion transmembrane transport']
Extracellular calcium-sensing receptor
129
Extracellular calcium-sensing receptor
129
9.4
52
0.21
P41180P41180['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'anatomical structure morphogenesis', 'apoptotic process', 'bile acid secretion', 'branching morphogenesis of an epithelial tube', 'calcium ion import', 'cellular calcium ion homeostasis', 'cellular response to glucose stimulus', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to hypoxia', 'cellular response to low-density lipoprotein particle stimulus', 'cellular response to peptide', 'cellular response to vitamin D', 'chemosensory behavior', 'chloride transmembrane transport', 'detection of calcium ion', 'fat pad development', 'G protein-coupled receptor signaling pathway', 'JNK cascade', 'ossification', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of ATP-dependent activity', 'positive regulation of calcium ion import', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of insulin secretion', 'positive regulation of positive chemotaxis', 'positive regulation of vasoconstriction', 'regulation of calcium ion transport', 'response to fibroblast growth factor', 'response to ischemia', 'vasodilation']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'anatomical structure morphogenesis', 'apoptotic process', 'bile acid secretion', 'branching morphogenesis of an epithelial tube', 'calcium ion import', 'cellular calcium ion homeostasis', 'cellular response to glucose stimulus', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to hypoxia', 'cellular response to low-density lipoprotein particle stimulus', 'cellular response to peptide', 'cellular response to vitamin D', 'chemosensory behavior', 'chloride transmembrane transport', 'detection of calcium ion', 'fat pad development', 'G protein-coupled receptor signaling pathway', 'JNK cascade', 'ossification', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of ATP-dependent activity', 'positive regulation of calcium ion import', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of insulin secretion', 'positive regulation of positive chemotaxis', 'positive regulation of vasoconstriction', 'regulation of calcium ion transport', 'response to fibroblast growth factor', 'response to ischemia', 'vasodilation']
Major prion protein
178
Major prion protein
213
3.8
70
0.38
P04925P04925['activation of protein kinase activity', 'calcium-mediated signaling using intracellular calcium source', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to copper ion', 'cellular response to xenobiotic stimulus', 'learning or memory', 'negative regulation of activated T cell proliferation', 'negative regulation of amyloid precursor protein catabolic process', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of calcineurin-NFAT signaling cascade', 'negative regulation of catalytic activity', 'negative regulation of dendritic spine maintenance', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-17 production', 'negative regulation of interleukin-2 production', 'negative regulation of long-term synaptic potentiation', 'negative regulation of protein phosphorylation', 'negative regulation of T cell receptor signaling pathway', 'neuron projection maintenance', 'nucleobase-containing compound metabolic process', 'positive regulation of cell death', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein targeting to membrane', 'positive regulation of protein tyrosine kinase activity', 'protein destabilization', 'protein homooligomerization', 'regulation of calcium ion import across plasma membrane', 'regulation of glutamate receptor signaling pathway', 'regulation of intracellular calcium activated chloride channel activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of potassium ion transmembrane transport', 'regulation of protein localization', 'response to amyloid-beta', 'response to cadmium ion', 'response to copper ion', 'response to oxidative stress']['activation of protein kinase activity', 'calcium-mediated signaling using intracellular calcium source', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to copper ion', 'cellular response to xenobiotic stimulus', 'learning or memory', 'negative regulation of activated T cell proliferation', 'negative regulation of amyloid precursor protein catabolic process', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of calcineurin-NFAT signaling cascade', 'negative regulation of catalytic activity', 'negative regulation of dendritic spine maintenance', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-17 production', 'negative regulation of interleukin-2 production', 'negative regulation of long-term synaptic potentiation', 'negative regulation of protein phosphorylation', 'negative regulation of T cell receptor signaling pathway', 'neuron projection maintenance', 'nucleobase-containing compound metabolic process', 'positive regulation of cell death', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein targeting to membrane', 'positive regulation of protein tyrosine kinase activity', 'protein destabilization', 'protein homooligomerization', 'regulation of calcium ion import across plasma membrane', 'regulation of glutamate receptor signaling pathway', 'regulation of intracellular calcium activated chloride channel activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of potassium ion transmembrane transport', 'regulation of protein localization', 'response to amyloid-beta', 'response to cadmium ion', 'response to copper ion', 'response to oxidative stress']
DNA-directed RNA polymerase I subunit RPA2
535
DNA-directed RNA polymerase I subunit RPA49
81
8.1
75
0.16
Q9H9Y6Q9GZS1['embryo implantation', 'neural crest formation', 'nucleologenesis', 'rRNA transcription']['nucleolar large rRNA transcription by RNA polymerase I', 'RNA polymerase I preinitiation complex assembly', 'transcription elongation from RNA polymerase I promoter']
DNA-directed RNA polymerase I subunit RPA1
67
DNA-directed RNA polymerase I subunit RPA2
1070
9.5
67
0.16
O95602Q9H9Y6['negative regulation of protein localization to nucleolus']['embryo implantation', 'neural crest formation', 'nucleologenesis', 'rRNA transcription']
Potassium channel subfamily K member 1
69
Potassium channel subfamily K member 1
69
2.0
34
1.44
Q9Z2T2Q9Z2T2['potassium ion transmembrane transport', 'regulation of resting membrane potential', 'response to nicotine', 'sodium ion transmembrane transport', 'stabilization of membrane potential']['potassium ion transmembrane transport', 'regulation of resting membrane potential', 'response to nicotine', 'sodium ion transmembrane transport', 'stabilization of membrane potential']
T-cell surface glycoprotein CD3 epsilon chain
119
T-cell surface glycoprotein CD3 gamma chain
104
5.9
55
0.31
P07766P09693['adaptive immune response', 'alpha-beta T cell activation', 'apoptotic signaling pathway', 'calcium-mediated signaling', 'CD4-positive, alpha-beta T cell proliferation', 'cell surface receptor signaling pathway', 'cerebellum development', 'dendrite development', 'G protein-coupled receptor signaling pathway', 'gamma-delta T cell activation', 'negative regulation of gene expression', 'negative regulation of smoothened signaling pathway', 'negative thymic T cell selection', 'peptidyl-tyrosine phosphorylation', 'positive regulation of calcium-mediated signaling', 'positive regulation of CD4-positive, alpha-beta T cell proliferation', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cell-matrix adhesion', 'positive regulation of gene expression', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-2 production', 'positive regulation of interleukin-4 production', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of T cell anergy', 'positive regulation of T cell proliferation', 'positive thymic T cell selection', 'protein-containing complex assembly', 'regulation of apoptotic process', 'signal complex assembly', 'smoothened signaling pathway', 'T cell activation', 'T cell anergy', 'T cell costimulation', 'T cell receptor signaling pathway', 'transmembrane receptor protein tyrosine kinase signaling pathway']['adaptive immune response', 'alpha-beta T cell activation', 'cell surface receptor signaling pathway', 'establishment or maintenance of cell polarity', 'gamma-delta T cell activation', 'positive thymic T cell selection', 'protein transport', 'protein-containing complex assembly', 'regulation of lymphocyte apoptotic process', 'T cell activation', 'T cell receptor signaling pathway']
Insulin receptor
674
Isoform Short of Insulin receptor
887
2.0
62
0.8
P06213P06213-2['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell'][]
Angiotensin-converting enzyme 2
133
Angiotensin-converting enzyme 2
133
8.0
42
0.3
Q9BYF1Q9BYF1['angiotensin maturation', 'angiotensin-mediated drinking behavior', 'blood vessel diameter maintenance', 'maternal process involved in female pregnancy', 'membrane fusion', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of signaling receptor activity', 'negative regulation of smooth muscle cell proliferation', 'positive regulation of amino acid transport', 'positive regulation of cardiac muscle contraction', 'positive regulation of gap junction assembly', 'positive regulation of L-proline import across plasma membrane', 'positive regulation of reactive oxygen species metabolic process', 'receptor-mediated endocytosis of virus by host cell', 'receptor-mediated virion attachment to host cell', 'regulation of cardiac conduction', 'regulation of cell population proliferation', 'regulation of cytokine production', 'regulation of inflammatory response', 'regulation of systemic arterial blood pressure by renin-angiotensin', 'regulation of transmembrane transporter activity', 'regulation of vasoconstriction', 'tryptophan transport', 'viral entry into host cell', 'viral life cycle']['angiotensin maturation', 'angiotensin-mediated drinking behavior', 'blood vessel diameter maintenance', 'maternal process involved in female pregnancy', 'membrane fusion', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of signaling receptor activity', 'negative regulation of smooth muscle cell proliferation', 'positive regulation of amino acid transport', 'positive regulation of cardiac muscle contraction', 'positive regulation of gap junction assembly', 'positive regulation of L-proline import across plasma membrane', 'positive regulation of reactive oxygen species metabolic process', 'receptor-mediated endocytosis of virus by host cell', 'receptor-mediated virion attachment to host cell', 'regulation of cardiac conduction', 'regulation of cell population proliferation', 'regulation of cytokine production', 'regulation of inflammatory response', 'regulation of systemic arterial blood pressure by renin-angiotensin', 'regulation of transmembrane transporter activity', 'regulation of vasoconstriction', 'tryptophan transport', 'viral entry into host cell', 'viral life cycle']
Angiotensin-converting enzyme 2
141
Angiotensin-converting enzyme 2
141
6.7
52
0.29
Q9BYF1Q9BYF1['angiotensin maturation', 'angiotensin-mediated drinking behavior', 'blood vessel diameter maintenance', 'maternal process involved in female pregnancy', 'membrane fusion', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of signaling receptor activity', 'negative regulation of smooth muscle cell proliferation', 'positive regulation of amino acid transport', 'positive regulation of cardiac muscle contraction', 'positive regulation of gap junction assembly', 'positive regulation of L-proline import across plasma membrane', 'positive regulation of reactive oxygen species metabolic process', 'receptor-mediated endocytosis of virus by host cell', 'receptor-mediated virion attachment to host cell', 'regulation of cardiac conduction', 'regulation of cell population proliferation', 'regulation of cytokine production', 'regulation of inflammatory response', 'regulation of systemic arterial blood pressure by renin-angiotensin', 'regulation of transmembrane transporter activity', 'regulation of vasoconstriction', 'tryptophan transport', 'viral entry into host cell', 'viral life cycle']['angiotensin maturation', 'angiotensin-mediated drinking behavior', 'blood vessel diameter maintenance', 'maternal process involved in female pregnancy', 'membrane fusion', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of signaling receptor activity', 'negative regulation of smooth muscle cell proliferation', 'positive regulation of amino acid transport', 'positive regulation of cardiac muscle contraction', 'positive regulation of gap junction assembly', 'positive regulation of L-proline import across plasma membrane', 'positive regulation of reactive oxygen species metabolic process', 'receptor-mediated endocytosis of virus by host cell', 'receptor-mediated virion attachment to host cell', 'regulation of cardiac conduction', 'regulation of cell population proliferation', 'regulation of cytokine production', 'regulation of inflammatory response', 'regulation of systemic arterial blood pressure by renin-angiotensin', 'regulation of transmembrane transporter activity', 'regulation of vasoconstriction', 'tryptophan transport', 'viral entry into host cell', 'viral life cycle']
ATPase GET3
289
ATPase GET3
292
5.9
69
0.24
O43681O43681['post-translational protein targeting to endoplasmic reticulum membrane', 'protein insertion into ER membrane', 'tail-anchored membrane protein insertion into ER membrane']['post-translational protein targeting to endoplasmic reticulum membrane', 'protein insertion into ER membrane', 'tail-anchored membrane protein insertion into ER membrane']
von Willebrand factor
1099
von Willebrand factor
1097
7.8
80
0.16
P04275P04275['blood coagulation', 'cell adhesion', 'cell-substrate adhesion', 'hemostasis', 'platelet activation', 'positive regulation of intracellular signal transduction', 'response to wounding']['blood coagulation', 'cell adhesion', 'cell-substrate adhesion', 'hemostasis', 'platelet activation', 'positive regulation of intracellular signal transduction', 'response to wounding']
Splicing factor 3B subunit 1
677
PHD finger-like domain-containing protein 5A
46
8.8
71
0.16
O75533Q7RTV0['chromatin remodeling', 'mRNA splicing, via spliceosome', 'positive regulation of histone acetylation', 'positive regulation of transcription by RNA polymerase I', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase III', 'RNA splicing', 'RNA splicing, via transesterification reactions', 'spliceosomal complex assembly', 'U2-type prespliceosome assembly']['mRNA splicing, via spliceosome', 'positive regulation of transcription, DNA-templated', 'stem cell differentiation', 'U2-type prespliceosome assembly']
Rapamycin-insensitive companion of mTOR
187
Target of rapamycin complex 2 subunit MAPKAP1
27
9.0
77
0.14
Q6R327Q9BPZ7['actin cytoskeleton reorganization', 'cellular response to nutrient levels', 'cytoskeleton organization', 'embryo development ending in birth or egg hatching', 'negative regulation of apoptotic process', 'peptidyl-serine phosphorylation', 'phosphorylation', 'positive regulation of actin filament polymerization', 'positive regulation of cell growth', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of TOR signaling', 'regulation of actin cytoskeleton organization', 'regulation of establishment of cell polarity', 'regulation of gene expression', 'regulation of GTPase activity', 'regulation of inflammatory response', 'regulation of peptidyl-serine phosphorylation', 'regulation of protein kinase B signaling', 'TORC2 signaling']['cellular response to nutrient levels', 'cytoskeleton organization', 'negative regulation of apoptotic process', 'negative regulation of Ras protein signal transduction', 'phosphorylation', 'positive regulation of cell growth', 'positive regulation of peptidyl-serine phosphorylation', 'regulation of cellular response to oxidative stress', 'substantia nigra development', 'TORC2 signaling']
von Willebrand factor
1091
von Willebrand factor
1097
8.5
78
0.15
P04275P04275['blood coagulation', 'cell adhesion', 'cell-substrate adhesion', 'hemostasis', 'platelet activation', 'positive regulation of intracellular signal transduction', 'response to wounding']['blood coagulation', 'cell adhesion', 'cell-substrate adhesion', 'hemostasis', 'platelet activation', 'positive regulation of intracellular signal transduction', 'response to wounding']
T-cell surface glycoprotein CD3 gamma chain
104
T-cell surface glycoprotein CD3 epsilon chain
122
5.2
54
0.35
P09693P07766['adaptive immune response', 'alpha-beta T cell activation', 'cell surface receptor signaling pathway', 'establishment or maintenance of cell polarity', 'gamma-delta T cell activation', 'positive thymic T cell selection', 'protein transport', 'protein-containing complex assembly', 'regulation of lymphocyte apoptotic process', 'T cell activation', 'T cell receptor signaling pathway']['adaptive immune response', 'alpha-beta T cell activation', 'apoptotic signaling pathway', 'calcium-mediated signaling', 'CD4-positive, alpha-beta T cell proliferation', 'cell surface receptor signaling pathway', 'cerebellum development', 'dendrite development', 'G protein-coupled receptor signaling pathway', 'gamma-delta T cell activation', 'negative regulation of gene expression', 'negative regulation of smoothened signaling pathway', 'negative thymic T cell selection', 'peptidyl-tyrosine phosphorylation', 'positive regulation of calcium-mediated signaling', 'positive regulation of CD4-positive, alpha-beta T cell proliferation', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cell-matrix adhesion', 'positive regulation of gene expression', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-2 production', 'positive regulation of interleukin-4 production', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of T cell anergy', 'positive regulation of T cell proliferation', 'positive thymic T cell selection', 'protein-containing complex assembly', 'regulation of apoptotic process', 'signal complex assembly', 'smoothened signaling pathway', 'T cell activation', 'T cell anergy', 'T cell costimulation', 'T cell receptor signaling pathway', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Pentraxin-related protein PTX3
317
Pentraxin-related protein PTX3
318
2.0
70
0.7
P26022P26022['extracellular matrix organization', 'inflammatory response', 'innate immune response', 'negative regulation by host of viral exo-alpha-sialidase activity', 'negative regulation by host of viral glycoprotein metabolic process', 'negative regulation by host of viral process', 'negative regulation of exo-alpha-sialidase activity', 'negative regulation of glycoprotein metabolic process', 'negative regulation of viral entry into host cell', 'opsonization', 'ovarian cumulus expansion', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phagocytosis', 'response to yeast']['extracellular matrix organization', 'inflammatory response', 'innate immune response', 'negative regulation by host of viral exo-alpha-sialidase activity', 'negative regulation by host of viral glycoprotein metabolic process', 'negative regulation by host of viral process', 'negative regulation of exo-alpha-sialidase activity', 'negative regulation of glycoprotein metabolic process', 'negative regulation of viral entry into host cell', 'opsonization', 'ovarian cumulus expansion', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phagocytosis', 'response to yeast']
Zinc finger CCHC domain-containing protein 8
56
Zinc finger CCHC domain-containing protein 8
56
5.3
50
0.38
Q6NZY4Q6NZY4['mRNA splicing, via spliceosome', 'ncRNA processing', 'snRNA catabolic process']['mRNA splicing, via spliceosome', 'ncRNA processing', 'snRNA catabolic process']
Igh protein
478
Immunoglobulin J chain
90
2.0
81
0.61
Q99M22P01592[]['adaptive immune response', 'antibacterial humoral response', 'glomerular filtration', 'humoral immune response', 'innate immune response', 'positive regulation of respiratory burst', 'protein-containing complex assembly']
WD repeat and HMG-box DNA-binding protein 1
598
WD repeat and HMG-box DNA-binding protein 1
598
7.8
88
0.15
O75717O75717['DNA repair', 'DNA-templated DNA replication', 'mitotic cell cycle']['DNA repair', 'DNA-templated DNA replication', 'mitotic cell cycle']
Glutamate receptor ionotropic, delta-1
80
Glutamate receptor ionotropic, delta-1
80
7.8
66
0.2
Q62640Q62640['modulation of chemical synaptic transmission', 'social behavior', 'synaptic transmission, glutamatergic']['modulation of chemical synaptic transmission', 'social behavior', 'synaptic transmission, glutamatergic']
Splicing factor 3B subunit 1
677
PHD finger-like domain-containing protein 5A
49
8.8
75
0.15
O75533Q7RTV0['chromatin remodeling', 'mRNA splicing, via spliceosome', 'positive regulation of histone acetylation', 'positive regulation of transcription by RNA polymerase I', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase III', 'RNA splicing', 'RNA splicing, via transesterification reactions', 'spliceosomal complex assembly', 'U2-type prespliceosome assembly']['mRNA splicing, via spliceosome', 'positive regulation of transcription, DNA-templated', 'stem cell differentiation', 'U2-type prespliceosome assembly']
Excitatory amino acid transporter 1
186
Excitatory amino acid transporter 1
186
9.6
72
0.14
P43003P43003['auditory behavior', 'cell morphogenesis involved in neuron differentiation', 'cellular response to cocaine', 'cellular sodium ion homeostasis', 'chemical synaptic transmission', 'chloride transmembrane transport', 'cranial nerve development', 'D-aspartate import across plasma membrane', 'gamma-aminobutyric acid biosynthetic process', 'ion transport', 'L-aspartate import across plasma membrane', 'L-glutamate import', 'L-glutamate import across plasma membrane', 'L-glutamate transmembrane transport', 'neuromuscular process controlling balance', 'neurotransmitter transport', 'neurotransmitter uptake', 'positive regulation of synaptic transmission', 'potassium ion transmembrane transport', 'response to antibiotic', 'response to light stimulus', 'response to wounding', 'response to xenobiotic stimulus', 'sensory perception of sound', 'transepithelial transport', 'transport across blood-brain barrier']['auditory behavior', 'cell morphogenesis involved in neuron differentiation', 'cellular response to cocaine', 'cellular sodium ion homeostasis', 'chemical synaptic transmission', 'chloride transmembrane transport', 'cranial nerve development', 'D-aspartate import across plasma membrane', 'gamma-aminobutyric acid biosynthetic process', 'ion transport', 'L-aspartate import across plasma membrane', 'L-glutamate import', 'L-glutamate import across plasma membrane', 'L-glutamate transmembrane transport', 'neuromuscular process controlling balance', 'neurotransmitter transport', 'neurotransmitter uptake', 'positive regulation of synaptic transmission', 'potassium ion transmembrane transport', 'response to antibiotic', 'response to light stimulus', 'response to wounding', 'response to xenobiotic stimulus', 'sensory perception of sound', 'transepithelial transport', 'transport across blood-brain barrier']
Isoform Glur5-2 of Glutamate receptor ionotropic, kainate 1
97
Isoform Glur5-2 of Glutamate receptor ionotropic, kainate 1
348
10.0
69
0.14
P22756-2P22756-2[][]
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
173
9.0
94
0.12
W5PUX0W5NRY1['mitochondrial ATP synthesis coupled electron transport'][]
Major prion protein
179
Major prion protein
214
5.7
72
0.24
P04273P04273['activation of protein kinase activity', 'calcium-mediated signaling using intracellular calcium source', 'cell cycle', 'cellular response to amyloid-beta', 'cellular response to copper ion', 'cellular response to xenobiotic stimulus', 'learning or memory', 'negative regulation of activated T cell proliferation', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of calcineurin-NFAT signaling cascade', 'negative regulation of dendritic spine maintenance', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-17 production', 'negative regulation of interleukin-2 production', 'negative regulation of protein phosphorylation', 'negative regulation of T cell receptor signaling pathway', 'neuron projection maintenance', 'positive regulation of neuron apoptotic process', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein targeting to membrane', 'positive regulation of protein tyrosine kinase activity', 'protein destabilization', 'protein homooligomerization', 'regulation of calcium ion import across plasma membrane', 'regulation of glutamate receptor signaling pathway', 'regulation of intracellular calcium activated chloride channel activity', 'regulation of potassium ion transmembrane transport', 'response to oxidative stress']['activation of protein kinase activity', 'calcium-mediated signaling using intracellular calcium source', 'cell cycle', 'cellular response to amyloid-beta', 'cellular response to copper ion', 'cellular response to xenobiotic stimulus', 'learning or memory', 'negative regulation of activated T cell proliferation', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of calcineurin-NFAT signaling cascade', 'negative regulation of dendritic spine maintenance', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-17 production', 'negative regulation of interleukin-2 production', 'negative regulation of protein phosphorylation', 'negative regulation of T cell receptor signaling pathway', 'neuron projection maintenance', 'positive regulation of neuron apoptotic process', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein targeting to membrane', 'positive regulation of protein tyrosine kinase activity', 'protein destabilization', 'protein homooligomerization', 'regulation of calcium ion import across plasma membrane', 'regulation of glutamate receptor signaling pathway', 'regulation of intracellular calcium activated chloride channel activity', 'regulation of potassium ion transmembrane transport', 'response to oxidative stress']
Interleukin-25
170
Interleukin-25
170
7.8
91
0.14
Q9H293Q9H293['eosinophil differentiation', 'inflammatory response to antigenic stimulus', 'positive regulation of transcription by RNA polymerase II', 'response to fungus', 'response to nematode']['eosinophil differentiation', 'inflammatory response to antigenic stimulus', 'positive regulation of transcription by RNA polymerase II', 'response to fungus', 'response to nematode']
Proteasome subunit beta type-7
247
Proteasome subunit beta type-3
150
9.2
70
0.16
Q99436P49720['proteasomal protein catabolic process', 'proteasome-mediated ubiquitin-dependent protein catabolic process']['proteasomal protein catabolic process', 'proteasome-mediated ubiquitin-dependent protein catabolic process']
Insulin-like growth factor 1 receptor
545
Insulin-like growth factor 1 receptor
545
9.6
nan
nan
Q60751Q60751['adrenal gland development', 'amyloid-beta clearance', 'animal organ morphogenesis', 'axonogenesis', 'brain development', 'cellular response to amyloid-beta', 'cellular response to glucose stimulus', 'cellular response to insulin stimulus', 'cellular response to insulin-like growth factor stimulus', 'cellular response to transforming growth factor beta stimulus', 'cerebellum development', 'dendritic spine maintenance', 'epidermis development', 'establishment of cell polarity', 'estrous cycle', 'exocrine pancreas development', 'glucose homeostasis', 'immune response', 'insulin receptor signaling pathway', 'insulin-like growth factor receptor signaling pathway', 'male sex determination', 'mammary gland development', 'MAPK cascade', 'mitotic nuclear division', 'negative regulation of apoptotic process', 'negative regulation of cholangiocyte apoptotic process', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of hepatocyte apoptotic process', 'negative regulation of MAPK cascade', 'negative regulation of muscle cell apoptotic process', 'negative regulation of protein kinase B signaling', 'neuron projection development', 'peptidyl-tyrosine autophosphorylation', 'phosphatidylinositol-mediated signaling', 'positive regulation of axon regeneration', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cold-induced thermogenesis', 'positive regulation of cytokinesis', 'positive regulation of developmental growth', 'positive regulation of DNA metabolic process', 'positive regulation of kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of osteoblast proliferation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein-containing complex disassembly', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of steroid hormone biosynthetic process', 'positive regulation of transcription, DNA-templated', 'prostate gland epithelium morphogenesis', 'protein autophosphorylation', 'protein kinase B signaling', 'protein phosphorylation', 'regulation of JNK cascade', 'response to ethanol', 'response to L-glutamate', 'transcytosis', 'transmembrane receptor protein tyrosine kinase signaling pathway']['adrenal gland development', 'amyloid-beta clearance', 'animal organ morphogenesis', 'axonogenesis', 'brain development', 'cellular response to amyloid-beta', 'cellular response to glucose stimulus', 'cellular response to insulin stimulus', 'cellular response to insulin-like growth factor stimulus', 'cellular response to transforming growth factor beta stimulus', 'cerebellum development', 'dendritic spine maintenance', 'epidermis development', 'establishment of cell polarity', 'estrous cycle', 'exocrine pancreas development', 'glucose homeostasis', 'immune response', 'insulin receptor signaling pathway', 'insulin-like growth factor receptor signaling pathway', 'male sex determination', 'mammary gland development', 'MAPK cascade', 'mitotic nuclear division', 'negative regulation of apoptotic process', 'negative regulation of cholangiocyte apoptotic process', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of hepatocyte apoptotic process', 'negative regulation of MAPK cascade', 'negative regulation of muscle cell apoptotic process', 'negative regulation of protein kinase B signaling', 'neuron projection development', 'peptidyl-tyrosine autophosphorylation', 'phosphatidylinositol-mediated signaling', 'positive regulation of axon regeneration', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cold-induced thermogenesis', 'positive regulation of cytokinesis', 'positive regulation of developmental growth', 'positive regulation of DNA metabolic process', 'positive regulation of kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of osteoblast proliferation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein-containing complex disassembly', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of steroid hormone biosynthetic process', 'positive regulation of transcription, DNA-templated', 'prostate gland epithelium morphogenesis', 'protein autophosphorylation', 'protein kinase B signaling', 'protein phosphorylation', 'regulation of JNK cascade', 'response to ethanol', 'response to L-glutamate', 'transcytosis', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Prefoldin subunit 3
113
Prefoldin subunit 5
49
8.7
88
0.13
P61758Q99471['microtubule-based process', 'negative regulation of amyloid fibril formation', 'protein folding', 'protein stabilization', 'tubulin complex assembly']['negative regulation of amyloid fibril formation', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of transcription, DNA-templated', 'protein folding', 'protein stabilization', 'regulation of transcription, DNA-templated', 'retina development in camera-type eye']
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
180
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
5.3
100
0.19
P04394P25708['cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development']['mitochondrial electron transport, NADH to ubiquinone']
Transforming growth factor beta-1 proprotein
33
Transforming growth factor beta activator LRRC33
363
2.0
nan
nan
P01137Q86YC3['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['immune response', 'inflammatory response', 'microglia development', 'sequestering of TGFbeta in extracellular matrix', 'superoxide metabolic process', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta1 activation']
Isoform 1 of Extracellular calcium-sensing receptor
129
Isoform 1 of Extracellular calcium-sensing receptor
129
5.3
53
0.35
P41180-1P41180-1[][]
NADH-ubiquinone oxidoreductase chain 6
16
NADH-ubiquinone oxidoreductase chain 4L
32
7.9
96
0.13
A9UIY5P03903[]['aerobic respiration', 'ATP synthesis coupled electron transport', 'proton motive force-driven mitochondrial ATP synthesis']
DNA-directed RNA polymerase II subunit RPB3
236
DNA-directed RNA polymerases I, II, and III subunit RPABC5
10
9.6
81
0.13
P19387P62875['transcription by RNA polymerase II']['regulation of transcription by RNA polymerase I', 'transcription by RNA polymerase I', 'transcription by RNA polymerase II', 'tRNA transcription by RNA polymerase III']
Insulin receptor
710
Insulin receptor
709
8.2
46
0.26
P06213P06213['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell']['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell']
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
140
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
9.9
94
0.11
P04394P25708['cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development']['mitochondrial electron transport, NADH to ubiquinone']
28S ribosomal protein S6, mitochondrial
105
28S ribosomal protein S18c, mitochondrial
101
6.0
54
0.31
P82931P82917['mitochondrial translation']['translation']
Insulin-like growth factor-binding protein 3
240
Insulin-like growth factor I
54
5.4
73
0.25
P17936P05019['apoptotic process', 'MAPK cascade', 'negative regulation of cell population proliferation', 'negative regulation of protein phosphorylation', 'negative regulation of signal transduction', 'negative regulation of smooth muscle cell migration', 'negative regulation of smooth muscle cell proliferation', 'osteoblast differentiation', 'positive regulation of apoptotic process', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of myoblast differentiation', 'protein phosphorylation', 'regulation of cell growth', 'regulation of glucose metabolic process', 'regulation of insulin-like growth factor receptor signaling pathway', 'type B pancreatic cell proliferation']['activation of protein kinase B activity', 'bone mineralization involved in bone maturation', 'cell activation', 'cell population proliferation', 'cellular response to amyloid-beta', 'ERK1 and ERK2 cascade', 'glycolate metabolic process', 'insulin-like growth factor receptor signaling pathway', 'muscle hypertrophy', 'muscle organ development', 'myoblast differentiation', 'myoblast proliferation', 'myotube cell development', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of gene expression', 'negative regulation of interleukin-1 beta production', 'negative regulation of neuroinflammatory response', 'negative regulation of oocyte development', 'negative regulation of release of cytochrome c from mitochondria', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of tumor necrosis factor production', 'negative regulation of vascular associated smooth muscle cell apoptotic process', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol-mediated signaling', 'positive regulation of activated T cell proliferation', 'positive regulation of calcineurin-NFAT signaling cascade', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of DNA binding', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Ras protein signal transduction', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of trophectodermal cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase B signaling', 'protein stabilization', 'proteoglycan biosynthetic process', 'Ras protein signal transduction', 'regulation of gene expression', 'regulation of multicellular organism growth', 'regulation of protein phosphorylation', 'response to heat', 'signal transduction', 'skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration', 'skeletal system development', 'wound healing']
Glial cell line-derived neurotrophic factor
118
Glial cell line-derived neurotrophic factor
178
9.1
55
0.2
P39905P39905['adult locomotory behavior', 'branching involved in ureteric bud morphogenesis', 'commissural neuron axon guidance', 'dorsal spinal cord development', 'embryonic organ development', 'enteric nervous system development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'metanephros development', 'mRNA stabilization', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of neuron apoptotic process', 'nervous system development', 'neural crest cell migration', 'neuron projection development', 'organ induction', 'peripheral nervous system development', 'peristalsis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of dopamine secretion', 'positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis', 'positive regulation of monooxygenase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of ureteric bud formation', 'postganglionic parasympathetic fiber development', 'postsynaptic membrane organization', 'regulation of dopamine uptake involved in synaptic transmission', 'regulation of gene expression', 'regulation of morphogenesis of a branching structure', 'regulation of semaphorin-plexin signaling pathway', 'regulation of stem cell differentiation', 'signal transduction', 'sympathetic nervous system development', 'ureteric bud formation']['adult locomotory behavior', 'branching involved in ureteric bud morphogenesis', 'commissural neuron axon guidance', 'dorsal spinal cord development', 'embryonic organ development', 'enteric nervous system development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'metanephros development', 'mRNA stabilization', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of neuron apoptotic process', 'nervous system development', 'neural crest cell migration', 'neuron projection development', 'organ induction', 'peripheral nervous system development', 'peristalsis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of dopamine secretion', 'positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis', 'positive regulation of monooxygenase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of ureteric bud formation', 'postganglionic parasympathetic fiber development', 'postsynaptic membrane organization', 'regulation of dopamine uptake involved in synaptic transmission', 'regulation of gene expression', 'regulation of morphogenesis of a branching structure', 'regulation of semaphorin-plexin signaling pathway', 'regulation of stem cell differentiation', 'signal transduction', 'sympathetic nervous system development', 'ureteric bud formation']
Neurturin
164
Neurturin
196
8.2
65
0.19
Q99748Q99748['MAPK cascade', 'nerve development', 'nervous system development', 'neural crest cell migration', 'neuron projection development', 'transmembrane receptor protein tyrosine kinase signaling pathway']['MAPK cascade', 'nerve development', 'nervous system development', 'neural crest cell migration', 'neuron projection development', 'transmembrane receptor protein tyrosine kinase signaling pathway']
General transcription factor IIH subunit 3
268
General transcription factor IIH subunit 2
247
6.0
74
0.22
Q13889Q13888['DNA repair', 'nucleotide-excision repair', 'phosphorylation of RNA polymerase II C-terminal domain', 'transcription by RNA polymerase II']['G protein-coupled receptor internalization', 'nucleotide-excision repair', 'positive regulation of DNA helicase activity', 'regulation of transcription by RNA polymerase II', 'response to UV', 'transcription by RNA polymerase II', 'transcription initiation from RNA polymerase II promoter']
ATP synthase F(0) complex subunit C1, mitochondrial
125
ATP synthase F(0) complex subunit C1, mitochondrial
125
9.0
91
0.12
P17605P17605['proton motive force-driven ATP synthesis']['proton motive force-driven ATP synthesis']
Exostosin-like 3
915
Exostosin-like 3
793
2.0
82
0.6
O43909O43909['heparan sulfate proteoglycan biosynthetic process', 'positive regulation of cell growth', 'protein glycosylation']['heparan sulfate proteoglycan biosynthetic process', 'positive regulation of cell growth', 'protein glycosylation']
Potassium voltage-gated channel, Shaw-related subfamily, member 1
83
Potassium voltage-gated channel, Shaw-related subfamily, member 1
105
3.8
68
0.39
Q3KNS8Q3KNS8['protein homooligomerization', 'regulation of ion transmembrane transport']['protein homooligomerization', 'regulation of ion transmembrane transport']
Mucin-2
1092
Mucin-2
1088
8.2
74
0.17
A0A0G2JR65A0A0G2JR65[][]
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
130
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
95
8.2
83
0.15
Q9H1K1Q9H1K1['cellular iron ion homeostasis', 'iron-sulfur cluster assembly', 'negative regulation of iron ion import across plasma membrane', 'positive regulation of aconitate hydratase activity', 'positive regulation of mitochondrial electron transport, NADH to ubiquinone']['cellular iron ion homeostasis', 'iron-sulfur cluster assembly', 'negative regulation of iron ion import across plasma membrane', 'positive regulation of aconitate hydratase activity', 'positive regulation of mitochondrial electron transport, NADH to ubiquinone']
Metabotropic glutamate receptor 2
121
Metabotropic glutamate receptor 2
121
2.0
36
1.37
Q14416Q14416['behavioral response to nicotine', 'chemical synaptic transmission', 'G protein-coupled glutamate receptor signaling pathway', 'gene expression', 'glutamate homeostasis', 'glutamate secretion', 'negative regulation of adenylate cyclase activity', 'regulation of dopamine secretion', 'regulation of glutamate secretion', 'regulation of protein kinase B signaling', 'regulation of response to drug', 'regulation of synaptic transmission, glutamatergic', 'response to cocaine']['behavioral response to nicotine', 'chemical synaptic transmission', 'G protein-coupled glutamate receptor signaling pathway', 'gene expression', 'glutamate homeostasis', 'glutamate secretion', 'negative regulation of adenylate cyclase activity', 'regulation of dopamine secretion', 'regulation of glutamate secretion', 'regulation of protein kinase B signaling', 'regulation of response to drug', 'regulation of synaptic transmission, glutamatergic', 'response to cocaine']
Protein unc-79 homolog
594
Protein unc-80 homolog
2890
7.6
nan
nan
Q9P2D8Q8N2C7[]['cation homeostasis']
Immunoglobulin heavy constant alpha 1
352
Immunoglobulin J chain
91
2.0
76
0.65
P01876P01591['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'glomerular filtration', 'humoral immune response', 'immune response', 'innate immune response', 'positive regulation of respiratory burst', 'protein-containing complex assembly', 'retina homeostasis']
GATOR complex protein NPRL2
286
GATOR complex protein NPRL3
343
9.3
48
0.22
Q8WTW4Q12980['cellular response to amino acid starvation', 'negative regulation of kinase activity', 'negative regulation of TOR signaling', 'negative regulation of TORC1 signaling', 'positive regulation of autophagy']['aorta morphogenesis', 'cardiac muscle tissue development', 'cellular response to amino acid starvation', 'negative regulation of TOR signaling', 'negative regulation of TORC1 signaling', 'positive regulation of autophagy', 'roof of mouth development', 'TORC1 signaling', 'ventricular septum development']
DNA-directed RNA polymerase III subunit RPC1
565
DNA-directed RNA polymerases I and III subunit RPAC2
68
8.0
85
0.15
O14802P0DPB6['defense response to virus', 'innate immune response', 'positive regulation of interferon-beta production', 'transcription, DNA-templated']['transcription, DNA-templated']
28S ribosomal protein S6, mitochondrial
105
28S ribosomal protein S18c, mitochondrial
66
6.7
51
0.29
P82931P82917['mitochondrial translation']['translation']
COP9 signalosome complex subunit 4
378
COP9 signalosome complex subunit 7b
181
9.0
82
0.14
Q9BT78Q9H9Q2['protein deneddylation', 'protein neddylation', 'regulation of protein neddylation']['COP9 signalosome assembly', 'protein deneddylation', 'protein neddylation', 'regulation of protein neddylation']
Germ cell-specific gene 1-like protein
315
Germ cell-specific gene 1-like protein
63
7.0
75
0.19
D3ZK93D3ZK93['regulation of AMPA receptor activity', 'regulation of postsynaptic neurotransmitter receptor activity', 'regulation of postsynaptic neurotransmitter receptor internalization']['regulation of AMPA receptor activity', 'regulation of postsynaptic neurotransmitter receptor activity', 'regulation of postsynaptic neurotransmitter receptor internalization']
Ferritin heavy chain
237
Ferritin heavy chain
31
2.1
39
1.2
P09528P09528['immune response', 'intracellular sequestering of iron ion', 'iron ion transport', 'negative regulation of cell population proliferation', 'negative regulation of fibroblast proliferation', 'negative regulation of necrotic cell death']['immune response', 'intracellular sequestering of iron ion', 'iron ion transport', 'negative regulation of cell population proliferation', 'negative regulation of fibroblast proliferation', 'negative regulation of necrotic cell death']
Voltage-dependent calcium channel gamma-2 subunit
315
Voltage-dependent calcium channel gamma-2 subunit
315
8.5
75
0.16
O88602O88602['eye blink reflex', 'membrane depolarization', 'membrane hyperpolarization', 'nervous system process', 'neuromuscular junction development', 'neurotransmitter receptor internalization', 'neurotransmitter receptor localization to postsynaptic specialization membrane', 'neurotransmitter receptor transport, postsynaptic endosome to lysosome', 'positive regulation of AMPA receptor activity', 'positive regulation of protein localization to basolateral plasma membrane', 'positive regulation of synaptic transmission, glutamatergic', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein targeting to membrane', 'regulation of AMPA receptor activity', 'regulation of membrane potential', 'regulation of postsynaptic membrane neurotransmitter receptor levels', 'regulation of postsynaptic neurotransmitter receptor activity', 'response to calcium ion', 'transmission of nerve impulse']['eye blink reflex', 'membrane depolarization', 'membrane hyperpolarization', 'nervous system process', 'neuromuscular junction development', 'neurotransmitter receptor internalization', 'neurotransmitter receptor localization to postsynaptic specialization membrane', 'neurotransmitter receptor transport, postsynaptic endosome to lysosome', 'positive regulation of AMPA receptor activity', 'positive regulation of protein localization to basolateral plasma membrane', 'positive regulation of synaptic transmission, glutamatergic', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein targeting to membrane', 'regulation of AMPA receptor activity', 'regulation of membrane potential', 'regulation of postsynaptic membrane neurotransmitter receptor levels', 'regulation of postsynaptic neurotransmitter receptor activity', 'response to calcium ion', 'transmission of nerve impulse']
Voltage-dependent calcium channel gamma-2 subunit
315
Voltage-dependent calcium channel gamma-2 subunit
315
6.9
68
0.21
Q9Y698Q9Y698['eye blink reflex', 'membrane depolarization', 'membrane hyperpolarization', 'neuromuscular junction development', 'neurotransmitter receptor internalization', 'neurotransmitter receptor localization to postsynaptic specialization membrane', 'neurotransmitter receptor transport, postsynaptic endosome to lysosome', 'positive regulation of AMPA receptor activity', 'positive regulation of protein localization to basolateral plasma membrane', 'positive regulation of synaptic transmission, glutamatergic', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein targeting to membrane', 'regulation of AMPA receptor activity', 'response to calcium ion', 'transmission of nerve impulse']['eye blink reflex', 'membrane depolarization', 'membrane hyperpolarization', 'neuromuscular junction development', 'neurotransmitter receptor internalization', 'neurotransmitter receptor localization to postsynaptic specialization membrane', 'neurotransmitter receptor transport, postsynaptic endosome to lysosome', 'positive regulation of AMPA receptor activity', 'positive regulation of protein localization to basolateral plasma membrane', 'positive regulation of synaptic transmission, glutamatergic', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein targeting to membrane', 'regulation of AMPA receptor activity', 'response to calcium ion', 'transmission of nerve impulse']
Germ cell-specific gene 1-like protein
315
Germ cell-specific gene 1-like protein
315
7.0
76
0.19
D3Z7H4D3Z7H4['regulation of AMPA receptor activity', 'regulation of postsynaptic neurotransmitter receptor internalization']['regulation of AMPA receptor activity', 'regulation of postsynaptic neurotransmitter receptor internalization']
Germ cell-specific gene 1-like protein
63
Germ cell-specific gene 1-like protein
315
7.8
75
0.17
D3Z7H4D3Z7H4['regulation of AMPA receptor activity', 'regulation of postsynaptic neurotransmitter receptor internalization']['regulation of AMPA receptor activity', 'regulation of postsynaptic neurotransmitter receptor internalization']
Voltage-dependent calcium channel gamma-2 subunit
589
Voltage-dependent calcium channel gamma-2 subunit
589
6.8
69
0.21
Q9Y698Q9Y698['eye blink reflex', 'membrane depolarization', 'membrane hyperpolarization', 'neuromuscular junction development', 'neurotransmitter receptor internalization', 'neurotransmitter receptor localization to postsynaptic specialization membrane', 'neurotransmitter receptor transport, postsynaptic endosome to lysosome', 'positive regulation of AMPA receptor activity', 'positive regulation of protein localization to basolateral plasma membrane', 'positive regulation of synaptic transmission, glutamatergic', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein targeting to membrane', 'regulation of AMPA receptor activity', 'response to calcium ion', 'transmission of nerve impulse']['eye blink reflex', 'membrane depolarization', 'membrane hyperpolarization', 'neuromuscular junction development', 'neurotransmitter receptor internalization', 'neurotransmitter receptor localization to postsynaptic specialization membrane', 'neurotransmitter receptor transport, postsynaptic endosome to lysosome', 'positive regulation of AMPA receptor activity', 'positive regulation of protein localization to basolateral plasma membrane', 'positive regulation of synaptic transmission, glutamatergic', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein targeting to membrane', 'regulation of AMPA receptor activity', 'response to calcium ion', 'transmission of nerve impulse']
Germ cell-specific gene 1-like protein
63
Germ cell-specific gene 1-like protein
63
8.2
67
0.18
D3ZK93D3ZK93['regulation of AMPA receptor activity', 'regulation of postsynaptic neurotransmitter receptor activity', 'regulation of postsynaptic neurotransmitter receptor internalization']['regulation of AMPA receptor activity', 'regulation of postsynaptic neurotransmitter receptor activity', 'regulation of postsynaptic neurotransmitter receptor internalization']
Major prion protein
179
Major prion protein
179
4.9
64
0.32
P04273P04273['activation of protein kinase activity', 'calcium-mediated signaling using intracellular calcium source', 'cell cycle', 'cellular response to amyloid-beta', 'cellular response to copper ion', 'cellular response to xenobiotic stimulus', 'learning or memory', 'negative regulation of activated T cell proliferation', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of calcineurin-NFAT signaling cascade', 'negative regulation of dendritic spine maintenance', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-17 production', 'negative regulation of interleukin-2 production', 'negative regulation of protein phosphorylation', 'negative regulation of T cell receptor signaling pathway', 'neuron projection maintenance', 'positive regulation of neuron apoptotic process', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein targeting to membrane', 'positive regulation of protein tyrosine kinase activity', 'protein destabilization', 'protein homooligomerization', 'regulation of calcium ion import across plasma membrane', 'regulation of glutamate receptor signaling pathway', 'regulation of intracellular calcium activated chloride channel activity', 'regulation of potassium ion transmembrane transport', 'response to oxidative stress']['activation of protein kinase activity', 'calcium-mediated signaling using intracellular calcium source', 'cell cycle', 'cellular response to amyloid-beta', 'cellular response to copper ion', 'cellular response to xenobiotic stimulus', 'learning or memory', 'negative regulation of activated T cell proliferation', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of calcineurin-NFAT signaling cascade', 'negative regulation of dendritic spine maintenance', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-17 production', 'negative regulation of interleukin-2 production', 'negative regulation of protein phosphorylation', 'negative regulation of T cell receptor signaling pathway', 'neuron projection maintenance', 'positive regulation of neuron apoptotic process', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein targeting to membrane', 'positive regulation of protein tyrosine kinase activity', 'protein destabilization', 'protein homooligomerization', 'regulation of calcium ion import across plasma membrane', 'regulation of glutamate receptor signaling pathway', 'regulation of intracellular calcium activated chloride channel activity', 'regulation of potassium ion transmembrane transport', 'response to oxidative stress']
Germ cell-specific gene 1-like protein
315
Germ cell-specific gene 1-like protein
315
7.8
75
0.17
D3ZK93D3ZK93['regulation of AMPA receptor activity', 'regulation of postsynaptic neurotransmitter receptor activity', 'regulation of postsynaptic neurotransmitter receptor internalization']['regulation of AMPA receptor activity', 'regulation of postsynaptic neurotransmitter receptor activity', 'regulation of postsynaptic neurotransmitter receptor internalization']
Calcium homeostasis modulator protein 2
179
Calcium homeostasis modulator protein 2
48
9.7
78
0.13
Q9HA72Q9HA72['positive regulation of apoptotic process']['positive regulation of apoptotic process']
Potassium voltage-gated channel subfamily D member 2
406
Potassium voltage-gated channel subfamily D member 2
406
4.1
80
0.3
Q9NZV8Q9NZV8['action potential', 'cellular response to hypoxia', 'chemical synaptic transmission', 'locomotor rhythm', 'neuronal action potential', 'potassium ion transmembrane transport', 'protein homooligomerization', 'regulation of ion transmembrane transport', 'sensory perception of pain']['action potential', 'cellular response to hypoxia', 'chemical synaptic transmission', 'locomotor rhythm', 'neuronal action potential', 'potassium ion transmembrane transport', 'protein homooligomerization', 'regulation of ion transmembrane transport', 'sensory perception of pain']
Glutamate receptor
350
Glutamate receptor
350
7.8
70
0.18
G3V9I2G3V9I2[][]
Igh protein
478
Immunoglobulin J chain
34
9.8
69
0.15
Q99M22P01592[]['adaptive immune response', 'antibacterial humoral response', 'glomerular filtration', 'humoral immune response', 'innate immune response', 'positive regulation of respiratory burst', 'protein-containing complex assembly']
Germ cell-specific gene 1-like protein
63
Germ cell-specific gene 1-like protein
63
8.4
70
0.17
D3Z7H4D3Z7H4['regulation of AMPA receptor activity', 'regulation of postsynaptic neurotransmitter receptor internalization']['regulation of AMPA receptor activity', 'regulation of postsynaptic neurotransmitter receptor internalization']
DNA-directed RNA polymerase II subunit RPB3
236
DNA-directed RNA polymerases I, II, and III subunit RPABC5
10
9.1
92
0.12
Q3T0Q3Q32P78['transcription by RNA polymerase II']['transcription by RNA polymerase I', 'transcription by RNA polymerase II', 'tRNA transcription by RNA polymerase III']
Glycoprotein hormones alpha chain
55
Thyrotropin subunit beta
51
7.8
70
0.18
P01215P01222['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['anatomical structure morphogenesis', 'cell-cell signaling', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'response to calcium ion', 'response to estrogen', 'response to vitamin A']
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
fMet-Leu-Phe receptor
126
3.7
79
0.34
P63096P21462['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell cycle', 'cell division', 'cellular response to forskolin', 'G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to cell cortex', 'regulation of cAMP-mediated signaling', 'regulation of mitotic spindle organization', 'response to peptide hormone']['adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'chemotaxis', 'complement receptor mediated signaling pathway', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'nitric oxide mediated signal transduction', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of cytosolic calcium ion concentration', 'signal transduction']
Immunoglobulin heavy constant alpha 2
339
Immunoglobulin heavy constant alpha 2
339
2.0
43
1.15
P01877P01877['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
224
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
286
7.9
97
0.13
Q9D6J6Q91YT0['aerobic respiration', 'cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development', 'proton motive force-driven mitochondrial ATP synthesis']['aerobic respiration', 'mitochondrial ATP synthesis coupled electron transport', 'mitochondrial electron transport, NADH to ubiquinone', 'proton motive force-driven mitochondrial ATP synthesis']
T-cell surface glycoprotein CD3 delta chain
96
T-cell surface glycoprotein CD3 epsilon chain
122
4.9
58
0.35
P04234P07766['adaptive immune response', 'alpha-beta T cell activation', 'cell surface receptor signaling pathway', 'positive thymic T cell selection', 'T cell receptor signaling pathway']['adaptive immune response', 'alpha-beta T cell activation', 'apoptotic signaling pathway', 'calcium-mediated signaling', 'CD4-positive, alpha-beta T cell proliferation', 'cell surface receptor signaling pathway', 'cerebellum development', 'dendrite development', 'G protein-coupled receptor signaling pathway', 'gamma-delta T cell activation', 'negative regulation of gene expression', 'negative regulation of smoothened signaling pathway', 'negative thymic T cell selection', 'peptidyl-tyrosine phosphorylation', 'positive regulation of calcium-mediated signaling', 'positive regulation of CD4-positive, alpha-beta T cell proliferation', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cell-matrix adhesion', 'positive regulation of gene expression', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-2 production', 'positive regulation of interleukin-4 production', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of T cell anergy', 'positive regulation of T cell proliferation', 'positive thymic T cell selection', 'protein-containing complex assembly', 'regulation of apoptotic process', 'signal complex assembly', 'smoothened signaling pathway', 'T cell activation', 'T cell anergy', 'T cell costimulation', 'T cell receptor signaling pathway', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
524
Phosphoinositide 3-kinase regulatory subunit 5
123
8.8
64
0.18
P48736O02696['adaptive immune response', 'angiogenesis', 'cell migration', 'cellular response to cAMP', 'dendritic cell chemotaxis', 'endocytosis', 'G protein-coupled receptor signaling pathway', 'hepatocyte apoptotic process', 'immune response', 'inflammatory response', 'innate immune response', 'mast cell degranulation', 'natural killer cell chemotaxis', 'negative regulation of cardiac muscle contraction', 'negative regulation of fibroblast apoptotic process', 'negative regulation of triglyceride catabolic process', 'neutrophil chemotaxis', 'neutrophil extravasation', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol phosphate biosynthetic process', 'phosphatidylinositol-3-phosphate biosynthetic process', 'phosphatidylinositol-mediated signaling', 'phosphorylation', 'platelet aggregation', 'positive regulation of acute inflammatory response', 'positive regulation of cytokine production', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of endothelial cell migration', 'positive regulation of MAP kinase activity', 'positive regulation of protein kinase B signaling', 'positive regulation of Rac protein signal transduction', 'protein phosphorylation', 'regulation of calcium ion transmembrane transport', 'regulation of cell adhesion mediated by integrin', 'respiratory burst involved in defense response', 'secretory granule localization', 'sphingosine-1-phosphate receptor signaling pathway', 'T cell activation', 'T cell chemotaxis', 'T cell proliferation']['G protein-coupled receptor signaling pathway', 'phosphatidylinositol 3-kinase signaling', 'positive regulation of MAP kinase activity', 'positive regulation of protein kinase B signaling']
DNA-directed RNA polymerase II subunit RPB3
236
DNA-directed RNA polymerases I, II, and III subunit RPABC5
10
7.9
97
0.13
I3LCH3A0A4X1VYD0['transcription by RNA polymerase II']['transcription, DNA-templated']
Voltage-dependent calcium channel gamma-2 subunit
589
Voltage-dependent calcium channel gamma-2 subunit
589
7.6
70
0.19
O88602O88602['eye blink reflex', 'membrane depolarization', 'membrane hyperpolarization', 'nervous system process', 'neuromuscular junction development', 'neurotransmitter receptor internalization', 'neurotransmitter receptor localization to postsynaptic specialization membrane', 'neurotransmitter receptor transport, postsynaptic endosome to lysosome', 'positive regulation of AMPA receptor activity', 'positive regulation of protein localization to basolateral plasma membrane', 'positive regulation of synaptic transmission, glutamatergic', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein targeting to membrane', 'regulation of AMPA receptor activity', 'regulation of membrane potential', 'regulation of postsynaptic membrane neurotransmitter receptor levels', 'regulation of postsynaptic neurotransmitter receptor activity', 'response to calcium ion', 'transmission of nerve impulse']['eye blink reflex', 'membrane depolarization', 'membrane hyperpolarization', 'nervous system process', 'neuromuscular junction development', 'neurotransmitter receptor internalization', 'neurotransmitter receptor localization to postsynaptic specialization membrane', 'neurotransmitter receptor transport, postsynaptic endosome to lysosome', 'positive regulation of AMPA receptor activity', 'positive regulation of protein localization to basolateral plasma membrane', 'positive regulation of synaptic transmission, glutamatergic', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein targeting to membrane', 'regulation of AMPA receptor activity', 'regulation of membrane potential', 'regulation of postsynaptic membrane neurotransmitter receptor levels', 'regulation of postsynaptic neurotransmitter receptor activity', 'response to calcium ion', 'transmission of nerve impulse']
DNA-directed RNA polymerase III subunit RPC2
919
DNA-directed RNA polymerases I, II, and III subunit RPABC5
44
9.8
82
0.12
Q9NW08P62875['defense response to virus', 'innate immune response', 'positive regulation of innate immune response', 'positive regulation of interferon-beta production', 'transcription, DNA-templated']['regulation of transcription by RNA polymerase I', 'transcription by RNA polymerase I', 'transcription by RNA polymerase II', 'tRNA transcription by RNA polymerase III']
Major prion protein
213
Major prion protein
213
4.9
83
0.25
P04925P04925['activation of protein kinase activity', 'calcium-mediated signaling using intracellular calcium source', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to copper ion', 'cellular response to xenobiotic stimulus', 'learning or memory', 'negative regulation of activated T cell proliferation', 'negative regulation of amyloid precursor protein catabolic process', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of calcineurin-NFAT signaling cascade', 'negative regulation of catalytic activity', 'negative regulation of dendritic spine maintenance', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-17 production', 'negative regulation of interleukin-2 production', 'negative regulation of long-term synaptic potentiation', 'negative regulation of protein phosphorylation', 'negative regulation of T cell receptor signaling pathway', 'neuron projection maintenance', 'nucleobase-containing compound metabolic process', 'positive regulation of cell death', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein targeting to membrane', 'positive regulation of protein tyrosine kinase activity', 'protein destabilization', 'protein homooligomerization', 'regulation of calcium ion import across plasma membrane', 'regulation of glutamate receptor signaling pathway', 'regulation of intracellular calcium activated chloride channel activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of potassium ion transmembrane transport', 'regulation of protein localization', 'response to amyloid-beta', 'response to cadmium ion', 'response to copper ion', 'response to oxidative stress']['activation of protein kinase activity', 'calcium-mediated signaling using intracellular calcium source', 'cellular copper ion homeostasis', 'cellular response to amyloid-beta', 'cellular response to copper ion', 'cellular response to xenobiotic stimulus', 'learning or memory', 'negative regulation of activated T cell proliferation', 'negative regulation of amyloid precursor protein catabolic process', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of calcineurin-NFAT signaling cascade', 'negative regulation of catalytic activity', 'negative regulation of dendritic spine maintenance', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-17 production', 'negative regulation of interleukin-2 production', 'negative regulation of long-term synaptic potentiation', 'negative regulation of protein phosphorylation', 'negative regulation of T cell receptor signaling pathway', 'neuron projection maintenance', 'nucleobase-containing compound metabolic process', 'positive regulation of cell death', 'positive regulation of neuron apoptotic process', 'positive regulation of neuron death', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein targeting to membrane', 'positive regulation of protein tyrosine kinase activity', 'protein destabilization', 'protein homooligomerization', 'regulation of calcium ion import across plasma membrane', 'regulation of glutamate receptor signaling pathway', 'regulation of intracellular calcium activated chloride channel activity', 'regulation of peptidyl-tyrosine phosphorylation', 'regulation of potassium ion transmembrane transport', 'regulation of protein localization', 'response to amyloid-beta', 'response to cadmium ion', 'response to copper ion', 'response to oxidative stress']
DNA-directed RNA polymerase III subunit RPC2
527
DNA-directed RNA polymerase III subunit RPC4
354
8.9
83
0.14
Q9NW08P05423['defense response to virus', 'innate immune response', 'positive regulation of innate immune response', 'positive regulation of interferon-beta production', 'transcription, DNA-templated']['defense response to virus', 'innate immune response', 'positive regulation of innate immune response', 'positive regulation of interferon-beta production', 'transcription by RNA polymerase III']
Teneurin-4
2585
Teneurin-4
2585
2.0
42
1.18
Q6N022Q6N022['cardiac cell fate specification', 'cardiac muscle cell proliferation', 'central nervous system myelin formation', 'gastrulation with mouth forming second', 'heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules', 'neuron development', 'positive regulation of gastrulation', 'positive regulation of myelination', 'positive regulation of oligodendrocyte differentiation', 'regulation of myelination', 'signal transduction']['cardiac cell fate specification', 'cardiac muscle cell proliferation', 'central nervous system myelin formation', 'gastrulation with mouth forming second', 'heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules', 'neuron development', 'positive regulation of gastrulation', 'positive regulation of myelination', 'positive regulation of oligodendrocyte differentiation', 'regulation of myelination', 'signal transduction']
Glycoprotein hormones alpha chain
83
Thyrotropin subunit beta
51
8.8
81
0.14
P01215P01222['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['anatomical structure morphogenesis', 'cell-cell signaling', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'response to calcium ion', 'response to estrogen', 'response to vitamin A']
Glutamate receptor ionotropic, NMDA 2B
321
Glutamate receptor ionotropic, NMDA 1
831
6.2
48
0.34
Q00960P35439['action potential', 'associative learning', 'behavioral fear response', 'behavioral response to pain', 'calcium ion transmembrane import into cytosol', 'calcium ion transport', 'cation transmembrane transport', 'cation transport', 'cellular response to amino acid stimulus', 'cellular response to corticosterone stimulus', 'cellular response to curcumin', 'cellular response to dsRNA', 'cellular response to forskolin', 'cellular response to growth factor stimulus', 'cellular response to lipid', 'cellular response to magnesium starvation', 'cellular response to manganese ion', 'cellular response to organic cyclic compound', 'cerebral cortex development', 'chemical synaptic transmission', 'detection of mechanical stimulus involved in sensory perception of pain', 'excitatory postsynaptic potential', 'fear response', 'hippocampus development', 'in utero embryonic development', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'long-term memory', 'long-term synaptic potentiation', 'memory', 'multicellular organismal response to stress', 'negative regulation of dendritic spine maintenance', 'NMDA selective glutamate receptor signaling pathway', 'positive regulation of cell death', 'positive regulation of cysteine-type endopeptidase activity', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of glutamate secretion', 'positive regulation of neuron death', 'positive regulation of synaptic transmission', 'positive regulation of synaptic transmission, glutamatergic', 'protein heterotetramerization', 'receptor clustering', 'regulation of cation transmembrane transport', 'regulation of long-term neuronal synaptic plasticity', 'regulation of MAPK cascade', 'regulation of neuronal synaptic plasticity', 'regulation of postsynaptic cytosolic calcium ion concentration', 'regulation of postsynaptic membrane potential', 'regulation of protein kinase A signaling', 'regulation of synaptic plasticity', 'response to amine', 'response to amphetamine', 'response to calcium ion', 'response to carbohydrate', 'response to cocaine', 'response to cytokine', 'response to electrical stimulus', 'response to ethanol', 'response to fungicide', 'response to growth hormone', 'response to hypoxia', 'response to magnesium ion', 'response to manganese ion', 'response to mechanical stimulus', 'response to methylmercury', 'response to organic cyclic compound', 'response to organonitrogen compound', 'response to other organism', 'response to toxic substance', 'rhythmic process', 'sensitization', 'sensory organ development', 'startle response', 'suckling behavior']['adult locomotory behavior', 'associative learning', 'calcium ion homeostasis', 'calcium ion transmembrane import into cytosol', 'calcium ion transport', 'cation transmembrane transport', 'cation transport', 'cellular calcium ion homeostasis', 'cellular response to manganese ion', 'cerebral cortex development', 'chemical synaptic transmission', 'conditioned taste aversion', 'excitatory postsynaptic potential', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'long-term memory', 'male mating behavior', 'memory', 'negative regulation of neuron apoptotic process', 'neuromuscular process', 'olfactory learning', 'pons maturation', 'positive regulation of apoptotic process', 'positive regulation of calcium ion transport into cytosol', 'positive regulation of cell death', 'positive regulation of cysteine-type endopeptidase activity', 'positive regulation of dendritic spine maintenance', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of reactive oxygen species biosynthetic process', 'positive regulation of Schwann cell migration', 'positive regulation of synaptic transmission, glutamatergic', 'positive regulation of transcription by RNA polymerase II', 'prepulse inhibition', 'propylene metabolic process', 'protein heterotetramerization', 'protein localization to postsynaptic membrane', 'protein-containing complex assembly', 'regulation of axonogenesis', 'regulation of cation transmembrane transport', 'regulation of cell communication', 'regulation of dendrite morphogenesis', 'regulation of long-term neuronal synaptic plasticity', 'regulation of membrane potential', 'regulation of neuron apoptotic process', 'regulation of neuronal synaptic plasticity', 'regulation of respiratory gaseous exchange', 'regulation of synapse assembly', 'regulation of synaptic plasticity', 'response to amine', 'response to amphetamine', 'response to calcium ion', 'response to ethanol', 'response to fungicide', 'response to glycine', 'response to morphine', 'response to organic cyclic compound', 'rhythmic process', 'sensory perception of pain', 'social behavior', 'startle response', 'suckling behavior', 'synaptic transmission, glutamatergic', 'visual learning']
Calcium homeostasis modulator protein 2
179
Calcium homeostasis modulator protein 2
130
8.0
79
0.16
Q9HA72Q9HA72['positive regulation of apoptotic process']['positive regulation of apoptotic process']
Calcium homeostasis modulator protein 2
179
Calcium homeostasis modulator protein 2
46
8.4
83
0.14
Q9HA72Q9HA72['positive regulation of apoptotic process']['positive regulation of apoptotic process']
Glutamate receptor ionotropic, NMDA 2A
745
Glutamate receptor ionotropic, NMDA 1
798
2.0
62
0.79
Q12879Q05586['activation of cysteine-type endopeptidase activity', 'brain development', 'calcium ion transmembrane import into cytosol', 'cation transmembrane transport', 'chemical synaptic transmission', 'directional locomotion', 'dopamine metabolic process', 'excitatory chemical synaptic transmission', 'excitatory postsynaptic potential', 'glutamate receptor signaling pathway', 'ionotropic glutamate receptor signaling pathway', 'learning or memory', 'long-term synaptic potentiation', 'memory', 'negative regulation of protein catabolic process', 'neurogenesis', 'positive regulation of apoptotic process', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of synaptic transmission, glutamatergic', 'protein catabolic process', 'protein localization to postsynaptic membrane', 'regulation of cation transmembrane transport', 'regulation of neuronal synaptic plasticity', 'regulation of synaptic plasticity', 'response to amphetamine', 'response to ethanol', 'response to wounding', 'response to xenobiotic stimulus', 'sensory perception of pain', 'serotonin metabolic process', 'sleep', 'startle response', 'visual learning']['brain development', 'calcium ion homeostasis', 'calcium ion transmembrane import into cytosol', 'cation transmembrane transport', 'cation transport', 'chemical synaptic transmission', 'excitatory chemical synaptic transmission', 'excitatory postsynaptic potential', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of calcium ion transport into cytosol', 'positive regulation of cysteine-type endopeptidase activity', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of reactive oxygen species biosynthetic process', 'positive regulation of synaptic transmission, glutamatergic', 'positive regulation of transcription by RNA polymerase II', 'propylene metabolic process', 'protein heterotetramerization', 'regulation of cation transmembrane transport', 'regulation of membrane potential', 'regulation of neuronal synaptic plasticity', 'regulation of synaptic plasticity', 'response to ethanol', 'response to glycine', 'visual learning']
Calcium homeostasis modulator protein 2
48
Calcium homeostasis modulator protein 2
180
9.4
77
0.14
Q9HA72Q9HA72['positive regulation of apoptotic process']['positive regulation of apoptotic process']
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
140
8.2
92
0.13
F1RVN1A0A287BG40['mitochondrial electron transport, NADH to ubiquinone']['cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development']
Calcium homeostasis modulator protein 2
46
Calcium homeostasis modulator protein 2
180
8.6
79
0.15
Q9HA72Q9HA72['positive regulation of apoptotic process']['positive regulation of apoptotic process']
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
286
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
225
7.7
94
0.14
F1RVN1A0A287BG40['mitochondrial electron transport, NADH to ubiquinone']['cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development']
Neuronal acetylcholine receptor subunit alpha-4
271
Neuronal acetylcholine receptor subunit alpha-4
271
9.8
63
0.16
P43681P43681['action potential', 'B cell activation', 'behavioral response to nicotine', 'calcium ion transport', 'chemical synaptic transmission', 'cognition', 'DNA repair', 'inhibitory postsynaptic potential', 'ion transmembrane transport', 'ion transport', 'membrane depolarization', 'nervous system process', 'regulation of dopamine secretion', 'regulation of membrane potential', 'response to hypoxia', 'response to nicotine', 'response to oxidative stress', 'sensory perception of pain', 'signal transduction', 'synaptic transmission, cholinergic']['action potential', 'B cell activation', 'behavioral response to nicotine', 'calcium ion transport', 'chemical synaptic transmission', 'cognition', 'DNA repair', 'inhibitory postsynaptic potential', 'ion transmembrane transport', 'ion transport', 'membrane depolarization', 'nervous system process', 'regulation of dopamine secretion', 'regulation of membrane potential', 'response to hypoxia', 'response to nicotine', 'response to oxidative stress', 'sensory perception of pain', 'signal transduction', 'synaptic transmission, cholinergic']
Immunoglobulin J chain
35
Immunoglobulin heavy constant alpha 2
339
9.8
68
0.15
P01591P01877['adaptive immune response', 'antibacterial humoral response', 'glomerular filtration', 'humoral immune response', 'immune response', 'innate immune response', 'positive regulation of respiratory burst', 'protein-containing complex assembly', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
153
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
183
8.1
98
0.13
O00217O75251['aerobic respiration', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'proton motive force-driven mitochondrial ATP synthesis', 'response to oxidative stress']['aerobic respiration', 'electron transport coupled proton transport', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'proton motive force-driven mitochondrial ATP synthesis']
28S ribosomal protein S16, mitochondrial
26
28S ribosomal protein S25, mitochondrial
149
3.7
50
0.54
P82915P82669['mitochondrial translation']['mitochondrial translation']
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
Neuropeptide Y receptor type 2
151
3.7
71
0.38
P63096P49146['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell cycle', 'cell division', 'cellular response to forskolin', 'G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to cell cortex', 'regulation of cAMP-mediated signaling', 'regulation of mitotic spindle organization', 'response to peptide hormone']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'cardiac left ventricle morphogenesis', 'G protein-coupled receptor signaling pathway', 'locomotory behavior', 'outflow tract morphogenesis']
T-cell surface glycoprotein CD3 delta chain
96
T-cell surface glycoprotein CD3 epsilon chain
119
5.1
74
0.26
P04234P07766['adaptive immune response', 'alpha-beta T cell activation', 'cell surface receptor signaling pathway', 'positive thymic T cell selection', 'T cell receptor signaling pathway']['adaptive immune response', 'alpha-beta T cell activation', 'apoptotic signaling pathway', 'calcium-mediated signaling', 'CD4-positive, alpha-beta T cell proliferation', 'cell surface receptor signaling pathway', 'cerebellum development', 'dendrite development', 'G protein-coupled receptor signaling pathway', 'gamma-delta T cell activation', 'negative regulation of gene expression', 'negative regulation of smoothened signaling pathway', 'negative thymic T cell selection', 'peptidyl-tyrosine phosphorylation', 'positive regulation of calcium-mediated signaling', 'positive regulation of CD4-positive, alpha-beta T cell proliferation', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cell-matrix adhesion', 'positive regulation of gene expression', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-2 production', 'positive regulation of interleukin-4 production', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of T cell anergy', 'positive regulation of T cell proliferation', 'positive thymic T cell selection', 'protein-containing complex assembly', 'regulation of apoptotic process', 'signal complex assembly', 'smoothened signaling pathway', 'T cell activation', 'T cell anergy', 'T cell costimulation', 'T cell receptor signaling pathway', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Insulin
95
Insulin
31
8.8
67
0.17
P01308P01318['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['cellular response to palmitoleic acid', 'glucose metabolic process', 'response to L-arginine']
Pannexin-1
426
Pannexin-1
426
7.3
nan
nan
Q96RD7Q96RD7['calcium ion transport', 'cation transport', 'cell-cell signaling', 'oogenesis', 'positive regulation of interleukin-1 alpha production', 'positive regulation of interleukin-1 beta production', 'positive regulation of macrophage cytokine production', 'response to ATP', 'response to ischemia']['calcium ion transport', 'cation transport', 'cell-cell signaling', 'oogenesis', 'positive regulation of interleukin-1 alpha production', 'positive regulation of interleukin-1 beta production', 'positive regulation of macrophage cytokine production', 'response to ATP', 'response to ischemia']
Syntaxin-1A
271
Vesicle-associated membrane protein 2
36
2.0
53
0.93
P32851P63045['calcium-ion regulated exocytosis', 'exocytosis', 'hormone secretion', 'insulin secretion', 'intracellular protein transport', 'modulation of excitatory postsynaptic potential', 'neurotransmitter transport', 'positive regulation of calcium ion-dependent exocytosis', 'positive regulation of catecholamine secretion', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of exocytosis', 'positive regulation of neurotransmitter secretion', 'positive regulation of norepinephrine secretion', 'protein localization to membrane', 'protein sumoylation', 'regulated exocytosis', 'regulation of exocytosis', 'regulation of synaptic vesicle priming', 'response to gravity', 'secretion by cell', 'SNARE complex assembly', 'synaptic vesicle docking', 'synaptic vesicle endocytosis', 'synaptic vesicle exocytosis', 'synaptic vesicle fusion to presynaptic active zone membrane', 'vesicle docking', 'vesicle fusion']['calcium-ion regulated exocytosis', 'cellular response to insulin stimulus', 'eosinophil degranulation', 'exocytic insertion of neurotransmitter receptor to postsynaptic membrane', 'Golgi to plasma membrane protein transport', 'hormone secretion', 'long-term synaptic potentiation', 'membrane fusion', 'positive regulation of intracellular protein transport', 'protein transport', 'protein-containing complex assembly', 'regulated exocytosis', 'regulation of delayed rectifier potassium channel activity', 'regulation of exocytosis', 'regulation of synaptic vesicle recycling', 'regulation of vesicle-mediated transport', 'response to glucose', 'SNARE complex assembly', 'synaptic vesicle docking', 'synaptic vesicle endocytosis', 'synaptic vesicle exocytosis', 'vesicle fusion', 'vesicle-mediated transport']
Major prion protein
214
Major prion protein
214
4.9
78
0.26
P04273P04273['activation of protein kinase activity', 'calcium-mediated signaling using intracellular calcium source', 'cell cycle', 'cellular response to amyloid-beta', 'cellular response to copper ion', 'cellular response to xenobiotic stimulus', 'learning or memory', 'negative regulation of activated T cell proliferation', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of calcineurin-NFAT signaling cascade', 'negative regulation of dendritic spine maintenance', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-17 production', 'negative regulation of interleukin-2 production', 'negative regulation of protein phosphorylation', 'negative regulation of T cell receptor signaling pathway', 'neuron projection maintenance', 'positive regulation of neuron apoptotic process', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein targeting to membrane', 'positive regulation of protein tyrosine kinase activity', 'protein destabilization', 'protein homooligomerization', 'regulation of calcium ion import across plasma membrane', 'regulation of glutamate receptor signaling pathway', 'regulation of intracellular calcium activated chloride channel activity', 'regulation of potassium ion transmembrane transport', 'response to oxidative stress']['activation of protein kinase activity', 'calcium-mediated signaling using intracellular calcium source', 'cell cycle', 'cellular response to amyloid-beta', 'cellular response to copper ion', 'cellular response to xenobiotic stimulus', 'learning or memory', 'negative regulation of activated T cell proliferation', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of calcineurin-NFAT signaling cascade', 'negative regulation of dendritic spine maintenance', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of interferon-gamma production', 'negative regulation of interleukin-17 production', 'negative regulation of interleukin-2 production', 'negative regulation of protein phosphorylation', 'negative regulation of T cell receptor signaling pathway', 'neuron projection maintenance', 'positive regulation of neuron apoptotic process', 'positive regulation of protein localization to plasma membrane', 'positive regulation of protein targeting to membrane', 'positive regulation of protein tyrosine kinase activity', 'protein destabilization', 'protein homooligomerization', 'regulation of calcium ion import across plasma membrane', 'regulation of glutamate receptor signaling pathway', 'regulation of intracellular calcium activated chloride channel activity', 'regulation of potassium ion transmembrane transport', 'response to oxidative stress']
Sodium channel protein type 4 subunit alpha
1024
Sodium channel subunit beta-1
181
8.8
59
0.19
P35499Q07699['membrane depolarization during action potential', 'muscle contraction', 'neuronal action potential', 'regulation of ion transmembrane transport', 'regulation of skeletal muscle contraction by action potential', 'sodium ion transmembrane transport', 'sodium ion transport']['axon guidance', 'cardiac conduction', 'cardiac muscle cell action potential involved in contraction', 'cardiac muscle contraction', 'cell adhesion', 'corticospinal neuron axon guidance', 'locomotion', 'membrane depolarization', 'membrane depolarization during cardiac muscle cell action potential', 'membrane depolarization during Purkinje myocyte cell action potential', 'neuronal action potential propagation', 'positive regulation of neuron projection development', 'positive regulation of sodium ion transport', 'regulation of atrial cardiac muscle cell membrane depolarization', 'regulation of heart rate by cardiac conduction', 'regulation of sodium ion transmembrane transporter activity', 'regulation of ventricular cardiac muscle cell membrane repolarization', 'sodium ion transmembrane transport']
Eukaryotic translation initiation factor 3 subunit C
443
40S ribosomal protein S27
59
4.9
70
0.29
Q99613P42677['formation of cytoplasmic translation initiation complex', 'positive regulation of mRNA binding', 'positive regulation of translation', 'translational initiation']['cytoplasmic translation', 'ribosomal small subunit assembly', 'rRNA processing', 'translation']
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
128
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
116
9.8
85
0.12
P15690P42028['apoptotic mitochondrial changes', 'ATP metabolic process', 'cellular respiration', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'reactive oxygen species metabolic process', 'regulation of mitochondrial membrane potential']['aerobic respiration', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'response to oxidative stress']
Glycoprotein hormones alpha chain
56
Choriogonadotropin subunit beta 3
58
9.1
82
0.13
P01215P0DN86['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['apoptotic process', 'cell-cell signaling', 'female gamete generation', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'signal transduction']
Glycoprotein hormones alpha chain
83
Choriogonadotropin subunit beta 3
120
9.1
90
0.12
P01215P0DN86['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['apoptotic process', 'cell-cell signaling', 'female gamete generation', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'signal transduction']
Protein tweety homolog 2
101
Protein tweety homolog 2
101
5.0
73
0.27
Q3TH73Q3TH73[][]
Transformation/transcription domain-associated protein
2639
Transcriptional adapter 1
263
7.8
81
0.16
F2Z2U4Q96BN2['histone acetylation', 'phosphorylation', 'positive regulation of response to stimulus', 'regulation of cellular response to stress', 'regulation of macromolecule metabolic process', 'regulation of nucleobase-containing compound metabolic process']['histone H3 acetylation', 'monoubiquitinated histone deubiquitination', 'monoubiquitinated histone H2A deubiquitination', 'positive regulation of transcription, DNA-templated', 'regulation of DNA repair', 'regulation of RNA splicing', 'regulation of transcription by RNA polymerase II']
Voltage-dependent calcium channel gamma-2 subunit
63
Voltage-dependent calcium channel gamma-2 subunit
63
8.7
69
0.17
O88602O88602['eye blink reflex', 'membrane depolarization', 'membrane hyperpolarization', 'nervous system process', 'neuromuscular junction development', 'neurotransmitter receptor internalization', 'neurotransmitter receptor localization to postsynaptic specialization membrane', 'neurotransmitter receptor transport, postsynaptic endosome to lysosome', 'positive regulation of AMPA receptor activity', 'positive regulation of protein localization to basolateral plasma membrane', 'positive regulation of synaptic transmission, glutamatergic', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein targeting to membrane', 'regulation of AMPA receptor activity', 'regulation of membrane potential', 'regulation of postsynaptic membrane neurotransmitter receptor levels', 'regulation of postsynaptic neurotransmitter receptor activity', 'response to calcium ion', 'transmission of nerve impulse']['eye blink reflex', 'membrane depolarization', 'membrane hyperpolarization', 'nervous system process', 'neuromuscular junction development', 'neurotransmitter receptor internalization', 'neurotransmitter receptor localization to postsynaptic specialization membrane', 'neurotransmitter receptor transport, postsynaptic endosome to lysosome', 'positive regulation of AMPA receptor activity', 'positive regulation of protein localization to basolateral plasma membrane', 'positive regulation of synaptic transmission, glutamatergic', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein targeting to membrane', 'regulation of AMPA receptor activity', 'regulation of membrane potential', 'regulation of postsynaptic membrane neurotransmitter receptor levels', 'regulation of postsynaptic neurotransmitter receptor activity', 'response to calcium ion', 'transmission of nerve impulse']
Guanine nucleotide-binding protein G(i) subunit alpha-1
214
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
204
9.8
65
0.16
P63096P62871['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell cycle', 'cell division', 'cellular response to forskolin', 'G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to cell cortex', 'regulation of cAMP-mediated signaling', 'regulation of mitotic spindle organization', 'response to peptide hormone']['adenylate cyclase-activating dopamine receptor signaling pathway', 'cellular response to catecholamine stimulus', 'cellular response to prostaglandin E stimulus', 'G protein-coupled receptor signaling pathway']
LHFPL tetraspan subfamily member 5 protein
35
LHFPL tetraspan subfamily member 5 protein
35
5.0
78
0.26
Q4KL25Q4KL25['auditory receptor cell stereocilium organization', 'detection of mechanical stimulus involved in sensory perception', 'detection of mechanical stimulus involved in sensory perception of sound', 'ion transport', 'sensory perception of sound']['auditory receptor cell stereocilium organization', 'detection of mechanical stimulus involved in sensory perception', 'detection of mechanical stimulus involved in sensory perception of sound', 'ion transport', 'sensory perception of sound']
Glutamate receptor 1
323
Glutamate receptor 2
78
9.0
70
0.16
P19490P19491['cellular response to amine stimulus', 'cellular response to amino acid stimulus', 'cellular response to ammonium ion', 'cellular response to dsRNA', 'cellular response to growth factor stimulus', 'cellular response to organic cyclic compound', 'cellular response to peptide hormone stimulus', 'chemical synaptic transmission', 'long-term memory', 'long-term synaptic depression', 'modulation of chemical synaptic transmission', 'neuronal action potential', 'positive regulation of membrane potential', 'positive regulation of synaptic transmission', 'receptor internalization', 'regulation of postsynaptic membrane potential', 'regulation of receptor recycling', 'regulation of synaptic plasticity', 'response to arsenic-containing substance', 'response to cocaine', 'response to electrical stimulus', 'response to estradiol', 'response to fungicide', 'response to lithium ion', 'response to organic cyclic compound', 'response to peptide hormone', 'response to toxic substance', 'response to xenobiotic stimulus', 'spinal cord development', 'synaptic transmission, glutamatergic']['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']
Ferritin heavy chain
169
Ferritin heavy chain
27
2.0
50
0.99
P09528P09528['immune response', 'intracellular sequestering of iron ion', 'iron ion transport', 'negative regulation of cell population proliferation', 'negative regulation of fibroblast proliferation', 'negative regulation of necrotic cell death']['immune response', 'intracellular sequestering of iron ion', 'iron ion transport', 'negative regulation of cell population proliferation', 'negative regulation of fibroblast proliferation', 'negative regulation of necrotic cell death']
Sodium channel protein type 9 subunit alpha
1185
Sodium channel subunit beta-1
181
10.0
59
0.17
Q15858Q07699['behavioral response to formalin induced pain', 'inflammatory response', 'membrane depolarization during action potential', 'negative regulation of action potential', 'neuronal action potential', 'post-embryonic development', 'regulation of ion transmembrane transport', 'response to cold', 'response to heat', 'response to toxic substance', 'sensory perception of pain', 'sodium ion transmembrane transport', 'sodium ion transport']['axon guidance', 'cardiac conduction', 'cardiac muscle cell action potential involved in contraction', 'cardiac muscle contraction', 'cell adhesion', 'corticospinal neuron axon guidance', 'locomotion', 'membrane depolarization', 'membrane depolarization during cardiac muscle cell action potential', 'membrane depolarization during Purkinje myocyte cell action potential', 'neuronal action potential propagation', 'positive regulation of neuron projection development', 'positive regulation of sodium ion transport', 'regulation of atrial cardiac muscle cell membrane depolarization', 'regulation of heart rate by cardiac conduction', 'regulation of sodium ion transmembrane transporter activity', 'regulation of ventricular cardiac muscle cell membrane repolarization', 'sodium ion transmembrane transport']
Sodium channel subunit beta-2
55
Sodium channel protein type 3 subunit alpha
911
2.0
64
0.77
O60939Q9NY46['cardiac muscle cell action potential involved in contraction', 'cardiac muscle contraction', 'chemical synaptic transmission', 'gene expression', 'membrane depolarization during cardiac muscle cell action potential', 'nervous system development', 'regulation of atrial cardiac muscle cell membrane depolarization', 'regulation of heart rate by cardiac conduction', 'regulation of sodium ion transmembrane transporter activity', 'response to heat', 'response to pyrethroid', 'sodium ion transmembrane transport']['membrane depolarization during action potential', 'neuronal action potential', 'regulation of ion transmembrane transport', 'sodium ion transmembrane transport', 'sodium ion transport']
DNA-directed RNA polymerase subunit
1402
DNA-directed RNA polymerase subunit beta
1232
9.8
75
0.14
I3LJR4I3LGP4['transcription by RNA polymerase II']['transcription by RNA polymerase II']
Isoform 1 of Extracellular calcium-sensing receptor
131
Isoform 1 of Extracellular calcium-sensing receptor
131
5.0
48
0.42
P41180-1P41180-1[][]
Apoptotic protease-activating factor 1
115
Apoptotic protease-activating factor 1
258
8.9
76
0.15
O14727O14727['activation of cysteine-type endopeptidase activity', 'activation of cysteine-type endopeptidase activity involved in apoptotic process', 'activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c', 'aging', 'apoptotic process', 'cardiac muscle cell apoptotic process', 'cell differentiation', 'cellular response to transforming growth factor beta stimulus', 'forebrain development', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'kidney development', 'nervous system development', 'neural tube closure', 'neuron apoptotic process', 'positive regulation of apoptotic process', 'positive regulation of apoptotic signaling pathway', 'regulation of apoptotic DNA fragmentation', 'regulation of apoptotic process', 'response to G1 DNA damage checkpoint signaling', 'response to hypoxia', 'response to nutrient']['activation of cysteine-type endopeptidase activity', 'activation of cysteine-type endopeptidase activity involved in apoptotic process', 'activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c', 'aging', 'apoptotic process', 'cardiac muscle cell apoptotic process', 'cell differentiation', 'cellular response to transforming growth factor beta stimulus', 'forebrain development', 'intrinsic apoptotic signaling pathway', 'intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress', 'kidney development', 'nervous system development', 'neural tube closure', 'neuron apoptotic process', 'positive regulation of apoptotic process', 'positive regulation of apoptotic signaling pathway', 'regulation of apoptotic DNA fragmentation', 'regulation of apoptotic process', 'response to G1 DNA damage checkpoint signaling', 'response to hypoxia', 'response to nutrient']
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
25
Guanine nucleotide-binding protein G(T) subunit gamma-T1
37
10.0
55
0.18
P62871P02698['adenylate cyclase-activating dopamine receptor signaling pathway', 'cellular response to catecholamine stimulus', 'cellular response to prostaglandin E stimulus', 'G protein-coupled receptor signaling pathway']['G protein-coupled receptor signaling pathway']
Voltage-dependent calcium channel gamma-2 subunit
63
Voltage-dependent calcium channel gamma-2 subunit
63
7.8
67
0.19
Q9Y698Q9Y698['eye blink reflex', 'membrane depolarization', 'membrane hyperpolarization', 'neuromuscular junction development', 'neurotransmitter receptor internalization', 'neurotransmitter receptor localization to postsynaptic specialization membrane', 'neurotransmitter receptor transport, postsynaptic endosome to lysosome', 'positive regulation of AMPA receptor activity', 'positive regulation of protein localization to basolateral plasma membrane', 'positive regulation of synaptic transmission, glutamatergic', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein targeting to membrane', 'regulation of AMPA receptor activity', 'response to calcium ion', 'transmission of nerve impulse']['eye blink reflex', 'membrane depolarization', 'membrane hyperpolarization', 'neuromuscular junction development', 'neurotransmitter receptor internalization', 'neurotransmitter receptor localization to postsynaptic specialization membrane', 'neurotransmitter receptor transport, postsynaptic endosome to lysosome', 'positive regulation of AMPA receptor activity', 'positive regulation of protein localization to basolateral plasma membrane', 'positive regulation of synaptic transmission, glutamatergic', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein targeting to membrane', 'regulation of AMPA receptor activity', 'response to calcium ion', 'transmission of nerve impulse']
COP9 signalosome complex subunit 3
383
COP9 signalosome complex subunit 6
299
10.0
78
0.13
Q9UNS2Q7L5N1['in utero embryonic development', 'protein deneddylation', 'protein neddylation', 'regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator', 'regulation of protein neddylation', 'response to light stimulus', 'signal transduction', 'ubiquitin-dependent protein catabolic process']['protein deneddylation', 'protein neddylation', 'regulation of protein neddylation']
von Willebrand factor
1142
von Willebrand factor
1142
2.0
66
0.75
P04275P04275['blood coagulation', 'cell adhesion', 'cell-substrate adhesion', 'hemostasis', 'platelet activation', 'positive regulation of intracellular signal transduction', 'response to wounding']['blood coagulation', 'cell adhesion', 'cell-substrate adhesion', 'hemostasis', 'platelet activation', 'positive regulation of intracellular signal transduction', 'response to wounding']
Glutamate receptor 1
75
Glutamate receptor
330
7.9
71
0.18
P23818G5E8H1['cellular response to ammonium ion', 'chemical synaptic transmission', 'long-term memory', 'long-term synaptic depression', 'modulation of chemical synaptic transmission', 'neuronal action potential', 'positive regulation of membrane potential', 'positive regulation of synaptic transmission', 'receptor internalization', 'regulation of postsynaptic membrane potential', 'regulation of receptor recycling', 'regulation of synaptic plasticity', 'response to toxic substance'][]
Voltage-dependent calcium channel gamma-3 subunit
589
Voltage-dependent calcium channel gamma-3 subunit
589
6.4
86
0.18
Q8VHX0Q8VHX0['neurotransmitter receptor internalization', 'neurotransmitter receptor localization to postsynaptic specialization membrane', 'neurotransmitter receptor transport, postsynaptic endosome to lysosome', 'positive regulation of AMPA receptor activity', 'positive regulation of synaptic transmission, glutamatergic', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein localization', 'protein targeting', 'regulation of AMPA receptor activity', 'transmission of nerve impulse']['neurotransmitter receptor internalization', 'neurotransmitter receptor localization to postsynaptic specialization membrane', 'neurotransmitter receptor transport, postsynaptic endosome to lysosome', 'positive regulation of AMPA receptor activity', 'positive regulation of synaptic transmission, glutamatergic', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein localization', 'protein targeting', 'regulation of AMPA receptor activity', 'transmission of nerve impulse']
Kinetochore protein Spc25
137
Kinetochore protein Spc24
111
7.9
54
0.24
Q9HBM1C9JGC4['attachment of spindle microtubules to kinetochore', 'cell division', 'chromosome segregation', 'mitotic spindle assembly checkpoint signaling', 'mitotic spindle organization']['attachment of spindle microtubules to kinetochore', 'cell division', 'chromosome segregation', 'mitotic spindle assembly checkpoint signaling']
Lutropin-choriogonadotropic hormone receptor
131
Choriogonadotropin subunit beta 3
113
9.8
80
0.13
P22888P0DN86['activation of adenylate cyclase activity', 'adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'arachidonic acid secretion', 'cellular response to gonadotropin stimulus', 'cellular response to luteinizing hormone stimulus', 'central nervous system development', 'cognition', 'development of secondary male sexual characteristics', 'G protein-coupled receptor signaling pathway', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'hormone-mediated signaling pathway', 'luteinizing hormone signaling pathway', 'male genitalia development', 'male gonad development', 'ovarian follicle development', 'ovulation cycle process', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of calcium ion transport into cytosol', 'positive regulation of calcium-mediated signaling', 'positive regulation of hormone biosynthetic process', 'positive regulation of inositol trisphosphate biosynthetic process', 'positive regulation of release of sequestered calcium ion into cytosol', 'protein targeting to lysosome', 'regulation of steroid hormone biosynthetic process', 'response to xenobiotic stimulus', 'seminiferous tubule development', 'spermatogenesis', 'uterus development']['apoptotic process', 'cell-cell signaling', 'female gamete generation', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'signal transduction']
DNA-directed RNA polymerase III subunit RPC1
72
DNA-directed RNA polymerase III subunit RPC2
1092
9.0
68
0.16
O14802Q9NW08['defense response to virus', 'innate immune response', 'positive regulation of interferon-beta production', 'transcription, DNA-templated']['defense response to virus', 'innate immune response', 'positive regulation of innate immune response', 'positive regulation of interferon-beta production', 'transcription, DNA-templated']
Mucin-2
1090
Mucin-2
1088
9.0
79
0.14
A0A0G2JR65A0A0G2JR65[][]
Clathrin heavy chain 1
1573
Clathrin light chain B
198
8.9
70
0.16
P49951P04975['amyloid-beta clearance by transcytosis', 'autophagy', 'cell division', 'clathrin coat assembly', 'clathrin-dependent endocytosis', 'intracellular protein transport', 'mitotic cell cycle', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of protein localization to plasma membrane', 'receptor internalization', 'receptor-mediated endocytosis', 'regulation of mitotic spindle organization', 'retrograde transport, endosome to Golgi', 'transferrin transport']['clathrin-dependent endocytosis', 'intracellular protein transport']
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
286
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
225
7.8
87
0.15
P49821P19404['aerobic respiration', 'mitochondrial ATP synthesis coupled electron transport', 'mitochondrial electron transport, NADH to ubiquinone', 'proton motive force-driven mitochondrial ATP synthesis']['aerobic respiration', 'cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development', 'proton motive force-driven mitochondrial ATP synthesis']
Proteasome subunit alpha type-1
148
26S proteasome regulatory subunit 6A
390
9.1
88
0.12
P18420Q6P6U2['immune system process', 'negative regulation of inflammatory response to antigenic stimulus', 'proteasomal protein catabolic process', 'ubiquitin-dependent protein catabolic process']['protein catabolic process']
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
225
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
286
7.8
98
0.13
P04394P25708['cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development']['mitochondrial electron transport, NADH to ubiquinone']
Glutamate receptor 1
323
Glutamate receptor 2
330
9.0
70
0.16
P19490P19491['cellular response to amine stimulus', 'cellular response to amino acid stimulus', 'cellular response to ammonium ion', 'cellular response to dsRNA', 'cellular response to growth factor stimulus', 'cellular response to organic cyclic compound', 'cellular response to peptide hormone stimulus', 'chemical synaptic transmission', 'long-term memory', 'long-term synaptic depression', 'modulation of chemical synaptic transmission', 'neuronal action potential', 'positive regulation of membrane potential', 'positive regulation of synaptic transmission', 'receptor internalization', 'regulation of postsynaptic membrane potential', 'regulation of receptor recycling', 'regulation of synaptic plasticity', 'response to arsenic-containing substance', 'response to cocaine', 'response to electrical stimulus', 'response to estradiol', 'response to fungicide', 'response to lithium ion', 'response to organic cyclic compound', 'response to peptide hormone', 'response to toxic substance', 'response to xenobiotic stimulus', 'spinal cord development', 'synaptic transmission, glutamatergic']['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']
Transcription activator BRG1
423
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
492
9.1
64
0.17
P51532Q96GM5['chromatin remodeling', 'negative regulation of androgen receptor signaling pathway', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of transcription, DNA-templated', 'nervous system development', 'neural retina development', 'nucleosome disassembly', 'positive regulation by host of viral transcription', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of double-strand break repair', 'positive regulation of glucose mediated signaling pathway', 'positive regulation of miRNA transcription', 'positive regulation of myoblast differentiation', 'positive regulation of stem cell population maintenance', 'positive regulation of T cell differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription of nucleolar large rRNA by RNA polymerase I', 'positive regulation of transcription, DNA-templated', 'positive regulation of Wnt signaling pathway', 'regulation of G0 to G1 transition', 'regulation of G1/S transition of mitotic cell cycle', 'regulation of mitotic metaphase/anaphase transition', 'regulation of nucleotide-excision repair', 'regulation of transcription by RNA polymerase II', 'RNA polymerase I preinitiation complex assembly']['cellular response to fatty acid', 'chromatin remodeling', 'epigenetic maintenance of chromatin in transcription-competent conformation', 'negative regulation of cell differentiation', 'nervous system development', 'nucleosome disassembly', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of double-strand break repair', 'positive regulation of myoblast differentiation', 'positive regulation of stem cell population maintenance', 'positive regulation of T cell differentiation', 'regulation of G0 to G1 transition', 'regulation of G1/S transition of mitotic cell cycle', 'regulation of mitotic metaphase/anaphase transition', 'regulation of nucleotide-excision repair', 'regulation of transcription by RNA polymerase II']
Kinetochore protein Spc25
232
Kinetochore protein Spc24
134
4.4
67
0.34
Q9HBM1C9JGC4['attachment of spindle microtubules to kinetochore', 'cell division', 'chromosome segregation', 'mitotic spindle assembly checkpoint signaling', 'mitotic spindle organization']['attachment of spindle microtubules to kinetochore', 'cell division', 'chromosome segregation', 'mitotic spindle assembly checkpoint signaling']
Isoform Glur5-2 of Glutamate receptor ionotropic, kainate 1
97
Isoform Glur5-2 of Glutamate receptor ionotropic, kainate 1
97
9.0
72
0.15
P22756-2P22756-2[][]
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
150
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
183
7.8
95
0.13
O00217O75251['aerobic respiration', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'proton motive force-driven mitochondrial ATP synthesis', 'response to oxidative stress']['aerobic respiration', 'electron transport coupled proton transport', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'proton motive force-driven mitochondrial ATP synthesis']
Cytochrome c oxidase subunit 7C, mitochondrial
42
Cytochrome c oxidase subunit 8A, mitochondrial
47
8.1
66
0.19
P15954P10176['cellular respiration', 'generation of precursor metabolites and energy', 'mitochondrial electron transport, cytochrome c to oxygen']['cellular respiration', 'generation of precursor metabolites and energy', 'mitochondrial electron transport, cytochrome c to oxygen']
Mucin-2
1088
Mucin-2
1117
9.8
69
0.15
A0A0G2JR65A0A0G2JR65[][]
Calcium homeostasis modulator protein 2
126
Calcium homeostasis modulator protein 2
180
8.1
79
0.16
Q9HA72Q9HA72['positive regulation of apoptotic process']['positive regulation of apoptotic process']
Voltage-dependent calcium channel gamma-2 subunit
315
Voltage-dependent calcium channel gamma-2 subunit
63
8.3
70
0.17
O88602O88602['eye blink reflex', 'membrane depolarization', 'membrane hyperpolarization', 'nervous system process', 'neuromuscular junction development', 'neurotransmitter receptor internalization', 'neurotransmitter receptor localization to postsynaptic specialization membrane', 'neurotransmitter receptor transport, postsynaptic endosome to lysosome', 'positive regulation of AMPA receptor activity', 'positive regulation of protein localization to basolateral plasma membrane', 'positive regulation of synaptic transmission, glutamatergic', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein targeting to membrane', 'regulation of AMPA receptor activity', 'regulation of membrane potential', 'regulation of postsynaptic membrane neurotransmitter receptor levels', 'regulation of postsynaptic neurotransmitter receptor activity', 'response to calcium ion', 'transmission of nerve impulse']['eye blink reflex', 'membrane depolarization', 'membrane hyperpolarization', 'nervous system process', 'neuromuscular junction development', 'neurotransmitter receptor internalization', 'neurotransmitter receptor localization to postsynaptic specialization membrane', 'neurotransmitter receptor transport, postsynaptic endosome to lysosome', 'positive regulation of AMPA receptor activity', 'positive regulation of protein localization to basolateral plasma membrane', 'positive regulation of synaptic transmission, glutamatergic', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein targeting to membrane', 'regulation of AMPA receptor activity', 'regulation of membrane potential', 'regulation of postsynaptic membrane neurotransmitter receptor levels', 'regulation of postsynaptic neurotransmitter receptor activity', 'response to calcium ion', 'transmission of nerve impulse']
DNA-directed RNA polymerase I subunit RPA2
93
DNA-directed RNA polymerases I, II, and III subunit RPABC4
22
9.8
50
0.2
Q9H9Y6P53803['embryo implantation', 'neural crest formation', 'nucleologenesis', 'rRNA transcription']['regulation of transcription by RNA polymerase I', 'transcription by RNA polymerase II', 'transcription by RNA polymerase III']
Voltage-dependent calcium channel gamma-2 subunit
315
Voltage-dependent calcium channel gamma-2 subunit
63
7.3
68
0.2
Q9Y698Q9Y698['eye blink reflex', 'membrane depolarization', 'membrane hyperpolarization', 'neuromuscular junction development', 'neurotransmitter receptor internalization', 'neurotransmitter receptor localization to postsynaptic specialization membrane', 'neurotransmitter receptor transport, postsynaptic endosome to lysosome', 'positive regulation of AMPA receptor activity', 'positive regulation of protein localization to basolateral plasma membrane', 'positive regulation of synaptic transmission, glutamatergic', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein targeting to membrane', 'regulation of AMPA receptor activity', 'response to calcium ion', 'transmission of nerve impulse']['eye blink reflex', 'membrane depolarization', 'membrane hyperpolarization', 'neuromuscular junction development', 'neurotransmitter receptor internalization', 'neurotransmitter receptor localization to postsynaptic specialization membrane', 'neurotransmitter receptor transport, postsynaptic endosome to lysosome', 'positive regulation of AMPA receptor activity', 'positive regulation of protein localization to basolateral plasma membrane', 'positive regulation of synaptic transmission, glutamatergic', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein targeting to membrane', 'regulation of AMPA receptor activity', 'response to calcium ion', 'transmission of nerve impulse']
TMEM106B protein
254
TMEM106B protein
254
4.9
62
0.33
Q8N353Q8N353[][]
4F2 cell-surface antigen heavy chain
211
Large neutral amino acids transporter small subunit 1
164
2.0
49
1.01
J3KPF3Q01650['amino acid transport', 'carbohydrate metabolic process']['amino acid import across plasma membrane', 'cellular response to glucose starvation', 'cellular response to L-arginine', 'cellular response to lipopolysaccharide', 'isoleucine transport', 'L-leucine import across plasma membrane', 'L-tryptophan transmembrane transport', 'leucine import across plasma membrane', 'liver regeneration', 'negative regulation of autophagy', 'negative regulation of gene expression', 'negative regulation of vascular associated smooth muscle cell apoptotic process', 'neutral amino acid transport', 'odontogenesis', 'phenylalanine transport', 'positive regulation of cytokine production involved in immune response', 'positive regulation of glial cell proliferation', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-17 production', 'positive regulation of interleukin-4 production', 'positive regulation of leucine import across plasma membrane', 'response to hyperoxia', 'response to muscle activity', 'thyroid hormone transport', 'transport across blood-brain barrier', 'valine transport', 'xenobiotic transport']
Neurotensin receptor type 1
171
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
8.9
67
0.17
P30989P63096['adult locomotory behavior', 'chemical synaptic transmission', 'D-aspartate import across plasma membrane', 'detection of temperature stimulus involved in sensory perception of pain', 'G protein-coupled receptor signaling pathway', 'inositol phosphate catabolic process', 'L-glutamate import across plasma membrane', 'learning', 'negative regulation of apoptotic process', 'negative regulation of release of sequestered calcium ion into cytosol', 'negative regulation of systemic arterial blood pressure', 'neuropeptide signaling pathway', 'positive regulation of apoptotic process', 'positive regulation of arachidonic acid secretion', 'positive regulation of cation channel activity', 'positive regulation of gamma-aminobutyric acid secretion', 'positive regulation of gene expression', 'positive regulation of glutamate secretion', 'positive regulation of inhibitory postsynaptic potential', 'positive regulation of inositol phosphate biosynthetic process', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of release of sequestered calcium ion into cytosol', 'regulation of action potential', 'regulation of membrane depolarization', 'regulation of respiratory gaseous exchange', 'regulation of sensory perception of pain', 'response to lipid', 'temperature homeostasis']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell cycle', 'cell division', 'cellular response to forskolin', 'G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to cell cortex', 'regulation of cAMP-mediated signaling', 'regulation of mitotic spindle organization', 'response to peptide hormone']
Glycoprotein hormones alpha chain
111
Choriogonadotropin subunit beta 3
58
8.9
74
0.15
P01215P0DN86['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['apoptotic process', 'cell-cell signaling', 'female gamete generation', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'signal transduction']
Syntaxin-1A
205
Vesicle-associated membrane protein 2
36
2.0
51
0.97
P32851P63027['calcium-ion regulated exocytosis', 'exocytosis', 'hormone secretion', 'insulin secretion', 'intracellular protein transport', 'modulation of excitatory postsynaptic potential', 'neurotransmitter transport', 'positive regulation of calcium ion-dependent exocytosis', 'positive regulation of catecholamine secretion', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of exocytosis', 'positive regulation of neurotransmitter secretion', 'positive regulation of norepinephrine secretion', 'protein localization to membrane', 'protein sumoylation', 'regulated exocytosis', 'regulation of exocytosis', 'regulation of synaptic vesicle priming', 'response to gravity', 'secretion by cell', 'SNARE complex assembly', 'synaptic vesicle docking', 'synaptic vesicle endocytosis', 'synaptic vesicle exocytosis', 'synaptic vesicle fusion to presynaptic active zone membrane', 'vesicle docking', 'vesicle fusion']['calcium-ion regulated exocytosis', 'cellular response to insulin stimulus', 'eosinophil degranulation', 'exocytosis', 'Golgi to plasma membrane protein transport', 'long-term synaptic potentiation', 'membrane fusion', 'positive regulation of intracellular protein transport', 'protein transport', 'protein-containing complex assembly', 'regulation of delayed rectifier potassium channel activity', 'regulation of exocytosis', 'regulation of vesicle-mediated transport', 'response to glucose', 'SNARE complex assembly', 'synaptic vesicle endocytosis', 'synaptic vesicle exocytosis', 'vesicle fusion', 'vesicle-mediated transport']
28S ribosomal protein S6, mitochondrial
105
28S ribosomal protein S18c, mitochondrial
69
4.9
51
0.4
P82931P82917['mitochondrial translation']['translation']
THO complex subunit 1
156
THO complex subunit 2
202
8.8
67
0.17
Q96FV9Q8NI27['apoptotic process', 'mRNA export from nucleus', 'mRNA processing', 'negative regulation of DNA damage checkpoint', 'negative regulation of isotype switching to IgA isotypes', 'positive regulation of DNA-templated transcription, elongation', 'regulation of DNA recombination', 'regulation of DNA-templated transcription, elongation', 'replication fork processing', 'RNA processing', 'RNA splicing', 'signal transduction', 'viral mRNA export from host cell nucleus']['blastocyst development', 'cell morphogenesis', 'generation of neurons', 'mRNA export from nucleus', 'mRNA processing', 'negative regulation of neuron projection development', 'neuron development', 'poly(A)+ mRNA export from nucleus', 'regulation of gene expression', 'regulation of mRNA export from nucleus', 'RNA splicing', 'stem cell division', 'viral mRNA export from host cell nucleus']
Clathrin heavy chain
1573
Clathrin light chain
188
9.8
52
0.2
C0MHR2F1S398['clathrin coat assembly', 'intracellular protein transport', 'mitotic cell cycle', 'receptor-mediated endocytosis']['clathrin-dependent endocytosis', 'intracellular protein transport']
DNA-directed RNA polymerase III subunit RPC3
439
DNA-directed RNA polymerase III subunit RPC6
287
9.8
85
0.12
Q9BUI4Q9H1D9['defense response to virus', 'innate immune response', 'positive regulation of innate immune response', 'positive regulation of interferon-beta production', 'regulation of transcription by RNA polymerase III', 'transcription, DNA-templated']['defense response to virus', 'innate immune response', 'positive regulation of innate immune response', 'positive regulation of interferon-beta production', 'regulation of transcription by RNA polymerase III', 'transcription by RNA polymerase III']
Glutamate receptor
350
Glutamate receptor
99
7.9
66
0.19
G3V9I2G3V9I2[][]
High affinity immunoglobulin epsilon receptor subunit alpha
156
Immunoglobulin heavy constant epsilon
335
2.7
37
1.01
P12319P01854['cell surface receptor signaling pathway', 'regulation of immune response']['adaptive immune response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
ATP synthase lipid-binding protein
125
ATP synthase lipid-binding protein
125
9.8
93
0.11
Q4VT52Q4VT52['proton motive force-driven ATP synthesis']['proton motive force-driven ATP synthesis']
Glycoprotein hormones alpha chain
83
Thyrotropin subunit beta
72
9.8
86
0.12
P01215P01222['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['anatomical structure morphogenesis', 'cell-cell signaling', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'response to calcium ion', 'response to estrogen', 'response to vitamin A']
DNA excision repair protein ERCC-8
178
DNA excision repair protein ERCC-6
730
9.1
79
0.14
Q13216Q03468['cellular response to DNA damage stimulus', 'double-strand break repair via classical nonhomologous end joining', 'positive regulation of DNA repair', 'proteasome-mediated ubiquitin-dependent protein catabolic process', 'protein autoubiquitination', 'protein polyubiquitination', 'regulation of transcription-coupled nucleotide-excision repair', 'response to oxidative stress', 'response to UV', 'response to X-ray', 'single strand break repair', 'transcription-coupled nucleotide-excision repair']['base-excision repair', 'chromatin remodeling', 'DNA damage checkpoint signaling', 'DNA protection', 'DNA repair', 'double-strand break repair via classical nonhomologous end joining', 'intrinsic apoptotic signaling pathway in response to DNA damage', 'JNK cascade', 'multicellular organism growth', 'negative regulation of double-strand break repair via nonhomologous end joining', 'neurogenesis', 'neuron differentiation', 'neuron projection development', 'photoreceptor cell maintenance', 'positive regulation of DNA repair', 'positive regulation of DNA-templated transcription, elongation', 'positive regulation of double-strand break repair via homologous recombination', 'positive regulation of histone acetylation', 'positive regulation of transcription by RNA polymerase I', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase III', 'positive regulation of transcription initiation from RNA polymerase II promoter', 'pyrimidine dimer repair', 'regulation of DNA-templated transcription, elongation', 'regulation of transcription elongation from RNA polymerase II promoter', 'response to gamma radiation', 'response to oxidative stress', 'response to superoxide', 'response to toxic substance', 'response to UV', 'response to UV-B', 'response to X-ray', 'single strand break repair', 'transcription by RNA polymerase II', 'transcription elongation from RNA polymerase I promoter', 'transcription-coupled nucleotide-excision repair']
C-C motif chemokine 20
33
C-C chemokine receptor type 6
36
7.8
69
0.18
P78556P51684['antimicrobial humoral immune response mediated by antimicrobial peptide', 'calcium-mediated signaling using intracellular calcium source', 'cell chemotaxis', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response to bacterium', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of T cell migration', 'signal transduction', 'T cell migration', 'thymocyte migration']['calcium-mediated signaling', 'cell chemotaxis', 'cellular defense response', 'chemotaxis', 'dendritic cell chemotaxis', 'DN2 thymocyte differentiation', 'DN3 thymocyte differentiation', 'humoral immune response', 'immune response', 'isotype switching to IgA isotypes', 'leukocyte migration involved in inflammatory response', 'lymphocyte migration', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of dendritic cell chemotaxis', 'positive regulation of flagellated sperm motility involved in capacitation', 'regulation of T cell migration', 'signal transduction', 'T cell migration', 'thymocyte migration']
Glutamate receptor ionotropic, kainate 3
99
Glutamate receptor ionotropic, kainate 3
99
7.9
63
0.2
P42264P42264['chemical synaptic transmission', 'G protein-coupled glutamate receptor signaling pathway', 'glutamate receptor signaling pathway', 'modulation of chemical synaptic transmission', 'negative regulation of synaptic transmission, glutamatergic', 'regulation of membrane potential', 'synaptic transmission, glutamatergic']['chemical synaptic transmission', 'G protein-coupled glutamate receptor signaling pathway', 'glutamate receptor signaling pathway', 'modulation of chemical synaptic transmission', 'negative regulation of synaptic transmission, glutamatergic', 'regulation of membrane potential', 'synaptic transmission, glutamatergic']
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
194
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
152
7.9
99
0.13
Q9DC70Q8K3J1['aerobic respiration', 'electron transport coupled proton transport', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'proton motive force-driven mitochondrial ATP synthesis']['aerobic respiration', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'proton motive force-driven mitochondrial ATP synthesis', 'response to oxidative stress']
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
225
5.2
81
0.24
P49821P19404['aerobic respiration', 'mitochondrial ATP synthesis coupled electron transport', 'mitochondrial electron transport, NADH to ubiquinone', 'proton motive force-driven mitochondrial ATP synthesis']['aerobic respiration', 'cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development', 'proton motive force-driven mitochondrial ATP synthesis']
DNA-directed RNA polymerase I subunit RPA2
535
DNA-directed RNA polymerase I subunit RPA49
85
4.7
77
0.27
Q9H9Y6Q9GZS1['embryo implantation', 'neural crest formation', 'nucleologenesis', 'rRNA transcription']['nucleolar large rRNA transcription by RNA polymerase I', 'RNA polymerase I preinitiation complex assembly', 'transcription elongation from RNA polymerase I promoter']
Potassium voltage-gated channel subfamily C member 1
83
Potassium voltage-gated channel subfamily C member 1
104
4.8
69
0.31
P48547P48547['cellular response to xenobiotic stimulus', 'cerebellum development', 'globus pallidus development', 'positive regulation of voltage-gated potassium channel activity', 'potassium ion transmembrane transport', 'potassium ion transport', 'protein homooligomerization', 'protein tetramerization', 'response to amine', 'response to auditory stimulus', 'response to fibroblast growth factor', 'response to light intensity', 'response to nerve growth factor', 'response to potassium ion', 'response to toxic substance']['cellular response to xenobiotic stimulus', 'cerebellum development', 'globus pallidus development', 'positive regulation of voltage-gated potassium channel activity', 'potassium ion transmembrane transport', 'potassium ion transport', 'protein homooligomerization', 'protein tetramerization', 'response to amine', 'response to auditory stimulus', 'response to fibroblast growth factor', 'response to light intensity', 'response to nerve growth factor', 'response to potassium ion', 'response to toxic substance']
Transmembrane protein 106B
253
Transmembrane protein 106B
253
9.7
47
0.22
Q9NUM4Q9NUM4['dendrite morphogenesis', 'lysosomal lumen acidification', 'lysosomal protein catabolic process', 'lysosomal transport', 'lysosome localization', 'lysosome organization', 'neuron cellular homeostasis', 'positive regulation of dendrite development', 'positive regulation of hydrolase activity', 'regulation of lysosome organization']['dendrite morphogenesis', 'lysosomal lumen acidification', 'lysosomal protein catabolic process', 'lysosomal transport', 'lysosome localization', 'lysosome organization', 'neuron cellular homeostasis', 'positive regulation of dendrite development', 'positive regulation of hydrolase activity', 'regulation of lysosome organization']
Insulin-like growth factor 1 receptor
702
Insulin-like growth factor 1 receptor
700
9.2
nan
nan
P08069P08069['aging', 'amyloid-beta clearance', 'axonogenesis', 'cardiac atrium development', 'cellular response to aldosterone', 'cellular response to amyloid-beta', 'cellular response to angiotensin', 'cellular response to dexamethasone stimulus', 'cellular response to estradiol stimulus', 'cellular response to glucose stimulus', 'cellular response to insulin-like growth factor stimulus', 'cellular response to mechanical stimulus', 'cellular response to progesterone stimulus', 'cellular response to testosterone stimulus', 'cellular response to transforming growth factor beta stimulus', 'cellular senescence', 'cerebellum development', 'dendritic spine maintenance', 'establishment of cell polarity', 'estrous cycle', 'glucose homeostasis', 'hippocampus development', 'immune response', 'insulin receptor signaling pathway', 'insulin-like growth factor receptor signaling pathway', 'negative regulation of apoptotic process', 'negative regulation of cholangiocyte apoptotic process', 'negative regulation of hepatocyte apoptotic process', 'negative regulation of MAPK cascade', 'negative regulation of muscle cell apoptotic process', 'peptidyl-tyrosine autophosphorylation', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol-mediated signaling', 'positive regulation of axon regeneration', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cold-induced thermogenesis', 'positive regulation of cytokinesis', 'positive regulation of DNA metabolic process', 'positive regulation of kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of osteoblast proliferation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein-containing complex disassembly', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of steroid hormone biosynthetic process', 'protein autophosphorylation', 'regulation of JNK cascade', 'response to ethanol', 'response to L-glutamate', 'response to nicotine', 'response to vitamin E', 'signal transduction', 'transcytosis', 'transmembrane receptor protein tyrosine kinase signaling pathway']['aging', 'amyloid-beta clearance', 'axonogenesis', 'cardiac atrium development', 'cellular response to aldosterone', 'cellular response to amyloid-beta', 'cellular response to angiotensin', 'cellular response to dexamethasone stimulus', 'cellular response to estradiol stimulus', 'cellular response to glucose stimulus', 'cellular response to insulin-like growth factor stimulus', 'cellular response to mechanical stimulus', 'cellular response to progesterone stimulus', 'cellular response to testosterone stimulus', 'cellular response to transforming growth factor beta stimulus', 'cellular senescence', 'cerebellum development', 'dendritic spine maintenance', 'establishment of cell polarity', 'estrous cycle', 'glucose homeostasis', 'hippocampus development', 'immune response', 'insulin receptor signaling pathway', 'insulin-like growth factor receptor signaling pathway', 'negative regulation of apoptotic process', 'negative regulation of cholangiocyte apoptotic process', 'negative regulation of hepatocyte apoptotic process', 'negative regulation of MAPK cascade', 'negative regulation of muscle cell apoptotic process', 'peptidyl-tyrosine autophosphorylation', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol-mediated signaling', 'positive regulation of axon regeneration', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cold-induced thermogenesis', 'positive regulation of cytokinesis', 'positive regulation of DNA metabolic process', 'positive regulation of kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of osteoblast proliferation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein-containing complex disassembly', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of steroid hormone biosynthetic process', 'protein autophosphorylation', 'regulation of JNK cascade', 'response to ethanol', 'response to L-glutamate', 'response to nicotine', 'response to vitamin E', 'signal transduction', 'transcytosis', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Bestrophin
108
Bestrophin
189
4.7
99
0.21
E1BF86E1BF86[][]
Glycoprotein hormones alpha chain
31
Thyrotropin subunit beta
22
8.4
49
0.24
P01215P01222['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['anatomical structure morphogenesis', 'cell-cell signaling', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'response to calcium ion', 'response to estrogen', 'response to vitamin A']
C-C chemokine receptor type 2
75
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
9.0
65
0.17
P41597P63096['blood vessel remodeling', 'calcium-mediated signaling', 'cell chemotaxis', 'cellular calcium ion homeostasis', 'cellular defense response', 'cellular homeostasis', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'dendritic cell chemotaxis', 'immune response', 'inflammatory response', 'inflammatory response to wounding', 'macrophage migration', 'monocyte extravasation', 'negative regulation of adenylate cyclase activity', 'negative regulation of angiogenesis', 'negative regulation of eosinophil degranulation', 'negative regulation of type 2 immune response', 'positive regulation of alpha-beta T cell proliferation', 'positive regulation of astrocyte chemotaxis', 'positive regulation of CD8-positive, alpha-beta T cell extravasation', 'positive regulation of cold-induced thermogenesis', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of hematopoietic stem cell migration', 'positive regulation of immune complex clearance by monocytes and macrophages', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-2 production', 'positive regulation of monocyte chemotaxis', 'positive regulation of monocyte extravasation', 'positive regulation of NMDA glutamate receptor activity', 'positive regulation of synaptic transmission, glutamatergic', 'positive regulation of T cell activation', 'positive regulation of T cell chemotaxis', 'positive regulation of T-helper 1 type immune response', 'positive regulation of thymocyte migration', 'positive regulation of tumor necrosis factor production', 'receptor signaling pathway via JAK-STAT', 'regulation of inflammatory response', 'regulation of T cell cytokine production', 'regulation of T cell differentiation', 'regulation of vascular endothelial growth factor production', 'response to wounding', 'sensory perception of pain', 'T-helper 17 cell chemotaxis']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell cycle', 'cell division', 'cellular response to forskolin', 'G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to cell cortex', 'regulation of cAMP-mediated signaling', 'regulation of mitotic spindle organization', 'response to peptide hormone']
Insulin receptor
714
Insulin receptor
714
7.4
22
0.62
P15208P15208['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'animal organ morphogenesis', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'male gonad development', 'male sex determination', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of protein phosphorylation', 'negative regulation of transporter activity', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of hydrogen peroxide metabolic process', 'regulation of transcription, DNA-templated', 'response to nutrient levels', 'response to tumor necrosis factor', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'viral entry into host cell']['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'animal organ morphogenesis', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'male gonad development', 'male sex determination', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of protein phosphorylation', 'negative regulation of transporter activity', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of hydrogen peroxide metabolic process', 'regulation of transcription, DNA-templated', 'response to nutrient levels', 'response to tumor necrosis factor', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'viral entry into host cell']
Insulin-like growth factor 1 receptor
701
Insulin-like growth factor 1 receptor
703
7.2
nan
nan
Q60751Q60751['adrenal gland development', 'amyloid-beta clearance', 'animal organ morphogenesis', 'axonogenesis', 'brain development', 'cellular response to amyloid-beta', 'cellular response to glucose stimulus', 'cellular response to insulin stimulus', 'cellular response to insulin-like growth factor stimulus', 'cellular response to transforming growth factor beta stimulus', 'cerebellum development', 'dendritic spine maintenance', 'epidermis development', 'establishment of cell polarity', 'estrous cycle', 'exocrine pancreas development', 'glucose homeostasis', 'immune response', 'insulin receptor signaling pathway', 'insulin-like growth factor receptor signaling pathway', 'male sex determination', 'mammary gland development', 'MAPK cascade', 'mitotic nuclear division', 'negative regulation of apoptotic process', 'negative regulation of cholangiocyte apoptotic process', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of hepatocyte apoptotic process', 'negative regulation of MAPK cascade', 'negative regulation of muscle cell apoptotic process', 'negative regulation of protein kinase B signaling', 'neuron projection development', 'peptidyl-tyrosine autophosphorylation', 'phosphatidylinositol-mediated signaling', 'positive regulation of axon regeneration', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cold-induced thermogenesis', 'positive regulation of cytokinesis', 'positive regulation of developmental growth', 'positive regulation of DNA metabolic process', 'positive regulation of kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of osteoblast proliferation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein-containing complex disassembly', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of steroid hormone biosynthetic process', 'positive regulation of transcription, DNA-templated', 'prostate gland epithelium morphogenesis', 'protein autophosphorylation', 'protein kinase B signaling', 'protein phosphorylation', 'regulation of JNK cascade', 'response to ethanol', 'response to L-glutamate', 'transcytosis', 'transmembrane receptor protein tyrosine kinase signaling pathway']['adrenal gland development', 'amyloid-beta clearance', 'animal organ morphogenesis', 'axonogenesis', 'brain development', 'cellular response to amyloid-beta', 'cellular response to glucose stimulus', 'cellular response to insulin stimulus', 'cellular response to insulin-like growth factor stimulus', 'cellular response to transforming growth factor beta stimulus', 'cerebellum development', 'dendritic spine maintenance', 'epidermis development', 'establishment of cell polarity', 'estrous cycle', 'exocrine pancreas development', 'glucose homeostasis', 'immune response', 'insulin receptor signaling pathway', 'insulin-like growth factor receptor signaling pathway', 'male sex determination', 'mammary gland development', 'MAPK cascade', 'mitotic nuclear division', 'negative regulation of apoptotic process', 'negative regulation of cholangiocyte apoptotic process', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of hepatocyte apoptotic process', 'negative regulation of MAPK cascade', 'negative regulation of muscle cell apoptotic process', 'negative regulation of protein kinase B signaling', 'neuron projection development', 'peptidyl-tyrosine autophosphorylation', 'phosphatidylinositol-mediated signaling', 'positive regulation of axon regeneration', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cold-induced thermogenesis', 'positive regulation of cytokinesis', 'positive regulation of developmental growth', 'positive regulation of DNA metabolic process', 'positive regulation of kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of osteoblast proliferation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein-containing complex disassembly', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of steroid hormone biosynthetic process', 'positive regulation of transcription, DNA-templated', 'prostate gland epithelium morphogenesis', 'protein autophosphorylation', 'protein kinase B signaling', 'protein phosphorylation', 'regulation of JNK cascade', 'response to ethanol', 'response to L-glutamate', 'transcytosis', 'transmembrane receptor protein tyrosine kinase signaling pathway']
COP9 signalosome complex subunit 6
266
COP9 signalosome complex subunit 7b
157
4.7
91
0.23
Q7L5N1Q9H9Q2['protein deneddylation', 'protein neddylation', 'regulation of protein neddylation']['COP9 signalosome assembly', 'protein deneddylation', 'protein neddylation', 'regulation of protein neddylation']
General transcription factor IIH subunit 3
142
General transcription factor IIH subunit 2
381
9.0
78
0.14
Q13889Q13888['DNA repair', 'nucleotide-excision repair', 'phosphorylation of RNA polymerase II C-terminal domain', 'transcription by RNA polymerase II']['G protein-coupled receptor internalization', 'nucleotide-excision repair', 'positive regulation of DNA helicase activity', 'regulation of transcription by RNA polymerase II', 'response to UV', 'transcription by RNA polymerase II', 'transcription initiation from RNA polymerase II promoter']
TMEM106B protein
293
TMEM106B protein
293
9.7
49
0.21
Q8N353Q8N353[][]
Mucin-2
1130
Mucin-2
1130
2.0
52
0.95
A0A0G2JR65A0A0G2JR65[][]
Insulin
100
Insulin
31
9.8
65
0.16
P01308P01318['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['cellular response to palmitoleic acid', 'glucose metabolic process', 'response to L-arginine']
Glycoprotein hormones alpha chain
108
Choriogonadotropin subunit beta 3
58
10.0
73
0.14
P01215P0DN86['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['apoptotic process', 'cell-cell signaling', 'female gamete generation', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'signal transduction']
Glycoprotein hormones alpha chain
83
Choriogonadotropin subunit beta 3
58
8.1
80
0.15
P01215P0DN86['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['apoptotic process', 'cell-cell signaling', 'female gamete generation', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'signal transduction']
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
Muscarinic acetylcholine receptor M4
133
3.8
73
0.36
P63096P08173['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell cycle', 'cell division', 'cellular response to forskolin', 'G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to cell cortex', 'regulation of cAMP-mediated signaling', 'regulation of mitotic spindle organization', 'response to peptide hormone']['adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway', 'cell surface receptor signaling pathway', 'chemical synaptic transmission', 'G protein-coupled acetylcholine receptor signaling pathway', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'regulation of locomotion', 'signal transduction']
Islet amyloid polypeptide
40
Islet amyloid polypeptide
40
9.8
57
0.18
P10997P10997['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'amylin receptor signaling pathway', 'amyloid fibril formation', 'apoptotic process', 'bone resorption', 'cell-cell signaling', 'eating behavior', 'negative regulation of amyloid fibril formation', 'negative regulation of bone resorption', 'negative regulation of cell population proliferation', 'negative regulation of mitochondrion organization', 'negative regulation of osteoclast differentiation', 'negative regulation of protein-containing complex assembly', 'osteoclast differentiation', 'positive regulation of apoptotic process', 'positive regulation of calcium ion import across plasma membrane', 'positive regulation of cell death', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'protein destabilization', 'protein homooligomerization', 'sensory perception of pain', 'signal transduction']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'amylin receptor signaling pathway', 'amyloid fibril formation', 'apoptotic process', 'bone resorption', 'cell-cell signaling', 'eating behavior', 'negative regulation of amyloid fibril formation', 'negative regulation of bone resorption', 'negative regulation of cell population proliferation', 'negative regulation of mitochondrion organization', 'negative regulation of osteoclast differentiation', 'negative regulation of protein-containing complex assembly', 'osteoclast differentiation', 'positive regulation of apoptotic process', 'positive regulation of calcium ion import across plasma membrane', 'positive regulation of cell death', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of MAPK cascade', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of protein kinase A signaling', 'positive regulation of protein kinase B signaling', 'protein destabilization', 'protein homooligomerization', 'sensory perception of pain', 'signal transduction']
Potassium voltage-gated channel, Shaw-related subfamily, member 1
104
Potassium voltage-gated channel, Shaw-related subfamily, member 1
83
4.7
73
0.29
Q3KNS8Q3KNS8['protein homooligomerization', 'regulation of ion transmembrane transport']['protein homooligomerization', 'regulation of ion transmembrane transport']
Cation channel sperm-associated auxiliary subunit delta
384
Cation channel sperm-associated auxiliary subunit epsilon
680
9.0
74
0.15
E9Q9F6P0DP43['flagellated sperm motility', 'sperm capacitation', 'spermatogenesis']['flagellated sperm motility', 'sperm capacitation']
Glycoprotein hormones alpha chain
83
Choriogonadotropin subunit beta 3
110
8.9
76
0.15
P01215P0DN86['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['apoptotic process', 'cell-cell signaling', 'female gamete generation', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'signal transduction']
Dynactin subunit 6
128
Dynactin subunit 5
114
8.9
84
0.13
D0G6S1A0A286ZK88['mitotic spindle organization']['aorta development', 'coronary vasculature development', 'ventricular septum development']
Glutamate receptor 1
603
Glutamate receptor 1
603
9.8
82
0.12
P19490P19490['cellular response to amine stimulus', 'cellular response to amino acid stimulus', 'cellular response to ammonium ion', 'cellular response to dsRNA', 'cellular response to growth factor stimulus', 'cellular response to organic cyclic compound', 'cellular response to peptide hormone stimulus', 'chemical synaptic transmission', 'long-term memory', 'long-term synaptic depression', 'modulation of chemical synaptic transmission', 'neuronal action potential', 'positive regulation of membrane potential', 'positive regulation of synaptic transmission', 'receptor internalization', 'regulation of postsynaptic membrane potential', 'regulation of receptor recycling', 'regulation of synaptic plasticity', 'response to arsenic-containing substance', 'response to cocaine', 'response to electrical stimulus', 'response to estradiol', 'response to fungicide', 'response to lithium ion', 'response to organic cyclic compound', 'response to peptide hormone', 'response to toxic substance', 'response to xenobiotic stimulus', 'spinal cord development', 'synaptic transmission, glutamatergic']['cellular response to amine stimulus', 'cellular response to amino acid stimulus', 'cellular response to ammonium ion', 'cellular response to dsRNA', 'cellular response to growth factor stimulus', 'cellular response to organic cyclic compound', 'cellular response to peptide hormone stimulus', 'chemical synaptic transmission', 'long-term memory', 'long-term synaptic depression', 'modulation of chemical synaptic transmission', 'neuronal action potential', 'positive regulation of membrane potential', 'positive regulation of synaptic transmission', 'receptor internalization', 'regulation of postsynaptic membrane potential', 'regulation of receptor recycling', 'regulation of synaptic plasticity', 'response to arsenic-containing substance', 'response to cocaine', 'response to electrical stimulus', 'response to estradiol', 'response to fungicide', 'response to lithium ion', 'response to organic cyclic compound', 'response to peptide hormone', 'response to toxic substance', 'response to xenobiotic stimulus', 'spinal cord development', 'synaptic transmission, glutamatergic']
Mitochondrial import receptor subunit TOM40 homolog
354
Mitochondrial import receptor subunit TOM40 homolog
354
4.8
88
0.24
O96008O96008['ion transport', 'protein import into mitochondrial matrix', 'protein insertion into mitochondrial outer membrane', 'protein targeting to mitochondrion']['ion transport', 'protein import into mitochondrial matrix', 'protein insertion into mitochondrial outer membrane', 'protein targeting to mitochondrion']
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
Cannabinoid receptor 2
134
3.7
80
0.34
P63096P34972['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell cycle', 'cell division', 'cellular response to forskolin', 'G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to cell cortex', 'regulation of cAMP-mediated signaling', 'regulation of mitotic spindle organization', 'response to peptide hormone']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'cannabinoid signaling pathway', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'immune response', 'inflammatory response', 'leukocyte chemotaxis', 'negative regulation of action potential', 'negative regulation of inflammatory response', 'negative regulation of mast cell activation', 'negative regulation of nitric-oxide synthase activity', 'negative regulation of synaptic transmission, GABAergic', 'regulation of metabolic process', 'response to amphetamine', 'response to lipopolysaccharide', 'sensory perception of pain']
Angiotensin-converting enzyme 2
141
Angiotensin-converting enzyme 2
133
7.8
45
0.29
Q9BYF1Q9BYF1['angiotensin maturation', 'angiotensin-mediated drinking behavior', 'blood vessel diameter maintenance', 'maternal process involved in female pregnancy', 'membrane fusion', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of signaling receptor activity', 'negative regulation of smooth muscle cell proliferation', 'positive regulation of amino acid transport', 'positive regulation of cardiac muscle contraction', 'positive regulation of gap junction assembly', 'positive regulation of L-proline import across plasma membrane', 'positive regulation of reactive oxygen species metabolic process', 'receptor-mediated endocytosis of virus by host cell', 'receptor-mediated virion attachment to host cell', 'regulation of cardiac conduction', 'regulation of cell population proliferation', 'regulation of cytokine production', 'regulation of inflammatory response', 'regulation of systemic arterial blood pressure by renin-angiotensin', 'regulation of transmembrane transporter activity', 'regulation of vasoconstriction', 'tryptophan transport', 'viral entry into host cell', 'viral life cycle']['angiotensin maturation', 'angiotensin-mediated drinking behavior', 'blood vessel diameter maintenance', 'maternal process involved in female pregnancy', 'membrane fusion', 'negative regulation of ERK1 and ERK2 cascade', 'negative regulation of signaling receptor activity', 'negative regulation of smooth muscle cell proliferation', 'positive regulation of amino acid transport', 'positive regulation of cardiac muscle contraction', 'positive regulation of gap junction assembly', 'positive regulation of L-proline import across plasma membrane', 'positive regulation of reactive oxygen species metabolic process', 'receptor-mediated endocytosis of virus by host cell', 'receptor-mediated virion attachment to host cell', 'regulation of cardiac conduction', 'regulation of cell population proliferation', 'regulation of cytokine production', 'regulation of inflammatory response', 'regulation of systemic arterial blood pressure by renin-angiotensin', 'regulation of transmembrane transporter activity', 'regulation of vasoconstriction', 'tryptophan transport', 'viral entry into host cell', 'viral life cycle']
Proteasome subunit beta type-3
129
Proteasome subunit beta type-10
70
6.4
71
0.22
P33672Q3T0T1['proteasomal protein catabolic process', 'proteasome-mediated ubiquitin-dependent protein catabolic process']['immune system process', 'proteasomal protein catabolic process']
Mas-related G-protein coupled receptor member X2
168
Cortistatin
93
5.7
57
0.31
Q96LB1O00230['G protein-coupled receptor signaling pathway', 'mast cell activation', 'mast cell degranulation', 'positive regulation of cytokinesis', 'sensory perception of pain', 'sleep']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'chemical synaptic transmission', 'replication fork processing', 'resolution of meiotic recombination intermediates']
Insulin-like growth factor 1 receptor
703
Insulin-like growth factor 1 receptor
703
9.4
31
0.34
Q60751Q60751['adrenal gland development', 'amyloid-beta clearance', 'animal organ morphogenesis', 'axonogenesis', 'brain development', 'cellular response to amyloid-beta', 'cellular response to glucose stimulus', 'cellular response to insulin stimulus', 'cellular response to insulin-like growth factor stimulus', 'cellular response to transforming growth factor beta stimulus', 'cerebellum development', 'dendritic spine maintenance', 'epidermis development', 'establishment of cell polarity', 'estrous cycle', 'exocrine pancreas development', 'glucose homeostasis', 'immune response', 'insulin receptor signaling pathway', 'insulin-like growth factor receptor signaling pathway', 'male sex determination', 'mammary gland development', 'MAPK cascade', 'mitotic nuclear division', 'negative regulation of apoptotic process', 'negative regulation of cholangiocyte apoptotic process', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of hepatocyte apoptotic process', 'negative regulation of MAPK cascade', 'negative regulation of muscle cell apoptotic process', 'negative regulation of protein kinase B signaling', 'neuron projection development', 'peptidyl-tyrosine autophosphorylation', 'phosphatidylinositol-mediated signaling', 'positive regulation of axon regeneration', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cold-induced thermogenesis', 'positive regulation of cytokinesis', 'positive regulation of developmental growth', 'positive regulation of DNA metabolic process', 'positive regulation of kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of osteoblast proliferation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein-containing complex disassembly', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of steroid hormone biosynthetic process', 'positive regulation of transcription, DNA-templated', 'prostate gland epithelium morphogenesis', 'protein autophosphorylation', 'protein kinase B signaling', 'protein phosphorylation', 'regulation of JNK cascade', 'response to ethanol', 'response to L-glutamate', 'transcytosis', 'transmembrane receptor protein tyrosine kinase signaling pathway']['adrenal gland development', 'amyloid-beta clearance', 'animal organ morphogenesis', 'axonogenesis', 'brain development', 'cellular response to amyloid-beta', 'cellular response to glucose stimulus', 'cellular response to insulin stimulus', 'cellular response to insulin-like growth factor stimulus', 'cellular response to transforming growth factor beta stimulus', 'cerebellum development', 'dendritic spine maintenance', 'epidermis development', 'establishment of cell polarity', 'estrous cycle', 'exocrine pancreas development', 'glucose homeostasis', 'immune response', 'insulin receptor signaling pathway', 'insulin-like growth factor receptor signaling pathway', 'male sex determination', 'mammary gland development', 'MAPK cascade', 'mitotic nuclear division', 'negative regulation of apoptotic process', 'negative regulation of cholangiocyte apoptotic process', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of hepatocyte apoptotic process', 'negative regulation of MAPK cascade', 'negative regulation of muscle cell apoptotic process', 'negative regulation of protein kinase B signaling', 'neuron projection development', 'peptidyl-tyrosine autophosphorylation', 'phosphatidylinositol-mediated signaling', 'positive regulation of axon regeneration', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cold-induced thermogenesis', 'positive regulation of cytokinesis', 'positive regulation of developmental growth', 'positive regulation of DNA metabolic process', 'positive regulation of kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of osteoblast proliferation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein-containing complex disassembly', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of steroid hormone biosynthetic process', 'positive regulation of transcription, DNA-templated', 'prostate gland epithelium morphogenesis', 'protein autophosphorylation', 'protein kinase B signaling', 'protein phosphorylation', 'regulation of JNK cascade', 'response to ethanol', 'response to L-glutamate', 'transcytosis', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Glutamate receptor 1
323
Glutamate receptor
78
8.8
73
0.16
P23818G5E8H1['cellular response to ammonium ion', 'chemical synaptic transmission', 'long-term memory', 'long-term synaptic depression', 'modulation of chemical synaptic transmission', 'neuronal action potential', 'positive regulation of membrane potential', 'positive regulation of synaptic transmission', 'receptor internalization', 'regulation of postsynaptic membrane potential', 'regulation of receptor recycling', 'regulation of synaptic plasticity', 'response to toxic substance'][]
Beta-2-microglobulin
100
Beta-2-microglobulin
100
4.8
65
0.32
P61769P61769['amyloid fibril formation', 'antibacterial humoral response', 'antigen processing and presentation of endogenous peptide antigen via MHC class I', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to iron ion', 'cellular response to iron(III) ion', 'cellular response to lipopolysaccharide', 'cellular response to nicotine', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'iron ion homeostasis', 'iron ion transport', 'learning or memory', 'negative regulation of epithelial cell proliferation', 'negative regulation of forebrain neuron differentiation', 'negative regulation of neurogenesis', 'negative regulation of neuron projection development', 'negative regulation of receptor binding', 'peptide antigen assembly with MHC class II protein complex', 'positive regulation of cellular senescence', 'positive regulation of ferrous iron binding', 'positive regulation of protein binding', 'positive regulation of receptor binding', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of T cell activation', 'positive regulation of T cell cytokine production', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of transferrin receptor binding', 'protein homotetramerization', 'protein refolding', 'regulation of erythrocyte differentiation', 'regulation of iron ion transport', 'regulation of membrane depolarization', 'response to molecule of bacterial origin', 'retina homeostasis', 'sensory perception of smell', 'T cell differentiation in thymus', 'T cell mediated cytotoxicity']['amyloid fibril formation', 'antibacterial humoral response', 'antigen processing and presentation of endogenous peptide antigen via MHC class I', 'antigen processing and presentation of exogenous peptide antigen via MHC class II', 'antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular response to iron ion', 'cellular response to iron(III) ion', 'cellular response to lipopolysaccharide', 'cellular response to nicotine', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'innate immune response', 'iron ion homeostasis', 'iron ion transport', 'learning or memory', 'negative regulation of epithelial cell proliferation', 'negative regulation of forebrain neuron differentiation', 'negative regulation of neurogenesis', 'negative regulation of neuron projection development', 'negative regulation of receptor binding', 'peptide antigen assembly with MHC class II protein complex', 'positive regulation of cellular senescence', 'positive regulation of ferrous iron binding', 'positive regulation of protein binding', 'positive regulation of receptor binding', 'positive regulation of receptor-mediated endocytosis', 'positive regulation of T cell activation', 'positive regulation of T cell cytokine production', 'positive regulation of T cell mediated cytotoxicity', 'positive regulation of transferrin receptor binding', 'protein homotetramerization', 'protein refolding', 'regulation of erythrocyte differentiation', 'regulation of iron ion transport', 'regulation of membrane depolarization', 'response to molecule of bacterial origin', 'retina homeostasis', 'sensory perception of smell', 'T cell differentiation in thymus', 'T cell mediated cytotoxicity']
Insulin receptor
712
Insulin receptor
711
7.1
nan
nan
P15208P15208['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'animal organ morphogenesis', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'male gonad development', 'male sex determination', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of protein phosphorylation', 'negative regulation of transporter activity', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of hydrogen peroxide metabolic process', 'regulation of transcription, DNA-templated', 'response to nutrient levels', 'response to tumor necrosis factor', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'viral entry into host cell']['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'animal organ morphogenesis', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'male gonad development', 'male sex determination', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of protein phosphorylation', 'negative regulation of transporter activity', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of hydrogen peroxide metabolic process', 'regulation of transcription, DNA-templated', 'response to nutrient levels', 'response to tumor necrosis factor', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'viral entry into host cell']
Tropomyosin alpha-1 chain
190
Tropomyosin alpha-1 chain
190
4.8
55
0.38
1
✔P09493P09493['actin filament organization', 'cardiac muscle contraction', 'cellular response to reactive oxygen species', 'cytoskeleton organization', 'muscle contraction', 'muscle filament sliding', 'negative regulation of cell migration', 'negative regulation of vascular associated smooth muscle cell migration', 'negative regulation of vascular associated smooth muscle cell proliferation', 'positive regulation of ATP-dependent activity', 'positive regulation of cell adhesion', 'positive regulation of heart rate by epinephrine', 'positive regulation of stress fiber assembly', 'regulation of cell shape', 'regulation of heart contraction', 'regulation of muscle contraction', 'ruffle organization', 'sarcomere organization', 'ventricular cardiac muscle tissue morphogenesis', 'wound healing']['actin filament organization', 'cardiac muscle contraction', 'cellular response to reactive oxygen species', 'cytoskeleton organization', 'muscle contraction', 'muscle filament sliding', 'negative regulation of cell migration', 'negative regulation of vascular associated smooth muscle cell migration', 'negative regulation of vascular associated smooth muscle cell proliferation', 'positive regulation of ATP-dependent activity', 'positive regulation of cell adhesion', 'positive regulation of heart rate by epinephrine', 'positive regulation of stress fiber assembly', 'regulation of cell shape', 'regulation of heart contraction', 'regulation of muscle contraction', 'ruffle organization', 'sarcomere organization', 'ventricular cardiac muscle tissue morphogenesis', 'wound healing']
von Willebrand factor
1101
von Willebrand factor
1097
7.7
77
0.17
P04275P04275['blood coagulation', 'cell adhesion', 'cell-substrate adhesion', 'hemostasis', 'platelet activation', 'positive regulation of intracellular signal transduction', 'response to wounding']['blood coagulation', 'cell adhesion', 'cell-substrate adhesion', 'hemostasis', 'platelet activation', 'positive regulation of intracellular signal transduction', 'response to wounding']
Sodium channel protein type 9 subunit alpha
895
Sodium channel subunit beta-2
55
2.0
70
0.71
Q15858O60939['behavioral response to formalin induced pain', 'inflammatory response', 'membrane depolarization during action potential', 'negative regulation of action potential', 'neuronal action potential', 'post-embryonic development', 'regulation of ion transmembrane transport', 'response to cold', 'response to heat', 'response to toxic substance', 'sensory perception of pain', 'sodium ion transmembrane transport', 'sodium ion transport']['cardiac muscle cell action potential involved in contraction', 'cardiac muscle contraction', 'chemical synaptic transmission', 'gene expression', 'membrane depolarization during cardiac muscle cell action potential', 'nervous system development', 'regulation of atrial cardiac muscle cell membrane depolarization', 'regulation of heart rate by cardiac conduction', 'regulation of sodium ion transmembrane transporter activity', 'response to heat', 'response to pyrethroid', 'sodium ion transmembrane transport']
Igh protein
249
Igh protein
249
9.8
nan
nan
Q99M22Q99M22[][]
Glycoprotein hormones alpha chain
55
Thyrotropin subunit beta
72
8.8
81
0.14
P01215P01222['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['anatomical structure morphogenesis', 'cell-cell signaling', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'response to calcium ion', 'response to estrogen', 'response to vitamin A']
C-C motif chemokine 20
33
C-C chemokine receptor type 6
288
9.8
64
0.16
P78556P51684['antimicrobial humoral immune response mediated by antimicrobial peptide', 'calcium-mediated signaling using intracellular calcium source', 'cell chemotaxis', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response to bacterium', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of T cell migration', 'signal transduction', 'T cell migration', 'thymocyte migration']['calcium-mediated signaling', 'cell chemotaxis', 'cellular defense response', 'chemotaxis', 'dendritic cell chemotaxis', 'DN2 thymocyte differentiation', 'DN3 thymocyte differentiation', 'humoral immune response', 'immune response', 'isotype switching to IgA isotypes', 'leukocyte migration involved in inflammatory response', 'lymphocyte migration', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of dendritic cell chemotaxis', 'positive regulation of flagellated sperm motility involved in capacitation', 'regulation of T cell migration', 'signal transduction', 'T cell migration', 'thymocyte migration']
Gap junction gamma-3 protein
2
Gap junction gamma-3 protein
2
6.0
nan
nan
Q8NFK1Q8NFK1['cell-cell signaling', 'myelination', 'sensory perception of sound']['cell-cell signaling', 'myelination', 'sensory perception of sound']
Protein kinase, cAMP dependent regulatory, type II alpha
99
cAMP-dependent protein kinase catalytic subunit alpha
200
5.1
69
0.29
Q8K1M3P05132['phosphorylation']['cellular response to cold', 'cellular response to glucose stimulus', 'cellular response to heat', 'cellular response to parathyroid hormone stimulus', 'mesoderm formation', 'modulation of chemical synaptic transmission', 'mRNA processing', 'negative regulation of meiotic cell cycle', 'negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning', 'neural tube closure', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of cell population proliferation', 'positive regulation of protein export from nucleus', 'protein autophosphorylation', 'protein export from nucleus', 'protein kinase A signaling', 'protein localization to lipid droplet', 'protein phosphorylation', 'regulation of bicellular tight junction assembly', 'regulation of cell cycle', 'regulation of cellular respiration', 'regulation of osteoblast differentiation', 'regulation of proteasomal protein catabolic process', 'regulation of protein processing', 'regulation of synaptic transmission, glutamatergic', 'sperm capacitation', 'spontaneous exocytosis of neurotransmitter']
Immunoglobulin heavy constant alpha 2
110
Immunoglobulin heavy constant alpha 2
110
9.9
nan
nan
P01877P01877['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']
Glycoprotein hormones alpha chain
111
Choriogonadotropin subunit beta 3
110
10.0
75
0.13
P01215P0DN86['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['apoptotic process', 'cell-cell signaling', 'female gamete generation', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'signal transduction']
Extracellular calcium-sensing receptor
131
Extracellular calcium-sensing receptor
131
3.7
nan
nan
P41180P41180['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'anatomical structure morphogenesis', 'apoptotic process', 'bile acid secretion', 'branching morphogenesis of an epithelial tube', 'calcium ion import', 'cellular calcium ion homeostasis', 'cellular response to glucose stimulus', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to hypoxia', 'cellular response to low-density lipoprotein particle stimulus', 'cellular response to peptide', 'cellular response to vitamin D', 'chemosensory behavior', 'chloride transmembrane transport', 'detection of calcium ion', 'fat pad development', 'G protein-coupled receptor signaling pathway', 'JNK cascade', 'ossification', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of ATP-dependent activity', 'positive regulation of calcium ion import', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of insulin secretion', 'positive regulation of positive chemotaxis', 'positive regulation of vasoconstriction', 'regulation of calcium ion transport', 'response to fibroblast growth factor', 'response to ischemia', 'vasodilation']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'anatomical structure morphogenesis', 'apoptotic process', 'bile acid secretion', 'branching morphogenesis of an epithelial tube', 'calcium ion import', 'cellular calcium ion homeostasis', 'cellular response to glucose stimulus', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to hypoxia', 'cellular response to low-density lipoprotein particle stimulus', 'cellular response to peptide', 'cellular response to vitamin D', 'chemosensory behavior', 'chloride transmembrane transport', 'detection of calcium ion', 'fat pad development', 'G protein-coupled receptor signaling pathway', 'JNK cascade', 'ossification', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of ATP-dependent activity', 'positive regulation of calcium ion import', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of gene expression', 'positive regulation of insulin secretion', 'positive regulation of positive chemotaxis', 'positive regulation of vasoconstriction', 'regulation of calcium ion transport', 'response to fibroblast growth factor', 'response to ischemia', 'vasodilation']
Insulin receptor
674
Insulin receptor
911
9.8
59
0.17
P06213P06213['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell']['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell']
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
245
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
72
8.9
85
0.13
P46977P61803['co-translational protein modification', 'post-translational protein modification', 'protein N-linked glycosylation', 'protein N-linked glycosylation via asparagine']['apoptotic process', 'blastocyst development', 'negative regulation of apoptotic process', 'protein glycosylation', 'protein N-linked glycosylation', 'protein N-linked glycosylation via asparagine', 'regulation of protein stability', 'response to nutrient', 'response to xenobiotic stimulus']
Insulin-like growth factor 1 receptor
701
Insulin-like growth factor 1 receptor
701
2.0
nan
nan
Q60751Q60751['adrenal gland development', 'amyloid-beta clearance', 'animal organ morphogenesis', 'axonogenesis', 'brain development', 'cellular response to amyloid-beta', 'cellular response to glucose stimulus', 'cellular response to insulin stimulus', 'cellular response to insulin-like growth factor stimulus', 'cellular response to transforming growth factor beta stimulus', 'cerebellum development', 'dendritic spine maintenance', 'epidermis development', 'establishment of cell polarity', 'estrous cycle', 'exocrine pancreas development', 'glucose homeostasis', 'immune response', 'insulin receptor signaling pathway', 'insulin-like growth factor receptor signaling pathway', 'male sex determination', 'mammary gland development', 'MAPK cascade', 'mitotic nuclear division', 'negative regulation of apoptotic process', 'negative regulation of cholangiocyte apoptotic process', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of hepatocyte apoptotic process', 'negative regulation of MAPK cascade', 'negative regulation of muscle cell apoptotic process', 'negative regulation of protein kinase B signaling', 'neuron projection development', 'peptidyl-tyrosine autophosphorylation', 'phosphatidylinositol-mediated signaling', 'positive regulation of axon regeneration', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cold-induced thermogenesis', 'positive regulation of cytokinesis', 'positive regulation of developmental growth', 'positive regulation of DNA metabolic process', 'positive regulation of kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of osteoblast proliferation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein-containing complex disassembly', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of steroid hormone biosynthetic process', 'positive regulation of transcription, DNA-templated', 'prostate gland epithelium morphogenesis', 'protein autophosphorylation', 'protein kinase B signaling', 'protein phosphorylation', 'regulation of JNK cascade', 'response to ethanol', 'response to L-glutamate', 'transcytosis', 'transmembrane receptor protein tyrosine kinase signaling pathway']['adrenal gland development', 'amyloid-beta clearance', 'animal organ morphogenesis', 'axonogenesis', 'brain development', 'cellular response to amyloid-beta', 'cellular response to glucose stimulus', 'cellular response to insulin stimulus', 'cellular response to insulin-like growth factor stimulus', 'cellular response to transforming growth factor beta stimulus', 'cerebellum development', 'dendritic spine maintenance', 'epidermis development', 'establishment of cell polarity', 'estrous cycle', 'exocrine pancreas development', 'glucose homeostasis', 'immune response', 'insulin receptor signaling pathway', 'insulin-like growth factor receptor signaling pathway', 'male sex determination', 'mammary gland development', 'MAPK cascade', 'mitotic nuclear division', 'negative regulation of apoptotic process', 'negative regulation of cholangiocyte apoptotic process', 'negative regulation of DNA-binding transcription factor activity', 'negative regulation of hepatocyte apoptotic process', 'negative regulation of MAPK cascade', 'negative regulation of muscle cell apoptotic process', 'negative regulation of protein kinase B signaling', 'neuron projection development', 'peptidyl-tyrosine autophosphorylation', 'phosphatidylinositol-mediated signaling', 'positive regulation of axon regeneration', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cold-induced thermogenesis', 'positive regulation of cytokinesis', 'positive regulation of developmental growth', 'positive regulation of DNA metabolic process', 'positive regulation of kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of osteoblast proliferation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein-containing complex disassembly', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of steroid hormone biosynthetic process', 'positive regulation of transcription, DNA-templated', 'prostate gland epithelium morphogenesis', 'protein autophosphorylation', 'protein kinase B signaling', 'protein phosphorylation', 'regulation of JNK cascade', 'response to ethanol', 'response to L-glutamate', 'transcytosis', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Immunoglobulin heavy constant alpha 1
123
Immunoglobulin heavy constant alpha 1
123
9.2
nan
nan
P01876P01876['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']
Two pore channel protein 2
228
Two pore channel protein 2
450
8.1
59
0.21
Q8NHX9Q8NHX9['calcium-mediated signaling', 'cellular calcium ion homeostasis', 'endocytosis involved in viral entry into host cell', 'endosome to lysosome transport of low-density lipoprotein particle', 'ion transmembrane transport', 'lysosome organization', 'receptor-mediated endocytosis of virus by host cell', 'regulation of autophagy', 'regulation of exocytosis', 'regulation of ion transmembrane transport', 'response to vitamin D', 'smooth muscle contraction', 'sodium ion transmembrane transport']['calcium-mediated signaling', 'cellular calcium ion homeostasis', 'endocytosis involved in viral entry into host cell', 'endosome to lysosome transport of low-density lipoprotein particle', 'ion transmembrane transport', 'lysosome organization', 'receptor-mediated endocytosis of virus by host cell', 'regulation of autophagy', 'regulation of exocytosis', 'regulation of ion transmembrane transport', 'response to vitamin D', 'smooth muscle contraction', 'sodium ion transmembrane transport']
Exosome complex component RRP46
138
Exosome complex component RRP40
83
9.8
99
0.1
Q9NQT4Q9NQT5['defense response to virus', 'DNA deamination', 'exonucleolytic catabolism of deadenylated mRNA', 'nuclear mRNA surveillance', "nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'", "polyadenylation-dependent snoRNA 3'-end processing", 'RNA catabolic process', 'RNA processing', 'rRNA catabolic process', 'rRNA processing', "U4 snRNA 3'-end processing"]['CUT catabolic process', 'DNA deamination', 'exonucleolytic catabolism of deadenylated mRNA', "exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", 'isotype switching', 'nuclear polyadenylation-dependent rRNA catabolic process', 'nuclear polyadenylation-dependent tRNA catabolic process', "nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'", "polyadenylation-dependent snoRNA 3'-end processing", 'positive regulation of isotype switching', 'RNA catabolic process', 'RNA processing', 'rRNA processing', "U4 snRNA 3'-end processing"]
Sodium channel protein type 7 subunit alpha
927
Sodium channel subunit beta-3
180
9.8
57
0.18
Q01118Q9NY72['cellular homeostasis', 'membrane depolarization during action potential', 'muscle contraction', 'neuronal action potential', 'regulation of ion transmembrane transport', 'response to bacterium', 'sodium ion homeostasis', 'sodium ion transmembrane transport', 'sodium ion transport']['atrial cardiac muscle cell action potential', 'cardiac muscle cell action potential involved in contraction', 'cardiac muscle contraction', 'membrane depolarization', 'membrane depolarization during action potential', 'membrane depolarization during cardiac muscle cell action potential', 'nervous system development', 'positive regulation of heart rate', 'positive regulation of sodium ion transport', 'protein localization to plasma membrane', 'regulation of atrial cardiac muscle cell membrane depolarization', 'regulation of heart rate by cardiac conduction', 'regulation of sodium ion transmembrane transporter activity', 'regulation of ventricular cardiac muscle cell membrane depolarization', 'SA node cell action potential', 'sensory perception of pain', 'sodium ion transmembrane transport', 'sodium ion transport', 'ventricular cardiac muscle cell action potential']
Immunoglobulin heavy constant alpha 1
123
Immunoglobulin heavy constant alpha 1
122
8.3
nan
nan
P01876P01876['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']
Cysteine desulfurase, mitochondrial
308
Frataxin, mitochondrial
50
10.0
88
0.11
Q9Y697Q16595['[2Fe-2S] cluster assembly', 'iron incorporation into metallo-sulfur cluster', 'iron-sulfur cluster assembly', 'Mo-molybdopterin cofactor biosynthetic process']['adult walking behavior', 'cellular iron ion homeostasis', 'cellular response to hydrogen peroxide', 'embryo development ending in birth or egg hatching', 'heme biosynthetic process', 'ion transport', 'iron incorporation into metallo-sulfur cluster', 'iron-sulfur cluster assembly', 'mitochondrion organization', 'muscle cell cellular homeostasis', 'negative regulation of apoptotic process', 'negative regulation of multicellular organism growth', 'negative regulation of organ growth', 'negative regulation of release of cytochrome c from mitochondria', 'organ growth', 'oxidative phosphorylation', 'positive regulation of aconitate hydratase activity', 'positive regulation of catalytic activity', 'positive regulation of cell growth', 'positive regulation of cell population proliferation', 'positive regulation of lyase activity', 'positive regulation of succinate dehydrogenase activity', 'proprioception', 'protein autoprocessing', 'regulation of ferrochelatase activity', 'response to iron ion']
N-formyl peptide receptor 2
63
Guanine nucleotide-binding protein G(i) subunit alpha-2
352
8.8
79
0.14
P25090P04899['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'astrocyte activation', 'calcium-mediated signaling', 'cell adhesion', 'cell surface receptor signaling pathway', 'cellular response to amyloid-beta', 'chemotaxis', 'complement receptor mediated signaling pathway', 'defense response to bacterium', 'G protein-coupled receptor signaling pathway', 'immune response-regulating cell surface receptor signaling pathway', 'inflammatory response', 'microglial cell activation', 'negative regulation of inflammatory response', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive chemotaxis', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of innate immune response', 'positive regulation of monocyte chemotaxis', 'positive regulation of phagocytosis', 'positive regulation of protein phosphorylation', 'positive regulation of superoxide anion generation', 'receptor-mediated endocytosis']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell cycle', 'cell division', 'cell population proliferation', 'G protein-coupled acetylcholine receptor signaling pathway', 'G protein-coupled adenosine receptor signaling pathway', 'G protein-coupled receptor signaling pathway', 'gamma-aminobutyric acid signaling pathway', 'negative regulation of adenylate cyclase activity', 'negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process', 'negative regulation of apoptotic signaling pathway', 'negative regulation of calcium ion-dependent exocytosis', 'negative regulation of protein tyrosine phosphatase activity', 'negative regulation of synaptic transmission', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of NAD(P)H oxidase activity', 'positive regulation of neural precursor cell proliferation', 'positive regulation of renal sodium excretion', 'positive regulation of superoxide anion generation', 'positive regulation of urine volume', 'positive regulation of vascular associated smooth muscle cell proliferation', 'regulation of calcium ion transport', 'response to nutrient', 'signal transduction']
DNA-directed RNA polymerase I subunit RPA1
968
DNA-directed RNA polymerase I subunit RPA2
498
7.7
92
0.14
O95602Q9H9Y6['negative regulation of protein localization to nucleolus']['embryo implantation', 'neural crest formation', 'nucleologenesis', 'rRNA transcription']
C-C motif chemokine 15
54
C-C chemokine receptor type 1
24
7.7
64
0.2
Q16663P32246['cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'signal transduction']['calcium ion transport', 'calcium-mediated signaling', 'cell adhesion', 'cell chemotaxis', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'dendritic cell chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'immune response', 'inflammatory response', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'positive regulation of calcium ion transport', 'positive regulation of cell migration', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of monocyte chemotaxis', 'positive regulation of osteoclast differentiation', 'response to wounding']
Isoform 3 of Metabotropic glutamate receptor 7
136
Isoform 3 of Metabotropic glutamate receptor 7
136
2.0
nan
nan
Q14831-3Q14831-3[][]
Insulin-like growth factor 1 receptor
700
Insulin-like growth factor 1 receptor
700
2.0
nan
nan
P08069P08069['aging', 'amyloid-beta clearance', 'axonogenesis', 'cardiac atrium development', 'cellular response to aldosterone', 'cellular response to amyloid-beta', 'cellular response to angiotensin', 'cellular response to dexamethasone stimulus', 'cellular response to estradiol stimulus', 'cellular response to glucose stimulus', 'cellular response to insulin-like growth factor stimulus', 'cellular response to mechanical stimulus', 'cellular response to progesterone stimulus', 'cellular response to testosterone stimulus', 'cellular response to transforming growth factor beta stimulus', 'cellular senescence', 'cerebellum development', 'dendritic spine maintenance', 'establishment of cell polarity', 'estrous cycle', 'glucose homeostasis', 'hippocampus development', 'immune response', 'insulin receptor signaling pathway', 'insulin-like growth factor receptor signaling pathway', 'negative regulation of apoptotic process', 'negative regulation of cholangiocyte apoptotic process', 'negative regulation of hepatocyte apoptotic process', 'negative regulation of MAPK cascade', 'negative regulation of muscle cell apoptotic process', 'peptidyl-tyrosine autophosphorylation', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol-mediated signaling', 'positive regulation of axon regeneration', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cold-induced thermogenesis', 'positive regulation of cytokinesis', 'positive regulation of DNA metabolic process', 'positive regulation of kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of osteoblast proliferation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein-containing complex disassembly', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of steroid hormone biosynthetic process', 'protein autophosphorylation', 'regulation of JNK cascade', 'response to ethanol', 'response to L-glutamate', 'response to nicotine', 'response to vitamin E', 'signal transduction', 'transcytosis', 'transmembrane receptor protein tyrosine kinase signaling pathway']['aging', 'amyloid-beta clearance', 'axonogenesis', 'cardiac atrium development', 'cellular response to aldosterone', 'cellular response to amyloid-beta', 'cellular response to angiotensin', 'cellular response to dexamethasone stimulus', 'cellular response to estradiol stimulus', 'cellular response to glucose stimulus', 'cellular response to insulin-like growth factor stimulus', 'cellular response to mechanical stimulus', 'cellular response to progesterone stimulus', 'cellular response to testosterone stimulus', 'cellular response to transforming growth factor beta stimulus', 'cellular senescence', 'cerebellum development', 'dendritic spine maintenance', 'establishment of cell polarity', 'estrous cycle', 'glucose homeostasis', 'hippocampus development', 'immune response', 'insulin receptor signaling pathway', 'insulin-like growth factor receptor signaling pathway', 'negative regulation of apoptotic process', 'negative regulation of cholangiocyte apoptotic process', 'negative regulation of hepatocyte apoptotic process', 'negative regulation of MAPK cascade', 'negative regulation of muscle cell apoptotic process', 'peptidyl-tyrosine autophosphorylation', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol-mediated signaling', 'positive regulation of axon regeneration', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cold-induced thermogenesis', 'positive regulation of cytokinesis', 'positive regulation of DNA metabolic process', 'positive regulation of kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of osteoblast proliferation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein-containing complex disassembly', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of steroid hormone biosynthetic process', 'protein autophosphorylation', 'regulation of JNK cascade', 'response to ethanol', 'response to L-glutamate', 'response to nicotine', 'response to vitamin E', 'signal transduction', 'transcytosis', 'transmembrane receptor protein tyrosine kinase signaling pathway']
C-C motif chemokine 15
93
C-C chemokine receptor type 1
24
10.0
71
0.14
Q16663P32246['cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'signal transduction']['calcium ion transport', 'calcium-mediated signaling', 'cell adhesion', 'cell chemotaxis', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'dendritic cell chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'immune response', 'inflammatory response', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'positive regulation of calcium ion transport', 'positive regulation of cell migration', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of monocyte chemotaxis', 'positive regulation of osteoclast differentiation', 'response to wounding']
RuvB-like 1
206
Actin-related protein 6
339
8.1
57
0.22
Q9Y265Q9GZN1['box C/D snoRNP assembly', 'cell cycle', 'cell division', 'chromatin remodeling', 'DNA recombination', 'DNA repair', 'histone acetylation', 'histone exchange', 'histone H2A acetylation', 'histone H4 acetylation', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of double-strand break repair via homologous recombination', 'positive regulation of telomerase RNA localization to Cajal body', 'positive regulation of telomere maintenance in response to DNA damage', 'positive regulation of transcription, DNA-templated', 'protein stabilization', 'regulation of apoptotic process', 'regulation of cell cycle', 'regulation of chromosome organization', 'regulation of DNA replication', 'regulation of DNA strand elongation', 'regulation of double-strand break repair', 'regulation of embryonic development', 'regulation of growth', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'spermatogenesis', 'telomere maintenance']['histone exchange', 'negative regulation of transcription by RNA polymerase I', 'nucleolus organization', 'positive regulation of transcription by RNA polymerase I', 'regulation of transcription, DNA-templated']
DNA-directed RNA polymerase II subunit RPB1
1430
DNA-directed RNA polymerase II subunit RPB2
1155
9.8
82
0.12
P24928P30876['DNA-templated transcription, termination', 'positive regulation of RNA splicing', 'regulation of transcription, DNA-templated', 'transcription by RNA polymerase II']['transcription by RNA polymerase II']
Immunoglobulin J chain
37
Immunoglobulin heavy constant alpha 2
339
2.0
72
0.69
P01591P01877['adaptive immune response', 'antibacterial humoral response', 'glomerular filtration', 'humoral immune response', 'immune response', 'innate immune response', 'positive regulation of respiratory burst', 'protein-containing complex assembly', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']
LHFPL tetraspan subfamily member 5 protein
35
Protocadherin-15
1392
7.5
69
0.19
Q4KL25Q99PJ1['auditory receptor cell stereocilium organization', 'detection of mechanical stimulus involved in sensory perception', 'detection of mechanical stimulus involved in sensory perception of sound', 'ion transport', 'sensory perception of sound']['actin filament organization', 'adult walking behavior', 'auditory receptor cell stereocilium organization', 'cell adhesion', 'detection of mechanical stimulus involved in equilibrioception', 'detection of mechanical stimulus involved in sensory perception of sound', 'equilibrioception', 'homophilic cell adhesion via plasma membrane adhesion molecules', 'inner ear auditory receptor cell differentiation', 'inner ear development', 'inner ear receptor cell stereocilium organization', 'locomotory behavior', 'morphogenesis of an epithelium', 'multicellular organism growth', 'non-motile cilium assembly', 'photoreceptor cell maintenance', 'righting reflex', 'sensory perception of light stimulus', 'sensory perception of sound', 'startle response', 'visual perception']
Isoform 5 of Inosine-5'-monophosphate dehydrogenase 1
414
Isoform 5 of Inosine-5'-monophosphate dehydrogenase 1
543
9.3
94
0.11
P20839-5P20839-5[][]
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
141
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
155
4.1
77
0.32
Q8HXG5Q02373['mitochondrial respiratory chain complex I assembly']['mitochondrial respiratory chain complex I assembly']
Lys-63-specific deubiquitinase BRCC36
156
BRISC complex subunit Abraxas 2
14
9.8
83
0.12
P46736Q15018['cell division', 'cellular response to ionizing radiation', 'chromatin organization', 'double-strand break repair', 'histone H2A K63-linked deubiquitination', 'histone H2A monoubiquitination', 'mitotic G2 DNA damage checkpoint signaling', 'mitotic G2/M transition checkpoint', 'positive regulation of DNA repair', 'protein autoubiquitination', 'protein deubiquitination', 'protein K63-linked deubiquitination', 'regulation of DNA damage checkpoint', 'regulation of DNA repair', 'response to ionizing radiation', 'response to X-ray']['attachment of spindle microtubules to kinetochore', 'cell division', 'chromosome segregation', 'mitotic cell cycle', 'mitotic spindle assembly', 'protein K63-linked deubiquitination', 'response to ischemia']
General transcription factor IIH subunit 3
271
General transcription factor IIH subunit 2
247
8.4
78
0.15
Q13889Q13888['DNA repair', 'nucleotide-excision repair', 'phosphorylation of RNA polymerase II C-terminal domain', 'transcription by RNA polymerase II']['G protein-coupled receptor internalization', 'nucleotide-excision repair', 'positive regulation of DNA helicase activity', 'regulation of transcription by RNA polymerase II', 'response to UV', 'transcription by RNA polymerase II', 'transcription initiation from RNA polymerase II promoter']
DNA-directed RNA polymerase I subunit RPA2
93
DNA-directed RNA polymerases I, II, and III subunit RPABC4
39
9.3
47
0.23
Q9H9Y6P53803['embryo implantation', 'neural crest formation', 'nucleologenesis', 'rRNA transcription']['regulation of transcription by RNA polymerase I', 'transcription by RNA polymerase II', 'transcription by RNA polymerase III']
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
70
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
70
2.0
56
0.88
Q3T906Q3T906['carbohydrate phosphorylation', 'lysosome organization', 'N-glycan processing to lysosome', 'secretion of lysosomal enzymes']['carbohydrate phosphorylation', 'lysosome organization', 'N-glycan processing to lysosome', 'secretion of lysosomal enzymes']
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
225
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
7.5
99
0.14
P04394P25708['cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development']['mitochondrial electron transport, NADH to ubiquinone']
Immunoglobulin heavy constant alpha 1
352
Immunoglobulin J chain
35
9.3
65
0.17
P01876P01591['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'glomerular filtration', 'humoral immune response', 'immune response', 'innate immune response', 'positive regulation of respiratory burst', 'protein-containing complex assembly', 'retina homeostasis']
Glycerol kinase
354
Glycerol kinase
354
7.1
98
0.14
A0A287BD08A0A287BD08['glycerol catabolic process', 'glycerol metabolic process', 'glycerol-3-phosphate biosynthetic process', 'phosphorylation', 'triglyceride metabolic process']['glycerol catabolic process', 'glycerol metabolic process', 'glycerol-3-phosphate biosynthetic process', 'phosphorylation', 'triglyceride metabolic process']
Dipeptidyl peptidase 9
844
NACHT, LRR and PYD domains-containing protein 1
1288
9.3
63
0.17
Q86TI2Q9C000['proteolysis', 'pyroptosis']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'antiviral innate immune response', 'apoptotic process', 'defense response to bacterium', 'defense response to virus', 'inflammatory response', 'neuron apoptotic process', 'NLRP1 inflammasome complex assembly', 'pattern recognition receptor signaling pathway', 'positive regulation of inflammatory response', 'positive regulation of interleukin-1 beta production', 'protein homooligomerization', 'pyroptosis', 'regulation of apoptotic process', 'regulation of inflammatory response', 'response to muramyl dipeptide', 'self proteolysis']
THO complex subunit 5 homolog
59
THO complex subunit 7 homolog
60
7.5
69
0.19
Q13769Q6I9Y2['monocyte differentiation', 'mRNA export from nucleus', 'mRNA processing', 'negative regulation of DNA damage checkpoint', 'positive regulation of DNA-templated transcription, elongation', 'primitive hemopoiesis', 'RNA splicing', 'viral mRNA export from host cell nucleus']['mRNA export from nucleus', 'mRNA processing', 'RNA splicing', 'viral mRNA export from host cell nucleus']
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
N-formyl peptide receptor 2
126
6.2
75
0.21
P63096P25090['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell cycle', 'cell division', 'cellular response to forskolin', 'G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to cell cortex', 'regulation of cAMP-mediated signaling', 'regulation of mitotic spindle organization', 'response to peptide hormone']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'astrocyte activation', 'calcium-mediated signaling', 'cell adhesion', 'cell surface receptor signaling pathway', 'cellular response to amyloid-beta', 'chemotaxis', 'complement receptor mediated signaling pathway', 'defense response to bacterium', 'G protein-coupled receptor signaling pathway', 'immune response-regulating cell surface receptor signaling pathway', 'inflammatory response', 'microglial cell activation', 'negative regulation of inflammatory response', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive chemotaxis', 'positive regulation of 1-phosphatidylinositol-3-kinase activity', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of innate immune response', 'positive regulation of monocyte chemotaxis', 'positive regulation of phagocytosis', 'positive regulation of protein phosphorylation', 'positive regulation of superoxide anion generation', 'receptor-mediated endocytosis']
Insulin-like growth factor-binding protein 3
213
Insulin-like growth factor I
96
8.1
60
0.21
P17936P05019['apoptotic process', 'MAPK cascade', 'negative regulation of cell population proliferation', 'negative regulation of protein phosphorylation', 'negative regulation of signal transduction', 'negative regulation of smooth muscle cell migration', 'negative regulation of smooth muscle cell proliferation', 'osteoblast differentiation', 'positive regulation of apoptotic process', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of myoblast differentiation', 'protein phosphorylation', 'regulation of cell growth', 'regulation of glucose metabolic process', 'regulation of insulin-like growth factor receptor signaling pathway', 'type B pancreatic cell proliferation']['activation of protein kinase B activity', 'bone mineralization involved in bone maturation', 'cell activation', 'cell population proliferation', 'cellular response to amyloid-beta', 'ERK1 and ERK2 cascade', 'glycolate metabolic process', 'insulin-like growth factor receptor signaling pathway', 'muscle hypertrophy', 'muscle organ development', 'myoblast differentiation', 'myoblast proliferation', 'myotube cell development', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of gene expression', 'negative regulation of interleukin-1 beta production', 'negative regulation of neuroinflammatory response', 'negative regulation of oocyte development', 'negative regulation of release of cytochrome c from mitochondria', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of tumor necrosis factor production', 'negative regulation of vascular associated smooth muscle cell apoptotic process', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol-mediated signaling', 'positive regulation of activated T cell proliferation', 'positive regulation of calcineurin-NFAT signaling cascade', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of DNA binding', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Ras protein signal transduction', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of trophectodermal cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase B signaling', 'protein stabilization', 'proteoglycan biosynthetic process', 'Ras protein signal transduction', 'regulation of gene expression', 'regulation of multicellular organism growth', 'regulation of protein phosphorylation', 'response to heat', 'signal transduction', 'skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration', 'skeletal system development', 'wound healing']
Muscarinic acetylcholine receptor M2
124
Guanine nucleotide-binding protein G(o) subunit alpha
351
6.2
75
0.21
P08172P09471['adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'chemical synaptic transmission', 'G protein-coupled acetylcholine receptor signaling pathway', 'G protein-coupled receptor signaling pathway', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'nervous system development', 'phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway', 'regulation of heart contraction', 'regulation of smooth muscle contraction', 'regulation of synaptic vesicle exocytosis', 'response to virus']['adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'dopamine receptor signaling pathway', 'muscle contraction']
Myosin-4
817
Myosin regulatory light chain 11
128
9.3
52
0.21
Q5SX39P97457['muscle contraction', 'response to activity']['immune response', 'muscle contraction', 'skeletal muscle tissue development']
Calcium/calmodulin-dependent protein kinase type II subunit alpha
428
Calcium/calmodulin-dependent protein kinase type II subunit alpha
428
7.5
103
0.13
P11275P11275['angiotensin-activated signaling pathway', 'calcium ion transport', 'calmodulin dependent kinase signaling pathway', 'dendrite morphogenesis', 'dendritic spine development', 'G1/S transition of mitotic cell cycle', 'ionotropic glutamate receptor signaling pathway', 'negative regulation of hydrolase activity', 'NMDA selective glutamate receptor signaling pathway', 'peptidyl-serine phosphorylation', 'peptidyl-threonine autophosphorylation', 'positive regulation of calcium ion transport', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of NF-kappaB transcription factor activity', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of endocannabinoid signaling pathway', 'regulation of mitochondrial membrane permeability involved in apoptotic process', 'regulation of neuron migration', 'regulation of neuronal synaptic plasticity', 'regulation of neurotransmitter receptor localization to postsynaptic specialization membrane', 'regulation of neurotransmitter secretion', 'regulation of protein localization to plasma membrane', 'regulation of synaptic vesicle docking', 'response to ischemia']['angiotensin-activated signaling pathway', 'calcium ion transport', 'calmodulin dependent kinase signaling pathway', 'dendrite morphogenesis', 'dendritic spine development', 'G1/S transition of mitotic cell cycle', 'ionotropic glutamate receptor signaling pathway', 'negative regulation of hydrolase activity', 'NMDA selective glutamate receptor signaling pathway', 'peptidyl-serine phosphorylation', 'peptidyl-threonine autophosphorylation', 'positive regulation of calcium ion transport', 'positive regulation of cardiac muscle cell apoptotic process', 'positive regulation of NF-kappaB transcription factor activity', 'postsynaptic neurotransmitter receptor diffusion trapping', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of endocannabinoid signaling pathway', 'regulation of mitochondrial membrane permeability involved in apoptotic process', 'regulation of neuron migration', 'regulation of neuronal synaptic plasticity', 'regulation of neurotransmitter receptor localization to postsynaptic specialization membrane', 'regulation of neurotransmitter secretion', 'regulation of protein localization to plasma membrane', 'regulation of synaptic vesicle docking', 'response to ischemia']
Igh protein
478
Immunoglobulin J chain
36
2.0
73
0.67
Q99M22P01592[]['adaptive immune response', 'antibacterial humoral response', 'glomerular filtration', 'humoral immune response', 'innate immune response', 'positive regulation of respiratory burst', 'protein-containing complex assembly']
Igh protein
308
Igh protein
308
8.4
52
0.23
Q99M22Q99M22[][]
General transcription factor IIH subunit 3
282
General transcription factor IIH subunit 2
247
7.5
71
0.19
Q13889Q13888['DNA repair', 'nucleotide-excision repair', 'phosphorylation of RNA polymerase II C-terminal domain', 'transcription by RNA polymerase II']['G protein-coupled receptor internalization', 'nucleotide-excision repair', 'positive regulation of DNA helicase activity', 'regulation of transcription by RNA polymerase II', 'response to UV', 'transcription by RNA polymerase II', 'transcription initiation from RNA polymerase II promoter']
C-C motif chemokine 15
53
C-C chemokine receptor type 1
24
8.4
65
0.18
Q16663P32246['cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'signal transduction']['calcium ion transport', 'calcium-mediated signaling', 'cell adhesion', 'cell chemotaxis', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'dendritic cell chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'immune response', 'inflammatory response', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'positive regulation of calcium ion transport', 'positive regulation of cell migration', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of monocyte chemotaxis', 'positive regulation of osteoclast differentiation', 'response to wounding']
Sodium channel subunit beta-2
55
Sodium channel protein type 2 subunit alpha
912
9.2
63
0.17
O60939Q99250['cardiac muscle cell action potential involved in contraction', 'cardiac muscle contraction', 'chemical synaptic transmission', 'gene expression', 'membrane depolarization during cardiac muscle cell action potential', 'nervous system development', 'regulation of atrial cardiac muscle cell membrane depolarization', 'regulation of heart rate by cardiac conduction', 'regulation of sodium ion transmembrane transporter activity', 'response to heat', 'response to pyrethroid', 'sodium ion transmembrane transport']['cellular response to hypoxia', 'intrinsic apoptotic signaling pathway in response to osmotic stress', 'membrane depolarization during action potential', 'memory', 'myelination', 'nervous system development', 'neuron apoptotic process', 'neuronal action potential', 'regulation of ion transmembrane transport', 'sodium ion transmembrane transport', 'sodium ion transport']
COP9 signalosome complex subunit 5
308
COP9 signalosome complex subunit 6
299
9.7
79
0.13
Q92905Q7L5N1['exosomal secretion', 'negative regulation of apoptotic process', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of transcription by RNA polymerase II', 'post-translational protein modification', 'protein deneddylation', 'protein deubiquitination', 'protein neddylation', 'regulation of cell cycle', 'regulation of IRE1-mediated unfolded protein response', 'regulation of JNK cascade', 'regulation of protein neddylation', 'translation']['protein deneddylation', 'protein neddylation', 'regulation of protein neddylation']
Potassium voltage-gated channel subfamily D member 2
133
Potassium voltage-gated channel subfamily D member 2
111
4.5
65
0.34
A0A6P6DHQ6A0A6P6DHQ6['protein homooligomerization', 'regulation of ion transmembrane transport']['protein homooligomerization', 'regulation of ion transmembrane transport']
Glutamate receptor 1
323
Glutamate receptor
330
9.2
72
0.15
P23818G5E8H1['cellular response to ammonium ion', 'chemical synaptic transmission', 'long-term memory', 'long-term synaptic depression', 'modulation of chemical synaptic transmission', 'neuronal action potential', 'positive regulation of membrane potential', 'positive regulation of synaptic transmission', 'receptor internalization', 'regulation of postsynaptic membrane potential', 'regulation of receptor recycling', 'regulation of synaptic plasticity', 'response to toxic substance'][]
GATOR complex protein NPRL2
286
GATOR complex protein NPRL3
411
9.3
75
0.14
Q8WTW4Q12980['cellular response to amino acid starvation', 'negative regulation of kinase activity', 'negative regulation of TOR signaling', 'negative regulation of TORC1 signaling', 'positive regulation of autophagy']['aorta morphogenesis', 'cardiac muscle tissue development', 'cellular response to amino acid starvation', 'negative regulation of TOR signaling', 'negative regulation of TORC1 signaling', 'positive regulation of autophagy', 'roof of mouth development', 'TORC1 signaling', 'ventricular septum development']
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
139
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
9.9
87
0.12
Q9D6J6Q91YT0['aerobic respiration', 'cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development', 'proton motive force-driven mitochondrial ATP synthesis']['aerobic respiration', 'mitochondrial ATP synthesis coupled electron transport', 'mitochondrial electron transport, NADH to ubiquinone', 'proton motive force-driven mitochondrial ATP synthesis']
THO complex subunit 2
503
THO complex subunit 3
258
3.6
84
0.33
Q8NI27Q96J01['blastocyst development', 'cell morphogenesis', 'generation of neurons', 'mRNA export from nucleus', 'mRNA processing', 'negative regulation of neuron projection development', 'neuron development', 'poly(A)+ mRNA export from nucleus', 'regulation of gene expression', 'regulation of mRNA export from nucleus', 'RNA splicing', 'stem cell division', 'viral mRNA export from host cell nucleus']['mRNA export from nucleus', 'mRNA processing', 'RNA splicing', 'viral mRNA export from host cell nucleus']
Immunoglobulin heavy constant gamma 1
336
Immunoglobulin heavy constant gamma 1
336
2.0
57
0.86
A0A0A0MS08A0A0A0MS08[][]
Rhodopsin
140
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
9.2
59
0.18
P08100P63096['absorption of visible light', 'cellular response to light stimulus', 'detection of temperature stimulus involved in thermoception', 'G protein-coupled receptor signaling pathway', 'photoreceptor cell maintenance', 'phototransduction', 'phototransduction, visible light', 'protein phosphorylation', 'retina development in camera-type eye', 'rhodopsin mediated signaling pathway', 'thermotaxis', 'visual perception']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell cycle', 'cell division', 'cellular response to forskolin', 'G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to cell cortex', 'regulation of cAMP-mediated signaling', 'regulation of mitotic spindle organization', 'response to peptide hormone']
Mediator of RNA polymerase II transcription subunit 4
162
Mediator of RNA polymerase II transcription subunit 26
598
9.9
75
0.13
Q9NPJ6O95402['positive regulation of transcription elongation from RNA polymerase II promoter', 'positive regulation of transcription initiation from RNA polymerase II promoter', 'positive regulation of transcription, DNA-templated', 'regulation of transcription by RNA polymerase II', 'RNA polymerase II preinitiation complex assembly', 'transcription by RNA polymerase II']['positive regulation of gene expression', 'positive regulation of transcription elongation from RNA polymerase II promoter', 'positive regulation of transcription initiation from RNA polymerase II promoter', 'regulation of transcription by RNA polymerase II', 'RNA polymerase II preinitiation complex assembly', 'transcription initiation from RNA polymerase II promoter']
Interleukin-25
115
Interleukin-25
115
9.9
83
0.12
Q9H293Q9H293['eosinophil differentiation', 'inflammatory response to antigenic stimulus', 'positive regulation of transcription by RNA polymerase II', 'response to fungus', 'response to nematode']['eosinophil differentiation', 'inflammatory response to antigenic stimulus', 'positive regulation of transcription by RNA polymerase II', 'response to fungus', 'response to nematode']
Isoform Glur5-2 of Glutamate receptor ionotropic, kainate 1
348
Isoform Glur5-2 of Glutamate receptor ionotropic, kainate 1
348
9.7
68
0.15
P22756-2P22756-2[][]
Calcitonin gene-related peptide 1
89
Calcitonin gene-related peptide type 1 receptor
299
8.4
78
0.15
P06881Q16602['activation of adenylate cyclase activity', 'adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'amylin receptor signaling pathway', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'calcitonin gene-related peptide receptor signaling pathway', 'cell-cell signaling', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'endothelial cell migration', 'endothelial cell proliferation', 'G protein-coupled receptor internalization', 'innate immune response', 'leukocyte cell-cell adhesion', 'negative regulation of blood pressure', 'negative regulation of bone resorption', 'negative regulation of calcium ion transport into cytosol', 'negative regulation of osteoclast differentiation', 'nervous system process involved in regulation of systemic arterial blood pressure', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of interleukin-1 alpha production', 'positive regulation of interleukin-8 production', 'positive regulation of macrophage differentiation', 'protein phosphorylation', 'receptor internalization', 'regulation of blood pressure', 'regulation of cytosolic calcium ion concentration', 'response to yeast', 'vasculature development', 'vasodilation']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'adrenomedullin receptor signaling pathway', 'angiogenesis', 'calcitonin gene-related peptide receptor signaling pathway', 'calcium ion transport', 'cell surface receptor signaling pathway', 'cellular response to sucrose stimulus', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'heart development', 'negative regulation of inflammatory response', 'negative regulation of smooth muscle contraction', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein transport', 'receptor internalization', 'vascular associated smooth muscle cell proliferation']
Isoform 2 of Immunoglobulin heavy constant mu
214
Isoform 2 of Immunoglobulin heavy constant mu
214
2.0
53
0.93
P01871-2P01871-2[][]
B-cell antigen receptor complex-associated protein alpha chain
119
B-cell antigen receptor complex-associated protein beta chain
136
2.1
79
0.62
P11912P40259['adaptive immune response', 'B cell activation', 'B cell differentiation', 'B cell proliferation', 'B cell receptor signaling pathway']['adaptive immune response', 'B cell differentiation', 'B cell receptor signaling pathway', 'immune response', 'signal transduction']
ATP-binding cassette sub-family D member 1
511
ATP-binding cassette sub-family D member 1
717
9.6
52
0.2
P33897P33897['alpha-linolenic acid metabolic process', 'fatty acid beta-oxidation', 'fatty acid elongation', 'fatty acid homeostasis', 'linoleic acid metabolic process', 'long-chain fatty acid catabolic process', 'long-chain fatty acid import into peroxisome', 'myelin maintenance', 'negative regulation of cytokine production involved in inflammatory response', 'negative regulation of reactive oxygen species biosynthetic process', 'neuron projection maintenance', 'peroxisomal membrane transport', 'peroxisome organization', 'positive regulation of fatty acid beta-oxidation', 'positive regulation of unsaturated fatty acid biosynthetic process', 'regulation of cellular response to oxidative stress', 'regulation of fatty acid beta-oxidation', 'regulation of mitochondrial depolarization', 'regulation of oxidative phosphorylation', 'sterol homeostasis', 'very long-chain fatty acid catabolic process', 'very long-chain fatty acid metabolic process', 'very long-chain fatty-acyl-CoA catabolic process']['alpha-linolenic acid metabolic process', 'fatty acid beta-oxidation', 'fatty acid elongation', 'fatty acid homeostasis', 'linoleic acid metabolic process', 'long-chain fatty acid catabolic process', 'long-chain fatty acid import into peroxisome', 'myelin maintenance', 'negative regulation of cytokine production involved in inflammatory response', 'negative regulation of reactive oxygen species biosynthetic process', 'neuron projection maintenance', 'peroxisomal membrane transport', 'peroxisome organization', 'positive regulation of fatty acid beta-oxidation', 'positive regulation of unsaturated fatty acid biosynthetic process', 'regulation of cellular response to oxidative stress', 'regulation of fatty acid beta-oxidation', 'regulation of mitochondrial depolarization', 'regulation of oxidative phosphorylation', 'sterol homeostasis', 'very long-chain fatty acid catabolic process', 'very long-chain fatty acid metabolic process', 'very long-chain fatty-acyl-CoA catabolic process']
Anaphase-promoting complex subunit 10
36
Anaphase-promoting complex subunit 1
1288
7.1
64
0.22
Q9UM13Q9H1A4['anaphase-promoting complex-dependent catabolic process', 'cell cycle', 'cell division', 'protein K11-linked ubiquitination', 'regulation of meiotic cell cycle', 'regulation of mitotic cell cycle']['anaphase-promoting complex-dependent catabolic process', 'cell division', 'metaphase/anaphase transition of mitotic cell cycle', 'protein K11-linked ubiquitination', 'regulation of meiotic cell cycle', 'regulation of mitotic cell cycle']
Glutamate receptor 1
603
Glutamate receptor 2
610
6.9
81
0.18
P19490P19491['cellular response to amine stimulus', 'cellular response to amino acid stimulus', 'cellular response to ammonium ion', 'cellular response to dsRNA', 'cellular response to growth factor stimulus', 'cellular response to organic cyclic compound', 'cellular response to peptide hormone stimulus', 'chemical synaptic transmission', 'long-term memory', 'long-term synaptic depression', 'modulation of chemical synaptic transmission', 'neuronal action potential', 'positive regulation of membrane potential', 'positive regulation of synaptic transmission', 'receptor internalization', 'regulation of postsynaptic membrane potential', 'regulation of receptor recycling', 'regulation of synaptic plasticity', 'response to arsenic-containing substance', 'response to cocaine', 'response to electrical stimulus', 'response to estradiol', 'response to fungicide', 'response to lithium ion', 'response to organic cyclic compound', 'response to peptide hormone', 'response to toxic substance', 'response to xenobiotic stimulus', 'spinal cord development', 'synaptic transmission, glutamatergic']['chemical synaptic transmission', 'establishment of protein localization', 'ionotropic glutamate receptor signaling pathway', 'positive regulation of synaptic transmission', 'protein tetramerization', 'receptor internalization', 'regulation of receptor recycling', 'regulation of synaptic transmission, glutamatergic', 'response to fungicide', 'response to lithium ion']
DNA-directed RNA polymerase II subunit RPB1
1430
DNA-directed RNA polymerase subunit beta
1155
9.4
82
0.13
P11414A0A0B8RVL1['positive regulation of RNA splicing', 'transcription by RNA polymerase II']['transcription, DNA-templated']
Integrator complex subunit 2
722
Integrator complex subunit 7
82
8.3
77
0.16
Q9H0H0Q9NVH2['regulation of transcription elongation from RNA polymerase II promoter', "snRNA 3'-end processing", 'snRNA processing']['cellular response to ionizing radiation', 'DNA damage checkpoint signaling', 'regulation of transcription elongation from RNA polymerase II promoter', "snRNA 3'-end processing", 'snRNA processing']
Glycoprotein hormones alpha chain
111
Thyrotropin subunit beta
51
9.7
75
0.14
P01215P01222['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['anatomical structure morphogenesis', 'cell-cell signaling', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'response to calcium ion', 'response to estrogen', 'response to vitamin A']
Insulin receptor
710
Insulin receptor
710
2.0
44
1.12
P06213P06213['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell']['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell']
Dedicator of cytokinesis protein 2
41
Engulfment and cell motility protein 1
726
9.1
nan
nan
Q92608Q92556['actin cytoskeleton organization', 'alpha-beta T cell proliferation', 'cell migration', 'chemotaxis', 'establishment of T cell polarity', 'immunological synapse formation', 'macropinocytosis', 'membrane raft polarization', 'myeloid dendritic cell activation involved in immune response', 'myoblast fusion', 'negative thymic T cell selection', 'positive regulation of phagocytosis', 'positive thymic T cell selection', 'regulation of small GTPase mediated signal transduction', 'small GTPase mediated signal transduction']['actin cytoskeleton organization', 'actin filament organization', 'actin filament-based process', 'apoptotic process', 'cell migration', 'cell motility', 'phagocytosis, engulfment', 'Rac protein signal transduction', 'regulation of catalytic activity']
Glycoprotein hormones alpha chain
55
Choriogonadotropin subunit beta 3
110
7.3
72
0.19
P01215P0DN86['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['apoptotic process', 'cell-cell signaling', 'female gamete generation', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'signal transduction']
Calcium uptake protein 2, mitochondrial
413
Calcium uptake protein 1, mitochondrial
463
2.0
52
0.94
1
✔Q8IYU8Q9BPX6['calcium import into the mitochondrion', 'mitochondrial calcium ion homeostasis', 'mitochondrial calcium ion transmembrane transport', 'negative regulation of mitochondrial calcium ion concentration', 'positive regulation of mitochondrial calcium ion concentration']['calcium import into the mitochondrion', 'calcium ion import', 'defense response', 'mitochondrial calcium ion homeostasis', 'mitochondrial calcium ion transmembrane transport', 'positive regulation of mitochondrial calcium ion concentration', 'protein homooligomerization', 'regulation of cellular hyperosmotic salinity response']
Glutamate receptor ionotropic, kainate 3
350
Glutamate receptor ionotropic, kainate 3
350
9.7
62
0.17
P42264P42264['chemical synaptic transmission', 'G protein-coupled glutamate receptor signaling pathway', 'glutamate receptor signaling pathway', 'modulation of chemical synaptic transmission', 'negative regulation of synaptic transmission, glutamatergic', 'regulation of membrane potential', 'synaptic transmission, glutamatergic']['chemical synaptic transmission', 'G protein-coupled glutamate receptor signaling pathway', 'glutamate receptor signaling pathway', 'modulation of chemical synaptic transmission', 'negative regulation of synaptic transmission, glutamatergic', 'regulation of membrane potential', 'synaptic transmission, glutamatergic']
4F2 cell-surface antigen heavy chain
210
Cystine/glutamate transporter
158
2.0
43
1.15
P08195Q9UPY5['amino acid transport', 'calcium ion transport', 'carbohydrate metabolic process', 'L-alanine import across plasma membrane', 'L-leucine import across plasma membrane', 'leucine import across plasma membrane', 'leucine transport', 'phenylalanine transport', 'response to exogenous dsRNA', 'tryptophan transport', 'viral entry into host cell']['adult behavior', 'cellular response to oxidative stress', 'dipeptide import across plasma membrane', 'glutamate homeostasis', 'glutathione metabolic process', 'glutathione transmembrane transport', 'L-glutamate import across plasma membrane', 'lens fiber cell differentiation', 'limb development', 'lung alveolus development', 'modulation of chemical synaptic transmission', 'negative regulation of oxidative stress-induced neuron death', 'platelet aggregation', 'regulation of AMPA glutamate receptor clustering', 'regulation of cell population proliferation', 'regulation of cysteine metabolic process', 'regulation of glutamate metabolic process', 'regulation of glutathione biosynthetic process', 'regulation of melanin biosynthetic process', 'regulation of neutrophil apoptotic process', 'regulation of protein transport', 'regulation of synapse organization', 'response to nicotine', 'response to organic cyclic compound', 'response to redox state', 'response to toxic substance', 'striatum development', 'ventricular system development', 'visual learning']
Clathrin heavy chain 1
1569
Clathrin light chain B
198
8.4
70
0.17
P49951P04975['amyloid-beta clearance by transcytosis', 'autophagy', 'cell division', 'clathrin coat assembly', 'clathrin-dependent endocytosis', 'intracellular protein transport', 'mitotic cell cycle', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of protein localization to plasma membrane', 'receptor internalization', 'receptor-mediated endocytosis', 'regulation of mitotic spindle organization', 'retrograde transport, endosome to Golgi', 'transferrin transport']['clathrin-dependent endocytosis', 'intracellular protein transport']
DNA-directed RNA polymerase I subunit RPA1
539
DNA-directed RNA polymerase I subunit RPA2
1061
9.7
77
0.13
O95602Q9H9Y6['negative regulation of protein localization to nucleolus']['embryo implantation', 'neural crest formation', 'nucleologenesis', 'rRNA transcription']
DNA repair protein XRCC4
165
DNA ligase 4
901
9.9
57
0.18
Q13426P49917['DNA ligation involved in DNA repair', 'double-strand break repair', 'double-strand break repair via nonhomologous end joining', 'immunoglobulin V(D)J recombination', 'positive regulation of ligase activity', 'positive regulation of phosphatidylserine exposure on apoptotic cell surface', 'protein localization to site of double-strand break', 'response to X-ray']['cell cycle', 'cell division', 'cell population proliferation', 'cellular response to ionizing radiation', 'cellular response to lithium ion', 'central nervous system development', 'chromosome organization', 'DN2 thymocyte differentiation', 'DNA biosynthetic process', 'DNA ligation', 'DNA ligation involved in DNA recombination', 'DNA ligation involved in DNA repair', 'DNA replication', 'double-strand break repair', 'double-strand break repair via classical nonhomologous end joining', 'double-strand break repair via nonhomologous end joining', 'establishment of integrated proviral latency', 'fibroblast proliferation', 'immunoglobulin V(D)J recombination', 'in utero embryonic development', 'isotype switching', 'negative regulation of neuron apoptotic process', 'neurogenesis', 'neuron apoptotic process', 'nucleotide-excision repair, DNA gap filling', 'positive regulation of chromosome organization', 'positive regulation of fibroblast proliferation', 'positive regulation of neurogenesis', 'pro-B cell differentiation', 'response to gamma radiation', 'response to X-ray', 'single strand break repair', 'somatic stem cell population maintenance', 'stem cell proliferation', 'T cell differentiation in thymus', 'T cell receptor V(D)J recombination', 'V(D)J recombination']
Igh protein
306
Igh protein
306
2.0
48
1.03
Q99M22Q99M22[][]
Dynactin subunit 5
149
Uncharacterized protein
79
9.3
73
0.15
A0A286ZK88A0A4X1TB62['aorta development', 'coronary vasculature development', 'ventricular septum development'][]
Lutropin-choriogonadotropic hormone receptor
156
Choriogonadotropin subunit beta 3
113
9.4
78
0.14
P22888P0DN86['activation of adenylate cyclase activity', 'adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'arachidonic acid secretion', 'cellular response to gonadotropin stimulus', 'cellular response to luteinizing hormone stimulus', 'central nervous system development', 'cognition', 'development of secondary male sexual characteristics', 'G protein-coupled receptor signaling pathway', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'hormone-mediated signaling pathway', 'luteinizing hormone signaling pathway', 'male genitalia development', 'male gonad development', 'ovarian follicle development', 'ovulation cycle process', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of calcium ion transport into cytosol', 'positive regulation of calcium-mediated signaling', 'positive regulation of hormone biosynthetic process', 'positive regulation of inositol trisphosphate biosynthetic process', 'positive regulation of release of sequestered calcium ion into cytosol', 'protein targeting to lysosome', 'regulation of steroid hormone biosynthetic process', 'response to xenobiotic stimulus', 'seminiferous tubule development', 'spermatogenesis', 'uterus development']['apoptotic process', 'cell-cell signaling', 'female gamete generation', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'signal transduction']
Integrator complex subunit 2
722
Integrator complex subunit 7
42
7.1
79
0.18
Q9H0H0Q9NVH2['regulation of transcription elongation from RNA polymerase II promoter', "snRNA 3'-end processing", 'snRNA processing']['cellular response to ionizing radiation', 'DNA damage checkpoint signaling', 'regulation of transcription elongation from RNA polymerase II promoter', "snRNA 3'-end processing", 'snRNA processing']
RNA polymerase-associated protein CTR9 homolog
511
WD repeat-containing protein 61
266
9.9
57
0.18
Q6PD62Q9GZS3['blastocyst growth', 'blastocyst hatching', 'cellular response to lipopolysaccharide', 'endodermal cell fate commitment', 'histone H2B ubiquitination', 'histone H3-K4 trimethylation', 'histone monoubiquitination', 'inner cell mass cell differentiation', 'interleukin-6-mediated signaling pathway', 'negative regulation of myeloid cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of histone H3-K4 methylation', 'positive regulation of histone H3-K79 methylation', 'receptor signaling pathway via JAK-STAT', 'regulation of genetic imprinting', 'regulation of histone H3-K4 methylation', 'regulation of transcription, DNA-templated', 'stem cell population maintenance', 'transcription elongation from RNA polymerase II promoter', 'trophectodermal cell differentiation', 'Wnt signaling pathway']['histone H3-K4 methylation', 'histone H3-K4 trimethylation', 'negative regulation of myeloid cell differentiation', 'positive regulation of histone H3-K4 methylation', 'positive regulation of histone H3-K79 methylation', 'transcription elongation from RNA polymerase II promoter', 'Wnt signaling pathway']
T-cell surface glycoprotein CD3 gamma chain
107
T-cell surface glycoprotein CD3 epsilon chain
119
4.2
61
0.39
P09693P07766['adaptive immune response', 'alpha-beta T cell activation', 'cell surface receptor signaling pathway', 'establishment or maintenance of cell polarity', 'gamma-delta T cell activation', 'positive thymic T cell selection', 'protein transport', 'protein-containing complex assembly', 'regulation of lymphocyte apoptotic process', 'T cell activation', 'T cell receptor signaling pathway']['adaptive immune response', 'alpha-beta T cell activation', 'apoptotic signaling pathway', 'calcium-mediated signaling', 'CD4-positive, alpha-beta T cell proliferation', 'cell surface receptor signaling pathway', 'cerebellum development', 'dendrite development', 'G protein-coupled receptor signaling pathway', 'gamma-delta T cell activation', 'negative regulation of gene expression', 'negative regulation of smoothened signaling pathway', 'negative thymic T cell selection', 'peptidyl-tyrosine phosphorylation', 'positive regulation of calcium-mediated signaling', 'positive regulation of CD4-positive, alpha-beta T cell proliferation', 'positive regulation of cell-cell adhesion mediated by integrin', 'positive regulation of cell-matrix adhesion', 'positive regulation of gene expression', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-2 production', 'positive regulation of interleukin-4 production', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of T cell anergy', 'positive regulation of T cell proliferation', 'positive thymic T cell selection', 'protein-containing complex assembly', 'regulation of apoptotic process', 'signal complex assembly', 'smoothened signaling pathway', 'T cell activation', 'T cell anergy', 'T cell costimulation', 'T cell receptor signaling pathway', 'transmembrane receptor protein tyrosine kinase signaling pathway']
Voltage-dependent anion-selective channel protein 2
103
Voltage-dependent anion-selective channel protein 2
210
4.2
50
0.48
F1S2F6F1S2F6[][]
Insulin
109
Insulin
43
4.5
50
0.44
P01308P01318['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['cellular response to palmitoleic acid', 'glucose metabolic process', 'response to L-arginine']
Broad substrate specificity ATP-binding cassette transporter ABCG2
438
Broad substrate specificity ATP-binding cassette transporter ABCG2
438
9.7
100
0.1
Q9UNQ0Q9UNQ0['biotin transport', 'cellular detoxification', 'export across plasma membrane', 'lipid transport', 'organic anion transport', 'renal urate salt excretion', 'riboflavin transport', 'transepithelial transport', 'transmembrane transport', 'transport across blood-brain barrier', 'urate metabolic process', 'xenobiotic transport across blood-brain barrier']['biotin transport', 'cellular detoxification', 'export across plasma membrane', 'lipid transport', 'organic anion transport', 'renal urate salt excretion', 'riboflavin transport', 'transepithelial transport', 'transmembrane transport', 'transport across blood-brain barrier', 'urate metabolic process', 'xenobiotic transport across blood-brain barrier']
Tropomyosin alpha-1 chain
190
Tropomyosin alpha-1 chain
190
6.3
65
0.24
1
✔P58771P58771['actin filament capping', 'actin filament organization', 'cardiac muscle contraction', 'in utero embryonic development', 'muscle contraction', 'muscle filament sliding', 'negative regulation of cell migration', 'negative regulation of vascular associated smooth muscle cell migration', 'negative regulation of vascular associated smooth muscle cell proliferation', 'positive regulation of ATP-dependent activity', 'positive regulation of cell adhesion', 'positive regulation of heart rate by epinephrine', 'positive regulation of stress fiber assembly', 'regulation of ATP-dependent activity', 'regulation of cell shape', 'ruffle organization', 'sarcomere organization', 'ventricular cardiac muscle tissue morphogenesis', 'wound healing']['actin filament capping', 'actin filament organization', 'cardiac muscle contraction', 'in utero embryonic development', 'muscle contraction', 'muscle filament sliding', 'negative regulation of cell migration', 'negative regulation of vascular associated smooth muscle cell migration', 'negative regulation of vascular associated smooth muscle cell proliferation', 'positive regulation of ATP-dependent activity', 'positive regulation of cell adhesion', 'positive regulation of heart rate by epinephrine', 'positive regulation of stress fiber assembly', 'regulation of ATP-dependent activity', 'regulation of cell shape', 'ruffle organization', 'sarcomere organization', 'ventricular cardiac muscle tissue morphogenesis', 'wound healing']
Ion channel TACAN
173
Ion channel TACAN
173
9.0
65
0.17
Q8C1E7Q8C1E7['detection of mechanical stimulus involved in sensory perception of pain', 'fat cell differentiation', 'ion transmembrane transport', 'protein heterooligomerization', 'protein homooligomerization']['detection of mechanical stimulus involved in sensory perception of pain', 'fat cell differentiation', 'ion transmembrane transport', 'protein heterooligomerization', 'protein homooligomerization']
Protein tweety homolog 2
101
Protein tweety homolog 2
227
8.4
69
0.17
Q9BSA4Q9BSA4[][]
Glutamate receptor ionotropic, kainate 3
350
Glutamate receptor ionotropic, kainate 3
99
7.9
61
0.21
P42264P42264['chemical synaptic transmission', 'G protein-coupled glutamate receptor signaling pathway', 'glutamate receptor signaling pathway', 'modulation of chemical synaptic transmission', 'negative regulation of synaptic transmission, glutamatergic', 'regulation of membrane potential', 'synaptic transmission, glutamatergic']['chemical synaptic transmission', 'G protein-coupled glutamate receptor signaling pathway', 'glutamate receptor signaling pathway', 'modulation of chemical synaptic transmission', 'negative regulation of synaptic transmission, glutamatergic', 'regulation of membrane potential', 'synaptic transmission, glutamatergic']
Potassium voltage-gated channel subfamily D member 2
236
Dipeptidyl aminopeptidase-like protein 6
107
9.3
58
0.19
Q9NZV8P42658['action potential', 'cellular response to hypoxia', 'chemical synaptic transmission', 'locomotor rhythm', 'neuronal action potential', 'potassium ion transmembrane transport', 'protein homooligomerization', 'regulation of ion transmembrane transport', 'sensory perception of pain']['protein localization to plasma membrane', 'proteolysis', 'regulation of potassium ion transmembrane transport']
Protein tweety homolog 1
102
Protein tweety homolog 1
102
4.3
82
0.29
Q9H313Q9H313['cell-cell adhesion', 'cell-substrate adhesion', 'chloride transport', 'filopodium assembly', 'ion transmembrane transport', 'iron ion transport', 'mitotic cell cycle']['cell-cell adhesion', 'cell-substrate adhesion', 'chloride transport', 'filopodium assembly', 'ion transmembrane transport', 'iron ion transport', 'mitotic cell cycle']
Mucin-2
1088
Mucin-2
1088
4.3
76
0.31
A0A0G2JR65A0A0G2JR65[][]
DNA replication licensing factor MCM3
243
DNA replication licensing factor MCM5
221
4.3
77
0.3
P25205P33992['DNA replication initiation', 'DNA strand elongation involved in DNA replication', 'DNA unwinding involved in DNA replication', 'double-strand break repair via break-induced replication', 'mitotic DNA replication initiation', 'regulation of DNA-templated DNA replication initiation']['cell cycle', 'DNA replication', 'DNA replication initiation', 'DNA unwinding involved in DNA replication', 'double-strand break repair via break-induced replication', 'regulation of DNA-templated DNA replication initiation']
Transmembrane protein 120B
8
Transmembrane protein 120B
64
6.6
48
0.32
A0PK00A0PK00['fat cell differentiation', 'protein heterooligomerization']['fat cell differentiation', 'protein heterooligomerization']
Toll-like receptor 5
646
Toll-like receptor 5
646
9.3
45
0.24
O60602O60602['cellular response to mechanical stimulus', 'defense response to bacterium', 'inflammatory response', 'innate immune response', 'MyD88-dependent toll-like receptor signaling pathway', 'positive regulation of interleukin-8 production', 'positive regulation of toll-like receptor signaling pathway', 'toll-like receptor 5 signaling pathway', 'toll-like receptor signaling pathway']['cellular response to mechanical stimulus', 'defense response to bacterium', 'inflammatory response', 'innate immune response', 'MyD88-dependent toll-like receptor signaling pathway', 'positive regulation of interleukin-8 production', 'positive regulation of toll-like receptor signaling pathway', 'toll-like receptor 5 signaling pathway', 'toll-like receptor signaling pathway']
E3 ubiquitin-protein ligase ARIH1
357
Ubiquitin-conjugating enzyme E2 L3
86
4.4
65
0.35
Q9Y4X5P68036['positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'protein polyubiquitination', 'protein ubiquitination', 'ubiquitin-dependent protein catabolic process']['cell cycle phase transition', 'cell population proliferation', 'cellular response to glucocorticoid stimulus', 'cellular response to steroid hormone stimulus', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of protein ubiquitination', 'positive regulation of ubiquitin-protein transferase activity', 'protein K11-linked ubiquitination', 'protein modification process', 'protein polyubiquitination', 'protein ubiquitination', 'regulation of transcription, DNA-templated', 'ubiquitin-dependent protein catabolic process']
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
Adhesion G-protein coupled receptor F1
626
9.7
74
0.14
P63096Q5T601['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell cycle', 'cell division', 'cellular response to forskolin', 'G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to cell cortex', 'regulation of cAMP-mediated signaling', 'regulation of mitotic spindle organization', 'response to peptide hormone']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'cell surface receptor signaling pathway', 'G protein-coupled receptor signaling pathway', 'memory', 'neuron projection development', 'positive regulation of CREB transcription factor activity', 'synapse assembly']
Atypical chemokine receptor 3
34
Stromal cell-derived factor 1
55
9.0
67
0.17
P25106P48061['angiogenesis', 'calcium-mediated signaling', 'cell adhesion', 'cell chemotaxis', 'chemokine-mediated signaling pathway', 'immune response', 'negative regulation of cell population proliferation', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'oculomotor nerve development', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of mesenchymal stem cell migration', 'receptor internalization', 'vasculogenesis']['adult locomotory behavior', 'animal organ regeneration', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'axon guidance', 'blood circulation', 'cell adhesion', 'cell chemotaxis', 'cellular calcium ion homeostasis', 'cellular response to chemokine', 'chemokine (C-X-C motif) ligand 12 signaling pathway', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response', 'detection of mechanical stimulus involved in sensory perception of pain', 'detection of temperature stimulus involved in sensory perception of pain', 'G protein-coupled receptor signaling pathway', 'immune response', 'induction of positive chemotaxis', 'integrin activation', 'killing of cells of another organism', 'negative regulation of dendritic cell apoptotic process', 'negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage', 'negative regulation of leukocyte tethering or rolling', 'neuron migration', 'positive regulation of axon extension involved in axon guidance', 'positive regulation of calcium ion import', 'positive regulation of cell adhesion', 'positive regulation of cell migration', 'positive regulation of dopamine secretion', 'positive regulation of endothelial cell proliferation', 'positive regulation of monocyte chemotaxis', 'positive regulation of neuron differentiation', 'positive regulation of T cell migration', 'regulation of actin polymerization or depolymerization', 'response to heat', 'response to hypoxia', 'response to peptide hormone', 'response to radiation', 'response to ultrasound', 'response to virus', 'signal transduction', 'T cell chemotaxis', 'telencephalon cell migration']
Glycoprotein hormones alpha chain
111
Thyrotropin subunit beta
115
9.7
74
0.14
P01215P01222['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['anatomical structure morphogenesis', 'cell-cell signaling', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'response to calcium ion', 'response to estrogen', 'response to vitamin A']
DNA-directed RNA polymerase III subunit RPC1
113
DNA-directed RNA polymerase III subunit RPC3
79
8.1
75
0.17
O14802Q9BUI4['defense response to virus', 'innate immune response', 'positive regulation of interferon-beta production', 'transcription, DNA-templated']['defense response to virus', 'innate immune response', 'positive regulation of innate immune response', 'positive regulation of interferon-beta production', 'regulation of transcription by RNA polymerase III', 'transcription, DNA-templated']
cAMP-dependent protein kinase catalytic subunit alpha
200
cAMP-dependent protein kinase type II-beta regulatory subunit
114
8.4
66
0.18
P17612P12369['calcium-mediated signaling using intracellular calcium source', 'cell communication by electrical coupling involved in cardiac conduction', 'cellular response to cold', 'cellular response to epinephrine stimulus', 'cellular response to glucose stimulus', 'cellular response to heat', 'cellular response to parathyroid hormone stimulus', 'cytokine-mediated signaling pathway', 'high-density lipoprotein particle assembly', 'mesoderm formation', 'modulation of chemical synaptic transmission', 'mRNA processing', 'negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning', 'neural tube closure', 'peptidyl-serine phosphorylation', 'peptidyl-threonine phosphorylation', 'positive regulation of protein export from nucleus', 'protein autophosphorylation', 'protein export from nucleus', 'protein kinase A signaling', 'protein localization to lipid droplet', 'protein phosphorylation', 'regulation of bicellular tight junction assembly', 'regulation of cardiac conduction', 'regulation of cardiac muscle contraction', 'regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion', 'regulation of cell cycle', 'regulation of cytosolic calcium ion concentration', 'regulation of heart rate', 'regulation of macroautophagy', 'regulation of osteoblast differentiation', 'regulation of proteasomal protein catabolic process', 'regulation of protein binding', 'regulation of protein processing', 'regulation of ryanodine-sensitive calcium-release channel activity', 'renal water homeostasis', 'sperm capacitation']['fatty acid metabolic process', 'learning', 'modulation of chemical synaptic transmission', 'negative regulation of cAMP-dependent protein kinase activity', 'regulation of protein kinase activity', 'response to antipsychotic drug', 'response to clozapine']
4F2 cell-surface antigen heavy chain
211
Large neutral amino acids transporter small subunit 2
154
2.0
47
1.05
J3KPF3Q9UHI5['amino acid transport', 'carbohydrate metabolic process']['amino acid import across plasma membrane', 'amino acid transport', 'glycine transport', 'L-alanine import across plasma membrane', 'L-leucine import across plasma membrane', 'leucine import across plasma membrane', 'leucine transport', 'metal ion homeostasis', 'neutral amino acid transport', 'proline transmembrane transport', 'response to toxic substance', 'thyroid hormone transport', 'transport across blood-brain barrier', 'tryptophan transport', 'valine transport']
C-C motif chemokine 15
93
C-C chemokine receptor type 1
273
9.3
73
0.15
Q16663P32246['cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'signal transduction']['calcium ion transport', 'calcium-mediated signaling', 'cell adhesion', 'cell chemotaxis', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'dendritic cell chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'immune response', 'inflammatory response', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'positive regulation of calcium ion transport', 'positive regulation of cell migration', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of monocyte chemotaxis', 'positive regulation of osteoclast differentiation', 'response to wounding']
Immunoglobulin heavy constant alpha 2
339
Immunoglobulin J chain
91
2.0
68
0.73
P01877P01591['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'glomerular filtration', 'humoral immune response', 'immune response', 'innate immune response', 'positive regulation of respiratory burst', 'protein-containing complex assembly', 'retina homeostasis']
Glycoprotein hormones alpha chain
111
Thyrotropin subunit beta
108
9.3
69
0.16
P01215P01222['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['anatomical structure morphogenesis', 'cell-cell signaling', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'response to calcium ion', 'response to estrogen', 'response to vitamin A']
Insulin
96
Insulin
31
2.0
67
0.74
P01308P01318['activation of protein kinase B activity', 'acute-phase response', 'alpha-beta T cell activation', 'cell-cell signaling', 'cognition', 'fatty acid homeostasis', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'glucose metabolic process', 'insulin receptor signaling pathway', 'negative regulation of acute inflammatory response', 'negative regulation of fatty acid metabolic process', 'negative regulation of feeding behavior', 'negative regulation of gene expression', 'negative regulation of gluconeogenesis', 'negative regulation of glycogen catabolic process', 'negative regulation of lipid catabolic process', 'negative regulation of NAD(P)H oxidase activity', 'negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'negative regulation of protein catabolic process', 'negative regulation of protein secretion', 'negative regulation of proteolysis', 'negative regulation of reactive oxygen species biosynthetic process', 'negative regulation of respiratory burst involved in inflammatory response', 'neuron projection maintenance', 'nitric oxide-cGMP-mediated signaling pathway', 'positive regulation of brown fat cell differentiation', 'positive regulation of cell differentiation', 'positive regulation of cell growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cytokine production', 'positive regulation of dendritic spine maintenance', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of lipid biosynthetic process', 'positive regulation of long-term synaptic potentiation', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of NF-kappaB transcription factor activity', 'positive regulation of nitric oxide mediated signal transduction', 'positive regulation of nitric-oxide synthase activity', 'positive regulation of peptide hormone secretion', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein autophosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein secretion', 'positive regulation of respiratory burst', 'regulation of cellular amino acid metabolic process', 'regulation of protein localization', 'regulation of protein localization to plasma membrane', 'regulation of protein secretion', 'regulation of synaptic plasticity', 'regulation of transcription, DNA-templated', 'regulation of transmembrane transporter activity', 'vasodilation', 'wound healing']['cellular response to palmitoleic acid', 'glucose metabolic process', 'response to L-arginine']
Splicing factor 3B subunit 1
677
PHD finger-like domain-containing protein 5A
85
9.9
69
0.15
O75533Q7RTV0['chromatin remodeling', 'mRNA splicing, via spliceosome', 'positive regulation of histone acetylation', 'positive regulation of transcription by RNA polymerase I', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase III', 'RNA splicing', 'RNA splicing, via transesterification reactions', 'spliceosomal complex assembly', 'U2-type prespliceosome assembly']['mRNA splicing, via spliceosome', 'positive regulation of transcription, DNA-templated', 'stem cell differentiation', 'U2-type prespliceosome assembly']
ATPase GET3
292
ATPase GET3
292
3.3
79
0.38
O43681O43681['post-translational protein targeting to endoplasmic reticulum membrane', 'protein insertion into ER membrane', 'tail-anchored membrane protein insertion into ER membrane']['post-translational protein targeting to endoplasmic reticulum membrane', 'protein insertion into ER membrane', 'tail-anchored membrane protein insertion into ER membrane']
Serine/threonine-protein kinase SMG1
492
Nonsense-mediated mRNA decay factor SMG9
380
4.5
69
0.32
Q96Q15Q9H0W8['DNA repair', 'mRNA export from nucleus', 'negative regulation of macroautophagy', 'nuclear-transcribed mRNA catabolic process, nonsense-mediated decay', 'peptidyl-serine phosphorylation', 'phosphatidylinositol phosphate biosynthetic process', 'protein autophosphorylation', 'protein phosphorylation', 'regulation of response to DNA damage stimulus', 'regulation of telomere maintenance', 'TOR signaling']['brain development', 'eye development', 'heart development', 'in utero embryonic development', 'nuclear-transcribed mRNA catabolic process, nonsense-mediated decay']
Protein inturned
838
Protein fuzzy homolog
365
9.2
82
0.13
Q9ULD6Q9BT04['cell division', 'cilium assembly', 'embryonic digit morphogenesis', 'establishment of planar polarity', 'hair follicle morphogenesis', 'intraciliary transport', 'keratinocyte differentiation', 'limb development', 'motile cilium assembly', 'negative regulation of cell division', 'negative regulation of keratinocyte proliferation', 'nervous system development', 'neural tube development', 'non-motile cilium assembly', 'positive regulation of smoothened signaling pathway', 'protein localization to organelle', 'regulation of cilium assembly', 'regulation of ossification', 'regulation of smoothened signaling pathway', 'roof of mouth development', 'smoothened signaling pathway', 'spinal cord dorsal/ventral patterning', 'tongue morphogenesis', 'vesicle-mediated transport']['cilium assembly', 'embryonic body morphogenesis', 'embryonic skeletal system morphogenesis', 'establishment of planar polarity', 'hair follicle development', 'intraciliary transport', 'negative regulation of canonical Wnt signaling pathway', 'negative regulation of cell migration', 'negative regulation of cell population proliferation', 'negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation', 'negative regulation of neural crest formation', 'neural tube closure', 'neural tube development', 'non-motile cilium assembly', 'positive regulation of cilium assembly', 'protein transport', 'regulation of cilium assembly', 'regulation of smoothened signaling pathway', 'vesicle-mediated transport']
Protein ADM2
110
Calcitonin gene-related peptide type 1 receptor
299
9.7
70
0.15
Q7Z4H4Q16602['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'angiogenesis', 'digestion', 'feeding behavior', 'negative regulation of blood pressure', 'positive regulation of angiogenesis', 'positive regulation of gene expression', 'positive regulation of heart rate', 'protein phosphorylation', 'regulation of systemic arterial blood pressure']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'adrenomedullin receptor signaling pathway', 'angiogenesis', 'calcitonin gene-related peptide receptor signaling pathway', 'calcium ion transport', 'cell surface receptor signaling pathway', 'cellular response to sucrose stimulus', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'heart development', 'negative regulation of inflammatory response', 'negative regulation of smooth muscle contraction', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein transport', 'receptor internalization', 'vascular associated smooth muscle cell proliferation']
Lutropin-choriogonadotropic hormone receptor
131
Choriogonadotropin subunit beta 3
120
8.4
82
0.15
P22888P0DN86['activation of adenylate cyclase activity', 'adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'arachidonic acid secretion', 'cellular response to gonadotropin stimulus', 'cellular response to luteinizing hormone stimulus', 'central nervous system development', 'cognition', 'development of secondary male sexual characteristics', 'G protein-coupled receptor signaling pathway', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'hormone-mediated signaling pathway', 'luteinizing hormone signaling pathway', 'male genitalia development', 'male gonad development', 'ovarian follicle development', 'ovulation cycle process', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of calcium ion transport into cytosol', 'positive regulation of calcium-mediated signaling', 'positive regulation of hormone biosynthetic process', 'positive regulation of inositol trisphosphate biosynthetic process', 'positive regulation of release of sequestered calcium ion into cytosol', 'protein targeting to lysosome', 'regulation of steroid hormone biosynthetic process', 'response to xenobiotic stimulus', 'seminiferous tubule development', 'spermatogenesis', 'uterus development']['apoptotic process', 'cell-cell signaling', 'female gamete generation', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'signal transduction']
Pro-adrenomedullin
115
Calcitonin gene-related peptide type 1 receptor
299
9.2
69
0.16
P35318Q16602['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adrenomedullin receptor signaling pathway', 'aging', 'amylin receptor signaling pathway', 'androgen metabolic process', 'animal organ regeneration', 'antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'branching involved in labyrinthine layer morphogenesis', 'calcium ion homeostasis', 'cAMP-mediated signaling', 'cell population proliferation', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'developmental growth', 'female pregnancy', 'G protein-coupled receptor internalization', 'heart development', 'hormone secretion', 'inflammatory response', 'negative regulation of cell population proliferation', 'negative regulation of vascular permeability', 'negative regulation of vasoconstriction', 'neural tube closure', 'neuron projection regeneration', 'odontogenesis of dentin-containing tooth', 'positive regulation of angiogenesis', 'positive regulation of apoptotic process', 'positive regulation of cell population proliferation', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of heart rate', 'positive regulation of progesterone biosynthetic process', 'positive regulation of vasculogenesis', 'receptor internalization', 'regulation of systemic arterial blood pressure', 'regulation of the force of heart contraction', 'regulation of urine volume', 'response to cold', 'response to glucocorticoid', 'response to hypoxia', 'response to insulin', 'response to lipopolysaccharide', 'response to starvation', 'response to wounding', 'signal transduction', 'spongiotrophoblast layer development', 'vascular associated smooth muscle cell development', 'vasculogenesis']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'adrenomedullin receptor signaling pathway', 'angiogenesis', 'calcitonin gene-related peptide receptor signaling pathway', 'calcium ion transport', 'cell surface receptor signaling pathway', 'cellular response to sucrose stimulus', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'heart development', 'negative regulation of inflammatory response', 'negative regulation of smooth muscle contraction', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein transport', 'receptor internalization', 'vascular associated smooth muscle cell proliferation']
Glutamate receptor 1
75
Glutamate receptor
78
8.4
68
0.17
P23818G5E8H1['cellular response to ammonium ion', 'chemical synaptic transmission', 'long-term memory', 'long-term synaptic depression', 'modulation of chemical synaptic transmission', 'neuronal action potential', 'positive regulation of membrane potential', 'positive regulation of synaptic transmission', 'receptor internalization', 'regulation of postsynaptic membrane potential', 'regulation of receptor recycling', 'regulation of synaptic plasticity', 'response to toxic substance'][]
DNA-directed RNA polymerase III subunit RPC5
70
DNA-directed RNA polymerase III subunit RPC10
20
9.5
49
0.21
Q9NVU0Q9Y2Y1['defense response to virus', 'innate immune response', 'transcription, DNA-templated']['defense response to virus', 'innate immune response', 'termination of RNA polymerase III transcription', 'transcription by RNA polymerase III', "tRNA 3'-trailer cleavage"]
Immunoglobulin heavy constant alpha 1
182
Immunoglobulin heavy constant alpha 1
182
9.9
43
0.23
P01876P01876['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']
Potassium channel TASK2
51
Potassium channel TASK2
51
2.0
36
1.37
Q9JK62Q9JK62['potassium ion export across plasma membrane', 'potassium ion import across plasma membrane', 'potassium ion transmembrane transport', 'potassium ion transport', 'regulation of resting membrane potential', 'stabilization of membrane potential']['potassium ion export across plasma membrane', 'potassium ion import across plasma membrane', 'potassium ion transmembrane transport', 'potassium ion transport', 'regulation of resting membrane potential', 'stabilization of membrane potential']
Glial cell line-derived neurotrophic factor
178
Glial cell line-derived neurotrophic factor
178
2.1
63
0.76
P39905P39905['adult locomotory behavior', 'branching involved in ureteric bud morphogenesis', 'commissural neuron axon guidance', 'dorsal spinal cord development', 'embryonic organ development', 'enteric nervous system development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'metanephros development', 'mRNA stabilization', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of neuron apoptotic process', 'nervous system development', 'neural crest cell migration', 'neuron projection development', 'organ induction', 'peripheral nervous system development', 'peristalsis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of dopamine secretion', 'positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis', 'positive regulation of monooxygenase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of ureteric bud formation', 'postganglionic parasympathetic fiber development', 'postsynaptic membrane organization', 'regulation of dopamine uptake involved in synaptic transmission', 'regulation of gene expression', 'regulation of morphogenesis of a branching structure', 'regulation of semaphorin-plexin signaling pathway', 'regulation of stem cell differentiation', 'signal transduction', 'sympathetic nervous system development', 'ureteric bud formation']['adult locomotory behavior', 'branching involved in ureteric bud morphogenesis', 'commissural neuron axon guidance', 'dorsal spinal cord development', 'embryonic organ development', 'enteric nervous system development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'metanephros development', 'mRNA stabilization', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of neuron apoptotic process', 'nervous system development', 'neural crest cell migration', 'neuron projection development', 'organ induction', 'peripheral nervous system development', 'peristalsis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of dopamine secretion', 'positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis', 'positive regulation of monooxygenase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of ureteric bud formation', 'postganglionic parasympathetic fiber development', 'postsynaptic membrane organization', 'regulation of dopamine uptake involved in synaptic transmission', 'regulation of gene expression', 'regulation of morphogenesis of a branching structure', 'regulation of semaphorin-plexin signaling pathway', 'regulation of stem cell differentiation', 'signal transduction', 'sympathetic nervous system development', 'ureteric bud formation']
Stimulator of interferon genes protein
148
Stimulator of interferon genes protein
148
4.7
64
0.33
Q86WV6Q86WV6['activation of innate immune response', 'autophagosome assembly', 'cellular response to exogenous dsRNA', 'cellular response to interferon-beta', 'cellular response to organic cyclic compound', 'defense response to virus', 'innate immune response', 'positive regulation of defense response to virus by host', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of interferon-beta production', 'positive regulation of macroautophagy', 'positive regulation of protein binding', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of type I interferon production', 'positive regulation of type I interferon-mediated signaling pathway', 'protein complex oligomerization', 'regulation of inflammatory response', 'reticulophagy']['activation of innate immune response', 'autophagosome assembly', 'cellular response to exogenous dsRNA', 'cellular response to interferon-beta', 'cellular response to organic cyclic compound', 'defense response to virus', 'innate immune response', 'positive regulation of defense response to virus by host', 'positive regulation of DNA-binding transcription factor activity', 'positive regulation of interferon-beta production', 'positive regulation of macroautophagy', 'positive regulation of protein binding', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of type I interferon production', 'positive regulation of type I interferon-mediated signaling pathway', 'protein complex oligomerization', 'regulation of inflammatory response', 'reticulophagy']
Protein arginine N-methyltransferase 5
196
Protein arginine N-methyltransferase 5
622
9.2
70
0.16
O14744O14744['chromatin organization', 'circadian regulation of gene expression', 'DNA-templated transcription, termination', 'endothelial cell activation', 'Golgi ribbon formation', 'histone arginine methylation', 'histone H4-R3 methylation', 'liver regeneration', 'negative regulation of cell differentiation', 'peptidyl-arginine methylation', 'peptidyl-arginine N-methylation', 'positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway', 'positive regulation of mRNA splicing, via spliceosome', 'positive regulation of oligodendrocyte differentiation', 'regulation of DNA methylation', 'regulation of ERK1 and ERK2 cascade', 'regulation of mitotic nuclear division', 'regulation of signal transduction by p53 class mediator', 'regulation of transcription, DNA-templated', 'spliceosomal snRNP assembly']['chromatin organization', 'circadian regulation of gene expression', 'DNA-templated transcription, termination', 'endothelial cell activation', 'Golgi ribbon formation', 'histone arginine methylation', 'histone H4-R3 methylation', 'liver regeneration', 'negative regulation of cell differentiation', 'peptidyl-arginine methylation', 'peptidyl-arginine N-methylation', 'positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway', 'positive regulation of mRNA splicing, via spliceosome', 'positive regulation of oligodendrocyte differentiation', 'regulation of DNA methylation', 'regulation of ERK1 and ERK2 cascade', 'regulation of mitotic nuclear division', 'regulation of signal transduction by p53 class mediator', 'regulation of transcription, DNA-templated', 'spliceosomal snRNP assembly']
Endophilin-B1
241
Endophilin-B1
241
7.7
70
0.19
Q9Y371Q9Y371['apoptotic process', 'autophagic cell death', 'autophagy', 'cellular response to amino acid starvation', 'cellular response to glucose starvation', 'membrane fission', 'membrane organization', 'positive regulation of autophagosome assembly', 'positive regulation of autophagy', 'positive regulation of membrane tubulation', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of protein-containing complex assembly', 'protein localization to vacuolar membrane', 'receptor catabolic process', 'regulation of cytokinesis', 'regulation of macroautophagy', 'regulation of protein stability']['apoptotic process', 'autophagic cell death', 'autophagy', 'cellular response to amino acid starvation', 'cellular response to glucose starvation', 'membrane fission', 'membrane organization', 'positive regulation of autophagosome assembly', 'positive regulation of autophagy', 'positive regulation of membrane tubulation', 'positive regulation of protein targeting to mitochondrion', 'positive regulation of protein-containing complex assembly', 'protein localization to vacuolar membrane', 'receptor catabolic process', 'regulation of cytokinesis', 'regulation of macroautophagy', 'regulation of protein stability']
Phosphatidylinositol 4-kinase alpha
1611
Tetratricopeptide repeat protein 7B
423
8.2
74
0.16
P42356Q86TV6['modulation by host of viral process', 'phosphatidylinositol biosynthetic process', 'phosphatidylinositol phosphate biosynthetic process', 'phosphatidylinositol-mediated signaling', 'phosphorylation', 'reorganization of cellular membranes to establish viral sites of replication', 'signal transduction']['phosphatidylinositol phosphate biosynthetic process', 'protein localization to plasma membrane']
Glial cell line-derived neurotrophic factor
178
Glial cell line-derived neurotrophic factor
179
9.9
62
0.16
P39905P39905['adult locomotory behavior', 'branching involved in ureteric bud morphogenesis', 'commissural neuron axon guidance', 'dorsal spinal cord development', 'embryonic organ development', 'enteric nervous system development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'metanephros development', 'mRNA stabilization', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of neuron apoptotic process', 'nervous system development', 'neural crest cell migration', 'neuron projection development', 'organ induction', 'peripheral nervous system development', 'peristalsis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of dopamine secretion', 'positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis', 'positive regulation of monooxygenase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of ureteric bud formation', 'postganglionic parasympathetic fiber development', 'postsynaptic membrane organization', 'regulation of dopamine uptake involved in synaptic transmission', 'regulation of gene expression', 'regulation of morphogenesis of a branching structure', 'regulation of semaphorin-plexin signaling pathway', 'regulation of stem cell differentiation', 'signal transduction', 'sympathetic nervous system development', 'ureteric bud formation']['adult locomotory behavior', 'branching involved in ureteric bud morphogenesis', 'commissural neuron axon guidance', 'dorsal spinal cord development', 'embryonic organ development', 'enteric nervous system development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'metanephros development', 'mRNA stabilization', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of neuron apoptotic process', 'nervous system development', 'neural crest cell migration', 'neuron projection development', 'organ induction', 'peripheral nervous system development', 'peristalsis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of dopamine secretion', 'positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis', 'positive regulation of monooxygenase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of ureteric bud formation', 'postganglionic parasympathetic fiber development', 'postsynaptic membrane organization', 'regulation of dopamine uptake involved in synaptic transmission', 'regulation of gene expression', 'regulation of morphogenesis of a branching structure', 'regulation of semaphorin-plexin signaling pathway', 'regulation of stem cell differentiation', 'signal transduction', 'sympathetic nervous system development', 'ureteric bud formation']
Clathrin heavy chain 1
1565
Clathrin light chain B
198
8.6
63
0.18
P49951P04975['amyloid-beta clearance by transcytosis', 'autophagy', 'cell division', 'clathrin coat assembly', 'clathrin-dependent endocytosis', 'intracellular protein transport', 'mitotic cell cycle', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of protein localization to plasma membrane', 'receptor internalization', 'receptor-mediated endocytosis', 'regulation of mitotic spindle organization', 'retrograde transport, endosome to Golgi', 'transferrin transport']['clathrin-dependent endocytosis', 'intracellular protein transport']
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
727
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
112
9.2
nan
nan
P15690P23934['apoptotic mitochondrial changes', 'ATP metabolic process', 'cellular respiration', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'reactive oxygen species metabolic process', 'regulation of mitochondrial membrane potential']['mitochondrial electron transport, NADH to ubiquinone']
Potassium voltage-gated channel subfamily D member 2
132
Potassium voltage-gated channel subfamily D member 2
111
3.6
66
0.42
A0A6P6DHQ6A0A6P6DHQ6['protein homooligomerization', 'regulation of ion transmembrane transport']['protein homooligomerization', 'regulation of ion transmembrane transport']
Ribosome maturation protein SBDS
210
Elongation factor-like GTPase 1
934
7.4
73
0.19
Q9Y3A5Q7Z2Z2['bone marrow development', 'bone mineralization', 'hematopoietic progenitor cell differentiation', 'inner cell mass cell proliferation', 'leukocyte chemotaxis', 'mature ribosome assembly', 'mitotic spindle organization', 'rRNA processing']['GTP metabolic process', 'mature ribosome assembly']
Sodium channel subunit beta-4
58
Sodium channel protein type 1 subunit alpha
919
2.1
53
0.91
Q8IWT1P35498['AV node cell action potential', 'cardiac muscle cell action potential involved in contraction', 'cardiac muscle contraction', 'establishment of localization in cell', 'membrane depolarization during cardiac muscle cell action potential', 'positive regulation of sodium ion transport', 'regulation of heart rate by cardiac conduction', 'regulation of sodium ion transmembrane transporter activity', 'regulation of ventricular cardiac muscle cell membrane repolarization', 'sodium ion transmembrane transport', 'sodium ion transport']['adult walking behavior', 'cardiac muscle cell action potential involved in contraction', 'detection of mechanical stimulus involved in sensory perception of pain', 'establishment of localization in cell', 'membrane depolarization during action potential', 'neuromuscular process controlling posture', 'neuronal action potential', 'neuronal action potential propagation', 'regulation of ion transmembrane transport', 'sodium ion transmembrane transport', 'sodium ion transport']
GATOR complex protein NPRL2
348
GATOR complex protein NPRL3
343
5.1
57
0.34
Q8WTW4Q12980['cellular response to amino acid starvation', 'negative regulation of kinase activity', 'negative regulation of TOR signaling', 'negative regulation of TORC1 signaling', 'positive regulation of autophagy']['aorta morphogenesis', 'cardiac muscle tissue development', 'cellular response to amino acid starvation', 'negative regulation of TOR signaling', 'negative regulation of TORC1 signaling', 'positive regulation of autophagy', 'roof of mouth development', 'TORC1 signaling', 'ventricular septum development']
C-C motif chemokine 15
53
C-C chemokine receptor type 1
273
8.2
69
0.18
Q16663P32246['cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'signal transduction']['calcium ion transport', 'calcium-mediated signaling', 'cell adhesion', 'cell chemotaxis', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'dendritic cell chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'immune response', 'inflammatory response', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'positive regulation of calcium ion transport', 'positive regulation of cell migration', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of monocyte chemotaxis', 'positive regulation of osteoclast differentiation', 'response to wounding']
THO complex subunit 2
503
THO complex subunit 3
261
7.2
88
0.16
Q8NI27Q96J01['blastocyst development', 'cell morphogenesis', 'generation of neurons', 'mRNA export from nucleus', 'mRNA processing', 'negative regulation of neuron projection development', 'neuron development', 'poly(A)+ mRNA export from nucleus', 'regulation of gene expression', 'regulation of mRNA export from nucleus', 'RNA splicing', 'stem cell division', 'viral mRNA export from host cell nucleus']['mRNA export from nucleus', 'mRNA processing', 'RNA splicing', 'viral mRNA export from host cell nucleus']
Diacylglycerol O-acyltransferase 1
262
Diacylglycerol O-acyltransferase 1
68
5.1
65
0.3
O75907O75907['diacylglycerol metabolic process', 'fatty acid homeostasis', 'lipid storage', 'long-chain fatty-acyl-CoA metabolic process', 'monoacylglycerol biosynthetic process', 'triglyceride biosynthetic process', 'triglyceride metabolic process', 'very-low-density lipoprotein particle assembly']['diacylglycerol metabolic process', 'fatty acid homeostasis', 'lipid storage', 'long-chain fatty-acyl-CoA metabolic process', 'monoacylglycerol biosynthetic process', 'triglyceride biosynthetic process', 'triglyceride metabolic process', 'very-low-density lipoprotein particle assembly']
Insulin receptor
712
Insulin receptor
712
9.9
51
0.2
P06213P06213['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell']['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell']
Tapasin
115
Protein disulfide-isomerase A3
60
7.4
64
0.21
O15533P30101['antigen processing and presentation of endogenous peptide antigen via MHC class I', 'immune response', 'MHC class I protein complex assembly', 'MHC class Ib protein complex assembly', 'peptide antigen assembly with MHC class I protein complex', 'peptide antigen stabilization', 'protein-containing complex assembly', 'regulation of gene expression', 'regulation of immune response', 'regulation of protein complex stability', 'retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum']['cellular response to interleukin-7', 'extrinsic apoptotic signaling pathway', 'peptide antigen assembly with MHC class I protein complex', 'positive regulation of extrinsic apoptotic signaling pathway', 'protein folding', 'protein folding in endoplasmic reticulum', 'response to endoplasmic reticulum stress']
Origin recognition complex subunit 4
194
Origin recognition complex subunit 5
171
9.9
64
0.16
O43929O43913['DNA replication initiation']['DNA replication', 'DNA replication initiation', 'regulation of DNA replication']
ER membrane protein complex subunit 5
57
ER membrane protein complex subunit 6
29
10.0
88
0.11
Q8N4V1Q9BV81['copper ion transport', 'magnesium ion transport', 'protein insertion into ER membrane by stop-transfer membrane-anchor sequence', 'tail-anchored membrane protein insertion into ER membrane']['autophagosome assembly', 'protein insertion into ER membrane by stop-transfer membrane-anchor sequence', 'tail-anchored membrane protein insertion into ER membrane']
C-C motif chemokine 15
77
C-C chemokine receptor type 1
24
9.7
66
0.16
Q16663P32246['cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'signal transduction']['calcium ion transport', 'calcium-mediated signaling', 'cell adhesion', 'cell chemotaxis', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'dendritic cell chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'immune response', 'inflammatory response', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'positive regulation of calcium ion transport', 'positive regulation of cell migration', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of monocyte chemotaxis', 'positive regulation of osteoclast differentiation', 'response to wounding']
Igh protein
478
Immunoglobulin J chain
123
9.0
65
0.17
Q99M22P01592[]['adaptive immune response', 'antibacterial humoral response', 'glomerular filtration', 'humoral immune response', 'innate immune response', 'positive regulation of respiratory burst', 'protein-containing complex assembly']
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
180
7.4
92
0.15
P49821P19404['aerobic respiration', 'mitochondrial ATP synthesis coupled electron transport', 'mitochondrial electron transport, NADH to ubiquinone', 'proton motive force-driven mitochondrial ATP synthesis']['aerobic respiration', 'cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development', 'proton motive force-driven mitochondrial ATP synthesis']
Mucin-2
1088
Mucin-2
1082
10.0
78
0.13
A0A0G2JR65A0A0G2JR65[][]
Muscarinic acetylcholine receptor M2
443
Guanine nucleotide-binding protein G(o) subunit alpha
351
8.7
67
0.17
P08172P09471['adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'chemical synaptic transmission', 'G protein-coupled acetylcholine receptor signaling pathway', 'G protein-coupled receptor signaling pathway', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'nervous system development', 'phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway', 'regulation of heart contraction', 'regulation of smooth muscle contraction', 'regulation of synaptic vesicle exocytosis', 'response to virus']['adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'dopamine receptor signaling pathway', 'muscle contraction']
B(0,+)-type amino acid transporter 1
144
neutral and basic amino acid transport protein rBAT
114
2.1
54
0.89
A0A6P3EL78A0A6P7DVK7[]['carbohydrate metabolic process']
Sodium channel subunit beta-2
55
Sodium channel protein type 2 subunit alpha
910
2.1
73
0.66
O60939Q99250['cardiac muscle cell action potential involved in contraction', 'cardiac muscle contraction', 'chemical synaptic transmission', 'gene expression', 'membrane depolarization during cardiac muscle cell action potential', 'nervous system development', 'regulation of atrial cardiac muscle cell membrane depolarization', 'regulation of heart rate by cardiac conduction', 'regulation of sodium ion transmembrane transporter activity', 'response to heat', 'response to pyrethroid', 'sodium ion transmembrane transport']['cellular response to hypoxia', 'intrinsic apoptotic signaling pathway in response to osmotic stress', 'membrane depolarization during action potential', 'memory', 'myelination', 'nervous system development', 'neuron apoptotic process', 'neuronal action potential', 'regulation of ion transmembrane transport', 'sodium ion transmembrane transport', 'sodium ion transport']
Sodium channel subunit beta-1
181
Sodium channel protein type 3 subunit alpha
1199
8.7
62
0.19
Q07699Q9NY46['axon guidance', 'cardiac conduction', 'cardiac muscle cell action potential involved in contraction', 'cardiac muscle contraction', 'cell adhesion', 'corticospinal neuron axon guidance', 'locomotion', 'membrane depolarization', 'membrane depolarization during cardiac muscle cell action potential', 'membrane depolarization during Purkinje myocyte cell action potential', 'neuronal action potential propagation', 'positive regulation of neuron projection development', 'positive regulation of sodium ion transport', 'regulation of atrial cardiac muscle cell membrane depolarization', 'regulation of heart rate by cardiac conduction', 'regulation of sodium ion transmembrane transporter activity', 'regulation of ventricular cardiac muscle cell membrane repolarization', 'sodium ion transmembrane transport']['membrane depolarization during action potential', 'neuronal action potential', 'regulation of ion transmembrane transport', 'sodium ion transmembrane transport', 'sodium ion transport']
Neuronal acetylcholine receptor subunit beta-2
262
Neuronal acetylcholine receptor subunit beta-2
262
8.5
65
0.18
P17787P17787['acetylcholine receptor signaling pathway', 'associative learning', 'B cell activation', 'behavioral response to nicotine', 'calcium ion transport', 'central nervous system projection neuron axonogenesis', 'chemical synaptic transmission', 'cognition', 'ion transmembrane transport', 'ion transport', 'lateral geniculate nucleus development', 'learning', 'locomotory behavior', 'membrane depolarization', 'memory', 'negative regulation of action potential', 'nervous system process', 'optic nerve morphogenesis', 'positive regulation of B cell proliferation', 'positive regulation of dopamine secretion', 'regulation of circadian sleep/wake cycle, REM sleep', 'regulation of dendrite morphogenesis', 'regulation of dopamine metabolic process', 'regulation of dopamine secretion', 'regulation of membrane potential', 'regulation of synapse assembly', 'regulation of synaptic transmission, dopaminergic', 'response to acetylcholine', 'response to cocaine', 'response to ethanol', 'response to hypoxia', 'response to nicotine', 'sensory perception of pain', 'sensory perception of sound', 'signal transduction', 'smooth muscle contraction', 'social behavior', 'synaptic transmission involved in micturition', 'synaptic transmission, cholinergic', 'vestibulocochlear nerve development', 'visual learning', 'visual perception']['acetylcholine receptor signaling pathway', 'associative learning', 'B cell activation', 'behavioral response to nicotine', 'calcium ion transport', 'central nervous system projection neuron axonogenesis', 'chemical synaptic transmission', 'cognition', 'ion transmembrane transport', 'ion transport', 'lateral geniculate nucleus development', 'learning', 'locomotory behavior', 'membrane depolarization', 'memory', 'negative regulation of action potential', 'nervous system process', 'optic nerve morphogenesis', 'positive regulation of B cell proliferation', 'positive regulation of dopamine secretion', 'regulation of circadian sleep/wake cycle, REM sleep', 'regulation of dendrite morphogenesis', 'regulation of dopamine metabolic process', 'regulation of dopamine secretion', 'regulation of membrane potential', 'regulation of synapse assembly', 'regulation of synaptic transmission, dopaminergic', 'response to acetylcholine', 'response to cocaine', 'response to ethanol', 'response to hypoxia', 'response to nicotine', 'sensory perception of pain', 'sensory perception of sound', 'signal transduction', 'smooth muscle contraction', 'social behavior', 'synaptic transmission involved in micturition', 'synaptic transmission, cholinergic', 'vestibulocochlear nerve development', 'visual learning', 'visual perception']
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
188
Transcription factor SPT20 homolog
237
6.8
71
0.21
O75529Q8NEM7['histone acetylation', 'histone H3 acetylation', 'monoubiquitinated histone deubiquitination', 'monoubiquitinated histone H2A deubiquitination', 'positive regulation of transcription, DNA-templated', 'regulation of DNA repair', 'regulation of RNA splicing', 'regulation of somatic stem cell population maintenance', 'regulation of transcription by RNA polymerase II', 'regulation of transcription, DNA-templated', 'transcription by RNA polymerase II']['autophagy', 'gastrulation', 'histone H3 acetylation', 'monoubiquitinated histone deubiquitination', 'monoubiquitinated histone H2A deubiquitination', 'positive regulation of transcription, DNA-templated', 'regulation of DNA repair', 'regulation of RNA splicing', 'regulation of transcription by RNA polymerase II']
Glutamate receptor
549
Protein cornichon homolog 2
9
6.8
77
0.19
G5E8H1O35089[]['localization within membrane', 'negative regulation of anterograde synaptic vesicle transport', 'negative regulation of receptor localization to synapse', 'regulation of AMPA receptor activity', 'regulation of membrane potential', 'regulation of NMDA receptor activity', 'regulation of postsynaptic neurotransmitter receptor activity', 'synaptic transmission, glutamatergic', 'vesicle-mediated transport']
Insulin-like growth factor-binding protein 3
240
Insulin-like growth factor I
96
6.8
69
0.21
P17936P05019['apoptotic process', 'MAPK cascade', 'negative regulation of cell population proliferation', 'negative regulation of protein phosphorylation', 'negative regulation of signal transduction', 'negative regulation of smooth muscle cell migration', 'negative regulation of smooth muscle cell proliferation', 'osteoblast differentiation', 'positive regulation of apoptotic process', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of myoblast differentiation', 'protein phosphorylation', 'regulation of cell growth', 'regulation of glucose metabolic process', 'regulation of insulin-like growth factor receptor signaling pathway', 'type B pancreatic cell proliferation']['activation of protein kinase B activity', 'bone mineralization involved in bone maturation', 'cell activation', 'cell population proliferation', 'cellular response to amyloid-beta', 'ERK1 and ERK2 cascade', 'glycolate metabolic process', 'insulin-like growth factor receptor signaling pathway', 'muscle hypertrophy', 'muscle organ development', 'myoblast differentiation', 'myoblast proliferation', 'myotube cell development', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of gene expression', 'negative regulation of interleukin-1 beta production', 'negative regulation of neuroinflammatory response', 'negative regulation of oocyte development', 'negative regulation of release of cytochrome c from mitochondria', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of tumor necrosis factor production', 'negative regulation of vascular associated smooth muscle cell apoptotic process', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol-mediated signaling', 'positive regulation of activated T cell proliferation', 'positive regulation of calcineurin-NFAT signaling cascade', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of DNA binding', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Ras protein signal transduction', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of trophectodermal cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase B signaling', 'protein stabilization', 'proteoglycan biosynthetic process', 'Ras protein signal transduction', 'regulation of gene expression', 'regulation of multicellular organism growth', 'regulation of protein phosphorylation', 'response to heat', 'signal transduction', 'skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration', 'skeletal system development', 'wound healing']
Ig kappa-b4 chain C region
103
IgG heavy chain VDJ region
133
2.0
nan
nan
P01840A0A1Y1B8B1[][]
Centromere protein T
486
Centromere protein W
47
9.9
62
0.16
Q96BT3Q5EE01['cell division', 'chromosome organization', 'chromosome segregation', 'kinetochore assembly', 'mitotic cell cycle']['cell division', 'CENP-A containing chromatin assembly', 'chromosome organization', 'chromosome segregation', 'kinetochore assembly', 'mitotic cell cycle']
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
95
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
95
8.3
83
0.14
Q9H1K1Q9H1K1['cellular iron ion homeostasis', 'iron-sulfur cluster assembly', 'negative regulation of iron ion import across plasma membrane', 'positive regulation of aconitate hydratase activity', 'positive regulation of mitochondrial electron transport, NADH to ubiquinone']['cellular iron ion homeostasis', 'iron-sulfur cluster assembly', 'negative regulation of iron ion import across plasma membrane', 'positive regulation of aconitate hydratase activity', 'positive regulation of mitochondrial electron transport, NADH to ubiquinone']
Splicing factor 3B subunit 1
677
PHD finger-like domain-containing protein 5A
11
8.5
61
0.19
O75533Q7RTV0['chromatin remodeling', 'mRNA splicing, via spliceosome', 'positive regulation of histone acetylation', 'positive regulation of transcription by RNA polymerase I', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase III', 'RNA splicing', 'RNA splicing, via transesterification reactions', 'spliceosomal complex assembly', 'U2-type prespliceosome assembly']['mRNA splicing, via spliceosome', 'positive regulation of transcription, DNA-templated', 'stem cell differentiation', 'U2-type prespliceosome assembly']
Glial cell line-derived neurotrophic factor
210
Glial cell line-derived neurotrophic factor
178
8.5
nan
nan
P39905P39905['adult locomotory behavior', 'branching involved in ureteric bud morphogenesis', 'commissural neuron axon guidance', 'dorsal spinal cord development', 'embryonic organ development', 'enteric nervous system development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'metanephros development', 'mRNA stabilization', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of neuron apoptotic process', 'nervous system development', 'neural crest cell migration', 'neuron projection development', 'organ induction', 'peripheral nervous system development', 'peristalsis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of dopamine secretion', 'positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis', 'positive regulation of monooxygenase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of ureteric bud formation', 'postganglionic parasympathetic fiber development', 'postsynaptic membrane organization', 'regulation of dopamine uptake involved in synaptic transmission', 'regulation of gene expression', 'regulation of morphogenesis of a branching structure', 'regulation of semaphorin-plexin signaling pathway', 'regulation of stem cell differentiation', 'signal transduction', 'sympathetic nervous system development', 'ureteric bud formation']['adult locomotory behavior', 'branching involved in ureteric bud morphogenesis', 'commissural neuron axon guidance', 'dorsal spinal cord development', 'embryonic organ development', 'enteric nervous system development', 'mesenchymal to epithelial transition involved in metanephros morphogenesis', 'metanephros development', 'mRNA stabilization', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway in absence of ligand', 'negative regulation of neuron apoptotic process', 'nervous system development', 'neural crest cell migration', 'neuron projection development', 'organ induction', 'peripheral nervous system development', 'peristalsis', 'positive regulation of branching involved in ureteric bud morphogenesis', 'positive regulation of cell differentiation', 'positive regulation of cell population proliferation', 'positive regulation of dopamine secretion', 'positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis', 'positive regulation of monooxygenase activity', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of ureteric bud formation', 'postganglionic parasympathetic fiber development', 'postsynaptic membrane organization', 'regulation of dopamine uptake involved in synaptic transmission', 'regulation of gene expression', 'regulation of morphogenesis of a branching structure', 'regulation of semaphorin-plexin signaling pathway', 'regulation of stem cell differentiation', 'signal transduction', 'sympathetic nervous system development', 'ureteric bud formation']
Clathrin heavy chain
1573
Clathrin light chain
178
8.6
67
0.17
C0MHR2F1S398['clathrin coat assembly', 'intracellular protein transport', 'mitotic cell cycle', 'receptor-mediated endocytosis']['clathrin-dependent endocytosis', 'intracellular protein transport']
Glutamate receptor
610
Glutamate receptor 1
603
6.0
81
0.21
G5E8H1P23818[]['cellular response to ammonium ion', 'chemical synaptic transmission', 'long-term memory', 'long-term synaptic depression', 'modulation of chemical synaptic transmission', 'neuronal action potential', 'positive regulation of membrane potential', 'positive regulation of synaptic transmission', 'receptor internalization', 'regulation of postsynaptic membrane potential', 'regulation of receptor recycling', 'regulation of synaptic plasticity', 'response to toxic substance']
Insulin receptor
709
Insulin receptor
712
9.3
43
0.25
P06213P06213['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell']['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell']
Centromere protein L
286
Centromere protein N
293
9.8
61
0.17
Q8N0S6Q96H22[]['chromosome segregation', 'kinetochore assembly']
Volume-regulated anion channel subunit LRRC8D
809
Volume-regulated anion channel subunit LRRC8D
687
9.2
74
0.15
Q7L1W4Q7L1W4['anion transmembrane transport', 'aspartate transmembrane transport', 'cellular glucose homeostasis', 'cellular response to osmotic stress', 'protein hexamerization', 'taurine transport']['anion transmembrane transport', 'aspartate transmembrane transport', 'cellular glucose homeostasis', 'cellular response to osmotic stress', 'protein hexamerization', 'taurine transport']
Transforming growth factor beta-1 proprotein
33
Transforming growth factor beta activator LRRC33
219
2.0
59
0.83
P01137Q86YC3['aortic valve morphogenesis', 'ATP biosynthetic process', 'BMP signaling pathway', 'cell migration', 'cell-cell junction organization', 'cellular response to organic cyclic compound', 'cellular response to transforming growth factor beta stimulus', 'chondrocyte differentiation', 'common-partner SMAD protein phosphorylation', 'connective tissue replacement involved in inflammatory response wound healing', 'embryonic liver development', 'epidermal growth factor receptor signaling pathway', 'epithelial to mesenchymal transition', 'extracellular matrix assembly', 'extrinsic apoptotic signaling pathway', 'heart development', 'heart valve morphogenesis', 'hematopoietic progenitor cell differentiation', 'hyaluronan catabolic process', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymph node development', 'macrophage derived foam cell differentiation', 'MAPK cascade', 'membrane protein intracellular domain proteolysis', 'negative regulation of biomineral tissue development', 'negative regulation of blood vessel endothelial cell migration', 'negative regulation of cell cycle', 'negative regulation of cell differentiation', 'negative regulation of cell growth', 'negative regulation of cell population proliferation', 'negative regulation of cell-cell adhesion', 'negative regulation of cytolysis', 'negative regulation of epithelial cell proliferation', 'negative regulation of extracellular matrix disassembly', 'negative regulation of fat cell differentiation', 'negative regulation of gene expression', 'negative regulation of hyaluronan biosynthetic process', 'negative regulation of macrophage cytokine production', 'negative regulation of miRNA maturation', 'negative regulation of miRNA transcription', 'negative regulation of miRNA-mediated gene silencing', 'negative regulation of myoblast differentiation', 'negative regulation of protein localization to plasma membrane', 'negative regulation of protein phosphorylation', 'negative regulation of skeletal muscle tissue development', 'negative regulation of transcription, DNA-templated', 'neural tube closure', 'neural tube development', 'ossification involved in bone remodeling', 'pathway-restricted SMAD protein phosphorylation', 'phosphate-containing compound metabolic process', 'positive regulation of blood vessel endothelial cell migration', 'positive regulation of bone mineralization', 'positive regulation of canonical Wnt signaling pathway', 'positive regulation of cardiac muscle cell differentiation', 'positive regulation of cell division', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of chemotaxis', 'positive regulation of collagen biosynthetic process', 'positive regulation of epithelial to mesenchymal transition', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of extracellular matrix assembly', 'positive regulation of fibroblast migration', 'positive regulation of gene expression', 'positive regulation of interleukin-17 production', 'positive regulation of isotype switching to IgA isotypes', 'positive regulation of MAP kinase activity', 'positive regulation of microglia differentiation', 'positive regulation of miRNA maturation', 'positive regulation of miRNA transcription', 'positive regulation of NAD+ ADP-ribosyltransferase activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'positive regulation of peptidyl-serine phosphorylation', 'positive regulation of peptidyl-threonine phosphorylation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase activity', 'positive regulation of protein dephosphorylation', 'positive regulation of protein import into nucleus', 'positive regulation of protein kinase B signaling', 'positive regulation of protein localization to nucleus', 'positive regulation of protein metabolic process', 'positive regulation of protein phosphorylation', 'positive regulation of protein secretion', 'positive regulation of protein-containing complex assembly', 'positive regulation of receptor signaling pathway via STAT', 'positive regulation of SMAD protein signal transduction', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of superoxide anion generation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of vascular endothelial growth factor production', 'positive regulation of vascular permeability', 'protein export from nucleus', 'protein kinase B signaling', 'protein phosphorylation', 'receptor catabolic process', 'regulation of binding', 'regulation of blood vessel remodeling', 'regulation of cell migration', 'regulation of cell population proliferation', 'regulation of DNA binding', 'regulation of protein import into nucleus', 'regulation of SMAD protein signal transduction', 'regulation of striated muscle tissue development', 'regulation of transforming growth factor beta receptor signaling pathway', 'response to cholesterol', 'response to estradiol', 'response to progesterone', 'response to wounding', 'salivary gland morphogenesis', 'SMAD protein complex assembly', 'SMAD protein signal transduction', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta receptor signaling pathway involved in heart development', 'vasculogenesis', 'ventricular cardiac muscle tissue morphogenesis']['immune response', 'inflammatory response', 'microglia development', 'sequestering of TGFbeta in extracellular matrix', 'superoxide metabolic process', 'transforming growth factor beta receptor signaling pathway', 'transforming growth factor beta1 activation']
Large neutral amino acids transporter small subunit 2
154
4F2 cell-surface antigen heavy chain
210
2.0
46
1.07
Q9UHI5P08195['amino acid import across plasma membrane', 'amino acid transport', 'glycine transport', 'L-alanine import across plasma membrane', 'L-leucine import across plasma membrane', 'leucine import across plasma membrane', 'leucine transport', 'metal ion homeostasis', 'neutral amino acid transport', 'proline transmembrane transport', 'response to toxic substance', 'thyroid hormone transport', 'transport across blood-brain barrier', 'tryptophan transport', 'valine transport']['amino acid transport', 'calcium ion transport', 'carbohydrate metabolic process', 'L-alanine import across plasma membrane', 'L-leucine import across plasma membrane', 'leucine import across plasma membrane', 'leucine transport', 'phenylalanine transport', 'response to exogenous dsRNA', 'tryptophan transport', 'viral entry into host cell']
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
277
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
72
9.3
72
0.15
P46977P61803['co-translational protein modification', 'post-translational protein modification', 'protein N-linked glycosylation', 'protein N-linked glycosylation via asparagine']['apoptotic process', 'blastocyst development', 'negative regulation of apoptotic process', 'protein glycosylation', 'protein N-linked glycosylation', 'protein N-linked glycosylation via asparagine', 'regulation of protein stability', 'response to nutrient', 'response to xenobiotic stimulus']
4F2 cell-surface antigen heavy chain
211
Cystine/glutamate transporter
158
2.0
40
1.23
J3KPF3Q9UPY5['amino acid transport', 'carbohydrate metabolic process']['adult behavior', 'cellular response to oxidative stress', 'dipeptide import across plasma membrane', 'glutamate homeostasis', 'glutathione metabolic process', 'glutathione transmembrane transport', 'L-glutamate import across plasma membrane', 'lens fiber cell differentiation', 'limb development', 'lung alveolus development', 'modulation of chemical synaptic transmission', 'negative regulation of oxidative stress-induced neuron death', 'platelet aggregation', 'regulation of AMPA glutamate receptor clustering', 'regulation of cell population proliferation', 'regulation of cysteine metabolic process', 'regulation of glutamate metabolic process', 'regulation of glutathione biosynthetic process', 'regulation of melanin biosynthetic process', 'regulation of neutrophil apoptotic process', 'regulation of protein transport', 'regulation of synapse organization', 'response to nicotine', 'response to organic cyclic compound', 'response to redox state', 'response to toxic substance', 'striatum development', 'ventricular system development', 'visual learning']
COP9 signalosome complex subunit 3
154
COP9 signalosome complex subunit 8
20
9.3
68
0.16
Q9UNS2Q99627['in utero embryonic development', 'protein deneddylation', 'protein neddylation', 'regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator', 'regulation of protein neddylation', 'response to light stimulus', 'signal transduction', 'ubiquitin-dependent protein catabolic process']['activation of NF-kappaB-inducing kinase activity', 'COP9 signalosome assembly', 'negative regulation of cell population proliferation', 'protein deneddylation', 'protein neddylation', 'protein phosphorylation', 'regulation of protein neddylation']
Immunoglobulin heavy constant mu
452
Immunoglobulin J chain
35
8.6
68
0.17
P01871P01591['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response', 'antibacterial humoral response', 'glomerular filtration', 'humoral immune response', 'immune response', 'innate immune response', 'positive regulation of respiratory burst', 'protein-containing complex assembly', 'retina homeostasis']
C-C motif chemokine 15
77
C-C chemokine receptor type 1
273
9.7
71
0.15
Q16663P32246['cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'signal transduction']['calcium ion transport', 'calcium-mediated signaling', 'cell adhesion', 'cell chemotaxis', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'dendritic cell chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'immune response', 'inflammatory response', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'positive regulation of calcium ion transport', 'positive regulation of cell migration', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of monocyte chemotaxis', 'positive regulation of osteoclast differentiation', 'response to wounding']
Dynactin subunit 6
129
Dynactin subunit 5
149
7.5
74
0.18
D0G6S1A0A286ZK88['mitotic spindle organization']['aorta development', 'coronary vasculature development', 'ventricular septum development']
Insulin-like growth factor-binding protein 3
213
Insulin-like growth factor I
54
6.8
64
0.23
P17936P05019['apoptotic process', 'MAPK cascade', 'negative regulation of cell population proliferation', 'negative regulation of protein phosphorylation', 'negative regulation of signal transduction', 'negative regulation of smooth muscle cell migration', 'negative regulation of smooth muscle cell proliferation', 'osteoblast differentiation', 'positive regulation of apoptotic process', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of myoblast differentiation', 'protein phosphorylation', 'regulation of cell growth', 'regulation of glucose metabolic process', 'regulation of insulin-like growth factor receptor signaling pathway', 'type B pancreatic cell proliferation']['activation of protein kinase B activity', 'bone mineralization involved in bone maturation', 'cell activation', 'cell population proliferation', 'cellular response to amyloid-beta', 'ERK1 and ERK2 cascade', 'glycolate metabolic process', 'insulin-like growth factor receptor signaling pathway', 'muscle hypertrophy', 'muscle organ development', 'myoblast differentiation', 'myoblast proliferation', 'myotube cell development', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of gene expression', 'negative regulation of interleukin-1 beta production', 'negative regulation of neuroinflammatory response', 'negative regulation of oocyte development', 'negative regulation of release of cytochrome c from mitochondria', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of tumor necrosis factor production', 'negative regulation of vascular associated smooth muscle cell apoptotic process', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol-mediated signaling', 'positive regulation of activated T cell proliferation', 'positive regulation of calcineurin-NFAT signaling cascade', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of DNA binding', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Ras protein signal transduction', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of trophectodermal cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase B signaling', 'protein stabilization', 'proteoglycan biosynthetic process', 'Ras protein signal transduction', 'regulation of gene expression', 'regulation of multicellular organism growth', 'regulation of protein phosphorylation', 'response to heat', 'signal transduction', 'skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration', 'skeletal system development', 'wound healing']
DNA-directed RNA polymerase I subunit RPA1
67
DNA-directed RNA polymerase I subunit RPA2
1098
7.0
77
0.19
O95602Q9H9Y6['negative regulation of protein localization to nucleolus']['embryo implantation', 'neural crest formation', 'nucleologenesis', 'rRNA transcription']
C-C motif chemokine 15
54
C-C chemokine receptor type 1
273
9.4
69
0.15
Q16663P32246['cell-cell signaling', 'cellular calcium ion homeostasis', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'G protein-coupled receptor signaling pathway', 'inflammatory response', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'signal transduction']['calcium ion transport', 'calcium-mediated signaling', 'cell adhesion', 'cell chemotaxis', 'cell surface receptor signaling pathway', 'cell-cell signaling', 'cellular calcium ion homeostasis', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'dendritic cell chemotaxis', 'exocytosis', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'immune response', 'inflammatory response', 'negative regulation of bone mineralization', 'negative regulation of gene expression', 'positive regulation of calcium ion transport', 'positive regulation of cell migration', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of monocyte chemotaxis', 'positive regulation of osteoclast differentiation', 'response to wounding']
28S ribosomal protein S16, mitochondrial
26
28S ribosomal protein S25, mitochondrial
139
6.9
50
0.29
P82915P82669['mitochondrial translation']['mitochondrial translation']
Superoxide dismutase [Cu-Zn]
7
Superoxide dismutase [Cu-Zn]
7
9.9
57
0.18
P00441P00441['aging', 'anterograde axonal transport', 'apoptotic process', 'auditory receptor cell stereocilium organization', 'cellular iron ion homeostasis', 'cellular response to ATP', 'cellular response to cadmium ion', 'cellular response to potassium ion', 'ectopic germ cell programmed cell death', 'embryo implantation', 'glutathione metabolic process', 'heart contraction', 'hydrogen peroxide biosynthetic process', 'locomotory behavior', 'muscle cell cellular homeostasis', 'myeloid cell homeostasis', 'negative regulation of cholesterol biosynthetic process', 'negative regulation of developmental process', 'negative regulation of inflammatory response', 'negative regulation of neuron apoptotic process', 'negative regulation of reproductive process', 'neurofilament cytoskeleton organization', 'ovarian follicle development', 'peripheral nervous system myelin maintenance', 'placenta development', 'positive regulation of apoptotic process', 'positive regulation of catalytic activity', 'positive regulation of cytokine production', 'positive regulation of MAPK cascade', 'positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'positive regulation of phagocytosis', 'positive regulation of superoxide anion generation', 'reactive oxygen species metabolic process', 'regulation of blood pressure', 'regulation of GTPase activity', 'regulation of mitochondrial membrane potential', 'regulation of multicellular organism growth', 'regulation of organ growth', 'regulation of protein kinase activity', 'regulation of T cell differentiation in thymus', 'relaxation of vascular associated smooth muscle', 'removal of superoxide radicals', 'response to amphetamine', 'response to antibiotic', 'response to antipsychotic drug', 'response to axon injury', 'response to carbon monoxide', 'response to copper ion', 'response to ethanol', 'response to heat', 'response to hydrogen peroxide', 'response to nutrient levels', 'response to organic substance', 'response to superoxide', 'response to xenobiotic stimulus', 'retina homeostasis', 'retrograde axonal transport', 'sensory perception of sound', 'spermatogenesis', 'superoxide anion generation', 'superoxide metabolic process', 'thymus development', 'transmission of nerve impulse']['aging', 'anterograde axonal transport', 'apoptotic process', 'auditory receptor cell stereocilium organization', 'cellular iron ion homeostasis', 'cellular response to ATP', 'cellular response to cadmium ion', 'cellular response to potassium ion', 'ectopic germ cell programmed cell death', 'embryo implantation', 'glutathione metabolic process', 'heart contraction', 'hydrogen peroxide biosynthetic process', 'locomotory behavior', 'muscle cell cellular homeostasis', 'myeloid cell homeostasis', 'negative regulation of cholesterol biosynthetic process', 'negative regulation of developmental process', 'negative regulation of inflammatory response', 'negative regulation of neuron apoptotic process', 'negative regulation of reproductive process', 'neurofilament cytoskeleton organization', 'ovarian follicle development', 'peripheral nervous system myelin maintenance', 'placenta development', 'positive regulation of apoptotic process', 'positive regulation of catalytic activity', 'positive regulation of cytokine production', 'positive regulation of MAPK cascade', 'positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway', 'positive regulation of phagocytosis', 'positive regulation of superoxide anion generation', 'reactive oxygen species metabolic process', 'regulation of blood pressure', 'regulation of GTPase activity', 'regulation of mitochondrial membrane potential', 'regulation of multicellular organism growth', 'regulation of organ growth', 'regulation of protein kinase activity', 'regulation of T cell differentiation in thymus', 'relaxation of vascular associated smooth muscle', 'removal of superoxide radicals', 'response to amphetamine', 'response to antibiotic', 'response to antipsychotic drug', 'response to axon injury', 'response to carbon monoxide', 'response to copper ion', 'response to ethanol', 'response to heat', 'response to hydrogen peroxide', 'response to nutrient levels', 'response to organic substance', 'response to superoxide', 'response to xenobiotic stimulus', 'retina homeostasis', 'retrograde axonal transport', 'sensory perception of sound', 'spermatogenesis', 'superoxide anion generation', 'superoxide metabolic process', 'thymus development', 'transmission of nerve impulse']
Hepcidin
82
Solute carrier family 40 member 1
326
7.4
76
0.18
P81172Q9NP59['acute-phase response', 'aging', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular iron ion homeostasis', 'cellular response to bile acid', 'cellular response to interleukin-6', 'cellular response to lipopolysaccharide', 'cellular response to tumor necrosis factor', 'cellular response to X-ray', 'defense response to bacterium', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'establishment of localization in cell', 'immune response', 'iron ion transmembrane transport', 'killing of cells of another organism', 'liver regeneration', 'macrophage activation', 'multicellular organismal iron ion homeostasis', 'myeloid cell homeostasis', 'negative regulation of bone resorption', 'negative regulation of inflammatory response', 'negative regulation of intestinal absorption', 'negative regulation of ion transmembrane transporter activity', 'negative regulation of iron export across plasma membrane', 'negative regulation of iron ion transmembrane transport', 'negative regulation of iron ion transmembrane transporter activity', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of macrophage activation', 'positive regulation of protein catabolic process', 'positive regulation of protein polyubiquitination', 'positive regulation of receptor catabolic process', 'positive regulation of receptor internalization', 'positive regulation of transcription by RNA polymerase II', 'protein catabolic process', 'receptor signaling pathway via JAK-STAT', 'response to erythropoietin', 'response to ethanol', 'response to iron ion', 'response to iron ion starvation', 'response to vitamin A', 'response to zinc ion', 'transcription by RNA polymerase II']['apoptotic process', 'cellular iron ion homeostasis', 'endothelium development', 'establishment of localization in cell', 'iron ion export across plasma membrane', 'iron ion homeostasis', 'iron ion transmembrane transport', 'lymphocyte homeostasis', 'multicellular organismal iron ion homeostasis', 'negative regulation of apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of transcription from RNA polymerase II promoter in response to iron', 'spleen trabecula formation', 'transcription by RNA polymerase II']
Mediator of RNA polymerase II transcription subunit 11
90
Mediator of RNA polymerase II transcription subunit 22
112
7.6
62
0.21
Q9P086Q15528['positive regulation of transcription elongation from RNA polymerase II promoter', 'positive regulation of transcription initiation from RNA polymerase II promoter', 'RNA polymerase II preinitiation complex assembly']['positive regulation of transcription elongation from RNA polymerase II promoter', 'positive regulation of transcription initiation from RNA polymerase II promoter', 'RNA polymerase II preinitiation complex assembly']
DNA-directed RNA polymerase III subunit RPC10
25
DNA-directed RNA polymerase III subunit RPC5
70
9.7
60
0.17
Q9Y2Y1Q9NVU0['defense response to virus', 'innate immune response', 'termination of RNA polymerase III transcription', 'transcription by RNA polymerase III', "tRNA 3'-trailer cleavage"]['defense response to virus', 'innate immune response', 'transcription, DNA-templated']
Solute carrier family 12 member 4
781
Solute carrier family 12 member 4
781
9.3
90
0.12
Q9UP95Q9UP95['ammonium import across plasma membrane', 'cell volume homeostasis', 'chemical synaptic transmission', 'chloride ion homeostasis', 'chloride transmembrane transport', 'ion transport', 'potassium ion homeostasis', 'potassium ion import across plasma membrane']['ammonium import across plasma membrane', 'cell volume homeostasis', 'chemical synaptic transmission', 'chloride ion homeostasis', 'chloride transmembrane transport', 'ion transport', 'potassium ion homeostasis', 'potassium ion import across plasma membrane']
Immunoglobulin J chain
37
Immunoglobulin heavy constant mu
452
2.0
68
0.73
P01591P01871['adaptive immune response', 'antibacterial humoral response', 'glomerular filtration', 'humoral immune response', 'immune response', 'innate immune response', 'positive regulation of respiratory burst', 'protein-containing complex assembly', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
382
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
75
9.4
85
0.13
P49821P28331['aerobic respiration', 'mitochondrial ATP synthesis coupled electron transport', 'mitochondrial electron transport, NADH to ubiquinone', 'proton motive force-driven mitochondrial ATP synthesis']['aerobic respiration', 'apoptotic mitochondrial changes', 'ATP metabolic process', 'cellular respiration', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'proton motive force-driven mitochondrial ATP synthesis', 'reactive oxygen species metabolic process', 'regulation of mitochondrial membrane potential']
Voltage-dependent anion-selective channel protein 2
76
Voltage-dependent anion-selective channel protein 2
47
9.4
37
0.29
F1S2F6F1S2F6[][]
Glycoprotein hormones alpha chain
55
Thyrotropin subunit beta
22
9.0
66
0.17
P01215P01222['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['anatomical structure morphogenesis', 'cell-cell signaling', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'response to calcium ion', 'response to estrogen', 'response to vitamin A']
TMEM106B protein
293
TMEM106B protein
254
5.3
59
0.32
Q8N353Q8N353[][]
DNA-directed RNA polymerase III subunit RPC2
924
DNA-directed RNA polymerases I, II, and III subunit RPABC5
45
9.7
92
0.11
Q9NW08P62875['defense response to virus', 'innate immune response', 'positive regulation of innate immune response', 'positive regulation of interferon-beta production', 'transcription, DNA-templated']['regulation of transcription by RNA polymerase I', 'transcription by RNA polymerase I', 'transcription by RNA polymerase II', 'tRNA transcription by RNA polymerase III']
Histone H3
111
Histone H3
111
6.5
82
0.19
A0A6I9KHI6A0A6I9KHI6[][]
Immunoglobulin heavy constant mu
452
Immunoglobulin J chain
91
2.0
59
0.84
P01871P01591['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']['adaptive immune response', 'antibacterial humoral response', 'glomerular filtration', 'humoral immune response', 'immune response', 'innate immune response', 'positive regulation of respiratory burst', 'protein-containing complex assembly', 'retina homeostasis']
Broad substrate specificity ATP-binding cassette transporter ABCG2
438
Broad substrate specificity ATP-binding cassette transporter ABCG2
544
6.6
90
0.17
Q9UNQ0Q9UNQ0['biotin transport', 'cellular detoxification', 'export across plasma membrane', 'lipid transport', 'organic anion transport', 'renal urate salt excretion', 'riboflavin transport', 'transepithelial transport', 'transmembrane transport', 'transport across blood-brain barrier', 'urate metabolic process', 'xenobiotic transport across blood-brain barrier']['biotin transport', 'cellular detoxification', 'export across plasma membrane', 'lipid transport', 'organic anion transport', 'renal urate salt excretion', 'riboflavin transport', 'transepithelial transport', 'transmembrane transport', 'transport across blood-brain barrier', 'urate metabolic process', 'xenobiotic transport across blood-brain barrier']
Calcitonin gene-related peptide 1
84
Calcitonin gene-related peptide type 1 receptor
299
9.8
63
0.16
P06881Q16602['activation of adenylate cyclase activity', 'adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'amylin receptor signaling pathway', 'antibacterial humoral response', 'antifungal humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'calcitonin gene-related peptide receptor signaling pathway', 'cell-cell signaling', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'endothelial cell migration', 'endothelial cell proliferation', 'G protein-coupled receptor internalization', 'innate immune response', 'leukocyte cell-cell adhesion', 'negative regulation of blood pressure', 'negative regulation of bone resorption', 'negative regulation of calcium ion transport into cytosol', 'negative regulation of osteoclast differentiation', 'nervous system process involved in regulation of systemic arterial blood pressure', 'positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway', 'positive regulation of interleukin-1 alpha production', 'positive regulation of interleukin-8 production', 'positive regulation of macrophage differentiation', 'protein phosphorylation', 'receptor internalization', 'regulation of blood pressure', 'regulation of cytosolic calcium ion concentration', 'response to yeast', 'vasculature development', 'vasodilation']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'adrenomedullin receptor signaling pathway', 'angiogenesis', 'calcitonin gene-related peptide receptor signaling pathway', 'calcium ion transport', 'cell surface receptor signaling pathway', 'cellular response to sucrose stimulus', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'heart development', 'negative regulation of inflammatory response', 'negative regulation of smooth muscle contraction', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein transport', 'receptor internalization', 'vascular associated smooth muscle cell proliferation']
COP9 signalosome complex subunit 6
264
COP9 signalosome complex subunit 7b
178
9.7
78
0.13
Q7L5N1Q9H9Q2['protein deneddylation', 'protein neddylation', 'regulation of protein neddylation']['COP9 signalosome assembly', 'protein deneddylation', 'protein neddylation', 'regulation of protein neddylation']
Dynactin subunit 6
148
Dynactin subunit 5
149
8.8
62
0.18
D0G6S1A0A286ZK88['mitotic spindle organization']['aorta development', 'coronary vasculature development', 'ventricular septum development']
39S ribosomal protein L10, mitochondrial
64
39S ribosomal protein S18a, mitochondrial
108
2.9
53
0.64
Q7Z7H8Q9NVS2['mitochondrial translation', 'translation']['mitochondrial translation', 'translation']
DNA-directed RNA polymerase I subunit RPA2
93
DNA-directed RNA polymerases I, II, and III subunit RPABC4
19
9.1
58
0.19
Q9H9Y6P53803['embryo implantation', 'neural crest formation', 'nucleologenesis', 'rRNA transcription']['regulation of transcription by RNA polymerase I', 'transcription by RNA polymerase II', 'transcription by RNA polymerase III']
ATPase GET3
289
ATPase GET3
289
3.5
60
0.48
O43681O43681['post-translational protein targeting to endoplasmic reticulum membrane', 'protein insertion into ER membrane', 'tail-anchored membrane protein insertion into ER membrane']['post-translational protein targeting to endoplasmic reticulum membrane', 'protein insertion into ER membrane', 'tail-anchored membrane protein insertion into ER membrane']
Translation initiation factor eIF-2B subunit beta
194
Translation initiation factor eIF-2B subunit delta
465
9.7
77
0.13
P49770Q9UI10['central nervous system development', 'myelination', 'oligodendrocyte development', 'ovarian follicle development', 'regulation of catalytic activity', 'regulation of translational initiation', 'response to glucose', 'response to heat', 'response to peptide hormone', 'T cell receptor signaling pathway', 'translational initiation']['myelination', 'oligodendrocyte development', 'ovarian follicle development', 'regulation of catalytic activity', 'regulation of translation', 'response to glucose', 'response to heat', 'response to peptide hormone', 'T cell receptor signaling pathway', 'translational initiation']
Glutamate receptor
549
Protein cornichon homolog 2
84
9.9
60
0.17
C9K0Z0O35089[]['localization within membrane', 'negative regulation of anterograde synaptic vesicle transport', 'negative regulation of receptor localization to synapse', 'regulation of AMPA receptor activity', 'regulation of membrane potential', 'regulation of NMDA receptor activity', 'regulation of postsynaptic neurotransmitter receptor activity', 'synaptic transmission, glutamatergic', 'vesicle-mediated transport']
DNA replication licensing factor MCM3
243
DNA replication licensing factor MCM5
219
3.5
71
0.41
P25205P33992['DNA replication initiation', 'DNA strand elongation involved in DNA replication', 'DNA unwinding involved in DNA replication', 'double-strand break repair via break-induced replication', 'mitotic DNA replication initiation', 'regulation of DNA-templated DNA replication initiation']['cell cycle', 'DNA replication', 'DNA replication initiation', 'DNA unwinding involved in DNA replication', 'double-strand break repair via break-induced replication', 'regulation of DNA-templated DNA replication initiation']
39S ribosomal protein L10, mitochondrial
64
39S ribosomal protein S18a, mitochondrial
73
2.9
61
0.56
Q7Z7H8Q9NVS2['mitochondrial translation', 'translation']['mitochondrial translation', 'translation']
Rapamycin-insensitive companion of mTOR
192
Target of rapamycin complex 2 subunit MAPKAP1
27
9.6
80
0.13
Q6R327Q9BPZ7['actin cytoskeleton reorganization', 'cellular response to nutrient levels', 'cytoskeleton organization', 'embryo development ending in birth or egg hatching', 'negative regulation of apoptotic process', 'peptidyl-serine phosphorylation', 'phosphorylation', 'positive regulation of actin filament polymerization', 'positive regulation of cell growth', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of TOR signaling', 'regulation of actin cytoskeleton organization', 'regulation of establishment of cell polarity', 'regulation of gene expression', 'regulation of GTPase activity', 'regulation of inflammatory response', 'regulation of peptidyl-serine phosphorylation', 'regulation of protein kinase B signaling', 'TORC2 signaling']['cellular response to nutrient levels', 'cytoskeleton organization', 'negative regulation of apoptotic process', 'negative regulation of Ras protein signal transduction', 'phosphorylation', 'positive regulation of cell growth', 'positive regulation of peptidyl-serine phosphorylation', 'regulation of cellular response to oxidative stress', 'substantia nigra development', 'TORC2 signaling']
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
130
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
138
9.6
79
0.13
Q9H1K1Q9H1K1['cellular iron ion homeostasis', 'iron-sulfur cluster assembly', 'negative regulation of iron ion import across plasma membrane', 'positive regulation of aconitate hydratase activity', 'positive regulation of mitochondrial electron transport, NADH to ubiquinone']['cellular iron ion homeostasis', 'iron-sulfur cluster assembly', 'negative regulation of iron ion import across plasma membrane', 'positive regulation of aconitate hydratase activity', 'positive regulation of mitochondrial electron transport, NADH to ubiquinone']
Immunoglobulin J chain
123
Immunoglobulin heavy constant mu
452
7.9
64
0.2
P01591P01871['adaptive immune response', 'antibacterial humoral response', 'glomerular filtration', 'humoral immune response', 'immune response', 'innate immune response', 'positive regulation of respiratory burst', 'protein-containing complex assembly', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'defense response to Gram-negative bacterium', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation']
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
134
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
125
9.6
90
0.12
Q9D6J6Q91YT0['aerobic respiration', 'cardiac muscle tissue development', 'mitochondrial electron transport, NADH to ubiquinone', 'nervous system development', 'proton motive force-driven mitochondrial ATP synthesis']['aerobic respiration', 'mitochondrial ATP synthesis coupled electron transport', 'mitochondrial electron transport, NADH to ubiquinone', 'proton motive force-driven mitochondrial ATP synthesis']
Ion channel TACAN
68
Ion channel TACAN
12
7.0
41
0.35
Q8C1E7Q8C1E7['detection of mechanical stimulus involved in sensory perception of pain', 'fat cell differentiation', 'ion transmembrane transport', 'protein heterooligomerization', 'protein homooligomerization']['detection of mechanical stimulus involved in sensory perception of pain', 'fat cell differentiation', 'ion transmembrane transport', 'protein heterooligomerization', 'protein homooligomerization']
Polymeric immunoglobulin receptor
486
Immunoglobulin heavy constant alpha 2
179
2.0
57
0.86
P01833P01877['detection of chemical stimulus involved in sensory perception of bitter taste', 'epidermal growth factor receptor signaling pathway', 'Fc receptor signaling pathway', 'immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor', 'receptor clustering', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']
Dynactin subunit 6
18
Dynactin subunit 5
29
8.2
68
0.18
D0G6S1A0A286ZK88['mitotic spindle organization']['aorta development', 'coronary vasculature development', 'ventricular septum development']
Glutamate receptor
99
Glutamate receptor
99
9.6
62
0.17
G3V9I2G3V9I2[][]
Microtubule-associated protein tau
608
Microtubule-associated protein tau
639
8.2
61
0.2
P10636P10636['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'amyloid fibril formation', 'astrocyte activation', 'axon development', 'axonal transport', 'axonal transport of mitochondrion', 'cell-cell signaling', 'cellular response to brain-derived neurotrophic factor stimulus', 'cellular response to heat', 'cellular response to nerve growth factor stimulus', 'cellular response to reactive oxygen species', 'central nervous system neuron development', 'cytoplasmic microtubule organization', 'generation of neurons', 'internal protein amino acid acetylation', 'intracellular distribution of mitochondria', 'learning or memory', 'memory', 'microglial cell activation', 'microtubule cytoskeleton organization', 'microtubule polymerization', 'negative regulation of establishment of protein localization to mitochondrion', 'negative regulation of gene expression', 'negative regulation of kinase activity', 'negative regulation of mitochondrial fission', 'negative regulation of mitochondrial membrane potential', 'negative regulation of tubulin deacetylation', 'neurofibrillary tangle assembly', 'neuron projection development', 'plus-end-directed organelle transport along microtubule', 'positive regulation of axon extension', 'positive regulation of diacylglycerol kinase activity', 'positive regulation of microtubule polymerization', 'positive regulation of neuron death', 'positive regulation of protein localization', 'positive regulation of protein localization to synapse', 'positive regulation of superoxide anion generation', 'protein homooligomerization', 'protein polymerization', 'regulation of autophagy', 'regulation of calcium-mediated signaling', 'regulation of cellular response to heat', 'regulation of chromosome organization', 'regulation of long-term synaptic depression', 'regulation of microtubule cytoskeleton organization', 'regulation of microtubule polymerization', 'regulation of microtubule polymerization or depolymerization', 'regulation of mitochondrial fission', 'regulation of response to DNA damage stimulus', 'regulation of synaptic plasticity', 'response to lead ion', 'rRNA metabolic process', 'stress granule assembly', 'supramolecular fiber organization', 'synapse assembly', 'synapse organization']['activation of cysteine-type endopeptidase activity involved in apoptotic process', 'amyloid fibril formation', 'astrocyte activation', 'axon development', 'axonal transport', 'axonal transport of mitochondrion', 'cell-cell signaling', 'cellular response to brain-derived neurotrophic factor stimulus', 'cellular response to heat', 'cellular response to nerve growth factor stimulus', 'cellular response to reactive oxygen species', 'central nervous system neuron development', 'cytoplasmic microtubule organization', 'generation of neurons', 'internal protein amino acid acetylation', 'intracellular distribution of mitochondria', 'learning or memory', 'memory', 'microglial cell activation', 'microtubule cytoskeleton organization', 'microtubule polymerization', 'negative regulation of establishment of protein localization to mitochondrion', 'negative regulation of gene expression', 'negative regulation of kinase activity', 'negative regulation of mitochondrial fission', 'negative regulation of mitochondrial membrane potential', 'negative regulation of tubulin deacetylation', 'neurofibrillary tangle assembly', 'neuron projection development', 'plus-end-directed organelle transport along microtubule', 'positive regulation of axon extension', 'positive regulation of diacylglycerol kinase activity', 'positive regulation of microtubule polymerization', 'positive regulation of neuron death', 'positive regulation of protein localization', 'positive regulation of protein localization to synapse', 'positive regulation of superoxide anion generation', 'protein homooligomerization', 'protein polymerization', 'regulation of autophagy', 'regulation of calcium-mediated signaling', 'regulation of cellular response to heat', 'regulation of chromosome organization', 'regulation of long-term synaptic depression', 'regulation of microtubule cytoskeleton organization', 'regulation of microtubule polymerization', 'regulation of microtubule polymerization or depolymerization', 'regulation of mitochondrial fission', 'regulation of response to DNA damage stimulus', 'regulation of synaptic plasticity', 'response to lead ion', 'rRNA metabolic process', 'stress granule assembly', 'supramolecular fiber organization', 'synapse assembly', 'synapse organization']
Pro-adrenomedullin
110
Calcitonin gene-related peptide type 1 receptor
299
8.6
58
0.2
P35318Q16602['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adrenomedullin receptor signaling pathway', 'aging', 'amylin receptor signaling pathway', 'androgen metabolic process', 'animal organ regeneration', 'antibacterial humoral response', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'branching involved in labyrinthine layer morphogenesis', 'calcium ion homeostasis', 'cAMP-mediated signaling', 'cell population proliferation', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'developmental growth', 'female pregnancy', 'G protein-coupled receptor internalization', 'heart development', 'hormone secretion', 'inflammatory response', 'negative regulation of cell population proliferation', 'negative regulation of vascular permeability', 'negative regulation of vasoconstriction', 'neural tube closure', 'neuron projection regeneration', 'odontogenesis of dentin-containing tooth', 'positive regulation of angiogenesis', 'positive regulation of apoptotic process', 'positive regulation of cell population proliferation', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of heart rate', 'positive regulation of progesterone biosynthetic process', 'positive regulation of vasculogenesis', 'receptor internalization', 'regulation of systemic arterial blood pressure', 'regulation of the force of heart contraction', 'regulation of urine volume', 'response to cold', 'response to glucocorticoid', 'response to hypoxia', 'response to insulin', 'response to lipopolysaccharide', 'response to starvation', 'response to wounding', 'signal transduction', 'spongiotrophoblast layer development', 'vascular associated smooth muscle cell development', 'vasculogenesis']['adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'adrenomedullin receptor signaling pathway', 'angiogenesis', 'calcitonin gene-related peptide receptor signaling pathway', 'calcium ion transport', 'cell surface receptor signaling pathway', 'cellular response to sucrose stimulus', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'heart development', 'negative regulation of inflammatory response', 'negative regulation of smooth muscle contraction', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein transport', 'receptor internalization', 'vascular associated smooth muscle cell proliferation']
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
144
NADH-ubiquinone oxidoreductase chain 5
279
2.0
73
0.67
O95169X5BVZ3['aerobic respiration', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'proton motive force-driven mitochondrial ATP synthesis']['ATP synthesis coupled electron transport']
Splicing factor 3B subunit 1
1244
Splicing factor 3B subunit 3
1054
9.6
88
0.12
O75533Q15393['chromatin remodeling', 'mRNA splicing, via spliceosome', 'positive regulation of histone acetylation', 'positive regulation of transcription by RNA polymerase I', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription by RNA polymerase III', 'RNA splicing', 'RNA splicing, via transesterification reactions', 'spliceosomal complex assembly', 'U2-type prespliceosome assembly']['histone H3 acetylation', 'monoubiquitinated histone deubiquitination', 'monoubiquitinated histone H2A deubiquitination', 'mRNA splicing, via spliceosome', 'negative regulation of protein catabolic process', 'positive regulation of transcription, DNA-templated', 'regulation of DNA repair', 'regulation of RNA splicing', 'RNA splicing', 'RNA splicing, via transesterification reactions', 'U2-type prespliceosome assembly']
39S ribosomal protein L10, mitochondrial
64
39S ribosomal protein S18a, mitochondrial
70
1.8
61
0.93
Q7Z7H8Q9NVS2['mitochondrial translation', 'translation']['mitochondrial translation', 'translation']
Glycoprotein hormones alpha chain
31
Choriogonadotropin subunit beta 3
110
9.2
57
0.19
P01215P0DN86['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['apoptotic process', 'cell-cell signaling', 'female gamete generation', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'signal transduction']
Glycoprotein hormones alpha chain
31
Choriogonadotropin subunit beta 3
58
8.1
63
0.2
P01215P0DN86['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['apoptotic process', 'cell-cell signaling', 'female gamete generation', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'signal transduction']
Ribonuclease P/MRP protein subunit POP5
146
Ribonuclease P protein subunit p20
66
7.5
55
0.24
Q969H6O75817['rRNA processing', "tRNA 5'-leader removal", 'tRNA processing']['RNA phosphodiester bond hydrolysis, endonucleolytic', 'rRNA processing', "tRNA 5'-leader removal", 'tRNA processing']
Guided entry of tail-anchored proteins factor 1
157
Guided entry of tail-anchored proteins factor CAMLG
275
3.9
60
0.43
O00258P49069['protein insertion into ER membrane', 'protein stabilization', 'tail-anchored membrane protein insertion into ER membrane']['B cell homeostasis', 'defense response', 'epidermal growth factor receptor signaling pathway', 'negative regulation of proteasomal ubiquitin-dependent protein catabolic process', 'negative regulation of protein ubiquitination', 'protein insertion into ER membrane', 'protein stabilization', 'receptor recycling', 'signal transduction', 'tail-anchored membrane protein insertion into ER membrane', 'vesicle-mediated transport']
Insulin receptor
674
Isoform Short of Insulin receptor
899
9.0
66
0.17
P06213P06213-2['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell'][]
Proteasome subunit alpha type-1
156
26S proteasome regulatory subunit 6A
390
9.5
83
0.13
P18420Q6P6U2['immune system process', 'negative regulation of inflammatory response to antigenic stimulus', 'proteasomal protein catabolic process', 'ubiquitin-dependent protein catabolic process']['protein catabolic process']
Voltage-dependent anion-selective channel protein 2
47
Voltage-dependent anion-selective channel protein 2
103
8.8
36
0.32
F1S2F6F1S2F6[][]
Calcium homeostasis modulator protein 6
198
Calcium homeostasis modulator protein 6
81
7.2
42
0.33
Q5R3K3Q5R3K3[][]
Immunoglobulin heavy constant alpha 1
182
Immunoglobulin heavy constant alpha 1
123
6.5
65
0.24
P01876P01876['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']['adaptive immune response', 'antibacterial humoral response', 'B cell receptor signaling pathway', 'complement activation, classical pathway', 'defense response to bacterium', 'glomerular filtration', 'immune response', 'innate immune response', 'phagocytosis, engulfment', 'phagocytosis, recognition', 'positive regulation of B cell activation', 'positive regulation of respiratory burst', 'retina homeostasis']
DNA-directed RNA polymerase II subunit RPB3
236
DNA-directed RNA polymerases I, II, and III subunit RPABC5
7
9.0
86
0.13
P19387P62875['transcription by RNA polymerase II']['regulation of transcription by RNA polymerase I', 'transcription by RNA polymerase I', 'transcription by RNA polymerase II', 'tRNA transcription by RNA polymerase III']
Replication factor C subunit 3
285
Cell cycle checkpoint protein RAD17
540
5.6
75
0.24
P40938O75943['DNA duplex unwinding', 'DNA repair', 'DNA replication', 'DNA strand elongation involved in DNA replication', 'DNA synthesis involved in DNA repair', 'DNA-templated DNA replication', 'positive regulation of DNA-directed DNA polymerase activity', 'response to organophosphorus']['cellular response to DNA damage stimulus', 'DNA damage checkpoint signaling', 'DNA repair', 'DNA replication checkpoint signaling', 'mitotic DNA replication checkpoint signaling', 'mitotic intra-S DNA damage checkpoint signaling', 'negative regulation of DNA replication', 'regulation of phosphorylation']
Cytochrome b-c1 complex subunit 6, mitochondrial
67
Cytochrome c1, heme protein, mitochondrial
219
9.5
56
0.19
P07919P08574['aerobic respiration', 'cellular respiration', 'mitochondrial electron transport, ubiquinol to cytochrome c', 'oxidative phosphorylation']['cellular respiration', 'mitochondrial electron transport, ubiquinol to cytochrome c', 'response to glucagon']
THO complex subunit 2
500
THO complex subunit 3
261
5.5
82
0.22
Q8NI27Q96J01['blastocyst development', 'cell morphogenesis', 'generation of neurons', 'mRNA export from nucleus', 'mRNA processing', 'negative regulation of neuron projection development', 'neuron development', 'poly(A)+ mRNA export from nucleus', 'regulation of gene expression', 'regulation of mRNA export from nucleus', 'RNA splicing', 'stem cell division', 'viral mRNA export from host cell nucleus']['mRNA export from nucleus', 'mRNA processing', 'RNA splicing', 'viral mRNA export from host cell nucleus']
Sodium channel subunit beta-4
58
Sodium channel protein type 1 subunit alpha
921
9.0
49
0.23
Q8IWT1P35498['AV node cell action potential', 'cardiac muscle cell action potential involved in contraction', 'cardiac muscle contraction', 'establishment of localization in cell', 'membrane depolarization during cardiac muscle cell action potential', 'positive regulation of sodium ion transport', 'regulation of heart rate by cardiac conduction', 'regulation of sodium ion transmembrane transporter activity', 'regulation of ventricular cardiac muscle cell membrane repolarization', 'sodium ion transmembrane transport', 'sodium ion transport']['adult walking behavior', 'cardiac muscle cell action potential involved in contraction', 'detection of mechanical stimulus involved in sensory perception of pain', 'establishment of localization in cell', 'membrane depolarization during action potential', 'neuromuscular process controlling posture', 'neuronal action potential', 'neuronal action potential propagation', 'regulation of ion transmembrane transport', 'sodium ion transmembrane transport', 'sodium ion transport']
Glycoprotein hormones alpha chain
31
Thyrotropin subunit beta
72
8.6
64
0.18
P01215P01222['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['anatomical structure morphogenesis', 'cell-cell signaling', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'response to calcium ion', 'response to estrogen', 'response to vitamin A']
DNA-directed RNA polymerase II subunit RPB3
236
DNA-directed RNA polymerases I, II, and III subunit RPABC5
45
8.1
84
0.15
P19387P62875['transcription by RNA polymerase II']['regulation of transcription by RNA polymerase I', 'transcription by RNA polymerase I', 'transcription by RNA polymerase II', 'tRNA transcription by RNA polymerase III']
DNA-directed RNA polymerase III subunit RPC1
19
DNA-directed RNA polymerase III subunit RPC2
1110
8.5
69
0.17
O14802Q9NW08['defense response to virus', 'innate immune response', 'positive regulation of interferon-beta production', 'transcription, DNA-templated']['defense response to virus', 'innate immune response', 'positive regulation of innate immune response', 'positive regulation of interferon-beta production', 'transcription, DNA-templated']
Hepcidin
66
Solute carrier family 40 member 1
326
8.0
79
0.16
P81172Q9NP59['acute-phase response', 'aging', 'antimicrobial humoral immune response mediated by antimicrobial peptide', 'cellular iron ion homeostasis', 'cellular response to bile acid', 'cellular response to interleukin-6', 'cellular response to lipopolysaccharide', 'cellular response to tumor necrosis factor', 'cellular response to X-ray', 'defense response to bacterium', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'establishment of localization in cell', 'immune response', 'iron ion transmembrane transport', 'killing of cells of another organism', 'liver regeneration', 'macrophage activation', 'multicellular organismal iron ion homeostasis', 'myeloid cell homeostasis', 'negative regulation of bone resorption', 'negative regulation of inflammatory response', 'negative regulation of intestinal absorption', 'negative regulation of ion transmembrane transporter activity', 'negative regulation of iron export across plasma membrane', 'negative regulation of iron ion transmembrane transport', 'negative regulation of iron ion transmembrane transporter activity', 'negative regulation of transcription by RNA polymerase II', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of macrophage activation', 'positive regulation of protein catabolic process', 'positive regulation of protein polyubiquitination', 'positive regulation of receptor catabolic process', 'positive regulation of receptor internalization', 'positive regulation of transcription by RNA polymerase II', 'protein catabolic process', 'receptor signaling pathway via JAK-STAT', 'response to erythropoietin', 'response to ethanol', 'response to iron ion', 'response to iron ion starvation', 'response to vitamin A', 'response to zinc ion', 'transcription by RNA polymerase II']['apoptotic process', 'cellular iron ion homeostasis', 'endothelium development', 'establishment of localization in cell', 'iron ion export across plasma membrane', 'iron ion homeostasis', 'iron ion transmembrane transport', 'lymphocyte homeostasis', 'multicellular organismal iron ion homeostasis', 'negative regulation of apoptotic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of transcription from RNA polymerase II promoter in response to iron', 'spleen trabecula formation', 'transcription by RNA polymerase II']
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
382
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
64
9.7
87
0.12
P25708P15690['mitochondrial electron transport, NADH to ubiquinone']['apoptotic mitochondrial changes', 'ATP metabolic process', 'cellular respiration', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'reactive oxygen species metabolic process', 'regulation of mitochondrial membrane potential']
Actin-related protein 2/3 complex subunit 1B
265
Actin-related protein 2/3 complex subunit 4
21
9.6
86
0.12
O15143P59998['Arp2/3 complex-mediated actin nucleation', 'regulation of actin filament polymerization', 'response to estradiol', 'response to estrogen']['actin filament polymerization', 'actin nucleation', 'Arp2/3 complex-mediated actin nucleation', 'regulation of actin filament polymerization']
Neuronal acetylcholine receptor subunit beta-4
260
Neuronal acetylcholine receptor subunit beta-4
260
7.9
66
0.19
P30926P30926['behavioral response to nicotine', 'chemical synaptic transmission', 'ion transmembrane transport', 'ion transport', 'locomotory behavior', 'membrane depolarization', 'nervous system process', 'neuronal action potential', 'positive regulation of transmission of nerve impulse', 'regulation of membrane potential', 'regulation of neurotransmitter secretion', 'regulation of smooth muscle contraction', 'signal transduction', 'smooth muscle contraction', 'synaptic transmission involved in micturition', 'synaptic transmission, cholinergic']['behavioral response to nicotine', 'chemical synaptic transmission', 'ion transmembrane transport', 'ion transport', 'locomotory behavior', 'membrane depolarization', 'nervous system process', 'neuronal action potential', 'positive regulation of transmission of nerve impulse', 'regulation of membrane potential', 'regulation of neurotransmitter secretion', 'regulation of smooth muscle contraction', 'signal transduction', 'smooth muscle contraction', 'synaptic transmission involved in micturition', 'synaptic transmission, cholinergic']
Endoribonuclease Dicer
284
RISC-loading complex subunit TARBP2
325
9.5
76
0.14
Q9UPY3Q15633['apoptotic DNA fragmentation', 'global gene silencing by mRNA cleavage', 'miRNA metabolic process', 'miRNA processing', 'negative regulation of gene expression', 'negative regulation of Schwann cell proliferation', 'negative regulation of transcription by RNA polymerase II', 'negative regulation of tumor necrosis factor production', 'nerve development', 'neuron projection morphogenesis', 'NIK/NF-kappaB signaling', 'peripheral nervous system myelin formation', 'positive regulation of myelination', 'positive regulation of Schwann cell differentiation', 'pre-miRNA processing', 'RISC complex assembly', 'RNA phosphodiester bond hydrolysis', 'RNA phosphodiester bond hydrolysis, endonucleolytic', 'siRNA processing', 'tRNA catabolic process']['global gene silencing by mRNA cleavage', 'miRNA processing', 'multicellular organism growth', 'negative regulation of defense response to virus by host', 'negative regulation of protein kinase activity', 'neural precursor cell proliferation', 'positive regulation of muscle cell differentiation', 'positive regulation of translation', 'positive regulation of viral genome replication', 'pre-miRNA processing', 'regulation of miRNA maturation', 'regulation of production of small RNA involved in gene silencing by RNA', 'regulation of viral transcription', 'RISC complex assembly', 'single fertilization', 'siRNA processing', 'skeletal muscle tissue regeneration', 'spermatid development']
Glutamate receptor ionotropic, NMDA 1
79
Glutamate receptor ionotropic, NMDA 2A
320
9.5
67
0.16
P35439Q00959['adult locomotory behavior', 'associative learning', 'calcium ion homeostasis', 'calcium ion transmembrane import into cytosol', 'calcium ion transport', 'cation transmembrane transport', 'cation transport', 'cellular calcium ion homeostasis', 'cellular response to manganese ion', 'cerebral cortex development', 'chemical synaptic transmission', 'conditioned taste aversion', 'excitatory postsynaptic potential', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'long-term memory', 'male mating behavior', 'memory', 'negative regulation of neuron apoptotic process', 'neuromuscular process', 'olfactory learning', 'pons maturation', 'positive regulation of apoptotic process', 'positive regulation of calcium ion transport into cytosol', 'positive regulation of cell death', 'positive regulation of cysteine-type endopeptidase activity', 'positive regulation of dendritic spine maintenance', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of reactive oxygen species biosynthetic process', 'positive regulation of Schwann cell migration', 'positive regulation of synaptic transmission, glutamatergic', 'positive regulation of transcription by RNA polymerase II', 'prepulse inhibition', 'propylene metabolic process', 'protein heterotetramerization', 'protein localization to postsynaptic membrane', 'protein-containing complex assembly', 'regulation of axonogenesis', 'regulation of cation transmembrane transport', 'regulation of cell communication', 'regulation of dendrite morphogenesis', 'regulation of long-term neuronal synaptic plasticity', 'regulation of membrane potential', 'regulation of neuron apoptotic process', 'regulation of neuronal synaptic plasticity', 'regulation of respiratory gaseous exchange', 'regulation of synapse assembly', 'regulation of synaptic plasticity', 'response to amine', 'response to amphetamine', 'response to calcium ion', 'response to ethanol', 'response to fungicide', 'response to glycine', 'response to morphine', 'response to organic cyclic compound', 'rhythmic process', 'sensory perception of pain', 'social behavior', 'startle response', 'suckling behavior', 'synaptic transmission, glutamatergic', 'visual learning']['action potential', 'calcium ion transmembrane import into cytosol', 'calcium ion transport', 'cation transmembrane transport', 'cellular response to amino acid stimulus', 'cellular response to dsRNA', 'cellular response to growth factor stimulus', 'cellular response to lipid', 'cellular response to magnesium ion', 'cellular response to manganese ion', 'cellular response to zinc ion', 'cerebral cortex development', 'chemical synaptic transmission', 'dendritic spine organization', 'directional locomotion', 'dopamine metabolic process', 'excitatory postsynaptic potential', 'hippocampus development', 'ionotropic glutamate receptor signaling pathway', 'learning', 'learning or memory', 'locomotion', 'long-term synaptic potentiation', 'memory', 'modulation of chemical synaptic transmission', 'negative regulation of protein catabolic process', 'neurogenesis', 'positive regulation of apoptotic process', 'positive regulation of cell death', 'positive regulation of excitatory postsynaptic potential', 'positive regulation of synaptic transmission, glutamatergic', 'protein localization to postsynaptic membrane', 'regulation of cation transmembrane transport', 'regulation of long-term neuronal synaptic plasticity', 'regulation of membrane potential', 'regulation of neuronal synaptic plasticity', 'regulation of NMDA receptor activity', 'regulation of postsynaptic membrane potential', 'regulation of synaptic plasticity', 'response to amine', 'response to ammonium ion', 'response to amphetamine', 'response to calcium ion', 'response to carbohydrate', 'response to cocaine', 'response to ethanol', 'response to fungicide', 'response to light stimulus', 'response to manganese ion', 'response to methylmercury', 'response to organic cyclic compound', 'response to other organism', 'response to wounding', 'response to xenobiotic stimulus', 'rhythmic process', 'sensory perception of pain', 'serotonin metabolic process', 'sleep', 'spinal cord development', 'startle response', 'visual learning']
Cation-independent mannose-6-phosphate receptor
901
Insulin-like growth factor II
71
9.5
68
0.15
P08169P01344['lysosomal transport']['animal organ morphogenesis', 'embryonic placenta development', 'embryonic placenta morphogenesis', 'exocrine pancreas development', 'glucose metabolic process', 'in utero embryonic development', 'insulin receptor signaling pathway', 'insulin receptor signaling pathway via phosphatidylinositol 3-kinase', 'negative regulation of muscle cell differentiation', 'negative regulation of transcription by RNA polymerase II', 'osteoblast differentiation', 'positive regulation of activated T cell proliferation', 'positive regulation of catalytic activity', 'positive regulation of cell division', 'positive regulation of cell population proliferation', 'positive regulation of glycogen (starch) synthase activity', 'positive regulation of glycogen biosynthetic process', 'positive regulation of insulin receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of multicellular organism growth', 'positive regulation of organ growth', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of skeletal muscle tissue growth', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of vascular endothelial cell proliferation', 'regulation of gene expression by genomic imprinting', 'regulation of histone modification', 'regulation of muscle cell differentiation', 'regulation of transcription, DNA-templated', 'spongiotrophoblast cell proliferation', 'striated muscle cell differentiation']
COP9 signalosome complex subunit 4
378
COP9 signalosome complex subunit 6
266
9.8
70
0.15
Q9BT78Q7L5N1['protein deneddylation', 'protein neddylation', 'regulation of protein neddylation']['protein deneddylation', 'protein neddylation', 'regulation of protein neddylation']
Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)
122
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
9.5
59
0.18
B1H241P63096['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'basement membrane organization', 'cell migration involved in gastrulation', 'cell-cell adhesion involved in gastrulation', 'in utero embryonic development', 'vasculature development', 'visual learning']['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell cycle', 'cell division', 'cellular response to forskolin', 'G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to cell cortex', 'regulation of cAMP-mediated signaling', 'regulation of mitotic spindle organization', 'response to peptide hormone']
Protein tweety homolog 2
101
Protein tweety homolog 2
101
3.5
66
0.44
Q9BSA4Q9BSA4[][]
Large neutral amino acids transporter small subunit 1
164
4F2 cell-surface antigen heavy chain
210
2.0
50
0.99
Q01650P08195['amino acid import across plasma membrane', 'cellular response to glucose starvation', 'cellular response to L-arginine', 'cellular response to lipopolysaccharide', 'isoleucine transport', 'L-leucine import across plasma membrane', 'L-tryptophan transmembrane transport', 'leucine import across plasma membrane', 'liver regeneration', 'negative regulation of autophagy', 'negative regulation of gene expression', 'negative regulation of vascular associated smooth muscle cell apoptotic process', 'neutral amino acid transport', 'odontogenesis', 'phenylalanine transport', 'positive regulation of cytokine production involved in immune response', 'positive regulation of glial cell proliferation', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-17 production', 'positive regulation of interleukin-4 production', 'positive regulation of leucine import across plasma membrane', 'response to hyperoxia', 'response to muscle activity', 'thyroid hormone transport', 'transport across blood-brain barrier', 'valine transport', 'xenobiotic transport']['amino acid transport', 'calcium ion transport', 'carbohydrate metabolic process', 'L-alanine import across plasma membrane', 'L-leucine import across plasma membrane', 'leucine import across plasma membrane', 'leucine transport', 'phenylalanine transport', 'response to exogenous dsRNA', 'tryptophan transport', 'viral entry into host cell']
Insulin-like growth factor-binding protein 3
40
Insulin-like growth factor I
66
9.9
60
0.17
P17936P05019['apoptotic process', 'MAPK cascade', 'negative regulation of cell population proliferation', 'negative regulation of protein phosphorylation', 'negative regulation of signal transduction', 'negative regulation of smooth muscle cell migration', 'negative regulation of smooth muscle cell proliferation', 'osteoblast differentiation', 'positive regulation of apoptotic process', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of myoblast differentiation', 'protein phosphorylation', 'regulation of cell growth', 'regulation of glucose metabolic process', 'regulation of insulin-like growth factor receptor signaling pathway', 'type B pancreatic cell proliferation']['activation of protein kinase B activity', 'bone mineralization involved in bone maturation', 'cell activation', 'cell population proliferation', 'cellular response to amyloid-beta', 'ERK1 and ERK2 cascade', 'glycolate metabolic process', 'insulin-like growth factor receptor signaling pathway', 'muscle hypertrophy', 'muscle organ development', 'myoblast differentiation', 'myoblast proliferation', 'myotube cell development', 'negative regulation of amyloid-beta formation', 'negative regulation of apoptotic process', 'negative regulation of extrinsic apoptotic signaling pathway', 'negative regulation of gene expression', 'negative regulation of interleukin-1 beta production', 'negative regulation of neuroinflammatory response', 'negative regulation of oocyte development', 'negative regulation of release of cytochrome c from mitochondria', 'negative regulation of smooth muscle cell apoptotic process', 'negative regulation of tumor necrosis factor production', 'negative regulation of vascular associated smooth muscle cell apoptotic process', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol-mediated signaling', 'positive regulation of activated T cell proliferation', 'positive regulation of calcineurin-NFAT signaling cascade', 'positive regulation of cardiac muscle hypertrophy', 'positive regulation of cell growth involved in cardiac muscle cell development', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of DNA binding', 'positive regulation of epithelial cell proliferation', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of fibroblast proliferation', 'positive regulation of gene expression', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of glycoprotein biosynthetic process', 'positive regulation of insulin-like growth factor receptor signaling pathway', 'positive regulation of MAPK cascade', 'positive regulation of mitotic nuclear division', 'positive regulation of osteoblast differentiation', 'positive regulation of peptidyl-tyrosine phosphorylation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein secretion', 'positive regulation of Ras protein signal transduction', 'positive regulation of smooth muscle cell migration', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription regulatory region DNA binding', 'positive regulation of transcription, DNA-templated', 'positive regulation of trophectodermal cell proliferation', 'positive regulation of tyrosine phosphorylation of STAT protein', 'positive regulation of vascular associated smooth muscle cell proliferation', 'protein kinase B signaling', 'protein stabilization', 'proteoglycan biosynthetic process', 'Ras protein signal transduction', 'regulation of gene expression', 'regulation of multicellular organism growth', 'regulation of protein phosphorylation', 'response to heat', 'signal transduction', 'skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration', 'skeletal system development', 'wound healing']
Acylglycerol kinase, mitochondrial
43
Mitochondrial import inner membrane translocase subunit Tim29
149
4.3
69
0.33
Q53H12Q9BSF4['ceramide biosynthetic process', 'glycerolipid metabolic process', 'phosphorylation', 'protein insertion into mitochondrial inner membrane', 'sphingolipid metabolic process']['protein insertion into mitochondrial inner membrane']
DNA-directed RNA polymerase III subunit RPC1
1126
DNA-directed RNA polymerase III subunit RPC10
20
9.9
50
0.2
O14802Q9Y2Y1['defense response to virus', 'innate immune response', 'positive regulation of interferon-beta production', 'transcription, DNA-templated']['defense response to virus', 'innate immune response', 'termination of RNA polymerase III transcription', 'transcription by RNA polymerase III', "tRNA 3'-trailer cleavage"]
Broad substrate specificity ATP-binding cassette transporter ABCG2
544
Broad substrate specificity ATP-binding cassette transporter ABCG2
544
4.4
80
0.28
Q9UNQ0Q9UNQ0['biotin transport', 'cellular detoxification', 'export across plasma membrane', 'lipid transport', 'organic anion transport', 'renal urate salt excretion', 'riboflavin transport', 'transepithelial transport', 'transmembrane transport', 'transport across blood-brain barrier', 'urate metabolic process', 'xenobiotic transport across blood-brain barrier']['biotin transport', 'cellular detoxification', 'export across plasma membrane', 'lipid transport', 'organic anion transport', 'renal urate salt excretion', 'riboflavin transport', 'transepithelial transport', 'transmembrane transport', 'transport across blood-brain barrier', 'urate metabolic process', 'xenobiotic transport across blood-brain barrier']
Insulin receptor
551
Insulin receptor
709
9.5
47
0.22
P06213P06213['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell']['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell']
Glycoprotein hormones alpha chain
111
Thyrotropin subunit beta
72
9.9
81
0.12
P01215P01222['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['anatomical structure morphogenesis', 'cell-cell signaling', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'response to calcium ion', 'response to estrogen', 'response to vitamin A']
C-C chemokine receptor type 2
32
C-C motif chemokine 2
34
8.7
64
0.18
P41597P13500['blood vessel remodeling', 'calcium-mediated signaling', 'cell chemotaxis', 'cellular calcium ion homeostasis', 'cellular defense response', 'cellular homeostasis', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'dendritic cell chemotaxis', 'immune response', 'inflammatory response', 'inflammatory response to wounding', 'macrophage migration', 'monocyte extravasation', 'negative regulation of adenylate cyclase activity', 'negative regulation of angiogenesis', 'negative regulation of eosinophil degranulation', 'negative regulation of type 2 immune response', 'positive regulation of alpha-beta T cell proliferation', 'positive regulation of astrocyte chemotaxis', 'positive regulation of CD8-positive, alpha-beta T cell extravasation', 'positive regulation of cold-induced thermogenesis', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of hematopoietic stem cell migration', 'positive regulation of immune complex clearance by monocytes and macrophages', 'positive regulation of inflammatory response', 'positive regulation of interferon-gamma production', 'positive regulation of interleukin-2 production', 'positive regulation of monocyte chemotaxis', 'positive regulation of monocyte extravasation', 'positive regulation of NMDA glutamate receptor activity', 'positive regulation of synaptic transmission, glutamatergic', 'positive regulation of T cell activation', 'positive regulation of T cell chemotaxis', 'positive regulation of T-helper 1 type immune response', 'positive regulation of thymocyte migration', 'positive regulation of tumor necrosis factor production', 'receptor signaling pathway via JAK-STAT', 'regulation of inflammatory response', 'regulation of T cell cytokine production', 'regulation of T cell differentiation', 'regulation of vascular endothelial growth factor production', 'response to wounding', 'sensory perception of pain', 'T-helper 17 cell chemotaxis']['angiogenesis', 'animal organ morphogenesis', 'astrocyte cell migration', 'cell adhesion', 'cell surface receptor signaling pathway', 'cellular homeostasis', 'cellular response to fibroblast growth factor stimulus', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to lipopolysaccharide', 'cellular response to organic cyclic compound', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'cytokine-mediated signaling pathway', 'cytoskeleton organization', 'eosinophil chemotaxis', 'G protein-coupled receptor signaling pathway', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'helper T cell extravasation', 'humoral immune response', 'inflammatory response', 'lipopolysaccharide-mediated signaling pathway', 'lymphocyte chemotaxis', 'macrophage chemotaxis', 'MAPK cascade', 'monocyte chemotaxis', 'negative regulation of G1/S transition of mitotic cell cycle', 'negative regulation of glial cell apoptotic process', 'negative regulation of natural killer cell chemotaxis', 'negative regulation of neuron apoptotic process', 'negative regulation of vascular endothelial cell proliferation', 'neutrophil chemotaxis', 'positive regulation of apoptotic cell clearance', 'positive regulation of calcium ion import', 'positive regulation of endothelial cell apoptotic process', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of nitric-oxide synthase biosynthetic process', 'positive regulation of NMDA glutamate receptor activity', 'positive regulation of synaptic transmission, glutamatergic', 'positive regulation of T cell activation', 'protein kinase B signaling', 'protein phosphorylation', 'receptor signaling pathway via JAK-STAT', 'regulation of cell shape', 'response to bacterium', 'sensory perception of pain', 'signal transduction', 'viral genome replication']
Igh protein
318
Polymeric immunoglobulin receptor
488
1.5
64
1.03
Q99M22O70570[]['detection of chemical stimulus involved in sensory perception of bitter taste', 'epidermal growth factor receptor signaling pathway', 'Fc receptor signaling pathway', 'immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor', 'receptor clustering']
Protein inturned
838
Protein fuzzy homolog
365
7.5
83
0.16
Q059U7E9QL29['cell division', 'cilium assembly', 'embryonic digit morphogenesis', 'establishment of planar polarity', 'hair follicle morphogenesis', 'intraciliary transport', 'keratinocyte differentiation', 'limb development', 'motile cilium assembly', 'negative regulation of cell division', 'negative regulation of keratinocyte proliferation', 'nervous system development', 'neural tube development', 'non-motile cilium assembly', 'positive regulation of smoothened signaling pathway', 'protein localization to organelle', 'regulation of cilium assembly', 'regulation of ossification', 'regulation of smoothened signaling pathway', 'roof of mouth development', 'smoothened signaling pathway', 'spinal cord dorsal/ventral patterning', 'tongue morphogenesis', 'vesicle-mediated transport']['negative regulation of cell migration', 'neural tube closure', 'non-motile cilium assembly', 'positive regulation of cilium assembly', 'vesicle-mediated transport']
Voltage-dependent anion-selective channel protein 2
47
Voltage-dependent anion-selective channel protein 2
47
1.2
34
2.43
F1S2F6F1S2F6[][]
C-C motif chemokine 20
32
C-C chemokine receptor type 6
36
8.8
66
0.17
P78556P51684['antimicrobial humoral immune response mediated by antimicrobial peptide', 'calcium-mediated signaling using intracellular calcium source', 'cell chemotaxis', 'cell-cell signaling', 'cellular response to interferon-gamma', 'cellular response to interleukin-1', 'cellular response to tumor necrosis factor', 'chemokine-mediated signaling pathway', 'chemotaxis', 'defense response to bacterium', 'G protein-coupled receptor signaling pathway', 'immune response', 'inflammatory response', 'killing of cells of another organism', 'lymphocyte chemotaxis', 'monocyte chemotaxis', 'neutrophil chemotaxis', 'positive regulation of ERK1 and ERK2 cascade', 'positive regulation of GTPase activity', 'positive regulation of T cell migration', 'signal transduction', 'T cell migration', 'thymocyte migration']['calcium-mediated signaling', 'cell chemotaxis', 'cellular defense response', 'chemotaxis', 'dendritic cell chemotaxis', 'DN2 thymocyte differentiation', 'DN3 thymocyte differentiation', 'humoral immune response', 'immune response', 'isotype switching to IgA isotypes', 'leukocyte migration involved in inflammatory response', 'lymphocyte migration', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of dendritic cell chemotaxis', 'positive regulation of flagellated sperm motility involved in capacitation', 'regulation of T cell migration', 'signal transduction', 'T cell migration', 'thymocyte migration']
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
149
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
141
2.0
79
0.62
O96000Q9NX14['aerobic respiration', 'mitochondrial electron transport, NADH to ubiquinone', 'mitochondrial respiratory chain complex I assembly', 'proton motive force-driven mitochondrial ATP synthesis']['aerobic respiration', 'mitochondrial respiratory chain complex I assembly', 'proton motive force-driven mitochondrial ATP synthesis']
Protein tweety homolog 2
101
Protein tweety homolog 2
100
9.6
73
0.14
Q9BSA4Q9BSA4[][]
General transcription and DNA repair factor IIH helicase subunit XPD
588
General transcription factor IIH subunit 2
177
8.5
62
0.19
P18074Q13888['aging', 'apoptotic process', 'bone mineralization', 'central nervous system myelin formation', 'chromosome segregation', 'embryonic cleavage', 'erythrocyte maturation', 'extracellular matrix organization', 'hair cell differentiation', 'hair follicle maturation', 'hematopoietic stem cell differentiation', 'hematopoietic stem cell proliferation', 'in utero embryonic development', 'maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)', 'multicellular organism growth', 'nucleotide-excision repair', 'nucleotide-excision repair, DNA duplex unwinding', 'nucleotide-excision repair, DNA incision', 'positive regulation of DNA binding', 'positive regulation of mitotic recombination', 'post-embryonic development', 'regulation of mitotic cell cycle phase transition', 'response to oxidative stress', 'spinal cord development', 'transcription by RNA polymerase II', 'transcription elongation from RNA polymerase I promoter', 'transcription-coupled nucleotide-excision repair', 'UV protection']['G protein-coupled receptor internalization', 'nucleotide-excision repair', 'positive regulation of DNA helicase activity', 'regulation of transcription by RNA polymerase II', 'response to UV', 'transcription by RNA polymerase II', 'transcription initiation from RNA polymerase II promoter']
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
Muscarinic acetylcholine receptor M4
456
8.5
62
0.19
P63096P08173['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell cycle', 'cell division', 'cellular response to forskolin', 'G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to cell cortex', 'regulation of cAMP-mediated signaling', 'regulation of mitotic spindle organization', 'response to peptide hormone']['adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway', 'cell surface receptor signaling pathway', 'chemical synaptic transmission', 'G protein-coupled acetylcholine receptor signaling pathway', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'regulation of locomotion', 'signal transduction']
Insulin-like growth factor 1 receptor
544
Insulin receptor
551
2.0
56
0.88
P08069P06213['aging', 'amyloid-beta clearance', 'axonogenesis', 'cardiac atrium development', 'cellular response to aldosterone', 'cellular response to amyloid-beta', 'cellular response to angiotensin', 'cellular response to dexamethasone stimulus', 'cellular response to estradiol stimulus', 'cellular response to glucose stimulus', 'cellular response to insulin-like growth factor stimulus', 'cellular response to mechanical stimulus', 'cellular response to progesterone stimulus', 'cellular response to testosterone stimulus', 'cellular response to transforming growth factor beta stimulus', 'cellular senescence', 'cerebellum development', 'dendritic spine maintenance', 'establishment of cell polarity', 'estrous cycle', 'glucose homeostasis', 'hippocampus development', 'immune response', 'insulin receptor signaling pathway', 'insulin-like growth factor receptor signaling pathway', 'negative regulation of apoptotic process', 'negative regulation of cholangiocyte apoptotic process', 'negative regulation of hepatocyte apoptotic process', 'negative regulation of MAPK cascade', 'negative regulation of muscle cell apoptotic process', 'peptidyl-tyrosine autophosphorylation', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol-mediated signaling', 'positive regulation of axon regeneration', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of cold-induced thermogenesis', 'positive regulation of cytokinesis', 'positive regulation of DNA metabolic process', 'positive regulation of kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of osteoblast proliferation', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein-containing complex disassembly', 'positive regulation of smooth muscle cell proliferation', 'positive regulation of steroid hormone biosynthetic process', 'protein autophosphorylation', 'regulation of JNK cascade', 'response to ethanol', 'response to L-glutamate', 'response to nicotine', 'response to vitamin E', 'signal transduction', 'transcytosis', 'transmembrane receptor protein tyrosine kinase signaling pathway']['activation of protein kinase activity', 'activation of protein kinase B activity', 'adrenal gland development', 'amyloid-beta clearance', 'carbohydrate metabolic process', 'cellular response to growth factor stimulus', 'cellular response to insulin stimulus', 'dendritic spine maintenance', 'epidermis development', 'exocrine pancreas development', 'G protein-coupled receptor signaling pathway', 'glucose homeostasis', 'heart morphogenesis', 'insulin receptor signaling pathway', 'learning', 'male gonad development', 'male sex determination', 'memory', 'neuron projection maintenance', 'peptidyl-tyrosine autophosphorylation', 'peptidyl-tyrosine phosphorylation', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of developmental growth', 'positive regulation of glucose import', 'positive regulation of glycogen biosynthetic process', 'positive regulation of glycolytic process', 'positive regulation of kinase activity', 'positive regulation of MAP kinase activity', 'positive regulation of MAPK cascade', 'positive regulation of meiotic cell cycle', 'positive regulation of mitotic nuclear division', 'positive regulation of nitric oxide biosynthetic process', 'positive regulation of phosphatidylinositol 3-kinase signaling', 'positive regulation of protein kinase B signaling', 'positive regulation of protein phosphorylation', 'positive regulation of protein-containing complex disassembly', 'positive regulation of receptor internalization', 'positive regulation of respiratory burst', 'positive regulation of transcription, DNA-templated', 'protein autophosphorylation', 'protein phosphorylation', 'receptor-mediated endocytosis', 'regulation of embryonic development', 'regulation of female gonad development', 'regulation of transcription, DNA-templated', 'transmembrane receptor protein tyrosine kinase signaling pathway', 'transport across blood-brain barrier', 'viral entry into host cell']
F-box/LRR-repeat protein 5
226
S-phase kinase-associated protein 1
160
4.8
nan
nan
Q9UKA1P63208['iron ion homeostasis', 'positive regulation of protein catabolic process', 'protein ubiquitination', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process']['histone H2A monoubiquitination', 'maintenance of protein location in nucleus', 'positive regulation of ubiquitin protein ligase activity', 'protein K48-linked ubiquitination', 'protein polyubiquitination', 'protein ubiquitination', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process']
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
524
Phosphoinositide 3-kinase regulatory subunit 5
120
3.4
57
0.51
P48736O02696['adaptive immune response', 'angiogenesis', 'cell migration', 'cellular response to cAMP', 'dendritic cell chemotaxis', 'endocytosis', 'G protein-coupled receptor signaling pathway', 'hepatocyte apoptotic process', 'immune response', 'inflammatory response', 'innate immune response', 'mast cell degranulation', 'natural killer cell chemotaxis', 'negative regulation of cardiac muscle contraction', 'negative regulation of fibroblast apoptotic process', 'negative regulation of triglyceride catabolic process', 'neutrophil chemotaxis', 'neutrophil extravasation', 'phosphatidylinositol 3-kinase signaling', 'phosphatidylinositol phosphate biosynthetic process', 'phosphatidylinositol-3-phosphate biosynthetic process', 'phosphatidylinositol-mediated signaling', 'phosphorylation', 'platelet aggregation', 'positive regulation of acute inflammatory response', 'positive regulation of cytokine production', 'positive regulation of cytosolic calcium ion concentration', 'positive regulation of endothelial cell migration', 'positive regulation of MAP kinase activity', 'positive regulation of protein kinase B signaling', 'positive regulation of Rac protein signal transduction', 'protein phosphorylation', 'regulation of calcium ion transmembrane transport', 'regulation of cell adhesion mediated by integrin', 'respiratory burst involved in defense response', 'secretory granule localization', 'sphingosine-1-phosphate receptor signaling pathway', 'T cell activation', 'T cell chemotaxis', 'T cell proliferation']['G protein-coupled receptor signaling pathway', 'phosphatidylinositol 3-kinase signaling', 'positive regulation of MAP kinase activity', 'positive regulation of protein kinase B signaling']
DNA-directed RNA polymerase subunit
1430
DNA-directed RNA polymerase subunit beta
1232
9.5
71
0.15
A0A480TA59A0A4X1TVZ5['transcription by RNA polymerase II']['transcription, DNA-templated']
Lutropin-choriogonadotropic hormone receptor
156
Choriogonadotropin subunit beta 3
120
8.2
83
0.15
P22888P0DN86['activation of adenylate cyclase activity', 'adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'arachidonic acid secretion', 'cellular response to gonadotropin stimulus', 'cellular response to luteinizing hormone stimulus', 'central nervous system development', 'cognition', 'development of secondary male sexual characteristics', 'G protein-coupled receptor signaling pathway', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'hormone-mediated signaling pathway', 'luteinizing hormone signaling pathway', 'male genitalia development', 'male gonad development', 'ovarian follicle development', 'ovulation cycle process', 'phospholipase C-activating G protein-coupled receptor signaling pathway', 'positive regulation of calcium ion transport into cytosol', 'positive regulation of calcium-mediated signaling', 'positive regulation of hormone biosynthetic process', 'positive regulation of inositol trisphosphate biosynthetic process', 'positive regulation of release of sequestered calcium ion into cytosol', 'protein targeting to lysosome', 'regulation of steroid hormone biosynthetic process', 'response to xenobiotic stimulus', 'seminiferous tubule development', 'spermatogenesis', 'uterus development']['apoptotic process', 'cell-cell signaling', 'female gamete generation', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'signal transduction']
Mediator of RNA polymerase II transcription subunit 17
649
Mediator of RNA polymerase II transcription subunit 28
93
7.9
62
0.2
Q9NVC6Q9H204['positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription elongation from RNA polymerase II promoter', 'positive regulation of transcription initiation from RNA polymerase II promoter', 'positive regulation of transcription, DNA-templated', 'regulation of transcription by RNA polymerase II', 'RNA polymerase II preinitiation complex assembly', 'somatic stem cell population maintenance', 'transcription initiation from RNA polymerase II promoter']['negative regulation of smooth muscle cell differentiation', 'positive regulation of transcription elongation from RNA polymerase II promoter', 'positive regulation of transcription initiation from RNA polymerase II promoter', 'RNA polymerase II preinitiation complex assembly', 'somatic stem cell population maintenance']
Mediator of RNA polymerase II transcription subunit 1
464
Mediator of RNA polymerase II transcription subunit 24
93
10.0
70
0.14
Q15648O75448['androgen biosynthetic process', 'angiogenesis', 'animal organ regeneration', 'brain development', 'cell morphogenesis', 'cellular response to epidermal growth factor stimulus', 'cellular response to hepatocyte growth factor stimulus', 'cellular response to steroid hormone stimulus', 'cellular response to thyroid hormone stimulus', 'embryonic heart tube development', 'embryonic hemopoiesis', 'embryonic hindlimb morphogenesis', 'embryonic placenta development', 'enucleate erythrocyte development', 'epithelial cell proliferation involved in mammary gland duct elongation', 'erythrocyte development', 'fat cell differentiation', 'G0 to G1 transition', 'hematopoietic stem cell differentiation', 'intracellular steroid hormone receptor signaling pathway', 'keratinocyte differentiation', 'lactation', 'lens development in camera-type eye', 'liver development', 'mammary gland branching involved in pregnancy', 'mammary gland branching involved in thelarche', 'megakaryocyte development', 'monocyte differentiation', 'mRNA transcription by RNA polymerase II', 'negative regulation of apoptotic process', 'negative regulation of keratinocyte proliferation', 'negative regulation of neuron differentiation', 'negative regulation of transcription by RNA polymerase II', 'peroxisome proliferator activated receptor signaling pathway', 'positive regulation of erythrocyte differentiation', 'positive regulation of G0 to G1 transition', 'positive regulation of gene expression', 'positive regulation of hepatocyte proliferation', 'positive regulation of interferon-gamma-mediated signaling pathway', 'positive regulation of intracellular estrogen receptor signaling pathway', 'positive regulation of keratinocyte differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of transcription elongation from RNA polymerase II promoter', 'positive regulation of transcription initiation from RNA polymerase II promoter', 'positive regulation of transcription, DNA-templated', 'protein import into nucleus', 'regulation of RNA biosynthetic process', 'regulation of transcription by RNA polymerase II', 'regulation of vitamin D receptor signaling pathway', 'retinal pigment epithelium development', 'RNA polymerase II preinitiation complex assembly', 'thyroid hormone generation', 'thyroid hormone mediated signaling pathway', 'ventricular trabecula myocardium morphogenesis']['positive regulation of transcription elongation from RNA polymerase II promoter', 'positive regulation of transcription initiation from RNA polymerase II promoter', 'positive regulation of transcription, DNA-templated', 'RNA polymerase II preinitiation complex assembly']
F-box/WD repeat-containing protein 8
139
S-phase kinase-associated protein 1
160
9.4
nan
nan
Q8N3Y1P63208['cell population proliferation', 'Golgi organization', 'labyrinthine layer blood vessel development', 'positive regulation of dendrite morphogenesis', 'positive regulation of transcription factor catabolic process', 'protein ubiquitination', 'spongiotrophoblast layer development']['histone H2A monoubiquitination', 'maintenance of protein location in nucleus', 'positive regulation of ubiquitin protein ligase activity', 'protein K48-linked ubiquitination', 'protein polyubiquitination', 'protein ubiquitination', 'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process']
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
241
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
72
6.1
86
0.19
P46977P61803['co-translational protein modification', 'post-translational protein modification', 'protein N-linked glycosylation', 'protein N-linked glycosylation via asparagine']['apoptotic process', 'blastocyst development', 'negative regulation of apoptotic process', 'protein glycosylation', 'protein N-linked glycosylation', 'protein N-linked glycosylation via asparagine', 'regulation of protein stability', 'response to nutrient', 'response to xenobiotic stimulus']
Glutamate receptor ionotropic, delta-1
96
Glutamate receptor ionotropic, delta-1
96
9.5
77
0.14
Q62640Q62640['modulation of chemical synaptic transmission', 'social behavior', 'synaptic transmission, glutamatergic']['modulation of chemical synaptic transmission', 'social behavior', 'synaptic transmission, glutamatergic']
Glycoprotein hormones alpha chain
55
Choriogonadotropin subunit beta 3
29
9.0
75
0.15
P01215P0DN86['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['apoptotic process', 'cell-cell signaling', 'female gamete generation', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'signal transduction']
DNA-directed RNA polymerase III subunit RPC2
919
DNA-directed RNA polymerases I, II, and III subunit RPABC5
10
7.9
95
0.13
Q9NW08P62875['defense response to virus', 'innate immune response', 'positive regulation of innate immune response', 'positive regulation of interferon-beta production', 'transcription, DNA-templated']['regulation of transcription by RNA polymerase I', 'transcription by RNA polymerase I', 'transcription by RNA polymerase II', 'tRNA transcription by RNA polymerase III']
COP9 signalosome complex subunit 6
264
COP9 signalosome complex subunit 7b
181
9.5
55
0.19
Q7L5N1Q9H9Q2['protein deneddylation', 'protein neddylation', 'regulation of protein neddylation']['COP9 signalosome assembly', 'protein deneddylation', 'protein neddylation', 'regulation of protein neddylation']
Cytochrome c
18
Cytochrome c1, heme protein, mitochondrial
124
9.6
69
0.15
P62894P00125['apoptotic process', 'mitochondrial electron transport, cytochrome c to oxygen', 'mitochondrial electron transport, ubiquinol to cytochrome c', 'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process']['mitochondrial electron transport, ubiquinol to cytochrome c']
Transmembrane protein 120B
169
Transmembrane protein 120B
169
7.9
66
0.19
A0PK00A0PK00['fat cell differentiation', 'protein heterooligomerization']['fat cell differentiation', 'protein heterooligomerization']
26S proteasome non-ATPase regulatory subunit 2
236
26S proteasome regulatory subunit 4
58
6.6
62
0.25
Q4FZT9P62193['proteasome-mediated ubiquitin-dependent protein catabolic process', 'regulation of protein catabolic process']['negative regulation of neuron death', 'proteasome-mediated ubiquitin-dependent protein catabolic process']
Glycoprotein hormones alpha chain
31
Choriogonadotropin subunit beta 3
29
9.9
60
0.17
P01215P0DN86['follicle-stimulating hormone secretion', 'follicle-stimulating hormone signaling pathway', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'luteinizing hormone secretion', 'negative regulation of organ growth', 'organ growth', 'positive regulation of cell migration', 'positive regulation of cell population proliferation', 'positive regulation of steroid biosynthetic process', 'positive regulation of transcription by RNA polymerase II', 'regulation of signaling receptor activity', 'thyroid gland development', 'thyroid hormone generation']['apoptotic process', 'cell-cell signaling', 'female gamete generation', 'G protein-coupled receptor signaling pathway', 'hormone-mediated signaling pathway', 'signal transduction']
Guanine nucleotide-binding protein G(i) subunit alpha-1
351
5-hydroxytryptamine receptor 4
123
9.9
71
0.14
P63096Q13639['adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway', 'adenylate cyclase-modulating G protein-coupled receptor signaling pathway', 'cell cycle', 'cell division', 'cellular response to forskolin', 'G protein-coupled receptor signaling pathway', 'positive regulation of protein localization to cell cortex', 'regulation of cAMP-mediated signaling', 'regulation of mitotic spindle organization', 'response to peptide hormone']['adenylate cyclase-inhibiting serotonin receptor signaling pathway', 'chemical synaptic transmission', 'G protein-coupled receptor signaling pathway', 'G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger', 'regulation of appetite']
Interleukin-17A
99
Interleukin-17A
99
9.7
78
0.13
Q16552Q16552['adaptive immune response', 'apoptotic process', 'cell death', 'cell-cell signaling', 'cellular response to interleukin-1', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'fibroblast activation', 'granulocyte migration', 'immune response', 'inflammatory response', 'innate immune response', 'interleukin-17-mediated signaling pathway', 'intestinal epithelial structure maintenance', 'Notch signaling pathway', 'positive regulation of antimicrobial peptide production', 'positive regulation of bicellular tight junction assembly', 'positive regulation of chemokine (C-X-C motif) ligand 1 production', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-16 production', 'positive regulation of interleukin-23 production', 'positive regulation of interleukin-6 production', 'positive regulation of osteoclast differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production']['adaptive immune response', 'apoptotic process', 'cell death', 'cell-cell signaling', 'cellular response to interleukin-1', 'defense response to fungus', 'defense response to Gram-negative bacterium', 'defense response to Gram-positive bacterium', 'fibroblast activation', 'granulocyte migration', 'immune response', 'inflammatory response', 'innate immune response', 'interleukin-17-mediated signaling pathway', 'intestinal epithelial structure maintenance', 'Notch signaling pathway', 'positive regulation of antimicrobial peptide production', 'positive regulation of bicellular tight junction assembly', 'positive regulation of chemokine (C-X-C motif) ligand 1 production', 'positive regulation of cytokine production involved in inflammatory response', 'positive regulation of interleukin-1 beta production', 'positive regulation of interleukin-12 production', 'positive regulation of interleukin-16 production', 'positive regulation of interleukin-23 production', 'positive regulation of interleukin-6 production', 'positive regulation of osteoclast differentiation', 'positive regulation of transcription by RNA polymerase II', 'positive regulation of tumor necrosis factor production']
Last updated: 2022-10-10
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